@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S36A1_HUMAN: (2015-12-10 )
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
Atome Classification :
(13 SA)
------.........10----........20...-.....30........40........50........60...-.-....70---........80.....------------------...90........100.......110.......120-........130----------.........-140.......-150.....---------..--160.......170.......180..-.....190.......200......------.210.....--------..220-........230--.......240..---..--------...250-----.------------------.--...------....260-.---......270..---...-----..------.280..-.-...-.290.......300....-----...310..--------.....320--.-------...---.....---330...---------....340.......350..-------------.....360.......370-----.........380.......390...---.--------------------------...400.....--..410.......----420----.......430.......440.......450.......-460.......----470....----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------M
S
T
Q
RLRNEDY----HDYSSTDVSPEE
S
-
P
S
EGLNNLSSPG
S
Y
Q
RFGQSNS
T
T
W
F
Q
T
L
I
H
L
L
KGNIGTG-L-LGL
P
L
A
---VKNA
G
I
V
M
G
P
I
S
L
L
I
------------------
I
G
I
V
A
V
H
C
M
G
I
L
V
K
C
A
H
H
F
C
R
R
L
N
K
S
F
VDYGD
T
V
M
--YGLESS
P
C
S
------------
W
L
R
N
H
A
H
W
G
-
R
R
V
V
D
F
F
L
I
V
-
T
Q
L
G
F
C
C
V
---------
Y
F
--
V
F
L
A
D
N
F
K
Q
V
I
E
AANGTTNNCHNN
E
-
T
V
I
L
TPTMDS
R
L
Y
M
L
S
F
L
P
F
L
V
L
L
------
V
F
I
R
N
L
R
A
L
--------
S
I
F
S
--
L
L
A
N
I
T
M
L
V
S
L
--
V
M
I
Y
Q
F
I
V
Q
RIP---DP--------SHL
P
-------
L
------------------V--APW------KT
Y
P
L
F
F
-
G
---
T
A
I
FSFE-G
I
G
---
M
V
L-----PL------ENKMKD-P-RKF-
P
L
I
L
Y
L
G
M
V
I
V
T
I
L
Y
I
S
L
-----
G
C
L
G
Y
L
Q
F--------GANI
Q
G
----
S
-------
I
T
L---NLP
N
C
---
W
L
Y
Q
S
V
---------
K
L
L
Y
S
I
G
I
F
F
T
Y
A
L
Q
F
YV
P
-------------
A
E
I
I
I
P
F
F
V
SRAP
E
H
C
-------
E
L
V
V
D
L
F
V
R
T
V
L
V
C
L
T
C
I
L
A
I
L
I
P
R
---
L
--------------------------
D
L
V
I
S
L
V
G
S
VS--S
S
A
L
A
L
IIP
P
L
L
----
E
V
T
----
T
F
Y
SEGM
S
P
L
T
I
F
K
D
A
L
I
S
I
L
G
F
V
G
F
V
V
G
T
Y
E
A
L
Y
E
L
-IQPSNA
P
I
F
I----NSTCAFI----------------
18
Fugue
91.16
18%
-124
* C2 *
4US3
11
?
A:
[10-450]
------------
G
R
E
Q
W
----
A
-------
S
R
L
G
F
-
I
L
A
A
M
G
S
A
V
G
L
G
N
I
W
R
F
S
Y
V
T
G
E
N
------------------------------------
G
G
A
A
F
L
L
------------------
V
Y
L
G
F
I
A
L
I
G
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P
I
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R
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A
Q
S
-----
D
A
V
G
--
S
F
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K
L
A
P
G
K
------------
P
W
K
V
A
G
L
M
G
-
V
A
A
G
--
F
L
I
L
-
S
F
Y
G
V
I
A
G
---------
W
I
--
L
F
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L
F
N
Y
I
T
G
Q
L
W
S
A
P
A
E
G
F
G
G
F
F
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-
G
F
I
A
N
P
T
L
-
P
L
F
W
Q
A
L
F
M
I
A
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I
W
I
------
V
A
I
G
V
K
K
G
I
--------
E
R
S
N
K
I
L
M
P
L
L
G
V
L
L
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--
L
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T
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G
G
A
K
---
E
G
--------
L
A
F
L
-------
F
------------------
S
--
P
D
W
SALKD
P
G
V
Y
L
A
A
I
-
S
---
Q
A
F
F
T
L
S
L
G
M
G
---
A
L
I
-----
T
Y
G
S
Y
VSK
D
S
R
L
P
G
-
A
-
A
V
S
-
V
A
G
L
D
T
A
F
A
I
I
A
G
I
M
I
F
P
-----
A
V
F
A
L
G
L
S
--------
P
S
G
G
P
G
----
L
-------
V
F
V
---
V
L
P
D
-----
I
F
D
S
I
---------
R
L
G
P
I
V
G
I
A
F
F
I
L
L
G
A
A
A
L
-------------
S
S
A
V
S
L
L
E
V
P
V
A
Y
F
M
R
-------
K
F
--
D
W
S
R
K
Q
A
A
I
T
L
G
V
I
I
T
L
L
G
I
P
---
S
--------------------------
S
L
S
F
G
V
L
G
E
V
T
--------
I
I
P
G
L
N
----
I
F
D
----
S
V
D
F
I
A
S
S
--
V
F
L
P
L
G
G
M
I
I
A
L
F
I
G
W
G
W
K
T
S
D
A
L
A
E
S
D
L
T
D
S
V
W
G
K
L
W
----
I
L
S
L
R
F
I
A
P
I
A
I
L
I
V
F
L
S
A
F---
12
Fugue
75.04
11%
-141
- C2 -
3GIA
7
Y609_METJA
A:
[3-435]
----------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
-
I
-
F
---------------------
S
I
------------------
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
--
K
-
I
V
S
N
A
G
P
------------
I
A
F
I
H
K
A
I
G
-
D
N
I
I
T
G
A
L
S
I
-
L
L
W
M
S
Y
V
I
---------
S
I
--
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
-------------
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
------
L
N
F
F
G
S
K
A
V
--------
G
R
A
E
--
F
F
I
V
L
V
K
L
L
I
L
--
G
L
F
I
F
A
G
L
I
T
I
H
---
P
S
--------
Y
V
I
P
-------
D
------------------
L
--
A
P
S
------
A
V
S
G
M
I
F
-
A
---
S
A
I
F
F
L
S
-
Y
M
G
F
G
V
I
T
N
-----
A
S
------
E
H
I
E
N
P
-
K
-
K
N
V
-
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
--------
I
K
A
S
E
N
----
A
-------
L
A
V
---
A
A
K
P
F
LG
N
L
G
F
L
L
I
---------
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
-------------
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
-------
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
FN
M
--------------------------
E
G
V
A
S
I
T
S
A
V
F
--
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
ID
E
V
G
----
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
-
T
F
I
G
V
L
I
F
E
I
----
I
Y
R
K
V
T
K
R
T
F
S
NNMYVKS-----
14
Fugue
74.81
18%
-131
- C1 -
4UIR
2
OLHYD_ELIME
A:
[2-646]
NPITSK
F
D
K
V
L
N
A
S
S
E
Y
GHVN
H
E
P
D
S
S
K
E
Q
Q
R
N
T
-
P
Q
K
S
M
P
F
S
D
Q
I
G
N
Y
Q
R
N
K
G
I
P
V
Q
S
Y
D
N
S
K
I
Y
I
I
----
G
S
G
-
I
-
A
G
M
S
A
A
Y
Y
F
I
R
D
G
H
V
P
A
K
N
I
T
F
L
E
QLHIDGGSL
D
G
A
G
N
PTD
G
Y
I
I
R
G
G
R
E
M
D
M
T
Y
E
N
L
W
D
M
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Q
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A
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P
A
P
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S
V
L
D
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Y
R
L
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N
D
N
D
S
N
Y
S
KARLINNK
G
E
I
K
D
F
S
K
F
G
-
L
N
K
M
D
Q
L
A
I
I
-
R
L
L
L
K
N
K
E
ELDDLTIED
Y
F
S
E
S
F
L
K
S
N
F
W
T
F
W
R
T
M
F
A
F
E
N
W
H
S
L
L
E
-
L
K
L
Y
M
H
R
F
L
H
A
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D
G
L
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D
L
S
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L
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KYNQYD
T
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L
D
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H
I
N
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K
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V
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G
I
I
T
E
Q
D
G
---
K
E
--------
V
K
I
P
-------
V
G
KN
D
Y
V
I
V
TTGSMTED
T
F
Y
--
G
N
N
------
K
T
A
P
I
I
G
-
I
---
D
N
S
T
S
G
Q
-
S
A
G
---
W
K
L
W
K
N
L
A
A
K
------
S
E
I
F
G
K
-
P
-
E
K
F
C
S
N
I
E
K
S
A
W
E
S
A
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L
T
C
K
P
S
-----
A
L
I
D
K
L
K
E
Y
SVNDPYS
G
K
T
V
T
G
----
G
-------
I
I
T
---
I
T
D
S
N
---
W
L
-
M
S
F
T
C
N
RQPHFP
E
Q
P
D
D
V
L
V
L
W
V
Y
A
L
F
M
D
K
E
GNYIKKTMLECT
G
D
E
I
L
A
E
L
C
Y
H
L
G
I
E
D
Q
-------
L
E
N
V
Q
K
N
T
I
V
R
T
A
F
M
P
Y
I
T
S
M
F
M
P
R
---
A
KGD
R
P
R
VVPEGCKN
L
G
L
V
G
QFVETN
N
D
V
V
F
T
M
E
S
S
V
R
--
T
A
R
I
A
V
Y
K
L
L
N
L
----
N
K
Q
V
P
D
I
N
P
L
Q
Y
D
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R
H
L
L
K
A
A
K
T
L
N
D
D
K
P
F
V
G
------
E
G
L
L
R
K
-
V
L
K
G
T
Y
F
E
H
V
LPAG
E
E
H
E
S
F
I
A
E
H
V
N
K
F
R
E
W
V
K
G
IRG
1
HHSearch
74.42
11%
-146
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-379]
------------------------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
-
V
-
F
L
L
P
A
N
---
L
A
S
T
G
G
-
I
A
I
Y
G
W
L
V
------------------
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
--
P
G
G
S
Y
A
Y
A
R
----------------------------
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
-
A
C
W
I
G
N
I
A
---------
M
V
--
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
-----------------
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
------
L
N
I
V
G
P
K
M
I
--------
T
R
V
Q
--
A
V
A
T
V
L
A
L
I
P
I
--
V
G
I
A
V
F
G
W
F
W
F
R
---
G
E
--------
T
Y
M
A
---------------------------------------
A
I
Q
S
T
L
-
N
---
V
T
L
W
S
F
I
-
G
V
E
---
S
A
S
-----
V
A
------
A
G
V
V
K
N
-
P
K
R
N
V
-
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
-----
T
T
A
I
M
G
M
I
--------
P
N
A
A
L
R
----
V
SASP
F
G
D
A
A
R
---
M
A
L
G
D
---
T
A
G
A
I
V
---------
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
-------------
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
FARVNKA
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
---
A
--------------------------
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
----
L
L
L
----
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
-
W
S
F
V
T
L
M
V
I
T
----
A
M
Y
A
L
N
Y
----------------
2
HHSearch
66.37
11%
-142
- C2 -
3GIA
5
Y609_METJA
A:
[3-307]
----------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
-
I
-
F
S
I
F
G
V
G
--
A
K
I
A
G
R
-
N
L
P
E
T
F
I
L
------------------
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
--
N
A
G
P
I
A
F
I
H
----------------------------
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
-
S
Y
V
I
S
I
A
L
---------
F
A
--
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
----------------
T
-
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
------
L
N
F
F
G
S
K
A
V
--------
G
R
A
E
--
F
F
I
V
L
V
K
L
L
I
L
--
G
L
F
I
F
A
G
L
I
T
I
H
---
P
S
--------
Y
V
I
P
DL-----
A
------------------
P
--
S
A
V
------
S
G
M
I
F
A
S
-
A
---
I
F
F
L
S
Y
M
-
G
F
G
---
V
I
T
-----
N
A
------
S
E
H
I
E
N
-
P
K
K
N
V
-
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
-----
A
I
S
A
I
G
N
L
--------
P
I
D
E
L
I
K
A
SE
N
A
------
L
A
V
A
A
K
P
F
L
G
N
---
L
G
F
L
L
I
---------
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
-------------
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
-------
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
---
L
--------------------------
F
N
M
E
G
V
A
S
I
T
S
--
A
V
F
M
V
I
Y
L
F
V
I
L
----
S
H
Y
----
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
-
V
F
Y
G
I
I
A
T
F
I
----
G
V
L
I
F
E
I
----------------
15
Fugue
64.80
13%
-115
- C1 -
4WID
1
?
A:
[10-362]
---------
K
D
M
A
L
Q
H
A
----
V
D
L
L
E
K
M
L
A
D
E
E
K
-
L
T
E
--
F
N
L
G
D
P
-----
L
F
E
S
A
N
D
D
P
I
K
T
L
E
E
I
I
Q
E
--
G
D
D
----------------------------------------------------
V
V
G
A
H
Q
L
V
V
T
Q
I
K
L
R
V
Q
R
N
R
R
L
A
D
E
I
I
R
--
E
Q
L
T
D
I
R
K
V
------------
F
S
D
K
F
E
K
L
E
-
Q
G
I
Q
N
S
Y
L
L
L
-
D
K
L
K
---
T
---------
P
F
--
Q
D
M
R
C
L
F
E
V
A
N
E
Q
F
N
D
T
P
V
P
P
Q
Y
K
E
F
M
V
C
L
K
Q
I
V
Q
Y
A
V
N
S
S
S
L
E
K
F
V
M
L
I
------
T
K
K
D
D
I
K
D
R
--------
V
T
Y
T
--
C
M
K
Y
L
L
M
A
M
Q
G
--
T
G
G
P
K
----
A
I
N
---
N
E
--------
E
H
A
K
-------
L
------------------
F
--
F
Q
L
------
S
N
Y
D
----
D
---
L
T
D
A
N
H
D
-
G
L
E
---
L
I
K
-----
K
L
------
D
K
E
Q
K
E
V
A
-
F
H
V
-
N
N
F
T
H
L
V
T
T
L
G
M
A
L
Y
--------------
K
E
--------
G
H
Q
K
N
D
----
E
-------
A
M
L
---
G
M
------------------------------
H
T
P
I
T
M
L
S
D
Q
-------------
V
R
V
L
I
L
Y
L
I
D
E
I
V
H
A
I
-------
H
T
N
S
N
Q
S
N
D
E
L
I
D
G
L
K
P
K
V
R
I
V
I
N
E
---
F
--------------------------
H
A
T
L
M
M
-----------------------------------
G
I
D
K
M
K
F
Y
----------------
S
L
N
E
L
R
E
I
-
V
N
D
K
I
--------------------------------
4
HHSearch
29.27
10%
-105
- C2 -
2JLN
-
?
A:
[21-183]
---------------------------------------------------
R
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
-
I
F
I
A
A
G
Q
M
---
T
S
S
F
Q
V
W
Q
V
I
V
A
I
A
A
------------------
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
----
G
I
N
F
T
V
A
---
A
R
-------------------------
M
P
F
G
I
R
G
-
S
L
I
P
I
T
L
K
A
L
-
L
S
L
F
W
F
G
F
---------
Q
T
--
W
L
G
A
L
A
L
D
E
I
T
R
L
L
T
G
F
----------------
T
N
L
P
L
W
I
V
I
F
G
A
I
Q
V
V
T
------
T
-
F
Y
G
I
T
F
I
--------
R
W
M
N
--
V
F
A
S
P
V
L
L
A
M
G
--
V
Y
M
V
Y
L
M
L
D
G
A
D
---
V
S
--------
L
G
E
V
-------
M
------------------
S
--
M
G
G
------
E
N
P
G
M
P
F
-
S
---
T
A
I
M
I
F
V
-
G
G
W
---
I
A
V
-----
V
V
------
S
I
H
D
I
V
-
K
-
E
C
K
-
V
D
P
N
A
S
R
E
G
Q
T
K
A
D
A
R
Y
A
-----
T
A
Q
W
L
G
M
V
--------
P
A
S
I
I
F
----
G
-------
F
I
G
---
A
A
S
M
V
---
L
V
G
E
W
N
---------
P
V
I
A
I
T
E
V
V
G
G
V
S
I
P
M
A
I
L
-------------
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
A
A
-------
N
L
L
S
P
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
V
I
V
---
S
--------------------------
A
V
V
G
L
L
M
M
P
W
Q
--
F
A
G
V
L
N
T
F
L
N
L
L
----
A
S
A
----
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
R
I
S
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
G
-
V
N
W
V
A
L
A
V
Y
A
----
V
A
L
A
V
S
F
----------------
10
HHSearch
29.15
18%
-99
- C2 -
2A65
1
?
A:
[8-41]
--------------------------------------------------------
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
-
L
R
F
P
V
Q
---
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
------------------
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
--
W
R
N
R
F
A
K
I
L
------------
G
V
F
G
L
W
I
P
L
-
V
V
A
I
Y
Y
V
Y
I
E
-
S
W
T
L
G
F
A
I
---------
K
F
--
L
V
G
L
V
P
E
P
P
P
T
D
P
D
S
I
L
R
P
F
K
E
F
L
Y
-
S
Y
I
G
V
P
K
G
D
E
P
I
L
K
P
S
L
F
A
Y
I
V
F
L
------
I
T
M
F
I
N
V
S
I
--------
L
I
R
G
--
I
S
K
G
I
E
R
F
A
K
I
--
A
M
P
T
L
F
I
L
A
V
F
L
---
V
I
--------
R
V
F
L
-------
L
------------------
E
--
T
P
N
------
G
T
A
A
D
G
L
-
N
---
F
L
W
T
P
D
F
-
E
K
L
---
K
D
P
-----
G
V
------
W
I
A
A
V
G
-
Q
-
I
F
F
-
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
-----
D
Q
D
I
V
L
S
G
--------
L
T
A
A
T
L
----
N
-------
E
K
A
---
E
V
I
L
G
---
G
S
I
S
I
P
---------
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
A
-------------
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
-------
G
G
T
F
L
G
F
L
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
---
Q
--------------------------
P
M
I
A
F
L
E
D
E
L
K
--
L
S
R
K
H
A
V
L
W
T
A
A
----
I
V
F
----
F
S
A
H
L
V
M
F
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
-
W
I
F
G
A
D
K
A
W
E
----
E
I
N
R
G
G
I
----------------
3
HHSearch
28.63
9%
-92
- C2 -
3DH4
1
?
A:
[52-275]
-----------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
-
Q
F
I
G
M
S
G
S
---
G
Y
S
I
G
L
A
I
A
S
-
Y
E
W
M
------------------
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
G
---
I
Y
T
I
P
E
F
V
E
----------------------------
K
R
F
N
K
K
L
-
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
---------
V
L
--
Y
L
G
G
L
A
L
E
T
I
L
G
I
---------------------
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
------
S
I
------
V
--------
V
W
T
D
--
V
I
Q
V
F
F
L
V
L
G
G
--
F
M
T
T
Y
M
A
V
S
F
I
G
GTD
G
W
F
A
G
V
S
K
M
V
D
A
A
P
GHFEMIL
D
QSN---------------
P
QY
M
N
L
------
P
G
I
A
V
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
-
F
N
Q
---
Y
I
I
-----
Q
R
------
T
L
A
A
K
S
-
V
-
S
E
A
-
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
-----
V
L
P
G
I
A
A
Y
--------
V
I
T
S
D
P
----
Q
-------
L
M
A
---
S
L
G
D
I
---
A
A
T
N
L
P
---------
S
A
A
N
A
D
K
A
Y
P
W
L
T
Q
F
L
P
V
G
-------------
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
-------
L
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
---
G
--------------------------
D
H
K
L
V
N
V
G
R
T
A
--
A
V
V
A
L
I
I
A
C
L
I
A
----
P
M
L
----
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
K
-
G
A
I
I
G
V
V
A
S
I
----
P
F
A
L
F
L
K
----------------
9
HHSearch
26.36
16%
24
- C2 -
2WDQ
2
DHSD_ECOLI
D:
[66-109]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
L
I
H
-
A
W
I
---
G
M
W
-----
Q
V
------
L
T
D
Y
V
K
-
P
-
L
A
L
-
R
L
M
L
Q
L
V
I
V
V
A
L
V
V
Y
V
I
Y
-----
G
F
V
V
V
W
G
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
25.62
4%
-89
- C2 -
2WSW
-
?
A:
[87-112]
-----------------------------------------------------
E
K
P
E
F
S
T
A
S
W
I
F
M
M
F
A
S
C
T
S
A
A
-
V
-
L
F
W
G
S
I
---
E
I
Y
Y
Y
I
S
S
P
P
F
G
M
E
G
------------------
Y
S
A
P
A
K
E
I
G
L
A
Y
S
L
F
H
W
G
P
L
P
W
A
T
Y
S
F
L
S
V
A
F
A
Y
F
--
F
F
V
R
K
M
E
V
I
------------
R
P
S
S
T
L
V
P
L
-
V
G
E
K
H
V
N
G
L
F
-
G
T
V
V
D
N
F
Y
---------
L
V
--
A
L
I
L
A
M
G
T
S
L
G
L
A
T
P
L
V
T
E
C
I
Q
Y
L
F
-
G
I
P
H
T
L
Q
L
D
A
I
I
I
S
C
W
I
L
L
N
A
I
C
V
------
A
F
G
L
Q
K
G
V
K
--------
I
A
S
D
--
V
R
T
Y
L
S
F
L
M
L
G
--
W
V
F
I
V
G
G
A
S
F
I
V
---
N
Y
--------
F
T
D
S
-------
V
------------------
G
--
T
L
L
------
M
Y
M
P
R
M
L
-
F
---
Y
T
D
P
I
G
K
-
G
G
F
---
P
Q
A
-----
W
T
------
V
F
Y
W
A
W
-
W
-
V
I
Y
-
A
I
Q
M
S
I
F
L
A
R
I
S
K
G
R
T
V
R
-----
E
L
C
L
G
M
V
S
--------
G
L
T
A
G
T
----
W
-------
L
I
W
---
T
I
L
G
G
---
N
T
L
Q
L
I
---------
D
Q
N
I
L
N
I
P
Q
L
I
D
Q
Y
G
V
P
R
A
-------------
I
I
E
T
W
A
A
L
P
L
S
T
A
T
M
W
-------
G
F
F
I
L
C
F
I
A
T
V
T
L
I
N
A
C
S
Y
T
L
A
M
S
T
---
C
--------------------------
R
S
M
K
E
G
A
D
P
P
L
--
L
V
R
I
G
W
S
V
L
V
G
I
----
I
G
I
----
I
L
L
A
L
G
G
L
K
P
I
Q
T
A
I
I
A
G
G
C
P
L
F
F
V
N
I
M
V
T
L
S
F
I
K
D
A
-
K
V
H
W
K
--------------------------------
13
Fugue
25.35
14%
14
- C2 -
2LOW
-
APJ_HUMAN
A:
[1-64]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
E
G
G
D
F
D
N
Y
Y
G
A
-
D
N
Q
S
E
C
E
Y
T
D
W
K
S
S
G
A
L
I
P
A
I
Y
M
L
------
V
F
L
L
G
T
T
G
-----------------------
N
G
L
--
V
L
W
T
V
F
R
K
K
G
H
H
---
H
H
--------
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
21.25
19%
397
* C1 *
1G2Z
-
HNF1A_MOUSE
A:
[1-32]
----------------------
M
V
S
K
L
S
Q
L
Q
T
E
L
M
A
A
L
L
E
S
G
L
S
K
E
A
L
I
Q
A
L
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------