@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S38A5_HUMAN: (2015-12-10 )
MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVSLGFMFANWATGQSRMSGH
Atome Classification :
(20 SA)
--.........10........20...---------.....30........40......---..50.........60--.....-...70-........80........90......------..100...-.-...110...-----....120.-......130..-.....140..----------.....150....-..--.160.......170.......180.......190.......200.......210.......220.......230.......240.......250-.......260.......270.......280.......290.......300..--.....310------.......320-------.....----..330.........340.......-----------350.......360.......370--....-----...----..380----.--......390.......400.......--410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MELQDPKMNGALPS
D
A
VG
Y
R
Q
E
R
E---------GFLPSRGPAPGSK
P
V
Q
F
MDFEGK---TSF-G
M
S
V
F
N
L
S
N
A
I
--MG
S
G
I
-
L
G
L
A
Y
-
A
M
A
H
T
G
V
I
F
F
L
A
L
L
L
C
I
A
L
L
S
SY
S
I
H
------
L
L
L
TCA
G
I
-
A
-
G
I
R
A
Y
E
Q
L
G
-----
Q
R
AFGPA
G
-
K
V
V
V
A
T
V
I
C
L
H
-
N
V
G
A
M
S
S
Y
L
F
----------
I
I
KSEL
P
L
V
I
G
T
-
F
L
--
Y
MDPEG
D
W
F
L
KGN
L
L
I
I
I
V
S
V
L
I
I
L
P
L
A
L
M
K
HLGYLGYTSG
L
S
L
T
C
M
L
F
F
L
V
S
V
I
Y
K
K
FQL
G
C
AIGHNETAME
S
E
A
L
VGLPSQGLNSSC
E
A
Q
M
F
-
T
VDSQM
S
Y
T
V
P
I
M
A
F
A
F
VCHPE
V
L
P
I
Y
T
E
LCR
P
S
K
R
R
M
Q
A
V
ANV
S
I
G
A
M
F
C
M
--
Y
G
L
T
A
T
F
G
------
Y
L
T
F
Y
S
S
V
K
A
-------
E
M
L
H
M
----YSQ--KD
P
L
I
L
C
V
R
L
A
V
L
L
A
V
T
L
T
-----------
V
P
V
V
L
F
P
I
R
R
A
L
Q
Q
LLFPGKA----FSW
P
-----
R
H
V
----
A
I
A
L
I
----
L
--
L
V
L
V
N
V
L
V
I
C
V
P
T
I
R
D
I
F
G
V
IGSTSA--
P
S
L
I
F
I
L
PS
I
F
Y
L
R
IVPSE
V
E
P
F
LS
W
P
K
I
Q
A
L
C
F
G
V
L
G
V
L
F
M
A
V
S
L
G
F
M
FANWATGQSRMSGH
29
Fugue
79.69
20%
-122
- C3 -
4QPP
3
ANM6_HUMAN
A:
[48-376]
YY
E
C
Y
S
D
V
S
V
H
E
E
M
I
A
D
R
V
R
T
D
A
Y
R
L
---------
G
I
L
R
N
W
A
A
L
R
G
K
--------------------
T
V
L
D
V
G
-----
A
G
T
G
I
-
L
S
I
F
C
-
A
Q
A
G
A
R
R
V
Y
A
V
E
--------
A
S
A
I
W
Q
------
Q
A
R
E
V
V
R
F
-
N
-
G
L
E
D
R
V
H
V
L
-----
P
---
G
P
------
V
E
T
V
E
L
P
E
-
Q
V
D
A
I
V
S
E
W
M
----------
G
Y
G
----
L
L
H
E
S
-
M
L
S
S
V
L
H
A
R
T
K
W
L
K
E
G
G
L
L
L
P
A
S
A
E
L
F
I
V
P
I
S
D
Q
M
L
E
W
R
L
G
F
---
W
S
Q
V
K
Q
H
Y
G
V
D
M
S
C
L
E
G
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
-----
G
L
S
G
E
D
V
L
A
R
-------------------------------
P
Q
R
F
A
Q
L
E
L
S
R
A
G
L
E
Q
E
L
E
A
G
V
G
G
R
F
R
C
S
C
Y
G
S
A
P
M
H
G
----------------------------------------------
F
A
I
W
F
Q
V
T
F
------------------
P
G
G
E
S
E
K
P
L
V
L
S
T
S
P
----
F
H
P
A
-----
T
H
W
----
K
Q
A
L
L
----
Y
--
L
N
E
P
V
Q
V
----
E
Q
D
T
D
V
S
G
E
I
T
L
L
P
S
--
R
D
N
P
R
R
L
R
V
L
L
R
Y
K
V
G
D
Q
E
---------------------------------
E
K
T
K
D
F
A
M
E
D
-
13
HHSearch
78.95
14%
-147
- C5 -
3L1L
2
ADIC_ECO57
A:
[7-380]
-------------------------------------------------------
A
H
K
---
V
G
L
-
I
P
V
T
L
M
V
S
G
A
I
--
M
G
S
G
V
-
F
L
L
P
A
-
N
L
A
S
T
G
G
-
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
------
V
Y
A
K
M
S
F
L
-
D
P
S
P
G
G
S
Y
A
Y
A
-----
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
-
C
W
I
G
N
I
A
M
V
V
----------
I
G
V
G
Y
L
S
Y
F
F
P
I
-
L
-------
K
D
P
W
----
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
---------------
A
---------------
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
-
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
--
Y
V
L
S
T
T
A
I
------
M
G
M
I
P
N
A
A
L
R
VSASP
F
G
D
A
A
R
M
----
A
L
---
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
-----------
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
----
P
P
I
F
ARVNK
A
G
T
----
P
V
A
G
L
I
I
V
G
I
--
L
M
T
I
F
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
25
Fugue
78.79
16%
-122
* C6 *
4IKW
13
?
A:
[3-494]
---
S
I
D
K
Q
Q
I
A
A
S
V
P
---------
Q
R
---------
G
F
F
---
G
H
P
K
G
L
F
T
L
F
F
T
E
F
W
E
R
---
F
S
Y
Y
G
M
R
A
I
L
V
Y
Y
M
Y
YE
V
S
K
G
G
-
L
G
L
D
E
-
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
RVFG
T
S
R
A
V
F
Y
G
G
L
-
L
-
I
M
A
G
H
I
A
L
A
I
PGG
V
A
A
L
F
V
S
M
A
-
L
I
V
L
G
T
G
L
L
K
P
-
N
V
S
S
I
V
G
D
M
Y
KPGDDR
R
D
A
G
F
S
I
F
Y
M
G
I
N
L
G
A
-
F
L
--
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
---
Y
V
P
N
P
L
T
P
A
E
K
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
--
V
E
T
F
I
-
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
S
---
P
K
T
T
-----
A
E
E
R
S
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
--
F
W
A
I
Q
E
Q
G
ST
I
L
A
N
Y
A
D
K
R
T
Q
L
D
V
-------
A
G
I
H
L
S
PAW
F
Q
S
--
L
N
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
GKRQPT
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
I
V
I
L
V
P
G
H
L
S
GGG
L
V
H
P
-----
I
W
L
----
V
L
S
Y
F
----
I
--
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
P
A
A
F
S
A
--
Q
T
M
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
A
Q
L
V
R
F
Y
T
-
P
E
N
E
T
A
Y
F
G
T
I
G
G
--
A
A
L
V
L
G
L
I
L
L
A
I
A
P
R
I
G
R
L
M
K
G
14
HHSearch
75.91
9%
-149
- C5 -
3GIA
6
Y609_METJA
A:
[3-368]
-----------------------------------------------------
L
K
N
K
K
---
L
S
L
-
W
E
A
V
S
M
A
V
G
V
M
--
I
G
A
S
I
-
F
S
I
F
G
V
G
A
K
I
A
G
R
-
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
------
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
-----
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
-
Y
V
I
S
I
A
L
F
A
K
----------
G
F
A
G
Y
F
L
P
L
I
N
A
-
P
-------
I
N
T
F
----
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
P
S
--
Y
--------------------
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
-
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
--
Y
V
G
V
A
I
S
A
------
I
G
N
L
P
I
D
E
L
I
K
A
SEN--
A
L
A
V
A
----
A
K
P
FL
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
-----------
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
----
P
E
F
F
-----
E
R
K
VWFK
S
T
E
G
L
----
Y
I
T
S
A
L
G
V
L
F
A
L
-
L
F
N
M
E
G
V
A
S
I
T
S
A
V
----
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
28
Fugue
74.32
10%
-138
- C4 -
2IUB
-
CORA_THEMA
A:
[17-361]
-----
R
L
S
A
K
K
G
L
P
P
--------------------
G
T
L
V
Y
T
G
K
Y
R
E
D
F
E
I
E
V
M
N
Y
S
I
E
---
E
F
R
-
E
F
K
T
T
D
V
E
S
--------------------------------
V
L
P
F
R
D
S
S
T
P
------
T
W
I
N
I
T
G
I
-
H
-
R
T
D
V
V
Q
R
V
G
-----
E
F
F
--
G
I
H
-
P
L
V
L
E
D
I
L
N
V
H
-
Q
R
P
K
V
E
F
F
---------------
E
N
Y
V
F
I
V
L
K
-
M
F
--
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
----------------------------
N
C
V
L
M
F
Q
E
K
I
--------------------
G
D
V
F
D
P
V
R
E
R
I
R
Y
N
R
G
-
I
I
R
K
K
-----
R
A
D
Y
L
L
Y
S
L
I
D
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
--------------------------------------------------
E
--
R
P
E
K
E
T
V
Q
R
T
H
Q
L
K
R
N
L
V
E
-----------
L
R
K
T
I
W
P
L
R
E
V
L
S
S
L
Y
R
D
V
P
P
----
L
I
E
K
-----
E
T
V
----
P
Y
F
R
D
----
V
--
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
V
Y
L
--
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
------
G
I
Y
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
K
--
30
Fugue
56.98
30%
216
- C6 -
2K5K
-
?
A:
[1-62]
--
M
R
D
M
T
E
E
T
R
K
D
L
P
P
E
A
L
R
A
L
A
E
A
E
E
R
RRRAKAL
D
L
P
K
E
I
G
G
R
N
G
P
E
P
V
R
F
G
D
W
E
K
K
GIA
I
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.26
22%
-112
- C5 -
4BOR
-
ACHA_TORMA
A:
[233-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
Y
F
V
V
N
V
I
-----------
I
P
C
L
L
F
S
F
L
T
V
L
V
F
Y
L
P
T
D
S
G
----
E
K
M
T
-----
L
S
I
----
S
V
L
L
S
----
L
--
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
--
F
T
M
I
F
V
I
S
S
I
I
V
T
V
V
V
I
N
T
H
H
R
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
H
I
12
PsiBlast_PDB
55.88
22%
-112
- C5 -
4BOT
-
ACHA_TORMA
A:
[233-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
Y
F
V
V
N
V
I
-----------
I
P
C
L
L
F
S
F
L
T
V
L
V
F
Y
L
P
T
D
S
G
----
E
K
M
T
-----
L
S
I
----
S
V
L
L
S
----
L
--
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
--
F
T
M
I
F
V
I
S
S
I
I
V
T
V
V
V
I
N
T
H
H
R
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
H
I
4
PsiBlast_PDB
55.71
22%
-112
- C5 -
2BG9
-
ACHA_TORMA
A:
[209-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
Y
F
V
V
N
V
I
-----------
I
P
C
L
L
F
S
F
L
T
V
L
V
F
Y
L
P
T
D
S
G
----
E
K
M
T
-----
L
S
I
----
S
V
L
L
S
----
L
--
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
--
F
T
M
I
F
V
I
S
S
I
I
V
T
V
V
V
I
N
T
H
H
R
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
H
I
8
PsiBlast_PDB
55.37
22%
-112
- C5 -
4BOI
-
ACHA_TORMA
A:
[233-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
Y
F
V
V
N
V
I
-----------
I
P
C
L
L
F
S
F
L
T
V
L
V
F
Y
L
P
T
D
S
G
----
E
K
M
T
-----
L
S
I
----
S
V
L
L
S
----
L
--
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
--
F
T
M
I
F
V
I
S
S
I
I
V
T
V
V
V
I
N
T
H
H
R
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
H
I
10
PsiBlast_PDB
55.32
22%
-112
- C5 -
4BOO
-
ACHA_TORMA
A:
[233-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
Y
F
V
V
N
V
I
-----------
I
P
C
L
L
F
S
F
L
T
V
L
V
F
Y
L
P
T
D
S
G
----
E
K
M
T
-----
L
S
I
----
S
V
L
L
S
----
L
--
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
--
F
T
M
I
F
V
I
S
S
I
I
V
T
V
V
V
I
N
T
H
H
R
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
H
I
9
PsiBlast_PDB
55.32
22%
-112
- C5 -
4BON
-
ACHA_TORMA
A:
[233-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
Y
F
V
V
N
V
I
-----------
I
P
C
L
L
F
S
F
L
T
V
L
V
F
Y
L
P
T
D
S
G
----
E
K
M
T
-----
L
S
I
----
S
V
L
L
S
----
L
--
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
--
F
T
M
I
F
V
I
S
S
I
I
V
T
V
V
V
I
N
T
H
H
R
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
H
I
5
PsiBlast_PDB
54.28
22%
-110
- C5 -
4AQ5
-
ACHA_TORMA
A:
[209-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
Y
F
V
V
N
V
I
-----------
I
P
C
L
L
F
S
F
L
T
V
L
V
F
Y
L
P
T
D
S
G
----
E
K
M
T
-----
L
S
I
----
S
V
L
L
S
----
L
--
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
--
F
T
M
I
F
V
I
S
S
I
I
V
T
V
V
V
I
N
T
H
H
R
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
H
I
6
PsiBlast_PDB
53.27
22%
-113
- C5 -
4AQ9
-
ACHA_TORMA
A:
[209-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
Y
F
V
V
N
V
I
-----------
I
P
C
L
L
F
S
F
L
T
V
L
V
F
Y
L
P
T
D
S
G
----
E
K
M
T
-----
L
S
I
----
S
V
L
L
S
----
L
--
T
V
F
L
L
V
I
V
E
L
I
P
S
T
S
S
A
V
P
L
I
G
K
Y
M
L
--
F
T
M
I
F
V
I
S
S
I
I
V
T
V
V
V
I
N
T
H
H
R
S
P
S
T
H
S
A
I
E
G
V
K
Y
I
A
E
H
M
K
S
D
E
E
S
S
N
A
A
E
E
W
K
Y
V
A
M
V
I
D
H
I
23
Fugue
52.25
24%
373
- C5 -
4JS0
1
B:
[4-32]
----------------------
S
N
L
V
---------
I
S
D
P
I
P
G
A
K
P
L
P
V
P
P
E
L
A
P
F
V
G
R
---
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
51.47
10%
-107
- C5 -
2JLN
-
?
A:
[23-187]
------------------------------------------------------
A
E
R
S
---
V
G
P
-
F
S
L
A
A
I
W
F
A
M
A
--
I
Q
V
A
I
F
I
A
A
G
Q
-
M
T
S
S
F
Q
V
W
Q
V
I
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
------
F
T
Q
S
A
A
I
R
-
W
-
G
-
I
N
F
T
V
A
A
-----
R
M
P
F
G
I
R
G
-
S
L
I
P
I
T
L
K
A
L
L
-
S
L
F
W
F
G
F
Q
T
W
----------
L
G
A
L
A
L
D
E
I
T
R
L
-
L
T
--
G
F
-----
T
--
N
-
L
P
L
W
I
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
G
E
V
M
S
M
G
G
E
N
P
G
M
P
F
S
T
A
I
M
I
F
V
G
G
W
I
A
-
V
V
V
S
I
H
D
I
V
K
E
C
K
V
D
P
N
A
S
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
--
M
V
L
V
G
E
W
N
------
P
V
I
A
I
T
E
V
V
G
-------
G
V
S
I
P
----
M
A
I
--
L
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
-----------
L
S
P
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
V
----
I
V
S
A
-----
V
V
G
----
L
L
M
M
P
----
W
--
Q
F
A
G
V
L
N
T
F
L
N
L
L
A
S
A
L
G
P
L
A
G
I
M
I
S
--
D
Y
F
L
V
R
R
R
R
I
S
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
G
V
N
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
D
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
15
HHSearch
48.54
13%
-92
- C5 -
3DH4
1
?
A:
[51-177]
-----------------------------------------------------
K
A
G
K
S
---
L
P
W
-
W
A
V
G
A
S
L
I
A
A
N
--
I
S
A
E
Q
F
I
G
M
S
G
-
S
G
Y
S
I
G
L
A
I
A
S
Y
-
E
W
M
S
A
I
T
L
I
I
V
G
K
------
Y
F
L
P
I
F
I
E
-
K
-
G
I
Y
T
I
P
E
F
V
-----
E
K
R
F
N
K
K
L
-
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
----------
L
G
G
L
A
L
E
T
I
L
G
I
---------------
P
-
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
-
M
N
L
P
G
I
A
V
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
--
I
V
P
F
L
V
V
L
------
P
G
I
A
A
Y
V
I
T
S
-------
D
P
Q
L
M
----
A
S
L
--
G
D
I
A
A
T
N
L
P
S
A
A
N
A
D
K
A
Y
P
-----------
W
L
T
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
----
I
V
S
S
-----
L
A
S
----
M
L
N
S
T
----
A
--
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
--
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
K
G
A
I
I
G
V
V
A
S
2
PsiBlast_PDB
47.68
31%
-133
- C5 -
3QE7
1
URAA_ECOLI
A:
[44-114]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
V
L
L
F
N
-
G
I
G
T
L
L
-
Y
L
F
----------
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
--
F
I
S
P
----------------
V
L
L
L
L
P
L
------
G
Y
E
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
L
-
L
P
A
E
G
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
--
M
G
I
V
D
T
T
P
------
I
I
N
A
H
W
F
A
L
P
-------
T
L
Y
T
P
----
R
F
E
--
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
-----------
G
H
L
V
V
T
A
N
I
V
K
K
D
L
L
R
D
P
G
L
H
----
R
S
M
F
-----
A
N
G
----
L
S
T
V
I
----
S
--
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
R
V
Y
S
T
--
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
3
PsiBlast_PDB
47.58
38%
46
- C2 -
3AGR
-
?
A:
[270-311]
------------
A
L
P
S
S
I
R
A
V
N
L
Q
H
E
---------
R
F
L
P
S
R
F
P
S
A
D
V
I
S
V
S
F
M
Q
L
G
V
A
---
S
S
S
-
G
L
F
F
K
E
L
C
S
N
A
--
E
F
R
H
Q
-
G
I
C
Y
N
-
P
C
I
F
R
G
F
R
Q
A
C
S
A
G
D
V
E
I
L
P
D
G
T
I
V
V
------
D
E
D
V
R
K
N
K
-
L
-
K
P
V
A
T
Y
C
S
A
-----
N
N
P
E
I
S
F
K
-
A
M
N
E
I
Q
C
R
V
N
K
-
I
D
P
T
K
S
L
A
E
R
----------
L
R
I
D
D
C
F
Q
I
V
G
T
-
G
D
--
F
D
T
C
Q
A
Q
V
E
E
L
L
V
S
P
R
F
P
L
P
A
N
I
E
A
A
S
S
G
F
E
S
V
G
Q
V
F
K
F
A
S
T
A
S
P
M
V
I
T
G
G
A
M
Y
A
S
I
S
T
M
Q
G
L
G
L
L
P
K
D
F
Q
G
D
L
E
Q
L
I
A
A
S
R
T
Y
C
S
S
P
V
V
N
N
G
D
-
G
L
V
I
Q
L
P
N
A
E
Q
K
L
T
S
M
N
Y
D
L
C
K
T
I
A
L
T
V
S
L
L
Q
H
M
E
A
G
E
H
K
P
S
S
I
S
W
Q
K
T
V
V
G
--
P
D
G
K
P
R
A
D
------
L
G
W
H
V
G
A
I
L
H
-------
R
V
L
F
T
----
E
E
W
--
G
R
T
A
Y
E
T
G
F
T
Y
N
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
47.11
26%
48
- C5 -
1JB0
-
PSAI_THEEB
I:
[1-38]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
M
G
S
Y
A
A
S
F
L
P
W
I
F
I
P
V
V
C
W
-----
L
M
P
T
V
V
M
G
L
L
F
L
Y
I
E
G
E
A
------