@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S38A4_HUMAN: (2015-12-10 )
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGKKKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDENQAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYDPPNSKHH
Atome Classification :
(20 SA)
---------------------.........10........20-----------...-...---..30-----.........40.----.......50........60........-70........----80........90----.-......-.100.......110.......120.......130-.......140......-----.150........160........----------------170.---......180.......190.......200.......210.......220.......230......------..240.......250-----......-------.260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360......----.370.......380.------...------------------------------------------...390.....---..400.......410-........420.......430..---------.....440..-----..---------...450.......460.......---470.......480....----...490......--------.500......-------------.510.......520.......---------530.......540.....---------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------MD
P
M
E
L
RNVNIEPDDESSSGE-----------SAP-D
S
Y
---
I
GI------GN
S
E
K
A
A
M
S
S
QF----ANEDTES
Q
K
F
L
TNGFLG
K
K
K
L
A
D
Y
ADE-HHPGTTSFGM----SSFNL
S
N
A
I
MGS----
G
-
I
L
G
L
S
Y
-
A
M
AN
T
G
I
I
L
F
I
I
M
L
L
A
V
A
I
L
S
L
Y
S
V
H
L
L
L
K
T
A
KE-G
G
S
L
I
Y
E
K
LGEKAFGW-----PG-KI
G
A
F
V
S
I
T
M
-
Q
N
IGAM
S
S
Y
----------------
L
F
I
I
---KYE
L
P
E
V
I
R
A
F
MGLEENTG
E
W
Y
LNG
N
Y
L
I
I
F
VS
V
G
I
I
L
P
L
S
L
L
K
NLGYLGYTSG
F
S
L
T
-
C
M
V
F
F
V
------
S
V
V
I
Y
K
KFQIPCPLP-----VLDHSV-------GNLSFNNTL
P
M
H
V
V
M
LPNNSESSD
V
N
F
M
M
D
YTHRNPAGLDENQAKGSLHDSG
V
E
YEAHSDDKCEP
K
Y
F
V
FNSRT
A
Y
A
I
P
I
L
V
F
A
F
VCHP
E
V
L
P
I
Y
S
E
L
K
D
R
S
R
R
K
M
Q
T
VS----NI
S
I
T
G
M
L
V
M
Y
L
L
A
A
------
L
F
G
------------------------------------------
Y
L
T
F
YG
E
V
E
D
E
---
L
L
H
A
Y
S
K
V
Y
TL
D
I
P
--
L
L
M
V
R
L
A
V
L
V
A
V
T
L
T
V
P
I
V
L
F
PI---------R
T
S
V
I
T
L
LFP-----KR---------
P
F
S
W
I
R
H
F
L
I
A
A
V
L
I
A
LN
N
V
L
V
I
---
L
V
P
T
I
K
Y
I
F
G
F
IGASS
A
----
T
M
L
I
F
I
L
P
A
V
F
Y
--------
L
K
L
V
K
K
E
TFR-------------
S
P
Q
K
V
G
A
L
I
F
L
V
V
G
I
F
F
M
I
G
S
---------
M
A
L
I
I
I
D
W
IYDPPNSKHH---------------------------------------------------------------------------
27
Fugue
89.20
14%
-129
- C1 -
2YIC
2
KGD_MYCS2
A:
[7-868]
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
RGHLMAD
I
D
P
L
R
L
D
N
T
R
F
R
S
T
L
W
D
L
D
R
E
FQRKK
L
R
D
I
L
S
V
L
R
-
D
A
Y
CRH
V
G
V
E
YTHIL
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
TKH
D
K
P
T
V
A
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
-
K
Y
V
G
Q
K
R
F
S
L
EGAE
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
-
L
D
E
V
V
I
-
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
D
V
K
Y
H
L
G
-
A
T
G
T
Y
I
Q
M
F
G
D
N
D
I
E
V
S
L
T
A
N
P
S
-
H
L
E
A
V
D
P
V
L
E
-
G
L
V
R
A
K
Q
D
L
L
DTGEEGSDNRFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
--
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
GDD
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
FK
K
D
V
V
I
D
M
L
C
Y
R
RRGHN
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
-
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
V
R
E
L
E
K
H
L
A
T
--
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
EGRI
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
QDTQRGTFTQRHA
V
I
V
D
RKTG
E
E
F
T
P
L
Q
L
L
ATNPDGTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
---
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D-
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
ISSGEAKWG
Q
L
S
D
V
V
L
L
L
P
H
G
H
EG
Q
G
---------
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
---
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
DGIQ
R
P
L
I
V
F
T
P
K
S
M
L
RNKAAVSD
I
R
D
F
T
E
S
K
F
R
SVLEEPMYTDGEG
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
NRED
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
PNVKEKFWVQEEPANQGA
W
P
S
F
G
L
T
L
P
E
ILPDHFTG
L
K
R
I
S
R
R
AMSAPSSGS
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
16
HHSearch
84.86
12%
-130
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-379]
----------------------------------------------------------------------------------------------------------------------
A
H
K
V
G
L
I
P
----
V
T
L
M
V
S
G
A
I
M
G
S
----
G
-
V
F
L
L
P
A
-
N
L
A
S
T
G
G
-
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-----
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
-
A
C
W
I
G
N
I
A
M
----------------
V
V
I
G
---
V
G
Y
L
S
Y
F
F
P
I
L
K
------
D
P
W
V
----
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
-
L
A
L
I
P
I
------
V
G
I
A
V
F
G
W
F
W
F
R
G
E
-------
T
Y
M
-------------------------
A
-------------------------------------------------------
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
-
K
R
N
V
P
I
A
T
----
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
------
T
A
I
------------------------------------------
M
G
M
I
P
N
A
A
L
R
V
SAS
P
F
G
D
A
A
R
M
A
L
G
D
T
A
--
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
---------
G
Q
T
A
K
A
A
A
D
D
-----
G
L
FPPIFARVN
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
---
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
--
T
L
V
P
Y
L
Y
T
C
A
A
L
--------
L
L
L
G
H
G
H
F
G
K
-------------
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
---------
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
---------------------------------------------------------------------------
5
PsiBlast_PDB
72.22
25%
-120
- C2 -
2BG9
-
ACHA_TORMA
A:
[199-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
T
Y
H
F
I
M
Q
R
I
P
L
Y
F
V
V
N
V
I
I
P
C
L
L
F
S
F
---------
L
T
-
V
L
V
F
Y
L
P
-----
T
D
-----------
S
G
E
K
M
T
L
S
I
S
V
L
L
S
L
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
----
F
T
M
I
F
V
I
S
S
I
I
V
--------
T
V
V
V
I
N
T
H
H
R
-------------
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
---------
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
---------------------------------------------------------------------------
17
HHSearch
71.01
11%
-105
- C2 -
3GIA
3
Y609_METJA
A:
[3-250]
--------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
----
A
V
S
M
A
V
G
V
M
I
G
A
----
S
-
I
F
S
I
F
G
V
G
A
K
I
A
G
R
-
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
-----
N
I
I
T
G
A
L
S
I
L
L
W
M
-
S
Y
V
I
S
I
A
L
F
----------------
A
K
G
F
---
A
G
Y
F
L
P
L
I
N
A
P
I
------
N
T
F
--
N
I
--
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
-
V
K
L
L
I
L
------
G
L
F
I
F
A
G
L
I
T
I
H
P
---------
S
-
Y
-----------------------------------------
V
I
---------------
P
---------
D
L
A
P
S
A
V
----
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
-
K
K
N
V
P
R
A
I
----
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
------
I
S
A
------------------------------------------
I
G
N
L
P
I
D
E
L
I
K
---
A
S
E
N
A
L
A
V
A
A
K
P
F
L
--
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
---------
I
Y
G
G
A
N
V
A
Y
S
-----
L
A
---------
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
---
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
G
V
----
A
S
I
T
S
A
V
F
M
V
I
Y
--------
L
F
V
I
L
S
H
Y
I
L
-------------
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
---------
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
---------------------------------------------------------------------------
12
PsiBlast_PDB
66.67
25%
-120
- C2 -
4BOR
-
ACHA_TORMA
A:
[223-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
T
Y
H
F
I
M
Q
R
I
P
L
Y
F
V
V
N
V
I
I
P
C
L
L
F
S
F
---------
L
T
-
V
L
V
F
Y
L
P
-----
T
D
-----------
S
G
E
K
M
T
L
S
I
S
V
L
L
S
L
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
----
F
T
M
I
F
V
I
S
S
I
I
V
--------
T
V
V
V
I
N
T
H
H
R
-------------
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
---------
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
---------------------------------------------------------------------------
13
PsiBlast_PDB
66.64
25%
-120
- C2 -
4BOT
-
ACHA_TORMA
A:
[223-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
T
Y
H
F
I
M
Q
R
I
P
L
Y
F
V
V
N
V
I
I
P
C
L
L
F
S
F
---------
L
T
-
V
L
V
F
Y
L
P
-----
T
D
-----------
S
G
E
K
M
T
L
S
I
S
V
L
L
S
L
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
----
F
T
M
I
F
V
I
S
S
I
I
V
--------
T
V
V
V
I
N
T
H
H
R
-------------
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
---------
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
---------------------------------------------------------------------------
9
PsiBlast_PDB
66.64
25%
-120
- C2 -
4BOI
-
ACHA_TORMA
A:
[223-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
T
Y
H
F
I
M
Q
R
I
P
L
Y
F
V
V
N
V
I
I
P
C
L
L
F
S
F
---------
L
T
-
V
L
V
F
Y
L
P
-----
T
D
-----------
S
G
E
K
M
T
L
S
I
S
V
L
L
S
L
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
----
F
T
M
I
F
V
I
S
S
I
I
V
--------
T
V
V
V
I
N
T
H
H
R
-------------
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
---------
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
---------------------------------------------------------------------------
10
PsiBlast_PDB
66.63
25%
-120
- C2 -
4BON
-
ACHA_TORMA
A:
[223-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
T
Y
H
F
I
M
Q
R
I
P
L
Y
F
V
V
N
V
I
I
P
C
L
L
F
S
F
---------
L
T
-
V
L
V
F
Y
L
P
-----
T
D
-----------
S
G
E
K
M
T
L
S
I
S
V
L
L
S
L
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
----
F
T
M
I
F
V
I
S
S
I
I
V
--------
T
V
V
V
I
N
T
H
H
R
-------------
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
---------
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
---------------------------------------------------------------------------
26
Fugue
66.51
14%
195
- C2 -
1UIX
-
ROCK2_BOVIN
A:
[-2-1045]
-----------------------
T
S
D
V
A
N
L
A
N
E
K
E
E
L
N
N
K
L
K
-----------
E
A
Q
-
E
Q
L
-------------
S
R
L
K
D
E
E
I
S
A
A
----
A
I
K
A
Q
F
E
K
Q
L
L
T
E
R
T
L
K
T
Q
A
V
N
K
L
A
E
I
M
N
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.51
25%
-120
- C2 -
4BOO
-
ACHA_TORMA
A:
[223-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
T
Y
H
F
I
M
Q
R
I
P
L
Y
F
V
V
N
V
I
I
P
C
L
L
F
S
F
---------
L
T
-
V
L
V
F
Y
L
P
-----
T
D
-----------
S
G
E
K
M
T
L
S
I
S
V
L
L
S
L
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
----
F
T
M
I
F
V
I
S
S
I
I
V
--------
T
V
V
V
I
N
T
H
H
R
-------------
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
---------
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
---------------------------------------------------------------------------
7
PsiBlast_PDB
64.01
25%
-112
- C2 -
4AQ9
-
ACHA_TORMA
A:
[199-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
T
Y
H
F
I
M
Q
R
I
P
L
Y
F
V
V
N
V
I
I
P
C
L
L
F
S
F
---------
L
T
-
V
L
V
F
Y
L
P
-----
T
D
-----------
S
G
E
K
M
T
L
S
I
S
V
L
L
S
L
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
----
F
T
M
I
F
V
I
S
S
I
I
V
--------
T
V
V
V
I
N
T
H
H
R
-------------
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
---------
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
---------------------------------------------------------------------------
30
Fugue
62.56
10%
159
- C2 -
1X8Y
-
LMNA_HUMAN
A:
[313-386]
-----------------------
L
A
A
K
E
A
K
L
R
D
L
E
D
S
L
A
R
E
R
-----------
D
T
S
-
R
R
L
---
L
A
E
------
K
E
R
E
M
A
E
M
R
A
R
M
----
Q
Q
Q
L
D
E
Y
Q
E
L
L
D
I
K
L
A
L
D
M
E
I
H
A
Y
R
K
L
-
L
E
G
E
E
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.73
25%
-110
- C2 -
4AQ5
-
ACHA_TORMA
A:
[199-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
I
T
Y
H
F
I
M
Q
R
I
P
L
Y
F
V
V
N
V
I
I
P
C
L
L
F
S
F
---------
L
T
-
V
L
V
F
Y
L
P
-----
T
D
-----------
S
G
E
K
M
T
L
S
I
S
V
L
L
S
L
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
----
F
T
M
I
F
V
I
S
S
I
I
V
--------
T
V
V
V
I
N
T
H
H
R
-------------
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
---------
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
---------------------------------------------------------------------------
25
Fugue
60.24
7%
158
- C2 -
1IC2
-
TPM1_CHICK
A:
[1-79]
---------------------
M
D
A
I
K
K
K
M
Q
M
L
K
L
D
K
E
N
A
L
D
R
-----------
A
E
Q
A
E
A
D
---
K
K
A
------
A
E
E
R
S
K
Q
L
E
D
E
L
----
V
A
L
Q
K
K
L
K
G
T
E
D
E
L
D
K
Y
S
E
S
L
K
D
A
Q
E
K
-
L
E
L
A
D
K
K
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
54.19
10%
-89
- C2 -
2JLN
-
?
A:
[26-184]
------------------------------------------------------------------------------------------------------------------------
S
V
G
P
F
S
----
L
A
A
I
W
F
A
M
A
I
Q
V
A
---
I
-
F
I
A
A
G
Q
-
M
T
S
S
F
Q
V
W
Q
V
I
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
-
W
G
-
I
N
F
T
V
A
A
R
M
P
F
G
I
-----
R
G
-
S
L
I
P
I
T
L
K
A
L
-
L
S
L
F
W
F
G
F
Q
----------------
T
W
L
G
---
A
L
A
L
D
E
I
T
R
L
L
T
G
F
--------
T
N
L
P
L
-
W
I
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
-
V
L
L
A
M
G
------
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
-----
G
E
V
M
S
M
-------
G
G
E
N
P
G
M
P
F
S
T
A
I
M
I
F
V
G
G
W
I
A
V
V
V
S
I
H
D
I
V
K
E
C
K
V
D
P
N
A
S
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
M
V
L
V
G
E
W
N
P
V
I
A
I
T
E
V
V
G
G
V
S
I
P
M
A
I
L
F
Q
V
F
V
L
L
A
T
----
W
S
T
N
P
A
A
N
L
L
S
P
A
Y
T
------
L
C
S
------------------------------------------
T
F
P
R
V
F
T
F
K
T
G
---
V
I
V
S
A
V
V
G
L
L
M
M
P
W
--
Q
F
A
G
V
L
N
T
F
L
N
L
L
A
S
A
L
G
P
L
A
G
I
---------
M
I
S
D
Y
F
L
V
R
R
-----
R
R
---------
I
S
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
G
V
N
W
V
A
---
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
D
L
----
M
F
V
T
G
L
I
A
A
L
L
L
--------
H
I
P
A
M
R
W
V
A
K
-------------
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
R
P
I
G
P
------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
53.52
32%
161
- C3 -
2VSM
1
GLYCP_NIPAV
A:
[340-385]
--------------------------------------
D
S
N
Q
-----------
T
A
E
-
N
P
V
---
F
T
V
------
F
K
D
N
E
I
L
Y
R
A
Q
L
----
A
S
E
D
T
N
A
Q
K
T
I
T
N
C
F
L
L
K
N
K
I
W
C
I
S
L
V
-
E
I
Y
D
T
G
D
N
V
I
----
R
P
K
L
F
A
V
K
I
P
E
Q
----
C
-
T
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_CBE
52.91
33%
152
* C3 *
2VWD
2
GLYCP_NIPAV
B:
[346-390]
---------------------------------------
S
N
Q
-----------
T
A
E
-
N
P
V
---
F
T
V
------
F
K
D
N
E
I
L
Y
R
A
Q
L
----
A
S
E
D
T
N
A
Q
K
T
I
T
N
C
F
L
L
K
N
K
I
W
C
I
S
L
V
-
E
I
Y
D
T
G
D
N
V
I
----
R
P
K
L
F
A
V
K
I
P
E
Q
----
C
-
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
51.79
32%
158
- C3 -
2VWD
2
GLYCP_NIPAV
A:
[345-390]
--------------------------------------
D
S
N
Q
-----------
T
A
E
-
N
P
V
---
F
T
V
------
F
K
D
N
E
I
L
Y
R
A
Q
L
----
A
S
E
D
T
N
A
Q
K
T
I
T
N
C
F
L
L
K
N
K
I
W
C
I
S
L
V
-
E
I
Y
D
T
G
D
N
V
I
----
R
P
K
L
F
A
V
K
I
P
E
Q
----
C
-
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
51.21
7%
111
- C2 -
2K5J
-
?
A:
[1-80]
-----------------------------------
M
N
S
L
A
G
I
-----------
D
M
G
-
R
I
L
---
L
D
L
------
S
N
E
V
I
K
Q
L
D
D
L
E
----
V
Q
R
N
L
------
P
R
A
D
L
L
R
E
A
V
D
Q
Y
L
I
N
-
Q
S
Q
T
A
R
T
S
V
P
----
G
I
W
Q
G
C
E
E
D
G
V
E
----
Y
-
Q
R
K
L
R
E
-
E
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
48.57
16%
-82
- C2 -
3DH4
1
?
A:
[52-171]
---------------------------------------------------------------------------------------------------------------------
A
G
K
S
L
P
W
W
A
----
V
G
A
S
L
I
A
A
N
I
S
A
----
E
Q
F
I
G
M
S
G
-
S
G
Y
S
I
G
L
A
I
A
S
Y
E
-
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
-
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
-----
K
L
-
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
----------------
L
Y
L
G
---
G
L
A
L
E
T
I
L
G
----
I
P
---------
L
M
-
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
-
F
L
V
L
G
G
------
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
-----
G
W
F
A
G
V
-------
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
M
N
L
P
G
I
A
V
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
D
I
A
A
T
N
L
P
S
----
A
A
N
A
D
K
A
Y
P
W
L
T
Q
F
L
------
P
V
G
------------------------------------------
V
K
G
V
V
F
A
A
L
A
A
---
A
I
V
S
S
L
A
S
M
L
N
S
T
A
--
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
---------
V
G
R
T
A
A
V
V
A
L
-----
I
I
---------
A
C
L
I
A
P
M
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
---
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
----
K
T
T
S
K
G
A
I
I
G
V
V
--------
A
S
I
P
F
A
L
F
L
K
-------------
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
---------
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
---------------------------------------------------------------------------