@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S28A1_HUMAN: (2015-12-10 )
MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ
Atome Classification :
(20 SA)
-----------------------------........-.10........20-........30-..-..---...--.40........50........60........70.....--...---80-----.......-..-90........100.------.......110........120.......130------........140.......150.......160-----.......170.......------.180......-.190--........----------200.......210-.......220....-...230.......240.--......250.-...----...--260----..----------......----.270.......280......-.290......-.300--.........310.....--..320.......330.-.....----.340.......350-...-----..-..360.......370...--....380.......390.......400......--.410.......420.....-..----430.......--------440.-----....-..450.......460------.........470.......480......-.490.......500.......510-------------........---520.......--.--------530.-......540-........550-........560....-..-.570----.-..-..---------....580.......590-----........600.-...-...610-----------.......620.......630.......640.......----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------MEN
D
P
S
R
R-RESISL
T
P
V
A
K
G
L
-
E
N
M
G
A
D
F
L
E
S
-
L
E
-EG---QLP--RSDL
S
P
A
E
I
R
S
S
W
S
EAAPK
P
F
S
R
W
RNL
Q
P
A
L
R
A
R
S
F
C
R
--
E
H
M
---
Q
------
L
F
R
W
I
G
T
-
G
L
-
L
C
T
G
L
S
A
F
L
L
V
A
-
C
------
L
L
D
F
Q
R
A
L
A
-
L
F
V
L
T
C
V
V
L
T
F
L
G
H
R
L
L
K
R
L
-------
L
G
P
K
L
R
R
F
LKPQGH
P
R
L
L
L
W
F
KR
G
L
A
L
A
A
F
L
-----
G
L
V
L
W
LSL-DTSQ
R
P
E
Q
------
L
V
S
F
A
G
I
C
V
F
-
V
A
L
---
L
F
A
CSKH
H
----------
C
A
V
S
W
R
AVSWG
L
G
-
L
Q
F
V
L
G
L
L
V
I
RTEP-GF
I
A
F
E
W
L
G
E
Q
I
R
I
F
L
S
--YTKAGSSF
V
F
-
G
E
A
----
L
V
K
--
D
------
V
F
----------
A
F
Q
V
L
P
----
I
I
V
F
F
S
C
V
I
S
V
L
Y
H
V
G
L
M
Q
W
-
V
I
L
K
I
A
W
L
M
Q
-VT----MGTTA
T
E
T
L
S
V
A
G
N
I
F
V
--SQTEA
P
L
L
I
R
P
Y
L
ADM-T
L
S
E
V
----
H
V
V
M
TG
G
Y
A
T
I
A
G
S
-
L
L
G
-----
A
Y
-
I
SFGI
D
A
T
S
L
I
A
A
S
V
M
A
A
--
P
C
A
L
A
L
S
K
LVYPEV
E
E
S
K
FRREEG
V
K
L
TYG
D
A
Q
--
N
L
I
E
A
ASTG
A
A
I
S
V
K
V
V
A
N
-
I
A
----
A
N
L
I
A
F
L
A
V
L
--------
D
F
I
N
-----
A
A
L
S
-
W
L
G
D
M
VDIQG
L
S
F
--------
Q
L
I
C
S
Y
I
L
R
P
V
A
F
L
M
G
VAWE
D
C
P
V
V
A
E
L
-
L
G
I
K
L
F
L
N
E
F
V
A
Y
Q
D
L
S
K
Y
K
Q
R
R
--------------LA
G
A
E
E
W
V---G
D
-
R
K
Q
W
I
S
V
--
R
--------
A
E
V
L
-
T
T
F
A
L
CGF--AN
F
S
S
I
G
I
M
L
--
G
G
L
T
S
MVPQRKS
D
F
S
-
Q
I
-
V
L
------
R
-
A
L
-
F
T
---------
G
A
C
V
S
L
V
N
A
C
M
A
G
I
L
Y------MPRGAE
V
D
C
M
S
L
-
L
N
T
-TLSSSS-----------
F
E
I
Y
Q
C
C
R
E
A
F
Q
SVNPEF
S
P
E
A
L
D
N
C
C
R
F
YNHTICAQ----------------------
23
Fugue
83.86
37%
-143
- C10 -
3TIJ
6
?
A:
[8-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
------
F
M
S
L
I
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
VS
G
K
M
F
E
--
V
FGGGGF
I
F
----------
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
K
P
Q
-----------
D
K
P
A
--
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
---------------------------
E
A
-
A
P
V
V
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.20
36%
-145
- C10 -
4PDA
2
?
A:
[8-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
------
F
M
S
C
C
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.75
36%
-145
- C10 -
4PB2
2
?
A:
[8-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
------
F
M
S
C
C
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.71
36%
-145
- C10 -
4PD6
2
?
A:
[11-419]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
C
C
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.66
36%
-145
- C10 -
4PD8
2
?
A:
[8-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
------
F
M
S
C
C
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.51
36%
-142
- C10 -
4PD9
2
?
A:
[8-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
------
F
M
S
C
C
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.49
36%
-145
- C10 -
4PB1
2
?
A:
[8-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
------
F
M
S
C
C
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.67
36%
-144
- C10 -
4PD5
2
?
A:
[9-419]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
------
F
M
S
C
C
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.65
36%
-144
- C10 -
3TIJ
6
?
A:
[8-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
------
F
M
S
L
I
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.36
36%
-145
- C10 -
4PD7
2
?
A:
[8-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
------
F
M
S
L
I
G
M
A
V
L
-
L
G
I
---
A
V
L
L
S
S
N
R
----------
K
A
I
N
L
R
T
V
G
G
A
F
A
-
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
-
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
--
Y
G
N
D
G
T
S
F
L
F
-
G
G
L
----
V
S
G
--
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
----
T
L
I
F
F
S
A
L
I
S
V
L
Y
Y
L
G
V
M
Q
W
-
V
I
R
I
L
G
G
G
L
Q
-
K
A
----
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
--
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
-
T
Q
S
E
L
----
F
A
V
M
C
G
G
L
A
S
I
A
G
G
-
V
L
A
-----
G
Y
-
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
--
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
A
L
N
-
V
G
----
A
M
L
I
A
F
I
G
L
I
--------
A
L
I
N
-----
G
M
L
G
-
G
I
G
G
W
F
G
M
P
E
L
K
L
--------
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
-
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
------------------
L
T
E
A
A
P
V
V
----------
L
S
E
--
K
--------
T
K
A
I
-
I
S
F
A
L
C
G
F
--
A
N
L
S
S
I
A
I
L
L
--
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
-
R
M
-
G
V
------
K
-
A
V
-
I
A
---------
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
---------------------------------------------------------------------------------------------------
30
Fugue
62.55
17%
-112
- C6 -
3VSM
1
OE66_NPVAC
A:
[27-659]
----------------------------------------------
N
I
Q
E
L
-
Q
N
F
E
R
W
F
K
N
N
-
L
S
-
Y
S
---
F
S
Q
--
K
A
E
-
K
V
V
N
P
N
R
N
W
N
D
N
-----
T
V
F
D
N
L
S
P
---------------------------
W
T
S
V
-
P
D
-
F
G
T
V
C
H
T
L
I
G
Y
C
-
V
------
R
Y
N
N
T
S
D
T
L
-
Y
Q
N
P
E
L
A
Y
N
L
I
N
G
L
R
I
I
C
S
K
-------
L
P
D
P
P
P
H
Q
Q
A
P
W
G
P
V
A
D
W
Y
H
F
T
I
-
T
M
P
E
V
F
M
-----
N
I
T
I
V
L
---
N
E
T
Q
H
Y
D
E
------
A
A
S
L
T
R
Y
W
L
G
-
L
Y
L
PTA
V
N
S
M
G
W
H
R
----------
T
A
----
G
N
S
M
R
M
G
-
V
P
Y
T
Y
S
Q
M
L
R
G
Y
S
L
-
A
Q
I
R
Q
E
Q
G
I
Q
E
I
L
N
T
I
A
FP
Y
V
T
Q
G
N
G
L
H
V
-
D
S
I
----
Y
I
D
HI
D
------
V
R
----------
A
Y
G
Y
L
I
----
N
S
Y
F
T
F
A
Y
Y
T
Y
Y
F
G
D
E
V
I
N
T
-
V
G
L
T
R
A
I
E
N
V
-
G
S
P---
E
G
V
V
V
P
G
V
M
S
R
N
G
T
L
Y
S
--
N
V
I
G
N
F
I
T
Y
P
L
A
V
H
S
A
-
D
Y
S
K
V
----
L
T
K
L
S
K
---
T
Y
Y
G
S
-
V
V
G
V
T
NRL
A
Y
---
Y
E
S
D
P
T
N
N
I
Q
A
P
L
W
T
M
--
A
R
R
I
W
N
R
R
G
R
I
I
N
Y
N
A
N
T
V
S
F
E
S
G
I
I
L
Q
S
L
N
G
I
--
M
R
I
P
S
G
T
T
S
---
T
Q
S
F
R
P
T
-
I
G
----
Q
T
A
I
A
K
T
D
T
A
--------
G
A
I
L
-----
V
Y
A
K
-
F
-
A
E
M
N
N
L
Q
F
K
S
C
--------
T
L
F
Y
D
H
G
M
F
Q
L
Y
Y
N
I
G
V
E
P
N
S
L
N
N
-
T
N
G
-
R
V
I
V
L
S
R
D
T
S
V
N
T
N
D
L
S
F
E
A
Q
R
I
N
N
NNSSEGTTFNG
V
V
C
H
R
V
P
I
T
---
N
I
-
N
V
P
S
L
T
V
--
R
S
PNSS
V
E
L
V
E
Q
I
-
I
S
F
Q
T
M
Y
T
--
A
T
A
S
A
C
Y
K
L
N
VE
G
H
S
D
S
L
R
A
F
R
V
N
S
D
E
-
N
I
-
Y
V
N
VGNG
V
K
-
A
L
-
F
N
---------
Y
P
W
V
M
V
K
E
-----------------
N
N
K
V
S
F
M
S
A
N
E
D
T
-
T
I
P
-----------------
F
S
V
I
M
N
S
F
T
S
I
G
E
P
A
L
Q
Y
S
P
S
N
C
F
V
Y
G
N
G
F
K
L
N
N
STF
D
L
Q
F
I
F
E
I
V----------
31
Fugue
50.83
13%
-110
- C7 -
3KX2
1
PRP43_YEAST
A:
[1-755]
MGSK
R
R
F
S
SEHPDPVETS
I
P
E
Q
A
A
E
I
A
E
E
L
S
K
Q
H
P
L
P
-
S
E
E
P
L
V
H
H
D
A
G
E
F
-
K
G
L
Q
R
H
H
T
S
A
-
E
E
-
A
Q
---
K
L
E
--
D
G
K
I
N
P
F
T
G
R
E
F
T
P
K
Y
V
D
I
L
K
I
R
-
R
E
L
-
P
V
H
A
Q
R
D
E
F
L
--
K
L
Y
---
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
-
G
--
K
T
T
Q
I
P
Q
F
V
L
F
D
E
M
------
P
H
L
E
N
T
Q
V
A
-
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
E
E
M
DVKLGEE
V
G
Y
S
I
R
-
F
E
N
K
T
S
N
K
T
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
E
D
H
DL
S
R
Y
S
C
I
I
L
-
D
E
A
H
E
R
T
-----------
L
A
T
D
I
L
-
M
G
L
---
L
K
Q
V
V
K
R
R
----------
P
D
L
K
I
I
I
M
S
A
T
L
D
-
A
E
K
F
Q
R
Y
F
-----
N
-
D
A
P
L
L
A
V
P
G
R
T
Y
P
V
E
L
Y
--
Y
T
P
E
F
Q
R
D
-
Y
-
L
D
S
----
A
I
R
--
T
------
V
L
----------
Q
I
H
A
T
E
E
A
G
D
I
L
L
F
L
T
G
E
D
E
I
E
D
A
V
R
K
I
S
L
-
E
G
D
Q
L
V
R
E
E
---------
G
C
G
P
L
S
V
Y
P
L
Y
G
S
L
P
---
P
H
Q
Q
Q
R
I
F
E
P
A
P
E
S
H
N
-
G
R
P
G
R
----
K
V
V
I
S
T
N
I
A
E
T
S
L
T
-
I
D
G
--------
I
V
Y
V
V
D
P
-
G
F
S
K
Q
K
V
Y
N
P
--
R
I
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
--
R
L
Y
T
E
E
A
F
Q
K
E
L
I
E
Q
S
Y
P
E
-
I
L
RSNL
S
S
T
V
L
E
L
K
K
L
GIDDLVHF
D
F
M
D
PPA
P
E
T
M
M
R
-
A
L
E
E
L
N
Y
L
A
C
L
D
D
EGNLT
P
L
G
R
L
A
S
Q
F
P
L
D
P
M
L
A
V
M
L
I
G
S
F
E
F
Q
C
S
Q
E
I
-
L
T
I
V
A
M
L
S
V
P
N
V
F
I
R
P
T
K
D
K
K
R
A
--------------
D
D
A
K
N
I
F
A
H
P
D
G
D
-
H
I
T
L
L
N
V
--
Y
--------
H
A
F
K
S
D
E
A
Y
E
Y
G
I
--
H
K
W
C
R
D
H
Y
L
N
--
Y
R
S
L
S
A
A
D
N
I
R
S
Q
L
E
-
R
L
-
M
N
------
R
-
Y
N
-
L
E
L
N
T
T
DYESP
K
Y
F
D
N
I
R
K
A
L
A
S
G
F
F
M
Q
V
A
K
K
R
S
G
A
K
G
Y
I
T
V
K
D
N
-
Q
D
V
-
L
I
H
P
S
T
V
L
G
HDAE
W
V
I
Y
N
E
F
V
L
T
S
K
N
Y
I
R
T
V
T
S
V
R
P
E
W
L
I
E
I
A
P
A
Y
Y
D
L
S
N
F
Q
K
GDV
K
L
S
L
E
R
I
K
E
K
V
D
R
L
N
E
L
K
Q
24
Fugue
50.32
14%
-62
- C10 -
4U3E
3
?
A:
[12-670]
------------------------------
S
G
L
V
G
S
H
M
K
V
Q
Y
S
F
E
R
E
F
E
E
L
M
S
D
L
L
S
K
Y
G
Y
E
M
F
Q
M
D
G
LGD
Q
L
D
--
V
V
K
F
T
E
D
F
V
R
R
G
I
I
E
S
T
I
D
A
N
A
N
V
R
V
T
N
I
S
T
Y
F
I
E
I
S
K
--
P
H
T
Y
L
Y
S
------
L
Y
R
I
W
Q
K
M
K
E
M
F
G
K
G
V
A
D
E
F
V
E
A
-
Q
I
N
GA
V
Y
L
H
D
R
H
H
A
A
L
M
P
Y
---
C
F
A
Y
T
L
--
K
P
I
V
E
K
G
-------
L
P
F
I
K
T
I
K
S
E
P
A
K
H
------------
L
S
T
F
I
-----
Q
H
V
I
Q
F
-
V
M
F
A
S
N
Q
S
S
G
------
A
V
G
L
P
D
F
F
V
W
M
W
Y
F
---
V
K
K
D
L
K
E
G
-----------
I
I
P
R
D
K
L
D
W
Y
I
E
-
Q
H
F
Q
I
L
T
Y
S
-------------
L
N
Q
P
I
R
T
T
Q
S
-----
P
Y
T
N
F
T
Y
L
D
R
N
----
Y
I
K
--
A
------
I
F
----------
E
G
E
R
Y
P
----
D
G
S
L
I
T
D
H
V
E
D
I
I
A
L
Q
K
H
Y
W
-
E
W
V
S
R
E
R
E
R
Q
M
F
T
----
F
-
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
L
--
D
E
D
S
A
R
F
I
N
K
I
----
N
M
K
W
Q
D
T
----
N
W
Y
I
S
D
S
I
D
A
V
A
S
C
E
K
L
K
-----
G
R
M
N
S
I
G
G
S
D
L
N
I
G
S
F
K
V
I
T
V
N
L
P
R
I
A
L
E
S
G
G
D
R
E
K
Y
L
Q
I
L
R
H
R
V
Q
L
I
K
K
A
L
A
A
V
R
--
E
I
I
K
E
R
I
S
E
G
L
L
P
L
Y
E
N
G
L
M
L
L
----
N
R
Q
Y
G
T
I
G
V
T
--------
G
V
W
E
-----
S
A
S
I
M
G
L
-
T
T
E
D
I
D
G
L
K
Y
--------
T
E
E
G
E
V
F
V
D
N
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
Y
G
F
T
F
N
I
E
Q
V
P
A
E
K
A
A
V
T
L
A
Q
K
--
D
R
F
--------------
L
F
G
E
K
Q
P
F
---
E
I
Y
S
N
Q
W
V
P
L
MA
N
--------
T
D
V
L
-
N
R
I
R
Y
S
G
K
W
D
K
K
V
S
G
G
A
I
L
H
--
I
N
L
G
E
S
F
K
T
E
E
E
S
F
N
M
V
K
M
I
A
------
D
M
G
V
M
Y
F
---------
A
F
N
T
K
I
S
V
C
E
D
G
H
A
F
Y
------
G
E
R
C
P
V
C
G
K
A
K
V
-
D
E
Y
M
R
I
V
G
Y
L
-----------
V
P
V
S
A
F
N
K
E
R
R
E
I
E
Y
P
R
----------
R
Q
F
Y
D
S
L
T
I
R
----------------------
29
Fugue
45.11
21%
-139
- C5 -
4MFL
4
?
A:
[23-345]
-----------------------------------------------------------------------------
M
D
P
E
T
V
R
I
A
L
G
L
E
E
R
T
A
A
W
L
T
E
L
D
E
L
G
P
P
A
E
P
V
R
L
P
R
G
E
E
A
R
---
D
------
L
L
R
R
L
E
------
V
P
E
L
D
A
E
E
I
V
A
-
A
------
A
P
D
P
D
R
D
P
A
-
L
W
W
L
L
E
R
T
-----
H
H
A
I
V
R
H
-------
M
G
D
H
R
---
A
K
P
R
G
G
P
P
L
P
--
Y
E
G
G
A
A
A
R
Y
F
H
-----
V
Y
V
F
L
A
T
V
-
P
A
V
R
R
F
H
A
E
R
GIP
D
E
V
G
W
E
T
L
T
Q
L
-
G
E
L
---
V
A
I
H
R
R
K
Y
G
Q
G
G
M
NMQWW
T
T
Y
H
L
R
G
I
L
Y
R
L
G
R
L
Q
F
S
L
A
T
G
K
D
G
T
P
H
L
G
L
A
V
P
E
W
G
G
P
-----
L
L
--
P
K
A
Y
D
E
S
L
H
R
-
A
R
P
----
F
F
D
--
R
------
H
F
----------
P
E
H
G
A
R
----
V
A
W
G
S
S
W
M
L
D
P
Q
L
E
E
Y
L
T
E
D
S
N
I
I
Q
L
A
R
F
W
T
-
L
T
DSAP
E
P
G
N
A
D
G
D
S
S
I
L
E
F
V
F
R
YN
G
Q
P
L
D
E
L
P
Q
R
S
S
L
E
R
A
-
V
I
A
H
L
K
A
G
R
H
W
H
M
R
T
G
F
V
K
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
35.18
18%
-83
- C9 -
1GPQ
-
IVY_ECOLI
A:
[2-128]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
L
T
I
S
S
L
A
K
G
E
T
T
K
A
A
F
N
Q
M
V
Q
G
H
K
L
P
A
-----------
W
V
M
K
-
G
G
T
Y
T
P
A
Q
------
T
V
T
L
G
D
E
T
Y
Q
-
V
M
S
---
A
--
C
K
P
H
D
----------
C
G
S
Q
R
I
A
V
M
W
S
E
K
-
S
N
Q
M
T
G
L
F
S
T
I
D
E
K
T
S
Q
E
K
L
T
W
L
N
V
N
D
A
L
S
I
D
--
G
K
T
V
L
F
A
A
L
T
-
G
-
S
----
L
E
N
--
H
------
P
D
----------
G
F
N
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
30.63
28%
-81
- C10 -
1KQG
3
FDNG_ECOLI
A:
[78-187]
-----------------------------
I
E
G
D
P
D
H
P
-
V
S
R
G
A
L
C
P
K
G
A
G
L
-----
L
D
Y
V
N
S
-
E
N
-
R
L
---
R
Y
P
E
Y
R
A
P
G
S
D
K
W
Q
R
I
S
W
E
E
A
----
F
S
R
I
A
K
L
M
K
A
D
R
D
A
N
F
I
E
--
K
N
E
---
Q
GVT---
V
N
R
W
L
S
T
-
G
M
-
L
C
A
S
G
A
S
N
E
T
G
M
-
L
------
T
Q
K
F
A
R
S
L
G
-
M
L
A
V
D
N
Q
A
R
V
C
S
E
H
G
P
T
V
A
S
-------
L
A
P
T
F
G
R
G
A
M
T
N
H
W
V
D
I
K
N
A
N
V
V
M
V
M
G
G
N
A
A
-----
E
A
H
P
V
G
F
R
-
W
A
M
E
A
K
N
N
------
N
D
A
T
L
I
V
V
D
P
-
R
F
T
---
R
T
A
S
V
A
D
I
----------
Y
A
P
I
R
S
G
T
D
I
T
F
L
-
S
G
V
L
R
Y
L
I
E
N
N
K
I
N
-
A
E
Y
V
K
H
Y
T
N
A
S
L
L
V
R
D
D
--
F
A
F
E
D
G
L
F
S
G
-
Y
D
A
----
E
K
R
--
Q
------
Y
D
----------
K
S
S
W
N
Y
----
Q
L
D
E
N
G
Y
A
K
R
D
E
T
L
T
H
P
R
C
V
-
W
N
L
L
K
E
H
V
S
R
-
Y
T
----
P
D
V
V
E
N
I
C
G
T
P
K
A
D
F
L
K
--
V
C
E
V
L
A
S
T
S
A
P
D
R
T
T
T
-
F
L
Y
A
L
----
G
W
T
Q
H
T
V
G
A
Q
N
I
R
T
-
M
A
M
-----
I
Q
-
L
L
L
G
N
M
G
M
A
G
G
G
V
N
A
L
R
G
--
H
S
N
I
Q
G
L
T
D
L
G
L
L
S
T
S
L
P
G
Y
L
T
L
P
S
E
K
Q
V
D
L
Q
S
--
Y
L
E
A
N
T
P
K
A
T
L
A
D
Q
V
N
Y
W
S
-
N
Y
----
P
K
F
F
V
S
L
M
K
S
--------
F
Y
G
D
-----
A
A
Q
K
-
E
N
N
W
G
Y
D
W
L
P
K
W
D
--------
Q
T
Y
D
V
I
K
Y
F
N
M
M
D
E
G
K
V
T
G
Y
F
C
Q
G
F
N
P
V
-
A
S
F
P
D
K
N
K
V
V
S
C
L
S
K
L
K
Y
M
V
V
I
D
--------------
P
L
V
T
E
T
S
T
---
F
W
-
Q
N
H
G
E
S
N
--
D
--------
V
D
P
A
-
S
I
Q
T
E
V
F
R
--
L
P
S
T
C
F
A
E
E
D
--
G
S
I
A
N
S
G
R
W
L
Q
W
H
W
K
-
G
Q
-
D
A
------
P
-
G
E
-
A
R
---------
N
D
G
E
I
L
A
G
I
Y
H
H
L
R
E
L
------
Y
Q
S
E
G
G
K
G
V
E
P
L
-
M
K
M
-
S
W
N
Y
K
Q
-----------
P
H
E
P
Q
S
D
E
V
A
K
E
N
N
G
Y
A
L
E
D
L
Y
D
A
N
G
V
L
I
A
K
K
G
Q
L
L
S
----------------------
10
PsiBlast_PDB
30.61
28%
-84
- C10 -
1KQF
3
FDNG_ECOLI
A:
[78-187]
-----------------------------
I
E
G
D
P
D
H
P
-
V
S
R
G
A
L
C
P
K
G
A
G
L
-----
L
D
Y
V
N
S
-
E
N
-
R
L
---
R
Y
P
E
Y
R
A
P
G
S
D
K
W
Q
R
I
S
W
E
E
A
----
F
S
R
I
A
K
L
M
K
A
D
R
D
A
N
F
I
E
--
K
N
E
---
Q
GVT---
V
N
R
W
L
S
T
-
G
M
-
L
C
A
S
G
A
S
N
E
T
G
M
-
L
------
T
Q
K
F
A
R
S
L
G
-
M
L
A
V
D
N
Q
A
R
V
C
S
E
H
G
P
T
V
A
S
-------
L
A
P
T
F
G
R
G
A
M
T
N
H
W
V
D
I
K
N
A
N
V
V
M
V
M
G
G
N
A
A
-----
E
A
H
P
V
G
F
R
-
W
A
M
E
A
K
N
N
------
N
D
A
T
L
I
V
V
D
P
-
R
F
T
---
R
T
A
S
V
A
D
I
----------
Y
A
P
I
R
S
G
T
D
I
T
F
L
-
S
G
V
L
R
Y
L
I
E
N
N
K
I
N
-
A
E
Y
V
K
H
Y
T
N
A
S
L
L
V
R
D
D
--
F
A
F
E
D
G
L
F
S
G
-
Y
D
A
----
E
K
R
--
Q
------
Y
D
----------
K
S
S
W
N
Y
----
Q
L
D
E
N
G
Y
A
K
R
D
E
T
L
T
H
P
R
C
V
-
W
N
L
L
K
E
H
V
S
R
-
Y
T
----
P
D
V
V
E
N
I
C
G
T
P
K
A
D
F
L
K
--
V
C
E
V
L
A
S
T
S
A
P
D
R
T
T
T
-
F
L
Y
A
L
----
G
W
T
Q
H
T
V
G
A
Q
N
I
R
T
-
M
A
M
-----
I
Q
-
L
L
L
G
N
M
G
M
A
G
G
G
V
N
A
L
R
G
--
H
S
N
I
Q
G
L
T
D
L
G
L
L
S
T
S
L
P
G
Y
L
T
L
P
S
E
K
Q
V
D
L
Q
S
--
Y
L
E
A
N
T
P
K
A
T
L
A
D
Q
V
N
Y
W
S
-
N
Y
----
P
K
F
F
V
S
L
M
K
S
--------
F
Y
G
D
-----
A
A
Q
K
-
E
N
N
W
G
Y
D
W
L
P
K
W
D
--------
Q
T
Y
D
V
I
K
Y
F
N
M
M
D
E
G
K
V
T
G
Y
F
C
Q
G
F
N
P
V
-
A
S
F
P
D
K
N
K
V
V
S
C
L
S
K
L
K
Y
M
V
V
I
D
--------------
P
L
V
T
E
T
S
T
---
F
W
-
Q
N
H
G
E
S
N
--
D
--------
V
D
P
A
-
S
I
Q
T
E
V
F
R
--
L
P
S
T
C
F
A
E
E
D
--
G
S
I
A
N
S
G
R
W
L
Q
W
H
W
K
-
G
Q
-
D
A
------
P
-
G
E
-
A
R
---------
N
D
G
E
I
L
A
G
I
Y
H
H
L
R
E
L
------
Y
Q
S
E
G
G
K
G
V
E
P
L
-
M
K
M
-
S
W
N
Y
K
Q
-----------
P
H
E
P
Q
S
D
E
V
A
K
E
N
N
G
Y
A
L
E
D
L
Y
D
A
N
G
V
L
I
A
K
K
G
Q
L
L
S
----------------------
17
HHSearch
29.38
36%
1560
- C1 -
1P1P
-
CA4A_CONPU
A:
[1-11]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
C
G
S
Y
P
N
A
A
C
H
P
----------------------
19
HHSearch
28.25
36%
2215
- C2 -
1PQR
-
CA4A_CONER
A:
[1-11]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
C
G
P
Y
-
N
A
A
C
H
C
----------------------
13
HHSearch
27.08
20%
-126
- C10 -
3RLF
1
MALF_ECOLI
F:
[14-87]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
K
W
S
V
-
L
G
L
L
G
-----
L
L
V
G
Y
L
V
V
-
L
M
Y
A
Q
G
E
Y
------
L
F
A
I
T
T
L
I
L
S
-
S
A
G
---
L
Y
I
F
A
N
-
R
----------
K
A
Y
A
W
R
Y
V
Y
P
G
M
A
-
G
M
G
L
F
V
L
F
P
L
V
C
T
I
-
A
I
A
F
T
N
Y
S
S
T
N
Q
L
T
F
E
R
--
A
Q
E
V
L
L
D
R
S
W
-
Q
A
G
----
K
T
Y
--
N
------
F
G
----------
L
Y
P
A
G
D
----
E
W
Q
L
A
L
S
D
G
E
T
G
K
N
Y
L
S
D
A
F
-
K
F
G
G
E
Q
K
L
Q
L
-
K
E
----
T
T
A
Q
P
E
G
E
R
A
N
L
R
V
I
T
Q
--
N
R
Q
A
L
S
D
I
T
A
I
L
P
D
G
N
-
K
V
M
M
S
----
S
L
R
Q
F
S
G
T
Q
P
L
Y
T
L
-
D
G
D
-----
G
T
-
L
T
N
N
Q
S
G
V
K
Y
R
P
N
N
Q
I
G
F
--
Y
Q
S
I
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
T
G
W
K
N
F
T
R
V
F
T
D
E
G
I
--
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
-
F
L
----
T
V
A
V
G
M
V
L
A
C
--------
L
V
Q
W
-----
E
A
L
R
-
G
K
A
V
Y
R
V
L
L
I
L
P
Y
--------
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
--------------
T
W
L
G
Y
P
Y
M
---
M
I
-
L
C
M
G
L
L
K
--
A
--------
I
P
D
D
-
L
Y
E
A
S
A
M
D
--
G
A
G
P
F
Q
N
F
F
K
--
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
-
A
S
-
F
A
------
F
-
N
F
-
N
N
---------
F
V
L
I
Q
L
L
T
N
G
G
P
D
R
L
G
------
T
T
T
P
A
G
Y
T
D
L
L
V
-
N
Y
T
-
Y
R
I
A
F
E
-----------
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
---------------------------------