@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S26A7_HUMAN: (2015-12-10 )
MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------.........10........20------.........30........40........50.....------...60........70.......--.80........90..-....---..100......-----.110-.........120.......130.......140....--------...150-........160...----....170-..--......180.......190------.---......----------.200.......210..--.....220...-------....230.......240.......250..--.....260.......270----.........280.---------------......290.--------.--...---...300----........310.---------------------.-------....----.320-------......-----..330...----....----340.......350..----------.....360--------------....------...370.....-.---------.380..-.....390....------...400..-------.....410..-------.------------....420...-------------------....430.......-440....-----...-----------450.......460---------.......470------.......480.......490.......500...----....---510.......520.......530..--------...-..540...-...----.-550........560...-....570.......580.......590...------------------..--.------------.-600......---..610.......620..--.-.-...630.......640.......650....-------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------MTG
A
K
R
K
K
K
S
M
L
W
SKMHTP
Q
-------
C
E
D
I
I
Q
W
C
R
RRLPILDWAPHYN
L
K
E
NLL
P
D
T
V
S
G
I
M
------
L
A
V
Q
Q
V
T
Q
G
L
A
F
A
V
L
S
SV
H
P
V
F
--
G
L
Y
G
S
L
F
P
A
I
I
Y
A
I
F
-GMGH---HVA
T
G
T
F
A
L
T
S
-----
L
I
---
S
A
N
A
V
E
R
I
V
P
Q
N
M
Q
N
LTTQSN
T
S
V
L
GLSDFE
M
Q
R
I
H
--------
V
A
A
A
V
--
S
F
L
G
G
V
I
Q
V
A
M
F
V
L
----
Q
LGS
A
T
--
F
V
--
V
T
E
P
V
I
S
A
M
TTGA
A
T
H
V
V
-------
T
---
S
Q
V
K
Y
L
----------LGMKMPYISG
P
L
G
F
F
Y
--
I
Y
A
Y
V
F
E
N
I
K
S
-------
V
R
L
E
A
L
L
L
S
L
L
S
I
V
V
L
V
L
V
K
E
L
N
E
Q
F
K
R
K--
I
K
V
V
L
P
V
D
L
V
L
I
I
A
A
S
------
F
A
C
Y
CTNMENTYG---------------
L
E
V
V
GHIP-Q--------G--IPS---PRAP-
P
----
M
N
I
L
S
A
V
I
T
E
A
F
---------------------
G
-------
V
A
L
V
----
G
Y
V
--------
A
S
L
A
L
A-----QGSA
K
K
F
K
----
Y
SID----D
N
Q
E
F
L
A
H
G
L
S
N
I
V
S
----------
S
F
F
F
CIP
S
--------------
A
A
AM------GRTAGLYSTGA-
K
---------
T
Q
V
A
C
L
-
I
S
C
I
F
V
L
I
V
I
Y
A
------
I
G
P
L
L
Y
W
L
-------
P
M
C
V
L
A
S
I
I
V
-------
V
------------GLK
G
M
L
I
Q
F
R
-------------------
D
L
K
K
YWNVDKID
W
G
-
I
W
V
S
T
Y
V
-----
F
T
I
-----------
C
F
A
A
N
V
G
L
L
F
G
V
V
---------
C
T
I
A
I
V
I
GRF------P
R
A
M
T
V
S
IKNM
K
E
M
E
F
K
V
KTEM
D
S
E
T
L
Q
Q
V
K
I
I
----SINN---
P
L
V
F
L
N
A
K
K
F
Y
T
D
L
M
N
M
I
Q
K
ENACN--------Q
P
L
-
D
D
I
S
K
C
E
Q
-
N
T
L
----
L
-
N
S-LSNGNCN
E
E
A
S
QSC-PNE
K
C
Y
L
I
L
DCSG
F
T
F
FDY
S
G
V
S
M
L
V
E
V
Y
M
------------------DC--K------------G-RS-
V
D
V
L
L
A
---
H
C
T
A
S
L
I
K
A
M
T
YYGNLD--S-E-KP
I
F
F
E
S
V
S
A
A
I
S
H
I
HSNKN
L
S
KLSDHSEV-------------------------------------------------------------------------------
18
Fugue
95.84
23%
-129
- C5 -
5DA0
2
?
A:
[14-484]
-----------------------------------------------------------------------------------------------------------------------------
Q
R
E
W
F
A
N
P
R
K
D
V
L
A
G
I
V
------
V
A
L
A
L
I
P
E
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
--
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
G
R
P
---
G
M
I
S
A
A
T
G
A
M
A
-----
L
L
---
M
T
G
L
V
K
D
-------------------------
H
G
I
Q
--------
Y
L
F
A
A
--
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
A
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Y
L
--
K
F
--
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
-------
M
---
A
Q
L
P
Q
F
----------
V
G
-------------------------
A
N
-------
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
-----
L
P
L
V
F
K
A
-------
M
P
S
A
L
V
A
I
V
V
L
T
------
V
V
A
V
V
T
G
A
D
V
K
-
T
---------------
V
G
D
M
G
T
L
P
-
T
--------
A
--
L
P
H
---
F
Q
F
P
-
Q
VPLT
F
E
T
L
A
I
I
F
P
V
A
L
---------------------
T
-------
L
S
L
V
----
G
L
L
--------
E
S
L
L
T
A
-----
Q
L
I
D
E
R
T
D
----
T
T
S
D
----
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
----------
G
F
F
G
G
M
A
G
--------------
C
A
M
I
------
G
Q
S
M
I
N
V
T
S
G
G
-
R
---------
G
R
L
S
T
F
-
V
A
G
A
F
L
M
V
L
I
L
A
------
L
Q
P
L
L
V
Q
I
-------
P
M
A
A
L
V
A
V
M
M
-------
V
------------
V
A
I
S
T
F
----------------------------------
D
W
G
S
L
R
F
P
K
G
E
-----
T
V
V
-----------
M
L
A
T
V
A
V
T
V
F
T
H
D
---------
L
S
L
G
V
L
I
G
V
V
------
L
S
A
L
F
F
A
R
K
V
S
Q
L
S
Q
V
T
P
V
D
E
V
D
G
T
R
T
Y
R
V
R
---------
G
---
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
--------------------------------------------------------
D
F
-
T
H
P
A
R
R
V
V
I
D
L
S
D
A
H
F
W
D
G
S
A
V
G
A
L
D
K
V
M
L
------------------
K
F
--
M
------------
R
-
Q
G
-
T
S
V
E
L
R
GL
N
A
A
S
A
T
L
V
E
R
L
--------------------------------------------------------------------------------------------------------------------------
25
Fugue
71.15
14%
-112
- C2 -
4BSM
-
XPO1_HUMAN
A:
[3-1017]
----------------------------------A
I
M
T
M
L
A
D
H
A
A
R
Q
L
L
D
F
SQKL
D
I
N
L
L
D
N
V
V
N
C
L
Y
H
G
E
G
A
Q
Q
R
M
A
Q
E
V
L
T
H
L
K
E
H
P
D
A
W
T
R
V
D
T
Q
N
M
N
T
K
Y
Y
G
L
Q
I
L
E
N
V
I
K
T
R
W
K
I
L
P
R
N
Q
C
E
G
I
K
K
Y
V
V
G
L
I
I
K
T
S
S
------
D
P
T
C
V
E
K
E
K
V
Y
I
G
K
L
N
M
I
L
V
Q
I
L
K
Q
E
W
P
K
H
W
P
T
F
I
S
D
I
V
-
G
A
S
R
TS
E
S
L
C
Q
N
N
M
V
I
L
K
-----
L
L
---
S
E
E
V
I
T
Q
V
K
S
K
H
L
K
D
S
M
C
N
E
F
S
Q
I
F
Q
L
C
Q
F
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M
E
N
S
Q
N
A
P
L
V
H
A
T
L
E
T
L
L
--
R
F
L
N
W
I
P
L
G
Y
I
F
E
T
----
K
L
I
S
T
L
--
I
Y
KF
L
N
V
P
M
F
R
N
V
S
L
K
C
L
T
E
I
A
G
VSVSQY
E
---
E
Q
F
V
T
L
----------
F
T
L
T
M
M
Q
L
K
Q
M
L
P
L
N
T
--
N
I
R
L
A
Y
S
N
G
K
---------
D
D
E
Q
N
F
I
Q
N
L
S
L
F
L
C
T
F
L
K
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H
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Q
L
I
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LN
L
R
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T
L
M
E
A
L
H
Y
M
L
L
V
S
E
VEETE
I
F
K
I
C
L
E
Y
W
N
H
L
A
---------------
A
E
L
Y
R
E
S
P
-
F
STSASPHF
D
--
V
P
P
---
R
R
Q
L
-
Y
----
L
P
M
L
F
K
V
R
L
L
M
V
---------------------
S
R
MAKPEE
V
L
V
V
E
N
DQ
G
E
V
V
R
E
F
MKDT
D
S
I
N
L
Y
-----
K
N
M
R
E
T
L
V
----
Y
L
T
H
L
D
Y
V
D
T
E
R
I
M
T
E
K
L
H
N
Q
V
N
GTEWS
W
K
N
L
N
T
L
C
W
A
I
G
S
I
SGAMH
E
E
D
E
K
R
F
L
V
T
V
I
------
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D
L
L
G
L
C
E
Q
K
R
G
K
---------
D
N
K
A
I
I
-
A
S
N
I
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Y
I
V
G
Q
Y
P
------
R
F
L
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A
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W
K
-------
F
L
K
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V
V
N
K
L
F
-------
E
F
M
H
ETHDG
V
Q
D
M
A
C
D
T
F
I
K
I
A
Q
-------------------
K
C
R
R
H
F
V
Q
V
Q
V
G
E
V
-
M
P
F
I
D
E
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-----
L
N
N
-----------
I
N
T
I
I
C
D
L
Q
P
Q
Q
V
---------
H
T
F
Y
E
A
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G
Y
M
I
G
A
QTD
Q
T
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Q
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H
L
I
E
K
Y
M
L
L
P
N
Q
V
W
D
S
I
L
K
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N
V
R
A
C
K
A
V
GHPF
V
I
Q
L
---
G
R
I
Y
L
D
M
L
N
V
Y
K
C
L
S
E
N
I
S
A
A
I
Q
A
N
MVTKQ
P
L
I
R
S
M
-
R
T
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K
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E
T
L
-
K
L
I
----
S
-
G
W
-
V
S
R
S
N
D
P
Q
M
V
A
E
N
F
V
P
P
L
L
D
A
V
L
I
D
Y
Q
R
N
V
P
A
A
E
V
L
S
T
M
A
I
I
V
N
K
------------------
L
H
--
I
------------
T
-
A
E
-
I
P
Q
I
F
D
---
A
-
V
F
E
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T
L
N
M
I
N
K
D
E
Y
P
--
E
-
H
-
R
T
N
F
F
L
L
L
Q
A
V
N
S
H
C
F
P
P
T
Q
F
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L
D
S
I
I
W
A
F
K
HTMRNVA
D
T
G
L
Q
I
L
F
T
L
L
Q
N
VAQEEAAAQSFYQTY
F
C
D
I
L
Q
H
I
F
SVVTNLVEEGKL
Q
E
Y
V
A
NP
A
F
K
E
H
L
R
D-----
26
Fugue
66.02
17%
-95
- C3 -
4LZ6
-
?
A:
[1-446]
------------------------------------------------------------------------------------
Q
K
Q
Q
S
E
R
L
G
T
E
A
I
P
K
----------------------------
L
L
R
S
L
S
I
P
A
M
I
G
M
F
V
------
M
A
L
Y
N
V
V
D
T
I
F
I
S
Y
A
V
G
I
E
G
V
A
--
G
V
T
-
I
A
F
P
I
M
M
I
M
M
S
-
M
A
G
A
---
L
G
I
G
G
A
S
V
I
S
R
-----
R
L
GER
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
L
V
L
S
V
I
G
F
I
S
A
F
T
L
L
G
P
A
L
Q
--------
L
F
G
A
T
--
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
----
L
L
G
------------------------------------------------------------------
S
I
F
F
--
F
F
A
F
A
A
N
N
I
I
R
-------
S
E
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
--------
I
F
G
L
N
M
G
V
L
G
A
S
I
---------
A
T
V
I
A
Q
A
S
V
T
---------------
G
L
V
L
R
Y
F
L
-
T
--------
G
KS
T
L
S
---
L
H
W
S
-
D
----
L
R
M
K
G
S
V
I
K
E
V
C
---------------------
L
-------
V
G
L
P
----
A
F
V
--------
Q
Q
S
S
A
S
-----
L
M
M
I
A
I
N
S
----
M
L
L
R
----
F
G
S
D
F
Y
--------------------------------------------
V
------
G
V
F
G
L
V
Q
R
I
M
M
-
F
---------
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
------
Y
G
A
K
Q
Y
-----------
S
R
L
R
E
T
V
M
-------
L
------------
G
F
K
V
A
T
I
F
-----------------------------------------------------------------------------------------
S
I
G
I
F
------
A
L
L
M
L
-----
F
P
E
A
L
L
R
V
F
T
A
D
R
E
V
I
Q
A
G
V
S
A
M
----
H
I
L
F
---
C
V
T
F
L
I
G
A
Q
I
V
A
G
G
L
Y
-----------------------------------------------------
Q
S
L
-
G
K
P
K
Q
A
L
I
L
S
L
S
R
Q
I
I
F
L
I
P
L
V
L
I
L
P
H
I
F
G
------------------
L
S
--
G
------------
V
-
W
W
-
A
F
P
I
A
D
---
V
L
S
F
I
L
T
V
V
L
L
Y
-------
R
-
D
-
R
N
V
F
F
L
K
------------------------------------------------------------------------------------------------------
27
Fugue
63.30
11%
-108
- C1 -
2A73
1
?
B:
[1-991]
VQLTEKRMDKVGKYPKEL
R
K
C
C
E
D
G
M
RENPMRFSCQRRTRFISLG
E
A
C
K
K
V
F
L
D
C
C
N
Y
I
T
E
L
R
R
Q
H
A
R
AL
D
E
D
I
I
AEEN
I
V
S
R
S
E
F
P
E
S
W
L
W
N
V
E
D
L
K
E
-------
P
P
K
N
G
I
S
T
K
L
M
N
I
F
L
K
D
S
I
T
T
W
E
I
L
A
V
S
M
S
D
K
K
G
I
C
------
V
A
D
P
F
E
V
T
V
M
Q
D
F
F
I
D
L
R
L
P
Y
S
--
V
V
R
N
E
Q
V
E
I
R
A
V
L
Y
N
-
Y
R
Q
N
---
Q
E
L
K
V
R
V
E
L
L
H
N
PAFC
S
L
---
A
T
T
K
R
R
H
Q
Q
T
V
T
I
P
P
K
S
S
L
S
V
P
Y
V
I
V
P
L
K
T
G
L
Q
E
V
E
--------
V
K
A
A
V
Y
H
H
F
I
S
D
G
V
R
K
S
L
K
V
V
----
P
E
G
I
R
M
--
N
K
--
T
V
A
V
R
T
L
D
P
E
R
L
G
R
E
G
V
Q
-------
K
---
E
D
I
P
P
A
DLSDQVPD
T
E
S
E
T
R
I
L
L
Q
G
T
P
V
A
Q
M
T
--
E
D
A
V
D
A
E
R
L
K
H
LIVTPSG
C
G
E
Q
N
M
I
G
M
T
P
T
V
I
A
V
H
Y
L
D
E
T
E
Q
W
E
K
F
G
--
L
E
K
R
Q
G
A
L
E
L
I
K
K
G
Y
T
------
Q
Q
L
A
F
R
Q
P
S
S
A
F
A
AFVKRAPS
T
W
L
T
A
Y
V
V
K
V
F
S
L
A
V
-
N
--------
L
--
I
A
I
---
D
S
Q
V
-
L
----
C
G
A
V
K
W
L
I
L
E
K
Q
KPDG
V
F
Q
E
DAPVIHQENN
N
E
K
D
-------
M
A
L
T
----
A
F
V
--------
L
I
S
L
Q
E
A
KDIC
E
E
Q
V
N
S
L
P
----
G
S
I
T
----
K
A
G
D
F
L
E
A
N
Y
M
N
L
Q
R
----------
S
Y
T
V
A
I
A
G
--------------
Y
A
L
A
Q
M
GRLK
G
P
L
L
N
K
F
L
T
T
A
-
K
DKNRWEDPG
K
Q
L
Y
N
V
-
E
A
T
S
Y
A
L
L
A
L
L
Q
L
KDFDF
V
P
P
V
V
R
W
L
N
E
QRYYG
G
G
Y
G
S
T
Q
A
T
F
-------
M
------------
V
F
Q
A
L
A
Q
Y
Q
K
D
APDHQELN
L
D
V
S
L
Q
L
PSR
S
S
K
I
T
H
R
I
H
W
E
S
A
S
-
L
L
R
S
E
E
T
KEN
E
G
F
T
V
T
A
E
G
K
G
-----
Q
G
T
L
S
V
V
T
M
Y
H
A
K
A
K
D
QLTCNK
F
D
L
K
V
T
I
K
P
A
------
P
E
T
E
K
R
P
Q
D
A
K
N
T
M
I
L
E
I
C
T
R
Y
R
G
D
Q
D
A
T
M
S
I
L
----
D
I
S
M
---
M
T
G
F
A
P
D
T
D
D
L
K
Q
L
A
N
G
V
D
R
Y
I
S
K
Y
--------
E
L
D
-
K
A
F
S
D
R
N
T
-
L
I
I
----
Y
-
L
D
-
K
V
S
H
S
E
D
D
C
L
A
F
K
V
-
H
Q
Y
F
N
V
E
L
I
Q
P
G
A
V
K
V
Y
A
Y
Y
N
L
E
E
S
C
T
R
F
Y
H
P
E
KE
D
G
K
L
N
KLCRD
E
L
C
R
C
--
A
E
E
N
C
FIQKSDDK
V
-
T
L
-
E
E
R
L
D
K
---
A
C
E
P
G
V
D
Y
V
Y
K
T
R
L
V
K
V
--
Q
-
L
-
S
N
D
F
D
E
Y
I
M
A
I
E
Q
T
I
K
S
G
S
D
E
V
Q
V
G
Q
Q
R
T
F
I
S
P
IKCREALKLEEK
K
H
Y
L
M
W
G
L
SSDFWGEKP
N
L
S
Y
I
IGKD
T
W
V
E
H
W
P
E
EDECQDEEN
Q
K
Q
C
Q
D
L
G
A
F
T
E
S
M
VVFGCPN
9
HHSearch
58.46
15%
-113
- C5 -
1TH8
-
SP2AA_GEOSE
B:
[8-114]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
Q
D
V
L
I
V
----
R
L
S
G
---
E
L
D
H
H
T
A
E
E
L
R
E
Q
V
T
D
V
L
E
------------------------------------------------------
N
R
A
I
R
H
I
V
L
N
L
G
Q
L
T
F
M
D
S
S
G
L
G
V
I
L
G
R
Y
K
------------------
Q
I
--
K
------------
N
-
V
G
-
G
Q
M
V
V
C
---
A
V
S
P
A
V
K
R
L
F
D
M
S
G
L
F
-----
K
-
I
I
R
V
E
A
D
E
Q
F
A
L
Q
A
L
G
V
A
-------------------------------------------------------------------------------------------
3
HHSearch
57.85
13%
-112
- C5 -
3QE7
2
URAA_ECOLI
A:
[12-410]
----------------------------------------------------------------------------------------------------------------------------------
P
P
L
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
L
V
P
V
L
F
H
------
I
N
P
A
T
--
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
---
P
A
Y
L
G
S
S
F
A
F
I
-----
S
P
---
V
L
L
L
L
P
--------------------------
L
G
Y
E
--------
V
A
L
G
G
--
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
D
--
V
L
--
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
-------
G
---
V
A
A
G
M
A
----------
G
L
L
P
--
A
-
E
G
-----------------
Q
T
-------
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
-------
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
------
A
L
S
F
A
M
G
I
V
---
D
---------------
T
T
P
I
I
N
A
H
W
F
--------
A
--
L
P
T
---
L
Y
T
P
-
R
----
F
E
--
W
F
A
I
L
T
I
L
---------------------
P
-------
A
A
L
V
----
V
I
A
--------
E
H
V
G
H
L
-----
V
V
T
A
N
I
V
K
KDLL
R
D
P
G
----
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
----------
G
F
F
G
S
T
P
N
--------------
T
T
Y
G
------
E
N
I
G
V
M
A
I
T
R
V
-
Y
---------
S
T
W
V
I
G
-
G
A
A
I
F
A
I
L
L
S
C
V
G
K
----
L
A
A
A
I
Q
M
I
-------
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
------------
S
G
I
R
V
L
I
E
S
K
---------------------
V
D
Y
N
--
K
A
Q
N
L
I
-
L
T
S
V
I
L
I
-----
I
G
V
S
GAKVNIGAAE
L
K
G
M
A
L
A
T
I
V
G
I
G
---------
L
S
L
I
F
K
L
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
57.61
16%
-128
- C5 -
3T6O
-
?
A:
[10-120]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
A
Q
V
T
V
I
----
S
F
P
A
VFQ
R
L
R
E
T
E
V
E
Q
I
A
S
T
F
L
A
A
M
Q
------------------------------------------------------
G
A
Q
P
R
K
V
L
I
D
L
E
G
V
E
F
F
G
S
S
F
I
E
L
L
V
R
G
W
K
------------------
R
I
--
K
------------
E
D
Q
Q
-
G
V
F
A
L
C
---
S
V
S
P
Y
C
V
E
V
L
Q
V
T
H
I
D
-----
E
-
V
W
P
R
Y
S
T
K
Q
E
A
L
L
A
M
A
---------------------------------------------------------------------------------------------
8
HHSearch
57.23
18%
-114
- C5 -
3NY7
2
?
A:
[13-118]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
P
D
D
V
L
V
L
----
R
V
I
G
---
P
L
F
F
A
A
A
E
G
L
F
T
D
L
E
S
R
L
--------------------------------------------------------
E
G
K
R
I
V
I
L
K
W
D
A
V
P
V
L
D
A
G
G
L
D
A
F
Q
R
F
V
K
------------------
R
L
--
P
--------------
E
G
-
C
E
L
R
V
C
---
N
V
E
F
Q
P
L
R
T
M
A
R
A
G
I
Q
P
--
I
P
G
-
R
L
A
F
F
P
N
R
R
A
A
M
A
D
L
----------------------------------------------------------------------------------------------
7
HHSearch
56.22
13%
-101
- C5 -
1H4X
1
SP2AA_LYSSH
A:
[8-112]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
E
T
V
V
I
----
R
L
F
G
---
E
L
D
H
H
A
V
E
Q
I
R
A
K
I
S
T
A
I
F
------------------------------------------------------
Q
G
A
V
T
T
I
I
W
N
F
E
R
L
S
F
M
D
S
S
G
V
G
L
V
L
G
R
M
R
------------------
E
L
--
E
------------
A
-
V
A
-
G
R
T
I
L
L
---
N
P
S
P
T
M
R
K
V
F
Q
F
S
G
L
G
-----
P
-
W
M
-
M
D
A
T
E
E
E
A
I
D
R
V
R
---------------------------------------------------------------------------------------------
24
Fugue
55.22
12%
-71
- C4 -
1B0P
3
POR_DESAF
A:
[785-1231]
-------------------------------------------------------------------------------
V
K
S
E
V
L
P
R
D
S
L
K
G
S
Q
F
Q
E
P
L
-------
M
E
-------------------------
F
S
G
A
C
S
G
C
-----------------------
G
E
T
P
Y
V
--
R
V
I
T
Q
L
F
G
E
R
M
F
I
A
N
-
A
T
G
C
---
S
S
I
W
G
A
S
A
P
S
M
-----
P
Y
---
K
T
N
R
L
G
Q
G
P
A
W
G
N
S
L
F
E
D
A
A
E
Y
G
F
G
M
N
M
S
M
F
A
R
R
T
H
--------
L
A
D
L
A
--
A
K
A
L
E
S
D
A
S
G
D
V
K
E
----
A
L
Q
G
W
L
--
A
G
--
K
N
D
P
I
K
S
K
E
Y
G
D
K
L
K
K
L
L
-------
A
GQK
D
G
L
L
G
Q
----------
I
A
A
M
S
D
L
Y
T
K
K
S
V
W
I
F
--
G
G
D
G
W
A
Y
D
I
G
Y
-------
G
G
L
D
H
V
L
A
S
G
E
D
V
N
V
F
V
M
D
T
E
V
----------------------------------
Y
S
N
T
G
G
Q
S
S
K
---------------
A
T
P
T
G
A
V
A
-
K
--------
F
--
A
A
A
G--
K
R
T
G
-
K
----
K
D
L
A
R
M
V
M
T
Y
G
---------------------------------
Y
----
V
Y
V
--------
A
T
V
S
M
G
-----------------
Y
S
K
Q
----
Q
F
L
K
V
L
K
E
A
E
S
F
P
G
P
----------
S
L
V
I
A
Y
A
T
--------------
C
I
N
Q
------
G
L
R
K
G
M
G
K
S
Q
D
-
V
---------
M
N
T
A
V
K
-
S
--------------------------------------------------------------------------------------------------------
G
-
Y
W
P
---------------------------------------------------------------
L
F
R
Y
D
P
R
L
A
A
Q
G
K
N
P
F
Q
L
D
S
K
A
P
D
G
S
V
E
E
F
L
----
M
A
Q
N
---
R
F
A
V
L
D
R
S
F
P
E
D
A
K
R
L
R
A
Q
V
A
H
E
L
D
--------
V
R
F
-
K
E
L
E
H
M
A
A
-
T
N
I
----
F
-
E
S
-
F
A
P
A
G
G
K
A
D
G
S
V
D
---------------------
F
G
E
G
A
E
F
C
T
R
D
------------------
D
T
--
P
------------
M
-
M
A
-
R
P
D
S
G
E
---
A
C
--------------
D
--
Q
-
N
-
R
A
-------------
G
T
S
E
Q
Q
G
D
L
S
K
R
T
K
K
-------------------------------------------------------------------------------
6
HHSearch
54.61
13%
-106
- C5 -
2KA5
-
Y1081_THEMA
A:
[14-124]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
Y
K
I
V
D
D
V
V
I
L
----
M
P
N
K
---
E
L
N
I
E
N
A
H
L
F
K
K
W
V
F
D
E
F
L
------------------------------------------------------
N
K
G
Y
N
K
I
F
L
V
L
S
D
V
E
S
I
D
S
F
S
L
G
V
I
V
N
I
L
K
------------------
S
I
--
S
------------
S
-
S
G
-
G
F
F
A
L
V
---
S
P
N
E
K
V
E
R
V
L
S
L
T
N
L
D
-----
R
-
I
V
K
I
Y
D
T
I
S
E
A
M
E
E
V
R
R
K
-------------------------------------------------------------------------------------------
10
HHSearch
53.95
19%
-87
- C5 -
1SBO
-
Y1442_THEMA
A:
[9-110]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
Q
D
D
K
A
I
V
----
R
V
Q
G
---
D
I
D
A
Y
N
S
S
E
L
K
E
Q
L
R
N
F
I
S
------------------------------------------------------
T
T
S
K
K
K
I
V
L
D
L
S
S
V
S
Y
M
D
S
A
G
L
G
T
L
V
V
I
L
K
------------------
D
A
--
K
------------
I
-
N
G
-
K
E
F
I
L
S
---
S
L
K
E
S
I
S
R
I
L
K
L
T
H
L
D
-----
K
-
I
F
K
I
T
D
T
V
E
E
A
--------------------------------------------------------------------------------------------------
5
HHSearch
53.95
14%
-72
- C5 -
2KLN
-
?
A:
[1-124]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
V
P
G
L
V
V
Y
----
R
Y
D
A
---
P
L
C
F
A
N
A
E
D
F
R
R
R
A
L
T
V
V
D
-----------------------
Q
----------------------------
D
-
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
D
L
T
A
L
D
A
L
D
Q
L
R
T
------------------
E
L
--
L
------------
R
-
R
G
-
I
V
F
A
M
A
---
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
L
D
--
K
I
G
-
E
D
H
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
-------------------------------------------------------------------------------------------
19
Fugue
51.77
16%
-62
* C5 *
3LLO
1
A:
[1-143]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Y
T
V
L
G
Q
L
P
D
T
D
V
Y
I
D
--------
I
D
A
-
Y
E
E
V
K
E
I
P
-
G
I
K
----
I
-
F
Q
-
I
N
A
P
I
Y
Y
A
N
S
D
L
Y
S
-
S
A
N
I
H
T
V
I
L
D
F
T
Q
V
N
F
M
D
S
V
G
V
K
T
L
A
G
I
V
K
------------------
E
Y
--
G
------------
D
-
V
G
-
I
Y
V
Y
L
A
---
G
C
S
A
Q
V
V
N
D
L
T
S
N
R
F
F
E
NP
A
-
L
-
K
E
L
L
F
H
S
I
H
D
A
V
L
G
S
Q
V
R
E
A
-----------------------------------------------------------------------------------------
14
HHSearch
49.26
12%
-81
- C5 -
2OOK
5
?
A:
[18-126]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
F
F
V
T
L
----
K
A
I
G
---
T
L
T
H
E
D
Y
L
V
I
T
P
M
L
E
G
A
L
S
---------------------------------------------------
Q
V
-
D
Q
P
K
V
S
L
F
L
D
A
T
E
L
D
G
W
D
L
R
A
A
--
W
D
D
L
K
L
------------------
G
L
KH
K
------------
S
-
E
F
-
E
R
V
A
I
L
---
G
N
K
D
W
Q
E
W
A
A
K
I
G
S
W
F
I
--
A
-
G
-
E
I
K
Y
F
E
D
E
D
D
A
L
K
W
L
R
Y
--------------------------------------------------------------------------------------------
20
Fugue
45.04
11%
-12
- C5 -
2KLN
-
?
A:
[1-124]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
--------
V
P
G
-
L
V
V
Y
R
Y
D
A
-
P
L
C
----
F
A
N
A
-
E
D
F
R
R
R
A
L
T
V
V
D
Q
D
-
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
D
L
T
A
L
D
A
L
D
Q
L
R
T
------------------
E
L
--
L
------------
R
-
R
G
-
I
V
F
A
M
A
---
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
L
D
--
K
-
I
G
E
D
H
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
-------------------------------------------------------------------------------------------
16
HHSearch
44.62
10%
-61
- C5 -
2Q3L
4
?
A:
[18-126]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
F
Y
L
A
F
----
K
A
V
G
---
K
L
T
H
E
D
Y
E
Q
M
T
P
L
L
E
S
A
L
A
---------------------------------------------------
G
I
-
K
T
P
E
I
V
A
L
I
D
I
T
E
L
D
G
L
S
L
H
A
A
--
W
D
D
L
K
L
------------------
G
L
--
K
H-----------
G
-
K
E
F
K
R
V
A
I
I
---
G
Q
G
E
L
Q
E
W
A
T
R
V
A
N
W
F
T
--
P
-
G
-
E
F
K
F
F
E
D
K
R
D
A
L
D
W
L
C
---------------------------------------------------------------------------------------------
1
PsiBlast_PDB
44.13
27%
-58
- C5 -
5DA0
2
?
A:
[202-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
T
L
P
-
T
--------
A
--
L
P
H
FQF
P
Q
V
P
L
T
----
F
E
T
L
A
I
I
F
P
V
A
L
---------------------
T
-------
L
S
L
V
----
G
L
L
--------
E
S
L
L
T
A
-----
Q
L
I
D
E
R
T
D
----
T
T
S
D
----
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
----------
G
F
F
G
G
M
A
G
--------------
C
A
M
I
------
G
Q
S
M
I
N
V
T
S
G
G
-
R
---------
G
R
L
S
T
F
-
V
A
G
A
F
L
M
V
L
I
L
A
------
L
Q
P
L
L
V
Q
I
-------
P
M
A
A
L
V
A
V
M
M
-------
V
------------
V
A
I
S
T
F
D
W
G
S
-------------------
L
R
F
P
K
G
E
T
V
V
M
L
A
T
-
V
A
V
T
V
F
T
-----
H
D
L
-----------
S
L
G
V
L
I
G
V
V
L
S
A
L
---------
F
F
A
R
K
V
S
Q
L
S
------
Q
V
T
P
V
D
E
V
D
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
D
----
F
T
H
P
---
A
R
R
V
V
I
D
L
S
D
A
H
F
W
D
G
S
A
V
G
A
L
D
K
V
--------
M
L
K
-
F
M
R
Q
G
T
S
V
-
E
L
R
----
G
-
L
N
-
A
A
S
A
T
L
V
E
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
38.79
24%
-74
- C5 -
4R1I
-
?
A:
[388-494]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
G
--------
L
A
G
S
V
--
L
F
I
G
F
I
L
I
C
A
F
I
N
L
----
M
I
G
S
A
S
A
Q
W
A
--
V
T
A
P
I
F
V
P
M
L
M
L
A
G
Y
A
P
E
-------
V
---
I
Q
A
A
Y
R
----------
I
G
D
S
V
T
N
I
I
T
P
M
M
S
Y
F
G
L
I
M
A
T
V
M
K
Y
K
K
D
-------
A
G
V
G
T
L
I
S
M
M
L
P
Y
S
A
F
F
L
I
A
W
I
A
L
F
C
I
W
V
--
F
V
L
G
L
P
V
G
P
G
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
35.44
9%
-22
- C5 -
3AGD
-
?
A:
[323-446]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
D
R
V
F
L
----
H
L
Q
G
---
V
I
R
F
G
G
A
E
A
V
L
D
A
L
T
D
L
R
T
---
G
W
D
--------
A
A
V
Y
P
R
W
Q
E
A
A
A
D
R
A
A
L
S
A
A
T
-
G
G
G
A
V
H
E
A
A
A
A
A
A
---
N
-
D
G
P
I
R
T
V
V
L
N
L
A
R
V
D
R
I
D
D
V
G
R
R
L
I
A
E
G
V
R
------------------
R
L
--
Q
------------
A
-
D
G
-
V
R
V
E
V
E
---
D
P
E
R
I
L
P
L
----------------------------------------------------------------------------------------------------------------------------