@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35B2_HUMAN: (2015-12-10 )
MDARWWAVVVLAAFPSLGAGGETPEAPPESWTQLWFFRFVVNAAGYASFMVPGYLLVQYFRRKNYLETGRGLCFPLVKACVFGNEPKASDEVPLAPRTEAAETTPMWQALKLLFCATGLQVSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNRVLALIVAGLSCVLCKQPRHGAPMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPEPRSSPATTLSGLILLAGYIAFDSFTSNWQDALFAYKMSSVQMMFGVNFFSCLFTVGSLLEQGALLEGTRFMGRHSEFAAHALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYARGRLKQRGKKAVPVESPVQKV
Atome Classification :
(13 SA)
------------------------------.........10........20....-....30.....-----...40........50--....------....60------........---70......-------..80......-..90........100.......110.......120-.......-----------..130---......------.140.......150--.....--..160.--......170.--......180.....---..190.......-------------200.......210-..--------....---------..220...-....230...-....---------240.......250-.......260.......270.......-280.......290.......300.......310.......320.......330.......340.......350......---.360-----.......-.------------370......--.380--------......--------------..-----------------390......--.400---------------........410.....----.--.420-------........430----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------MDA
R
W
W
A
V
V
V
LAAFPSLGAGGETPE-AP
P
E
S
W
T
Q
L
W
F
-----
F
R
F
V
VNAA
G
Y
A
S
F
M
V
--
P
G
Y
L
------
L
V
Q
Y
F
R
------RKN
Y
L
E
TG---R
G
L
C
F
P
L
V
-------
K
A
CVFGNEPK-ASDEVPLAPRTEAAET
T
P
M
W
Q
A
L
K
L
L
F
C
ATG
L
Q
---
V
S
Y
L
T
W
G
-----------
V
L
Q
E
R
---
V
M
T
RSY------GATATSPGERFT
D
S
--
Q
F
L
V
L
--
M
N
R
V
L
A
--
L
I
V
A
G
L
S
C
V
L--CKQPRHGAP
M
Y
R
Y
S
---
F
A
S
L
S
N
V
L
S
S
W
C
-------------
Q
Y
E
A
L
K
F
VS
F
P
T
--
Q
V
--------
L
A
K
A
---------
S
KV
I
P
V
M
L
-
M
G
K
L
V
S
RRS
Y
-
E
H
W
E
---------
Y
L
T
A
T
L
I
S
I
G
V
S
M
-
F
LLSSGPEPRSS
P
A
T
T
L
S
G
L
I
L
L
A
G
Y
I
-
A
F
D
S
FTS
N
W
Q
D
A
L
F
A
Y
K
MS
S
V
Q
M
M
F
G
V
N
F
F
S
C
L
F
T
V
G
S
L
L
EQGALLEG
T
R
FMGR
H
S
E
F
A
A
H
A
L
L
L
S
I
C
S
A
CG
Q
L
F
I
F
Y
T
---
I
G
Q
------
F
G
A
A
V
F
T
-
I
------------
I
M
T
L
R
Q
A
F
A
--
I
L
L
---------
S
C
L
LYG--------------
H
T
-----------------
V
T
V
VG
G
L
G
V
--
A
V
V
----------------
F
A
A
L
L
L
R
V
Y
A
R
G
R
L
K
Q----R--GKK--------AVPVESPVQKV----------------
10
Fugue
90.13
16%
-110
- C4 -
4NLE
-
?
A:
[18-485]
-------------------------TIPNV
L
A
N
R
Y
A
S
D
E
M
V
A
I
W
--------
S
P
E
-
A
K
I
I
A
E
R
R
L
W
L
-----
A
V
L
R
A
Q
A
E
--
L
G
V
A
V
--
P
D
G
V
------
V
E
D
Y
E
R
V
L
ENVD
L
E
S
I
A
A
R
E
---
R
V
R
H
D
V
K
A
-------
R
I
E
E
F
N
A
H
E
H
-
V
H
K
G
M
T
S
R
D
L
T
E
N
V
E
Q
L
Q
I
R
Q
S
L
E
L
V
F
S
H
G
V
A
V
---
V
A
R
L
A
E
R
-----------
A
V
V
Y
R
DL
V
M
A
G
R
S
H
NV----
A
A
Q
A
T
T
L
G
K
R
F
A
S
A
A
E
E
T
L
V
A
--
L
T
R
L
R
E
--
L
I
D
R
-
Y
P
L
R
G
--
V
K
G
P
M
G
T
A
Q
D
M
L
D
L
---
F
G
G
D
V
G
K
L
A
D
L
--------------
E
R
R
V
A
E
F
L
G
F
T
E
--
V
F
TSVGQVYP
R
S
L
D
---------
H
D
V
L
S
A
L
V
Q
F
G
A
G
P
S
S
M
A
H
-
T
I
R
L
---------
M
A
G
H
E
L
V
T
E
G
F
A
P
-
G
Q
V
G
S
S
A
M
P
H
K
M
N
T
R
S
C
E
R
V
N
G
L
Q
V
V
L
R
G
Y
A
S
M
A
A
E
L
A
G
A
Q
W
N
E
G
D
V
F
C
S
V
V
R
R
V
A
L
P
D
A
F
F
A
I
D
G
Q
T
E
--
T
F
L
T
V
L
D
E
F
G
A
Y
P
A
V
I
Q
R
E
L
D
R
Y
L
P
F
L
A
T
T
R
I
L
M
A
A
---
V
R
A
------
G
V
G
R
E
A
A
-
H
------------
E
V
I
K
E
H
A
V
A
--
V
A
L
---------
A
M
R
E
Q
G
--------------
R
E
-----------------
P
D
L
I
D
R
L
A
G
DP
R
L
P
----------------
L
D
K
V
A
L
E
A
A
L
E
D
K
Q
A
F
----
T
--
G
A
A
--------
G
D
Q
V
D
G
V
V
A
A
V
G
E
L
V
S
R
Y
PEAAKYTSG
9
Fugue
86.40
19%
-104
- C4 -
3ZK4
8
?
A:
[3-571]
H
A
Y
I
K
A
T
PNVLGFEGHY
T
E
W
V
T
L
Q
Y
S
N
NKP
S
I
D
D
W
I
G
V
F
S
P
A
N
F
S
A
S
T
C
P
G
E
N
K
M
T
N
P
P
F
L
C
S
A
P
I
K
-----
F
Q
Y
A
N
F
S
S
H
S
Y
K
D
T
G
--
K
G
S
L
------
K
L
Q
L
I
N
------
Q
R
S
---------
D
F
S
F
A
L
F
T
GGLT
N
P
K
L
I
A
V
S
N
K
V
S
F
V
N
P
N
A
P
V
Y
P
R
L
A
Q
G
K
T
---
W
D
E
I
T
V
T
W
T
S
G
Y
D
I
ND
A
E
P
F
V
E
W
G
PKE
G
N
------
L
V
K
T
P
---
A
G
T
L
T
F
D
RNTMC
G
A
P
A
R
T
V
G
W
R
D
P
G
Y
--
I
H
T
S
F
--
L
K
E
L
W
P
N
R
E
Y
T
Y
K
L
G
H
R
L
--
F
N
G
T
T
I
W
S
K
E
Y
H
F
K
A
S
P
Y
P
G
Q
S
S
V
Q
R
V
V
I
F
G
DM
G
K
A
E
ADGSN
E
Y
N
N
F
Q
P
G
S
L
N
T
T
K
Q
I
--------
I
Q
D
L
---------
E
D
I
D
I
V
F
H
-
I
G
D
L
C
Y
A
N
G
Y
I
S
Q
W
D
---------
Q
F
T
A
Q
I
E
P
I
A
S
T
V
P
Y
M
T
A
S
G
N
H
E
R
D
W
P
G
T
G
S
F
Y
G
N
L
D
S
G
-----
G
E
C
G
V
P
A
Q
T
M
F
F
V
P
A
E
N
R
E
K
F
W
Y
S
T
D
Y
G
M
F
R
F
C
I
-------
A
H
T
E
L
D
W
R
K
G
T
E
Q
Y
E
F
I
E
K
C
L
A
S
V
D
R
Q
K
Q
P
W
L
I
F
L
A
HRV
L
G
Y
------
S
S
A
G
F
Y
V
-
Q
E
GSFEEPMGR
E
D
L
Q
H
L
W
Q
K
Y
K
VD
I
A
M
Y
G
HVH
N
Y
E
R
T
C
P
I
Y
Q
--------------
N
V
CTNKEKHNYKGNLN
G
T
I
H
V
V
V
G
G
G
G
A
--
S
L
A
E
F
A
PINTTWSIFKDH
D
F
G
F
V
K
L
T
A
F
D
H
S
N
L
L
L
----
E
--
Y
R
K
SSDGQVY
D
S
F
T
I
S
R
D
Y
R
D
I
L
ACSVDS
C
P
T
T
T
LAS-
15
Fugue
76.61
21%
-105
- C2 -
4CZX
2
PAN2_NEUCR
A:
[1-324]
---------------------------P
H
M
M
D
S
R
D
W
T
Q
L
G
C
V
A
Y
P
S
----
P
I
H
P
D
-
Y
H
A
G
P
A
S
T
I
A
F
D
NQDE
L
L
W
I
G
T
Q
K
G
F
A
G
S
F
I
---
G
R
E
------
L
K
R
F
T
A
------
F
R
I
H
P
E
T
D
GPL
R
Q
F
L
F
V
D
K
-------
G
V
I
F
L
G
------
S
R
S
V
Y
M
A
A
R
S
G
----
V
P
I
W
S
I
----------------------------------
R
H
E
---
S
M
Q
D
L
R
------
A
M
S
F
T
S
K
G
----
T
S
--
E
I
L
V
A
G
W
Q
N
K
M
L
V
--
I
D
V
N
K
G
E
V
V
K
--
E
L
P
T
Q
D
-----
Q
Y
S
---
F
L
K
M
S
R
Y
I
C
A
A
T
-------------
N
K
G
T
V
N
I
L
D
P
I
T
--
F
T
--------
I
K
K
Q
---------
W
Q
A
------------------
H
G
A
---------
F
I
N
D
L
D
T
S
---
N
D
-
F
I
V
T
C
G
G
S
H
R
Q
T
H
N
T
P
------------------
A
I
L
D
P
Y
V
K
V
F
D
L
K
N
M
S
A
M
N
P
V
P
F
--------------------------
A
P
L
A
A
H
V
R
M
----------------------------
H
P
R
M
L
T
-
T
------------
A
I
V
V
N
Q
A
G
Q
--
I
H
V
---------
T
D
L
L
N
P
--------------
S
N
-----------------
S
Q
V
C
Y
T
Q
P
Q
--
G
V
V
----------------
L
H
F
D
V
S
R
T
-
G
E
G
K
A
L
A
----
D
--
N
K
H
--------
N
T
Y
V
W
G
S
P
N
K
I
QFTE------------
13
Fugue
71.54
11%
-97
- C3 -
4BES
2
ANKX_LEGPH
A:
[6-484]
--------------------------------
P
N
L
P
G
L
Y
F
L
Q
A
Y
P
------------
S
E
E
I
W
R
L
F
V
D
-----
G
R
F
W
S
K
E
N
G
W
R
G
Y
E
S
R
E
P
G
C
L
N
A
A
L
E
S
L
C
S
I
A
L
------
Q
V
E
K
S
G
E
E
---
F
E
L
S
V
D
L
I
-------
K
R
I
H
K
K
C
G
P
G
-
E
L
R
T
-
D
E
P
V
S
F
G
I
P
A
G
R
A
S
I
K
G
I
E
E
F
L
S
L
V
F
L
T
---
E
G
G
A
E
F
G
-----------
P
G
K
A
G
---
P
F
G
P
R
F
------
D
K
N
Y
F
K
N
L
N
P
E
Q
I
P
--
D
L
A
K
Q
--
I
Y
F
D
M
C
--
K
Y
G
H
S
N
T
N
H
F
--
Y
L
A
V
M
K
N
V
D
V
Y
L
E
K
---
I
T
Q
S
Y
N
K
E
I
K
T
A
-------------
E
T
L
D
E
K
L
K
I
I
V
K
--
H
I
--------
R
M
Y
E
V
L
HPFRDAN
G
R
T
F
V
N
N
L
-
L
N
I
P
L
M
Q
Q
G
L
-
P
P
A
T
F
YEPNVFDL
Y
S
A
E
E
L
V
V
V
V
K
E
A
-
I
F
N
T
V
E
I
I
E
Q
S
K
R
K
T
P
I
----
T
L
Y
G
Y
H
-
S
S
L
E
E
Q
T
K
F
R
D
M
L
D
S
P
S
Y
E
K
I
K
H
M
D
F
S
D
L
N
P
E
K
L
H
L
K
T
Q
K
C
L
S
S
L
N
E
Q
Y
P
L
H
R
G
A
I
Y
L
S
D
P
G
E
I
K
L
L
L
S
N
R
N
E
S
Q
I
N
Q
Q
---
I
E
Q
GAPPIY
V
G
K
T
P
A
H
-
L
------------
A
V
I
S
G
N
-
M
A
--
M
L
D
---------
E
L
I
A
K
K
ADLSLQDYDGKT
A
L
H
Y
-----------------
A
A
E
C
G
N
M
Q
I
--
M
G
K
----------------
I
L
K
V
V
L
S
Q
E
D
A
I
K
V
L
N
IKDN
H
--
G
K
T
--------
A
F
H
Y
A
A
E
F
G
T
P
ELISAL----------
16
Fugue
60.75
12%
-107
- C3 -
3RKX
-
?
A:
[3-323]
------------------------------
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
-
S
L
N
I
S
R
T
A
V
K
K
-----
V
I
D
Q
L
K
L
E
G
C
--------------------------------
K
I
D
S
V
---
N
H
K
G
H
L
L
Q
-------
Q
------
L
P
D
-
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
------------------------------------
F
S
E
V
Y
---
D
S
I
D
S
T
------
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
--
F
F
I
L
S
--
D
E
Q
T
S
K
--
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
---
A
L
G
I
R
D
A
I
Q
H
F
S
-------------
Q
D
E
--
V
K
V
K
W
P
N
--
D
I
--------
Y
I
D
N
---------
G
K
V
C
G
F
L
T
-
E
M
V
A
N
N
D
G
-----------------
I
E
A
I
I
C
G
I
G
I
N
L
-
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
-------------------------------
S
I
Q
L
H
D
K
-----------------------------
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
---
T
L
P
------
F
S
E
-----
I
------------
R
E
E
Y
N
A
A
S
N
--
I
W
---------------
N
--------------
R
T
-----------------
L
L
F
T
E
N
------
K
Q
----------------
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
----
R
D
E
A
G
E
--------
S
H
R
L
I
S
A
D
I
D
F
----------------
4
HHSearch
38.82
14%
-282
- C- -
3B5D
1
EMRE_ECOLI
A:
[33-105]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
G
T
I
I
C
Y
C
A
S
F
W
L
L
A
Q
T
---
L
A
Y
------
I
P
T
G
I
A
Y
A
I
------------
W
S
G
V
G
I
V
L
I
--
S
L
L
---------
S
W
G
F
F
G
--------------
Q
R
-----------------
L
D
L
P
A
I
I
G
M
--
M
L
I
----------------
C
A
G
V
L
I
I
N
L
L
S
--------------------------------------------------
1
PsiBlast_PDB
31.95
36%
-10
- C- -
4CAU
-
?
D:
[95-144]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
A
R
G
I
A
---
G
G
W
A
F
W
G
IDLWGQGTLVT
V
S
S
D
V
---
V
M
T
Q
S
P
------
G
T
L
S
L
S
P
G
E
R
A
T
L
S
--
C
R
A
S
Q
--
N
V
Y
S
Y
L
--
G
W
Y
Q
H
K
P
G
R
S
--
P
R
L
L
I
F
G
V
T
S
R
A
T
G
---
V
P
D
R
F
S
G
S
G
S
G
T
-------------
D
F
T
L
T
I
S
R
L
E
P
E
--
D
F
--------
A
V
Y
Y
---------
C
Q
Q
Y
A
G
S
A
-
Y
T
F
G
Q
G
T
K
V
E
-
I
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
Fugue
29.97
21%
320
* C4 *
4HTM
-
CRTC2_HUMAN
A:
[4-31]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
K
-
F
S
E
K
I
A
L
Q
K
Q
R
Q
A
E
E
T
A
A
F
E
E
V
M
M
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
29.40
35%
308
* C3 *
2LE7
-
KCNH2_HUMAN
A:
[532-551]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
R
V
A
R
K
L
D
R
Y
S
E
Y
G
A
A
V
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
24.86
13%
-28
- C- -
3B5D
1
EMRE_ECOLI
A:
[30-105]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
P
S
V
---
G
T
I
I
C
Y
C
A
S
F
W
L
-------------
L
A
Q
T
L
A
Y
I
P
T
G
I
--
A
Y
A
-------
I
W
S
G
---------
V
G
I
V
L
I
S
L
-
L
S
W
G
F
F
G
Q
R
L
-
D
L
P
A
---------
I
I
G
M
M
L
I
C
A
G
V
L
I
-
I
N
L
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
10.84
9%
237
* C5 *
2I9X
1
SP5G_STAES
A:
[19-40]
-----------------------------------------------------------------------------
R
M
K
A
L
V
S
I
T
L
--
D
E
A
F
------
V
I
H
D
L
R
------
V
I
E
G
N
S
G
L
---
F
V
A
M
P
S
K
R
-------
T
P
D
G
E
F
R
D
I
A
-
H
P
I
N
S
D
M
R
Q
E
I
Q
D
A
V
M
K
V
Y
D
E
T
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
10.70
17%
238
- C5 -
2IA9
1
SP5G_BACSU
A:
[18-40]
----------------------------------------------------------------------------
G
R
M
R
A
I
A
S
I
T
L
--
D
H
E
F
------
V
V
H
D
I
R
------
V
I
D
G
N
N
G
L
---
F
V
A
M
P
S
K
R
-------
T
P
D
G
E
F
R
D
I
T
-
H
P
I
N
S
S
T
R
G
K
I
Q
D
A
V
L
N
E
Y
H
R
L
G
D
T
E
A
L
E
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
7.52
15%
729
- C1 -
2L6W
-
PGFRB_HUMAN
A:
[26-38]
------------------------------------------------------------------------------------------
I
I
L
------
I
M
L
W
Q
K
------
K
P
R
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------