@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2553_HUMAN: (2015-12-10 )
MGEQNHSPGKELQHRTRAEAPGKKSWHSQAYALGAVSNFMSTFLTFPIYKVVFRQQIHAMAVSEAVRQLWHEGPQYFYRGIYPPLLSKTLQGTLLFGTYDSLLCFLSPVGPHTLGHRWAAGLMSGVVEAVALSPFERVQNVLQDGRKQARFPSTFSILKEFNSYGLWGRLSLGYYRGFWPVLARNSLGSALYFSFKDPIQDGLAEQGLPHWVPALVSGSVNGTITCLVLYPLIVLVANMQSHIGWQNMPSLWASAQDVWNTRGRKLLLIYRGGSLVILRSSVTWGLTTAIHDFLQRKSHSRKELKTD
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.....------...20......---------------..30..---..-....40....--------.-----...50........-------60----------.--------------.--...----..--------..70--------.-......----------.80.....-------...90......-----..--100--..---..------.------...110----...-......120..------.....130--..---------......140.------...---.-.---------.150-...------------------..-...160........170........180.......190.--......200..---...------..210..-.....220........---230-.......-------..240..-----.----....250.------------.....----------.260------...--....270.......-----280.....-----..290....-...300.....--------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGEQNHSP
G
K
E
L
Q
H
R
T
------RAEAPGKKS
W
H
---------------
S
Q
A
Y
A
L
---
G
A
-
V
S
N
F
M
S
T
F
L
T
--------
F
-----
P
I
Y
K
V
V
F
R
Q
Q
I
H
A
-------
M
-----------
A
--------------
V
--
S
E
A
----
V
R
--------
Q
L
W
H--------E-
G
P
Q
Y
F
Y
----------RGIY
P
P
L
L
-------
S
K
TLQ
G
T
L
L
F
G-----
T
Y
--
D
S
---
L
L
---
C
F
------L------SPVG------P
H
T
-
L
G
H
R
W
A
A
G
L
M
S
------
G
V
V
E
A
V
A---LS---------
P
F
E
R
V
Q
N
V
L
Q
------D
G
R
---
K
-Q---------ARF--
P
S
T
------------------
F
S
-
I
L
K
E
F
-NSYGLWGRLS-L
G
Y
YR
G
F
W
P
V
L
A
RNSLG
S
A
L
Y
F
--SFK
D
P
I
Q
D
G
L
A
---EQG------
L
P
H
W
V
P
A
-
L
VSGSVN-G
T
I
T
C
L
V
L
---
Y
---
P
L
I
V
L
V
A
-------
N
M
Q
S
HIG-----W----QN
M
P
S
L
W
A
------------
S
A
Q
D
V
----------
W
NTR------G
R
K
--
L
L
L
I
YRG
G
S
L
V
I
L
R-----SSVTW
G
L
T
-----
T
A
I
H
D
F
L
Q
R
-KSHSRKELKTD--------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
84.95
19%
-69
- C2 -
4ONQ
1
?
A:
[7-353]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPKPMIG
F
G
V
P
T
E
P
L
P
A
M
V
R
R
T
L
------
P
S
Q
A
V
G
P
P
F
F
Y
---------------
Y
E
N
V
A
L
AP
K
G
V
-
W
D
T
I
S
S
S
L
Y
D
--------
I
-----
E
P
E
F
V
D
S
K
Y
-----------
F
-----------
C
--------------
A
--
A
A
R
----
K
R
--------
G
Y
I
H
--------
N
-
L
P
-
V
E
N
----------
R
F
P
L
F
P
L
A
-------
P
R
T
I
H
E
A
L
P
L
S
K
K
W
WP
S
W
--
D
P
RTK
L
N
---
C
L
------
Q
------
T
A
I
G
------
S
A
Q
-
L
T
N
R
I
R
K
A
V
E
D
FDGEPP
M
R
V
Q
K
F
V
---
L
D
---------
Q
C
R
K
W
-
N
L
V
W
------
V
G
R
---
N
-
K
---------
V
A
P
L
E
P
D
E
------------------
V
E
-
M
L
L
G
F
-
P
K
N
H
T
R
G
G
-
G
-
I
S
R
T
D
R
Y
K
S
L
G
N
S
F
Q
V
D
T
V
A
Y
H
L
S
V
L
K
D
L
F
P
G
G
I
N
---
V
L
S
------
L
--------
F
S
G
I
G
G
-
G
E
V
A
L
Y
R
L
G--
I
---
P
L
N
T
V
V
S
-------
V
E
K
S
E
V
N
-----
R
----
D
I
V
R
S
W
W
E
Q
T
NQR
G
N
L
I
H
F
N
D
V
Q
Q
L
----------
N
G
D
R
------
L
E
Q
--
L
I
E
S
F
G
G
F
D
L
V
I
G
G
-----
S
P
S
L
F
S
S
Y
-----
V
R
I
L
D
L
V
K
S
-
I
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
81.89
17%
-74
- C5 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
---------------
L
K
D
F
L
A
---
G
G
-
V
A
A
A
I
S
K
T
A
V
--------
A
-----
P
I
E
R
V
K
L
L
L
Q
V
Q
H
-------
A
SKQISAEKQYK
G
--------------
I
--
I
D
C
----
V
V
--------
R
I
P
K
E-------
Q
-
G
F
L
S
F
W
----------
R
G
N
L
A
N
V
I
-------
R
Y
F
P
T
Q
A
L
N
F
A
-----
F
K
--
D
K
---
Y
K
---
Q
I
------
F
------
L
G
G
V
DRHKQ
F
W
R
Y
-
F
A
G
N
L
A
S
G
G
A
A
------
G
A
T
S
L
C
F
---
V
Y
---------
P
L
D
F
A
R
T
R
L
A
------
A
D
V
---
G
-
K
GAAQ-----
R
E
F
--
T
G
L
------------------
G
N
-
C
I
T
K
I
F
K
S
D
G
L
------
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
--
G
V
Y
D
T
A
K
G
M
L
P
---
D
P
K
------
N
V
H
I
I
V
S
-
W
M
I
A
Q
T
V
-
T
A
V
A
G
L
V
S
---
Y
---
P
F
D
T
V
R
R
-------
R
M
M
M
Q
S
G
-----
R
KGAD
I
M
Y
T
G
T
V
D
------------
C
W
R
K
I
----------
A
K
D
E
------
G
----
P
K
A
F
F
K
G
A
W
S
N
V
L
R
-----
G
M
G
-
G
A
F
V
-----
L
V
L
Y
D
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
77.18
15%
-63
- C5 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
------
D
F
L
A
G
G
V
A
A
A
I
---------------
S
K
T
A
V
-----
A
-
P
I
E
R
V
K
L
L
L
Q
--------
V
-----
Q
H
A
S
K
Q
I
S
A
E
K
Q
Y
-------
K
-----------
G
--------------
I
--
I
D
C
----
V
V
--------
R
I
P
K
--------
E
Q
G
F
L
S
F
W
----------
R
G
N
L
A
N
V
I
-------
R
Y
F
P
T
Q
A
L
N
F
A
-----
F
K
--
D
K
---
Y
K
---
Q
I
------
F
L
GGVDR
H
K
Q
F
------
W
R
Y
-
F
A
G
N
L
A
S
G
G
A
A
------
G
A
T
S
L
C
F
---
V
Y
---------
P
L
D
F
A
R
T
R
L
A
------
A
D
V
---
G
-
K
---------
G
A
A
--
Q
R
E
------------------
F
T
-
G
L
G
N
C
-
I
T
K
I
F
K
S
D
G
L
-
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
--
G
V
Y
D
T
A
K
G
M
L
P
---
D
P
K
------
N
V
H
I
I
V
S
-
W
M
I
A
Q
T
V
-
T
A
V
A
G
L
V
S
---
Y
---
P
F
D
T
V
R
R
-------
R
M
M
M
Q
S
G
-----
R
----
K
G
A
D
I
M
Y
T
------------
G
T
V
D
C
----------
W
R
K
I
------
A
K
D
EG
P
K
A
F
F
K
G
A
W
S
N
V
L
R
-----
G
M
G
G
A
F
V
L
-----
V
L
Y
D
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
74.55
16%
-77
- C4 -
3AQL
1
?
A:
[1-411]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVTV
I
P
R
E
Q
H
A
I
S
R
K
D
I
S
E
N
A
L
K
V
M
Y
R
L
N
K
A
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
GKKPK
D
F
D
V
T
T
---
N
A
-
T
P
E
Q
V
R
K
L
F
R
NCR
L
V
G
R
R
F
-----
R
L
A
H
V
M
F
G
P
E
I
I
E
-------
V
-----------
A
--------------
T
--
F
R
G
NIFG
S
I
--------
E
E
D
A
--------
Q
-
R
R
D
F
T
I
----------
N
S
L
Y
Y
S
V
A
-------
D
F
T
V
R
-
D
Y
V
G
G
-----
M
K
--
D
L
---
K
D
---
G
V
------
I
------
R
L
I
G
N-----
P
E
T
-
R
Y
R
E
D
P
V
R
M
L
R
------
A
V
R
F
A
A
K
---
L
G
MRISPETAE
P
I
P
R
L
A
T
L
L
N
------
D
I
P
---
P
-
A
---------
H
L
F
--
E
E
S
------------------
L
K
-
L
L
Q
A
G
-
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
F
P
T
I
T
R
Y
F
T
E
N
--------
G
D
S
P
M
E
R
I
I
---
E
Q
V
------
L
K
N
T
D
T
R
-
I
H
N
D
M
R
V
-
N
P
A
F
L
F
A
A
M
F
W
Y
---
P
L
L
E
T
A
Q
-------
K
I
A
Q
E
S
G
-----
L
----
T
Y
H
D
A
F
A
L
------------
A
M
N
D
V
----------
L
D
E
A
C
R
S
LAI
P
K
R
--
L
T
T
L
T
R
D
I
W
Q
L
Q
L
R
M
S
RRQ
G
K
R
A
W
K
L
L
E
HPK
F
R
A
A
Y
D
L
L
A
L
-
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
SA
P
P
D
Q
K
G
M
L-----------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
73.57
21%
-65
- C5 -
2LCK
-
UCP2_MOUSE
A:
[14-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
K
F
L
G
---
A
G
-
T
A
A
C
I
A
D
L
I
T
--------
F
-----
P
L
D
T
A
K
V
R
L
Q
I
Q
G
-------
E
-----------
S
QG
L
V
R
T
A
ASAQYRG
V
--
L
G
T
----
I
L
--------
T
M
V
R
T
-------
E
-
G
P
R
S
L
Y
----------
N
G
L
V
A
G
L
Q
-------
R
Q
M
S
F
A
S
V
R
I
G
-----
L
Y
--
D
S
---
V
K
---
Q
F
------
Y
------
T
K
G
S
E-----
H
A
G
-
I
G
S
R
L
L
A
G
S
T
T
------
G
A
L
A
V
A
V
---
A
Q
---------
P
T
D
V
V
K
V
R
F
Q
------
A
Q
A
---
R
-
A
GGG------
R
R
Y
--
Q
S
T
------------------
V
E
-
A
Y
K
T
I
A
R
E
E
G
I
------
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
--
V
T
Y
D
L
I
K
D
T
L
L
---
K
A
N
LM----
T
D
D
L
P
C
H
-
F
T
S
A
F
G
A
-
G
F
C
T
T
V
I
A
---
S
---
P
V
D
V
V
K
T
-------
R
Y
M
N
S
A
L
-----
G
-----
Q
Y
H
S
A
G
H
------------
C
A
L
T
M
----------
L
R
K
E
------
G
----
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
-----
L
G
S
W
N
V
V
M
-----
F
V
T
Y
E
Q
L
K
R
-
A
L
M
A
A
Y
Q
S
R
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
71.57
19%
-72
- C5 -
1OKC
8
ADT1_BOVIN
A:
[5-204]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
-
F
L
K
D
F
L
A
G
G
V
A
------
A
A
I
S
K
T
A
---
V
A
---------
P
I
E
R
V
K
L
L
L
Q
------
V
Q
H
---
A
-
S
KQISAE---
K
Q
Y
--
K
G
I
------------------
I
D
-
C
V
V
R
I
P
K
E
Q
G
F
------
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
--
A
F
K
D
K
Y
K
Q
I
F
L
---
G
G
V
DRHKQ
F
W
R
Y
F
A
G
N
-
L
A
S
G
G
A
A
-
G
A
T
S
L
C
F
V
---
Y
---
P
L
D
F
A
R
T
-------
R
L
A
A
D
V
G
-----
K
GAAQ
R
E
F
T
G
L
G
N
------------
C
I
T
K
I
----------
F
K
S
D
------
G
----
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
-----
I
I
I
Y
R
A
A
Y
-----
F
G
V
Y
D
T
A
K
G
-
M
L
P
D
P
K
N
V
H
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
62.23
16%
-58
- C4 -
4HNE
1
P4K2A_HUMAN
A:
[2-384]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
G
S
P
E
F
A
A
Q
A
Q
A
------
L
A
A
Q
A
A
A
A
A
H
A
---------------
A
Q
A
H
R
E
---
R
-------
N
E
F
P
E
--------
D
-----
P
E
F
E
A
V
V
R
Q
A
E
L
A
-------
I
-----------
E
--------------
R
--
C
I
F
----
P
E
--------
R
I
Y
Q
GSSG
S
Y
F
V
K
-
D
P
Q
G
R
I
----------
I
A
V
F
K
P
K
N
EEPYGHL
N
P
K
W
T
K
W
L
Q
K
F
-----
G
R
--
D
C
---
L
V
LNQ
G
Y
------
L
------
S
E
A
G
------
A
S
L
-
V
D
Q
K
L
E
L
N
I
V
P
------
R
T
K
V
V
Y
L
---
A
S
---------
E
T
F
N
Y
S
A
I
D
R
------
V
K
S
---
R
-
G
---------
K
R
L
--
A
L
R
------------------
F
N
-
R
I
G
L
P
-
P
K
V
G
S
F
Q
L
F
V
-
E
G
Y
K
D
------
A
D
Y
W
L
R
R
F
E
A
E
--
P
L
P
E
N
T
N
R
Q
L
L
---
L
Q
F
------
E
R
L
V
V
L
D
-
Y
I
I
R
N
T
D
R
G
N
D
N
W
L
I
K
---
Y
D
C
P
P
V
I
K
V
A
A
IDNGLAF
P
L
K
H
P
D
S
-----
W
----
R
A
Y
P
F
Y
W
A
WLP---------
Q
A
K
V
P
----------
F
S
Q
E
------
I
K
D
--
L
I
L
P
K
I
S
D
-----------
P
N
F
V
K
D
L
E
-----
E
D
L
Y
E
L
F
K
K
D
P
G
F
D
R
G
Q
F
H
K
Q
I
A
V
M
R
G
Q
I
L
N
L
T
Q
A
L
K
D
NKS
P
L
H
L
V
Q
M
P
P
V
I
V
E
T----------------------------------------------------------------------------------------------------------------------
34
Fugue
60.67
12%
-65
- C3 -
3ODN
-
?
A:
[117-614]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TC
C
T
Y
N
M
E
T
R
M
A
M
Q
S
R
Q
Q
------
L
E
G
H
T
K
D
Q
I
S
R
---------------
M
S
G
I
L
G
---
S
K
-
A
T
K
F
K
D
I
F
T
A
--------
L
L
K
E
S
R
T
Q
F
N
S
M
F
I
R
T
Y
G
V
-------
I
-----------
Y
--------------
E
R
N
S
Y
V
----
F
S
--------
D
L
F
K
--------
E
-
L
E
T
Y
F
A
NGRVD
L
L
E
V
M
D
K
F
F
N
T
L
Y
-------
Q
K
M
F
T
V
L
N
T
Q
Y
-----
T
F
D
E
N
Y
---
M
R
---
C
V
S
E
H
M
KE
L
------
K
P
F
G
D
V
----
P
D
K
-
L
S
V
Q
I
K
R
S
F
V
A
------
T
R
T
Y
G
Q
A
---
L
T
---------
T
A
S
E
V
A
K
K
V
L
------
N
A
D
---
C
-
T
---------
G
A
L
--
T
K
M
Q
H
C
G
A
C
K
GYTEKPC
T
N
Y
C
V
N
-
V
I
K
G
C
-
L
H
Y
Q
H
E
F
D
S
E
-
W
E
N
F
A
M
A
M
D
K
V
A
E
R
L
L
G
S
F
N
I
V
--
M
V
V
E
P
L
N
I
K
I
S
---
E
-
A
------
I
M
N
F
Q
D
S
-
G
Q
D
I
T
N
R
-
V
F
Q
G
C
G
R
E
---
P
---
I
L
D
R
I
V
R
-------
D
I
R
Q
R
V
K
D
Y
KKF
W
----
S
N
L
P
H
S
V
C
------------
S
N
E
D
I
ASSSDVDGMC
W
N
G
H
------
T
I
D
--
R
---
Y
M
H
S
I
T
T
E
S
N
-----
P
E
F
M
A
S
Q
L
-----
S
H
L
K
N
A
I
V
H
-
L
R
N
A
Y
N
G
Q
D
V
E
W-------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
59.19
31%
-60
- C5 -
4C9G
4
ADT2_YEAST
A:
[28-148]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
------
G
V
S
A
A
V
A
K
T
A
A
S
---------
P
I
E
R
V
K
L
L
I
Q
------
N
Q
D
E
M
L
K
-
Q
---------
G
T
L
--
D
R
K
------------------
Y
A
G
I
L
D
C
F
-
K
R
T
A
T
Q
E
G
V
--
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
--
A
F
K
D
K
I
K
A
M
F
G
FKK
E
E
G
------
Y
A
K
W
F
A
G
N
L
A
S
G
G
A
A
-
G
A
L
S
L
L
F
V
---
Y
---
S
L
D
Y
A
R
T
-------
R
L
A
A
D
S
R
-----
Q
----
F
N
G
L
I
D
V
Y
------------
K
K
T
L
K
----------
S
D
G
V
------
A
G
L
--
Y
R
G
F
L
P
S
V
V
G
I
V
V
Y
-----
R
G
L
Y
F
G
M
Y
-----
D
S
L
L
A
S
F
L
L
-
G
W
V
V
T
T
G
A
S
T
C
--------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
58.69
31%
-58
- C5 -
4C9H
4
ADT2_YEAST
A:
[28-148]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
------
G
V
S
A
A
V
A
K
T
A
A
S
---------
P
I
E
R
V
K
L
L
I
Q
------
N
Q
D
E
M
L
K
-
Q
---------
G
T
L
--
D
R
K
------------------
Y
A
G
I
L
D
C
F
-
K
R
T
A
T
Q
E
G
V
--
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
--
A
F
K
D
K
I
K
A
M
F
G
F
K
K
E
E
G
------
Y
A
K
W
F
A
G
N
L
A
S
G
G
A
A
-
G
A
L
S
L
L
F
V
---
Y
---
S
L
D
Y
A
R
T
-------
R
L
A
A
D
S
A
-----
R
----
Q
F
N
G
L
I
D
V
------------
Y
K
K
T
L
----------
K
S
D
G
------
V
A
G
--
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
-----
Y
R
G
L
Y
F
G
M
-----
Y
D
S
L
K
L
A
S
F
-
L
L
G
W
V
V
T
T
G
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_CBE
58.63
31%
-57
- C5 -
4C9J
5
ADT3_YEAST
B:
[32-152]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
------
G
V
S
A
A
I
A
K
T
A
A
S
---------
P
I
E
R
V
K
I
L
I
Q
------
N
Q
D
E
M
I
K
-
Q
---------
G
T
L
--
D
K
K
------------------
Y
S
G
I
V
D
C
F
-
K
R
T
A
K
Q
E
G
L
--
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
--
A
F
K
D
K
I
K
L
M
F
G
---------------
W
F
A
G
N
L
A
S
G
G
A
A
-
G
A
L
S
L
L
F
V
---
Y
---
S
L
D
F
A
R
T
-------
R
L
A
A
D
A
K
-----
S
----
S
A
R
Q
F
N
G
L
------------
T
D
V
Y
K
----------
K
T
L
K
------
S
D
G
--
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
-----
I
V
V
Y
R
G
L
Y
-----
F
G
M
F
D
S
L
F
L
-
L
G
W
V
V
T
T
G
A
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_CBE
57.68
31%
-59
- C5 -
4C9Q
3
ADT3_YEAST
B:
[32-152]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
------
G
V
S
A
A
I
A
K
T
A
A
S
---------
P
I
E
R
V
K
I
L
I
Q
------
N
Q
D
E
M
I
K
-
Q
---------
G
T
L
--
D
K
K
------------------
Y
S
G
I
V
D
C
F
-
K
R
T
A
K
Q
E
G
L
--
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
--
A
F
K
D
K
I
K
L
M
F
G
FKK
E
E
G
------
Y
G
K
W
F
A
G
N
L
A
S
G
G
A
A
-
G
A
L
S
L
L
F
V
---
Y
---
S
L
D
F
A
R
T
-------
R
L
A
A
D
A
A
-----
R
----
Q
F
N
G
L
T
D
V
------------
Y
K
K
T
L
----------
K
S
D
G
------
I
A
G
--
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
-----
Y
R
G
L
Y
F
G
M
-----
F
D
S
L
K
P
L
V
S
-
F
L
A
S
F
L
L
G
W
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.25
23%
-88
- C5 -
1UJB
-
SIXA_ECOLI
A:
[45-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
V
L
---
V
S
---------
P
F
L
R
A
E
Q
T
L
E
------
E
V
G
---
D
-
C
---------
L
N
L
--
P
S
S
------------------
A
E
-
V
L
P
E
L
-
T
P
C
G
-----
D
-
V
G
L
V
S
A
Y
L
Q
A
L
T
N
E
G
V
A
S
V
L
V
I
--
S
H
L
-
P
L
V
G
Y
L
V
---
A
E
L
------
C
P
G
E
T
P
P
-
M
F
T
T
S
A
I
-
A
S
V
T
L
D
E
S
---
G
---
N
G
T
F
N
W
Q
-------
M
S
P
C
N
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_CBE
56.49
31%
-58
- C5 -
4C9H
5
ADT2_YEAST
B:
[28-148]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
------
G
V
S
A
A
V
A
K
T
A
A
S
---------
P
I
E
R
V
K
L
L
I
Q
------
N
Q
D
E
M
L
K
-
Q
---------
G
T
L
--
D
R
K
------------------
Y
A
G
I
L
D
C
F
-
K
R
T
A
T
Q
E
G
V
--
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
--
A
F
K
D
K
I
K
A
M
F
G
F
K
K
E
E
G
------
Y
A
K
W
F
A
G
N
L
A
S
G
G
A
A
-
G
A
L
S
L
L
F
V
---
Y
---
S
L
D
Y
A
R
T
-------
R
L
A
A
D
S
K
-----
G
----
A
R
Q
F
N
G
L
I
------------
D
V
Y
K
K
----------
T
L
K
S
------
D
G
V
--
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
-----
V
V
Y
R
G
L
Y
F
-----
G
M
Y
D
S
L
K
L
A
-
S
F
L
L
G
W
V
V
T
T
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
56.33
23%
-92
- C5 -
1UJC
-
SIXA_ECOLI
A:
[45-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
V
L
---
V
S
---------
P
F
L
R
A
E
Q
T
L
E
------
E
V
G
---
D
-
C
---------
L
N
L
--
P
S
S
------------------
A
E
-
V
L
P
E
L
-
T
P
C
G
-----
D
-
V
G
L
V
S
A
Y
L
Q
A
L
T
N
E
G
V
A
S
V
L
V
I
--
S
H
L
-
P
L
V
G
Y
L
V
---
A
E
L
------
C
P
G
E
T
P
P
-
M
F
T
T
S
A
I
-
A
S
V
T
L
D
E
S
---
G
---
N
G
T
F
N
W
Q
-------
M
S
P
C
N
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.06
31%
-57
- C5 -
4C9Q
3
ADT3_YEAST
A:
[32-152]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
------
G
V
S
A
A
I
A
K
T
A
A
S
---------
P
I
E
R
V
K
I
L
I
Q
------
N
Q
D
E
M
I
K
-
Q
---------
G
T
L
--
D
K
K
------------------
Y
S
G
I
V
D
C
F
-
K
R
T
A
K
Q
E
G
L
--
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
--
A
F
K
D
K
I
K
L
M
F
G
FKK
E
-
G
------
Y
G
K
W
F
A
G
N
L
A
S
G
G
A
A
-
G
A
L
S
L
L
F
V
---
Y
---
S
L
D
F
A
R
T
-------
R
L
A
A
D
A
K
-----
S
----
A
R
Q
F
N
G
L
T
------------
D
V
Y
K
K
----------
T
L
K
S
------
D
G
I
--
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
-----
V
V
Y
R
G
L
Y
F
-----
G
M
F
D
S
L
K
P
L
-
F
L
A
S
F
L
L
G
W
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
55.43
12%
-47
* C4 *
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSKLGIL
L
P
S
L
L
N
S
L
P
R
F
L
D
D
GK
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
APKLFKDM
F
D
Q
I
I
Q
F
T
D
M
V
I
K
NKDLEP
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
EVSIDDDDA
A
E
W
I
E
SDDTDDEEE
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
LGGEYL
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
STE
W
R
E
R
F
A
A
M
M
A
L
S
S
A
AEGCA
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
NDPH
P
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
TSECT
S
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
FASKDILEPY
L
D
S
L
L
T
N
L
L
V
L
L
Q
SNK
L
Y
V
Q
E
Q
A
L
T
T
I
A
F
I
A
E
A
A
KNKFIKYYDTL
M
P
L
L
L
N
V
L
K
VN
S
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
K
E
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
SD
A
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
GDDFVPLLPIVI
P
P
L
L
I
T
A
K
A
T
Q
D
V
G
L
I
-------------
E
E
E
E
A
A
N
---------------
F
Q
Q
Y
P
D
---
W
D
-
V
V
Q
V
Q
G
K
--
H
--------
I
-----
A
I
H
T
S
V
L
D
D
K
V
S
A
-------
M
-----------
E
--------------
L
--
L
Q
S
----
Y
A
--------
T
L
L
R
--------
G
-
Q
F
A
V
Y
V
----------
K
E
V
M
E
E
I
A
-------
L
P
S
L
D
----
F
Y
-----
L
H
--
D
G
---
V
R
---
A
A
------
G
------
A
T
L
I
------
P
I
L
-
L
S
C
L
L
A
A
E
E
L
V
------
L
L
W
H
K
A
S
---
S
K
---------
L
I
G
G
L
M
S
E
P
M
------
P
E
I
---
T
-
Q
---------
V
Y
H
--
N
S
L
------------------
V
N
-
G
I
K
V
M
-
G
D
----
N
C
L
S
-
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
--
Q
D
R
D
E
Y
N
E
D
F
T
---
D
E
D
------
L
L
D
E
I
N
K
-
S
I
A
A
V
L
K
-
T
T
-----------------------------
N
G
H
Y
------
L
----
K
N
L
E
N
I
W
P
------------
M
I
N
T
F
----------
L
L
E
P
------
I
L
V
--
I
F
A
L
V
V
I
G
D
L
I
--
Q
-----
Y
E
Q
T
A
S
M
K
-----
N
A
F
I
P
K
V
T
E
-
C
L
I
S
P
D
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
YAPSTYADVCIPT
L
D
T
L
V
Q
I
V
DGSKLEEN
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
NSNIPD
T
Y
T
A
N
W
F
K
T
LPTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
4
PsiBlast_PDB
55.03
31%
-61
- C5 -
4C9J
4
ADT3_YEAST
A:
[32-152]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
------
G
V
S
A
A
I
A
K
T
A
A
S
---------
P
I
E
R
V
K
I
L
I
Q
------
N
Q
D
E
M
I
K
-
Q
---------
G
T
L
--
D
K
K
------------------
Y
S
G
I
V
D
C
F
-
K
R
T
A
K
Q
E
G
L
--
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
--
A
F
K
D
K
I
K
L
M
F
G
FKK
E
E
G
------
Y
G
K
W
F
A
G
N
L
A
S
G
G
A
A
-
G
A
L
S
L
L
F
V
---
Y
---
S
L
D
F
A
R
T
-------
R
L
A
A
D
A
K
-----
S
----
A
R
Q
F
N
G
L
T
------------
D
V
Y
K
K
----------
T
L
K
S
------
D
G
I
--
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
-----
V
V
Y
R
G
L
Y
F
-----
G
M
F
D
S
L
K
F
L
-
L
G
W
V
V
T
T
G
A
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
53.26
25%
-40
- C5 -
2LCK
-
UCP2_MOUSE
A:
[18-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
A
G
T
A
A
C
I
A
D
L
I
T
--------
F
-----
P
L
D
T
A
K
V
R
L
Q
I
Q
G
ESQG
L
V
R
T
-----------
A
--------------
A
--
S
A
Q
----
Y
R
G
V
L
G
T
I
L
T
M
V
R
T
--------
E
-
G
P
R
S
L
Y
----------
N
G
L
V
A
G
L
Q
-------
R
Q
M
S
F
A
S
V
R
I
G
-----
L
Y
--
D
S
---
V
K
---
Q
F
------
Y
------
T
K
G
S
------
E
H
A
G
I
G
S
R
L
L
A
G
S
T
T
------
G
A
L
A
V
A
V
---
A
Q
---------
P
T
D
V
V
K
V
R
F
Q
A
QARAG
G
G
R
---
R
Y
Q
---------
S
T
V
--
E
A
Y
------------------
K
T
-
I
A
R
E
E
-
G
I
R
G
L
W
---------
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
--
V
T
Y
D
L
I
K
D
T
L
L
---
K
A
N
------
L
M
T
D
D
L
P
-
C
H
F
T
S
A
F
-
G
A
G
F
C
T
T
V
---
I
---
A
S
P
V
D
V
V
-------
K
T
R
Y
M
N
S
-----
A
----
L
G
Q
Y
H
S
A
G
------------
H
C
A
L
T
----------
M
L
R
K
------
E
G
P
--
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
-----
G
S
W
N
V
V
M
F
-----
V
T
Y
E
Q
L
K
R
A
-
L
M
A
A
Y
Q
S
R
E
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
50.19
13%
-59
- C5 -
2LCK
-
UCP2_MOUSE
A:
[15-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
L
G
A
G
T
A
------
A
C
I
A
D
L
I
---
T
F
---------
P
L
D
T
A
K
V
R
L
Q
------
I
Q
G
---
E
-
S
QG
L
V
R
T
A
AS
A
Q
Y
--
R
G
V
------------------
L
G
-
T
I
L
T
M
V
R
T
E
G
P
------
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
A
S
V
R
I
--
G
L
Y
D
S
V
K
Q
F
Y
T
---
K
G
S
E-----
H
A
G
I
G
S
R
-
L
L
A
G
S
T
T
-
G
A
L
A
V
A
V
A
---
Q
---
P
T
D
V
V
K
V
-------
R
F
Q
A
Q
A
R
-----
A
GGG-
R
R
Y
Q
S
T
V
E
------------
A
Y
K
T
I
----------
A
R
E
E
------
G
----
I
R
G
L
W
K
G
T
S
P
N
V
A
R
-----
N
A
I
V
N
C
A
E
-----
L
V
T
Y
D
L
I
K
D
-
T
L
L
K
A
N
L
M
T
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------