@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S38A8_HUMAN: (2015-12-10 )
MEGQTPGSRGLPEKPHPATAAATLSSMGAVFILMKSALGAGLLNFPWAFSKAGGVVPAFLVELVSLVFLISGLVILGYAAAVSGQATYQGVVRGLCGPAIGKLCEACFLLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPAPQPWYADQRFTLPLLSVLVILPLSAPREIAFQKYTSILGTLAACYLALVITVQYYLWPQGLVRESHPSLSPASWTSVFSVFPTICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACCLIYSLTGVYGFLTFGTEVSADVLMSYPGNDMVIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWRRSCLGGWGPSALADPSGLWVRMPLTILWVTVTLAMALFMPDLSEIVSIIGGISSFFIFIFPGLCLICAMGVEPIGPRVKCCLEVWGVVSVLVGTFIFGQSTAAAVWEMF
Atome Classification :
(19 SA)
-----------------------.........10.------.......20..-----......30........-----40-........-50........60....--....70..--..-----....80.---.......90...--....------------.-100........110.---.---...-----..-------120.......--------130------.......140.......150...-....160----------.......---170-.......----.---180..---.....---------190......-------.200..----.....210-----......--..220.......230.......240--....---...----..250..-----------..--...260----------------.......270..-.......280.-----...----.-------..--.290.........300---------------------.--....-----..--..310....----...320.......330----........340......-.350---...----.....360.--......370..--------.....380-........---.390----.........400.......410.--......-----420-.......430...----------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------MEGQTPGSRGLP------EKPHP
A
T
A
A
A
T
-----
L
S
S
M
G
A
V
F
I
L
M
K
S
A
LG-----AG-LLNFPWAF-SKAGG
V
V
P
A
F
L
V
E
L
V
S
--
L
V
F
L
I
S
G
L
--
V
I
-----
L
G
Y
A
A
AV---SG
Q
A
T
Y
Q
G
V
V
R
G
--
L
C
G
P
------------
A
-
I
-
G
K
L
C
E
A
C
F
L
L
N
L
L
---
M
---
I
S
V
-----
A
F
-------
L
R
V
I
G
D
Q
L
E
K
--------
L
C
D
------
S
L
LSGTPPAPQPWYADQRF
T
L
P
L
-
L
S
V
L
V
IL----------PLSA
P
R
E
---
I
A
--
F
Q
K
Y
T
S
I
----
L
---
G
T
L
A
A
---
C
Y
L
A
L
---------
V
I
T
V
Q
YYLW-------
P
Q
G
L
VR----ESHPSLS------P
A
S
W
T
S
--
V
F
S
V
F
P
T
I
C
FG
F
Q
C
H
E
A
A
V
S
I
Y
C
----
S
M
R
K
---RS
L
----
S
H
W
A
L
V
S
-----------
V
L
--
S
L
L
A
C
C
----------------
L
I
Y
S
L
T
G
V
--
Y
G
-
F
L
TFGTEV-S
A
-----
D
V
L----M-------SY--PG--N
D
M
V
I
I
V
A
R
V
-----------------------
L
--
F
A
V
S
-----
I
V
--
T
V
Y
P
I
V
L
F
L
----
G
R
S
V
M
Q
D
F
W
R
R
SCLG-----GWGPSALADPS
G
L
W
V
RM-
P
L
T
----
I
L
W
----
V
T
V
T
L
A
M
A
L
--FMP
D
L
S
E
I
V
S
I
--------
I
G
G
I
S
S
---
F
F
I
F
I
FP
G
---
L
C
------
L
I
C
AMGVEPI
G
P
R
V
K
C
C
L
E
V
W
G
V
--
V
S
V
L
V
G
-----
T
F
I-FGQ
S
T
A
A
A
V
WEMF----------------------------------------------------------------------------------------------
22
Fugue
79.59
14%
-122
- C4 -
4LL8
-
A:
[99-536]
------------------ERA
A
A
Q
S
S
L
I
Q
S
H
M
Q
S
L
------
A
A
N
K
P
S
R
L
S
D
E
-----
V
K
S
M
K
Q
E
L
A
F
I
E
N
V
I
A
Q----
A
N
-
K
P
K
L
V
N
V
I
-
R
R
E
S
G
--
N
P
D
L
L
E
L
L
M
--
D
L
N
S
Y
T
L
E
--
V
T
-----
E
G
Y
L
K
K
V
---
N
V
T
E
V
N
G
D
N
V
L
G
--
P
I
-
H
------------
V
-
I
-
T
T
V
V
S
S
L
V
R
N
G
L
L
---
I
---
Q
S
S
-----
K
F
-------
I
S
K
V
L
L
T
V
E
S
--------
I
V
M
------
S
L
P
K
D
E
T
M
L
G
G
I
F
W
L
S
N
L
S
R
L
P
A
-
F
A
A
N
Q
K
T
----------
L
Y
E
A
N
G
G
---
D
E
--
K
D
K
L
T
L
I
----
Y
---
L
N
D
L
E
---
N
E
T
L
K
---------
V
F
D
K
I
Y
S
T
W
-------
L
V
K
F
M
K
----
H
A
S
A
H
I
E
------
I
F
D
M
V
L
--
N
E
K
L
F
K
N
-----
S
G
D
E
K
F
A
K
L
F
T
----
F
L
N
E
F
D
-
A
V
L
----
S
K
F
Q
V
V
D
-----------
S
M
--
H
T
K
I
F
N
----------------
D
T
L
K
Y
L
N
V
--
M
L
-
F
N
D
L
I
T
K
S
-
P
A
-------
L
----
N
-------
W
K
--
Y
G
--
Y
E
V
D
R
N
I
E
R
L
-----------------------
V
S
W
F
E
P
R
-----
I
E
--
D
V
R
P
N
L
I
Q
I
----
I
Q
A
V
K
I
L
Q
L
K
I
S
----------
N
L
N
E
F
K
L
L
F
D
F
W
Y
A
L
N
P
A
Q
----
I
Q
A
----
I
L
L
K
Y
K
P
A
N
KG
E
A
G
V
P
N
E
I
L
N
Y
--------
L
A
N
V
I
K
---
R
E
N
L
S
L
P
G
K
--
M
E
------
I
M
L
S
A
Q
F
D
S
A
K
N
H
L
R
-----
Y
D
T
--
S
A
I
T
Q
N
-----
S
N
T
-
E
G
L
A
T
V
S
K
I
I
K
L
-----------------------------------------------------------------------------------------------
21
Fugue
77.35
16%
-163
- C2 -
4EPQ
1
?
A:
[34-472]
----------D
Y
Q
F
P
L
PQKN
S
E
L
W
I
I
Q
K
K
T
L
Q
D
L
S
------
S
G
K
Q
K
L
D
S
F
Q
S
-----
L
E
S
I
L
E
I
L
R
D
S
K
N
Q
N
D
-----
E
K
-
Y
F
N
L
K
A
V
F
-
E
Q
L
D
K
E
E
Q
T
Y
F
L
E
--
Q
--
F
I
P
K
I
C
Q
L
--
V
L
---------
K
I
K
---
K
K
Q
L
K
N
Q
I
---------
P
------------
K
-
E
-
S
K
I
Y
E
A
A
F
S
R
E
E
I
S
Y
-
Y
---
V
S
C
-----
M
F
-------
L
C
I
L
K
D
Q
D
R
K
--------
I
Y
K
DFR---
L
I
Y
L
K
D
L
V
Q
Q
I
N
I
R
R
Q
E
K
I
K
C
F
Y
-
E
Y
L
K
Q
A
L
----------
D
F
S
E
K
E
S
K
E
V
V
I
--
F
Q
R
I
N
------
C
---
G
Q
L
E
----------------------
D
Y
E
N
W
-------
V
D
K
L
-------
K
A
I
K
L
K
------
N
V
Q
L
T
D
DK
L
I
E
D
F
P
G
T
---
L
Q
V
D
F
A
N
C
D
I
G
G
----
G
I
L
G
---
N
G
L
----
V
Q
E
E
I
R
F
-----------
C
V
C
P
E
M
L
V
S
L
----------------
L
V
F
D
Q
S
M
------------------------------------------
E
--
A
N
E
V
I
I
M
K
G
I
-----------------------
K
--
Q
Y
S
D
-----
Y
Q
GY
S
N
S
F
R
F
V
K
M
----
G
N
S
K
I
Q
K
Q
K
R
T
N
P
Q
T
-----
I
L
A
I
D
A
L
C
F
N
S
S
D
N
Q
F
S
-
E
V
N
----
V
S
R
----
E
L
N
K
S
Y
M
G
F
--
K
Q
E
D
Q
L
K
T
I
S
T
G
KWGCGAF
L
G
V
F
D
L
---
K
F
A
I
Q
W
I
A
---
S
S
R
S
N
K
K
M
I
I
C
T
F
Q
D
E
Q
T
T
K
Q
I
Q
Q
V
F
D
L
Y
K
Q
KN
A
S
I
F
L
K
-----
L
V
M
D
Y
P
N
S
K
Y
M
E
D
Y
T
L
L
E
Y
L
I
E
L
G
K
E
KA-----------------------------------------------------------------------------------
13
Fugue
75.27
12%
-140
- C5 -
3GF3
1
?
A:
[3-587]
-----------------------
M
Y
S
M
P
G
Y
F
Q
N
M
P
T
I
G
K
EL
V
N
P
N
P
E
N
E
Q
E
I
-----
K
A
V
E
S
D
I
H
E
S
I
K
K
A
L
D
-----
A
G
-
I
T
S
E
E
K
L
N
-
E
R
G
Q
L
S
A
M
Q
R
I
N
A
L
I
D
PG
T
W
C
P
L
N
S
L
--
F
N
PENNK
F
G
T
T
N
I
V
---
N
G
L
G
R
V
D
G
K
W
V
Y
--
I
V
A
S
DNKKMAGAWVPG
Q
-
A
-
E
N
L
I
R
C
S
D
A
A
K
M
M
---
H
---
L
P
L
-----
I
Y
-------
L
L
N
C
S
G
V
E
F
P
--------
N
Q
D
------
K
V
Y
P
N
R
R
G
G
G
T
P
F
F
R
N
S
E
L
N
Q
L
G
-
I
P
V
I
V
G
I
Y
G
T
N
P
A
G
G
G
Y
H
S
I
S
P
T
I
---
L
I
--
A
H
Q
D
A
N
M
----
A
VG-
G
A
G
A
E
---
Q
I
I
A
A
---------
Q
I
E
N
S
K
L
K
V
-------
P
A
P
G
S
V
----
P
I
H
Y
D
E
T
GFFREV
Y
Q
N
D
L
G
--
V
I
D
G
I
K
K
Y
I
S
Y
L
P
A
Y
N
L
E
F
F
R
V
D
----
T
P
K
A
---
P
Q
L
----
P
A
E
D
L
Y
S
I
I
PMNQK
R
P
Y
D
I
Y
--
E
V
I
A
R
L
F
DNS
E
F
S
E
Y
KKGYGPE
M
V
T
G
L
A
K
V
--
N
G
-
L
L
V
G
V
I
A
N
-
V
Q
-----
G
L
L
----
M
-------
N
Y
--
P
E
Y-
K
Q
N
S
V
G
I
G
G
K
-----------------------
L
--
Y
R
Q
G
-----
L
I
--
K
M
N
E
F
V
T
L
C
----
A
R
D
R
I
P
L
I
W
L
Q
D
T
T
G
IDVG
D
E
A
E
K
A
E
L
L
G
L
G
Q
S
L
I
Y
S
-
I
E
N
----
S
K
L
----
P
S
L
E
I
T
I
R
K
--
A
S
A
A
A
H
Y
V
L
G
G
--------
P
Q
G
N
N
T
---
N
V
F
S
I
G
T
G
---
A
C
------
E
Y
Y
V
M
P
G
E
T
A
A
N
A
M
Y
S
R
K
L
V
K
A
Q
--
P
I
I
G
K
M
-----
N
D
M
-
I
Q
M
Y
T
D
K
S
R
P
K
Y
C
T
E
K
GMVDEIVDMTE
V
R
P
Y
I
Q
A
F
T
E
A
A
Y
Q
NPQ
S
I
C
P
MHQML
T
P
R
S
T
R
E
F
E
T
F
G------------------------------------------
17
Fugue
75.19
14%
-162
- C3 -
3M6A
1
LON1_BACSU
A:
[7-531]
------------------TGEVQ
T
L
T
E
K
I
E
E
A
G
M
P
------
D
H
V
K
E
T
A
L
K
E
L
N
R
YEK
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
-----
W
--
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
--
E
H
H
G
L
E
K
V
K
E
R
I
-----
L
E
Y
L
A
V
Q
---
K
L
T
K
S
L
K
G
P
I
L
C
--
L
A
G
P
------------
P
G
V
-
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
---
V
R
I
-----
S
L
-------
G
G
R
I
I
Q
G
M
K
K
A
GKLN
P
V
F
L
L
D
EIDKMS
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
----------
A
T
A
N
N
L
A
---
T
I
--
P
G
P
L
R
D
R
----
M
---
E
I
I
N
I
A
G
Y
T
E
I
E
K
---------
L
E
I
V
K
D
H
L
L
-------
P
K
Q
I
K
E
H
GLK
K
S
N
L
Q
L
R
------
D
Q
A
I
L
D
--
I
I
R
Y
Y
-
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
----
R
K
A
A
---
K
A
I
V
AEE
R
K
R
I
T
V
T
-----------
E
K
--
N
L
Q
D
F
I
GKRIFRYGQA
E
T
E
D
--
Q
V
G
V
V
T
G
L
--
A
Y
-
T
T
V
G
G
D
T
L
-
S
I
-----
E
V
S
----
L
S
P
G
K
G
K
L
I
L
--
T
G
--
K
L
G
D
V
M
R
E
S
A
-----------------------
Q
--
A
A
F
S
-----
Y
V
--
R
S
K
T
E
E
L
G
I
----
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
-----
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
-
A
L
V
----
S
A
L
T
GRA
V
S
R
E
V
G
M
T
G
--
E
I
T
L
R
G
R
V
L
P
I
---------
G
G
L
K
E
---
K
A
L
G
A
H
R
A
GLT
T
I
------
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
--
I
L
A
---------------
S
H
L
D
E
V
L
E
H
A
L
V--------------------------------------------------------------------------------------------
15
Fugue
75.07
15%
-132
- C6 -
4WGV
-
?
A:
[5-399]
----------------------------------
V
------
G
Y
M
D
P
G
N
W
I
T
S
-----
M
Q
G
G
A
Q
--------
Y
G
-----
Y
T
-
L
L
F
V
I
L
I
S
-
S
L
A
A
M
L
L
Q
S
M
T
V
R
L
G
I
--
A
T
G
K
D
L
A
Q
--
M
T
-----
R
H
F
L
S
K
P
---
V
A
I
I
F
W
I
I
A
E
L
A
--
I
I
A
T
------------
D
-
I
-
A
E
V
I
G
S
A
I
A
L
D
L
I
---
F
GIP
L
I
V
-----
G
A
-------
L
I
T
V
F
D
V
F
L
L
--------
L
F
I
------
M
R
F
-
G
F
R
K
I
E
A
I
V
G
T
L
I
F
T
V
L
A
I
-
F
V
F
E
V
F
I
----------
S
S
P
Q
L
T
D
---
I
L
NG
F
V
P
H
K
E
I
----
V
---
T
N
Q
G
I
---
L
Y
I
A
L
---------
G
I
I
G
A
T
-
I
M
-------
P
H
N
L
Y
L
----
H
S
S
I
V
Q
S
------
R
K
----------
Y
D
R
H
D
N
E
E
K
A
Q
A
I
K
Y
A
T
I
D
----
S
N
L
Q
---
L
S
I
----
A
F
V
V
N
C
L
-----------
L
L
--
T
L
G
A
A
L
----------------
F
F
G
T
K
T
N
D
--
L
G
G
F
Y
D
L
Y
H
A
L
K
T
E
-----
P
V
L
----
G
-------
A
T
--
L
G
--
G
V
M
S
T
L
F
A
V
A
-----------------------
L
--
L
A
S
G
-----
Q
---
N
S
T
I
T
G
T
L
A
----
G
Q
I
V
M
E
G
F
L
R
L
S
----------------
I
P
N
W
L
R
R
L
I
-
T
R
S
----
L
A
V
----
I
P
V
I
I
C
L
I
I
--
F
K
G
N
S
E
K
I
E
Q
L
--------
L
V
F
S
Q
V
---
F
L
S
I
A
L
P
F
---
S
L
------
I
P
L
Q
L
A
T
S
N
K
K
L
M
G
P
F
I
N
K
T
W
----
V
N
I
I
S
W
-----
T
L
I
-
V
I
L
S
G
L
N
V
Y
--------------------------------------------------------------------------------------------------
4
HHSearch
70.75
11%
-145
- C6 -
3L1L
2
ADIC_ECO57
A:
[7-381]
-------------------------------------------------
A
H
K
-----
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
-----
S
G
-
V
F
L
L
P
A
N
L
-
A
S
T
G
G
-
I
A
I
Y
G
W
L
V
T
I
--
I
G
A
L
G
L
-
S
--
M
V
-----
Y
A
K
M
S
F
L
D--
P
S
P
G
G
S
Y
A
Y
A
R
R
--
C
F
G
P
------------
F
-
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
---
I
---
G
N
I
-----
A
M
-------
V
V
I
G
V
G
Y
L
S
Y
--------
F
F
P
------
I
L
K
D
-------
P
W
----
V
L
T
I
T
C
-
V
V
V
L
W
I
F
----------
V
L
L
N
I
V
G
---
P
K
--
M
I
T
R
V
Q
A
----
V
---
A
T
V
L
A
---
L
I
P
I
V
---------
G
I
A
V
F
G
W
F
W
-------
F
R
G
E
T
Y
----
M
A
----------------
A
--
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
----
V
V
K
N
---
P
K
-----
R
N
V
P
I
A
T
-----------
I
G
--
G
V
L
I
A
A
----------------
V
C
Y
V
L
S
T
T
--
A
I
-
M
G
M
I
P
N
A
A
-
L
R
VSAS-
P
F
G
----
D
-------
A
A
R
M
A
L
--
G
D
T
A
G
A
I
V
S
F
-----------------------
C
--
A
A
A
G
-----
C
L
--
G
S
L
G
G
W
T
L
L
----
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
-----
P
I
F
A
R
V
N
K
A
G
T
P
V
--
A
G
-
L
I
I
----
V
G
I
----
L
M
T
I
F
Q
L
S
S
--
I
S
P
N
A
T
K
E
F
G
L
--------
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
---
A
A
------
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
--
F
L
Y
C
I
W
-----
A
V
V
-
G
S
G
A
K
E
V
M
W
S
F
V
T
----------------------------------------------------------------------------------------------
14
Fugue
69.50
10%
-147
- C6 -
3GIA
7
Y609_METJA
A:
[3-435]
-----------------------------------------------
L
K
N
K
K
-----
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
-----
A
S
-
I
F
S
I
F
G
V
G
-
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
--
I
Y
A
L
L
V
A
Y
--
S
Y
-----
T
K
L
G
A
K
I
VSN
A
G
P
I
A
F
I
H
K
A
I
G
DN
I
I
T
G
------------
A
-
L
-
S
I
L
L
W
M
S
Y
V
I
S
I
A
---
L
---
F
A
K
-----
G
F
-------
A
G
Y
F
L
P
L
I
N
A
-------------------------------
P
I
N
T
F
N
I
A
I
-
T
E
I
G
I
V
A
----------
F
F
T
A
L
N
F
---
F
G
--
S
K
A
V
G
R
A
----
E
---
F
F
I
V
L
---
V
K
L
L
I
---------
L
G
L
F
I
F
A
G
L
-------
I
T
I
H
P
S
----
Y
V
I
P
D
L
A
------
P
S
A
V
S
G
--
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
HIEN
P
K
K
N
---
V
P
R
----
A
I
F
I
S
I
L
-----------
I
V
--
M
F
V
Y
V
G
----------------
V
A
I
S
A
I
G
N
LP
I
D
-
E
L
I
K
A
S
E
N
-
A
L
-----
A
V
A
----
A
-------
K
P
--
F
L
--
G
N
L
G
F
L
L
I
S
I
-----------------------
G
--
A
L
F
S
-----
I
S
--
S
A
M
N
A
T
I
Y
G
----
G
A
N
V
A
Y
S
L
A
K
D
---
G
-----
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
-
L
Y
I
----
T
S
A
----
L
G
V
L
F
A
L
L
F
--
N
M
E
G
V
A
S
I
T
S
A
----------
V
F
M
V
---
I
Y
L
F
V
I
L
S
---
H
Y
------
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
--
F
L
L
L
L
Y
-----
Y
Q
W
-
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
TK
R
T
F
S
NNMYVKS-------------------------------------------------------------------
19
Fugue
69.26
19%
-120
- C5 -
2QUB
-
?
A:
[1-615]
SHMGIFSYKDLD
E
N
A
S
K
A
L
F
S
D
A
L
A
I
S
T
Y
A
Y
H
N
I
-------
D
N
G
F
D
E
G
Y
H
Q
T
-----
G
F
G
L
G
L
P
L
T
L
I
T
A
L
I
G
S
TQ
S
Q
G
G
-
L
P
G
L
P
W
N
P
-
D
S
E
Q
A
A
Q
E
A
V
N
N
A
G
W
S
--
V
I
----
S
A
--
T
Q
-----
L
G
Y
A
G
K
T
---
D
A
R
G
T
Y
Y
G
E
T
A
G
--
Y
T
T
A
------------
Q
-
A
-
E
V
L
G
K
Y
D
S
E
G
N
L
T
---
A
---
I
G
I
-----
S
F
R
G
TSGPR
E
S
L
I
G
D
T
I
G
D
--------
V
I
N
------
D
L
L
A
G
F
G
P
K
G
---
Y
A
D
G
Y
T
L
K
A
F
-
G
N
L
L
G
D
V
----------
A
K
F
A
Q
A
H
---
G
L
--
S
G
E
D
V
V
V
SGHS
L
---
G
G
L
A
V
---
N
S
M
A
A
Q
SDANWGGF
Y
A
Q
S
N
Y
V
A
F
ASP
T
Q
Y
E
A
G
G
K
V
I
N
I
G
Y
E
N
D
P
V
F
R
------
A
L
D
G
T
S
--
L
--
T
L
P
S
L
G
V
H
D
A
P
H
T
S
A
T
N
N
I
V
----
N
F
N
D
---
H
Y
A
----
S
D
A
W
N
L
L
-----------
P
F
--
S
I
L
N
I
P
----------------
T
W
L
S
H
--------
L
P
F
F
Y
Q
D
G
-
L
M
-----
R
V
L
N
SEF
Y
-------
S
L
--
T
D
--
K
D
S
T
I
I
V
S
N
L
SNVTRGN
T
W
V
E
DLNRNA
E
T
H
S
G
P
T
--
F
I
I
G
S
D
G
N
D
L
I
--
K
G
G
K
G
N
D
Y
L
E
GRD
G
D
D
I
F
R
D
A
G
G
Y
N
L
I
A
-----
G
G
K
G
H
N
I
F
D
T
Q
Q
A
L
K
N
T
-
E
V
A
Y
DGN
T
L
Y
----
L
R
D
A
K
G
G
I
T
--
L
A
D
D
I
S
T
L
R
S
K
--------
E
---
T
S
---
W
L
I
F
N
K
E
V
---
D
H
------
Q
V
T
A
A
G
L
K
S
D
S
G
L
K
A
Y
A
A
A
T
G
G
D
--
G
D
D
V
L
Q
A
R
SHD
A
W
L
-
F
G
N
A
G
N
D
T
L
I
G
H
A
GGN
L
T
F
V
GGS
G
D
D
I
L
K
G
V
G
NG
N
T
F
L
F
S
G
DF
G
R
D
Q
L
Y
GFNAS
D
K
L
V
F
I
GTEGASGNIRDYATQQND
D
L
V
L
A
FGH
S
Q
V
T
L
I
GVSLDHISTDQVVLA
5
HHSearch
64.72
9%
-147
- C6 -
3GIA
6
Y609_METJA
A:
[3-373]
-----------------------------------------------
L
K
N
K
K
-----
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
-----
A
S
-
I
F
S
I
F
G
V
G
A
K
I
A
G
-
R
N
L
P
E
T
F
I
L
S
G
--
I
Y
A
L
L
-
V
A
--
Y
S
-----
Y
T
K
L
G
A
K
I
--
V
S
N
A
G
P
I
A
F
I
H
K
--
A
I
G
D
------------
N
-
I
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
---
I
---
S
I
A
-----
L
F
-------
A
K
G
F
A
G
Y
F
L
P
--------
L
I
N
------
A
P
I
N
-------
T
F
---
N
I
-
A
I
T
E
-
I
G
I
V
A
F
F
----------
T
A
L
N
F
F
G
---
S
K
--
A
V
G
R
A
E
F
----
F
---
I
V
L
V
K
---
L
L
I
L
G
---------
L
F
I
F
A
G
L
I
T
-------
I
H
P
S
Y
V
----
I
P
--
D
L
A
------
P
S
A
V
S
G
--
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
----
H
I
E
N
---
P
K
-----
K
N
V
P
R
A
I
-----------
F
I
--
S
I
L
I
V
M
----------------
F
V
Y
V
G
V
A
I
--
S
A
-
I
G
N
L
P
I
D
E
-
L
I
K
A
SEN
A
L
A
----
V
-------
A
A
--
K
P
FL
G
N
L
G
F
L
L
I
S
I
-----------------------
G
--
A
L
F
S
-----
I
S
--
S
A
M
N
A
T
I
Y
G
----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
-----
E
F
F
E
R
K
V
W
F
K
-
S
T
-
E
G
L
-
Y
I
T
----
S
A
L
-------
G
V
L
F
A
---
L
L
F
N
M
E
G
V
A
S
I
--------
T
S
-
A
V
F
---
M
V
I
Y
L
F
V
I
---
L
S
------
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
--
G
V
F
L
L
L
-----
L
Y
Y
-
Q
W
I
T
N
R
F
V
F
Y
G
I
I
----------------------------------------------------------------------------------------------
16
Fugue
56.66
20%
-121
- C5 -
4BOU
-
OTUD3_HUMAN
A:
[1-141]
-------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
------------
E
-
F
-
V
S
F
A
N
Q
L
Q
A
L
G
L
K
---
L
---
R
E
V
PGDGN
C
L
-------
F
R
A
L
G
D
Q
L
E
G
--------
H
S
R
------
N
H
L
K
H
R
Q
E
T
V
D
Y
M
I
K
Q
R
E
D
F
E
P
F
-
V
--------------------
E
D
D
---
I
P
--
F
E
K
H
V
A
S
----
L
A
KP
G
T
F
A
G
---
N
D
A
I
V
---------
A
F
A
R
N
H
Q
L
----------
N
V
V
I
----
H
Q
L
N
A
P
L
------
W
Q
I
R
G
T
--
E
K
S
S
V
R
E
L
H
I
A
Y
R
Y
G
E
----
H
Y
D
----
S
V
R
R
---
I
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
37.20
46%
60
- C7 -
4JBS
1
ERAP2_HUMAN
A:
[276-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
S
S
G
V
K
V
S
I
Y
A
----
S
P
D
K
---
R
N
Q
----
T
H
Y
A
L
Q
A
-----------
S
L
--
K
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
36.63
28%
299
* C5 *
2M04
-
B:
[1-25]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
-----
Q
W
-------
A
R
E
I
G
A
Q
L
R
R
--------
M
A
D
------
D
L
N
A
Q
Y
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
35.13
9%
-98
- C6 -
2JLN
-
?
A:
[22-181]
-----------------------------------------------
Y
A
E
R
S
-----
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
-----
V
A
I
F
I
A
A
G
Q
M
T
-
S
S
F
Q
V
W
Q
V
I
V
A
I
A
A
G
C
--
T
I
A
V
I
L
L
---
F
F
-----
T
Q
S
A
A
I
R
----
W
G
I
N
F
T
V
A
A
R
M
--
P
F
G
I
------------
R
-
G
-
S
L
I
P
I
T
L
K
A
L
L
S
L
---
F
---
W
F
G
-----
F
Q
-------
T
W
L
G
A
L
A
L
D
E
--------
I
T
R
------
L
L
T
G
F
--
T
--------
N
L
P
L
W
I
V
-
I
F
G
A
I
Q
V
----------
V
T
T
-
F
Y
G
---
I
T
--
F
I
R
W
M
N
V
----
F
---
A
S
P
V
L
---
L
A
M
G
V
---------
Y
M
V
Y
L
M
L
D
G
-------
A
D
V
S
L
G
----
E
V
M
S
M
G
G
------
E
N
P
G
M
P
--
F
S
T
A
I
M
I
F
V
G
G
W
I
A
V
V
V
S
I
H
D
I
V
----
K
E
C
K
---
V
D
P
----
N
A
S
R
E
G
Q
-----------
T
K
--
A
D
A
R
Y
A
----------------
T
A
Q
W
L
G
M
V
--
P
A
-
S
I
I
F
G
F
I
G
-
A
A
-----
S
M
V
----
L
-------
V
G
--
E
W
--
N
P
V
I
A
I
T
E
V
V
-----------------------
G
--
G
V
S
I
-----
P
M
--
A
I
L
F
Q
V
F
V
L
----
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
-----
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
-
V
I
V
----
S
A
V
----
V
G
L
L
M
M
P
W
Q
--
F
A
G
V
L
N
T
F
L
N
L
--------
L
A
S
A
L
G
---
P
L
A
G
I
M
I
S
---
D
Y
------
F
L
V
R
R
R
R
I
S
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
--
R
G
V
N
W
V
-----
A
L
A
-
V
Y
A
V
A
L
A
V
S
F
L
T
P
----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
34.93
46%
47
* C7 *
3SE6
1
ERAP2_HUMAN
A:
[276-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
S
S
G
V
K
V
S
I
Y
A
----
S
P
D
K
---
R
N
Q
----
T
H
Y
A
L
Q
A
-----------
S
L
--
K
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
33.11
46%
51
- C7 -
4E36
1
ERAP2_HUMAN
A:
[276-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
S
S
G
V
K
V
S
I
Y
A
----
S
P
D
K
---
R
N
Q
----
T
H
Y
A
L
Q
A
-----------
S
L
--
K
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
25.86
23%
463
- C6 -
1TER
1
TERT_APIME
A:
[8-20]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
I
P
H
---
M
C
------
W
K
K
C
G
K
K
--------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
21.53
20%
-114
- C6 -
2WSW
-
?
A:
[88-112]
-------------------------------------------------
K
P
E
-----
F
S
T
A
S
W
I
F
M
M
F
A
S
C
T
S
-----
A
A
-
V
L
F
W
G
S
I
E
-
I
Y
Y
Y
I
S
S
P
P
F
G
M
E
G
Y
S
--
A
P
A
K
E
I
G
L
--
A
Y
-----
S
L
F
H
W
G
P
---
L
P
W
A
T
Y
S
F
L
S
V
A
--
F
A
Y
F
------------
F
-
F
-
V
R
K
M
E
V
I
R
P
S
S
T
L
---
V
---
P
L
V
-----
G
E
-------
K
H
V
N
G
L
F
G
T
V
--------
V
D
N
------
F
Y
L
V
A
L
I
L
A
M
G
T
S
L
G
L
A
T
P
L
V
T
E
-
C
I
Q
Y
L
F
G
----------
I
P
H
T
L
Q
L
---
D
A
--
I
I
I
S
C
W
I
----
L
---
L
N
A
I
C
---
V
A
F
G
L
---------
Q
K
G
V
K
I
A
S
D
-------
V
R
T
Y
L
S
----
F
L
M
L
G
W
V
------
F
I
V
G
G
A
--
S
F
I
V
N
Y
F
T
D
S
V
G
T
L
L
M
Y
M
P
R
M
L
F
----
Y
T
D
P
---
I
G
K
----
G
G
F
P
Q
A
W
-----------
T
V
--
F
Y
W
A
W
W
----------------
V
I
Y
A
I
Q
M
S
--
I
F
-
L
A
R
I
S
K
G
R
-
T
V
-----
R
E
L
----
C
-------
L
G
--
M
V
--
S
G
L
T
A
G
T
W
L
I
-----------------------
W
--
T
I
L
G
-----
G
N
--
T
L
Q
L
I
D
Q
N
I
----
L
N
I
P
Q
L
I
D
Q
Y
G
V
P
R
A
-----
I
I
E
T
W
A
A
L
P
L
S
T
A
T
M
W
G
-
F
F
I
----
L
C
F
----
I
A
T
V
T
L
I
N
A
--
C
S
Y
T
L
A
M
S
T
C
R
--------
S
M
K
E
G
A
---
D
P
P
L
L
V
R
I
---
G
W
------
S
V
L
V
G
I
I
G
I
I
L
L
A
L
G
G
L
K
P
I
Q
T
A
--
I
I
A
G
G
C
-----
P
L
F
-
F
V
N
I
M
V
T
L
S
F
I
K
D
----------------------------------------------------------------------------------------------
12
HHSearch
21.17
19%
97
* C6 *
3BO0
-
SECE_METJA
B:
[12-51]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
T
----
E
V
R
K
V
I
W
P
T
R
----
K
P
T
K
D
E
Y
-----------
L
A
--
V
A
K
V
T
A
----------------
L
G
I
S
L
L
G
I
--
I
G
-
Y
I
I
H
V
P
A
T
-
Y
I
-----
K
G
I
----
L
-------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
6.00
0%
1034
- C1 -
2ZJS
-
SECE_THET8
E:
[12-28]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
A
----
E
L
A
R
VTW
P
T
R
----
E
Q
V
V
E
G
T
-----------
Q
A
--
I
L
L
F
T
L
----------------
A
F
M
V
I
L
G
L
--
Y
D
-
T
V
F
R
F
L
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------