@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2544_HUMAN: (2015-12-09 )
MEDKRNIQIIEWEHLDKKKFYVFGVAMTMMIRVSVYPFTLIRTRLQVQKGKSLYHGTFDAFIKILRADGITGLYRGFLVNTFTLISGQCYVTTYELTRKFVADYSQSNTVKSLVAGGSASLVAQSITVPIDVVSQHLMMQRKGEKMGRFQVRGNPEGQGVVAFGQTKDIIRQILQADGLRGFYRGYVASLLTYIPNSAVWWPFYHFYAEQLSYLCPKECPHIVFQAVSGPLAAATASILTNPMDVIRTRVQVEGKNSIILTFRQLMAEEGPWGLMKGLSARIISATPSTIVIVVGYESLKKLSLRPELVDSRHW
Atome Classification :
(20 SA)
---------------------------------------------------------------------------.........10--.--.......---.20........30..-----......40....------...--------.------50---------...---..-...60......-----------..70....---------....80.....-..-.---90.-------------------------.....---..---100------..--.------.-------------.----..-----110--......-----------------------..120......---.130----...----------------.....140........150.......160------------------------------.......170----.----...-...180..-------------.....190---...--------.....200.......----210------.......220....--..----------.230--.........240.-...-....250---....--.--------.---..-----.260----.........270.......280.......290-........300.......310..------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------MEDKR
N
I
Q
I
I
---
E
--
W
EHLDKK---
K
F
Y
V
F
G
V
A
M
T
M
M
I
R
V
-----SVY
P
F
T
L
I
R
T
R
L
------
Q
V
Q--------K------GK---------SLY---HG-
T
F
D
A
F
I
K
I
L
RA-----------DG
I
T
G
L
Y
R
---------
G
F
L
V
N
T
F
T
L
IS-
G
Q
-
C
---
Y
V
T
-------------------------
T
Y
E
L
T
---
R
K
---
F
V
A
------DY--S------Q-------------S----
N
T
-----
V
K
---
S
L
VAGG-----------------------
S
A
S
L
V
A
QSITV---
P
I
D
-----
V
V
S
----------------
Q
H
L
M
M
Q
-
R
KGEKM
G
R
F
Q
V
RGNPEG
Q
G
V
V
A
------------------------------FG
Q
T
K
D
I
I
R
Q
----
I
----
L
Q
A-DG
L
R
G
F
Y
R
-------------
G
Y
V
A
S
L
L
----
T
YI--------PNSA
V
W
W
P
F
Y
H
F
Y
A
E
----
Q
L
S
------
Y
LC
P
K
E
C
P
H
I
V
F
Q
A--VS----------G
P
----
L
A
A
A
T
A
S
I
LT-N
P
-
M
D
V
-
I
R
T
R
V
-----
Q
VEG--K--------
N
---
S
I
-----
I
L
------
T
F
R
Q
L
M
AEEG
P
W
G
L
M
K
G
LS
A
R
I
ISATP
S
T
I
V
--
I
V
V
G
Y
E
S
L
K
K
LSLR
P
E
LVDSRHW------------------------------------
1
PsiBlast_PDB
89.19
23%
-82
- C6 -
1OKC
10
ADT1_BOVIN
A:
[9-293]
-------------------------------------------------------------------------------------------------
K
---
D
F
L
A
G
G
V
A
A
A
I
S
-
K
T
-----
A
V
A
P
I
E
R
V
K
L
L
L
------
Q
V
Q
HASKQI--
S
------
A
E
---------
K
Q
Y
---
K
G
-
I
I
D
C
V
V
R
I
P
K
E
-----------
Q
G
F
L
S
F
W
R
---------
G
N
L
A
N
V
I
R
-----------
Y
F
P
-------------------------
T
Q
A
L
N
---
F
A
---
F
K
D
------
K
Y
--
K
------
Q
I
F
L
GGVDRHKQ
F
W
R
----
Y
F
-----
A
G
---
N
L
A
S
G
G
-----------------------
A
A
G
A
T
S
L
C
F
V
Y
---
P
L
D
-----
F
A
R
----------------
T
R
L
A
A
D
V
G
K
G
A
A
Q
R
E
F
T
G
L
G
N
--------------------------------------------
C
I
T
K
----
I
----
F
K
S
-
D
G
L
R
G
L
Y
Q
-------------
G
F
N
V
S
V
Q
----
G
I
I
--------
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
----
M
L
P
--------
D
P
K
N
V
-
H
I
I
V
S
W
--
M
I
----------
A
Q
----
T
V
T
A
V
A
G
L
V
S
-
Y
P
-
F
D
T
-
V
R
R
R
M
-----
M
M
Q
S
GR
K
--------
G
---
A
D
-----
I
M
YTG
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
--
L
V
L
-
Y
D
E
I
---------------------------------------------------
2
PsiBlast_PDB
88.80
23%
-83
- C6 -
2C3E
4
ADT1_BOVIN
A:
[9-293]
-------------------------------------------------------------------------------------------------
K
---
D
F
L
A
G
G
V
A
A
A
I
S
-
K
T
-----
A
V
A
P
I
E
R
V
K
L
L
L
------
Q
V
Q
HASKQI--
S
------
A
E
---------
K
Q
Y
---
K
G
-
I
I
D
C
V
V
R
I
P
K
E
-----------
Q
G
F
L
S
F
W
R
---------
G
N
L
A
N
V
I
R
-----------
Y
F
P
-------------------------
T
Q
A
L
N
---
F
A
---
F
K
D
------
K
Y
--
K
------
Q
I
F
LGGVDRHKQ
F
W
R
----
Y
F
-----
A
G
---
N
L
A
S
G
G
-----------------------
A
A
G
A
T
S
L
C
F
V
Y
---
P
L
D
-----
F
A
R
----------------
T
R
L
A
A
D
V
G
K
G
A
A
Q
R
E
F
T
G
L
G
N
--------------------------------------------
C
I
T
K
----
I
----
F
K
S
-
D
G
L
R
G
L
Y
Q
-------------
G
F
N
V
S
V
Q
----
G
I
I
--------
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
----
M
L
P
--------
D
P
K
N
V
-
H
I
I
V
S
W
--
M
I
----------
A
Q
----
T
V
T
A
V
A
G
L
V
S
-
Y
P
-
F
D
T
-
V
R
R
R
M
-----
M
M
Q
S
GR
K
--------
G
---
A
D
-----
I
M
YTG
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
--
L
V
L
-
Y
D
E
I
---------------------------------------------------
29
Fugue
80.33
21%
-71
- C6 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
---
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
-----
A
V
A
P
I
E
R
V
K
L
L
L
------
Q
V
Q
--------
H
ASKQIS
A
E
---------
K
Q
Y
---
K
G
-
I
I
D
C
V
V
R
I
P
K
E
-----------
Q
G
F
L
S
F
W
R
---------
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
-
L
---
N
F
A
-------------------------
F
K
D
K
Y
---
K
Q
---
I
F
L
GGVDRH
K
Q
--
F
------
W
-------------
R
----
Y
F
-----
A
G
---
N
L
A
S
G
G
-----------------------
A
A
G
A
T
S
L
C
F
V
Y
---
P
L
D
-----
F
A
R
----------------
T
R
L
A
A
D
-
V
G
K
G
A
A
Q
R
-------------
E
------------------------------
F
T
G
L
G
N
C
I
T
K
----
I
----
F
K
S
-
D
G
L
R
G
L
Y
Q
-------------
G
F
N
V
S
V
Q
----
G
I
I
--------
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
----
M
L
P
---------
D
P
K
N
V
H
I
I
V
S
W
--
M
I
----------
A
Q
----
T
V
T
A
V
A
G
L
V
S
-
Y
P
-
F
D
T
-
V
R
R
R
M
-----
M
M
Q
S
--
G
RKGADIMY
T
---
G
T
-----
V
D
------
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
--
L
V
L
-
Y
D
E
I
---------------------------------------------------
20
HHSearch
78.41
21%
-71
- C6 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
---
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
-----
A
V
A
P
I
E
R
V
K
L
L
L
------
Q
V
Q
--------
H
------
A
S
KQISAE---
K
Q
Y
---
K
G
-
I
I
D
C
V
V
R
I
P
K
E
-----------
Q
G
F
L
S
F
W
R
---------
G
N
L
A
N
V
I
R
Y
F
P
-
T
Q
A
L
---
N
F
A
-------------------------
F
K
D
K
Y
---
K
Q
---
I
F
L
------
G
G
--
V
DRHKQ
F
W
-------------
R
----
Y
F
-----
A
G
---
N
L
A
S
G
G
-----------------------
A
A
G
A
T
S
L
C
F
V
Y
---
P
L
D
-----
F
A
R
----------------
T
R
L
A
A
D
-
V
G
K
G
A
A
-------------
Q
R
E
------------------------------
F
T
G
L
G
N
C
I
T
K
----
I
----
F
K
S
-
D
G
L
R
G
L
Y
Q
-------------
G
F
N
V
S
V
Q
----
G
I
I
--------
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
----
M
L
P
------
D
P
K
N
---
V
H
I
I
V
S
W
--
M
I
----------
A
Q
----
T
V
T
A
V
A
G
L
V
S
-
Y
P
-
F
D
T
-
V
R
R
R
M
-----
M
M
Q
S
--
G
RKGADIMY
T
---
G
T
-----
V
D
------
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
-
G
A
F
--
V
L
V
L
Y
D
E
I
---------------------------------------------------
3
PsiBlast_PDB
77.70
22%
-78
- C6 -
4C9J
4
ADT3_YEAST
A:
[71-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---
S
G
-
I
V
D
C
F
K
R
T
A
K
Q
-----------
E
G
L
I
S
F
W
R
---------
G
N
T
A
N
V
I
R
Y
F
P
-
T
Q
-
A
---
L
N
F
-------------------------
A
F
K
D
K
---
I
K
---
L
M
F
------
G
F
--
K
------
K
-------------
E
----
E
G
Y
G
K
W
F
A
G
---
N
L
A
S
G
G
-----------------------
A
A
G
A
L
S
L
L
F
V
Y
---
S
L
D
-----
F
A
R
----------------
T
R
L
A
A
D
-
A
K
S
----------------
A
R
Q
------------------------------
F
N
G
L
T
D
V
Y
K
K
----
T
----
L
K
S
-
D
G
I
A
G
L
Y
R
-------------
G
F
M
P
S
V
V
----
G
I
V
------------
V
Y
R
G
L
Y
F
G
M
F
D
----
S
L
K
--------------------F-
L
L
----------
G
W
----
V
V
T
T
G
A
S
T
C
S
-
Y
P
-
L
D
T
-
V
R
R
R
M
M
M
T
SG
Q
A
V
K
--
Y
--------
N
---
G
A
-----
I
D
------
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
--
I
S
M
-
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
------------------------------------------
6
PsiBlast_PDB
75.41
21%
-64
- C6 -
4C9H
5
ADT2_YEAST
A:
[67-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---
A
G
-
I
L
D
C
F
K
R
T
A
T
Q
-----------
E
G
V
I
S
F
W
R
---------
G
N
T
A
N
V
I
R
Y
F
P
-
T
Q
-
A
---
L
N
F
-------------------------
A
F
K
D
K
---
I
K
---
A
M
F
------
G
F
--
K
------
K
-------------
E
----
E
G
Y
A
K
W
F
A
G
---
N
L
A
S
G
G
-----------------------
A
A
G
A
L
S
L
L
F
V
Y
---
S
L
D
-----
Y
A
R
----------------
T
R
L
A
A
D
-
S
------------------
A
R
Q
------------------------------
F
N
G
L
I
D
V
Y
K
K
----
T
----
L
K
S
-
D
G
V
A
G
L
Y
R
-------------
G
F
L
P
S
V
V
----
G
I
V
--------
V
Y
R
G
L
Y
F
G
M
Y
----
D
----
S
L
K
------------------
L
A
S
F
L
L
----------
G
W
----
V
V
T
T
G
A
S
T
C
S
-
Y
P
-
L
D
T
-
V
R
R
R
M
-----
M
M
T
S
--
G
--------
Q
---
A
V
KYDG
A
F
D
------
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
G
V
A
G
A
G
V
--
I
S
M
-
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
-----------------------------------------
4
PsiBlast_PDB
70.79
22%
-83
- C6 -
4C9Q
5
ADT3_YEAST
A:
[71-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---
S
G
-
I
V
D
C
F
K
R
T
A
K
Q
-----------
E
G
L
I
S
F
W
R
---------
G
N
T
A
N
V
I
R
Y
F
P
-
T
Q
-
A
---
L
N
F
-------------------------
A
F
K
D
K
---
I
K
---
L
M
F
------
G
F
--
K
------
K
-------------
E
-----
G
Y
G
K
W
F
A
G
---
N
L
A
S
G
G
-----------------------
A
A
G
A
L
S
L
L
F
V
Y
---
S
L
D
-----
F
A
R
----------------
T
R
L
A
A
D
-
A
K
S
----------------
A
R
Q
------------------------------
F
N
G
L
T
D
V
Y
K
K
----
T
----
L
K
S
-
D
G
I
A
G
L
Y
R
-------------
G
F
M
P
S
V
V
----
G
I
V
------------
V
Y
R
G
L
Y
F
G
M
F
D
----
S
L
K
------
P
L
---------
F
L
A
S
F
L
L
----------
G
W
----
V
V
T
T
G
A
S
T
C
S
-
Y
P
-
L
D
T
-
V
R
R
R
M
M
M
T
SG
Q
A
V
K
--
Y
--------
N
---
G
A
-----
I
D
------
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
--
I
S
M
-
Y
D
Q
L
Q
M
I
L
F
G
K
--------------------------------------------
31
Fugue
70.60
14%
-68
- C3 -
3P0S
-
?
A:
[43-454]
---------------------------------------------------------------------------
A
N
D
G
R
Q
D
I
F
S
---
G
--
A
P
Q
P
N
Q
H
---
H
T
L
V
Y
G
K
S
Y
H
F
T
I
T
N
-----
G
L
P
E
F
R
H
L
A
T
T
N
------
S
G
Y
--------
Y
------
A
Q
---------
Q
R
F
KH
I
H
G
I
P
W
E
R
L
L
M
Y
V
S
E
-----------
G
E
L
L
R
M
F
R
---------
D
Y
T
S
L
K
V
E
E
V
V
-
C
E
-
V
---
Y
S
L
G
V
R
L
P
FVTSATTSSVANANAQ
Y
P
I
G
C
F
H
F
D
---
E
A
---
Y
E
T
------
N
Y
G
I
N
------
N
-------------
V
----
A
D
-----
I
I
---
N
K
A
L
G
T
EWKNATRPTAA
V
T
T
A
W
SEQFPNI
S
A
S
S
T
S
R
D
I
N
N
---
P
V
I
-----
V
D
Y
S
LPYF
E
N
N
V
P
K
DVGIY
D
Y
V
D
I
K
-
N
G
T
T
A
Y
G
K
C
W
E
K
R
F
K
P
T
N
G
L
L
Y
AESTLKGNVVTPLAAQPTN
I
M
T
P
I
PGLENG
Y
F
M
S
N
D
Q
I
R
E
---------
R
R
D
-
L
T
T
S
V
P
P
V
-------------
A
L
T
A
T
K
L
NQS
A
S
N
N
--------
L
N
A
F
V
D
Y
M
G
Y
N
Y
F
G
E
----
Q
K
C
------
A
--
P
Q
S
M
P
K
F
M
I
G
F
--
V
N
----------------
I
R
N
E
D
N
S
L
L
N
-
A
K
-
W
D
I
L
I
K
T
R
I
-----
R
L
T
G
--
L
--------
Q
---
S
T
-----
R
E
------
W
V
A
R
--
T
D
R
I
P
P
Q
Y
F
T
S
Q
Y
T
Q
F
R
Y
P
N
I
N
E
T
P
--
L
L
R
S
L
G
T
F
K
L
P
T
K
R
P
G
M
D
S
R
I
A
A
------------------------------------
30
Fugue
69.08
17%
-78
* C4 *
4ES8
1
?
A:
[19-320]
---------------------------------------------------------------------------
E
E
L
P
D
D
L
M
N
F
---
K
GT
W
E
V
S
A
D
G
S
S
G
R
F
F
S
K
G
A
-------
T
-----
D
S
Y
V
F
H
L
I
P
A
K
D
------
V
K
K
--------
P
------
G
W
---------
R
E
H
---
N
E
-
V
K
D
S
Y
I
K
I
D
K
------------
Q
S
I
A
A
R
Y
K
TSTTAP
Y
S
V
A
F
K
V
N
T
K
S
L
I
K
-
D
H
-
D
---
Y
K
I
-------------------------
T
F
E
Q
G
---
Q
I
ASG
I
T
V
------
D
Y
--
R
------
I
-------------
G
S
A
FN
K
T
-----
T
D
---
D
S
F
K
I
S
-----------------------
D
E
S
K
Y
A
S
N
V
K
I
---
E
G
E
-------
E
----------------
Q
G
F
K
Q
R
-
E
Q
G
D
K
T
I
S
F
R
T
L
-
K
E
G
P
M
S
L
V
L
------------------------------
L
S
K
V
E
K
K
P
Q
-----------------
G
D
L
D
V
-------------
E
F
K
N
L
K
I
----
I
D
V
--------
T
N
P
S
Q
L
D
K
G
V
A
Y
V
G
N
----
K
----------------
N
V
Q
L
T
L
--
K
S
----------
D
D
GRTN
F
E
G
D
E
I
S
L
F
N
-
S
R
-
G
E
L
-
L
Q
T
V
T
-----
V
T
K
D
--
Q
--------
Q
NP
I
S
I
-----
T
L
------
S
E
D
Q
A
K
S
L
K
N
K
E
K
L
K
V
S
I
K
Q
K
Q
S
K
K
T
S
K
D
F
F
--
F
E
V
G
I
D
P
K
V
E
A
K
-----------------------------------------------
34
Fugue
65.12
16%
-87
* C5 *
4QFR
3
AAKG1_RAT
C:
[28-322]
-----------------------------------------------------------------------Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
---
P
------
T
S
S
---
K
L
V
V
F
D
T
--
S
L
Q
V
K
K
-----
A
F
F
A
L
V
T
N
G
V
R
-------------------------
A
A
---------
P
L
W
---
D
S
-
K
K
Q
S
F
V
G
M
L
T
I
-----------
T
D
F
I
N
I
L
H
---------
R
Y
Y
K
S
A
L
V
Q
I
--------------------------------------
Y
E
L
E
---
E
H
---
K
I
E
------
T
W
--
R
------
E
-------------
V
----
Y
L
-----
Q
D
---
S
F
----------------------------
K
P
L
V
C
I
S
P
N
A
---
S
L
F
-----
D
A
V
----------------
S
S
L
I
R
N
-----
K
I
H
R
L
P
V
I
-
D
P
E
S
G
N
T
L
Y
------------------------------
I
L
T
H
K
R
I
L
K
F
----
L
----
K
L
F
I
T
S
L
E
E
L
Q
I
-------------
G
T
Y
A
N
I
A
----
M
V
R
--------
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
----
R
V
S
------
A
L
P
V
V
D
E
K
G
R
V
V
D
I
--
Y
S
----------
K
F
----
D
V
I
N
L
A
A
E
K
T
Y
N
N
-
L
D
V
------------------------------
S
V
-----
T
K
------
A
L
Q
H
R
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
--
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
-------------------------------------
19
HHSearch
61.39
19%
-58
- C6 -
2LCK
-
UCP2_MOUSE
A:
[14-304]
-------------------------------------------------------------------------------------------------
T
---
V
K
F
L
G
A
G
T
A
A
C
I
A
D
L
-----
I
T
F
P
L
D
T
A
K
V
R
L
------
Q
I
Q
--------
G
------
E
S
QG
L
V
R
T
A
AS
A
Q
Y
---
R
G
-
V
L
G
T
I
L
T
M
V
R
T
-----------
E
G
P
R
S
L
Y
N
---------
G
L
V
A
G
L
Q
R
Q
M
S
-
F
A
S
V
---
R
I
G
-------------------------
L
Y
D
S
V
---
K
Q
---
F
Y
T
------
K
G
--
S
E-----
H
-------------
A
----
G
I
-----
G
S
---
R
L
L
A
G
S
-----------------------
T
T
G
A
L
A
V
A
V
A
Q
---
P
T
D
-----
V
V
K
----------------
V
R
F
Q
A
Q
-
A
R
A
G
G
--------------
G
R
R
------------------------------
Y
Q
S
T
V
E
A
Y
K
T
----
I
----
A
R
E
-
E
G
I
R
G
L
W
K
-------------
G
T
S
P
N
V
A
----
R
N
A
--------
I
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
----
T
L
L
------
K
A
N
L
M
T
-
D
D
L
P
C
H
F
--
T
S
----------
A
F
----
G
A
G
F
C
T
T
V
I
A
-
S
P
-
V
D
V
-
V
K
T
R
Y
-----
M
N
S
A
--
L
GQY-----
H
---
S
A
-----
G
H
------
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
V
V
--
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
E
A
P
F
------------------------------------
22
HHSearch
60.97
25%
-71
- C6 -
1OKC
9
ADT1_BOVIN
A:
[111-293]
-----------------------------------------------------------------------------------------------
Y
F
A
---
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
-----
F
V
Y
P
L
D
F
A
R
T
R
L
------
A
A
D
--------
V
------
G
K
GAAQ-----
R
E
F
---
T
G
-
L
G
N
C
I
T
K
I
F
K
S
-----------
D
G
L
R
G
L
Y
Q
---------
G
F
N
V
S
V
Q
G
I
I
I
-
Y
R
A
A
---
Y
F
G
-------------------------
V
Y
D
T
A
---
K
G
---
M
L
P
------
D
P
--
K
------
N
-------------
V
----
H
I
-----
I
V
---
S
W
M
I
A
Q
-----------------------
T
V
T
A
V
A
G
L
V
S
Y
---
P
F
D
-----
T
V
R
----------------
R
R
M
M
M
Q
-
S
G
R
K
G
A
-------------
D
I
M
------------------------------
Y
T
G
T
V
D
C
W
R
K
----
I
----
A
K
D
-
E
G
P
K
A
F
F
K
-------------
G
A
W
S
N
V
L
----
R
G
M
--------
G
-
G
A
F
V
L
V
L
Y
D
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.40
25%
-51
- C6 -
2LCK
-
UCP2_MOUSE
A:
[14-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
V
K
---
F
L
G
A
G
------------------------
T
A
A
C
I
A
D
L
I
T
F
---
P
L
D
-----
T
A
K
----------------
V
R
L
Q
I
Q
---
G
E
S
Q
G
L
V
R
T
A
A
S
A
Q
Y
R
G
V
L
G
------------------------------------
T
I
L
T
----
M
----
V
R
T
-
E
G
P
R
S
L
Y
N
-------------
G
L
V
A
G
L
Q
----
R
Q
M
--------
S
F
A
S
V
R
I
G
L
Y
D
--
S
V
----
K
Q
F
------
Y
T
K
G
S
E
H
A
G
I
G
S
R
L
--
L
A
----------
G
S
----
T
T
G
A
L
A
V
A
V
A
-
Q
P
-
T
D
V
-
V
K
V
R
F
-----
Q
A
Q
A
--
R
AGGGRRY-
Q
---
S
T
-----
V
E
------
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
--
E
L
V
T
Y
D
L
I
K
D
T
L
L
K
A
N
L
M
T
D
D
L
P
------------------------------------
38
Fugue
58.26
9%
-71
- C1 -
2BA9
2
?
A:
[2-424]
SISKDSR
I
A
I
I
G
AG
P
A
G
L
A
A
G
M
Y
L
E
Q
A
GFHD
Y
T
I
L
E
RTDHVGGKC
H
S
P
N
Y
HG
R
R
Y
E
MGAIMGVPSY
D
T
I
Q
E
I
M
D
R
T
G
D
K
V
D
G
P
K
L
---
R
--
R
E
F
L
H
E
D
---
G
E
I
Y
V
P
E
K
D
P
V
R
G
P
Q
-----
V
M
A
A
V
Q
K
L
G
Q
L
L
------
A
T
K
YQGYDANG
H
------
Y
N
---------
K
V
H
---
E
D
-
L
M
L
P
F
D
E
F
L
A
L
-----------
N
G
C
E
A
A
R
D
---------
L
W
I
N
P
F
T
A
F
G
Y
-
G
H
-
F
---
D
N
V
-------------------------
P
A
A
Y
V
---
L
K
---
Y
L
D
------
F
V
--
T
------
M
-------------
M
----
S
F
-----
A
K
GD
L
W
T
W
A
D
G
-----------------------
T
Q
A
M
F
E
H
L
N
A
T
LEH
P
A
E
-----
R
N
V
----------------
D
I
T
R
I
T
-
R
E
D
G
K
V
H
I
H
T
T
D
W
D
R
E
S
D
V
L
V
L
------------------------------
T
V
P
L
E
K
F
L
D
Y
----
S
DAD
D
D
E
R
-
E
Y
F
S
K
I
I
H
-------------
Q
Q
Y
M
V
D
A
----
C
L
V
KEY-----
P
T
I
S
G
Y
V
P
D
N
M
R
P
E
R
LGHV
M
V
Y
------
Y
H
R
W
A
D
D
P
H
Q
I
I
T
T
--
Y
L
L
RNHPDYA--
D
K
----
T
Q
E
E
C
R
Q
M
V
L
-
D
D
-
M
E
T
-
F
G
H
P
V
-----
E
K
I
I
--
E
--------
E
---
Q
T
-----
W
Y
------
Y
F
P
H
V
S
S
E
D
Y
K
A
G
W
Y
E
K
V
E
G
--
M
Q
G
R
R
N
T
F
Y
A
G
E
I
M
S
F
G
N
F
D
E
V
C
H
Y
S
K
D
L
V
T
R
F
F
V-----------------------------------
32
Fugue
55.97
14%
-85
- C2 -
3J9O
-
?
B:
[79-505]
-----------------------------------------------------------------------V
I
D
K
L
I
D
L
Q
V
N
S
I
I
S
ND
E
--
F
R
A
L
E
Q
E
---
W
L
K
V
Q
E
V
C
Q
E
D
Y
D
N
V
-----
E
V
S
I
L
D
V
K
K
E
E
L
------
Q
Y
D
--------
F
------
E
R
---------
N
L
Y
---
D
I
-
S
S
S
D
F
F
K
K
V
Y
V
SEFDQYG
G
E
P
Y
G
A
I
L
G
L
Y
N
F
E
NT
T
N
D
--
I
I
W
L
T
G
M
G
M
V
A
-
K
N
-
S
H
A
P
F
I
A
-------------------------
S
I
D
K
S
FFG
V
K
---
D
L
S
------
E
I
--
T
------
H
-------------
I
----
K
S
-----
F
E
---
A
L
L
E
H
P
-----------------------
R
Y
K
E
W
N
D
F
R
N
L
---
D
V
A
AY
I
G
L
T
V
G
----------------
D
F
M
L
R
Q
-
P
Y
N
P
E
N
N
P
V
Q
Y
K
L
M
E
G
F
N
E
F
V
D
------------------------------
Y
D
K
N
E
S
Y
L
W
G
P
A
S
I
H
----
L
V
K
-
N
M
M
R
S
Y
D
K
TRWFQYIRGVESG
G
Y
V
K
N
L
V
----
A
C
V
Y
D
NKGIL
E
T
K
S
P
L
N
V
L
F
A
D
Y
M
E
L
----
S
L
A
N
I
GLIP
F
V
S
E
K
G
T
S
N
A
C
F
F
S
--
V
N
SAKKVEEFVD
G
F
----
D
S
A
N
S
R
L
I
A
N
-
L
S
-
Y
T
M
-
C
I
S
R
I
-----
S
H
Y
I
--
K
--------
C
---
V
I
-----
R
D
------
K
I
G
S
I
V
D
V
E
S
I
Q
K
I
L
S
D
W
I
S
E
F
V
T
T
V
Y
Q
P
T
P
--
L
E
M
A
R
Y
P
F
R
N
V
S
I
E
V
K
T
I
P
G
K
P
G
W
Y
S
C
K
I
N
V
I
P
HIQFE
G
M
N
T
T
M
T
IDTRLEPELFGTNN
7
PsiBlast_PDB
53.10
21%
-74
- C6 -
4KKM
-
?
A:
[82-234]
--------------------------------------------------------------------------------------------------------
L
F
N
V
D
R
E
A
A
L
R
V
G
M
A
I
E
C
I
H
V
Y
S
L
I
H
D
D
M
PCMDND
D
L
R
--------
R
------
G
K
---------
P
T
V
---
H
K
-
A
F
D
D
A
S
A
V
L
S
G
-----------
D
A
L
Q
A
L
----------------
A
F
E
I
L
S
-
E
E
-
K
---
I
H
T
-------------------------
D
P
H
V
R
---
L
E
---
L
I
Q
------
A
L
--
A
------
I
-------------
A
----
S
G
-----
K
D
---
G
M
V
G
G
Q
-----------------------
A
I
D
L
A
A
E
T
S
T
V
---
P
F
D
-----
L
P
T
----------------
I
T
R
L
Q
Q
-
L
K
T
G
A
L
F
G
F
C
L
E
A
-----
G
A
I
M
------------------------------
G
R
Q
N
K
D
-
I
R
D
----
R
----
L
K
A
-
Y
A
R
D
I
G
L
A
-------------
F
Q
I
A
D
D
L
----
I
D
A
--------
G
K
A
T
F
L
S
L
L
G
L
E
K
A
R
----
S
Q
A
------
Q
A
L
V
D
Q
A
I
A
H
L
S
V
F
--
G
S
----------
E
A
----
D
Y
L
R
S
I
A
R
Y
I
-
V
A
---------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
49.19
21%
-87
- C5 -
3BT3
-
?
A:
[134-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
G
Y
V
V
R
E
N
G
P
V
Y
F
T
K
D
------------------------------
M
D
K
T
V
K
W
F
E
E
----
I
----
L
------------------------
G
W
S
G
D
I
V
----
A
R
D
--------
D
E
G
F
G
D
Y
G
C
V
F
D
Y
P
S
----
E
V
A
----------
V
A
H
P
F
R
G
F
H
L
--
F
K
----------
G
E
----
P
I
K
G
V
A
G
F
M
M
-
I
E
G
I
D
A
-
L
H
K
Y
V
-----
K
E
N
G
--
W
--------
D
---
Q
I
-----
S
D
------
I
Y
T
Q
------
P
W
G
------
A
R
E
C
S
I
T
T
T
D
G
C
--
I
L
R
F
F
E
S
I
---------------------------------------------------
21
HHSearch
46.65
21%
-45
- C6 -
2LCK
-
UCP2_MOUSE
A:
[113-302]
---------------------------------------------------------------------------------------------
H
A
G
I
G
---
S
R
L
L
A
G
S
T
T
G
A
L
A
V
A
-----
V
A
Q
P
T
D
V
V
K
V
R
F
------
Q
A
Q
--------
A
------
R
A
GGG------
R
R
Y
---
Q
S
-
T
V
E
A
Y
K
T
I
A
R
E
-----------
E
G
I
R
G
L
W
K
---------
G
T
S
P
N
V
A
R
N
A
I
-
V
N
C
A
---
E
L
V
-------------------------
T
Y
D
L
I
---
K
D
---
T
L
L
------
K
A
--
N
LM----
T
-------------
D
----
D
L
-----
P
C
---
H
F
T
S
A
F
-----------------------
G
A
G
F
C
T
T
V
I
A
S
---
P
V
D
-----
V
V
K
----------------
T
R
Y
M
N
S
-
A
L
------------------
G
Q
------------------------------
Y
H
S
A
G
H
C
A
L
T
----
M
----
L
R
K
-
E
G
P
R
A
F
Y
K
-------------
G
F
M
P
S
F
L
----
R
L
G
--------
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
----
A
L
M
------
A
A
Y
Q
S
R
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
42.16
25%
-54
- C6 -
1JQN
1
CAPP_ECOLI
A:
[467-541]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
-----------------------
I
A
A
Y
V
I
S
M
A
K
T
---
P
S
D
-----
V
L
A
----------------
V
H
L
L
L
K
-
E
A
G
--
I
G
-
F
A
M
P
V
A
P
L
F
E
T
L
D
D
------------------------------
L
N
N
A
N
D
V
M
T
Q
----
L
----
L
N
I
-
D
W
Y
R
G
L
I
Q
-------------
G
K
Q
M
V
M
I
----
G
Y
S
--------
D
S
A
K
D
A
G
V
M
A
A
S
W
A
Q
----
Y
Q
A
------
Q
D
A
L
I
K
T
C
E
K
A
G
I
E
--
L
T
----------
L
F
----
H
G
R
G
G
S
I
G
R
G
-
G
A
-
P
A
H
-
A
A
L
L
S
-----
Q
P
P
G
--
S
--------
L
---
K
G
-----
G
L
------
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
P
E
I
T
V
S
S
L
S
L
Y
T
G
A
I
L
--
E
A
N
L
L
P
P
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
------------------------------------
10
PsiBlast_PDB
41.49
25%
-53
- C6 -
1FIY
-
CAPP_ECOLI
A:
[467-541]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
-----------------------
I
A
A
Y
V
I
S
M
A
K
T
---
P
S
D
-----
V
L
A
----------------
V
H
L
L
L
K
-
E
A
G
--
I
G
-
F
A
M
P
V
A
P
L
F
E
T
L
D
D
------------------------------
L
N
N
A
N
D
V
M
T
Q
----
L
----
L
N
I
-
D
W
Y
R
G
L
I
Q
-------------
G
K
Q
M
V
M
I
----
G
Y
S
--------
D
S
A
K
D
A
G
V
M
A
A
S
W
A
Q
----
Y
Q
A
------
Q
D
A
L
I
K
T
C
E
K
A
G
I
E
--
L
T
----------
L
F
----
H
G
R
G
G
S
I
G
R
G
-
G
A
-
P
A
H
-
A
A
L
L
S
-----
Q
P
P
G
--
S
--------
L
---
K
G
-----
G
L
------
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
P
E
I
T
V
S
S
L
S
L
Y
T
G
A
I
L
--
E
A
N
L
L
P
P
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
------------------------------------