@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S352B_HUMAN: (2015-12-10 )
MSSSVKTPALEELVPGSEEKPKGRSPLSWGSLFGHRSEKIVFAKSDGGTDENVLTVTITETTVIESDLGVWSSRALLYLTLWFFFSFCTLFLNKYILSLLGGEPSMLGAVQMLSTTVIGCVKTLVPCCLYQHKARLSYPPNFLMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGLLVNLSLIPVMGGLALCTATEISFNVLGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVAMLVPARVFFTDVPVIGRSGKSFSYNQDVVLLLLTDGVLFHLQSVTAYALMGKISPVTFSVASTVKHALSIWLSVIVFGNKITSLSAVGTALVTVGVLLYNKARQHQQEALQSLAAATGRAPDDTVEPLLPQDPRQHP
Atome Classification :
(15 SA)
-------------.........10...--.....20.----------.......30........40........50..---------......60........70.......---.80........90........100.......110.......120.......130.......140.........150.......160..---.....170-----..-......--180.......190.---------......200.......210....-...220-----------.......230--........240.......250.......260.......270.......280.......290--...---------.....300.......310---------------........320.....-..330.......340---.........350.......360.......370....--------...380.----....--..390.......400--...--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MSSSVKTPALEELV--PGSEEKPK----------GRSPLSWGSLFGHRSEKIVFAKSDGGTDENV---------LTVTITETTVIESDLGVWSSRALLY---LTLWFFFSFCTLFLNKYILSLLGGEPSMLGAVQMLSTTVIGCVKTLVPCCLYQHKARLSYPP--NFLMTMLFVGLMRFATVVLGLVSL---KNVAVSF------AE-TVKSSA--PIFTVIMSRMILGE---------YTGLLVNLSLIPVMGGLALCTAT-EISFNV-----------LGFSAALST---NIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVAMLVPARVFFTDVPVIGRSGKSFS---YNQ---------DVVLLLLTDGVLFHLQS----------------VTAYALMGKISPVTFS-VASTVKHALSIWL-----SVIVFGNKITSLSAVGTALVTVGVLLYNKARQHQQE--------ALQSLAA----ATGR--APDDTVEPLLPQDPR--QHP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
78.34
22%
-93
- C1 -
3FHC
-
NU214_HUMAN
A:
[9-405]
---------I
P
E
R
E
M
K
D
F
Q
F
R
A
L
K
K
V
R
IF
D
S
P
E
E
L
P
K
----------
E
R
S
S
L
L
A
V
S
----
N
K
Y
G
L
V
F
A
G
G
A
S
G
--------------
L
Q
I
F
P
T
K
N
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N
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I
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D
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Q
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L
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M
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H
L
A
L
S
--------
C
D
N
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M
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Y
--
G
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--
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M
K
W
N
P
T
V
P
---
S
M
V
A
V
C
L
------
A
D
----
G
S
I
--
A
V
L
Q
V
-------------------
T
E
T
V
K
V
C
A
T
L
P
S
T
V
A
-----
V
T
-
S
V
C
W
S
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-----------
K
G
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Q
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A
V
G
K
QNG
T
V
V
Q
Y
L
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T
L
Q
E
K
K
V
I
---------
P
C
P
P
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D
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I
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V
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A
I
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---
Y
A
A
ADGTLE
T
S
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D
V
V
M
A
L
L
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K
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E
E
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H
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E
I
----------------
F
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F
-----
M
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G
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-
C
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H
---
Y
Y
L
-----
S
Y
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A
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A
A
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E
---
V
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I
N
W
E
S
--------
W
L
L
E
D
S
S
RA
E
L
P
V
T
D
--
K
S
D
D
S
L
P
M
G
V
V
V
D
Y
T
--
N
A
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V
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M
L
L
S
TDG
V
L
C
P
F
Y
M
I
N--------------------------------------------------------------------------------------------------------------------------------------------------------------
10
Fugue
57.89
13%
-85
* C3 *
1E6V
5
MCRA_METKA
A:
[8-552]
----------LF
M
K
A
L
K
E
K
F
E
------------
E
S
P
E
EK
Y
T
K
F
YIFG
G
W
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E
R
K
K
E
F
K
E
W
A
D
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E
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P
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I
GVPLGQRK
L
M
S
Y
Q
V
S
G
T
D
V
F
V
E
G
D
D
L
T
F
V
N
N
A
A
M
---
Q
Q
M
W
D
D
I
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I
V
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A
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I
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P
G
LT
W
D
C
Y
A
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I
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A
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D
I
E
K
L
F
P
E
E
Q
------
A
E
-
Q
L
I
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A
I
GN
R
T
Y
Q
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C
R
M
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H
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CD
G
A
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M
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A
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A
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A
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HAEVINM
G
E
M
L
P
A
R
R
A
R
G
E
---
N
E
P
G
G
V
P
F
G
V
L
A
D
C
V
Q
T
M
R
K
-
Y
P
D
D
P
A
K
V
A
L
E
V
I
A
A
G
A
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D
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G
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Y
M
S
G
G
V
G
F
T
Q
Y
A
T
A
V
Y
P
D
---------
N
I
L
D
D
Y
V
Y
Y
G
L
E
Y
V
E
D
K
YGIAEAEPS
M
D
V
V
K
D
V
A
T
E
V
T
L
Y
G
L
E
Q
Y
E
R
Y
P
-
A
A
M
E
T
H
F
G
G
S
Q
R
A
-----
A
V
C
A
A
A
A
G
C
S
T
A
F
A
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G
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A
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A
G
L
N
G
W
Y
L
S
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I
L
H
K
E
G
Q
GRLGFYGY
A
L
Q
D
Q
C
G
----
A
A
N
S
--
L
S
V
R
S
D
E
G
L
-
P
L
E
L
R
GP
N
Y
P
NYAMNVGH
L
G
E
Y
A
G
I
V
Q
A
A
H
A
A
R
GDAFCVH
P
V
I
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V
A
F
A
DENLVFDFTE
P
R
K
E
F
A
K
G
A
L
RE
F
E
P
A
GERDLIVPA-------------------------------------------------------------------------------------------------------
18
Fugue
50.69
9%
-72
- C2 -
1W63
-
AP1G1_MOUSE
A:
[1-589]
MPAPIR
L
R
E
L
I
R
T
I
R
T
A
R
T
Q
A
E
E
R
E
M
I
--
Q
K
E
C
A
A
I
R
----------
S
S
F
R
E
E
D
N
T
Y
R
C
R
N
V
A
K
L
L
Y
M
H
M
L
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---
Y
P
A
---------
H
F
G
Q
L
E
C
L
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L
I
A
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Q
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F
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D
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I
G
Y
L
G
---
A
M
L
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M
T
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C
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D
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N
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L
A
L
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T
L
G
C
M
G
S
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M
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A
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E
V
E
K
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N
--
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A
A
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C
A
V
H
V
I
R
K
V
P
E
L
M
E
M
---
F
L
P
A
T
K
N
LLNEKN
H
G
-
V
L
H
T
S
V
--
V
L
L
T
E
M
C
E
R
S
P
D
M
L
---------
A
H
F
R
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P
Q
L
V
R
I
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K
N
L
I
M
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G
Y
S
-
P
E
H
D
V
S
-----------
G
I
S
D
P
F
L
Q
V
---
R
I
L
R
L
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R
I
L
G
R
N
D
D
D
S
S
E
A
M
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D
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A
T
N
T
E
T
S
K
N
V
G
N
A
I
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Y
E
T
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L
T
I
M
D
I
K
S
E
S
G
L
R
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---
L
A
I
---------
N
I
L
G
R
F
L
L
N
N
-----
D
K
----------------
N
I
R
Y
V
A
L
T
S
L
L
K
T
V
Q
T
-
D
H
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A
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-----
D
C
L
K
D
L
D
V
S
I
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R
R
A
M
E
L
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F
A
L
V
N
---
G
N
N
I
R
G
M
M
K
E
--------
L
L
Y
F
L
D
S
----
C
E
P
E
--
F
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A
D
C
A
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--
Y
A
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L
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AGSYVRDD
A
V
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S
VEM
H
A
Y
T
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R
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A
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D
YSQQ
P
L
V
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A
A
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C
I
G
EYGDLLVSGQCEE
E
E
P
I
Q
VT
E
D
E
V
L
D
I
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E
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V
L
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SNMST
S
V
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R
G
Y
A
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A
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M
K
L
STRFTCTVN
R
I
K
K
V
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S
I
Y
GSSID
V
E
L
Q
Q
R
A
V
E
Y
N
A
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F
K
KY
D
H
M
R
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A
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LE
R
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14
Fugue
38.29
13%
-20
- C3 -
2CTO
-
MAEL_HUMAN
A:
[1-93]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
S
S
G
M
P
-
N
R
K
A
S
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N
A
Y
Y
F
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Y
C
S
S
D
W
A
L
L
R
E
E
E
K
E
K
Y
A
E
--------
M
A
R
E
W
R
A
----
A
Q
G
K
DP
G
P
S
E
K
Q
K
P
V
F
T
S
G
P
S
--
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
37.53
19%
-148
- C- -
3B5D
1
EMRE_ECOLI
A:
[33-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
G
T
I
I
C
Y
C
A
S
F
----------------
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
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G
V
G
I
V
L
I
S
L
L
-----
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
I
G
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
32.27
12%
-143
- C- -
3B5D
1
EMRE_ECOLI
A:
[30-105]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
P
S
V
G
T
I
I
C
Y
C
A
S
F
W
L
L
A
Q
T
L
---
A
Y
I
P
T
G
I
------
A
Y
A
I
W
S
G
V
G
--
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
---------
R
L
D
L
P
A
I
I
G
M
M
L
I
C
A
G
V
L
I
I
N
L
L
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
Fugue
24.30
24%
208
- C3 -
1G39
-
HNF1A_MOUSE
C:
[1-29]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
S
K
L
S
Q
L
Q
T
E
--------
L
L
A
A
L
L
E
-----
S
G
L
--
S
K
E
A
L
I
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
Fugue
23.19
26%
374
- C3 -
1T6O
1
B:
[1-19]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
S
R
R
S
A
D
--------
A
L
L
R
L
Q
A
----
M
A
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
Fugue
23.08
25%
210
- C3 -
1Y03
-
ANP3_MYOSC
A:
[1-35]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
N
A
P
A
R
A
A
A
K
T
--------
A
A
D
A
L
A
A
----
A
K
K
T
--
A
A
D
A
A
A
A
A
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
21.69
15%
152
- C3 -
2JXG
-
?
A:
[1-45]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
T
T
T
L
G
V
K
L
D
D
P
T
R
E
--------
R
L
K
A
A
A
Q
----
S
I
D
R
--
T
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H
W
L
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K
Q
A
I
F
N
Y
L
E
--
K
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
19.08
22%
241
- C3 -
3M91
-
PUP_MYCTU
B:
[21-51]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
A
A
G
Q
E
R
R
E
--------
K
L
T
E
E
T
D
----
D
L
L
D
--
E
I
D
D
V
L
E
E
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
Fugue
17.42
27%
244
- C3 -
2JX6
-
DDSK_PHYDS
A:
[1-33]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
W
S
K
I
K
A
A
G
K
E
--------
A
A
K
A
A
A
K
----
A
A
G
K
--
A
A
L
N
A
V
S
E
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
11.54
20%
252
- C3 -
2JO1
-
PLM_HUMAN
A:
[23-42]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
G
I
L
F
I
L
G
I
L
I
V
L
S
R
R
C
R
C
K
F
--------
N
Q
Q
Q
R
T
G
----
E
P
D
E
--
E
E
G
T
F
R
S
S
I
R
R
L
S
T
R
--
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
9.84
16%
232
- C3 -
3GIA
3
Y609_METJA
A:
[401-425]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
--------
R
T
F
S
N
N
M
----
Y
V
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
1.43
14%
366
- C3 -
2ZXE
-
?
G:
[26-42]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
A
V
L
C
V
I
G
I
I
I
L
L
A
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------