@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35F1_HUMAN: (2015-12-10 )
MIPPEQPQQQLQPPSPAPPNHVVTTIENLPAEGSGGGGSLSASSRAGVRQRIRKVLNREMLISVALGQVLSLLICGIGLTSKYLSEDFHANTPVFQSFLNYILLFLVYTTTLAVRQGEENLLAILRRRWWKYMILGLIDLEANYLVVKAYQYTTLTSIQLLDCFVIPVVILLSWFFLLIRYKAVHFIGIVVCILGMGCMVGADVLVGRHQGAGENKLVGDLLVLGGATLYGISNVWEEYIIRTLSRVEFLGMIGLFGAFFSGIQLAIMEHKELLKVPWDWQIGLLYVGFSACMFGLYSFMPVVIKKTSATSVNLSLLTADLYSLFCGLFLFHYKFSGLYLLSFFTILIGLVLYSSTSTYIAQDPRVYKQFRNPSGPVVDLPTTAQVEPSVTYTSLGQETEEEPHVRVA
Atome Classification :
(14 SA)
-------------------------------------------------------------.........10........20........30........40......-------..50.....----...60........70.......----------.80........90..----......100.......110-.......120.......130.......140.......150.....-------------..-160...--------....-----170.......180.-----------......190.....-..200..--------....---------.210.......220.....----------..230..---.....240.......250.......260.......270.......280.......290----.......------.300.......310.-......320.......330.......340.......350.......360.......370------.......380.......390.......400......--------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------MIPPEQ
P
Q
QQLQPPSPAPPNHV
V
T
T
I
E
NLPAEGSGGGGSLS
A
S
S
R
A
G
-------
V
R
Q
R
I
R
K
V
L
----
N
R
E
M
L
I
S
V
A
L
G
Q
V
L
S
L
L
I
C
GIG----------L
T
S
K
Y
L
S
E
DFHAN
T
P
----
V
F
Q
S
F
L
N
Y
I
L
L
F
L
V
Y
T
T
T
L
-
A
VRQG
E
E
N
L
L
A
I
L
R
R
R
W
W
K
Y
M
I
L
G
L
I
DLEA
N
Y
L
V
V
K
A
Y
Q
Y
T
T
L
T
S
-------------
I
Q
-
L
L
D
C
F
V
--------
I
P
V
V
-----
I
L
L
S
W
F
F
L
L
I
R
Y
K
A
-----------
V
H
F
I
G
I
V
V
C
I
LG
M
G
-
C
M
V
G
A
D
V
--------LVGR---------HQGAGENKL
V
G
D
L
L
V
LG
G
A
----------
T
L
Y
G
I
S
N
---
V
W
E
E
Y
I
I
R
T
L
S
R
V
E
F
L
G
M
I
G
L
F
G
A
F
F
S
G
I
Q
L
A
I
M
E
H
K
E
L
LKVPWDWQ
I
G
L
L
Y
V
G
F
S
A
-----
C
M
F
G
L
Y
S
------
F
M
P
V
V
I
KKTSA
T
S
V
N
-
L
S
L
L
T
A
D
L
Y
S
L
F
C
G
L
F
L
F
H
Y
KFS
G
L
Y
L
L
S
F
F
T
I
L
I
G
L
V
LYSSTSTYIAQD
P
R
V
Y
K
Q
FRN------PSG
P
V
VDLPTTAQVEPS
V
T
Y
TSLGQETEEEPHVRVA--------------------------
3
Fugue
85.09
16%
-108
- C3 -
3V9J
2
AL4A1_MOUSE
A:
[20-563]
HM
L
R
W
K
H
T
S
S
L
K
V
A
N
EPILAFSQGS
P
E
R
D
A
L
Q
K
A
L
K
D
L
KGQTEAIPCVVGD
E
E
V
W
T
SD
I
Q
Y
Q
L
S
P
F
N
H
A
H
K
V
A
K
F
C
Y
A
D
K
A
L
L
N
R
A
I
D
A
A
L
A
A
R
K
E
W
D
L
-
K
P
M
A
D
R
A
Q
-------
V
F
L
K
A
A
D
M
L
S
GPR
R
A
E
V
L
A
K
T
M
V
G
Q
G
K
T
V
I
Q
A
E
I
D
AA
A
E
L
I
D
F
F
R
F
N
A
K
F
A
V
E
L
E
G
E
Q
P
I
S
V
P
P
S
T
N
H
T
V
Y
R
G
L
E
G
F
V
A
A
I
S
-------
P
F
N
F
T
A
I
G
G
N
L
A
G
A
P
A
L
M
G
------
N
V
V
L
W
K
P
S
D
T
A
M
L
A
S
-------------
Y
A
-
V
Y
R
I
L
R
E
A
GLPPNI
I
Q
F
V
PAD
G
P
T
F
G
D
T
V
T
S
S
E
H
L
C
G
-----------
I
N
F
T
G
S
V
P
T
F
K
H
L
W
-
R
Q
V
A
Q
N
L
DRFR
T
F
P
R
L
A
G
E
C
G
G
K
N
F
H
F
V
H
S
S
A
D
V
D
S
V
V
S
G
T
L
R
S
A
F
E
YGGQKCSACS
R
L
Y
V
P
K
S
---
L
W
P
Q
I
K
G
R
L
L
E
E
H
S
R
I
K
-
V
G
D
P
A
E
D
F
G
T
F
F
S
A
V
I
D
A
K
A
F
A
R
I
K
K
W
L
E
H
A
R
S
S
P
S
L
S
I
-----
L
A
G
G
Q
C
N
ESVGYY
V
E
P
C
I
I
E
S
K
D
P
---
Q
-
E
P
I
M
K
E
E
I
F
----
G
P
V
L
T
V
Y
V
Y
P
D
D
K
Y
R
E
T
L
K
L
V
D
S
T
T
S
Y
G
L
T
G
A
V
F
A
Q
D
K
A
I
V
Q
E
A
T
R
M
L
R
NAA
G
N
F
Y
I
N
D
K
S
T
G
S
V
V
G
Q
Q
P
F
G
G
A
R
A
S
G
T
N
D
K
P
G
G
P
H
Y
ILRW
T
S
P
Q
V
I
K
E
T
HKPLGDWRYSYMQ
6
Fugue
79.82
13%
-99
- C3 -
3MK7
4
CCON1_PSEST
A:
[5-470]
--------------------------TSTAYSY
K
V
V
R
Q
F
A
I
M
T
V
V
W
G
I
V
G
M
G
L
G
V
F
I
A
A
Q
L
A
W
P
F
L
N
F
D
L
P
W
T
S
F
G
R
L
R
P
L
H
T
N
A
V
I
F
------
A
F
G
G
C
A
L
F
A
T
S
Y
Y
S
-------
V
Q
R
T
C
Q
T
T
L
----
F
A
P
K
L
A
A
F
T
F
W
G
W
Q
L
V
I
L
L
A
A
I
----------
S
L
P
L
G
F
T
S
S
K
E
Y
A
E
L
----
E
W
P
I
D
I
L
I
T
I
V
W
V
A
Y
A
V
V
F
F
G
T
L
A
K
R
K
V
K
H
I
Y
V
G
N
W
F
F
G
A
F
I
L
T
V
A
I
L
H
V
V
N
N
L
E
I
P
V
T
A
M
K
S
Y
S
LYAG
A
T
D
A
M
V
Q
W
W
Y
G
-
H
N
A
V
G
F
--------
F
L
T
A
-----
G
F
L
G
I
M
Y
Y
F
V
P
K
Q
A
ERPVYS
Y
R
L
S
I
V
H
F
W
A
L
I
T
V
Y
I
W
A
G
P
H
H
L
H
Y
T
A
--------
L
P
D
W
---------
A
Q
S
L
G
M
V
M
S
L
I
L
L
A
P
S
W
G
G
----------
M
I
N
G
M
M
T
L
SG
A
W
H
K
L
R
S
D
P
I
L
R
F
L
V
V
S
L
A
F
Y
G
M
S
T
F
E
G
P
M
M
A
I
K
T
V
N
A
L
S
H
Y
T
-
D
W
T
I
G
H
V
H
A
G
A
L
G
W
V
A
M
V
S
I
G
A
L
Y
H
------
L
V
P
K
V
F
G
R
E
Q
M
H
S
I
G
-
L
I
N
T
H
F
W
L
A
T
I
G
T
V
L
Y
I
A
S
M
W
V
N
G
I
A
Q
G
L
M
W
R
A
I
N
D
D
G
T
L
T
Y
S
F
V
E
S
L
E
A
S
H
P
G
F
V
V
R
M
------
I
G
G
A
I
F
-
F
A
G
M
L
V
M
A
Y
N
T
W
R
T
V
Q
A
A
K
P
A
E
Y
D
A
A
-----------------------------
14
HHSearch
46.06
17%
-225
- C- -
3B5D
1
EMRE_ECOLI
A:
[30-105]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
P
S
V
G
T
I
I
C
Y
C
A
S
F
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
-------------
A
Y
A
I
W
S
G
V
G
--------
I
V
L
I
-----
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
-----------
P
A
I
I
G
M
M
L
I
C
A
G
V
L
-
I
I
N
L
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
Fugue
41.03
35%
341
- C3 -
2PBD
-
V:
[1-37]
-------------------------------------------------------------------------
G
P
P
P
A
P
P
---------
L
P
A
A
A
P
G
L
A
A
A
I
A
G
A
K
L
R
K
-------
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
Fugue
37.42
25%
216
- C3 -
1ZTO
-
?
?:
[1-36]
------------------------------------------------------------------------------------
M
E
V
A
M
V
S
A
E
S
S
G
C
N
S
H
M
P
Y
G
Y
A
A
Q
-------
A
R
A
R
E
R
E
R
L
----
A
H
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
Fugue
36.77
15%
-18
- C3 -
1AUA
-
?
?:
[1-93]
----------------------------------------------------------------
Q
Q
E
K
E
F
L
E
S
Y
P
Q
N
C
P
P
D
A
L
P
G
T
P
G
N
L
D
S
A
Q
E
K
A
L
A
E
L
R
K
L
L
E
D
A
GFIERLD
D
S
T
L
L
R
F
L
R
----
A
R
K
F
D
V
Q
L
A
K
E
M
F
E
N
C
E
K
W
R
K
D
----------
Y
G
T
D
T
I
L
Q
D
F
H
Y
D
E
K
----
P
L
I
A
K
F
Y
P
Q
Y
Y
H
K
T
D
K
D
G
R
-
P
V
Y
F
E
E
L
G
A
V
N
L
H
E
M
N
K
V
T
S
E
E
R
M
L
K
N
L
V
W
E
Y
E
S
V
V
Q
Y
R
L
P
A
C
S
R
-------------
A
A
-
G
H
L
V
E
T
--------
S
C
T
I
-----
M
D
L
K
G
I
S
I
S
S
A
Y
S
V
-----------
M
S
Y
V
R
E
A
S
Y
I
S
Q
N
Y
-
Y
P
E
R
M
G
K
--------
F
Y
I
I
---------
N
A
P
F
G
F
S
T
A
F
R
L
F
K
P
F
L
D
P
----------
V
T
V
S
K
I
F
---
I
L
G
S
S
Y
Q
K
E
L
L
K
Q
I
P
A
E
N
L
P
V
K
F
G
G
K
S
E
V
D
E
S
K
G
G
L
Y
L
S
D
I
G
P
W
R
D
P
K
Y
I
G
P
E
G
E
A
P
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
2
Fugue
35.61
18%
297
- C3 -
2JPW
-
TNNI3_MOUSE
A:
[1-32]
---------------------------------------------------------------
M
A
D
E
S
S
D
A
A
G
E
P
Q
P
A
P
A
P
V
R
R
R
S
S
A
N
Y
R
A
Y
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
30.40
5%
-169
- C- -
3B5D
1
EMRE_ECOLI
A:
[32-105]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
V
G
T
I
I
C
-----
Y
C
A
S
-
F
W
------
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
I
G
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
-----------------------------------------------------------------------------------
4
Fugue
29.03
16%
447
- C3 -
4UI9
-
?
U:
[1-24]
--------------------------------------------------------------
M
S
R
R
P
C
S
C
A
L
R
P
P
A
A
A
A
A
A
A
A
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
26.39
11%
301
* C3 *
2ZXE
-
?
G:
[25-42]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
A
A
V
L
C
V
I
G
I
I
I
L
L
A
G
K
-----------------------------------------------------------------------------------
15
HHSearch
24.93
13%
602
- C2 -
2LOX
-
B:
[22-41]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
V
L
S
E
E
L
F
E
D
V
P
T
K
S
Q
I
S
--------------------------------------
18
HHSearch
22.34
11%
227
- C3 -
2JO1
-
PLM_HUMAN
A:
[22-39]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
A
G
I
L
F
I
L
G
I
L
I
V
L
S
R
R
C
R
C
K
F
N
Q
Q
Q
R
T
G
E
P
D
------
E
E
E
G
T
F
R
S
S
I
R
R
L
S
T
R
R
R
--------------------------------------------
16
HHSearch
20.79
13%
1385
- C1 -
2LI5
-
ATG7_YEAST
B:
[622-629]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
E
S
D
E
I
---------------------------
7
Fugue
20.41
24%
258
- C3 -
2QXV
-
EZH2_MOUSE
B:
[40-68]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
F
S
S
N
R
Q
K
I
L
E
R
T
E
T
L
N
Q
E
W
K
Q
R
R
I
Q
P
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------