@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S28A2_HUMAN: (2015-12-10 )
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPNTSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
Atome Classification :
(20 SA)
.........10........20........30........40........50...---....-.60........70........80-----........90........100.......110.....-..120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......-240.......----250---....------..----------..260.......270....--...280.......290.......300.......310.......320.......330.......340....---...350.......360.......370.......380.......390.......400.--......-410.......420.......430.......440.......450.......460.......470.......480.......490.......500......-.510.......-520......--.530.....---..540.......550.......560.......570.......580.......590.......600.......610.......620........630...-....640.........650......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEKASGR
Q
S
I
A
L
S
T
VETGTVNP
G
L
E
L
M
E
K
EVEPEGSKRTDAQGHSLGDGLG
P
S
T
---
Y
Q
R
R-SRWP
F
S
K
A
R
S
F
C
K
T
H
A
S
L
F
K
K
I
L
-----
L
G
L
L
C
L
A
Y
A
A
Y
L
L
A
A
C
I
L
N
F
Q
R
A
L
A
L
F
V
I
T
C
L
V
I
F
V
-
L
V
H
S
F
L
K
K
L
L
G
K
K
L
T
R
C
LKPFENS
R
L
R
L
W
T
K
W
V
F
A
G
V
S
L
V
G
L
I
L
W
L
ALDTAQR
P
E
QLI
P
F
A
G
I
C
M
F
I
L
I
L
F
A
CSKHHSA
V
S
W
R
T
V
F
SGL
G
L
Q
F
V
F
G
I
L
V
I
RTDL
G
Y
T
V
F
Q
W
L
G
E
Q
V
Q
I
F
L
N
Y
-
T
VAGS
S
F
VF
G
----
D
T
----
L
V
K
D
------
V
F
----------
A
F
Q
A
L
P
I
I
I
F
F
G
C
V
V
S
I
L
Y
--
Y
L
G
L
V
Q
W
V
V
Q
K
V
A
W
F
L
Q
I
TMGTTA
T
E
T
L
A
V
A
G
N
I
F
V
GMTEA
P
L
L
I
RPYLGDM
T
L
S
E
I
H
A
V
M
TGG
F
A
T
I
S
G
---
T
V
L
G
A
F
I
A
FGV
D
A
S
S
L
I
S
A
S
V
M
AA
P
C
A
LASSKLAYPEV
E
E
SKFKSEEGVKLPRGKER--
N
V
L
E
AA-SNGA
V
D
A
I
G
L
A
T
N
V
A
A
N
L
I
A
F
L
A
V
L
A
F
I
N
A
A
L
S
W
L
G
E
L
VDIQG
L
T
F
Q
V
I
C
S
Y
L
L
R
P
M
V
F
M
MGVEWTD
C
P
M
V
A
E
M
V
G
I
K
F
F
I
N
E
F
V
A
Y
Q
Q
L
S
Q
Y
K
N
K
R
L
S
-
G
M
E
E
W
I
EG
E
K
Q
-
W
I
S
V
R
A
E
I
I
--
T
T
F
SLCGFA---NL
S
S
I
G
I
TLG
G
L
T
S
IVPHRKS
D
L
S
K
V
V
V
R
A
L
F
T
G
A
C
V
S
L
I
S
A
C
M
A
G
I
L
YVPRGAEADCVSFPNTSFTN
R
T
Y
E
T
Y
M
C
C
R
G
L
F
Q
S-TSLNGTNPPSFSGPW-EDK
E
F
--
S
A
M
A
L
T
N
C
CGFYNNTVCA
22
Fugue
85.91
38%
-139
- C6 -
3TIJ
6
?
A:
[8-422]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
F
M
S
L
I
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
VS
G
K
M
F
E
V
FGGGGF
I
F
----------
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
K
-----------
P
Q
D
K
P
A
--
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
E
A
A
P
-
V
V
-----------
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
6
PsiBlast_PDB
84.60
37%
-135
- C6 -
4PD6
2
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
5
PsiBlast_PDB
84.20
37%
-135
- C6 -
4PD5
2
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
9
PsiBlast_PDB
84.16
37%
-136
- C6 -
4PDA
2
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
4
PsiBlast_PDB
83.95
37%
-135
- C6 -
4PB2
2
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
3
PsiBlast_PDB
83.85
37%
-135
- C6 -
4PB1
2
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
8
PsiBlast_PDB
83.79
37%
-134
- C6 -
4PD9
2
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
7
PsiBlast_PDB
83.74
37%
-135
- C6 -
4PD8
2
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
2
PsiBlast_PDB
83.62
37%
-135
- C6 -
4PD7
2
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
1
PsiBlast_PDB
83.58
37%
-135
- C6 -
3TIJ
6
?
A:
[15-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
R
K
A
I
N
L
R
T
V
G
G
A
F
A
I
Q
F
S
L
G
A
F
I
L
Y
V
P
W
G
Q
E
L
L
R
G
F
S
D
A
V
S
N
V
I
N
Y
-
G
N
D
G
T
S
F
L
F
G
----
G
L
----
V
S
G
K
------
M
F
E
V
FGGGGFIF
A
F
R
V
L
P
T
L
I
F
F
S
A
L
I
S
V
L
Y
--
Y
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
G
T
S
R
A
E
S
M
S
A
A
A
N
I
F
V
G
Q
T
E
A
P
L
V
V
R
P
F
V
P
K
M
T
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
G
---
G
V
L
A
G
Y
A
S
M
G
V
K
I
E
Y
L
V
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
M
M
P
E
T
E
--
K
P
Q
D
-----------
K
PA
N
V
I
D
A
A
-
A
G
G
A
S
A
G
L
Q
L
A
L
N
V
G
A
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
G
G
W
F
G
M
P
E
L
K
L
E
M
L
L
G
W
L
F
A
P
L
A
F
L
I
G
V
P
W
N
E
A
T
V
A
G
E
F
I
G
L
K
T
V
A
N
E
F
V
A
Y
S
Q
F
A
P
Y
L
T
-----------
E
A
A
P
V
-
V
L
S
E
K
T
K
A
I
--
I
S
F
A
L
C
G
F
A
---
N
L
S
S
I
A
I
L
L
G
G
L
G
S
L
A
P
K
R
R
G
D
I
A
R
M
G
V
K
A
V
I
A
G
T
L
S
N
L
M
A
A
T
I
A
G
F
F
L
----------------------------------------------------------------------------
31
Fugue
62.25
20%
-66
- C4 -
4PXG
-
T2S3_STAAU
A:
[26-509]
T
K
Q
A
V
H
N
R
A
K
E
A
V
G
K
S
V
L
E
L
N
G
G
--------
E
S
I
K
S
S
V
G
D
A
F
E
N
W
F
G
V
A
L
K
A
T
P
---
F
K
K
L
-
K
N
G
K
Y
S
S
K
E
R
L
V
L
N
I
I
N
-
Y
E
K
V
A
N
ENFE
T
S
S
F
L
S
K
N
N
T
I
E
L
A
F
Y
E
Y
I
K
G
T
P
S
D
N
W
I
I
K
E
A
V
L
Y
E
M
H
K
N
P
I
D
Y
E
I
I
K
Q
D
W
E
I
I
N
Q
Y
I
N
E
G
K
A
H
E
L
------------------------
S
E
G
L
T
S
Y
---------
L
A
P
C
T
K
G
A
N
A
S
S
L
R
N
Q
-------------------
P
Y
S
D
I
K
A
K
Q
R
A
F
S
L
K
S
G
Y
M
T
S
I
L
R
K
Y
V
L
G
D
E
K
I
D
S
----
I
V
K
D
------
P
F
----------
E
I
K
E
K
S
-------
I
E
D
I
V
F
E
K
F
Q
P
Y
I
N
W
S
I
D
K
L
C
E
H
F
S
I
N
K
G
E
K
-------------------------------------------------------------
G
L
N
Y
R
I
A
S
A
I
L
N
L
K
G
K
T
T
K
S
K
-
P
F
P
E
V
E
E
F
E
-
K
S
S
I
V
V
K
T
V
H
F
N
K
K
--
N
V
N
K
E
S
M
S
F
G
A
F
K
F
E
E
L
A
N
E
E
W
E
D
S
E
G
Y
P
S
A
--------
Q
W
R
N
F
L
L
E
T
R
F
L
F
F
V
V
K
E
----------------
D
E
D
G
V
D
I
F
K
G
I
K
F
F
------------------
S
M
P
E
E
D
I
N
G
P
V
K
R
M
W
D
D
T
V
K
K
L
K
--
E
----------------
G
V
T
L
E
A
V
P
D
-----
K
S
T
K
D
G
W
R
I
K
N
N
F
V
D
K
S
D
D
L
I
-----------------
C
H
V
R
P
H
T
N
--
N
R
D
Y
R
G
G
S
N
A
D
K
L
P
K
K
I
N
W
I
N
R
P
D
S
D
D
Y
S
D
E
W
M
T
K
Q
S
F
W
I
N
N
D
Y
I
K
K
Q
V
E
D
L
L
-----
18
HHSearch
32.01
55%
1514
- C1 -
1P1P
-
CA4A_CONPU
A:
[1-11]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
C
G
S
Y
P
N
A
A
C
H
11
PsiBlast_PDB
30.21
31%
174
- C6 -
4WZG
-
ATGA1_HUMAN
A:
[51-113]
-----
G
T
Q
D
V
D
C
D
F
I
D
F
T
Y
V
R
V
S
S
E
E
L
D
R
A
L
R
K
V
V
G
E
F
K
D
A
L
R
N
S
G
G
D
G
L
G
Q
M
S
L
E
F
Y
Q
K
K
K
S
R
W
P
F
S
D
E
C
I
P
W
E
V
W
T
V
K
V
H
V
V
A
-----
L
A
T
E
Q
E
R
Q
I
C
R
E
K
V
G
E
K
L
C
E
K
I
I
N
I
V
E
V
M
N
R
H
E
Y
L
P
-
K
M
P
T
Q
S
E
V
D
N
V
F
D
T
G
L
R
D
V
Q
P
Y
L
Y
K
I
S
F
Q
I
T
D
A
L
G
T
S
V
T
T
T
M
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
29.96
16%
28
- C6 -
2A10
-
CCMK4_SYNY3
A:
[4-107]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
A
V
G
S
I
E
T
I
G
F
P
G
I
L
A
A
A
D
A
M
V
K
A
G
RI
T
I
V
G
Y
I
R
A
G
S
A
R
F
T
L
N
I
R
G
D
V
Q
E
V
K
T
A
M
A
A
G
I
D
A
I
N
R
T
E
G
A
D
V
K
T
W
V
I
I
P
R
P
H
E
N
V
V
--
A
V
L
P
I
D
-
F
S
P
E
V
E
P
F
R
E
A
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
27.48
26%
56
- C6 -
1WCG
2
MYRO1_BREBR
A:
[160-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-
W
I
T
F
N
E
P
I
A
V
C
K
G
Y
S
I
K
A
Y
A
PNL
N
L
K
T
T
G
H
Y
L
A
G
H
T
Q
L
I
A
H
G
K
A
---
Y
R
L
Y
E
E
M
F
K
P
T
Q
N
G
K
I
S
I
S
I
S
G
V
F
F
M
P
K
N
A
E
S
D
D
D
I
E
T
A
E
R
A
N
Q
F
E
R
G
W
F
G
H
P
V
Y
K
G
D
Y
-
P
P
I
M
K
K
W
V
D
Q
K
S
K
E
E
-
G
L
P
W
S
--
K
L
P
K
F
T
K
D
E
I
K
L
L
K
G
T
A
D
12
HHSearch
27.25
20%
-137
- C6 -
3RLF
1
MALF_ECOLI
F:
[13-83]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
K
W
S
V
-
L
G
L
L
G
L
L
V
G
Y
L
V
V
L
M
Y
A
Q
G
E
Y
L
F
A
I
T
T
L
I
L
S
S
A
G
L
Y
I
F
A
N
-
R
K
A
Y
A
W
R
Y
V
Y
P
G
M
A
G
M
G
L
F
V
L
F
P
L
V
C
T
I
A
I
A
F
T
N
Y
S
S
T
N
Q
L
T
F
E
R
A
-
Q
E
V
L
L
D
R
S
W
Q
----
A
G
----
K
T
Y
N
------
F
G
----------
L
Y
P
A
G
D
E
W
Q
L
A
L
S
D
G
E
T
G
K
--
N
Y
L
S
D
A
F
K
F
G
G
E
Q
K
L
Q
L
K
E
T
T
A
Q
P
E
G
E
R
A
N
L
R
V
I
T
Q
N
R
Q
A
L
S
D
I
T
A
I
L
P
D
G
N
K
V
M
M
S
S
L
R
Q
F
S
G
T
Q
P
L
Y
T
---
L
D
G
D
G
T
L
T
N
N
Q
S
G
V
K
Y
R
P
N
N
Q
I
G
F
Y
Q
S
I
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
T
G
W
K
N
F
T
R
V
F
T
D
E
G
I
--
Q
K
P
F
L
A
-
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
L
V
Q
W
E
A
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
-
L
G
Y
P
Y
M
M
I
L
C
M
-
G
L
L
K
A
I
P
D
D
--
L
Y
E
A
S
A
M
D
G
---
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
P
D
R
L
G
T
T
T
P
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
-
A
T
L
I
F
L
L
V
G
A
L
A
I
----------------------------
28
Fugue
24.85
8%
148
- C6 -
1JTH
-
SNP25_RAT
A:
[11-72]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
M
Q
R
R
A
D
Q
L
A
D
E
S
L
E
S
T
R
R
M
L
--
Q
L
V
E
E
S
-
K
D
A
G
I
R
T
L
V
M
L
D
E
Q
G
E
Q
L
E
R
I
E
E
G
M
D
Q
I
N
K
D
M
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
24.80
16%
234
- C6 -
2KHK
-
ATPF_ECOLI
A:
[1-53]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
A
I
E
K
R
Q
K
E
I
A
D
G
L
A
S
A
E
R
A
H
K
D
L
D
L
A
K
A
S
A
T
D
Q
L
K
K
A
K
A
E
A
Q
--
V
I
I
E
Q
A
-
N
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
23.89
17%
222
- C3 -
1I26
-
PTU1_PEITU
A:
[1-34]
--------------------------------------------
A
E
K
D
C
I
A
P
G
A
---
P
C
F
G
-
T
D
K
P
C
C
N
P
R
A
W
C
S
S
Y
A
N
K
C
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
23.86
20%
388
- C6 -
2RMY
-
BIN1_HUMAN
A:
[1-34]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
E
M
G
S
K
G
V
T
A
G
K
I
A
S
N
V
Q
K
K
L
T
R
A
Q
E
K
--
V
L
Q
K
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------