@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35A2_HUMAN: (2015-12-10 )
MAAVGAGGSTAAPGPGAVSAGALEPGTASAAHRRLKYISLAVLVVQNASLILSIRYARTLPGDRFFATTAVVMAEVLKGLTCLLLLFAQKRGNVKHLVLFLHEAVLVQYVDTLKLAVPSLIYTLQNNLQYVAISNLPAATFQVTYQLKILTTALFSVLMLNRSLSRLQWASLLLLFTGVAIVQAQQAGGGGPRPLDQNPGAGLAAVVASCLSSGFAGVYFEKILKGSSGSVWLRNLQLGLFGTALGLVGLWWAEGTAVATRGFFFGYTPAVWGVVLNQAFGGLLVAVVVKYADNILKGFATSLSIVLSTVASIRLFGFHVDPLFALGAGLVIGAVYLYSLPRGAAKAIASASASASGPCVHQQPPGQPPPPQLSSHRGDLITEPFLPKLLTKVKGS
Atome Classification :
(20 SA)
.........10........20........30---........40........50--........-------60........70.......-.80.....-...90........100.......------.110.......120......--.130.......140-.......-150--........-160.......170--------.......-..180.......190..---.....-200.......210.......------220.......--230.......240......--.250....-...260.......270.-......280.......290......-.300....-...310.......320.......330.......340.......350........360....------...370.......380.........390.....-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAAVGAGGSTAAPGPGAVSAGALEPG
T
A
S
A
A
---
H
R
R
L
K
Y
I
S
L
A
V
L
V
VQN
A
S
L
I
--
L
S
I
R
Y
A
RT-------LPGDR
F
F
A
T
T
A
V
V
M
A
E
V
L
K
-
G
L
T
C
L
L
L
L
-
F
A
Q
KRG
N
V
K
H
L
V
L
F
-
L
H
E
A
V
L
V
Q
------
Y
V
D
T
L
K
L
A
V
P
S
L
I
Y
T
L
QNN
L
--
Q
Y
V
A
ISNLPA
A
T
F
Q
-
V
T
Y
Q
L
K
I
-
L
T
---
T
A
L
F
S
V
L
M
-
L
N
R
S
L
S
R
L
Q
W
A
----------
S
L
L
L
L
F
T
-
G
V
A
I
V
Q
A
QQAGGGGPRP---LDQNP-GA
G
L
A
A
V
V
A
S
C
L
SSG
F
A
G
V
Y
------
F
E
K
I
LKGSSG--
S
V
W
L
RNLQL
G
L
F
G
T
A
L
G
L
V
--
G
L
WWAEG
T
-
A
V
A
TR
G
F
FFGY
T
P
A
V
W
G
-
V
V
L
N
Q
A
F
G
G
L
L
V
A
V
V
V
K
Y
A
D
N
I
L
K
G
-
F
A
T
S
L
S
I
V
-
L
S
T
V
A
S
I
R
L
F
G
F
HV
D
P
L
F
A
L
G
A
G
L
V
I
G
A
V
Y
L
YSLP
R
G
A
A
K
A
I
A
S-ASASASGPCVHQQPPG------QPPPP
Q
L
SSHRGDL--ITE
P
F
L
P
K
L
L
T
-
K
VKGS-----------------------
19
Fugue
85.36
20%
-105
- C4 -
4OO3
-
?
A:
[3-441]
E
G
F
T
G
A
--------
P
G
E
V
K
L
I
T
L
D
P
G
H
F
H
A
A
L
V
Q
K
V
S
Y
P
Q
V
S
K
D
V
Y
V
Y
A
P
T
G
F
D
--
V
D
-
E
H
L
K
R
-------
I
Q
G
F
N
T
R
A
E
N
P
T
A
W
N
E
I
V
Y
-
T
G
D
D
Y
L
E
K
M
L
A
E
K
K
G
N
V
------
M
I
Q
A
G
N
N
G
K
------
K
T
E
Y
I
K
K
T
L
E
A
G
I
N
V
L
S
D
K
P
MA
I
N
S
Q
S
F
K
L
L
E
E
C
F
A
-
I
A
K
Q
K
N
I
M
L
Y
D
I
M
T
E
R
N
E
I
T
T
M
L
Q
R
E
L
S
T
I
P
A
V
YGEQLKGSPE
E
P
A
I
V
K
E
-
S
V
H
H
L
F
K
L
V
D
N
K
P
L
T
R
P
VWY
L
D
V
N
Q
Q
G
E
G
I
V
D
V
T
T
H
L
V
D
L
V
Q
W
E
A
F
PDQIID
Y
R
K
D
I
E
L
I
D
A
--
N
R
W
T
T
S
I
S
P
E
E
F
K
Q
V
T
G
-
T
--
D
A
Y
P
D
F
L
K
-
K
D
V
E
N
D
T
L
K
V
Y
C
N
G
D
I
V
-
Y
K
I
K
----
G
V
T
A
K
V
S
V
I
W
N
Y
T
F
P
K
G
-
G
G
D
T
H
F
S
V
M
K
G
S
K
A
D
L
V
I
R
Q
G
K
E
Q
N
Y
Q
P
---
E
L
F
V
E
A
V
K
G
V
D
L
A
A
Y
E
K
D
L
T
A
S
M
E
K
V
S
A
E
Y
P
G
V
A
L
N
K
V
G
DG
V
W
Q
V
E
I
P
A
K
Y
R
V
G
H
E
A
H
F
G
Q
V
T
E
H
F
L
D
Y
L
K
E
G
K
L
P
D
W
E
V
P
N
M
L
A
K
Y
Y
T
T
T
S
A
L
D
M
A
K
A
K
T
24
Fugue
64.94
12%
-113
- C5 -
1ZSW
1
?
A:
[11-338]
V
D
L
G
T
E
N
L
Y
F
Q
S
N
A
M
Y
E
I
K
----------------------
G
H
H
H
I
S
M
V
T
K
N
A
N
--
E
N
N
H
F
Y
K
N
-------
V
L
G
L
R
R
V
K
M
T
V
N
-----
Q
D
-
D
P
S
M
Y
H
L
F
-
Y
G
D
K
T
G
S
P
G
T
E
L
S
F
-
F
E
I
P
L
V
G
R
T
YRGTN
A
I
T
R
I
G
L
L
V
P
S
-
E
D
S
L
H
Y
W
K
--
E
R
F
E
K
F
D
V
K
H
S
E
M
T
-
T
Y
A
N
R
P
A
-
L
Q
---
F
E
D
A
E
G
L
-----------------------
R
L
V
L
L
V
S
-
N
G
E
K
V
E
H
W
E
T
W
E
K
S
E
V
P
---
A
K
H
Q
I
--
Q
G
M
G
S
V
E
L
T
V
R
R
L
D
K
M
A
S
T
------
L
T
E
I
F
----------------
G
Y
T
E
V
S
R
N
D
Q
--
E
A
I
F
Q
S
I
K
-
G
E
A
F
G
E
I
V
V
K
Y
L
D
---
G
-
P
T
E
K
P
G
R
G
S
I
H
H
L
A
I
R
V
K
N
D
A
E
L
A
Y
-
W
E
E
Q
V
K
Q
R
-
G
F
H
S
S
G
I
I
D
R
F
Y
F
K
S
L
Y
F
R
E
S
N
G
I
L
F
E
I
A
T
------
D
G
P
G
F
T
V
D
-
G
D
V
E
H
L
G
E
-------
K
------
L
D
L
P
P
F
L
E
D
Q
R
A
E
I
--
E
A
N
--
L
A
P
I
E
E
-
K
---------------------------
5
PsiBlast_PDB
54.09
30%
-82
- C6 -
3M6E
-
UT_DESVH
A:
[41-157]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
G
I
F
------
Y
N
S
T
T
L
G
V
C
A
V
L
G
T
A
A
S
T
L
T
A
Q
L
L
G
V
D
K
P
L
V
R
A
G
L
F
G
A
N
G
T
L
A
G
I
A
L
P
F
F
F
N
Y
E
P
A
M
L
G
Y
V
A
L
N
G
A
F
T
T
I
I
M
A
S
L
L
N
F
---
L
G
K
W
-
G
V
P
A
L
T
A
P
-
F
V
L
A
T
W
L
L
M
F
G
V
Y
K
L
S
L
F
H
P
G
A
L
I
A
P
A
L
P
S
V
A
D
M
G
T
V
T
G
R
T
F
M
E
-
G
L
F
K
G
V
G
E
V
M
F
Q
D
N
I
V
------
T
G
V
I
F
V
V
A
I
L
V
N
S
R
--
I
S
A
L
F
A
V
I
G
S
L
-
V
G
L
C
T
-----------------------
10
HHSearch
48.98
21%
-143
- C- -
3B5D
-
EMRE_ECOLI
A:
[51-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
Y
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
-
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
I
G
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
---------------------------------------------------------------------------------------
9
HHSearch
47.61
14%
-50
- C- -
3B5D
1
EMRE_ECOLI
A:
[30-105]
------------------------------------------------------------------------------------------------------------------------------------
L
W
P
S
V
G
T
I
I
C
Y
C
A
S
F
W
L
--
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
-
V
L
---
I
S
L
L
S
W
G
F
-
F
G
Q
R
L
D
L
P
A
I
I
----------
G
M
M
L
I
C
A
-
G
V
L
I
I
N
L
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
47.41
30%
-64
- C6 -
3BYD
-
BLO1_KLEOX
A:
[101-191]
-----------------
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
---
N
K
M
I
S
Y
L
G
G
P
E
K
V
T
A
F
A
Q
S
I
GD
V
T
F
R
L
D
R
T
EPALNSA
I
P
G
D
K
R
D
T
T
T
P
L
A
M
A
E
S
L
R
-
K
L
T
L
G
N
A
L
-
G
E
Q
Q
R
A
---
Q
L
V
T
W
-
L
K
G
N
T
T
G
G
------
Q
S
I
R
A
G
L
P
A
S
W
A
V
G
D
K
T
G
A
G
--
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
V
L
-
V
T
---
Y
F
T
Q
P
Q
Q
D
-
A
K
S
R
K
E
V
L
A
A
A
----------
A
K
I
V
T
E
G
-
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
43.08
18%
-80
- C6 -
4R80
-
?
A:
[2-77]
-------------------------
P
S
E
E
E
E
---
K
R
R
A
K
Q
V
A
K
E
K
I
L
E
Q
N
P
S
S
K
--
V
Q
V
R
R
V
Q
K
-------
Q
G
N
------
T
I
R
V
E
L
E
I
T
E
N
G
K
K
T
N
I
T
V
-
E
V
E
K
Q
G
N
T
F
T
V
K
R
I
-
T
E
T
V
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
34.79
35%
407
- C2 -
1PJM
-
RB_HUMAN
A:
[1-20]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
K
R
S
A
E
G
------
S
N
P
P
K
P
L
K
K
L
R
G
--------------------------------------------
4
PsiBlast_PDB
33.90
31%
-84
- C6 -
4WXB
2
GLYA_STRT1
A:
[51-106]
----------------------------------------
V
S
K
A
V
M
A
A
Q
--
G
T
L
--
L
T
N
K
Y
A
E
G
-------
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
-
A
I
E
R
A
K
K
L
-
F
G
A
K
F
A
N
V
Q
P
H
S
G
S
-
Q
A
N
A
A
V
Y
M
------
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
--
T
H
G
A
P
V
S
F
S
G
K
T
Y
N
-
F
V
S
Y
N
V
D
-
K
E
---
S
E
L
L
D
Y
D
A
-
I
L
A
Q
A
K
E
V
R
P
K
----------
L
I
V
A
G
A
S
-
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
---
V
G
A
Y
L
-
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
------
P
Y
A
H
V
T
T
T
T
T
--
H
K
T
L
R
G
P
R
G
G
L
I
L
T
D
D
E
D
I
--
A
K
K
L
N
S
A
V
-
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
-
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
-
A
D
V
F
N
Q
H
P
-
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
-
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
------
S
P
A
I
T
S
R
G
M
G
E
A
E
S
--
R
Q
I
A
E
W
M
V
E
A
L
-
E
N
H
D
K
-----------------------
2
PsiBlast_PDB
33.39
31%
-90
- C6 -
4WXG
1
GLYA_STRT1
A:
[51-106]
----------------------------------------
V
S
K
A
V
M
A
A
Q
--
G
T
L
--
L
T
N
K
Y
A
E
G
-------
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
-
A
I
E
R
A
K
K
L
-
F
G
A
K
F
A
N
V
Q
P
H
S
G
S
-
Q
A
N
A
A
V
Y
M
------
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
--
T
H
G
A
P
V
S
F
S
G
K
T
Y
N
-
F
V
S
Y
N
V
D
-
K
E
---
S
E
L
L
D
Y
D
A
-
I
L
A
Q
A
K
E
V
R
P
K
----------
L
I
V
A
G
A
S
-
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
---
V
G
A
Y
L
-
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
------
P
Y
A
H
V
T
T
T
T
T
--
H
K
T
L
R
G
P
R
G
G
L
I
L
T
D
D
E
D
I
--
A
K
K
L
N
S
A
V
-
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
-
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
-
A
D
V
F
N
Q
H
P
-
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
-
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
------
S
P
A
I
T
S
R
G
M
G
E
A
E
S
--
R
Q
I
A
E
W
M
V
E
A
L
-
E
N
H
D
K
-----------------------
3
PsiBlast_PDB
33.04
31%
-93
- C6 -
4WXF
1
GLYA_STRT1
A:
[51-106]
----------------------------------------
V
S
K
A
V
M
A
A
Q
--
G
T
L
--
L
T
N
K
Y
A
E
G
-------
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
-
A
I
E
R
A
K
K
L
-
F
G
A
K
F
A
N
V
Q
P
H
S
G
S
-
Q
A
N
A
A
V
Y
M
------
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
--
T
H
G
A
P
V
S
F
S
G
K
T
Y
N
-
F
V
S
Y
N
V
D
-
K
E
---
S
E
L
L
D
Y
D
A
-
I
L
A
Q
A
K
E
V
R
P
K
----------
L
I
V
A
G
A
S
-
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
---
V
G
A
Y
L
-
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
------
P
Y
A
H
V
T
T
T
T
T
--
H
K
T
L
R
G
P
R
G
G
L
I
L
T
D
D
E
D
I
--
A
K
K
L
N
S
A
V
-
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
-
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
-
A
D
V
F
N
Q
H
P
-
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
-
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
------
S
P
A
I
T
S
R
G
M
G
E
A
E
S
--
R
Q
I
A
E
W
M
V
E
A
L
-
E
N
H
D
K
-----------------------
16
Fugue
32.30
27%
122
- C6 -
2ZT9
3
PETN_NOSS1
H:
[1-29]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
I
L
T
L
G
W
V
----------
S
L
L
V
V
F
T
-
W
S
I
A
M
V
V
W
G
R
N
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
31.77
24%
112
- C6 -
2E74
3
PETN_MASLA
H:
[1-29]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
V
L
G
W
V
----------
A
L
L
V
V
F
T
-
W
S
I
A
M
V
V
W
G
R
N
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
31.35
34%
139
* C6 *
1VF5
1
PETN_MASLA
H:
[3-29]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
V
L
G
W
V
----------
A
L
L
V
V
F
T
W
S
I
A
M
V
V
W
G
R
N
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
30.89
24%
113
- C6 -
4H13
4
PETN_MASLA
H:
[1-29]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
V
L
G
W
V
----------
A
L
L
V
V
F
T
-
W
S
I
A
M
V
V
W
G
R
N
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
30.86
38%
110
- C3 -
2LJK
-
MIEN1_HUMAN
A:
[13-43]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
P
P
---
E
E
V
E
P
-
G
S
G
V
R
I
V
V
E
Y
C
E
P
C
G
F
E
A
T
Y
------
L
E
L
A
S
A
V
K
E
Q
--
Y
P
G
I
E
I
E
S
R
L
G
G
T
G
A
F
E
I
E
--
I
N
G
Q
L
V
F
S
-
K
L
E
N
G
G
F
P
Y
E
K
D
L
I
E
A
I
-
R
R
A
S
N
G
E
T
L
E
K
I
T
N
S
R
P
P
C
V
I
L
----------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
22.66
27%
92
- C6 -
3RKO
-
?
J:
[129-158]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
I
T
L
F
G
P
Y
V
L
A
V
E
L
A
S
M
L
L
L
A
G
L
V
V
A
F
H
V
G
R
E
E
R
A
G
E
V
L
-------------------------------------------------------------------------------
23
Fugue
22.59
50%
1380
- C1 -
1BBZ
-
?
F:
[4-11]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
Y
------
S
P
P
P
P
P
--------------------------------------------------
12
HHSearch
17.07
19%
223
- C6 -
2JP3
-
FXYD4_RAT
A:
[23-43]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
G
G
L
L
C
I
A
G
I
A
L
A
L
S
G
K
C
K
C
R
R
N
H
T
-
P
S
S
L
P
E
K
V
T
P
L
I
T
P
G
S
------
A
S
T
-----------------------------------------------------
11
HHSearch
16.66
10%
291
- C6 -
2ZXE
-
?
G:
[25-42]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
A
A
V
L
C
V
I
G
I
I
I
L
L
A
G
K
---------------------------------------------------------------------------------------