@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35F6_HUMAN: (2015-12-10 )
MAWTKYQLFLAGLMLVTGSINTLSAKWADNFMAEGCGGSKEHSFQHPFLQAVGMFLGEFSCLAAFYLLRCRAAGQSDSSVDPQQPFNPLLFLPPALCDMTGTSLMYVALNMTSASSFQMLRGAVIIFTGLFSVAFLGRRLVLSQWLGILATIAGLVVVGLADLLSKHDSQHKLSEVITGDLLIIMAQIIVAIQMVLEEKFVYKHNVHPLRAVGTEGLFGFVILSLLLVPMYYIPAGSFSGNPRGTLEDALDAFCQVGQQPLIAVALLGNISSIAFFNFAGISVTKELSATTRMVLDSLRTVVIWALSLALGWEAFHALQILGFLILLIGTALYNGLHRPLLGRLSRGRPLAEESEQERLLGGTRTPINDAS
Atome Classification :
(19 SA)
--.......-------------..10........-20........30........40....-----....50........60........70........80........90....-----------------------....100..-.....110......-.120.......130.......140...-------..------------..150.......160..-..----...170.......---180.......190.....--------.---------.200........--.-210....--...---220......---.---230.......-240.......250----......-.260...--.....270..---.....280-......---..290-.-......300-......-----..310.------.....---------------------.320.......330.....-..340.....---..-350.......360.......370---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MAW
T
K
Y
Q
-------------
L
F
L
A
G
L
M
L
VTGS-IN
T
L
S
A
K
W
A
D
N
F
M
AEGCGGSKEHSFQ-----
H
P
F
L
Q
A
V
G
M
F
L
G
E
F
S
C
L
A
A
F
Y
L
L
R
C
RAAGQSDSSVDPQQPFN
P
L
L
FLP
P
A
-----------------------
L
CDMTGT
S
L
-
M
Y
V
A
L
NMTSA
S
S
F
Q
-
M
L
R
G
A
V
I
I
F
T
G
L
F
S
V
A
F
L
G
R
R
L
V
L
S
Q
W
-------
L
G
------------
I
L
A
T
I
A
G
L
V
V
V
G
L
A
D
L
L
-
S
K----HD
S
Q
H
K
L
S
E
V
ITG---
D
L
L
I
I
M
A
Q
I
I
V
A
I
Q
M
V
L
E
--------
E
---------
K
F
--VYKHNVH
P
--
L
-
R
AVGTE
G
--
L
F
G
---
F
V
I
L
S
L
L
L
V
---
P
---
M
Y
Y
IPAGSFS-GNPRG
T
L
E
D
A
L
D
A
----
F
C
QVGQ-Q
P
L
-
I
A
V
--
A
L
LGN
I
S
S
I
A
---
F
F
NFAG
I
--
S
V
T
K
E
L
---
S
A
T
T
R
-
M
-
V
L
D
S
L
R
T
V
--
V
I
W
A
L
S
-----
L
A
L
G
W
E
------
A
F
H
A
L
---------------------
Q
I
L
G
F
L
I
L
L
I
G
T
A
L
YNGL
H
-
R
P
L
L
G
R
LSRG---RP-LA
E
E
S
E
Q
E
R
LLGGTRTPINDAS----
20
Fugue
87.07
19%
-107
- C4 -
4Y97
-
DPOA2_HUMAN
A:
[157-598]
------
P
S
Q
-------------
K
Y
N
S
R
---
S
N
R
G
-
E
V
V
T
S
F
G
L
A
Q
G
V
S
W
S
G
R
G
G
A
G
N
I
S
L
K
V
L
G
C
P
E
A
L
T
G
S
Y
K
S
M
F
Q
K
L
P
D
I
R
E
V
L
T
C
K
I
E
E
L
G
S
E
L
K
E
H
Y
K
I
E
A
F
T
P
L
L
A
P
A
Q
E
P
V
T
L
L
G
Q
I
G
C
DSNGKLNNKS
V
I
L
E
G
D
R
E
H
S
S
G
-
A
Q
I
P
V
D
L
S
E
L
K
E
Y
S
-
L
F
P
G
Q
V
V
I
M
E
G
I
N
T
T
---
G
R
K
L
V
A
T
K
L
-------
Y
E
G
VPLP
F
Y
Q
P
T
E
E
D
A
D
F
E
Q
S
M
V
L
V
A
C
G
P
Y
T
-
T
S
DSIT
Y
D
P
L
L
D
L
I
A
V
I
N
H
D
RP
D
V
C
I
L
F
G
P
F
L
D
A
K
H
E
Q
V
E
N
CLLTSP
F
E
---------
D
I
--
F
K
Q
C
L
R
T
I
--
I
-
E
G
T
R
S
S
G
--
S
H
L
---
V
F
V
P
S
L
R
D
V
HHE
P
---
V
Y
P
Q
P
P
F
S
Y
S
-
D
L
S
R
---
E
D
K
K
Q
-----
V
Q
F
V
S
E
-
P
C
S
-
L
S
I
NG
V
I
F
G
L
T
S
T
D
L
---
L
F
H
L
G
A
E
--
E
I
S
S
S
S
GTS
D
R
F
S
R
-
I
-
L
K
H
I
L
T
Q
R
--
S
Y
Y
P
L
Y
PPQED
M
A
I
D
Y
E
------
S
F
Y
V
Y
AQLPVTPD
V
L
I
I
P
S
EL
R
Y
F
V
K
D
V
L
G
C
V
C
V
N
P
G
R
-
L
T
K
G
Q
V
-
G
G
T
F
A
R
L
Y
L
R
---
R
P
-
A
A
D
G
A
E
R
Q
-------
S
P
C
I
A
V
Q
V
V
R
I
19
Fugue
68.19
14%
-61
- C4 -
2YIJ
-
DSEL_ARATH
A:
[19-417]
FA
K
R
W
R
D
L
S
GQNHWKGMLQPLD
Q
D
L
R
E
Y
I
I
H
Y
G
E
M
A
Q
A
G
Y
D
T
F
N
I
N
T
E
S
Q
F
A
G
A
S
I
Y
S
--
R
-----
K
D
F
F
A
K
V
G
L
E
I
A
H
P
Y
--
T
K
Y
K
V
T
K
F
I
Y
A
T
S
D
I
H
V
--------
P
E
S
F
L
L
F
P
-----------------------
I
S
W
S
K
E
S
N
W
M
G
Y
V
A
V
T
D
D
Q
G
T
A
L
L
-
G
R
R
D
I
V
V
S
W
R
G
--
S
V
Q
P
F
E
F
G
L
V
N
A
I
K
-------
I
F
------------
G
E
R
N
D
Q
V
Q
I
H
Q
G
W
Y
S
I
Y
M
S
Q
----
D
E
R
S
P
F
T
K
T
N
A
R
D
---
Q
V
L
R
E
V
G
R
L
L
E
K
Y
K
---
D
--------
E
---------
E
V
--
S
I
T
I
C
G
H
S
--
L
G
A
A
L
A
T
L
S
--
A
T
D
---
I
V
A
N
G
Y
N
R
P
---
K
SRP
D
K
S
C
P
V
T
A
F
V
F
A
S
P
R
V
G
D
S
D
F
R
K
L
----
F
S
G
L
E
D
-
I
R
V
-
L
R
T
--
R
N
L
P
D
V
I
P
I
Y
PPI
G
Y
S
E
V
G
D
--
E
F
P
I
D
T
---
R
K
S
P
Y
M
K
-
S
P
G
N
L
A
T
F
H
C
L
E
G
Y
L
H
-----
G
V
A
G
T
Q
GTNKA
D
L
F
R
L
D
---------------------
V
E
R
A
I
G
L
V
N
K
S
V
D
G
L
K
D
E
C
M
V
P
G
K
W
R
V
L
K
N
---
K
G
M
A
Q
Q
D
D
G
S
W
E
L
V
D
H
E
I
D
D
N
E
D
L
-----
16
Fugue
64.98
13%
-127
- C2 -
1L9V
-
NSP2_ROTSR
A:
[1-313]
--
M
A
E
L
A
C
---------------------------------------------------
F
C
-----
Y
P
H
L
E
N
D
S
Y
K
F
I
P
F
N
N
L
A
I
K
A
M
L
T
--
A
K
V
D
K
K
D
M
D
K
F
Y
D
S
I
I
Y
G
I
A
P
P
P
Q
-----------------------
F
K
K
R
Y
N
T
N
D
-
N
S
R
G
M
N
F
E
T
----
I
-
M
F
T
K
V
A
M
L
I
C
E
A
L
N
----
S
L
K
V
T
Q
A
N
V
-------
S
N
------------
V
L
S
R
V
V
S
--
I
R
H
L
E
N
L
V
-
I
R
----
K
E
N
P
Q
---
D
I
L
F
H
---
S
K
D
L
L
L
K
S
T
L
I
A
I
G
Q
S
K
E
--------
I
E
T
TITAEGG
E
I
--
V
F
Q
N
A
A
F
T
--
M
-
W
K
L
T
Y
L
E
HQ
L
M
P
---
I
L
D
Q
N
F
I
E
Y
---
K
---
V
T
L
N
E
D
K
P
I
S
-
D
V
H
V
K
E
L
V
A
E
L
R
W
QYNK
F
A
V
I
T
H
G
K
G
H
-
Y
R
I
--
V
K
Y
S
S
V
A
N
H
A
---
D
R
V
Y
A
T
F
--
K
S
N
V
K
T
---
G
V
N
N
D
-
F
---
N
L
L
D
Q
R
--
I
I
W
----------
Q
N
W
Y
------
A
F
T
S
S
---------------------
M
K
Q
G
N
T
--------
L
D
V
C
K
-
R
L
L
F
Q
K
M
K
P
E
---
K
N
-
P
F
K
G
L
S
T
D
R
K
M
D
E
V
S
-----------
23
Fugue
52.42
12%
-128
* C4 *
1YE8
-
NTPTH_AQUAE
A:
[2-178]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
I
T
G
---
E
P
G
V
G
K
T
T
L
V
K
K
I
V
E
R
L
G
--------
K
---------
R
A
I
G
F
W
T
E
E
V
R
R
T
G
F
-
R
I
I
T
T
E
G
--
K
K
K
---
I
F
S
S
K
F
F
T
S
---
K
---
K
L
V
G
S
Y
G
V
N
V
-
Q
Y
F
E
E
L
A
I
P
I
L
E
R
----
A
Y
R
E
A
K
-
K
D
R
-
R
K
V
--
I
I
I
D
E
I
G
K
M
E
---
L
F
S
K
K
F
R
--
D
L
V
R
Q
I
M
--
H
D
P
N
V
-
N
-
V
V
A
T
I
P
I
R
D-
V
H
P
L
V
K
-----
E
I
R
R
L
P
------
G
A
V
L
I
---------------------
E
L
T
P
E
N
R
D
V
I
L
E
D
I
L
S
L
L
E
-
R
-----------------------------------------
8
HHSearch
44.43
21%
-150
- C- -
3B5D
1
EMRE_ECOLI
A:
[30-105]
------------------------------------------------------------------------------------------------------------
L
W
P
S
V
G
T
I
-----------------------
I
C
Y
C
A
S
F
W
L
-
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
-------
I
G
------------
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
41.36
26%
-196
- C- -
3B61
-
EMRE_ECOLI
A:
[59-110]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
A
-
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
-------
I
G
------------
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
R
S
-
T
P
----
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
37.69
26%
-158
- C- -
3B5D
-
EMRE_ECOLI
A:
[59-105]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
A
-
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
-------
I
G
------------
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
37.00
8%
-75
- C3 -
4OY2
-
TAF7_YEAST
B:
[2-230]
-------------------------------------------------------------------------------
L
R
L
K
P
I
R
I
P
G
E
A
Y
D
S
E
A
S
D
I
E
D
D
P
L
I
E
S
G
V
I
L
R
I
L
P
D
-----------------------
I
Q
L
E
F
V
K
N
S
-
L
E
S
G
D
Y
S
G
I
S
I
K
W
K
-
N
E
R
H
A
V
V
T
I
N
D
V
Y
G
A
I
L
V
D
L
P
T
V
I
E
V
N
K
S
V
DRKN
L
L
------------
K
T
F
D
V
S
Q
L
L
C
I
R
--
P
I
Q
-
E
E
----
E
E
V
Y
A
L
E
A
P
D
T
E
D
---
L
V
V
K
H
F
E
G
I
E
D
E
I
W
E
N
K
E
--------
T
---------
F
L
--
K
G
Y
N
G
A
P
L
--
S
-
D
E
A
K
H
L
K
--
E
I
A
L
K
G
Y
D
Y
K
H
G
I
S
P
---
P
---
L
Y
N
V
R
N
R
R
F
R
-
R
K
D
P
N
E
I
D
Y
V
E
K
V
----
V
D
L
L
K
Q
-
D
K
Q
-
A
E
E
--
V
S
Y
D
L
V
D
K
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
36.15
14%
-151
- C- -
3B5D
1
EMRE_ECOLI
A:
[31-105]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
P
-
S
V
G
--
T
I
I
C
Y
C
A
S
F
W
---
L
L
A
Q
T
------
L
A
Y
I
---
P
T
G
I
A
-
Y
A
I
W
S
G
V
G
I
V
--
L
I
S
L
L
S
-----
W
G
F
F
G
Q
------
R
L
D
L
P
---------------------
A
I
I
G
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
-------------------------------------------
5
PsiBlast_PDB
35.21
26%
-130
- C- -
3B62
-
EMRE_ECOLI
A:
[59-101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
A
-
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
-------
I
G
------------
M
M
L
I
C
A
G
V
L
I
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
26.73
33%
270
* C5 *
2RMI
-
?
A:
[13-41]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
L
-
R
E
V
L
E
--
A
R
A
---
E
Q
-
L
A
Q
E
A
H
K
N
R
K
L
E
I
I
------------
14
Fugue
26.56
19%
296
- C1 -
1SUY
-
KAIC_THEEB
C:
[401-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
A
G
I
I
S
G
T
PTR
I
S
-
V
D
E
K
T
E
L
A
R
I
A
K
G
M
Q
D
L
E
S
E
------
2
PsiBlast_PDB
25.12
23%
-8
- C5 -
2I68
-
EMRE_ECOLI
A:
[59-104]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
A
-
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
------
A
I
-------
I
G
------------
M
M
L
I
C
A
G
V
L
I
I
N
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
25.09
33%
54
- C5 -
4WZH
2
?
A:
[35-77]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
L
Q
V
--
G
I
L
G
N
T
F
A
N
P
---
F
M
N
A
A
G
V
MC
S
T
E
E
E
L
---
A
A
M
T
E
-
S
-
T
S
G
S
L
I
T
K
--
S
C
T
P
A
L
-----
R
E
G
N
P
A
------
P
R
Y
Y
T
---------------------
L
P
L
G
S
I
N
S
M
G
L
P
N
K
G
F
D
F
Y
-
L
A
Y
S
A
R
H
H
D
Y
---
S
R
-
K
P
L
F
I
S
I
S
G
F
S
A
E
E
N
A
E
M
C
K
R
L
----
17
Fugue
16.45
35%
344
- C5 -
2W84
-
B:
[1-20]
-------------------------------
G
V
A
-
D
L
A
L
S
E
N
W
A
Q
E
F
L
A
A
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
13.21
20%
139
- C5 -
3GIA
3
Y609_METJA
A:
[401-425]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
-
R
K
V
T
K
R
T
F
S
N
---
N
M
-
Y
V
K
S
----------------------
13
HHSearch
6.75
6%
236
- C5 -
2JO1
-
PLM_HUMAN
A:
[23-39]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
G
I
L
F
I
L
G
I
L
I
V
L
S
R
R
-
C
R
C
K
F
N
Q
Q
Q
R
---
T
G
-
E
P
D
E
E
E
G
T
F
R
S
S
I
R
R
L
S
T
R
R
R
-----
10
HHSearch
5.31
10%
301
- C5 -
2ZXE
-
?
G:
[26-42]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
A
V
L
C
V
I
G
I
I
I
L
L
A
G
K
-------------------------------------------
12
HHSearch
5.26
28%
278
- C5 -
2JP3
-
FXYD4_RAT
A:
[24-41]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
G
L
L
C
I
A
G
I
A
L
A
L
S
G
K
-
C
K
C
R
R
N
H
T
P
S
---
S
L
-
P
E
K
V
T
P
L
I
T
P
G
S
A
S
T
-----------