@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S26A6_HUMAN: (2015-12-10 )
MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60......-..70........80--------......--..90--..---.......------100.......110--......------.120.......130..-...-...140........150.......160.......170.--------......180..-.....190.......200---.---.......210.......220.......230....---...240---.......250.......260.......270.......280.......290.......300.......310-.......320.....-..330.......340....--...350.......360.......370---........380.......390.......400.......410.......420.......430--.......440.......450-----.........460.......470.......480....-----------.-.-.490.......500.....-..510-----------.........520.......530.......540.......550---.........560.......570.......580.......590.......600.......610.....-..620.......630.......640.......650.......660.......670.......680.......690......-.700.......710.......720.......730.......740.......750.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGLADASGP
R
D
T
Q
A
L
L
S
A
T
Q
A
M
D
L
R
R
RDYHMERPLL
N
Q
E
H
L
E
E
LGRWGSAPR
T
H
Q
W
R
T
W
L
Q
C
S
R
A
R
A
-
Y
A
L
L
L
Q
HL
P
V
L
V
WL--------PRY
P
V
R
--
D
W
L
---
L
G
---
D
L
L
S
G
L
S
------
V
A
I
M
QLP
Q
G
L
A
Y
A
--
L
L
AGL
P
------
P
V
F
G
L
Y
S
S
F
Y
P
V
-
F
I
Y
-
F
LF-GTSRH-I
S
V
G
T
F
A
V
M
S
V
M
V
G
S
V
T
E
S
L
A
P
Q
AL
N
D
S
M
I
N
E
--------
T
A
R
D
A
A
R
V
Q
V
A
-
S
T
L
S
V
L
V
G
L
F
Q
V
G
L
G
L
I
----
H
---
F
G
F
V
V
T
Y
L
S
E
P
L
VRGY
T
T
A
A
A
V
Q
V
F
V
S
Q
L
K
Y
V
F
G
---
L
HLSSH---SG
P
L
S
L
I
Y
T
V
L
E
V
C
WKLPQSK
V
G
T
V
V
T
A
A
V
A
G
V
V
L
V
V
V
K
L
L
N
D
K
L
Q
Q
QLPMPI
P
G
E
L
L
T
L
I
GATGISYGM-GL
K
H
R
F
E
V
D
V
VGNIP-AGLVPPVAP
N
T
Q
L
F
S
K
L
VG--S
A
F
T
I
A
V
V
G
F
A
I
A
I
S
L
G
K
I
F
A
L
RHG----YRVDSN
Q
E
L
V
A
L
G
L
S
N
L
I
G
G
I
F
Q
C
FPVS
C
S
M
S
R
S
L
V
Q
ESTGGN
S
Q
V
A
G
A
I
S
S
L
F
I
L
L
I
I
V
K
--
L
G
E
L
F
H
D
L
P
K
A
V
L
A
A
I
I
I
-------
V
N
L
K
G
M
L
R
Q
L
S
D
M
R
S
L
W
KANRA
D
L
L
I
W
L
V
T
F
T
A
T
I
L
-----------
L
-N-L
D
L
G
L
V
V
A
V
I
F
S
L
L
L
V
V
V
R-TQM-------------P
H
Y
S
V
LGQVP
D
T
D
I
Y
R
D
V
A
E
Y
S
E
A
K
EVR
G
V
K
V
F
RSS
A
T
V
Y
-----
F
A
N
A
E
F
Y
S
D
A
L
K
Q
R
CGV
D
V
D
F
L
I
S
Q
K
K
K
L
L
K
K
Q
E
Q
L
K
L
K
Q
L
Q
K
E
E
K
L
R
K
Q
AASPKG
A
S
V
S
I
N
V
NT
S
L
-
E
D
M
RSNNVE
D
C
K
M
M
QVSSGDKMEDATANGQEDSKAPDGS
T
L
K
ALGLPQ
P
D
F
H
S
L
I
L
D
L
G
A
L
S
F
V
D
T
V
C
L
K
S
L
K
N
I
F
H
D
F
R
E
-
I
E
V
E
V
Y
M
AACH
S
P
V
V
S
Q
LEAGHFF
D
A
S
I
T
K
K
H
L
F
A
S
V
H
D
A
V
T
F
A
LQHPRPVPDSPVSVTRL
36
Fugue
89.87
24%
-107
- C2 -
5DA0
2
?
A:
[14-484]
----------------------------------------------------------------------------------------------
Q
R
--
E
W
F
AN
P
R
K
---
D
V
L
A
G
I
V
------
V
A
L
A
L
I
P
E
A
I
A
F
S
--
I
I
A
G
V
D
------
P
Q
V
G
L
Y
A
S
F
I
I
A
-
L
I
T
-
A
F
L
-
G
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
L
V
K
D
H
---------------------------
G
I
Q
Y
L
-
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
---
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
AN
W
Q
M
Y
A
M
V
---
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
A
M
P
S
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
G
A
D
V
K
T
V
G
D
M
--
G
T
L
P
T
A
L
P
-------------------
H
F
Q
F
--------------
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
P
--
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
D
----
T
T
S
D
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
A
G
A
F
L
M
V
L
I
L
A
--
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
V
A
I
S
T
F
D
W
G
S
L
-----
R
F
P
K
G
E
T
V
V
M
L
A
T
V
A
V
T
V
F
-----------
T
-
H
D
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
-
V
S
Q
L
S
Q
V
T
P
V
D
E
VDG
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
D
F
T
H
P
A
R
R
V
V
I
D
L
S
D
A
H
F
W
D
G
S
A
V
G
A
L
D
K
V
M
L
K
F
M
R
Q
G
T
S
V
E
L
R
G
L
N
A
A
S
A
T
L
V
E
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.34
22%
-116
- C2 -
5DA0
2
?
A:
[14-410]
------------------------------------------------------------------------------------------------QR
E
W
F
---
A
N
P
R
K
D
V
L
A
G
I
V
------
V
A
L
A
L
I
P
E
A
I
A
F
S
--
I
I
A
G
V
D
------
P
Q
V
G
L
Y
A
S
F
I
I
A
-
L
I
T
A
F
L
G
-
G
R
P
G
M
-
I
S
A
A
T
G
A
M
A
L
L
M
T
G
L
V
K
D
H
---------------------------
G
I
Q
Y
L
-
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
---
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
---
A
N
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
A
M
P
S
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
G
A
D
V
K
T
V
G
D
--
M
G
T
L
P
T
A
L
P
---------------------
H
F
Q
------------
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
P
--
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
D
----
T
T
S
D
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
A
G
A
F
L
M
V
L
I
L
A
--
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
V
A
I
S
T
F
-
D
W
G
S
L
R
----
F
P
K
G
E
T
V
V
M
L
A
T
V
A
V
T
V
F
-----------
T
H
D
-
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
L
-------------
S
Q
V
T
P
V
D
E
V
D
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
D
F
T
H
P
A
R
-----
R
V
V
I
D
L
S
D
A
H
F
W
D
G
S
A
V
G
A
L
D
K
V
M
L
K
F
M
R
Q
G
T
S
V
E
L
R
G
L
N
A
A
S
A
T
L
V
E
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
60.67
16%
-115
- C2 -
3QE7
2
URAA_ECOLI
A:
[14-410]
----------------------------------------------------------------------------------------------------
L
---
L
Q
---
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
L
V
P
V
L
F
H
--------
I
N
------
P
A
T
V
L
L
F
N
G
I
G
T
-
L
L
Y
-
L
F
I
C
K
G
K
I
P
-
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
---------------------------
L
G
Y
E
V
A
-
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
---
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
L
---
L
P
A
------
E
G
---------------
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
----
G
-
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
-
G
I
V
---
D
T
T
P
I
I
N
A
H
W
F
A
L
P
T
L
Y
T
P
R
F
E
--
W
F
A
I
L
--
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
KDLL
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
R
V
Y
S
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
-
V
-
D
Y
N
--
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
GAKVNIGAAEL
K
-
G
-
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
50.36
25%
47
- C2 -
3LLO
1
A:
[1-143]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------
P
S
Y
T
V
L
G
Q
L
P
D
T
D
V
Y
I
D
I
D
A
Y
E
E
V
K
E
I
P
G
I
K
I
F
Q
I
N
A
P
I
Y
-----
Y
A
N
S
D
L
Y
S
S
A
N
I
H
T
V
I
L
D
-----------
F
T
Q
V
N
F
M
D
S
V
G
V
K
T
L
A
G
I
V
K
E
Y
G
D
V
G
I
Y
V
Y
L
A
G
C
S
A
Q
V
V
N
D
L
T
S
N
R
F
F
E
N
P
A
L
K
E
L
L
F
H
S
I
H
D
A
V
L
G
S
Q
V
R
E
A
-------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
46.85
24%
-130
- C2 -
1U6G
-
CAND1_HUMAN
C:
[615-759]
--------------------------------------------------------------------------------------------------------------
F
L
E
R
L
K
------
N
E
I
T
R
L
T
T
V
K
A
L
T
--
L
I
A
G
S
P
LKIDL
R
P
V
L
G
---
E
G
V
P
I
-
L
A
S
-
F
L
R
-
K
N
Q
R
A
-
L
K
L
G
T
L
S
A
L
D
I
L
I
K
N
Y
S
D
S
L
T
-
A
A
M
I
D
A
V
L
D
E
LPPLI---
S
E
S
D
M
H
V
S
Q
M
A
I
S
F
L
T
T
L
A
K
V
Y
P
S
S
L
S
K
I
----
S
G
S
I
L
N
E
L
I
G
L
V
R
S
P
L
L
Q
G
G
A
L
S
A
M
L
D
F
F
Q
A
L
V
V
T
G
T
N
---
N
L
G
Y
M
D
---
L
L
R
M
L
T
G
P
V
Y
S
Q
T
H
K
Q
S
Y
Y
S
I
A
K
C
V
A
A
L
T
R
A
C
P
K
E
G
P
A
V
V
G
Q
F
I
Q
D
V
K
N
S
R
S
T
D
S
I
R
L
L
A
L
L
S
L
G
E
V
G
H
H
-
I
D
L
S
G
Q
L
E
L
K
S
V
I
L
E
-
A
F
S
S
P
S
E
E
V
K
S
A
A
S
Y
A
L
G
S
--
I
S
V
G
N
L
P
E
Y
L
P
F
V
L
Q
E
I
T
S
Q
P
K
R
Q
Y
----
L
L
L
H
S
L
K
E
I
I
S
S
A
S
V
V
G
L
K
P
Y
V
E
N
I
W
A
L
L
L
K
H
C
E
C
A
E
E
G
T
R
N
V
V
A
E
C
L
G
K
L
T
L
I
D
P
E
T
L
L
P
--
R
L
K
G
Y
L
I
S
G
S
S
Y
A
R
S
S
V
V
-------
T
A
V
K
F
T
I
S
D
H
P
Q
P
I
D
P
L
L
K
N
C
I
G
D
F
L
K
T
L
E
D
P
D
L
N
V
-----------
R
-
R
-
V
A
L
V
T
F
N
S
A
A
H
N
K
P
S
L
I
R
D
-
L
L
D
-------------
T
V
L
P
H
L
Y
N
E
T
K
V
R
K
E
L
I
R
E
V
E
M
G
P
F
K
H
T
V
D
D
G
L
D
I
R
K
A
A
F
-----
E
C
M
Y
T
L
L
D
S
C
L
D
R
L
D
I
F
E
F
L
N
H
V
E
D
G
L
K
D
H
Y
D
I
K
M
L
T
F
L
M
L
V
R
L
S
T
L
C
P
S
A
V
L
Q
R
L
D
R
L
V
E
P
L
R
A
T
C
-
T
T
K
V
K
A
N
S
V
K
Q
E
F
E
K
Q
D
E
L
K
R
S
A
M
R
A
V
A
A
L
L
T
I
P
E
A
E
K
S
P
L
M
S
E
F
Q
S
Q
I
S
S
N
P
E
L
A
A
--------------------------------------------------------------------------------------
27
HHSearch
45.07
16%
-55
- C2 -
1TH8
-
SP2AA_GEOSE
B:
[42-114]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
R
H
I
V
L
N
L
G
Q
L
T
F
M
D
S
S
G
L
G
V
I
L
G
R
Y
K
Q
I
K
N
-
V
G
G
Q
M
V
V
C
A
V
S
P
A
V
K
R
L
F
D
M
S
G
L
F
K
----
I
I
R
V
E
A
D
E
Q
F
A
L
Q
A
L
G
V
A
--------------
10
PsiBlast_PDB
44.84
23%
-71
- C2 -
4D2C
4
?
A:
[331-472]
----------------------------------------------------------------------
F
I
M
L
Y
T
P
F
F
A
W
L
W
T
A
W-----
S
S
P
T
K
---
F
A
---
V
G
---
L
M
F
A
G
L
S
------
F
L
L
M
A
I
P
G
A
L
-------------------
Y
G
T
S
G
K
V
S
P
L
-
W
----
L
V
-
G
S
W
A
L
-
V
I
L
G
E
M
L
I
S
P
V
-----------------
M
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
-
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
----
V
---
L
G
I
V
L
V
F
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
44.57
24%
-129
- C2 -
4A0C
-
CAND1_HUMAN
A:
[638-782]
--------------------------------------------------------------------------------------------------------------
F
L
E
R
L
K
------
N
E
I
T
R
L
T
T
V
K
A
L
T
--
L
I
A
G
S
P
LKIDLR
P
V
L
G
---
E
G
V
P
I
-
L
A
S
-
F
L
R
-
K
N
Q
R
A
-
L
K
L
G
T
L
S
A
L
D
I
L
I
K
N
Y
S
D
S
L
T
-
A
A
M
I
D
A
V
L
D
E
LPPLI---
S
E
S
D
M
H
V
S
Q
M
A
I
S
F
L
T
T
L
A
K
V
Y
P
S
S
L
S
K
I
----
S
G
S
I
L
N
E
L
I
G
L
V
R
S
P
L
L
Q
G
G
A
L
S
A
M
L
D
F
F
Q
A
L
V
V
T
G
T
N
---
N
L
G
Y
M
D
---
L
L
R
M
L
T
G
P
V
Y
S
Q
K
Q
S
Y
Y
S
I
A
K
C
V
A
A
L
T
R
A
C
P
K
E
G
P
A
V
V
G
Q
F
I
Q
D
V
K
N
S
R
S
T
D
S
I
R
L
L
A
L
L
S
L
G
E
V
G
H
H
I
D
-
L
S
G
Q
L
E
L
K
S
V
I
L
E
A
F
-
S
S
P
S
E
E
V
K
S
A
A
S
Y
A
L
G
S
I
S
--
V
G
N
L
P
E
Y
L
P
F
V
L
Q
E
I
T
S
Q
P
K
R
Q
Y
L
L
----
L
H
S
L
K
E
I
I
S
S
A
S
V
V
G
L
K
P
Y
V
E
N
I
W
A
L
L
L
K
H
C
E
C
A
E
E
G
T
R
N
V
V
V
E
C
L
G
K
L
T
L
I
D
P
E
T
L
L
P
R
L
--
K
G
Y
L
I
S
G
S
S
Y
A
R
S
S
V
V
T
A
-------
V
K
F
T
I
S
D
H
P
Q
P
I
D
P
L
L
K
N
C
I
G
D
F
L
K
T
L
E
D
P
D
L
N
V
R
R
-----------
V
-
A
-
L
V
T
F
N
S
A
A
H
N
K
P
S
L
I
R
D
L
L
-
D
T
V
-------------
L
P
H
L
Y
N
E
T
K
V
R
K
E
L
I
R
E
V
E
M
G
P
F
K
H
T
V
D
D
G
L
D
I
R
K
A
A
F
E
C
-----
M
Y
T
L
L
D
S
C
L
D
R
L
D
I
F
E
F
L
N
H
V
E
D
G
L
K
D
H
Y
D
I
K
M
L
T
F
L
M
L
V
R
L
S
T
L
C
P
S
A
V
L
Q
R
L
D
R
L
V
E
P
L
R
A
T
C
T
T
-
K
V
K
A
N
S
V
K
Q
E
F
E
K
Q
D
E
L
K
R
S
A
M
R
A
V
A
A
L
L
T
I
P
E
A
E
K
S
P
L
M
S
E
F
Q
S
Q
I
S
S
N
P
E
L
A
A
I
F
E
S
I
Q
----------------------------------------------------------------------------------
8
PsiBlast_PDB
42.47
23%
-66
- C2 -
4APS
-
?
A:
[331-471]
----------------------------------------------------------------------
F
I
M
L
Y
T
P
F
F
A
W
L
W
T
AWKKN---
S
P
T
K
---
F
A
---
V
G
---
L
M
F
A
G
L
S
------
F
L
L
M
A
I
P
G
A
L
-------------------
Y
G
T
S
G
K
V
S
P
L
-
W
----
L
V
-
G
S
W
A
L
-
V
I
L
G
E
M
L
I
S
P
V
G
L
-
S
V
T
T
K
L
A
P
K
A
F
N
S
Q
M
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
-
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
----
V
---
L
G
I
V
L
V
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
41.82
23%
-6
- C2 -
2KLN
-
?
A:
[1-124]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
V
P
G
L
V
V
Y
R
Y
D
A
P
L
C
-----
F
A
N
A
E
D
F
R
R
R
A
L
T
V
V
D
Q
-------------------------------------------------------------------------------------------------
D
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
D
L
T
A
L
D
A
L
D
Q
L
R
T
E
L
L
R
-
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
L
D
K
-
I
G
E
D
H
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
--------------
9
PsiBlast_PDB
41.68
23%
-64
- C2 -
4D2B
5
?
A:
[331-472]
----------------------------------------------------------------------
F
I
M
L
Y
T
P
F
F
A
W
L
W
T
ANQ---
P
S
S
P
T
K
---
F
A
---
V
G
---
L
M
F
A
G
L
S
------
F
L
L
M
A
I
P
G
A
L
-------------------
Y
G
T
S
G
K
V
S
P
L
-
W
----
L
V
-
G
S
W
A
L
-
V
I
L
G
E
M
L
I
S
P
V
G
L
-
S
V
T
T
----------
M
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
-
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
----
V
---
L
G
I
V
L
V
F
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
41.40
30%
-22
- C2 -
4P6I
-
CAS1_ECOLI
C:
[123-217]
------------------------------------------
R
F
G
E
P
A
P
A
R
R
S
V
E
Q
L
R
G
I
E
G
S
R
V
R
A
T
Y
A
L
L
A
K
Q
Y
G
V
T
W
N
G
--------
R
R
Y
D
P
K
--
D
W
E
---
K
G
---
D
T
I
N
Q
C
I
------
S
A
A
T
S
C
L
Y
G
V
T
E
A
AI
L
A
A
G
Y
A
------
P
A
I
G
F
V
H
T
G
K
P
L
S
F
V
Y
-
D
I
A
-
D
I
I
K
F
-
D
T
V
V
P
K
A
F
E
I
A
R
R
N
P
G
E
P
D
R
E
V
R
L
A
C
R
D
I
F
R
S
--------
S
K
T
L
A
K
L
I
P
L
I
-
E
D
V
L
A
A
G
E
I
Q
P
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
41.04
23%
-67
- C2 -
4XNI
6
?
A:
[331-473]
----------------------------------------------------------------------
F
I
M
L
Y
T
P
F
F
A
W
L
W
T
A
W
KKNQ
P
S
S
P
T
K
---
F
A
---
V
G
---
L
M
F
A
G
L
S
------
F
L
L
M
A
I
P
G
A
L
-------------------
Y
G
T
S
G
K
V
S
P
L
-
W
----
L
V
-
G
S
W
A
L
-
V
I
L
G
E
M
L
I
S
P
V
G
L
-
S
V
-------------
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
-
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
----
V
---
L
G
I
V
L
V
F
L
S
K
R
I
Q
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
41.02
23%
-64
- C2 -
4D2D
5
?
A:
[331-473]
----------------------------------------------------------------------
F
I
M
L
Y
T
P
F
F
A
W
L
W
T
A
WKKNQ
P
S
S
P
T
K
---
F
A
---
V
G
---
L
M
F
A
G
L
S
------
F
L
L
M
A
I
P
G
A
L
-------------------
Y
G
T
S
G
K
V
S
P
L
-
W
----
L
V
-
G
S
W
A
L
-
V
I
L
G
E
M
L
I
S
P
V
G
L
-
S
V
T
T
K
------
N
S
Q
M
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
-
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
----
V
---
L
G
I
V
L
V
F
L
S
K
R
I
Q
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
39.66
27%
-24
- C2 -
3NKE
2
CAS1_ECOLI
A:
[3-126]
--------
A
R
S
D
K
L
L
Y
Q
A
K
L
A
L
D
---
E
D
L
R
L
K
--
V
V
R
K
M
F
E
L
R
F
G
E
P
A
P
A
R
R
S
V
E
Q
L
R
G
I
E
G
S
R
V
R
A
T
Y
A
L
L
A
K
Q
Y
G
V
T
W
N
G
--------
R
R
Y
D
------
E
---
K
G
---
D
T
I
N
Q
C
I
------
S
A
A
T
S
C
L
Y
G
V
T
E
A
A
I
L
A
A
G
Y
A
------
P
A
I
G
F
V
H
T
G
K
P
L
S
F
V
Y
-
D
I
A
-
D
I
I
K
F
-
D
T
V
V
P
K
A
F
E
I
A
R
R
N
P
G
E
P
D
R
E
V
R
L
A
C
R
D
I
F
R
S
--------
S
K
T
L
A
K
L
I
P
L
I
-
E
D
V
L
A
A
G
E
I
Q
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
39.38
12%
-33
- C2 -
3T6O
-
?
A:
[47-120]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
R
K
V
L
I
D
L
E
G
V
E
F
F
G
S
S
F
I
E
L
L
V
R
G
W
K
R
I
K
E
D
Q
Q
G
V
F
A
L
C
S
V
S
P
Y
C
V
E
V
L
Q
V
T
H
I
D
E
----
V
W
P
R
Y
S
T
K
Q
E
A
L
L
A
M
A
----------------
26
HHSearch
39.12
10%
-28
- C2 -
1H4X
1
SP2AA_LYSSH
A:
[42-112]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
T
I
I
W
N
F
E
R
L
S
F
M
D
S
S
G
V
G
L
V
L
G
R
M
R
E
L
E
A
-
V
A
G
R
T
I
L
L
N
P
S
P
T
M
R
K
V
F
Q
F
S
G
L
G
P
----
W
M
-
M
D
A
T
E
E
E
A
I
D
R
V
R
----------------
28
HHSearch
39.05
21%
-33
- C2 -
1SBO
-
Y1442_THEMA
A:
[44-110]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
K
I
V
L
D
L
S
S
V
S
Y
M
D
S
A
G
L
G
T
L
V
V
I
L
K
D
A
K
I
-
N
G
K
E
F
I
L
S
S
L
K
E
S
I
S
R
I
L
K
L
T
H
L
D
K
----
I
F
K
I
T
D
T
V
E
E
A
---------------------
24
HHSearch
38.40
12%
-35
- C2 -
2KA5
-
Y1081_THEMA
A:
[52-124]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
F
L
V
L
S
D
V
E
S
I
D
S
F
S
L
G
V
I
V
N
I
L
K
S
I
S
S
-
S
G
G
F
F
A
L
V
S
P
N
E
K
V
E
R
V
L
S
L
T
N
L
D
R
----
I
V
K
I
Y
D
T
I
S
E
A
M
E
E
V
R
R
K
--------------
16
PsiBlast_PDB
35.84
33%
-12
- C2 -
3BHS
-
?
A:
[202-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
M
P
Q
T
I
V
N
T
L
L
A
L
C
G
A
T
L
A
T
Y
F
L
S
A
L
F
H
K
G
K
A
S
I
V
D
M
A
N
-
A
A
L
A
G
G
V
A
I
G
S
--
V
C
N
I
V
G
P
V
G
A
F
V
I
G
L
L
G
G
A
I
S
V
-
V
G
F
V
F
I
Q
P
M
L
----
E
S
K
A
K
T
I
D
T
C
G
V
H
N
L
H
G
L
P
G
L
L
G
G
F
S
A
I
L
I
V
P
G
I
A
V
A
Q
L
T
G
I
G
I
T
L
A
L
A
L
I
G
G
V
I
A
G
A
L
I
K
--
L
T
G
T
T
K
Q
A
Y
E
D
S
H
E
F
I
H
L
-------
A
G
P
E
D
E
H
K
A
E
R
L
V
L
E
A
K
T
E
I
Q
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------