@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S38A2_HUMAN: (2015-12-10 )
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH
Atome Classification :
(20 SA)
---.........10........20........30........40........50........60........70........80......-.-.90...-.....-100.......110.......120..--.....130.....------...140..-----..-...150...-.------...160--........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350....----...360....--...370.......380.......390.......400....---------...410.......420.......430.......440....--...450.......460.......470.......480........490.......500....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MKKAEMG
R
F
SISPDEDSSSYSSNSDFNYSYP
T
K
Q
A
A
L
K
S
HYADVDPENQ
N
F
L
L
ESNLGKKKYETEFHPGTTSFG
M
S
V
F
NL
S
N
A
I
VG
S
-
G
-
I
L
G
L
S
Y
-
A
M
ANT-
G
I
A
L
F
I
I
L
L
T
F
V
S
I
F
S
L
Y
S
V
H
L
L
L
K
--TANEG
G
-
S
L
L
Y
E
Q
------L
G
Y
K
A
F
G
L
-----
V
G
-
K
LAASG
S
I
T
-
M
------
Q
N
IG-A--M
S
S
Y
L
F
I
V
K
YE
L
P
L
V
I
Q
A
L
TNIEDKT
G
L
W
Y
LNGN
Y
L
V
L
L
V
S
L
V
V
I
L
P
L
S
L
F
R
NLGYLG
Y
T
S
G
L
S
L
L
C
M
V
F
F
L
I
V
V
I
C
K
KFQVPCPV
E
A
A
L
I
I
NETINTTLTQP
T
A
L
V
P
A
LSHNVTENDSC
R
P
H
Y
F
I
FNSQ
T
V
Y
A
V
P
I
L
I
F
S
F
VC
H
P
A
V
L
P
I
Y
E
E
L
K
D
R
S
R
R
RMM
N
V
S
K
I
S
F
F
A
M
F
L
M
Y
L
L
A
A
L
F
G
Y
L
T
F
Y
E
H
V
E
S
----
E
L
L
H
T
Y
S
S
I
L
--
G
T
D
I
L
L
L
I
V
R
L
A
V
L
M
A
V
T
L
T
V
P
V
V
I
F
PIRSS
V
T
H
L
L
CASK---------D
F
S
W
W
R
H
S
L
I
T
V
S
I
L
A
F
T
N
L
L
V
I
F
V
P
T
I
R
D
I
F
G
F
I
G
A
S
A
A
--
S
M
L
I
F
ILPS
A
F
Y
I
K
L
V
K
KE
P
M
K
S
V
Q
K
I
G
A
L
F
F
L
L
S
-
G
V
L
V
MTG
S
M
A
L
I
V
L
D
W
VHNAPGGGH
24
Fugue
90.00
13%
-117
- C2 -
1BJ4
1
GLYC_HUMAN
A:
[1-470]
DA
D
L
W
S
S
H
D
A
M
L
A
Q
P
L
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
---
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
------------------
G
T
E
F
-
I
D
E
L
E
-
T
L
C
Q
K
R
A
L
Q
A
Y
K
L
D
P
Q
C
W
G
V
N
V
Q
P
Y
--
S
G
S
P
A
N
-
F
A
V
Y
T
A
------
L
V
E
P
H
G
R
I
-----
M
G
L
D
L
P
D
G
G
H
L
T
-
H
G
F
M
T
DK
K
K
I
S
-
A
--
T
S
I
F
F
E
S
M
P
Y
K
V
N
P
D
-
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
E
Y
A
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
A
A
G
V
V
--
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
K
G
V
K
S
V
D
P
A
T
------
G
K
E
I
L
Y
N
L
E
S
L
I
N
S
A
V
--------
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
----
A
L
T
E
L
G
Y
K
I
V
TG
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
-
C
P
G
---------
D
R
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
------------
G
L
L
E
K
D
F
Q
--
K
V
A
H
F
I
H
R
G
I
E
L
T
L
Q
I
Q
S
D
T
G
V
A
A
T
L
K
E
F
K
E
R
L
A
G
D
K
Y
Q
A
A
V
Q
A
L
R
E
E
V
E
S
F
A
S
L
F
P
L
P
G
L
6
HHSearch
77.64
12%
-137
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-380]
----------------------------------------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
-
G
-
V
F
L
L
P
A
-
N
L
A
S
T
-
G
G
-
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
--
M
S
F
L
D
P
S
P
G
G
S
Y
A
------
Y
A
R
R
C
F
G
P
-----
F
L
-
G
Y
Q
T
N
V
L
Y
W
-
L
------
A
C
W
I
-
G
--
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
------
D
P
W
V
----
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
-------------
M
-----
A
---------------------
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
-
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
P
N
A
A
L
R
VSAS
P
F
G
D
A
A
R
M
-
A
--
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
FPPIFARVN
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
-
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
7
HHSearch
59.44
14%
-131
- C3 -
3GIA
3
Y609_METJA
A:
[4-250]
---------------------------------------------------------------------
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
-
S
-
I
F
S
I
F
G
V
G
A
K
I
A
-
G
R
-
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
--
L
G
A
K
I
V
S
N
A
G
P
I
A
------
F
I
H
K
A
I
G
D
-----
N
I
I
T
G
A
L
S
I
L
L
W
-
M
------
S
Y
V
I
-
S
--
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
------
I
N
T
F
N
----
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
P
S
Y
V
------------------
I
P
D
L
----------
A
P
---
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
-
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
I
----
K
A
S
E
N
A
L
A
V
A
--
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
---------
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
G
V
--
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
-
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
3
PsiBlast_PDB
51.06
31%
-96
- C3 -
3OB6
1
ADIC_ECOLI
A:
[19-127]
----------------------------------------------------------------------------------
V
S
G
N
I
M
G
S
-
G
-
V
F
L
L
P
A
-
N
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
G
G
-
S
Y
A
Y
A
R
R
C
FG
P
F
L
G
Y
Q
T
N
V
L
-----
Y
W
-
L
A
C
W
I
G
A
I
A
-
M
------
V
V
I
G
-
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
A
A
W
N
V
S
G
L
G
T
F
G
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
P
N
A
A
L
R
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
----
D
G
L
F
P
P
I
F
A
R
--
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
G
L
V
S
S
V
S
V
I
F
T
L
---------
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
--
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
-
L
D
A
----------------------
2
PsiBlast_PDB
49.35
32%
-91
- C3 -
3L1L
1
ADIC_ECO57
A:
[19-116]
----------------------------------------------------------------------------------
V
S
G
A
I
M
G
S
-
G
-
V
F
L
L
P
A
-
N
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
G
G
-
S
Y
A
Y
A
R
R
C
FG
P
F
L
G
Y
Q
T
N
V
L
-----
Y
W
-
L
A
C
W
I
G
N
I
A
-
M
------
V
V
I
G
V
G
--
Y
L
S
Y
F
F
P
I
L
K
D
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
A
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
P
N
A
A
L
R
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
----
V
N
K
A
G
T
P
V
A
G
--
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
---------
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
--
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
---------------------------
4
PsiBlast_PDB
47.04
31%
-81
- C3 -
3LRB
-
ADIC_ECO57
A:
[19-127]
----------------------------------------------------------------------------------
V
S
G
N
I
M
G
S
-
G
-
V
F
L
L
P
A
-
N
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
G
G
-
S
Y
A
Y
A
R
R
C
FGP
F
L
G
Y
Q
T
N
V
L
-----
Y
W
-
L
A
C
W
I
G
N
I
A
-
M
------
V
V
I
G
-
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
A
A
W
N
V
S
G
L
G
T
F
G
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
P
N
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
----
L
I
I
V
G
I
L
M
T
I
--
F
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
---------
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
--
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
------------------------------------------
5
PsiBlast_PDB
46.95
31%
-75
- C3 -
3LRC
-
ADIC_ECO57
A:
[19-127]
----------------------------------------------------------------------------------
V
S
G
N
I
M
G
S
-
G
-
V
F
L
L
P
A
-
N
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
G
G
-
S
Y
A
Y
A
R
R
CFGP
F
L
G
Y
Q
T
N
V
L
-----
Y
W
-
L
A
C
W
I
G
N
I
A
-
M
------
V
V
I
G
-
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
A
A
W
N
V
S
G
L
G
T
F
G
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
P
N
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
----
L
I
I
V
G
I
L
M
T
I
--
F
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
---------
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
--
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
------------------------------------------
8
HHSearch
36.73
8%
-94
- C3 -
2JLN
-
?
A:
[26-186]
------------------------------------------------------------------------
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
-
F
I
A
A
G
Q
-
M
T
S
S
F
-
Q
V
W
Q
V
I
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
--
A
A
I
R
W
G
--
I
N
F
T
V
------
A
A
R
M
P
F
G
I
-----
R
G
-
S
L
I
P
I
T
L
K
A
-
L
------
L
S
L
F
-
W
--
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
T
G
F
--------
T
N
-
L
P
L
W
I
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
G
E
V
M
S
M
G
G
E
N
P
G
M
P
F
S
T
A
I
M
I
F
V
G
G
W
I
A
V
V
V
S
I
H
D
I
V
K
E
C
K
V
D
P
N
A
S
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
M
V
L
V
G
E
W
N
P
V
I
A
I
T
E
V
V
G
G
V
S
I
P
M
A
I
L
F
----
Q
V
F
V
L
L
A
T
W
S
--
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
V
I
V
S
A
V
V
G
L
L
M
M
P
---------
W
Q
F
A
G
V
L
N
T
F
L
N
L
L
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
R
I
S
L
H
--
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
G
V
N
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
D
-
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
9
HHSearch
34.37
15%
-77
- C3 -
3DH4
1
?
A:
[52-177]
---------------------------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
-
E
Q
F
I
G
M
S
G
-
S
G
Y
S
I
-
G
L
A
I
A
S
Y
E
-
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
--
I
F
I
E
K
G
-
I
Y
T
I
P
E
------
F
V
E
K
R
F
N
K
-----
K
L
-
K
T
I
L
A
V
F
W
I
S
L
------
Y
I
F
V
-
N
--
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
----
I
P
----
L
------
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
M
N
L
P
G
I
A
V
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
D
----
I
A
A
T
N
L
P
S
A
A
--
N
A
D
K
A
Y
P
W
L
T
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
---------
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
--
A
P
M
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
-
K
K
T
T
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
21
Fugue
32.46
17%
232
- C3 -
1JO6
-
KCMB2_HUMAN
A:
[1-45]
----------
M
F
I
W
T
S
G
R
T
S
S
S
Y
R
H
D
E
K
R
N
I
Y
Q
K
I
R
D
H
D
L
L
D
K
R
K
T
V
T
A
L
K
A
G
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
30.21
37%
22
- C1 -
3PJP
-
SPT6_CANGA
A:
[138-183]
--------------------------------------------------------------------------------------------------------------------------------------------
S
L
N
Y
E
N
------
P
G
W
--
F
Y
L
-----
I
F
-
K
L
N
A
E
S
K
L
Y
-
I
------
W
N
V
K
-
L
--
T
H
T
G
F
F
L
V
N
Y
N
Y
P
T
V
I
Q
L
C
N
G
F
K
T
L
L
K
S
S
N
T
R
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
29.31
12%
266
- C3 -
1JEK
2
A:
[1-40]
--------------------------
Q
S
L
A
N
A
T
A
A
Q
Q
E
V
L
E
A
S
Y
A
M
V
Q
H
I
A
K
G
I
R
I
L
E
A
R
V
A
R
V
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
26.58
12%
190
- C3 -
2WW9
-
SC61G_YEAST
B:
[37-69]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
C
K
K
P
D
L
K
E
Y
T
K
I
V
K
A
V
G
-
I
G
---
F
I
A
V
G
I
I
G
Y
A
I
K
L
I
H
I
P
I
----
R
Y
V
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
25.62
21%
138
- C3 -
4I7Z
3
UCRI_MASLA
D:
[9-46]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
P
D
M
G
R
R
Q
F
M
N
L
L
A
F
G
T
V
T
G
V
A
L
G
A
L
Y
P
L
V
K
Y
F
I
P
P
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
25.22
17%
10
- C3 -
2WSW
-
?
A:
[176-228]
-----------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
------
T
L
V
P
L
V
G
E
K
H
V
N
G
L
F
-
G
T
V
V
D
N
F
Y
L
-
V
------
A
L
I
L
-
A
--
M
G
T
S
L
G
L
A
T
P
L
V
T
E
C
I
Q
Y
L
F
G
I
P
H
T
L
Q
L
D
A
I
I
I
S
C
W
I
L
L
N
A
I
C
V
A
F
G
L
Q
K
G
V
K
I
A
S
D
V
R
T
Y
L
S
F
L
M
L
G
W
V
F
I
V
G
G
A
S
F
I
V
N
Y
F
T
D
S
V
G
T
L
L
M
Y
M
P
R
M
L
F
Y
T
D
P
I
G
K
G
G
F
P
Q
A
W
T
V
F
Y
W
A
W
W
V
I
Y
A
I
Q
M
S
I
F
L
A
R
I
S
K
G
R
T
V
R
E
L
C
L
G
M
V
S
G
L
T
A
G
T
W
L
I
W
T
I
L
G
G
N
T
L
Q
L
I
D
Q
N
I
L
N
I
P
Q
L
I
D
Q
Y
G
V
P
R
A
I
I
E
T
W
----
A
A
L
P
L
S
T
A
T
M
--
W
G
F
F
I
L
C
F
I
A
T
V
T
L
I
N
A
C
S
Y
T
L
A
M
S
T
C
R
S
M
K
E
G
A
D
P
P
L
L
V
---------
R
I
G
W
S
V
L
V
G
I
I
G
I
I
L
L
A
L
G
G
L
K
P
I
Q
T
A
I
I
A
G
G
C
P
L
F
F
V
N
I
--
M
V
T
L
S
F
I
K
D
A
K
V
H
W
K
----------------------------------------------
25
Fugue
23.87
22%
156
* C3 *
3W5A
-
SARCO_RABIT
C:
[1-31]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
S
T
R
E
L
C
L
N
F
T
V
V
L
I
T
V
I
L
I
W
L
L
V
R
S
Y
Q
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
23.65
16%
335
- C3 -
1FMH
3
GCN4_YEAST
A:
[1-31]
-------------------------------------
E
V
A
Q
L
E
K
E
V
A
Q
A
E
A
E
N
Y
Q
L
E
Q
E
V
A
Q
L
E
H
E
C
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
22.50
25%
167
- C3 -
3MP7
-
SECE_PYRFU
B:
[19-51]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
T
K
K
P
N
W
A
T
Y
K
R
A
A
K
I
T
G
----
L
G
I
I
L
I
G
L
I
G
M
L
I
R
I
V
G
I
L
I
----
L
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
17.08
29%
380
- C3 -
1TER
1
TERT_APIME
A:
[5-21]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
N
R
I
I
I
P
H
M
C
W
K
K
C
G
K
K
-------------------------------------------
16
Fugue
11.27
45%
230
- C3 -
2LK9
-
BST2_HUMAN
A:
[22-45]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
G
I
G
I
L
V
L
L
I
I
V
I
L
G
V
P
L
I
I
F
T
-----------------------------------------------------------------------------------------------------------------------------