@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2552_HUMAN: (2015-12-09 )
MIDSEAHEKRPPILTSSKQDISPHITNVGEMKHYLCGCCAAFNNVAITYPIQKVLFRQQLYGIKTRDAVLQLRRDGFRNLYRGILPPLMQKTTTLALMFGLYEDLSCLLRKHVRAPEFATHGVAAVLAGTAEAIFTPLERVQTLLQNHKHHDKFTNTYQAFKALKCHGIGEYYRGLVPILFRNGLSNVLFFGLRGPIKEHLPTATTHSAHLVNDFIGGGLLGAMLGFLCFPINVVKTRLQSQIGGEFQSFPKVFQKIWLERDRKLINLFRGAHLNYHRSLISWGIINATYEFLLKFI
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..----.......10....--.---------...20.--.....--------..30-----.........40.......--.50...----..---.--..60-..-----..--------------....----------.70-.-..-...----..80--.......-.90-------..-.....---------..100.----......--110------.-----.-.....120..-.--.-----...-130....-...---.140.....--..150-----.---------.---.......-----160-.------------.--------..----.-..170.......180--........---.190.-------.--....--.--200.------....---.----.-------------..210..--------------------------...----..220-.--.......230.......----.-----240.-------...---.-----..-------..250......--.260-......-------------.270----.......280------..---.....290.....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI----DSEAHEKRPPILT--S---------SKQDIS--PHIT
N
--------
V
G
E
------
M
K
H
Y
L
C
G
C
C
A
A
FNN
V
A
I
T
--
Y
P
I
Q
K
V
----
L
F
---
R
--
Q
Q
L--YG-----I
K
--------------
T
R
D
A
----------
V
L
Q
-
L
-
R
R
-
D
G
F
----
R
N
L
Y
--
R
G
IL
P
P
L
-
M
Q
--------
K
T
-
T
T
L
A
L
---------
M
F
G
L
Y
E
----
D
L
S
C
L
L
--
R
KH------V-----R-AP
E
F
A
T
H
G
V
A
-
A
--
V
-----
L
AG-
T
-
A
E
A
I
F
-
T
P
L
---
E
R
V
Q
T
L
L
Q
N--HK
H
-------
H
---------
D
---
K
F
T
N
T
Y
Q
-----
A
F
K
-
A
------------
L
--------
K
C----H-
G
I
G
E
Y
Y
R
G
L
V
P
I
L
----
F
RNG
L
S
N
V
---
L
F
FGL-------R--G
P
I
K
--
E
--H--L------PTAT---T----H-------------
S
A
H
L
V
N
D
--------------------------FIG----
G
G
L
L
--
G
--
A
M
L
G
F
L
CF-
P
I
N
V
V
K
T
R
----
L
-----
Q
--
S
-------
Q
IG---
G
-----
E
F
-------
Q
S
F
P
K
V
F
Q
K
I
W
--
L
E
R
D
-
R
K
L
I
N
L
-------------
F
R
GA----H
L
N
Y
H
R
S
L
I
S
------
W
G
---
I
I
N
A
T
Y
E
F
L
L
K
FI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
85.97
22%
-62
- C2 -
1OKC
10
ADT1_BOVIN
A:
[4-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------
L
S
F
------
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
--
A
P
I
E
R
V
----
K
L
---
L
--
L
Q
V
--
Q
H
-----
A
S
KQISAEKQYKG---
I
I
D
C
----------
V
V
R
-
I
P
K
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-
Q
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----
L
S
F
W
--
R
G
N
L
A
N
V
-
I
R
--------
Y
F
-
P
T
Q
A
L
---------
N
F
A
F
K
D
----
K
Y
K
Q
I
F
--
L
G
G
------
V
DRHKQ
F
-
W
R
Y
F
A
G
N
L
A
S
-
G
--
G
-----
A
A
G
-
A
-
T
S
L
C
F
V
Y
P
L
---
D
F
A
R
T
R
L
A
A
--
D
V
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-------
K
GAAQ-----
R
---
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F
T
G
L
G
N
-----
C
I
T
-
K
------------
I
F
-------
K
S
----
D
-
G
L
R
G
L
Y
Q
G
F
N
V
S
V
----
Q
G
I
I
I
Y
R
A
---
A
Y
F
G
V
-------
Y
--
D
T
A
K
--
G
--
M
--
L
------
P
D
P
K
----------------------
N
V
H
I
I
V
S
--------------------------
W
M
I
----
A
Q
T
V
--
T
--
A
V
A
G
L
V
S
Y
-
P
F
D
T
V
R
R
R
----
M
-----
M
--
M
-------
Q
S
G
---
R
KGADI
M
Y
-------
T
G
T
V
D
C
W
R
K
I
A
--
K
D
E
G
---
P
K
A
F
-------------
F
K
G
A
----
W
S
N
V
L
R
G
M
G
-------
G
A
---
F
V
L
V
L
Y
D
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
77.30
21%
-87
* C4 *
4N5H
3
?
X:
[1-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADEEAMLA
K
V
----
Q
A
S
W
A
Q
T
A
A
R
D
K
A
--
R
---------
Y
A
D
E
R
V
--
P
E
--
D
--------
V
H
W
------
E
T
E
Y
R
------
Y
E
Q
S
A
D
P
--
Q
Q
T
L
N
L
----
Y
Y
---
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--
A
K
R
--
R
N
------
A
--------------
T
M
P
T
----------
V
I
D
-
I
-
H
G
-
G
G
W
FYGD
R
N
L
N
--
R
N
Y
C
R
Y
L
-
A
S
--------
Q
G
Y
A
V
M
G
M
GYRLLPDVD
L
R
G
Q
I
Q
----
D
I
F
A
S
L
--
R
W
L
------
S
-----
H
F
G
P
Q
R
G
F
D
L
D
H
-
V
--
L
-----
L
T
G
D
S
-
A
G
G
H
L
-
A
S
L
-----
V
A
C
I
Q
Q
S
--
A
E
L
-------
Q
---------
E
---
L
F
G
V
S
R
V
-----
N
F
-------------------------------------------------------
N
F
---
T
L
V
A
L
-------
V
--
C
P
V
A
EP
S
--
K
--
L
------
P
E
A
A
GDM
S
----
D
-------------
M
A
A
F
Y
L
D
--------------------------
K
L
S
----
G
G
D
---
Q
--
A
L
V
D
H
L
N
F
-
S
Q
V
V
K
G
L
D
----
L
-----
P
PF
M
-------
L
I
G
---
G
-----
Q
N
DSFYLQS
Q
A
L
L
K
V
F
D
A
N
H
--
V
T
Y
T
-
T
K
L
W
P
A
-------------
S
A
G
P
----
H
L
K
H
V
F
N
V
Q
H
------
W
E
WPE
S
I
E
T
N
L
E
M
L
R
T
F
D
ALSKQQDQAEENE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.46
25%
-73
- C2 -
4C9Q
4
ADT3_YEAST
A:
[28-196]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
N
F
L
M
G
G
V
S
-
A
--
A
-----
I
A
K
-
T
-
A
A
----
S
P
I
---
E
R
V
K
I
L
I
Q
N
--
Q
D
E
M
I
K
Q
GTL
D
---------
K
---
K
Y
S
G
I
V
D
-----
C
F
K
R
T
------------
A
--------
K
Q
----
E
-
G
L
I
S
F
W
R
G
N
T
A
N
V
----
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
--
D
K
I
K
--
L
M
F
G
--
F
------
K
K
E
----
G
----
Y
-------------
G
K
W
F
A
G
N
--------------------------
L
A
S
----
G
G
A
A
--
G
--
A
L
S
L
L
F
V
Y
-
S
L
D
F
A
R
T
R
----
L
A
A
DAK
S
-----------------AR---
Q
F
-------
N
G
L
T
D
V
Y
K
K
T
---
L
K
S
D
--
G
I
A
G
L
-------------
Y
R
G
F
----
M
P
S
V
V
G
I
V
V
Y
------
R
G
---
L
Y
F
G
M
F
D
S
L
K
P
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.07
25%
-76
- C2 -
4C9H
4
ADT2_YEAST
A:
[26-192]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
M
G
G
V
S
-
A
--
A
-----
V
A
K
-
T
-
A
A
----
S
P
I
---
E
R
V
K
L
L
I
Q
N
--
Q
D
E
M
L
K
Q
GTL
D
---------
R
---
K
Y
A
G
I
L
D
-----
C
F
K
-
R
------------
T
--------
A
T
----
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
----
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
--
D
K
I
K
--
A
--
M
F
G
F
------
K
K
E
E
---
G
----
Y
-------------
A
K
W
F
A
G
N
--------------------------
L
A
S
----
G
G
A
A
--
G
--
A
L
S
L
L
F
V
Y
-
S
L
D
Y
A
R
T
R
----
L
A
A
DS-------------------AR---
Q
F
-------
N
G
L
I
D
V
Y
K
K
T
---
L
K
S
D
--
G
V
A
G
L
-------------
Y
R
G
F
----
L
P
S
V
V
G
I
V
V
Y
------
R
G
---
L
Y
F
G
M
Y
D
S
L
K
L
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
73.12
22%
-63
- C2 -
2LCK
-
UCP2_MOUSE
A:
[14-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
K
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
--
F
P
L
D
T
A
----
K
V
---
R
--
L
Q
I
--
Q
G
-----
E
S
QG
L
V
R
T
A
ASAQYRG
V
L
G
T
----------
I
L
T
-
M
V
R
T
-
E
G
P
----
R
S
L
Y
--
N
G
L
V
A
G
L
-
Q
R
--------
Q
M
-
S
F
A
S
V
---------
R
I
G
L
Y
D
----
S
V
K
Q
F
Y
--
T
K
G
------
S
-----
E
-
H
A
G
I
G
S
R
L
L
A
-
G
--
S
-----
T
T
G
-
A
-
L
A
V
A
V
A
Q
P
T
---
D
V
V
K
V
R
F
Q
A
--
Q
A
R
-------
A
GGG------
R
---
R
Y
Q
S
T
V
E
-----
A
Y
K
-
T
------------
I
A-------
R
E
----
E
-
G
I
R
G
L
W
K
G
T
S
P
N
V
----
A
R
N
A
I
V
N
C
---
A
E
L
V
T
-------
Y
--
D
L
I
K
--
D
--
T
--
L
------
L
K
A
N
---
L
----
M
-------------
T
D
D
L
P
C
H
--------------------------
F
T
S
----
A
F
G
A
--
G
--
F
C
T
T
V
I
A
S
-
P
V
D
V
V
K
T
R
----
Y
-----
M
--
N
-------
S
A
L
---
G
-----
Q
Y
-------
H
S
A
G
H
C
A
L
T
M
L
--
R
K
E
G
---
P
R
A
F
-------------
Y
K
G
F
----
M
P
S
F
L
R
L
G
S
W
------
N
V
---
V
M
F
V
T
Y
E
Q
L
K
R
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.85
25%
-79
- C2 -
4C9J
4
ADT3_YEAST
A:
[28-196]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
N
F
L
M
G
G
V
S
-
A
--
A
-----
I
A
K
-
T
-
A
A
----
S
P
I
---
E
R
V
K
I
L
I
Q
N
--
Q
D
E
M
I
K
Q
GTL
D
---------
K
---
K
Y
S
G
I
V
D
-----
C
F
K
R
T
------------
A
--------
K
Q
----
E
-
G
L
I
S
F
W
R
G
N
T
A
N
V
----
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
--
D
K
I
K
--
L
M
F
G
--
F
------
K
K
E
E
---
G
----
Y
-------------
G
K
W
F
A
G
N
--------------------------
L
A
S
----
G
G
A
A
--
G
--
A
L
S
L
L
F
V
Y
-
S
L
D
F
A
R
T
R
----
L
A
A
DAK
S
-----------------AR---
Q
F
-------
N
G
L
T
D
V
Y
K
K
T
---
L
K
S
D
--
G
I
A
G
L
-------------
Y
R
G
F
----
M
P
S
V
V
G
I
V
V
Y
------
R
G
---
L
Y
F
G
M
F
D
S
L
K
F
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
72.79
17%
-33
- C2 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
--
G
---------
V
A
A
A
I
S
--
K
T
A
V
---------------------------
A
P
I
E
R
V
K
L
L
--
L
Q
V
Q
H
A
----
S
K
QIS
A
--
E
K
Q
--
Y
K
-----
G
I
--------------
I
D
C
V
----------
V
R
I
-
P
-
K
E
-
Q
G
F
----
L
S
F
W
--
R
G
N
L
A
N
V
-
I
R
--------
Y
F
-
P
T
Q
A
L
---------
N
F
A
F
K
D
----
K
Y
K
Q
I
F
--
L
G
G
VDRHKQ
F
-----
W
-
R
Y
F
A
G
N
L
A
S
G
-
G
--
A
-----
A
G
A
-
T
-
S
L
C
F
V
-
Y
P
L
---
D
F
A
R
T
R
L
A
A
--
D
V
G
-------
K
---------
G
---
A
A
Q
R
E
F
T
G
L
G
N
C
I
T
K
-
I
------------
F
--------
K
S
----
D
-
G
L
R
G
L
Y
Q
G
F
N
V
S
V
----
Q
G
I
I
I
Y
R
A
---
A
Y
F
G
V
-------
Y
--
D
T
A
K
--
G
--
M
--
L
------
P
D
-----
P
----
K
-------------
N
V
H
I
I
V
S
--------------------------
W
M
I
----
A
Q
T
V
--
T
--
A
V
A
G
L
V
S
Y
-
P
F
D
T
V
R
R
R
----
M
-----
M
--
M
-------
Q
S
G
RKG
A
-----
D
I
-------
M
Y
T
G
T
V
D
C
W
R
K
--
I
A
K
D
-
E
G
P
K
A
F
-------------
F
K
G
A
----
W
S
N
V
L
R
G
M
G
G
------
A
F
---
V
L
V
L
Y
D
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.68
25%
-79
- C2 -
4C9G
5
ADT2_YEAST
A:
[26-192]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
M
G
G
V
S
-
A
--
A
-----
V
A
K
-
T
-
A
A
----
S
P
I
---
E
R
V
K
L
L
I
Q
N
--
Q
D
E
M
L
K
Q
GTL
D
---------
R
---
K
Y
A
G
I
L
D
-----
C
F
K
-
R
------------
T
--------
A
T
----
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
----
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
--
D
K
I
K
--
A
--
M
F
G
F
------
K
K
E
E
---
G
----
Y
-------------
A
K
W
F
A
G
N
--------------------------
L
A
S
----
G
G
A
A
--
G
--
A
L
S
L
L
F
V
Y
-
S
L
D
Y
A
R
T
R
----
L
A
A
DS-------------------R----
Q
F
-------
N
G
L
I
D
V
Y
K
K
T
---
L
K
S
D
--
G
V
A
G
L
-------------
Y
R
G
F
----
L
P
S
V
V
G
I
V
V
Y
------
R
G
---
L
Y
F
G
M
Y
D
S
L
L
A
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
69.29
20%
-72
* C2 *
1OKC
8
ADT1_BOVIN
A:
[5-200]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
L
K
D
F
L
A
-
G
--
G
-----
V
A
A
-
A
-
I
S
K
T
A
V
A
P
I
---
E
R
V
K
L
L
L
Q
V
--
Q
H
A
-------
S
KQISAE---
K
---
Q
Y
K
G
I
I
D
-----
C
V
V
-
R
------------
I
P-------
K
E
----
Q
-
G
F
L
S
F
W
R
G
N
L
A
N
V
----
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
--
D
K
Y
K
--
Q
--
I
--
F
------
L
G
G
V
---
D
RHKQ
F
-------------
W
R
Y
F
A
G
N
--------------------------
L
A
S
----
G
G
A
A
--
G
--
A
T
S
L
C
F
V
Y
-
P
L
D
F
A
R
T
R
----
L
-----
A
--
A
-------
D
V
G
---
K
GAAQR
E
F
-------
T
G
L
G
N
C
I
T
K
I
F
--
K
S
D
G
---
L
R
G
L
-------------
Y
Q
G
F
----
N
V
S
V
Q
G
I
I
I
Y
------
R
A
---
A
Y
F
G
V
Y
D
T
A
K
G
M
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
69.11
20%
-87
- C1 -
4FDW
-
?
A:
[21-401]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASLEDFSIEQLPAKTIYALGENIDLTG
L
N
V
T
G
K
Y
DDG
K
Q
R
P
V
K
V
T
SE
Q
I
SGFS
S
S
V
P
V
D
K
Q
E
V
T
I
T
I
E
G
---------
K
Q
K
S
F
S
--
V
H
I
S
P
--------
V
R
V
------
E
N
G
V
L
T
E
I
L
K
G
Y
N
E
I
I
L
P
--
N
S
V
K
S
I
PKDA
F
R
---
N
--
S
Q
I
--
A
K
-----
V
V
--------------
L
N
E
G
----------
L
K
S
-
I
-
G
D
M
A
F
F
----
N
S
T
V
--
Q
E
I
V
F
P
S
-
T
L
--------
E
Q
-
L
K
E
D
I
---------
F
Y
Y
C
Y
N
LKKA
D
L
S
K
T
K
--
I
T
K
------
L
-----
P
-
A
S
T
F
V
Y
A
G
I
E
-
E
--
V
L
L
P
VT
L
K
E
-
I
-
G
S
Q
A
F
-
L
K
T
---
S
Q
L
K
T
-
I
E
I
--
P
E
N
-------
V
---------
S
---
T
I
G
Q
--
E
-----
A
F
R
-
E
-----------------------------------
S
G
I
T
T
V
K
----
L
P
N
G
V
T
N
I
ASR
A
F
Y
Y
C
-------
P
-----------
E
--
L
------
A
E
V
T
---
T
----
Y
-------------
G
S
T
F
N
D
D
PEAMIHPYCLEGCPKLA
R
F
E
I
P
ESIR
I
L
G
----
Q
G
L
L
--
G
GN
R
K
V
T
Q
L
T
I
-
P
A
N
V
T
Q
I
N
----
F
-----
S
--
A
FNNTGIK
E
V
K
---
V
-----
E
G
-------
T
T
P
P
Q
V
F
E
K
V
W
YG
F
P
D
D
-
I
T
V
I
R
V
-------------
P
A
E
S
----
V
E
K
Y
K
N
A
----------------
N
G
W
R
D
F
T
N
K
I
T
TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
68.18
14%
-78
- C1 -
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSKLGIL
L
P
S
L
L
N
S
L
P
R
F
L
D
D
GK
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
APKLFKDM
F
D
Q
I
I
Q
F
T
D
M
V
I
K
NKDLEP
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
EVSIDDDDA
A
E
W
I
E
SDDTDDEEE
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
LGGEYL
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
STE
W
R
E
R
F
A
A
M
M
A
L
S
S
A
AEGCA
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
NDPH
P
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
----
Q
R
T
A
H
D
R
I
L
P
A
L
I
--
S
K
L
TSECT
S
R
V
Q
T
H
A
A
--
A
A
L
V
N
--------
F
S
E
FASKDI
L
E
P
Y
L
D
S
L
L
T
N
L
L
V
L
L
Q
S
--
N
K
---------
L
---
Y
--
V
Q
E
--
Q
A
-----
L
T
--------------
T
I
A
F
----------
I
A
E
-
A
-
A
K
-
N
K
F
----
I
K
Y
Y
--
D
T
L
M
P
L
L
-
L
N
--------
V
L
-
K
V
N
S
V
---------
L
K
G
K
C
M
----
E
C
A
T
L
I
--
G
F
A
------
V
-----
G
-
K
E
K
F
H
E
H
---------------------------
S
---
Q
E
L
I
S
I
L
V
A
--
L
Q
N
-------
S
---------
D
---
A
L
R
S
Y
L
E
-----
Q
S
W
-
S
------------
R
--------
I
C
----
R
-
I
L
G
D
D
F
V
P
L
L
P
I
V
----
I
P
P
L
L
I
T
A
---
K
A
T
Q
D
-------
V
--
G
L
I
E
--
E
--
E
--
E
------
A
A
N
F
---
Q
----
Q
-------------
Y
P
D
W
D
V
V
--------------------------
Q
V
Q
----
G
K
-------------
H
I
-
A
I
H
T
S
V
L
D
----
D
-----
K
--
V
-------
S
A
M
---
E
-----
L
L
-------
Q
S
Y
A
T
L
L
R
G
Q
F
--
A
V
Y
V
-
K
E
V
M
E
E
-------------
I
A
L
P
----
S
L
D
F
Y
---
L
H
------
D
G
---
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
AE
E
L
V
L
L
W
H
K
A
S
S
K
L
I
G
G
L
M
S
EPM
P
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
GDNCLS
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
DRDEYNED
F
T
D
E
D
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
GHY
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
LE
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
YEQTASMKNAF
I
P
K
V
T
E
C
L
ISPD
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
YAPSTYADVCIPT
L
D
T
L
V
Q
I
V
DGSKLEEN
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
NSNIPD
T
Y
T
A
N
W
F
K
T
LPTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
61
Fugue
66.56
23%
-96
* C1 *
4FS7
2
?
A:
[2-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDFVIDE
I
T
Y
N
F
T
KEHGT
V
E
----
V
S
G
L
R
E
F
L
N
P
L
V
V
--
N
---------
I
P
P
V
V
T
Y
K
D
N
K
Y
D
--------
V
V
S
------
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
--
S
T
V
R
E
I
GEF-
A
F
---
E
NC
S
K
L
--
E
I
-----
I
N
--------------
I
P
D
S
----------
V
-
K
M
I
-
G
R
-
C
T
F
----
S
G
C
Y
AL
K
S
I
L
L
P
L
M
L
K
--------
S
I
-
G
V
E
A
F
---------
K
G
C
D
F
--------------
K
E
------
I
-----
T
-
I
P
E
G
V
T
--------
V
-----
I
G
D
-
E
-
A
F
A
T
C
-
E
S
L
---
E
Y
V
S
-
L
P
D
S
M-
E
T
L
-------
H
---------
N
---
G
L
F
S
G
C
G
-----
K
L
K
-
S
------------
I
--------
K
L
PRNL
K
-
I
I
R
D
Y
C
F
A
E
C
I
L
L
E
N
M
E
F
P
N
S
L
Y
Y
L
---
G
D
F
A
L
-------
S
KT
G
V
K
N
--
I
--
I
--
I
------
P
D
S
F
---
T
----
E
LGKSVFYGCTDLE
S
I
S
I
Q
N
N
K
L
------------------------
R
I
G
----
G
S
L
F
YN
C
--
S
G
L
K
K
V
I
Y
-
G
S
V
I
V
P
E
K
TFYG
C
-----
S
--
S
-------
L
T
E
---
V
-----
K
L
-------
L
D
S
V
K
F
I
G
E
E
A
--
F
E
S
C
-
T
S
L
V
S
I
D
L
P
YLVEEIGKRS
F
R
G
C
TSLS
N
I
N
F
P
L
S
L
R
K
IGANAF
Q
G
---
C
I
N
L
K
K
V
E
L
P
K
R
L
EQYRYDFEDT
T
K
F
K
W
I
K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.55
22%
-60
- C2 -
2LCK
-
UCP2_MOUSE
A:
[30-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
--
F
P
L
D
T
A
----
K
V
---
R
--
L
Q
I
--
Q
G
ESQG
L
V
R
--------------
T
A
A
S
AQYRG
V
L
G
T
I
L
T
M
-
V
-
R
T
-
E
G
P
----
R
S
L
Y
--
N
G
L
V
A
G
L
-
Q
R
--------
Q
M
-
S
F
A
S
V
---------
R
I
G
L
Y
D
----
S
V
K
Q
F
Y
--
T
K
G
------
S
-----
E
-
H
A
G
I
G
S
R
L
L
A
-
G
--
S
-----
T
T
G
-
A
L
A
V
A
V
A
-
Q
P
T
---
D
V
V
K
V
R
F
Q
A
--
Q
A
R
-------
A
---------
G
GGR
R
Y
Q
S
T
V
E
-----
A
Y
K
-
T
------------
I
A-------
R
E
----
E
-
G
I
R
G
L
W
K
G
T
S
P
N
V
----
A
R
N
A
I
V
N
C
---
A
E
L
V
T
-------
Y
--
D
L
I
K
--
D
--
T
--
L
------
L
K
A
N
---
L
----
M
-------------
T
D
D
L
P
C
H
--------------------------
F
T
S
----
A
F
G
A
--
G
--
F
C
T
T
V
I
A
S
-
P
V
D
V
V
K
T
R
----
Y
-----
M
--
N
-------
S
A
L
---
G
-----
Q
Y
-------
H
S
A
G
H
C
A
L
T
M
L
--
R
K
E
G
-
P
R
A
F
Y
K
-------------
G
F
M
P
----
S
F
L
R
L
G
S
W
N
V
------
V
M
---
F
V
T
Y
E
Q
L
K
R
A
L
M
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
60.42
22%
-48
- C2 -
2LCK
-
UCP2_MOUSE
A:
[15-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
L
G
-
A
--
G
-----
T
A
A
-
C
-
I
A
D
L
I
T
F
P
L
---
D
T
A
K
V
R
L
Q
I
--
Q
G
E
-------
S
QG
L
V
R
T
A
AS
A
---
Q
Y
R
G
V
L
G
-----
T
I
L
-
T
------------
M
V
-------
R
T
----
E
-
G
P
R
S
L
Y
N
G
L
V
A
G
L
----
Q
R
Q
M
S
F
A
S
---
V
R
I
G
L
-------
Y
--
D
S
V
K
--
Q
--
F
--
Y
------
T
K
G
S
--------
E
-------------
H
A
G
I
G
S
R
--------------------------
L
L
A
----
G
S
T
T
--
G
--
A
L
A
V
A
V
A
Q
-
P
T
D
V
V
K
V
R
----
F
-----
Q
--
A
-------
Q
A
R
---
A
GGGR-
R
Y
-------
Q
S
T
V
E
A
Y
K
T
I
A
--
R
E
E
G
---
I
R
G
L
-------------
W
K
G
T
----
S
P
N
V
A
R
N
A
I
V
------
N
C
---
A
E
L
V
T
Y
D
L
I
K
D
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
56.87
15%
-45
- C3 -
1ASH
2
GLB_ASCSU
A:
[1-147]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
K
T
R
E
L
C
M
K
S
L
E
--
H
---------
A
K
V
D
T
S
-------------------------
N
E
A
R
Q
D
G
I
D
L
Y
K
H
M
F
E
N
--
Y
P
P
L
R
K
----
Y
F
---
K
--
S
----
R
E
-----
E
Y
--------------
T
A
E
D
----------
V
Q
N
----
D
-
P
F
F
----
A
K
Q
G
--
Q
K
I
L
L
A
C
-
H
V
--------
L
C
-
A
T
Y
D
D
---------
R
E
T
F
N
A
----
Y
T
R
E
L
L
--
D
R
H
------
A
-----
R
-
D
H
V
H
M
P
P
E
V
W
-
T
--
D
-----
F
W
K
-
L
-
F
E
E
Y
L
-
G
K
K
---
T
T
L
D
E
P
T
K
Q
A
W
H
E
I
-------
G
---------
R
---
E
F
A
K
E
I
N
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.20
26%
-64
- C2 -
2C3E
4
ADT1_BOVIN
A:
[10-145]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
A
G
G
V
A
-
A
--
A
-----
I
S
K
-
T
-
A
V
A
----
P
I
---
E
R
V
K
L
L
L
Q
---
V
Q
H
-------
A
---------
S
---
K
Q
I
S
A
E
K
-----
Q
Y
K
-
G
------------
I
I
D
C
V
V
R
I
P
K
E
----
Q
-
G
F
L
S
F
W
R
G
N
L
A
N
V
----
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
--
D
K
Y
K
--
Q
--
I
--
F
------
L
G
G
V
---
D
----
R
-------------
H
K
Q
F
W
R
Y
--------------------------
F
A
G
N
L
A
S
G
G
A
A
--
G
--
A
T
S
L
C
F
V
Y
-
P
L
D
F
A
R
T
R
----
L
-----
A
--
A
-------
D
V
G
---
K
-----
G
A
-------
A
Q
R
E
F
T
G
L
G
N
C
--
I
T
K
I
-
F
K
S
D
G
L
-------------
R
G
L
Y
----
Q
G
F
N
V
S
V
Q
G
I
------
I
I
---
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
53.62
13%
-69
* C3 *
2HVG
-
?
A:
[21-478]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLKNISPIDGRYKKACGELSAFFS
E
H
A
L
I
K
H
R
I
I
V
E
V
R
W
L
L
F
----
L
N
E
E
E
L
F
F
E
K
V
T
D
--
H
---------
S
V
E
V
L
N
--
Q
I
A
T
N
IT
D
S
D
I
A
R
V
K
A
------
I
E
H
D
V
K
A
V
E
Y
F
V
K
E
K
L
K
N
--
S
K
R
E
D
L
----
L
K
---
I
--
K
E
Y
VH
Y
L
-----
C
T
--------------
S
E
D
I
----------
N
N
V
-
A
-
Y
A
-
T
C
L
----
K
A
C
L
--
N
D
V
V
I
P
C
-
L
E
--------
K
I
M
L
K
L
K
D
---------
L
A
V
E
Y
S
----
H
V
P
L
L
S
--
R
T
H
------
G
-----
Q
-
P
A
S
S
T
T
F
G
K
E
M
A
--
N
-----
F
Y
A
-
R
-
I
H
H
H
V
-
G
V
I
---
R
R
V
K
V
C
A
K
F
--
N
G
A
-------
V
---------
G
---
N
F
N
A
H
K
V
-----
A
S
K
-
D
------------
T
D-------
W
V
----
N
-
T
I
G
L
F
L
K
K
H
F
N
L
T
----
Y
S
I
Y
C
T
Q
I
---
Q
D
H
D
Y
-------
I
--
C
E
L
C
--
D
--
G
--
L
------
A
R
A
N
---
G
----
T
-------------
L
I
D
L
C
V
D
--------------------------
I
W
L
----
Y
I
S
N
--
N
--
L
L
K
L
K
S
S
T
M
P
H
K
V
N
P
I
D
----
F
-----
E
--
N
A
E
G
N
L
H
-
I
A
N
---
A
-----
F
F
-------
K
L
F
S
S
K
L
P
T
S
R
--
L
Q
R
D
-
L
S
D
S
T
V
-------------
L
R
N
I
----
G
S
S
L
A
Y
C
L
I
A
------
Y
K
---
S
V
L
K
G
L
N
K
I
D
I
D
R
R
N
L
E
E
E
L
N
Q
N
WSTL
A
E
P
I
Q
I
V
M
K
R
H
NYVD
A
Y
E
E
L
K
Q
F
T
RGKVID
Q
K
I
M
Q
E
F
I
K
TKCAFLP
Q
D
V
V
D
Q
L
L
E
LTPATYTGY
A
D
Y
L
A
K
N
V
ERLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
52.19
26%
-61
- C2 -
1OKC
7
ADT1_BOVIN
A:
[10-145]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
A
G
G
V
A
-
A
--
A
-----
I
S
K
-
T
-
A
V
A
----
P
I
---
E
R
V
K
L
L
L
Q
---
V
Q
H
-------
A
---------
S
---
K
Q
I
S
A
E
K
-----
Q
Y
K
-
G
------------
I
I
D
C
V
V
R
IP
K
E
----
Q
-
G
F
L
S
F
W
R
G
N
L
A
N
V
----
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
--
D
K
Y
K
--
Q
--
I
--
F
------
L
G
G
V
---
D
----
R
-------------
H
K
Q
F
W
R
Y
--------------------------
F
A
G
N
L
A
S
G
G
A
A
--
G
--
A
T
S
L
C
F
V
Y
-
P
L
D
F
A
R
T
R
----
L
-----
A
--
A
-------
D
V
G
---
K
-----
G
A
-------
A
Q
R
E
F
T
G
L
G
N
C
--
I
T
K
I
-
F
K
S
D
G
L
-------------
R
G
L
Y
----
Q
G
F
N
V
S
V
Q
G
I
------
I
I
---
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
51.77
8%
-67
- C4 -
3GMI
-
Y951_METJA
A:
[1-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q
A
M
L
I
G
E
I
M
D
L
N
----
L
K
N
F
L
E
D
R
E
E
I
I
R
--
D
---------
A
K
R
K
D
E
--
K
S
F
K
D
--------
F
K
K
------
I
V
E
E
I
K
E
R
E
N
K
D
K
I
V
C
D
F
TE
Y
N
P
L
H
K
----
G
H
---
K
--
Y
A
L
--
E
K
-----
G
K
--------------
E
H
G
I
----------
F
I
S
-
V
-
L
P
-
G
P
L
----
E
R
S
G
--
R
G
-
I
P
Y
F
-
L
N
--------
R
Y
-
I
R
A
E
M
---------
A
I
R
A
G
A
----
D
I
V
V
E
G
P
P
M
G
I
------
M
-----
G
-
S
G
Q
Y
M
R
C
L
I
K
-
M
--
F
-----
Y
S
L
-
G
-
A
E
I
I
P
-
R
G
Y
I
P
E
K
T
M
E
K
V
I
D
C
--
I
N
K
-------
G
---------
Y
---
H
I
Q
V
K
P
Y
-----
K
I
I
-
C
IETGEILGEKLN
I
--------
D
N
----
Y
-
V
I
A
S
M
S
Q
M
I
Y
K
L
N
----
R
E
G
L
K
F
N
P
---
K
F
V
F
V
K
R
LEGIS
G
--
T
K
I
R
--
E
--
A
--
I
F
S
GKFE
D
I
K
N
---
M
----
L
-------------
P
K
T
T
L
S
I
--------------------------
L
K
E
----
L
Y
D
N
--
G
--
K
L
N
E
L
I
L
K
-
R
F
E
D
R
I
L
E
----
T
-----
A
--
N
-------
E
Y
D
---
L
-----
Y
E
-------
Y
L
P
S
N
V
A
E
I
L
E
--
K
K
R
P
F
N
N
I
E
E
I
-------------
K
N
S
L
----
P
Y
G
F
S
R
H
F
R
E
------
R
I
---
L
S
K
L
E
A
R
I
P
N
E
T
L
S
K
Y
I
N
N
YPA
K
I
K
I
LAVK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
51.03
33%
-67
- C2 -
3ZLJ
2
MUTS_ECOLI
B:
[490-564]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
R
R
-
Q
T
L
----
K
N
A
E
--
R
Y
I
I
P
E
L
-
K
E
Y
E
D
K
V
L
T
S
K
G
-
K
A
L
A
L
---------
E
K
Q
L
Y
E
----
E
L
F
D
L
L
--
L
P
H
------
L
-----
E
-
A
L
Q
Q
S
A
S
A
L
A
-
E
L
D
V
-----
L
V
N
-
L
-
A
E
R
A
Y
-
T
L
N
---
Y
T
C
P
T
F
I
D
K
--
P
G
I
-------
R
---------
I
---
T
E
G
R
H
P
V
-----
V
E
Q
-
V
------------
L
--------
N
E
----
P
-
F
I
A
N
P
L
N
L
S
P
Q
R
R
----
M
L
I
I
T
G
P
N
---
M
G
G
K
S
-------
T
--
Y
M
R
Q
--
T
--
A
--
L
------
I
A
L
M
---
A
----
Y
-------------
I
G
S
Y
V
P
A
--------------------------
Q
K
V
----
E
I
G
P
--
I
--
D
R
I
F
T
R
V
G
-
A
A
D
D
L
A
S
G
----
R
-----
S
--
T
-------
F
M
V
---
E
-----
M
T
-------
E
T
A
N
I
L
H
N
A
T
E
--
Y
S
L
V
-
L
M
D
E
I
G
-------------
R
G
T
S
----
T
Y
D
G
L
S
L
A
W
A
------
C
A
---
E
N
L
A
N
K
I
K
A
L
T
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------