@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S26A1_HUMAN: (2015-12-10 )
MDESPEPLQQGRGPVPVRRQRPAPRGLREMLKARLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSSTLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAARRKEGGSETGVGEGGPAQGEDLGPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARARHRELEATDAHL
Atome Classification :
(20 SA)
--------------.........10........20---........--30--------........40........-----50........60.....---...70---......--------.------.80...--.....90........100.......110-...-....120.......130.......140....--...150.......160......----.170.......180...---....190......----.200........210.......220.......------230.--......240.......250.......260.......270....--------...280...----------....290.......300.......310--------------------.....-..320..-.-.---...330.-..---....340...-....350-.....--------...360.-------.....----.370.......380.......390-........400.......410.......420.......--430-....-...440...----..-------..450......---------------------.460.......----470.......480.-----------......490.......500.......510..-.....520.......530....---...540...---.....550.......--560.....-..570.....--.--.580.---------...---...590...-.--.--..600.---......610.......620-....-------...630-.....-.-.-640.-.......650.......660.------......670...-....680.......690.......--700
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MDESP
E
P
L
Q
QGRGPVPVRRQR---PA
P
R
G
L
R
E
--
M
L
--------
K
A
R
LWCSC
S
C
S
V
L
C
V
R
A
L
-----
V
Q
D
L
L
P
A
T
R
W
L
R
QYR
P
R
---
E
Y
L
A
G
---
D
V
M
S
G
L
--------
V
------
I
G
I
I
LV--
P
Q
A
I
A
Y
S
L
L
A
G
L
Q
P
I
Y
S
L
Y
T
S
F
F
A
N
L
I
Y
-
F
L
M-GTSRH
V
S
V
G
I
F
S
L
L
C
L
M
V
G
Q
V
V
D
R
E
L
QLAGF--DPSQDGLQPGANSSTLNG
S
A
A
M
----
L
DCGR
D
C
Y
A
I
R
V
A
T
A
L
T
---
L
M
T
G
L
Y
Q
V
L
M
G
V
L
----
R
L
-
G
F
V
S
A
Y
LS
Q
P
L
L
D
G
FAMGA
S
V
T
I
L
T
S
Q
L
K
------
H
L
LG--VRIPRHQGPG
M
V
V
L
T
W
L
S
L
L
RGAGQ
A
N
V
C
D
V
V
T
S
T
V
C
L
A
V
L
L
A
--------
A
K
E
L
S
D
R
Y
R
----------
H
RLRVPL
P
T
E
L
L
V
I
V
V
A
T
L
V
S
H
F
G
Q
L
H
--------------------
K
R
FG
S
-
S
VAGDIP-T-G---FMPPQVP-
E
P
---
R
L
M
Q
R
V
A
L
D
A
-
V
A
L
A
L
V
--
A
A
A
F
S
--------
I
S
L
A
E
M
F
-------
A
R
SHG----
Y
S
VRANQ
E
L
L
A
V
G
C
C
N
V
L
P
A
F
L
H
--
C
FA
T
S
A
A
L
A
K
S
L
V
K
T
ATG
C
R
T
Q
L
S
S
V
V
S
A
T
V
V
L
L
V
L
L
A
--
L
A
P
-
L
F
H
D
-
L
Q
R
S
V
L
A
C
V
----
I
V
-------
V
S
L
R
G
A
L
R
K
V
W---------------------D
L
P
R
L
WRMSPA----D
A
L
V
WAGT
A
A
T
C
M
L
-----------
V
STE
A
G
L
L
A
G
V
I
L
S
L
L
S
LAGRTQR
P
R
T
A
L
L
A
-RIGDTAFYE
D
A
T
E
FEGLVPEPG---
V
R
V
F
R
-FGG---
P
L
Y
YA
N
K
D
F
F
L
Q
S
L
Y
--
S
L
TGL
D
A
G
-
C
M
A
A
R
RKEGG--S--ETGVG---------EGG---PAQGEDLGP-V--S--TR
A
A
LV---PAAAG
F
H
T
V
V
IDCA
P
L
L
F
L-DAA
G
-------
V
S
T
L
Q
D
-
L
R
R
D
Y
-
G
-
A
-
L
G
-
I
-
S
L
L
L
A
CCSP
P
V
R
D
I
L
S
RGGFL------GEGPGDT
A
E
E
E
Q
-
L
F
L
S
V
H
D
A
V
Q
T
A
R
A
R
HRELEATDA--HL
24
Fugue
86.24
19%
-95
- C2 -
4UI9
-
APC5_HUMAN
O:
[27-756]
KDWVTPYKIAVLVL
L
S
E
M
S
---
R
T
G
E
G
A
V
S
L
V
E
R
R
---
R
L
N
Q
Q
L
L
P
--
L
L
QGPDITVS
K
L
L
K
L
I
E
E
S
C
P
Q
L
A
N
S
V
Q
-----
I
R
I
K
L
M
A
E
G
E
L
K
D
M
E
Q
F
---
F
D
D
L
S
---
D
S
F
S
G
T
EPEVHKTS
V
------
V
G
L
F
L
R
--
H
M
I
L
A
Y
S
K
L
-
S
F
S
Q
V
F
K
L
Y
T
A
L
Q
Q
---
Y
-
F
Q
S
-
D
E
N
K
K
------
P
L
S
Q
K
Q
A
E
F
F
L
S
Q
Q
A
S
L
L
K
N
--
D
E
T
K
-
A
L
T
P
A
S
L
Q
K
E
L
N
N
L
L
K
F
----
N
P
D
F
A
E
A
H
Y
L
S
Y
L
N
N
L
R
VQD
V
F
S
S
T
H
S
L
L
H
Y
F
D
----
R
L
-
I
L
T
G
A
E
S
K
S
N
G
E
E
G
Y
G
-----
R
S
L
R
Y
A
A
L
------
N
L
A
A
--
L
H
C
-
R
F
G
H
Y
Q
Q
A
E
L
A
L
Q
E
A
I
R
I
A
Q
E
S
N
--
D
H
V
C
L
Q
H
C
L
S
W
L
Y
V
LGQKRSDS
Y
V
L
L
E
H
S
V
K
----------
K
A
V
H
F
G
L
P
Y
-
L
A
S
L
G
I
Q
S
L
V
Q
Q
R
A
F
A
G
--------------------
K
T
A
N
K
-
L
M
D
A
L
K
D
-
S
-
D
---
L
L
H
W
K
H
S
-
L
S
---
E
L
I
D
I
S
I
A
Q
K
-
T
A
I
W
R
L
YG
R
S
T
M
A
--------
L
Q
Q
A
Q
M
L
-------
L
S
M
N
S
----
L
E
Q
Q
N
N
T
E
S
F
A
V
A
L
C
H
L
A
E
L
H
A
E
QG
C
F
A
A
A
S
E
V
L
K
H
L
K
E
R
F
P
P
N
S
Q
H
A
Q
L
W
M
L
C
D
Q
K
I
Q
F
D
R
A
--
M
N
D
G
K
Y
H
L
-
A
D
S
L
V
T
G
I
T
----
A
L
-------
N
S
I
E
G
V
Y
R
K
A
V
---------------------
V
L
Q
A
Q
N
Q
M
S
E
A
----
H
K
L
L
Q
K
L
L
V
H
C
Q
K
L
-----------
K
N
T
E
--
M
V
I
S
V
L
L
S
V
A
E
L
Y
W
R
S
S
S
P
T
I
A
L
P
M
-
L
L
Q
A
L
A
L
S
K
E
Y
R
--------------------------
L
Q
Y
L
A
S
E
T
V
L
N
L
A
F
--
A
Q
L
I
L
----------------------------------
G
I
---
P
E
Q
A
L
S
L
L
H
-
M
--
A
--
I
E
P
I
L
A
---
D
G
A
I
L
D
K
G
R
A
M
F
L
V
A
K
C
Q
V
-
A
S
A
A
SYDQPKK
A
E
A
L
E
A
-
A
I
E
N
L
-
N
-
E
-
A
K
-
N
-
Y
F
A
K
V
D
C
K
E
R
I
R
D
V
V
Y
F
Q
A
R
L
------
Y
H
T
L
G
K
T
Q
E
R
N
R
-
C
A
M
L
F
R
Q
L
-------
H
Q
E
L
P
S
V
P
L
IN
H
L
21
Fugue
78.39
17%
-86
* C2 *
4J5T
4
CWH41_YEAST
A:
[1-811]
-----------A
E
F
M
E
E
Y
Q
K
F
T
N
E
S
L
L
W
A
P
Y
R
S
N
C
Y
F
G
M
R
P
R
Y
V
H
E
SP
L
I
--------
M
G
I
M
W
F
N
-
S
L
S
Q
D
G
L
H
S
L
RHFAT
P
Q
D
K
L
Q
K
Y
G
W
-
E
V
Y
D
P
R
I
G
G
K
E
V
F
I
---
D
E
K
N
N
L
--------
N
------
L
T
V
Y
F
V
K
S
K
N
G
E
N
W
S
V
R
V
Q
G
E
P
L
D
P
K
R
P
S
T
A
S
V
V
L
Y
-
F
S
Q
-
N
G
G
E
I
D
G
K
S
S
L
A
M
I
----
G
H
D
G
P
N
D
M
K
F
F
G
Y
S
K
E
L
G
E
Y
H
L
T
V
K
D
N
F
G
H
Y
F
K
N
P
E
Y
ETME
V
A
P
G
S
D
C
---
S
K
T
S
H
L
S
---
L
Q
I
P
D
K
E
V
W
K
A
R
D
----
V
F
Q
S
L
V
S
D
S
I
R
D
I
L
E
R
P
A
D
L
I
P
S
V
L
T
I
R
N
L
Y
N
FNPGN
F
H
Y
I
Q
--
K
T
F
D
L
T
K
K
D
G
F
Q
F
D
I
T
Y
N
K
L
G
T
T
Q
S
I
S
T
R
E
Q
V
T
E
L
I
T
W
S
L
N
E
I
--------
N
A
R
F
D
K
Q
F
S
F
G
EGPDSIES
V
E
V
K
R
R
F
A
L
E
T
L
S
N
L
L
G
G
I
G
Y
F
Y
G
N
Q
L
I
D
RETEFDESQFTEIKLLN
A
K
E
E
G
P
F
E
L
F
T
S
V
P
-
S
R
G
---
F
F
P
R
G
F
Y
-
W
D
E
G
F
H
L
L
Q
I
M
E
Y
D
F
D
L
A
F
E
I
L
--
A
S
W
F
E
M
IEDDSGW
I
A
R
E
I
I
L
-------
G
N
E
A
R
----
S
K
V
P
Q
E
F
Q
V
Q
N
P
N
I
A
N
P
-
P
T
L
L
L
--
A
F
S
E
M
L
S
R
A
I
E
N
I
G
D
F
M
T
N
N
L
E
A
N
P
G
L
L
T
E
Y
A
K
K
I
Y
P
K
--
L
L
K
-
H
Y
N
W
-
F
R
K
S
Q
T
G
L
I
DEY
E
E
I
-------
L
E
D
E
G
I
W
D
K
I
H
KNEVYRWVGRTFTHCLPSGMD
D
Y
P
R
A
Q
P
P
D
V
A
ELN
V
D
A
L
A
W
V
G
V
M
T
R
S
M
K
-----------
Q
I
A
H
V
-------
L
K
L
T
Q
D
E
Q
R
Y
A
Q
I
E
Q
E
V
V
E
-
N
L
D
L
L
H
W
S
E
N
D
N
C
Y
C
D
I
S
I
D
P
E
DDE
I
R
E
F
V
C
H
E
G
-----
Y
V
S
V
L
P
F
A
L
K
L
I
P
--
K
N
S
P
K
L
E
K
-
V
V
A
L
M
S
D
P
E
K
--
I
--
F
S
D
Y
G
LLSLSRQDD
Y
F
G
---
K
D
E
N
Y
W
R
G
P
-
I
W
M
N
--
I
N
Y
L
C
L
---
D
A
M
R
Y
Y
Y
-------
P
E
V
I
L
-
D
V
A
G
-------
E
A
S
--
N
-
A
K
K
L
Y
-
Q
-
S
-
L
K
-
I
-
N
L
-----
S
N
N
I
Y
K
V
W
E
E
Q
G
Y
C
YE
N
Y
S
P
I
D
G
H
G
T
G
A
E
H
F
T
G
W
T
A
L
V
V
N
I
L
G
R
F
R
S
H
H
H
H
H
H
--------
22
Fugue
75.38
17%
-93
- C1 -
4QFH
2
?
A:
[6-615]
------H
H
H
M
K
D
Q
Y
L
K
D
L
T
V
H
L
N
E
S
N
A
A
P
A
N
T
S
M
A
---
V
A
S
F
N
M
P
H
--
E
I
--------
T
R
R
M
------
R
P
L
G
V
D
A
D
------
T
S
L
T
S
C
P
S
W
R
R
L
Q
E
L
Y
---
E
I
H
G
S
---
E
S
----------------------
I
L
K
--
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
V
D
L
R
S
S
D
-
K
N
F
V
F
-
L
D
Y
-
S
K
T
-
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
--------
R
G
I
--
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
----------
H
I
A
L
R
N
R
S
N
R
P
---
I
F
V
N
G
H
D
V
M
P
L
V
N
----
K
V
-
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
----
G
K
P
I
R
------
H
V
V
N
--
I
G
I
G
G
S
---
D
L
G
P
M
M
A
C
E
A
L
R
P
F
S
D
R
R
I
S
M
H
F
V
S
N
I
D
G
T
H
L
S
E
--------
V
L
N
L
V
D
-------------------
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
---
Q
E
T
--------------------
I
T
N
A
L
-
S
A
R
N
E
F
L
-
K
-
F
---
L
S
S
R
G
I
S
-
E
A
---
G
A
V
A
K
H
F
V
A
L
-
S
T
N
A
E
K
--
V
K
E
F
G
--------
I
D
E
E
N
M
F
Q
F
W
DWVG
G
R
Y
S
L
----
W
S
A
I
G
L
S
V
M
I
S
I
G
----
Y
D
N
F
V
E
--
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
------------
L
P
I
I
L
A
--
L
V
G
-
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
----
L
P
-------
Y
D
-----
Q
Y
L
W
---------------------
R
L
P
A
Y
L
Q
Q
L
D
M
----
E
S
N
G
K
G
A
T
K
N
G
R
M
V
-----------
S
T
H
T
G
P
I
I
F
G
E
-------
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
-
H
Q
G
T
K
L
I
---
P
C
D
F
I
G
A
I
Q
T
Q
N
-------
Y
-
I
G
E
---
H
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
--
L
M
I
G
K
T
P
E
-
E
V
K
R
E
L
E
S
A
G
GK
S
--
E
D
E
I
Q
---------
L
L
I
---
P
Q
K
T
F
T
G
G
R
-
P
--
S
--
N
S
L
L
V
K
ALT
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
-
A
I
W
G
-------
I
N
S
Y
D
Q
-
W
G
V
E
L
-
G
-
K
-
L
L
-
A
-
K
S
I
L
----------------
L
------
Q
L
Q
P
G
Q
K
V
T
N
--------
H
D
---
S
S
T
N
G
L
I
E
L
F
N
E
R
S
--
H
-
17
Fugue
74.93
23%
-109
- C3 -
5DA0
2
?
A:
[14-484]
---------------------------------------------------------------------------------------------
Q
R
E
W
F
---
A
N
P
R
K
---
D
V
L
A
G
I
--------
V
------
V
A
L
A
L
I
--
P
E
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
-
A
F
L
-
G
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
L
V
K
D
------------------------------------------
H
G
I
Q
Y
L
F
A
A
T
---
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
-
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
------
Q
F
V
G
AN
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
A
-----------------------------------------------------
M
P
S
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
G
A
D
--------------------
V
K
-
T
V
-
G
D
M
G
T
L
P
-
T
-
A
LPH
F
Q
F
P
Q
V
P
L
T
F
---
E
T
L
A
I
I
F
P
V
A
-
L
T
L
S
L
V
--
G
L
L
E
S
--------
L
L
T
A
Q
L
I
-------
D
E
R
T
D
----
T
T
S
D
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
--
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
A
G
A
F
L
M
V
L
I
L
A
--
L
Q
P
-
L
L
-----
V
Q
I
P
M
A
A
----
L
V
-------
A
V
M
M
V
V
A
I
S
T
F
---------------------
D
W
G
S
L
R
F
P
K
G
E
----
T
V
V
M
L
A
T
V
A
V
T
V
F
T
-----------
H
D
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
L
S
Q
V
T
P
V
D
E
V
D
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
---
L
H
Q
F
D
-
F
T
H
---
P
A
R
R
V
V
I
D
L
S
D
A
H
F
W
D
G
S
A
V
G
A
L
D
K
-
V
M
L
K
F
M
R
Q
G
T
--
S
V
E
L
R
G
L
N
---------
A
A
S
---
A
T
L
V
E
R
L
-------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
62.69
35%
-93
- C3 -
3LLO
1
A:
[1-143]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Y
T
V
L
G
-
Q
L
P
D
T
D
V
Y
I
D
I
D
A
Y
E
E
V
K
E
I
P
G
---
I
K
I
F
Q
-
I
N
A
---
P
I
Y
Y
A
N
S
D
L
Y
S
S
A
N
-----------------------------------------------------------------------------
I
H
T
V
I
L
D
F
T
Q
V
N
F
M
-
D
S
V
G
-------
V
K
T
L
A
G
-
I
V
K
E
Y
-
G
-
D
-
V
G
-
I
-
Y
V
Y
L
A
G
C
S
A
Q
V
V
N
D
L
T
S
N
R
F
----------
F
E
N
P
A
L
K
E
L
-
L
F
H
S
I
H
D
A
V
L
G
S
Q
V
R
E
A
-----------
2
HHSearch
57.61
14%
-122
- C3 -
3QE7
2
URAA_ECOLI
A:
[12-410]
-----------------------------------------------------------------------------------------------------
P
P
L
L
Q
---
T
I
P
L
S
L
--------
Q
H
L
F
A
M
F
G
A
T
V
L
V
--
P
V
L
F
H
------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
-
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
-------------------------------------------
L
G
Y
E
V
A
L
G
G
F
---
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
-
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
------
M
A
G
L
--
L
P
--
A
-
E
G
---------------
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
--------
G
S
V
L
F
R
G
---------------
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
--------------------
D
---
T
-
T
P
I
I
N
A
H
W
F
-
A
---
L
P
T
L
Y
T
P
-
R
F
---
E
--
W
F
A
I
L
T
I
-
L
P
A
A
L
V
--
V
I
A
E
H
--------
V
G
H
L
V
V
T
-------
A
N
I
V
K
KDLL
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
--
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
R
V
Y
S
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
L
A
A
-
A
I
Q
M
-
I
P
L
P
V
M
G
G
V
----
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
-----------------------
K
V
D
Y
N
--
K
A
Q
----
N
L
I
L
T
S
V
I
L
I
I
G
V
S
GAKVNIGAAEL
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
53.95
18%
-86
- C3 -
1SBO
-
Y1442_THEMA
A:
[10-110]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
D
D
---
K
A
I
V
R
-
V
Q
G
---
D
I
D
A
Y
N
S
S
E
L
K
E
Q
L
R
--
N
F
I
S
-------------------------------------------------------------------
T
T
S
K
K
K
I
V
L
D
L
S
S
V
S
Y
M
-
D
S
A
G
-------
L
G
T
L
V
V
-
I
L
K
D
A
-
K
-
I
-
N
G
-
K
-
E
F
I
L
S
S
L
K
E
S
I
S
R
I
L
K
L
T
H
L
D
------
K
--
I
------
F
K
-
I
T
D
T
V
E
E
A
--------------------
8
HHSearch
52.56
15%
-82
- C3 -
1TH8
-
SP2AA_GEOSE
B:
[9-114]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
Q
D
---
V
L
I
V
R
-
L
S
G
---
E
L
D
H
H
T
A
E
E
L
R
E
Q
V
T
--
D
V
L
E
-------------------------------------------------------------------
N
R
A
I
R
H
I
V
L
N
L
G
Q
L
T
F
M
-
D
S
S
G
-------
L
G
V
I
L
G
-
R
Y
K
Q
I
-
K
-
N
-
V
G
-
G
-
Q
M
V
V
C
A
V
S
P
A
V
K
R
L
F
D
M
S
G
L
F
------
K
--
I
------
I
R
-
V
E
A
D
E
Q
F
A
L
Q
A
L
G
V
A
-------------
5
HHSearch
52.44
11%
-73
- C3 -
2KA5
-
Y1081_THEMA
A:
[5-124]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
H
H
H
H
H
H
M
F
P
Y
K
I
V
D
D
---
V
V
I
L
M
-
P
N
K
---
E
L
N
I
E
N
A
H
L
F
K
K
W
V
F
--
D
E
F
L
-------------------------------------------------------------------
N
K
G
Y
N
K
I
F
L
V
L
S
D
V
E
S
I
-
D
S
F
S
-------
L
G
V
I
V
N
-
I
L
K
S
I
-
S
-
S
-
S
G
-
G
-
F
F
A
L
V
S
P
N
E
K
V
E
R
V
L
S
L
T
N
L
D
------
R
--
I
------
V
K
-
I
Y
D
T
I
S
E
A
M
E
E
V
R
R
K
-------------
7
HHSearch
51.93
18%
-77
- C3 -
1H4X
1
SP2AA_LYSSH
A:
[8-112]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
E
---
T
V
V
I
R
-
L
F
G
---
E
L
D
H
H
A
V
E
Q
I
R
A
K
I
S
--
T
A
I
F
-------------------------------------------------------------------
Q
G
A
V
T
T
I
I
W
N
F
E
R
L
S
F
M
-
D
S
S
G
-------
V
G
L
V
L
G
-
R
M
R
E
L
-
E
-
A
-
V
A
-
G
-
R
T
I
L
L
N
P
S
P
T
M
R
K
V
F
Q
F
S
G
L
G
------
P
--
W
------
M
--
M
D
A
T
E
E
E
A
I
D
R
V
R
---------------
6
HHSearch
50.73
21%
-85
- C3 -
3NY7
2
?
A:
[14-118]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
D
---
V
L
V
L
R
-
V
I
G
---
P
L
F
F
A
A
A
E
G
L
F
T
D
L
E
--
S
R
L
---------------------------------------------------------------------
E
G
K
R
I
V
I
L
K
W
D
A
V
P
V
L
-
D
A
G
G
-------
L
D
A
F
Q
R
-
F
V
K
R
L
-
P
---
E
G
-
C
-
E
L
R
V
C
N
V
E
F
Q
P
L
R
T
M
A
R
A
G
I
Q
------
P
--
I
---
P
G
R
L
A
-
F
F
P
N
R
R
A
A
M
A
D
L
----------------
4
HHSearch
50.08
23%
-29
- C3 -
2KLN
-
?
A:
[1-124]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
V
P
G
---
L
V
V
Y
R
-
Y
D
A
---
P
L
C
F
A
N
A
E
D
F
R
R
R
A
L
--
T
V
V
D
-------------------------------------------------------------
Q
----
D
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
-
D
L
T
A
-------
L
D
A
L
D
Q
-
L
R
T
E
L
-
L
-
R
-
R
G
-
I
-
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
L
------
D
--
K
---
I
G
E
D
H
-
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
-------------
19
Fugue
50.00
24%
-21
- C3 -
2KLN
-
?
A:
[1-124]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
V
P
G
---
L
V
V
Y
R
-
Y
D
A
---
P
L
C
F
A
N
A
E
D
F
R
R
R
A
L
--
T
V
V
D
Q
D
P
G
-----------------------------------------------------------------
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
-
D
L
T
A
-------
L
D
A
L
D
Q
-
L
R
T
E
L
-
L
-
R
-
R
G
-
I
-
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
-----------
L
D
K
I
G
E
D
H
-
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
-------------
10
HHSearch
49.65
15%
-86
- C3 -
3T6O
-
?
A:
[10-120]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
A
Q
---
V
T
V
I
S
-
F
P
A
VFQ
R
L
R
E
T
E
V
E
Q
I
A
S
T
F
L
--
A
A
M
Q
-------------------------------------------------------------------
G
A
Q
P
R
K
V
L
I
D
L
E
G
V
E
F
F
-
G
S
S
F
-------
I
E
L
L
V
R
-
G
W
K
R
I
-
K
-
E
D
Q
Q
-
G
-
V
F
A
L
C
S
V
S
P
Y
C
V
E
V
L
Q
V
T
H
I
D
------
E
--
V
------
W
P
-
R
Y
S
T
K
Q
E
A
L
L
A
M
A
---------------
23
Fugue
49.61
13%
-20
* C3 *
3MGL
-
?
A:
[2-129]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
S
Y
E
L
A
Q
H
G
R
S
--
T
--
L
P
R
E
L
---------
A
V
Y
---
A
L
E
G
P
F
F
F
A
-
A
--
A
--
E
T
F
E
R
V
M
--
G
S
I
Q
E
T
P
Q
I
L
I
L
R
L
K
W
V
P
F
M
D
I
T
G
-------
I
Q
T
L
E
E
M
I
-
Q
S
F
-
H
-
K
-
R
G
-
I
-
K
V
L
I
S
G
A
N
S
R
V
S
Q
K
L
V
K
A
G
I
V
------
K
L
V
-----
G
E
Q
N
-
V
Y
P
V
F
E
G
A
L
S
A
A
L
T
E
I
E
A
Q
---------
12
HHSearch
45.97
14%
-39
- C3 -
3AGD
-
?
A:
[324-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
---
R
V
F
L
H
-
L
Q
G
---
V
I
R
F
G
G
A
E
A
V
L
D
A
L
T
--
D
L
R
T
--------
G
W
D
A
A
V
Y
--
P
--
R
W
Q
E
A
---------
A
A
D
R
A
A
L
S
A
A
T
G
G
G
A
V
H
--
E
A
A
A
A
A
A
------
N
D
G
P
I
R
T
V
V
L
N
L
A
R
V
D
R
I
-
D
D
V
G
-------
R
R
L
I
A
E
-
G
V
R
R
L
-
Q
-
A
-
D
G
-
V
-
R
V
E
V
E
D
P
E
R
I
L
P
L
-------------------------------------------------------
13
HHSearch
44.78
14%
-54
- C3 -
2OOK
5
?
A:
[18-126]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
F
---
F
V
T
L
K
-
A
I
G
---
T
L
T
H
E
D
Y
L
V
I
T
P
M
L
E
--
G
A
L
S
-----------------------------------------------------------------
Q
V
D
Q
P
K
V
S
L
F
L
D
A
T
E
L
D
G
W
-
D
L
R
A
-------
A
--
W
D
D
-
L
K
L
G
L
K
H
-
K
-
S
E
F
E
-
R
V
A
I
L
G
N
K
D
W
Q
E
W
A
A
K
I
G
S
W
F
------
I
------
A
G
E
I
K
-
Y
F
E
D
E
D
D
A
L
K
W
L
R
Y
--------------
1
PsiBlast_PDB
40.74
28%
-121
- C3 -
5DA0
2
?
A:
[14-149]
-----------------------------------------------------------------------------------------------
Q
-
R
---
E
W
F
A
N
P
R
K
D
V
L
A
G
I
--------
V
------
V
A
L
A
L
I
--
P
E
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
G
-
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
L
V
K
D
-------------------------------------------
H
G
I
Q
Y
L
F
A
A
T
---
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
-
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
------
Q
F
V
G
--
A
N
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
A
M
P
S
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
--------
G
A
D
V
K
T
V
G
D
----------
M
G
T
L
P
T
A
L
P
H
F
Q
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
--------------------
P
V
A
L
T
-
L
S
L
V
G
L
L
-
E
-
S
---
L
L
T
A
Q
L
I
-
D
E
---
R
T
D
T
T
S
D
K
N
V
-
E
S
R
G
Q
G
--
V
A
N
I
V
--------
T
G
F
F
G
G
M
-------
A
G
C
A
M
----
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
A
G
A
--
F
L
M
V
L
I
L
A
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
V
V
A
I
S
T
F
D
W
G
S
L
--
R
F
P
-
K
G
E
T
-
V
V
M
L
A
T
V
A
V
----
T
V
-------
F
T
H
D
L
S
L
G
V
L
I
---------------------
G
V
V
L
S
A
L
F
F
A
R
----
K
V
S
Q
L
S
Q
V
T
P
V
D
E
V
-----------
D
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
D
F
T
H
P
A
R
-
R
V
V
I
D
L
S
D
A
H
F
W
D
G
S
A
V
G
A
L
D
K
---
V
M
L
K
F
-
M
R
Q
---
G
T
S
V
E
L
R
G
L
N
A
A
S
A
T
--
L
V
E
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
35.89
19%
-17
- C3 -
3OIZ
-
?
A:
[399-478]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
G
R
---
E
R
I
Y
R
-
V
E
G
---
Q
L
F
Y
A
S
V
E
D
F
M
A
A
F
D
--
F
R
E
----------------------------------------------------------------------
A
L
D
R
V
V
I
D
V
S
R
A
H
I
W
-
D
I
S
S
-------
V
Q
A
L
D
M
-
A
V
L
K
F
-
R
-
R
-
E
G
-
A
-
E
V
R
I
V
G
M
N
E
A
S
E
T
M
V
-----------------------------------------------------
14
HHSearch
34.02
14%
33
- C3 -
2Q3L
4
?
A:
[53-126]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
V
A
L
I
D
I
T
E
L
D
G
L
-
S
L
H
A
-------
A
--
W
D
D
-
L
K
L
G
L
-
K
H
G
-
K
E
-
F
K
R
V
A
I
I
G
Q
G
E
L
Q
E
W
A
T
R
V
A
N
W
F
------
T
------
P
G
E
F
K
-
F
F
E
D
K
R
D
A
L
D
W
L
C
---------------