@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S38A9_HUMAN: (2015-12-10 )
MANMNSDSRHLGTSEVDHERDPGPMNIQFEPSDLRSKRPFCIEPTNIVNVNHVIQRVSDHASAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLQSYTEGYGKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIILMGLLTLYCCYRVVKSRTMMFSLDTTSWEYPDVCRHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSAGSGGHPDNSSMIFYANDTGAQQFEKWWDKSRTVPFYLVGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFLVTFKAVRLGFHLEFHWFIPTEFFVPEIRFQFPQLTGVLTLAFFIHNCIITLLKNNKKQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLSKDCIEQNFLDNFPSSDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISLHQEERLTWPKLIFHVFIIILGVANLIVQFFM
Atome Classification :
(18 SA)
---------.........10.---.......20.....-----------------------------...---30........40........50-----........60........70........80.-..--------.....90...------.....-100.......110------.......120.---------------......130.-------.-.....-140..-.....150--........160.......170.-.----.....180-.......190.....-..200.------......210.......220.......230.......240-------------------........---.250.......260..--.....270.......280.....------..290.......300.....------------..310.-----------------------------......320..-----.....330...-.-...340...-------....350..----.....--360..------------.....370...-------....380-------.......-.-.390.......400.......410.........420.......430..--...------..440...---....450---------........460.----------......470.....---------.-------.480.......490.......500...--....510..--.....520-----........530.......540.......550.......560---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MANMNSDSRHLG---TSEVDHERDPGP
M
N
-----------------------------
I
Q
F---EPSDLRSKR
P
F
C
IEPT
N
I
V
N
V
N
-----
H
V
I
Q
R
V
S
D
H
A
S
A
M
N
K
R
I
H
Y
Y
SRLTTPADKAL-IA--------PDHVVPAPE
E
------
C
Y
V
YS-PLGS
A
Y
K
L
Q
S
Y
T
E------GYGKN
T
S
L
V
T
I
---------------
F
M
I
W
N
T
MMG
T
-------
S
-
I
LSIP-WGIKQ-AGF
T
T
G
M
---
C
V
I
I
L
M
G
L
L
T
L
Y
C
C
Y
R
V
VKSR
T
-
M
----
M
F
S
LDTTS-WE
Y
P
D
V
C
R
H
Y
F
GSF
G
-
Q
W
S
S
L
L
------
F
S
L
V
S
L
I
G
A
M
I
V
Y
W
V
L
M
S
N
F
LFN
T
G
K
F
I
F
N
F
I
H
HIND---------------------T
D
T
I
L
STN---NSN
P
V
I
CPSAGSGGHP--DNS
S
M
I
F
Y
ANDT
G
A
Q
Q
F
E
K
W
W
D
K------SRT
V
P
F
Y
L
V
G
L
L
L
P
L
LNFKS------------P
S
F
F
S
K
-----------------------------
F
N
I
L
G
T
V
S
V
L
Y
-----
L
I
F
L
V
T
F
K
A
V
R
-
L
-
G
F
H
L
E
F
H
W
F
-------I
P
T
EFFV
P
E
----
I
R
F
QF--P
Q
L
T
G
------------
V
L
T
L
A
F
F
I
H
N
C
-------
I
I
T
L
L
---------KNNKKQE-N-
N
V
R
D
L
C
I
A
Y
M
L
V
T
L
T
Y
L
Y
I
G
V
L
--
V
F
ASFPSPPL
S
K
D
C
I
E
Q
N
F
L
DNFP--S
S
D
------
T
L
S
F
I
A
R
I
---
F
L
L
F
Q
M
----------
M
T
V
Y
P
L
L
G
Y
L
A
R
----------
V
Q
L
L
G
H
I
F
G
D
I
Y
P
S
---------
I
-------
F
H
V
L
I
L
N
L
I
I
V
G
A
G
V
I
M
A
C
FYPNIG
G
I
--
I
R
YSGA
A
C
G
--
L
A
F
V
F
I
Y
------
P
S
L
I
Y
I
ISLH
Q
E
ERL
T
W
P
K
L
I
F
H
V
F
I
I
I
L
G
V
A
N
L
I
V
Q
F
FM----------
19
Fugue
89.50
17%
-132
- C1 -
4R3Z
-
SYRC_HUMAN
B:
[17-675]
DV
L
V
S
E
C
S
A
R
L
L
Q
Q
E
E
E
I
K
S
L
---
T
A
E
I
D
R
L
K
N
C
G
C
L
G
-----------------------------
A
S
P
---
N
L
E
Q
L
Q
E
E
N
L
K
L
K
Y
R
L
N
I
L
R
K
S
-----
L
Q
A
E
R
N
K
P
T
----
K
N
M
I
N
I
I
S
R
L
Q
E
V
F
G
H
A
I
-
K
A
A
Y
PDLENP
P
L
L
V
T
P
S
Q
Q
A
------
K
F
G
D
Y
-
Q
C
N
S
A
M
G
I
S
Q
M
L
K
------
T
K
E
Q
K
V
N
P
R
E
I
---------------
A
E
N
I
T
K
H
L
P
D
-------
N
-
E
C
I
E
K
-
V
E
I
A
G
-
P
G
F
I
N
V
H
---
L
R
K
D
F
V
S
E
Q
L
T
S
L
L
V
N
G
V
Q
L
P
A
-
L
GEN
K
K
V
I
V
D
F
S
S
----
P
N
I
A
K
E
-
M
H
V
G
H
-
L
R
S
T
I
I
------
G
E
S
I
S
R
L
F
E
F
A
G
Y
D
V
L
R
L
N
H
V
G
D
W
G
T
Q
F
G
M
L
I
A
H
L
Q
D
K
FPDYLTVSPPIGD
L
Q
V
F
Y
K
E
S
K
K
R
F
D
T
E
E
E
F
K
K
R
A
Y
Q
C
V
V
L
L
Q
G
K
N
P
--
D
I
T
K
A
W
K
L
I
C
D
V
S
R
Q
E
L
N
K
I
Y
D
A
L
D
V
S
L
I
E
R
G
E
S
F
Y
Q
D
R
M
N
D
I
V
K
E
F
E
D
------------
R
G
F
V
Q
V
D
DG
R
K
I
V
F
V
PGCS
I
P
L
T
IVKSDGGYT
Y
D
T
S
D
L
A
A
I
K
Q
R
L
F
EEKAD
M
I
I
Y
V
V
D
N
G
Q
S
-
V
-
H
F
Q
T
I
F
A
A
A
-------
Q
M
I
G
W
Y
D
P
K
VTRV
F
H
A
G
F
--
G
V
V
L
G
EDKKKFKTRSGE
T
V
R
L
M
D
L
L
G
E
G
-------
L
K
R
S
M
D
K
L
K
E
KERD
K
V
L
T
A
E
E
-
L
-
N
A
A
Q
T
S
V
A
Y
G
C
I
K
Y
A
D
L
S
H
N
R
L
ND
Y
I
F
S
F
D
K
M
L
D
D
R
G
N
T
A
A
Y
L
L
Y
A
F
T
--
R
I
R
------
S
I
A
R
L
A
N
I
D
E
E
M
L
Q
K
A
A
----------
R
E
T
K
I
L
L
D
H
E
K
E
----------
W
K
L
G
R
C
I
L
R
--
F
P
E
---------
I
-------
L
Q
K
I
L
D
D
L
F
L
H
T
---
L
C
D
Y
I
Y
--------------
E
L
A
--
T
A
F
T
E
F
Y
------
D
S
C
Y
C
V
E
K
D
R
Q
T
G
K
I
--
L
K
V
N
M
W
R
M
L
L
C
E
A
V
A
A
V
M
A
K
G
F
D
I
L
G
I
K
P
V
Q
RM
18
Fugue
84.65
18%
-98
- C3 -
4Q05
-
?
A:
[34-360]
-------------------
E
N
---
S
W
Q
I
G
P
R
T
L
P
A
P
S
G
-----------------------------
A
S
D
---
V
L
Y
N
I
I
S
K
T
P
---
T
P
V
P
T
I
N
L
N
-----
L
V
P
R
T
E
S
E
W
R
A
A
I
T
Q
L
D
E
G
K
V
D
M
A
R
E
I
S
K
Q
L
S
V
S
--------
V
E
H
G
V
I
E
G
V
S
------
V
Y
Y
V
T
-
P
V
E
V
A
P
D
L
E
D
K
-----------------------------------
L
F
V
H
T
H
G
G
A
-------
F
-
V
L
-----
N
G
G
E
-
A
G
T
I
E
A
I
---
V
I
A
T
L
A
K
V
R
V
L
S
I
D
Y
R
M
P
P
S
H
P
------------
A
P
-
A
A
R
D
D
V
F
T
V
Y
Q
H
L
L
K
-
Q
G
S
A
Q
K
------
I
A
L
G
G
S
S
G
G
A
N
L
T
M
G
L
V
Q
H
L
I
E
Q
E
V
D
L
P
------------------------------
G
A
L
F
L
G
T
P
---
G
A
D
M
S
K
T
G
D
S
Y
Y
I
N
D
G
--
I
D
R
N
L
V
T
Y
--
D
G
F
L
E
A
A
V
R
L
Y
A
N
------
G
R
D
L
K
D
P
L
V
S
P
L
Y
G
D
L
H
----------------
G
F
P
P
T
-----------------------------
F
L
I
T
G
T
R
D
L
L
L
-----
S
A
T
V
R
T
H
I
K
L
R
-
Q
S
G
V
V
A
D
L
F
V
Y
E
GIAHGD
Y
A
V
D
L
T
A
P
E
----
T
Q
H
A
F
--
A
E
L
N
A
------------
F
L
L
Q
H
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
81.92
15%
-115
* C3 *
3WOL
7
DAPB2_PSEMX
A:
[1-696]
GEGMWVPQQ
L
P
E
I
A
G
P
L
K
K
A
G
LKL
S
P
Q
Q
I
S
D
L
T
G
D
P
M
G
AVVALGG
C
T
A
S
F
VSPNG
L
V
V
T
N
HHCA
Y
G
A
I
Q
L
N
ST
A
E
N
N
L
I
K
N
G
F
N
A
P
T
T
A
D
E
V
S
A
G
PN
A
R
V
F
V
L
D
E
I
T
D
V
T
K
D
A
K
A
A
I
A
A
A
G
D
D
A
L
A
R
T
K
A
L
-
E
A
--------
F
E
K
K
L
I
A
D
C
E
AEAG
F
R
C
R
L
Y
S
F
S
G
G
N
T
Y
R
L
F
K
N
L
E
IKDVRL
A
Y
A
P
P
G
S
V
G
K
F
GGDIDNWMWPRHTGD
F
A
F
Y
R
A
Y
V
G
K
DG
K
P
A
A
F
S
-
K
D
N
V
P
-
Y
Q
P
K
H
W
L
K
F
A
D
Q
P
------
L
G
A
G
D
F
V
M
V
A
G
Y
P
G
S
T
N
R
Y
A
L
----
A
A
E
F
D
N
T
A
Q
W
T
Y
P
T
I
A
R
H
Y
K
N
Q
I
A
-
M
V
E
A
A
G
------
K
Q
N
A
D
I
Q
V
K
Y
A
A
T
M
A
G
W
N
N
T
S
K
N
Y
-
D
G
Q
L
E
G
F
K
R
I
D
A
---------------------
A
G
Q
K
L
R
E
E
---
A
A
V
L
G
W
L
K
G
Q
G
A
K
G
Q
P
A
L
D
A
H
A
K
L
L
D
L
L
E
Q
S
K
A
T
R
D
R
D
L
T
L
------
A
L
F
N
N
T
A
M
L
G
S
A
T
Q
L
Y
R
L
S
I
E
R
E
K
PNAERESG
Y
Q
E
R
D
L
-----------------------------
P
A
I
E
G
G
L
K
Q
L
E
-----
R
R
Y
V
A
A
M
D
R
Q
L
-
Q
-
E
Y
W
L
N
E
Y
I
K
-------
L
P
A
D
Q
R
V
A
A
----
V
D
A
W
L
GG
N
D
A
A
A
------------
V
K
R
A
L
D
R
L
A
G
T
KLGS
T
E
E
R
L
K
W
F
---------
A
A
D
R
K
A
F
-
E
-
A
S
N
D
P
A
I
Q
Y
A
V
A
V
M
P
T
L
L
K
L
E
Q
--
E
R
K
T
R
A
G
E
N
L
A
A
R
P
V
Y
L
Q
A
L
A
D
Y
K
--
K
S
Q
G
E
F
V
Y
P
D
A
N
L
S
L
R
I
---
T
F
G
N
V
M
G
Y
A
PKDG
M
E
Y
T
P
F
T
T
L
E
G
V
V
A
K
ETGQDPFDSP
K
A
L
L
D
A
V
A
A
K
R
Y
G
G
---------
L
EDKRIGS
V
P
V
N
Y
L
S
D
L
D
I
T
G
G
N
S
G
S
P
V
L
D
A
H
G
K
L
V
G
L
A
F
D
G
N
W
E
S
--
V
S
S
N
W
V
F
D-----
P
K
M
T
R
M
I
A
V
D
-------
G
R
Y
L
R
W
I
M
Q
E
V
Y
P
A
P
Q
L
L
K
E
M
N
V
----------
12
Fugue
81.16
9%
-105
* C4 *
1MT5
1
FAAH1_RAT
A:
[1-537]
-ARGA
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
---
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
-----------------------------
S
E
A
---
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
-
S
G
E
L
S
P
E
-----
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
-
S
Q
--------
A
P
R
Q
G
L
L
Y
----------------
G
V
P
V
S
L
K
E
C
F
S
------
Y
K
G
H
D
S
T
L
G
L
S
---------------
L
N
E
G
M
P
S
E
S
D
-------
C
---
V
V
V
-
Q
V
L
K
L
-
Q
G
----------
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
-
P
----
L
F
G
Q
T
M
N
P
-
W
K
S
S
---
K
S
P
G
G
S
S
G
-
G
E
G
A
L
I
G
S
GGSP
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
------
G
I
C
G
L
K
P
T
G
N
R
L
S
---------------------
K
S
G
L
K
G
C
V
---
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
--
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
---
D
------
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
------------
V
G
Y
Y
E
T
-----------------------------
D
N
Y
T
M
P
S
P
A
M
R
-----
R
A
L
I
E
T
K
Q
R
L
E
A
A
-
G
H
T
L
I
P
F
L
P
-------
N
N
I
P
Y
A
L
E
V
----
L
S
A
G
G
--
L
F
S
D
G
------------
G
R
S
F
L
Q
N
F
K
G
D
-------
F
V
D
P
C
---------
L
G
D
L
I
L
I
-
L
-
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
--
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
--
R
Q
S
------
V
I
A
Q
W
K
A
M
---
N
L
D
V
L
L
----------
T
P
M
L
G
P
A
L
D
L
N
T
----------
P
G
R
A
--
T
G
A
I
S
Y
T
V
---------
L
-------
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
--
K
G
Y
F
G
D
I
W
D
--
I
I
L
K
K
A
M
KNSVG
L
P
V
A
V
Q
C
V
A
L
P
W
Q
------------
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
----------
1
HHSearch
80.99
13%
-134
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
K
V
G
L
I
P
V
T
---------------
L
M
V
S
G
A
I
M
G
S
-------
G
-
V
F
L
L
P
-
A
N
L
A
S
-
T
G
G
-
I
A
I
---
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
-
L
----
D
P
S
----
P
-
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
------
L
Y
W
L
A
C
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
----------------------------------------------------------------------------
K
D
P
W
V
L
--------
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
------------
P
K
M
I
T
R
-----------------------------
V
Q
A
V
A
T
V
L
A
L
I
-----
P
I
V
G
I
A
V
F
G
W
F
-
W
-
F
R
G
E
T
Y
M
-
A
-----------------------
A
I
--
Q
S
T
L
N
------------
V
T
L
W
S
F
I
G
V
E
S
-------
A
S
V
A
A
---------
G
V
V
K
N
P
K
-
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
--
I
M
G
M
I
P
N
A
A
L
R
V
--
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
------
T
A
G
A
I
V
S
F
---
C
A
A
A
G
C
----------
L
G
S
L
G
G
W
T
L
L
A
G
----------
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
IFARVNKAG
T
-------
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
A
T
K
E
--
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
------
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
----------
2
HHSearch
58.80
15%
-128
- C2 -
3GIA
3
Y609_METJA
A:
[3-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
------
K
N
K
K
L
S
L
W
E
A
V
---------------
S
M
A
V
G
V
M
I
G
A
-------
S
-
I
F
S
I
F
G
V
G
A
K
I
-
A
G
R
-
N
L
P
---
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
-
K
----
I
V
S
----
N
-
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
------
L
L
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
----------------------------------------------------------------------------
I
N
T
F
N
I
--------
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
------------
S
K
A
V
G
R
-----------------------------
A
E
F
F
I
V
L
V
K
L
L
-----
I
L
G
L
F
I
F
A
G
L
I
-
T
-
I
H
P
S
Y
V
-
I
-----------
P
D
L
A
P
S
----
A
V
S
G
M
--
I
F
A
S
A
------------
I
F
F
L
S
Y
M
G
F
G
V
-------
I
T
N
A
S
---------
E
H
I
E
N
P
K
K
N
-
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
--
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
--
F
L
G
------
N
L
G
F
L
L
I
S
---
I
G
A
L
F
S
----------
I
S
S
A
M
N
A
T
I
Y
G
G
----------
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
---------
E
-------
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
--
F
N
M
E
G
V
A
S
I
--
T
S
A
V
F
M
V
------
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
----------
16
Fugue
38.40
10%
114
- C2 -
2QA7
-
HIP1_HUMAN
A:
[371-469]
----------
D
E
K
D
H
L
I
E
R
L
Y
---
R
E
I
S
G
L
K
A
Q
L
E
N
M
K
-----------------------------
T
E
S
---
Q
R
V
V
L
Q
L
K
G
H
V
S
E
L
E
A
D
L
A
E
Q
Q
-----
H
L
R
Q
Q
A
A
D
D
C
E
F
L
R
A
E
L
D
E
L
R
R
Q
R
E
D
T
E
K
A
Q
-
R
S
--------
L
S
E
I
E
R
K
A
Q
A
------
N
E
Q
R
Y
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
Fugue
37.94
12%
153
- C2 -
4JPN
-
H_BPPHS
A:
[2-76]
--------------------
V
---
D
A
G
F
E
N
Q
K
E
L
T
K
M
Q
-----------------------------
L
D
N
---
Q
K
E
I
A
E
M
Q
N
E
T
Q
K
E
I
A
G
I
Q
S
A
T
-----
S
R
-
Q
N
T
K
D
Q
V
Y
A
Q
N
E
M
L
A
Y
Q
Q
K
E
S
T
A
R
V
A
S
I
-
M
E
--------
N
T
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
Fugue
33.42
10%
152
- C2 -
1IC2
-
TPM1_CHICK
A:
[1-79]
------------
M
D
A
I
K
K
K
M
Q
---
M
L
K
L
D
K
E
N
A
L
D
R
A
E
-----------------------------
Q
A
E
---
A
D
K
K
A
A
E
E
R
S
K
Q
L
E
D
E
L
V
A
L
Q
K
-----
K
L
K
G
T
E
D
E
L
D
K
Y
S
E
S
L
K
D
A
Q
E
K
L
E
L
A
D
K
K
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
30.20
4%
131
* C2 *
2NO2
-
HIP1_HUMAN
A:
[480-581]
--------------
G
S
H
A
D
L
L
---
R
K
N
A
E
V
T
K
Q
V
S
M
A
R
-----------------------------
Q
A
Q
---
V
D
L
E
R
E
K
K
E
L
E
D
S
L
E
R
I
S
D
Q
G
Q
-----
R
K
T
Q
E
Q
L
E
V
L
E
S
L
K
Q
E
L
A
T
S
Q
R
E
L
Q
V
L
Q
G
S
L
-
E
T
--------
S
A
Q
S
E
A
N
W
A
A
------
E
F
A
E
L
-
E
K
E
R
D
S
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
28.78
9%
-76
- C2 -
2JLN
-
?
A:
[57-133]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
W
Q
V
I
---
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
-
R
----------
W
G
-
I
N
F
T
V
A
A
R
M
P
F
G
I
R
G
-
S
L
I
P
I
T
------
L
K
A
L
L
S
L
F
W
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
T
G
F
T
N
L
P
L
W
---------------------
I
V
I
F
G
A
I
Q
---
V
V
T
T
F
Y
G
I
T
F
I
R
W
M
N
V
--
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
------
S
L
G
E
V
M
S
M
G
G
E
N
P
G
M
P
F
S
T
A
------------
I
M
I
F
V
G
-----------------------------
G
W
I
A
V
V
V
S
I
H
D
-----
I
V
K
E
C
K
V
D
P
N
A
-
S
-
R
E
G
Q
T
K
A
D
A
-------
R
Y
A
T
A
Q
W
L
G
----
M
V
P
A
S
--
I
I
F
G
F
------------
I
G
A
A
S
M
V
L
V
G
E
-------
W
N
P
V
I
---------
A
I
T
E
V
V
G
-
G
-
V
S
I
P
M
A
I
L
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
--
A
A
N
L
L
S
P
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
--
V
I
V
------
S
A
V
V
G
L
L
M
---
M
P
W
Q
F
A
----------
G
V
L
N
T
F
L
N
L
L
A
S
----------
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
---------
L
-------
V
R
R
R
R
I
S
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
G
V
N
W
V
--
A
L
A
V
Y
A
V
A
L
--
A
V
S
F
L
T
P
------
D
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
----------
10
HHSearch
27.05
17%
349
- C2 -
3VC8
-
R1AB_CVMA5
A:
[22-45]
----------------------------------------------------------------------------------------------
N
-----
S
V
S
D
V
A
F
N
R
Y
L
S
L
Y
N
K
Y
R
Y
F
S
G
K
M
D
T
A
A
Y
R
E
-
A
A
--------
C
S
Q
L
A
K
A
M
E
T
------
F
N
H
N
N
-
G
N
D
V
L
Y
Q
P
P
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
26.68
13%
384
- C2 -
3GZF
-
R1AB_FIPV
A:
[32-55]
----------------------------------------------------------------------------------------------
N
-----
S
T
S
L
D
R
I
K
S
Y
A
N
S
F
N
K
Y
K
Y
Y
T
G
S
M
G
E
A
D
Y
R
M
-
A
C
--------
Y
A
H
L
G
K
A
L
M
D
------
Y
S
V
S
R
-
N
D
K
L
Y
T
P
P
T
V
S
V
N
------
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
24.45
5%
-73
- C2 -
3DH4
1
?
A:
[51-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
A
G
K
S
L
P
W
W
A
V
G
---------------
A
S
L
I
A
A
N
I
S
A
-------
E
Q
F
I
G
M
S
-
G
S
G
Y
S
-
I
G
L
A
I
A
S
---
Y
E
-
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
-
E
---------
K
G
I
-
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
-
K
T
I
L
A
V
------
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
P
L
M
Y
S
I
L
G
L
---------------------
A
L
F
A
L
V
Y
S
---
I
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
--
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
------
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
------------
Y
M
N
L
P
G
-----------------------------
I
A
V
L
I
G
G
L
W
V
A
-----
N
L
Y
Y
W
G
F
N
Q
Y
I
-
I
-
Q
R
T
L
A
A
K
S
V
-------
S
E
A
Q
K
G
I
V
F
----
A
A
F
L
K
--
L
I
V
P
F
------------
L
V
V
L
P
G
I
A
A
Y
V
-------
I
T
S
D
P
---------
Q
L
M
A
S
L
G
-
D
-
I
A
A
T
N
L
P
S
A
A
N
A
D
K
A
Y
P
W
L
T
Q
F
--
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
--
L
N
S
------
T
A
T
I
F
T
M
D
---
I
Y
K
E
Y
I
----------
S
P
D
S
G
D
H
K
L
V
N
V
----------
G
R
T
A
A
V
V
A
L
I
I
A
C
L
---------
I
-------
A
P
M
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
--
V
F
L
L
G
L
F
W
K
--
K
T
T
S
K
G
A
------
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
----------
7
HHSearch
22.69
15%
-86
- C2 -
2A65
2
?
A:
[6-69]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
W
A
T
R
L
G
L
I
---------------
L
A
M
A
G
N
A
V
G
L
-------
G
N
F
L
R
F
P
-
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
-
A
----
Q
G
H
G
T
T
P
A
-
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
-
V
F
G
L
W
I
------
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
G
F
A
I
K
F
L
V
G
L
V
P
E
P
P
P
T
D
P
D
S
---------------------
I
L
R
P
F
K
E
F
---
L
Y
S
Y
I
G
V
P
K
G
D
E
P
I
L
K
--
P
S
L
F
A
Y
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
------
I
S
K
G
I
E
R
F
A
K
I
A
M
P
T
L
F
I
L
A
------------
V
F
L
V
I
R
-----------------------------
V
F
L
L
E
T
P
N
G
T
A
-----
A
D
G
L
N
F
L
W
T
P
D
-
F
-
E
K
L
K
D
P
G
V
W
-------
I
A
A
V
G
Q
I
F
F
----
T
L
S
L
G
--
F
G
A
I
I
------------
T
Y
A
S
Y
V
R
K
D
Q
D
-------
I
V
L
S
G
---------
L
T
A
A
T
L
N
-
E
-
K
A
E
V
I
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
--
N
A
V
A
I
A
K
A
G
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
--
T
A
G
------
G
T
F
L
G
F
L
W
---
F
F
L
L
F
F
----------
A
G
L
T
S
S
I
A
I
M
Q
P
----------
M
I
A
F
L
E
D
E
L
K
L
S
R
K
---------
H
-------
A
V
L
W
T
A
A
I
V
F
F
S
A
H
L
V
M
F
L
N
K
S
L
D
E
M
D
--
F
W
A
G
T
I
G
V
V
--
F
F
G
L
T
E
L
------
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
R
G
G
I
I
K
V
P
R
I
Y
Y
Y
V
M
R
Y
I
T
P
A
F
L
----------
6
HHSearch
18.12
17%
-12
- C2 -
2WSW
-
?
A:
[87-110]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
E
F
S
T
A
S
W
I
---------------
F
M
M
F
A
S
C
T
S
A
-------
A
-
V
L
F
W
G
-
S
I
E
I
Y
-
Y
Y
I
S
S
P
P
---
F
G
M
E
G
Y
S
A
P
A
K
E
I
G
L
A
Y
S
L
F
H
W
-
G
----
P
L
P
W
A
T
Y
S
-
F
L
S
V
A
F
A
Y
F
F
F
V
R
K
M
-
E
V
I
R
P
S
------
S
T
L
V
P
L
V
G
E
K
H
V
N
G
L
F
G
T
V
V
D
N
F
Y
L
V
A
L
I
L
A
M
G
T
S
L
G
---------------------
L
A
T
P
L
V
T
E
---
C
I
Q
Y
L
F
G
I
P
H
T
L
Q
L
D
A
--
I
I
I
S
C
W
I
L
L
N
A
I
C
V
A
F
G
L
Q
K
G
V
K
------
I
A
S
D
V
R
T
Y
L
S
F
L
M
L
G
W
V
F
I
V
------------
G
G
A
S
F
I
-----------------------------
V
N
Y
F
T
D
S
V
G
T
L
-----
L
M
Y
M
P
R
M
L
F
Y
T
-
D
-
P
I
G
K
G
G
F
P
Q
-------
A
W
T
V
F
Y
W
A
W
----
W
V
I
Y
A
--
I
Q
M
S
I
------------
F
L
A
R
I
S
K
G
R
T
V
-------
R
E
L
C
L
---------
G
M
V
S
G
L
T
-
A
-
G
T
W
L
I
W
T
I
L
G
G
N
T
L
Q
L
I
D
Q
N
I
L
--
N
I
P
Q
L
I
D
Q
Y
G
V
P
R
A
I
I
E
T
W
A
A
L
P
L
--
S
T
A
------
T
M
W
G
F
F
I
L
---
C
F
I
A
T
V
----------
T
L
I
N
A
C
S
Y
T
L
A
M
----------
S
T
C
R
S
M
K
E
G
A
D
P
P
L
---------
L
-------
V
R
I
G
W
S
V
L
V
G
I
I
G
I
I
L
L
A
L
G
G
L
K
P
I
Q
T
--
A
I
I
A
G
G
C
P
L
--
F
F
V
N
I
M
V
------
T
L
S
F
I
K
D
A
K
V
H
W
K
-------------------------------------
14
Fugue
16.82
21%
608
- C4 -
2MBH
-
KLF1_HUMAN
B:
[23-41]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
Q
D
D
F
L
K
W
W
R
S
------
E
E
A
Q
D
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
15.97
14%
562
- C2 -
1TER
1
TERT_APIME
A:
[7-20]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
I
------
P
H
M
C
W
K
K
C
G
K
K
---------------------------------------