@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S39A8_HUMAN: (2015-12-10 )
MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE
Atome Classification :
(20 SA)
------------------.........10........20........30.......--.--40.-.......50........60........70........80.....--...90........100.......110.......120.......130.......140.......150......-.160.......170.......180.......190.......200.......210.......220---.......230.......240.......250.......260.......270.----......280-.......290.......300.......310.......320..--.....330.......340.......350---.......360........370.......380.......390.......400..-------.....410.......420..-----.....430.......440.....---..450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------MAP
G
R
A
V
A
G
L
L
L
L
A
A
AGLGGVAEGPGLA
F
S
E
D
V
L
S
V
FG--A--NLS-L
S
A
A
Q
L
Q
H
L
L
E
QMGAASRVGVPEPGQ
L
H
F
N
QCL
T
A
E
E
I
F
S
LHGF--SNA
T
Q
ITSS
K
F
S
V
I
C
P
A
V
L
Q
QLNFHPCEDRPKHKTRPSHSE
V
W
G
Y
G
F
L
S
V
T
I
I
N
L
A
S
L
L
G
L
I
L
T
P
L
I
KKS
Y
F
-
P
K
I
L
T
F
F
V
G
L
A
I
G
T
L
F
S
N
A
I
F
Q
L
I
P
E
AFGFDP
K
V
D
S
Y
V
E
K
A
V
A
V
F
G
G
F
Y
L
L
F
F
F
E
R
M
L
K
M
L
L
K
T---YGQNGHTHFGNDNFGPQEKTHQPKALPAIN
G
V
T
CYANP
A
V
TEAN
G
H
I
H
FDN----
V
S
V
V
S
LQDG-KKEPSSCTCLKGPKLSE
I
G
T
I
A
W
M
I
T
L
C
D
A
L
H
N
F
I
D
G
LAI
G
A
--
S
C
T
L
S
L
L
Q
G
L
S
T
S
I
A
I
L
C
E
E
F
P
H
E
LG
D
F
---
V
I
L
LNAGM
S
-
T
R
Q
A
L
L
F
N
F
L
S
A
C
S
C
Y
V
G
L
A
F
G
I
L
VGNNFA
P
N
I
I
F
A
LAG
G
M
F
L
-------
Y
I
S
L
A
D
MF
P
E
M
N
D
M
L
R
E
K
VT-----GRKT
D
F
T
F
F
M
IQNAG
M
L
T
G
F
T
A
I
---
L
L
I
T
L
YA
G
E
I
ELE--
32
Fugue
89.33
18%
-77
- C2 -
4NLE
-
?
A:
[18-485]
TIPNVLANRYAS
D
E
M
V
A
I
W
S
P
E
A
K
I
I
A
E
R
R
L
W
L
A
V
L
R
A
Q
A
E
-
L
G
V
A
V
P
D
G
V
V
E
D
Y
E
--
R
--
V
L
E
N
V
D
L
E
S
I
A
A
R
E
R
V
R
H
D
V
K
A
R
I
E
E
F
N
A
H
E
H
V
H
K
G
M
T
S
R
D
L
T
E
N
V
E
Q
--
L
Q
I
R
Q
S
L
E
L
V
F
S
-
H
G
V
A
V
V
A
R
L
A
E
R
A
V
V
Y
R
D
L
V
M
A
G
R
S
H
N
V
A
A
Q
A
T
T
L
G
K
R
F
A
S
A
A
E
E
T
L
V
A
L
T
R
L
--
R
E
L
I
-
D
R
Y
P
L
R
G
V
K
G
P
M
G
T
A
------
Q
D
M
L
D
L
F
G
G
D
V
G
K
L
A
D
L
E
R
R
V
A
E
F
L
G
F
T
E
V
F
--
T
S
V
G
Q
V
Y
P
R
S
---
L
D
H
D
V
L
S
A
L
V
Q
F
G
A
G
P
S
S
M
A
H
T
I
R
L
M
A
G
H
E
L
V
T
E
G
F
A
P
G
Q
V
G
S
S
A
M
P
H
K
M
N
T
R
S
C
E
R
V
N
G
L
Q
V
V
L
R
G
Y
A
S
M
A
A
E
L
A
G
A
Q
W
N
E
-
G
D
V
F
C
S
V
V
R
R
V
A
L
P
D
A
F
F
A
I
D
G
Q
T
--
E
T
F
L
T
V
L
D
E
F
G
A
Y
P
A
V
I
Q
R
E
L
D
R
Y
L
P
F
L
A
T
T
R
I
L
M
A
A
V
R
A
G
V
G
R
E
A
A
H
E
V
I
K
E
H
A
V
A
V
A
L
A
M
R
E
---
Q
G
R
E
P
D
L
I
D
R
L
A
G
D
P
R
L
-------
P
L
D
K
V
A
L
E
A
A
L
E
D
--
K
Q
A
F
T
-----
G
A
A
G
D
Q
V
D
G
V
V
A
A
V
G
E
L
V
S
R
-----------
Y
P
E
A
A
K
Y
T
SG
37
Fugue
63.99
14%
-23
- C1 -
3M6W
-
RSMF_THET8
A:
[4-460]
-------------------
L
P
K
A
F
L
S
R
M
A
E
L
L
G
E
E
F
P
A
F
L
K
A
L
T
E
G
K
R
T
Y
G
L
R
V
N
------
T
L
K
-
L
P
P
E
A
F
Q
R
I
S
P
W
--
P
L
R
P
I
P
W
C
Q
E
G
F
Y
Y
P
E
E
A
R
P
G
P
H
P
F
F
Y
A
G
L
--
Y
Y
I
Q
E
P
S
A
Q
A
V
G
V
L
L
D
P
K
P
G
E
R
V
L
D
L
A
A
A
-
P
G
G
K
T
T
H
L
A
A
R
M
G
G
K
G
L
L
L
A
N
E
V
D
--
G
K
R
V
R
G
L
L
E
N
V
E
R
W
G
A
-
P
L
A
V
T
Q
A
P
P
R
A
L
A
E
A
F
G
T
Y
F
H
R
V
L
L
D
A
P
C
S
G
E
G
M
F
R
K
D
R
E
A
A
R
H
W
G
P
S
A
P
K
R
M
A
E
V
Q
K
A
L
L
A
Q
A
S
R
L
L
G
P
G
G
V
L
V
Y
S
T
C
T
F
A
P
E
E
N
E
G
V
V
A
H
F
L
K
A
-----
H
P
E
F
R
L
E
D
A
R
L
H
P
L
F
A
P
-----
G
V
P
E
W
G
E
G
-
N
P
E
L
L
K
T
A
R
L
W
P
H
R
L
E
G
E
G
H
F
L
A
R
F
R
K
E
G
G
A
W
S
T
P
R
L
E
R
P
S
P
LS
Q
E
A
L
R
A
F
R
G
F
L
E
E
A
G
L
T
L
E
G
P
V
L
D
R
A
G
H
---
L
Y
L
L
P
E
G
L
P
-
T
L
L
G
L
K
A
-------
P
A
P
G
L
Y
L
G
K
V
Q
K
G
R
F
L
P
A
R
A
L
A
L
A
F
G
A
T
L
PWPEG
L
P
R
L
A
L
T
P
E
D
P
R
A
L
A
F
A
T
G
E
G
V
A
W
E
G
E
D
H
P
L
A
L
V
V
L
K
T
A
A
G
E
F
P
L
D
F
G
K
A
K
RG
V
L
R
P
V
G
V
G
L
R
S
H
H
--
17
HHSearch
50.56
13%
-33
- C2 -
2JOJ
-
?
A:
[32-93]
----------------------------------------------
E
I
K
E
A
F
D
L
F
D
TN
K
--
T
G
S
-
I
D
Y
H
E
L
K
V
A
M
R
A
L
G
F
D
V
K
K
P
-------------
E
I
L
E
L
M
N
E
Y
D
R
--
E
G
N
G
Y
I
G
F
D
D
F
L
D
I
M
T
E
K
I
K
N
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
47.82
16%
-17
- C2 -
3J04
-
MLRM_CHICK
B:
[99-163]
--------------------------------------------
E
D
V
I
R
N
A
F
A
C
F
D
EE
A
--
S
G
F
-
I
H
E
D
H
L
R
E
L
L
T
T
M
G
D
R
F
T
D
E
-------------
E
V
D
E
M
Y
R
E
A
P
I
--
D
K
K
G
N
F
N
Y
V
E
F
T
R
I
L
K
H
G
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
47.35
13%
-19
- C2 -
3I5G
-
MLE_TODPA
C:
[85-149]
---------------------------------------------
D
E
F
M
E
A
F
K
T
F
D
--
R
EG
Q
G
L
-
I
S
S
A
E
I
R
N
V
L
K
M
L
G
E
R
I
T
E
D
-------------
Q
C
N
D
I
F
T
F
C
D
I
R
E
D
I
D
G
N
I
K
Y
E
D
L
M
K
K
V
M
A
G
P
F
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
47.22
16%
-17
- C2 -
1M45
1
MLC1_YEAST
A:
[83-145]
---------------------------------------------
E
D
F
V
K
A
F
Q
V
F
D
KE
S
--
T
G
K
-
V
S
V
G
D
L
R
Y
M
L
T
G
L
G
E
K
L
T
D
A
-------------
E
V
D
E
L
L
K
G
V
E
V
--
D
S
N
G
E
I
D
Y
K
K
F
I
E
D
V
L
R
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
47.17
10%
-39
- C2 -
1TIZ
-
CML34_ARATH
A:
[3-64]
-----------------------------------------------
A
K
R
V
F
E
K
F
D
KN
K
--
D
G
K
-
L
S
L
D
E
F
R
E
V
A
L
A
F
S
P
Y
F
T
Q
-------------
E
D
I
V
K
F
F
E
E
I
D
V
--
D
G
N
G
E
L
N
A
D
E
F
T
S
C
I
E
K
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
46.97
11%
-37
- C2 -
1QV0
2
OBL_OBELO
A:
[113-177]
---------------------------------------------
E
W
G
D
A
V
F
D
I
F
D
------
G
T
-
I
T
L
D
E
W
K
A
Y
G
K
I
S
G
I
S
P
S
Q
-----------
E
--
D
C
E
A
T
F
R
H
C
D
L
--
D
N
A
G
D
L
D
V
D
E
M
T
R
Q
H
L
G
F
W
Y
T
L
D
P
E
A
D
G
L
Y
G
N
G
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
46.86
9%
-43
- C2 -
1UHK
1
AEQ2_AEQVI
A:
[111-179]
-----------------------------------------------
G
D
A
L
F
D
I
V
D
KD
Q
--
N
G
A
-
I
T
L
D
E
W
K
A
Y
T
K
A
A
G
I
I
Q
S
S
----------
E
D
---
C
E
E
T
F
R
V
C
D
I
--
D
E
S
G
Q
L
D
V
D
E
M
T
R
Q
H
L
G
F
W
Y
T
M
D
P
A
C
E
K
L
Y
G
G
A
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
46.70
22%
-13
- C2 -
2BL0
-
MLR_PHYPO
B:
[77-138]
----------------------------------------------
E
M
L
D
A
F
R
A
L
D
--
K
EG
N
G
T
-
I
Q
E
A
E
L
R
Q
L
L
L
N
L
G
D
A
L
T
S
-------------
S
E
V
E
E
L
M
K
E
V
S
V
--
S
G
D
G
A
I
N
Y
E
S
F
V
D
M
L
V
T
G
Y
P
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
45.30
17%
-9
- C2 -
2AAO
-
CDPK1_ARATH
A:
[100-159]
----------------------------------------------
H
L
F
A
A
F
T
Y
F
D
KD
G
--
S
G
Y
-
I
T
P
D
E
L
Q
Q
A
C
E
E
-----------------------
E
E
L
M
R
D
V
D
Q
--
D
N
D
G
R
I
D
Y
N
E
F
V
A
M
M
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
44.50
7%
-55
- C2 -
2B1U
-
CALL5_HUMAN
A:
[83-143]
-----------------------------------------------
L
Q
V
A
F
R
A
F
D
--
Q
DG
D
G
H
-
I
T
V
D
E
L
R
R
A
M
A
G
L
G
Q
P
L
P
Q
E
-------------
E
L
D
A
M
I
R
E
A
D
V
--
D
Q
D
G
R
V
N
Y
E
E
F
A
R
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
44.39
34%
-81
- C2 -
3TRC
-
?
A:
[99-153]
---------------------------------------------------------------------------------------------------------------------------------------------
P
A
Y
K
H
R
P
E
L
G
E
E
D
Y
H
G
F
L
G
I
P
I
I
E
Q
G
E
L
L
G
I
L
V
I
Q
Q
L
E
S
H
H
F
A
E
E
E
E
A
F
C
V
T
L
A
I
H
L
A
A
E
I
A
H
A
R
A
K
G
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
42.11
11%
5
- C2 -
1C7V
-
CAVP_BRALA
A:
[87-151]
--------------------------------------------
E
E
E
I
L
R
A
F
K
V
F
D
AN
G
--
D
G
V
-
I
D
F
D
E
F
K
F
I
M
Q
K
V
G
E
E
P
L
T
D
A
------------
E
V
E
E
A
M
K
E
A
D
E
--
D
G
N
G
V
I
D
I
P
E
F
M
D
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
39.44
15%
14
- C2 -
3KEV
-
?
A:
[6-41]
--------------------------------------------
K
K
A
I
L
E
L
F
Q
T
Y
K
--
E
PL
G
N
Y
-
I
G
A
E
G
L
Q
R
L
F
E
D
I
Q
V
D
P
S
D
V
V
T
L
V
L
A
W
K
L
K
A
S
S
T
C
E
F
S
E
K
E
F
V
E
--
G
L
A
N
L
Q
V
D
S
L
E
K
L
K
R
K
L
S
S
L
R
K
E
I
E
D
P
S
K
F
R
A
F
Y
Q
F
V
F
Q
Y
S
K
E
P
S
Q
R
S
L
P
A
E
T
A
M
A
L
W
D
V
L
L
R
G
R
F
S
L
L
D
S
W
-
L
E
F
L
K
N
N
T
H
S
I
S
R
D
T
W
N
L
L
Y
D
F
S
Q
L
K
D
L
S
D
Y
D
A
W
P
V
L
I
D
D
F
V
K
W
L
K
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
38.14
14%
4
- C2 -
3BQ3
1
DCN1_YEAST
A:
[71-106]
------------------------------------------
V
Y
P
K
E
L
T
Q
V
F
E
H
Y
I
--
N
--
N
N
L
-
F
D
I
D
S
L
V
K
F
I
E
E
L
G
Y
N
L
E
D
L
A
T
L
C
L
A
H
L
L
G
Y
K
K
L
E
E
P
L
K
R
E
D
F
L
--
S
T
W
F
M
Q
G
C
S
T
I
S
D
M
Q
E
C
I
K
T
L
D
V
K
L
H
E
D
L
Q
Y
F
T
Q
I
Y
N
Y
A
F
N
L
I
L
D
P
N
R
K
D
I
D
T
D
E
G
I
Q
Y
W
K
L
F
F
Q
P
E
Y
P
V
R
M
-
E
P
D
L
L
E
A
W
F
R
F
L
R
D
E
G
K
T
T
I
S
K
D
T
W
R
M
L
L
L
F
F
K
R
Y
P
T
I
Q
K
I
I
S
D
Y
D
E
T
A
A
W
P
F
I
I
D
E
F
Y
E
C
L
Q
D
---
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
37.39
13%
17
- C2 -
2OPO
-
POLC3_CHEAL
A:
[12-73]
----------------------------------------------
D
R
E
R
I
F
K
R
F
D
--
T
NG
D
G
K
-
I
S
S
S
E
L
G
D
A
L
K
T
L
G
S
V
T
P
--------------
D
E
V
R
R
M
M
A
E
I
D
T
--
D
G
D
G
F
I
S
F
D
E
F
T
D
F
A
R
A
N
R
G
L
V
K
D
V
S
K
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
35.92
14%
-14
- C2 -
1YX7
-
CLSS_HAEMA
A:
[7-81]
---------------------------------------------
A
E
L
E
A
A
F
K
K
L
D
A
N
G
--
D
G
Y
-
V
T
A
L
E
L
Q
T
F
M
V
T
L
D
A
Y
K
A
L
S
K
--
D
K
--
V
K
---
E
A
S
A
K
L
I
K
M
A
D
K
--
N
S
D
G
K
I
S
K
E
E
F
L
N
A
N
A
E
L
L
C
Q
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
34.97
4%
60
- C2 -
3FWB
-
CDC31_YEAST
A:
[60-86]
----------------------------------------------
E
I
L
D
L
I
D
E
Y
D
SE
G
--
R
H
L
-
M
K
Y
D
D
F
Y
I
V
M
G
E
K
I
L
K
R
D
P
L
D
E
I
K
R
A
F
Q
L
F
D
D
D
H
T
G
K
I
S
I
K
N
L
R
--
R
V
A
K
E
L
G
E
T
L
T
D
E
E
L
R
A
M
I
E
E
F
D
L
D
G
D
G
E
I
N
E
N
E
F
I
A
I
C
T
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
30.56
3%
105
- C2 -
3MWU
-
?
A:
[380-410]
--------------------------------------------
E
D
Q
I
D
S
L
M
P
L
L
D
--
M
DG
S
G
S
-
I
E
Y
S
E
F
I
A
S
A
I
D
R
T
I
L
L
S
R
E
R
M
E
R
A
F
K
M
F
D
K
D
G
S
G
K
I
S
T
K
E
L
E
Q
--
V
D
N
N
K
D
G
E
V
D
F
N
E
F
V
E
M
L
Q
N
F
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------