@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35A1_HUMAN: (2015-12-10 )
MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20.....-...30........40.----.......50........60........70........80------....----.....90........100.......110......-.120.......130.....---------..140.......150...-....160--......----.170.......180------------.....---...190-.......---..200.....-..-210-.-----------......220.......230........240....--.------.-.250.......260.......270-.-.-.....280......--.290.--......300.....--..310.......320.....-..330.....-----------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAPRDN
V
T
L
L
F
K
L
Y
C
L
A
V
M
T
L
M
A
A
V
-
Y
T
I
A
L
R
Y
TRTSDK
E
L
Y
----F
S
T
T
A
V
C
I
T
E
V
I
K
L
L
L
SV
G
I
L
A
KETGS
L
G
R
F
K
A
S
L
R
E
N
-------VLG
S
----
P
K
E
L
L
K
LS
V
P
S
L
V
Y
A
V
QN
N
M
A
F
L
A
LSNLD
A
A
V
Y
Q
-
V
T
Y
Q
LKI
P
C
T
A
L
C
T
V
L
M
L
N
---------
R
T
L
S
K
L
Q
W
V
S
V
F
M
L
CAG
V
-
T
L
V
Q
WKP--AQ
A
T
K
V
----
V
V
EQNPLL
G
F
G
A
I
-------------
A
I
A
V
L
---
C
S
G
F
---
A
G
V
Y
F
E
K
---
V
L
KSSD
T
S
L
W
-
V
R
-
N
I
Q
-
M
-----------
Y
L
S
G
I
I
V
T
L
A
G
V
YLSDG-AEIKEK
G
F
F
Y
G
Y
T
Y
Y
V
--
W
------
F
-
V
I
F
L
A
S
VG
G
L
Y
T
S
V
V
V
K
Y
T
D
N
I
M
K
-
G
-
F
-
S
A
A
A
A
I
V
L
S
T
I
A
S
V
--
M
L
F
G
L
--
Q
I
T
L
T
F
A
L
G
T
L
L
V
C
--
V
S
I
Y
L
YGLPRQDTTSIQQGE-TASKERVIGV-----------------------------------------------------------------------------------------------------------
26
Fugue
80.87
15%
-100
- C2 -
4CGK
2
?
A:
[42-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SN
L
T
A
Q
Q
Q
E
A
Q
K
Q
V
D
Q
I
Q
E
Q
V
S
A
I
Q
A
E
Q
-
S
N
L
Q
A
E
N
D
R
L
Q
A
E
S
K
K
----
L
E
G
E
I
T
E
L
S
K
N
I
V
S
R
N
Q
S
L
E
K
Q
A
R
S
A
Q
T
N
G
A
V
T
S
Y
I
N
T
-------
I
V
N
S
KSI-
T
E
A
I
S
R
V
A
A
M
S
E
I
V
S
A
N
N
K
M
L
E
Q
Q
K
A
D
K
K
A
I
S
E
K
-
Q
V
A
N
N
D
A
I
N
T
V
I
A
N
Q
Q
K
L
A
---------
D
D
A
Q
A
L
T
T
K
Q
A
E
L
K
A
A
E
L
-
S
L
A
A
E
K
A
TA
E
G
E
K
A
S
----
L
L
E
Q
K
A
A
A
E
A
E
A
R
-------------
A
A
A
V
A
---
E
A
A
Y
---
K
E
K
R
A
S
Q
Q
Q
S
V
L
A
S
A
N
T
N
L
T
-
A
Q
-
V
Q
A
-
V
-----------
S
E
S
A
A
A
P
V
R
A
K
V
R
P
T
Y
S
-
T
N
A
S
S
----
Y
P
I
G
E
C
T
--
W
------
G
-
V
K
T
L
A
P
W
A
G
D
Y
W
G
N
G
A
Q
W
A
T
S
A
A
A
A
G
-
F
-
R
T
G
S
T
P
Q
V
G
A
I
A
C
W
N
D
G
G
Y
G
H
--
V
A
V
V
T
A
V
E
S
T
T
R
I
Q
--
V
S
E
S
N
Y
A
G
N
R
T
I
G
N
H
R
G
W
F
N
P
T
T
T
S
E
G
F
V
T
Y
I
Y
AD-------------------------------------------------------------------------------------------------------
19
Fugue
73.98
20%
-120
* C2 *
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKIK
G
D
I
T
V
E
N
V
H
F
T
Y
PSRPDVPILRG
M
N
L
R
V
N
AGQT
V
A
L
V
G
S
SGCG
K
S
T
I
I
S
L
L
L
RYYDVL
K
G
K
I
T
I
DGVDVRDIN
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
NCT
I
E
E
N
I
S
L
G
KEGIT
R
E
E
M
V
A
A
C
K
M
A
NA
E
K
F
I
K
T
L
PNGYNTLVGDR
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
RNPK
I
L
L
L
D
EATSALDAES
E
G
I
V
Q
Q
A
L
D
K
A
A
KG
R
T
T
I
I
I
A
HRLSTIRNAD
L
I
I
S
C
K
NGQVV
E
V
G
D
H
R
A
L
M
A
Q
QG
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
SA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
-------
H
K
E
A
----
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
-------
V
L
Y
L
L
N
T
C
A
Y
R
-
M
G
L
A
L
------------
I
I
---------
T
D
P
P
T
M
Q
P
M
R
V
L
R
V
M
Y
A
I
-
T
I
S
T
S
T
L
--
G
F
A
T
S
Y
----
F
P
E
Y
A
K
A
T
F
A
G
G
I
-------------
I
F
G
M
L
---
R
K
-----------------
I
S
K
I
D
S
L
S
-
L
A
-
G
E
K
-
K
-----------
K
L
Y
G
K
-
V
I
F
K
N
V
R
F
A
Y
--
P
E
R
P
E
I
E
I
L
K
G
L
S
F
S
V
E
P
G
------
Q
-
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
-
T
-
L
-
G
G
E
I
F
I
D
G
S
E
I
K
T
L
--
N
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
D
C
S
I
A
E
N
I
I
Y
G
L
D
P
S
S
V
T
M
A
Q
V
E
E
-
A
A
R
L
A
N
I
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
20
Fugue
62.17
12%
-50
* C4 *
2LGZ
-
A:
[1-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
S
S
H
H
H
H
H
H
S
S
G
L
----------------------------------------------
V
P
R
G
S
H
S
T
W
V
T
R
T
A
Y
S
S
P
S
V
V
L
P
S
Q
-------
T
P
D
G
----
K
L
A
L
I
D
D
F
R
E
A
Y
Y
W
L
R
M
N
S
------
D
E
D
S
K
V
A
A
W
-
W
D
Y
G
Y
Q
I
G
G
M
A
D
R
T
T
L
V
D
N
---------
N
T
W
N
N
T
H
I
A
I
V
G
K
A
N
A
S
P
----
E
E
K
S
--
Y
E
I
L
K
E
----
H
D
V
D
Y
V
L
V
I
F
G
G
L
-------------
I
---------
G
F
---
G
G
D
D
I
N
K
---
F
L
W
N
I
R
I
S
E
G
-
I
W
-
P
E
E
-
I
-----------
K
E
R
D
F
Y
T
A
E
G
E
Y
R
V
D
A
R
A
S
E
T
M
R
N
S
L
L
Y
K
M
S
Y
K
D
--
F
------
P
-
Q
L
F
N
G
G
Q
---------
A
T
D
R
V
R
Q
Q
-
M
-
I
-
T
P
L
D
V
P
P
L
D
Y
F
D
E
V
--
F
T
S
E
N
--
W
N
V
R
I
Y
Q
L
K
K
D
D
A
Q
--
G
R
T
L
R
D
V
G
E
L
T
R
S
S
T
K
T
R
R
S
-
I
K
R
P
E
L
G
L
R
V
-----------------------------------------------------------------------------------------------------------
28
Fugue
60.32
16%
-151
- C1 -
4PW1
1
?
A:
[16-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
L
Y
L
N
S
G
E
E
L
N
L
Y
P
W
N
L
Y
T
G
Q
E
Q
-
E
L
F
E
E
E
I
V
S
F
A
A
N
S
V
R
I
L
G
GGSWTDEEL
Y
P
L
I
K
F
R
Y
S
G
Q
D
L
R
F
L
K
D
M
A
L
T
E
K
D
G
--
R
R
Y
L
V
N
M
---
A
L
D
P
N
G
L
C
Y
F
S
Y
V
N
QDEREAT
A
D
E
M
D
Q
A
L
G
K
---
L
Q
E
D
---
W
E
K
F
L
S
D
---
P
L
P
K
T
D
N
A
F
Y
M
F
F
M
R
C
Q
M
L
S
D
Q
M
R
K
E
QYSD
Y
I
G
D
N
L
Y
T
I
W
E
L
V
L
K
S
E
-
F
----
T
S
L
S
Y
D
N
H
I
Y
A
M
-
Y
S
N
DGG
T
S
M
V
L
I
Y
S
P
I
E
E
R
F
V
G
F
S
L
K
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
50.84
32%
-37
- C6 -
4GAH
2
THEM4_HUMAN
A:
[139-196]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
N
-
I
N
Y
K
R
P
I
P
---
L
C
S
V
V
M
I
N
---------
S
Q
L
D
K
V
E
G
R
K
F
F
V
S
C
-
N
V
-
Q
S
V
D
E
K
T
LY
S
E
A
T
S
L
----
F
I
K
L
N
P
A
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.39
22%
-27
- C3 -
2G7U
-
?
A:
[45-173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
R
I
L
L
T
L
Q
K
L
G
Y
V
A
G
S
G
G
R
W
S
L
T
P
R
V
L
-------
S
I
G
Q
H
Y
S
E
S
H
A
L
I
E
A
A
M
P
R
L
L
E
V
A
E
K
T
Q
E
S
A
S
L
G
V
L
D
G
A
--
D
-
V
V
Y
A
A
R
V
P
V
R
R
I
M
S
I
--------------
N
V
S
V
G
T
R
V
P
A
Y
A
T
S
M
G
R
-
A
L
L
A
W
A
P
--
A
D
V
V
E
R
----
V
V
A
E
S
T
F
Q
K
L
G
P
E
-------------
T
I
G
T
A
---
A
E
L
E
---
R
E
L
A
K
V
R
---
E
Q
G
F
A
L
T
S
E
E
-
L
E
-
K
G
L
-
I
-----------
S
L
A
A
P
V
H
D
A
G
G
T
V
V
G
V
V
-
A
C
S
T
S
S
A
R
N
T
P
A
Q
F
R
E
--
Q
------
A
-
V
P
C
V
L
A
A
A
A
A
L
S
A
D
M
G
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
49.28
32%
-52
* C6 *
4GAH
2
THEM4_HUMAN
B:
[139-196]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
N
-
I
N
Y
K
R
P
I
P
---
L
C
S
V
V
M
I
N
---------
S
Q
L
D
K
V
E
G
R
K
F
F
V
S
C
-
N
V
-
Q
S
V
D
E
K
T
LY
S
E
A
T
S
L
----
F
I
K
L
N
P
A
K
S
L
T
L
E
-------------
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
49.20
19%
-73
- C4 -
2VKJ
-
?
A:
[1-106]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
M
N
L
A
V
K
L
T
---------
R
M
E
K
T
L
K
A
Y
E
L
Y
I
F
S
D
Y
E
-
N
F
E
N
Y
V
K
--
K
E
G
L
K
I
EGME
L
L
K
E
K
K
A
R
S
L
I
A
E
-------------
G
K
D
L
F
E
T
A
N
Y
G
E
---
A
L
V
F
F
E
K
---
A
L
N
L
S
D
N
E
E
I
-
K
K
-
I
A
S
-
F
-----------
Y
L
E
E
C
R
K
K
L
A
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.92
32%
-39
- C6 -
4AE8
-
THEM4_HUMAN
A:
[178-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
N
-
I
N
Y
K
R
P
I
P
---
L
C
S
V
V
M
I
N
---------
S
Q
L
D
K
V
E
G
R
K
F
F
V
S
C
-
N
V
-
Q
S
V
D
E
K
T
LY
S
E
A
T
S
L
----
F
I
K
L
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
43.18
27%
2
- C3 -
1TMQ
-
IAAT_ELECO
B:
[53-106]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
C
R
C
E
A
V
R
I
L
M
D
-
G
V
V
T
----
S
S
G
Q
H
E
G
R
L
L
Q
D
-------
L
P
G
C
----
P
R
Q
V
Q
R
A
F
A
P
K
L
V
T
E
V
E
C
N
L
A
T
I
H
G
G
P
F
C
L
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.21
23%
43
- C3 -
3WNV
-
?
A:
[254-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
A
L
E
S
G
K
V
A
S
V
G
L
D
V
Y
E
N
EPQVE
P
G
L
L
N
N
----
P
R
A
M
L
L
P
H
I
G
T
M
T
Y
E
T
Q
K
E
M
E
L
L
V
L
N
N
L
R
S
A
I
E
K
-
G
E
L
L
T
Q
V
P
E
Q
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
38.22
12%
-105
- C- -
3B5D
1
EMRE_ECOLI
A:
[31-105]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
P
S
V
G
T
I
I
C
Y
C
A
S
F
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
---------
Q
R
L
D
L
P
A
I
I
G
M
M
L
I
C
A
G
V
-
L
I
I
N
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
37.46
27%
21
- C3 -
1BIP
-
IAAT_ELECO
A:
[53-106]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
C
R
C
E
A
V
R
I
L
M
D
-
G
V
V
T
----
S
S
G
Q
H
E
G
R
L
L
Q
D
-------
L
P
G
C
----
P
R
Q
V
Q
R
A
F
A
P
K
L
V
T
E
V
E
C
N
L
A
T
I
H
G
G
P
F
C
L
S
L
L
G
-
A
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
28.90
37%
39
- C5 -
4I1I
2
?
A:
[87-123]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
----
V
V
T
A
D
P
R
V
A
F
D
G
V
-------------
A
I
A
I
M
---
C
G
A
F
P
RK
A
G
M
E
R
K
D
---
L
L
E
M
N
A
R
I
F
K
-
E
Q
-
G
E
A
-
I
-----------
A
A
V
A
A
S
D
C
R
V
V
V
V
G
N
P
A
-
N
T
N
A
L
I
L
L
K
S
A
Q
G
K
L
N
--
P
------
R
-
H
V
T
A
M
T
R
L
D
H
N
R
A
L
S
L
L
A
R
K
A
G
V
P
-
V
-
S
-
Q
V
R
N
V
I
I
W
G
N
H
S
S
T
--
Q
V
P
D
T
--
D
S
A
V
I
G
T
T
P
A
R
E
A
I
--
K
D
F
V
Q
V
V
R
G
R
G
A
E
I
I
Q
L
R
G
L
-
S
S
A
M
S
A
A
K
A
A
-----------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
28.76
37%
27
* C5 *
4H7P
-
?
A:
[87-123]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
----
V
V
T
A
D
P
R
V
A
F
D
G
V
-------------
A
I
A
I
M
---
C
G
A
F
PRK
A
G
M
E
R
K
D
---
L
L
E
M
N
A
R
I
F
K
-
E
Q
-
G
E
A
-
I
-----------
A
A
V
A
A
S
D
C
R
V
V
V
V
G
N
P
A
-
N
T
N
A
L
I
L
L
K
S
A
Q
G
K
L
N
--
P
------
R
-
H
V
T
A
M
T
R
L
D
H
N
R
A
L
S
L
L
A
R
K
A
G
V
P
-
V
-
S
-
Q
V
R
N
V
I
I
W
G
N
H
S
S
T
--
Q
V
P
D
T
--
D
S
A
V
I
G
T
T
P
A
R
E
A
I
--
K
D
F
V
Q
V
V
R
G
R
G
A
E
I
I
Q
L
R
G
L
-
S
S
A
M
S
A
A
K
A
A
-----------------------------------------------------------------------------------------------------------
11
HHSearch
26.17
18%
-45
- C3 -
2I68
-
EMRE_ECOLI
A:
[36-104]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
I
C
Y
C
A
S
F
W
L
L
A
Q
T
L
A
-----
I
A
-
Y
-
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
--
G
F
F
G
--------
A
I
I
G
M
M
L
I
C
--
A
G
V
L
I
I
N
L
L
---------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
24.30
18%
-
- C3 -
3B5D
1
EMRE_ECOLI
A:
[35-105]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
T
I
I
C
Y
C
A
S
F
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
-
Y
A
I
-
W
S
G
V
G
I
V
L
I
S
L
L
S
W
--
G
F
F
G
Q
--
R
L
D
L
P
A
I
I
G
M
M
L
I
C
--
A
G
V
L
I
I
N
L
L
S
--------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
23.02
6%
499
- C3 -
2KNC
-
ITA2B_HUMAN
A:
[987-1003]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
W
K
V
G
F
F
K
R
N
R
P
P
L
E
E
-
D
--------------------------------------------------------------------------------------------------------------------
15
HHSearch
22.93
26%
289
* C3 *
2JP3
-
FXYD4_RAT
A:
[24-42]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
G
L
L
C
I
--
A
G
I
A
L
A
L
S
G
K
C
K
C
R
R
N
H
T
P
S
-
S
L
P
E
K
V
T
P
L
I
-----------------------------------------------------------------------------------------------------------
17
HHSearch
17.36
13%
280
- C3 -
2JO1
-
PLM_HUMAN
A:
[23-37]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
G
I
L
F
I
--
L
G
I
L
I
V
L
S
R
R
C
R
C
K
F
N
Q
Q
Q
R
-
T
G
E
P
D
E
E
E
G
T
-----------------------------------------------------------------------------------------------------------