@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S38A6_HUMAN: (2015-12-10 )
MEASWGSFNAERGWYVSVQQPEEAEAEELSPLLSNELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFDWINK
Atome Classification :
(20 SA)
--------------.........10......---..20........30........40-...-.....50........60-----------------------.-...----....70.......---------------.80---.........90........100-...---------....110.......120........130.......---.140.......150.......160....-----...170----.......180.......190-.....-..200..--.....210..-----..--------...220.....--..230---....---.....240..-....-----.250.......------260...-...----------------.--------270...---....280.......-290------------------------......-----..300.-----......310.-----......320...-------....330.....---------..340----.......350.......360......-----.370.-..--..------------..380.......390...---------------......400.--......410...---....420....--...430.......-440.......----------450....------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MEASWGSFNAER
G
W
Y
V
S---VQQPEEA
E
A
E
E
L
S
P
L
L
S
N
E
L
H
R
QR-SPG-
V
S
F
G
L
S
V
F
N
L
M
N
A
I
MGS-----------------------
G
-
I
L
G
----
L
A
Y
V
L
ANTG
V
F
G
F
---------------
S
F
----
L
L
L
T
V
A
L
L
A
S
Y
S
V
H
L
L
L
S
M
C
I
Q
-
T
A
V---------TSYED
L
G
L
F
A
FGLPG-
K
L
V
V
A
G
T
I
I
I
-
Q
N
IGAM
S
S
---
Y
L
L
I
I
KTE
L
P
A
A
I
A
E
F
LTGDY
S
R
Y
W
Y
LD-----G
Q
T
L
L
I
----
I
I
C
V
G
I
V
F
P
L
A
L
L
PKIGFLG-Y
T
S
S
L
-
S
F
F
F
M
M
F
--
F
A
L
V
V
I
I
K
KW-----SI--------PC
P
L
T
L
N
Y
V
EK--G
F
Q
-----ISNV---TDDCKP
K
L
F
H
-FSKE-----SAYA
L
P
T
M
A
F
S
------
F
L
CHTS-
I
L
P
----------------
I
--------
Y
C
ELQS---P
S
K
K
R
M
Q
N
V
T
N
T
A
I
-
A
L
-------------------------
S
F
L
I
Y
F
-----
I
S
A
L
F
G
-----
Y
L
T
F
Y
D
K
V
E
S
-----
E
L
L
K
G
Y
S
K
Y
LSH-------
D
V
V
V
M
T
V
K
L
C
I
L
---------
F
A
V
L
L
----
T
V
P
L
IHFPA
R
K
A
V
T
M
M
F
FSNF
P
F
S
W
I
-----
R
H
F
L
I
-
T
L
--
A
L
------------
N
I
I
I
V
L
L
A
I
YVP
D
--
I
R
N
---------------
V
F
G
VVGAST
S
--
T
C
L
I
F
IFP
G
L
F
Y
---
L
KL
S
R
E
D
F
L
S
W
--
K
K
L
G
A
F
V
L
L
I
F
G
I
-
L
VGN
F
S
L
A
L
I
----------
I
F
D
WINK------------
21
Fugue
81.62
20%
-139
- C1 -
4J0D
4
?
A:
[22-491]
--------------
S
M
S
N
R
L
I
F
D
A
D
W
L
V
P
E
Q
---
V
Q
V
A
G
Q
A
I
Q
Y
Y
A
A
R
---
N
I
Q
Y
V
Q
H
-
P
V
A
-
A
I
Q
V
L
N
V
F
V
P
A
A
Y
L
H
G
S
-----------------------
S
-
V
N
G
YQRA
T
A
P
I
L
M
P
N
T
V
G
G
Y
LPGPADDPQRVTWPT
N
A
----
G
T
I
Q
Q
A
L
K
R
G
Y
---
V
V
V
A
A
G
I
R
-
G
R
T
---------
T
V
D
K
S
---------
G
-
Q
R
V
G
Q
A
P
A
F
I
-
V
D
M
K
A
A
I
R
---
Y
V
K
Y
N
Q
G
R
L
P
G
D
A
N
R
I
I
T
N
G
T
S
----
A
G
-----
G
A
T
S
A
L
----
A
G
A
S
G
N
--
S
A
Y
F
E
P
A
L
T
A
L
G
-
A
A
P
A
T
D
D
I
F
A
V
S
A
--
Y
C
P
I
H
N
L
E
H
A
-----
D
M
--------
A
Y
E
W
Q
F
N
G
I
N
D
--
W
H
R
-----
Y
Q
P
V
A
G
T
T
K
N
G
R
P
K
F
E
P
-
V
S
G
Q
L
T
---
V
E
E
Q
A
L
S
L
A
L
K
------
A
Q
F
S
T
Y
-
L
N
Q
----------------
L
KLTASDG
T
H
L
T
L
N
E
---
A
G
M
G
S
F
R
D
V
V
R
Q
L
L
-
I
S
-------------------------
S
A
Q
T
A
F
D
Q
GTD
I
H
K
Y
A
G
-----
F
V
V
T
G
N
Q
V
T
D
-----
L
D
L
S
A
Y
L
K
S
L
T
R
M
K
AVPAF
D
Q
L
D
L
T
S
P
E
N
N
L
---------
F
G
D
A
-----
T
A
K
A
K
H
F
T
A
L
A
Q
T
R
----
S
T
V
T
A
Q
L
A
-----
D
A
E
L
I
-
Q
A
I
N
P
L
------------
S
Y
L
T
T
T
S
S
Q
V
A
K
H
--
W
R
I
---------------
R
H
G
A
A
D
R
D
T
S
------
F
A
I
P
I
I
L
A
---
I
M
L
E
N
H
G
Y
--------
G
I
D
F
A
L
P
W
D
I
P
H
S
G
D
Y
D
L
G
D
L
-----------
F
S
W
I
D
G
L
C
Q---------
18
Fugue
76.40
20%
-150
- C4 -
4WGV
-
?
A:
[5-399]
-------------------------
V
G
Y
---------------------------------------
M
D
P
G
N
W
I
T
S
M
Q
G
G
-----------------------
A
-
Q
Y
G
---------------------------------
Y
----
T
L
L
F
V
I
L
I
S
S
L
A
A
M
L
L
Q
S
M
T
V
R
-
L
G
I
---------
A
T
G
K
D
L
A
Q
M
T
R
H
F
L
S
-
K
P
V
A
I
I
F
W
I
I
-
A
E
L
A
I
I
A
T
---
D
I
A
E
V
---
I
G
S
A
I
A
L
D
L
I
F
G
I
P
---------------
L
I
----
V
G
A
L
I
T
V
F
D
V
F
L
L
L
F
I
M
R
F
G
-
F
R
K
I
E
-
A
I
V
G
T
L
I
--
F
T
V
L
A
I
F
V
F
E
-----
V
F
--------
I
S
S
P
Q
L
T
D
I
L
N
--
G
F
V
-----
P
H
K
-----
E
I
V
T
N
Q
G
I
L
-
Y
I
A
L
-----
G
I
I
G
A
T
I
M
P
H
N
------
L
Y
L
H
S
S
-
I
V
Q
S
R
K
Y
D
R
HDNEEK
A
Q
A
I
K
--------
Y
A
T
I
D
S
---
N
L
Q
L
S
I
A
F
V
V
N
C
L
L
L
T
L
-------------------------
G
A
A
L
F
F
GTK--
T
N
D
L
G
G
-----
F
Y
D
L
Y
H
A
L
K
T
-----
E
P
V
L
G
A
----
T
L
-------
G
G
V
M
S
T
L
F
A
V
A
L
---------
L
A
S
G
Q
----
N
S
T
I
T
G
T
L
A
G
Q
I
V
M
E
G
F
L
R
L
S
I
P
N
W
L
-----
R
R
L
I
T
R
S
L
--
A
V
------------
I
P
V
I
I
C
L
I
I
F
K
G
N
--
S
E
K
---------------
I
E
Q
L
L
V
F
S
Q
V
--
F
L
S
I
A
L
P
F
S
L
I
P
---
L
Q
L
A
T
S
N
------
K
K
L
M
G
P
F
I
N
K
T
W
V
-
N
I
I
S
W
T
L
I
V
I
----------
L
S
G
L
N
V
Y
------------
22
Fugue
68.16
16%
-126
- C3 -
4UI9
-
ANC2_HUMAN
N:
[15-730]
RPGQELLVAWNTVS
T
E
E
L
R
A
A
V
E
V
L
R
G
H
V
L
E
EWF
V
E
V
L
Q
N
D
L
Q
A
N
I
S
P
E
F
W
N
A
I
S
Q
C
E
-
N
S
A
C
L
L
L
L
L
D
A
F
G
L
L
E
S
R
L
D
P
YLRSLELLEKWTRLGLLMGTGAQ
G
-
L
R
E
----
E
V
H
T
M
L
R
G
V
L
F
F
S
---------------
T
P
----
R
T
F
Q
E
M
I
Q
R
L
Y
G
C
F
L
R
V
Y
M
Q
S
K
-
R
K
G
DPELEGELD
S
R
Y
A
R
R
R
Y
Y
R
L
L
Q
S
P
-
L
W
C
R
Q
A
L
E
Q
F
-
H
Q
L
S
Q
V
L
H
---
R
L
S
L
L
E
R
V
S
A
E
A
V
T
T
T
L
H
Q
V
T
R
E
R
M
E
D
R
CRGEY
E
R
S
F
L
R
----
E
F
H
K
W
I
E
R
V
V
G
W
L
G
K
V
F
T
L
R
R
W
R
C
H
V
-
Q
R
F
F
Y
R
I
--
Y
A
S
L
R
I
E
E
L
F
-----
S
I
VRDFPDSR
P
A
I
E
D
L
K
Y
C
L
E
--
R
T
D
QRQQL
L
V
S
L
---
K
A
A
L
E
T
R
L
L
H
-
P
G
V
N
TCDII
T
L
Y
I
S
A
I
K
A
L
R
VIDPSM
V
I
L
E
V
A
-
C
E
P
----------------
I
--------
R
R
Y
L
R
T
RED
T
V
R
Q
I
V
A
G
L
T
D
L
A
V
-
E
L
SKEPEDWVPDPVDADPGKSSSKRRS
S
D
I
I
S
L
-----
L
V
S
I
Y
G
SKDLF
I
N
E
Y
R
S
L
L
A
D
-----
R
L
L
H
Q
F
S
--
F
S
P
-------
E
R
E
I
R
N
V
E
L
L
K
L
RFGEAPMHF
C
E
V
M
L
KDMA
D
S
R
R
I
N
A
N
I
R
E
E
D
E
K
R
P
A
E
E
Q
P
P
F
G
V
-----
Y
A
V
I
L
-
S
S
--
E
F
WPPFKDEKLEVP
E
D
I
R
A
A
L
E
A
Y
C
K
K
--
Y
E
Q
LKAMRTLSWKHTLGL
V
T
M
D
V
E
L
A
D
R
--
T
L
S
V
A
V
T
P
V
Q
A
V
---
I
L
L
Y
F
Q
D
Q
A
S
W
TL
E
E
L
S
K
A
V
K
M
P
V
A
L
-
L
R
R
R
M
S
V
W
L
Q
QGVLREEPPG
T
F
S
V
I
E
E
ERPQDRDNMVLI
7
HHSearch
66.87
13%
-143
- C4 -
3L1L
2
ADIC_ECO57
A:
[7-380]
-----------------------------------------------------------
A
H
K
-
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
-----------------------
G
-
V
F
L
----
L
P
A
N
L
A
S
T
G
G
-
I
A
---------------
I
Y
----
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
---------
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
-
A
C
W
I
G
N
I
A
---
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
D
-----
P
W
---------
V
L
T
I
T
----
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
-
R
V
Q
A
V
-
A
T
V
L
A
L
I
--
P
I
V
G
I
A
V
F
G
W
-----
F
W
--------
F
R
G
E
T
Y
M
----------------------
A
------------
A
-----
I
Q
S
T
L
N
V
T
L
W
S
------
F
I
G
V
E
S
-
A
S
V
----------------
A
--------
A
G
V
V
K
N
---
P
K
-
R
N
V
P
I
A
T
I
G
G
V
-
L
I
-------------------------
A
A
V
C
Y
V
-----
L
S
T
T
A
I
-----
M
G
M
I
P
N
A
A
L
R
VSAS-
P
F
G
D
A
A
R
M
A
-
L
G
-------
D
T
A
G
A
I
V
S
F
C
A
A
---------
A
G
C
L
G
----
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
ARVNK
A
G
T
P
V
-
A
G
--
L
I
I
V
G
I
--------
L
M
T
I
F
Q
L
S
S
I
S
P
N
--
A
T
K
---------------
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
---
L
L
L
G
H
G
H
F
G
K
A
--
R
P
A
Y
L
A
V
T
T
I
A
F
L
-
Y
C
I
W
A
V
V
G
S
G
----------
A
K
E
V
M
W
S
------------
25
Fugue
55.24
23%
-60
- C3 -
4WWX
-
RAG2_MOUSE
X:
[1-349]
--------------------------------------------
S
L
Q
M
V
T
V
G
H
N
I
A
L
I
-
Q
P
G
---
F
S
L
M
N
F
D
G
Q
V
F
F
F
G
Q
-----------------------
K
---
G
----
W
P
K
R
S
C
P
T
G
V
F
H
F
---------------
D
I
KQNH
L
K
L
K
P
A
I
F
S
K
D
S
C
Y
L
--
P
P
L
R
Y
-
P
A
T
---------
C
S
Y
K
H
Q
Y
I
I
H
G
G
K
T
P
-
N
N
E
L
S
D
K
I
Y
I
-
M
S
V
A
C
K
N
N
KKV
T
F
R
C
T
E
K
D
L
V
G
D
V
P
E
P
R
Y
G
H
S
I
D
V
V
Y
S
R
-----
G
K
S
----------
M
G
V
L
F
--------
G
G
R
S
-
Y
M
P
S
--------------------------------------------
T
Q
R
--
T
T
E
-----
K
W
N
S
---
V
A
D
C
L
P
H
V
F
L
-
I
D
----------------
F
E
------
F
G
C
A
T
S
Y
I
L
P
---------------------------
E
L
Q
D
---
G
L
S
F
H
V
S
I
A
R
N
D
--------------------------------
T
V
Y
I
-----
L
G
G
H
-------------------------
S
L
A
S
N
I
R
P
A
-------
N
L
Y
R
I
R
V
D
L
----------------------------
P
P
A
V
N
C
T
V
L
P
I
S
------
V
-----
S
S
A
I
L
-
T
Q
--
T
N
------------
N
D
E
F
V
I
V
G
G
Y
Q
L
E
NQ
K
R
M
---------------
V
C
S
L
V
S
L
G
D
N
--
T
I
E
I
S
E
M
E
T
P
D
W
TSD
I
K
H
S
K
I
W
F
G
S
N
--
M
G
N
G
T
I
F
L
G
I
P
G
A
-
M
S
E
A
F
Y
F
Y
T
L
----------
R
C
-----------------
8
HHSearch
51.11
10%
-140
- C4 -
3GIA
5
Y609_METJA
A:
[3-307]
--------------------------------------------------------
L
K
-
N
K
K
-
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
-----------------------
S
-
I
F
S
----
I
F
G
V
G
A
K
I
A
G
R
N
L
---------------
P
E
----
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
---------
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
-
S
Y
V
I
S
I
A
L
---
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
-----
N
T
F
---------
N
I
A
I
T
----
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
-
R
A
E
F
F
-
I
V
L
V
K
L
L
--
I
L
G
L
F
I
F
A
G
L
-----
I
T
--------
I
H
P
S
Y
--------------------------
V
I
P
D
L
A
P
S
A
V
S
G
-----
M
I
F
A
S
A
I
F
F
L
S
------
Y
M
G
F
G
V
-
I
T
N
----------------
A
--------
S
E
H
I
E
N
---
P
K
-
K
N
V
P
R
A
I
F
I
S
I
-
L
I
-------------------------
V
M
F
V
Y
V
-----
G
V
A
I
S
A
-----
I
G
N
L
P
I
D
E
L
I
K
A
SEN
A
L
A
V
A
A
K
P
F
L
G
--------
N
L
G
F
L
L
I
S
I
G
A
L
---------
F
S
I
S
S
----
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
-----
E
R
K
V
W
-
F
K
--
S
T
------------
E
G
L
Y
I
T
S
A
L
G
V
L
F
--
A
L
L
---------------
F
N
M
E
G
V
A
S
I
T
--
S
A
V
F
M
V
I
Y
L
F
V
I
---
L
S
H
Y
I
L
I
D
E
V
G
--
G
R
K
E
I
V
I
F
S
F
I
V
V
-
L
G
V
F
L
L
L
L
Y
Y
----------
Q
W
I
T
N
R
F
------------
10
HHSearch
32.44
10%
-113
- C4 -
2JLN
-
?
A:
[22-186]
--------------------------------------------------------
Y
A
-
E
R
S
-
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
-----------------------
A
I
F
I
A
----
A
G
Q
M
T
S
S
F
Q
V
W
Q
V
---------------
I
V
----
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
-
W
G
----------
I
N
F
T
V
A
A
R
M
P
F
G
I
R
G
-
S
L
I
P
I
T
L
K
A
L
-
L
S
L
F
W
F
G
F
---
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
T
G
F
T
-------
N
------
L
P
L
W
I
----
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
-
W
M
N
V
F
-
A
S
P
V
L
L
A
--
M
G
V
Y
M
V
Y
L
M
L
-----
D
G
--------
A
D
V
S
L
G
E
V
M
S
M
--
G
G
E
-----
N
P
G
M
---
P
F
S
T
A
I
M
I
F
V
-
G
G
W
I
-----
A
V
V
V
S
I
H
D
I
V
K
------
E
C
K
V
D
P
-
N
A
S
----------------
R
--------
E
G
Q
T
K
A
---
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
-
A
S
-------------------------
I
I
F
G
F
I
-----
G
A
A
S
M
V
-----
L
V
G
E
W
N
P
V
I
A
-----
I
T
E
V
V
G
G
V
S
I
P
M
-------
A
I
L
F
Q
V
F
V
L
L
A
T
---------
W
S
T
N
P
----
A
A
N
L
L
S
P
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
V
I
-----
V
S
A
V
V
-
G
L
--
L
M
------------
M
P
W
Q
F
A
G
V
L
N
T
F
L
--
N
L
L
---------------
A
S
A
L
G
P
L
A
G
I
--
M
I
S
D
Y
F
L
V
R
R
R
R
---
I
S
L
H
D
L
Y
R
T
K
G
--
I
Y
T
Y
W
R
G
V
N
W
V
A
L
-
A
V
Y
A
V
A
L
A
V
S
----------
F
L
T
P
D
L
M
------------
26
Fugue
31.37
17%
-4
* C3 *
1EZV
-
H:
[1-74]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
D
Q
L
-
E
D
L
R
E
H
F
K
N
T
E
E
G
K
A
L
V
H
H
-----
Y
E
--------
E
C
A
E
R
V
K
I
Q
Q
Q
QP
G
Y
A
-----
D
L
E
H
---
K
E
D
C
V
E
E
F
F
H
-
L
Q
H
Y
-----
L
D
T
A
T
A
P
R
L
F
D
------
K
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
31.24
29%
31
- C2 -
1XPI
2
RLUC_ECOLI
A:
[89-143]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
V
R
G
Q
W
QSHVK
S
V
--------
Q
A
P
L
L
K
N
I
L
Q
S
--
G
E
R
-----
I
V
R
V
---
S
Q
E
G
K
P
S
E
T
R
-
F
K
V
E
-----
E
R
Y
A
F
A
T
L
V
R
C
------
S
P
V
T
G
R
-
T
H
Q
----------------
I
--------
R
V
H
T
Q
Y
---
A
G
H
P
I
A
F
D
D
R
Y
G
D
R
-
E
F
-------------------------
D
R
Q
L
T
E
-----
A
G
T
G
L
N
-----
R
L
F
L
H
A
A
A
L
K
-----
F
T
H
P
G
T
G
E
V
M
R
I
-------
E
A
P
M
D
E
G
L
K
R
C
L
---------
Q
K
L
R
N
----
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
28.75
29%
33
- C2 -
1V9K
-
RLUC_ECOLI
A:
[86-140]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
V
R
G
Q
W
QSHVK
S
V
--------
Q
A
P
L
L
K
N
I
L
Q
S
--
G
E
R
-----
I
V
R
V
---
S
Q
E
G
K
P
S
E
T
R
-
F
K
V
E
-----
E
R
Y
A
F
A
T
L
V
R
C
------
S
P
V
T
G
R
-
T
H
Q
----------------
I
--------
R
V
H
T
Q
Y
---
A
G
H
P
I
A
F
D
D
R
Y
G
D
R
-
E
F
-------------------------
D
R
Q
L
T
E
-----
A
G
T
G
L
N
-----
R
L
F
L
H
A
A
A
L
K
-----
F
T
H
P
G
T
G
E
V
M
R
I
-------
E
A
P
M
D
E
G
L
K
R
C
L
---------
Q
K
M
R
N
----
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
27.35
24%
347
- C4 -
2IBF
-
IPAA_SHIFL
B:
[1-25]
-----------------------------------
N
H
A
I
Y
E
K
A
K
E
V
S
S
A
L
S
K
V
L
S
K
I
D
-
D
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
27.15
30%
-10
- C2 -
3WO1
2
BACD_BACSU
A:
[222-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
F
I
A
E
E
F
L
Q
G
E
Y
G
D
W
Y
Q
T
E
-----
G
Y
S
D
Y
I
S
I
E
G
I
M
A
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
I
G
-
F
T
E
T
S
-
H
I
T
P
S
I
L
--
D
E
E
A
K
K
K
I
V
E
-----
A
A
--------
K
K
A
N
E
G
L
G
L
Q
N
--
C
A
T
-----
H
T
E
I
---
K
L
M
K
N
R
E
P
G
L
-
I
E
S
A
-----
A
R
F
A
G
A
N
M
I
P
N
------
I
K
K
V
F
G
-
L
D
M
----------------
A
--------
Q
L
L
L
D
V
---
L
C
F
G
K
D
A
D
L
P
D
G
L
L
-
D
Q
-------------------------
E
P
Y
Y
V
A
-----
D
C
H
L
Y
P
-----
Q
H
F
K
Q
N
G
Q
I
P
-----
E
T
A
E
D
L
V
I
E
A
I
D
-------
I
P
D
G
L
L
K
G
D
T
E
I
---------
V
S
F
S
A
----
A
A
P
G
T
S
V
D
L
T
L
F
E
A
F
N
S
I
A
A
F
E
L
K
G
S
-----
N
S
Q
D
V
-
A
E
--
S
I
------------
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
-----------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
26.28
30%
-12
- C2 -
3WNZ
1
BACD_BACSU
A:
[222-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
F
I
A
E
E
F
L
Q
G
E
Y
G
D
W
Y
Q
T
E
-----
G
Y
S
D
Y
I
S
I
E
G
I
M
A
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
I
G
-
F
T
E
T
S
-
H
I
T
P
S
I
L
--
D
E
E
A
K
K
K
I
V
E
-----
A
A
--------
K
K
A
N
E
G
L
G
L
Q
N
--
C
A
T
-----
H
T
E
I
---
K
L
M
K
N
R
E
P
G
L
-
I
E
S
A
-----
A
R
F
A
G
W
N
M
I
P
N
------
I
K
K
V
F
G
-
L
D
M
----------------
A
--------
Q
L
L
L
D
V
---
L
C
F
G
K
D
A
D
L
P
D
G
L
L
-
D
Q
-------------------------
E
P
Y
Y
V
A
-----
D
C
H
L
Y
P
-----
Q
H
F
K
Q
N
G
Q
I
P
-----
E
T
A
E
D
L
V
I
E
A
I
D
-------
I
P
D
G
L
L
K
G
D
T
E
I
---------
V
S
F
S
A
----
A
A
P
G
T
S
V
D
L
T
L
F
E
A
F
N
S
I
A
A
F
E
L
K
G
S
-----
N
S
Q
D
V
-
A
E
--
S
I
------------
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
-----------------------------------------------------------------------------------------------------------------
9
HHSearch
26.03
12%
-86
- C4 -
3DH4
1
?
A:
[53-176]
-----------------------------------------------------------
G
K
S
-
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
-----------------------
E
Q
F
I
G
----
M
S
G
S
G
Y
S
I
G
L
A
I
A
---------------
S
Y
-----
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
-
K
G
I
---------
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
-
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
---
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
------------
P
------
L
M
Y
S
I
----
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
-
W
T
D
V
I
-
Q
V
F
F
L
V
L
--
G
G
F
M
T
T
Y
M
A
V
-----
S
F
--------
I
G
G
T
D
G
W
F
A
G
V
--
S
K
M
-----
V
D
A
A
---
P
G
H
F
E
M
I
L
D
Q
-
S
N
P
Q
-----
Y
M
N
L
P
G
I
A
V
L
I
------
G
G
L
W
V
A
-
N
L
Y
----------------
Y
--------
W
G
F
N
Q
Y
---
I
I
Q
R
T
L
A
A
K
S
V
S
E
A
-
Q
K
-------------------------
G
I
V
F
A
A
-----
F
L
K
L
I
V
-----
P
F
L
V
V
L
P
G
I
A
-----
A
Y
V
I
T
S
D
P
Q
L
M
A
-------
S
L
G
D
I
A
A
T
N
L
P
S
---------
A
A
N
A
D
----
K
A
Y
P
W
L
T
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
-----
V
S
S
L
A
-
S
M
--
L
N
------------
S
T
A
T
I
F
T
M
D
I
Y
K
E
--
Y
I
S
---------------
P
D
S
G
D
H
K
L
V
N
--
V
G
R
T
A
A
V
V
A
L
I
I
---
A
C
L
I
A
P
M
L
G
G
I
--
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
-
V
S
P
G
I
L
A
V
F
L
----------
L
G
L
F
W
K
K
------------
17
Fugue
25.98
30%
408
- C4 -
2XZE
-
CHMP3_HUMAN
Q:
[18-40]
------------------------------------
S
E
D
E
E
E
E
E
E
A
L
E
A
M
Q
S
R
L
A
T
L
R
-
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
25.57
30%
-11
- C2 -
3VMM
2
BACD_BACSU
A:
[222-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
F
I
A
E
E
F
L
Q
G
E
Y
G
D
W
Y
Q
T
E
-----
G
Y
S
D
Y
I
S
I
E
G
I
M
A
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
I
G
-
F
T
E
T
S
-
H
I
T
P
S
I
L
--
D
E
E
A
K
K
K
I
V
E
-----
A
A
--------
K
K
A
N
E
G
L
G
L
Q
N
--
C
A
T
-----
H
T
E
I
---
K
L
M
K
N
R
E
P
G
L
-
I
E
S
A
-----
A
R
F
A
G
W
N
M
I
P
N
------
I
K
K
V
F
G
-
L
D
M
----------------
A
--------
Q
L
L
L
D
V
---
L
C
F
G
K
D
A
D
L
P
D
G
L
L
-
D
Q
-------------------------
E
P
Y
Y
V
A
-----
D
C
H
L
Y
P
-----
Q
H
F
K
Q
N
G
Q
I
P
-----
E
T
A
E
D
L
V
I
E
A
I
D
-------
I
P
D
G
L
L
K
G
D
T
E
I
---------
V
S
F
S
A
----
A
A
P
G
T
S
V
D
L
T
L
F
E
A
F
N
S
I
A
A
F
E
L
K
G
S
-----
N
S
Q
D
V
-
A
E
--
S
I
------------
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
--
V
L
P
---------------
V
--------------------------------------------------------------------------------------------
2
PsiBlast_PDB
25.51
30%
-8
* C2 *
3WO0
2
BACD_BACSU
A:
[222-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
F
I
A
E
E
F
L
Q
G
E
Y
G
D
W
Y
Q
T
E
-----
G
Y
S
D
Y
I
S
I
E
G
I
M
A
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
I
G
-
F
T
E
T
S
-
H
I
T
P
S
I
L
--
D
E
E
A
K
K
K
I
V
E
-----
A
A
--------
K
K
A
N
E
G
L
G
L
Q
N
--
C
A
T
-----
H
T
E
I
---
K
L
M
K
N
R
E
P
G
L
-
I
E
S
A
-----
A
R
F
A
G
W
N
M
I
P
N
------
I
K
K
V
F
G
-
L
D
M
----------------
A
--------
Q
L
L
L
D
V
---
L
C
F
G
K
D
A
D
L
P
D
G
L
L
-
D
Q
-------------------------
E
P
Y
Y
V
A
-----
D
C
H
L
Y
P
-----
Q
H
F
K
Q
N
G
Q
I
P
-----
E
T
A
E
D
L
V
I
E
A
I
D
-------
I
P
D
G
L
L
K
G
D
T
E
I
---------
V
S
F
S
A
----
A
A
P
G
T
S
V
D
L
T
L
F
E
A
F
N
S
I
A
A
F
E
L
K
G
S
-----
N
S
Q
D
V
-
A
E
--
S
I
------------
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
-----------------------------------------------------------------------------------------------------------------
24
Fugue
24.79
28%
380
- C4 -
1YYB
-
PDCD5_HUMAN
A:
[1-26]
-------------------------------------
S
A
D
E
E
L
E
A
L
R
R
Q
R
L
A
E
L
Q
A
K
H
G
D
P
G
-
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
24.35
13%
411
* C4 *
2VOG
-
B:
[4-25]
-------------------------------------
R
A
E
V
Q
I
A
R
K
L
Q
C
I
A
D
Q
F
H
R
L
H
-
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
19.98
16%
-86
- C4 -
2WSW
-
?
A:
[88-112]
-----------------------------------------------------------
K
P
E
-
F
S
T
A
S
W
I
F
M
M
F
A
S
C
T
S
A
-----------------------
A
-
V
L
F
----
W
G
S
I
E
I
Y
Y
Y
I
S
S
P
---------------
P
F
----
G
M
E
G
Y
S
A
P
A
K
E
I
G
L
A
Y
S
L
F
H
W
G
-
P
L
P
---------
W
A
T
Y
S
F
L
S
V
A
F
A
Y
F
F
-
F
V
R
K
M
E
V
I
R
P
-
S
S
T
L
V
P
L
V
---
G
E
K
H
V
N
G
L
F
G
T
V
V
D
N
F
Y
L
V
A
L
I
L
A
M
G
T
S
-----
L
G
L
A
T
P
----
L
V
T
E
C
I
Q
Y
L
F
G
I
P
H
T
L
Q
L
D
A
-
I
I
I
S
C
-
W
I
L
L
N
A
I
--
C
V
A
F
G
L
Q
K
G
V
-----
K
I
--------
A
S
D
V
R
T
Y
L
S
F
L
--
M
L
G
-----
W
V
F
I
---
V
G
G
A
S
F
I
V
N
Y
-
F
T
D
S
-----
V
G
T
L
L
M
Y
M
P
R
M
------
L
F
Y
T
D
P
-
I
G
K
----------------
G
--------
G
F
P
Q
A
W
---
T
V
F
Y
W
A
W
W
V
I
Y
A
I
Q
-
M
S
-------------------------
I
F
L
A
R
I
-----
S
K
G
R
T
V
-----
R
E
L
C
L
G
M
V
S
G
-----
L
T
A
G
T
W
L
I
W
T
I
L
-------
G
G
N
T
L
Q
L
I
D
Q
N
I
---------
L
N
I
P
Q
----
L
I
D
Q
Y
G
V
P
R
A
I
I
E
T
W
A
A
L
P
L
S
T
A
T
M
W
-----
G
F
F
I
L
-
C
F
--
I
A
------------
T
V
T
L
I
N
A
C
S
Y
T
L
A
--
M
S
T
---------------
C
R
S
M
K
E
G
A
D
P
--
P
L
L
V
R
I
G
W
S
V
L
V
---
G
I
I
G
I
I
L
L
A
L
G
--
G
L
K
P
I
Q
T
A
I
I
A
G
G
-
C
P
L
F
F
V
N
I
M
V
----------
T
L
S
F
I
K
D
------------