@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S39AE_HUMAN: (2015-12-10 )
MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISAASFLQDLIHRYGEGDSLTLQQLKALLNHLDVGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQENEENEQTEEGRPSAVEVWGYGLLCVTVISLCSLLGASVVPFMKKTFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPLEDYYVSKSAVVFGGFYLFFFTEKILKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNGDLDHMIPQHCSSELDGKAPMVDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAGSHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMVVLTMYSGQIQIG
Atome Classification :
(20 SA)
.........10........20.....--...30........40........50.--.--......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.-......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300........310.......320-------.........330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430...----....440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
L
L
L
L
H
P
A
F
Q
S
C
L
L
L
T
L
L
G
L
WRTT
P
--
E
A
H
A
S
SLGA
P
A
I
S
A
A
S
F
L
Q
D
L
I
H
RYG--E--GDS
L
T
L
Q
Q
L
K
A
L
L
N
H
LDVGVGRG
N
V
T
Q
H
V
QGHR
N
L
S
T
CFSSGDL
F
T
AHNF
S
E
Q
SRI
G
S
S
E
L
Q
E
F
C
P
T
I
L
Q
Q
L
D
S
RACTSENQENEENEQTEEGRPS
A
V
E
V
WG
Y
G
L
L
C
V
T
V
I
S
L
C
S
L
L
G
A
S
V
V
P
F
M
K
K
T
F
Y
K
R
L
L
L
Y
F
I
A
L
-
A
I
G
T
L
Y
S
N
A
L
F
Q
L
I
P
E
A
FGFN
P
L
E
D
YYVSK
S
A
V
V
FG
G
F
Y
L
F
F
F
T
E
K
I
L
K
I
L
L
K
QKNEHHHGHSHYASESLPSKK
D
Q
E
E
G
V
M
E
K
L
QNGDL
D
H
M
I
P
Q
H
C
SSELDGKAPMV-DE
K
V
I
V
G
S
L
S
V
Q
D
L
Q
ASQS---------
A
C
Y
W
LKGVRYSDI
G
T
L
A
W
M
I
T
L
S
D
G
L
H
N
F
I
D
G
L
AIG
A
S
F
T
V
S
V
F
QGI
S
T
S
V
A
I
L
C
E
E
F
P
H
E
LG
D
F
V
I
L
LNAG
M
S
I
Q
Q
A
L
F
F
N
F
L
S
A
C
C
C
Y
L
G
L
A
F
G
I
LAGSHFSA
N
W
I
F
A
LAG
G
M
----
F
L
Y
I
S
L
A
D
MF
P
E
M
N
E
V
C
Q
E
D
ERKG
S
I
L
I
P
F
I
I
Q
N
L
G
L
L
T
G
F
T
I
M
V
V
L
T
MYS
G
Q
I
QIG
39
Fugue
84.59
15%
-77
- C1 -
4CVH
1
ISPD_HUMAN
A:
[1-411]
----
S
M
H
P
Q
A
V
A
A
V
L
P
A
G
P
T
P
K
Q
F
C
P
IL
E
R
P
L
I
S
Y
T
L
Q
A
L
E
R
V
C
W
I
K
D
I
V
V
A
V
T
--
G
--
E
N
M
E
V
M
K
S
I
I
Q
K
Y
Q
H
K
R
I
S
L
V
E
A
G
V
T
R
H
R
S
I
F
N
G
L
K
A
L
A
---------------------------------------------
E
D
Q
I
N
S
K
L
S
K
P
E
V
V
I
I
H
D
-----------------
A
V
R
P
F
V
E
E
G
V
L
L
K
V
V
T
A
A
K
E
H
G
A
A
G
A
I
R
P
L
V
S
T
V
V
S
P
S
A
D
G
---
C
L
D
Y
S
L
E
R
A
R
H
R
A
S
E
M
P
Q
A
F
L
F
D
V
I
Y
E
-
A
Y
Q
Q
C
S
D
Y
D
L
E
F
G
T
E
C
L
Q
L
A
L
K
Y
C
C
T
K
A
----
K
L
V
E
G
S
P
D
L
W
K
V
T
Y
K
R
D
L
Y
A
A
E
S
I
I
K
-
E
R
I
S
Q
E
I
C
V
V
M
D
T
E
E
D
N
K
H
---------
V
G
H
L
L
E
E
V
L
K
S
E
L
N
H
V
K
V
T
S
E
A
L
D
Q
C
Y
N
F
V
C
V
N
V
T
T
S
D
F
--------------------
Q
E
T
Q
K
L
L
S
M
L
E
E
S
---
S
L
C
I
L
Y
P
V
V
V
V
S
V
H
F
L
D
F
K
L
V
P
P
S
Q
K
M
E
N
L
M
Q
I
R
E
F
A
K
E
V
K
ERN
I
L
L
Y
G
L
L
I
S
Y
P
Q
D
D
Q
K
L
Q
E
S
L
R
Q
G
A
I
I
I
A
S
L
I
K
E
R
N
-----------
S
G
L
I
G
Q
L
L
I
A
4
HHSearch
54.06
13%
-24
- C2 -
1UHK
1
AEQ2_AEQVI
A:
[110-179]
--------------------------------------------
W
G
D
A
L
F
D
I
V
D
KD
Q
--
N
G
A
I
T
L
D
E
W
K
A
Y
T
K
A
A
G
I
I
Q
S
S
-------------
E
---
D
C
E
E
T
F
R
V
C
D
I
D
E
S
G
Q
L
D
V
D
E
M
T
R
Q
H
L
G
F
W
Y
T
M
D
P
A
C
E
K
L
Y
G
G
A
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
51.58
13%
-50
- C2 -
2JOJ
-
?
A:
[32-93]
--------------------------------------------
E
I
K
E
A
F
D
L
F
D
TN
K
--
T
G
S
I
D
Y
H
E
L
K
V
A
M
R
A
L
G
F
D
V
K
K
P
----------------
E
I
L
E
L
M
N
E
Y
D
R
E
G
N
G
Y
I
G
F
D
D
F
L
D
I
M
T
E
K
I
K
N
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
47.01
21%
-75
- C2 -
1WNF
2
?
A:
[6-124]
------------------------------------------------------------------------------
L
G
M
G
G
T
I
A
S
V
K
G
E
R
G
Y
E
S
A
L
S
V
S
K
I
L
K
L
A
G
I
S
--
A
K
I
E
A
R
D
L
M
N
V
D
S
T
L
I
Q
P
S
D
W
E
R
L
A
K
E
I
E
K
---------------
E
V
W
E
Y
D
G
I
V
I
T
H
G
T
D
T
M
A
Y
S
A
S
M
L
S
F
M
L
R
N
P
P
I
P
I
V
L
T
G
S
M
L
-
P
I
T
E
K
N
S
D
A
P
F
N
L
R
T
A
L
E
F
V
K
L
G
I
R
G
I
Y
I
A
F
N
G
K
V
M
L
G
V
R
A
S
K
I
R
S
M
G
F
D
A
F
E
S
I
N
Y
P
N
V
A
E
I
K
D
D
K
L
R
I
L
H
I
P
D
F
Y
G
D
E
F
F
S
D
I
K
Y
E
P
K
V
L
V
I
K
L
I
P
G
L
S
G
D
I
V
R
E
A
-
L
R
L
G
Y
K
G
I
I
L
E
G
Y
G
V
G
G
I
P
---------
Y
R
G
T
D
L
F
E
V
V
S
S
I
S
K
R
I
P
V
V
L
T
T
Q
A
I
Y
D
G
V
D
L
Q
R
Y
K
V
G
R
I
A
L
E
A
G
V
I
P
A
G
D
M
T
K
E
A
T
I
T
K
L
M
W
I
L
G
H
T
K
N
I
E
E
V
K
Q
L
M
G
K
N
I
T
G
E
L
T
R
----------------------------------------------------------------------------------------
2
PsiBlast_PDB
46.85
26%
-7
- C2 -
3K6E
-
?
A:
[50-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
P
V
V
T
D
-
K
Q
F
V
G
T
I
G
L
R
D
I
M
A
Y
Q
M
E
H
DLS
Q
E
I
M
A
D
T
D
I
V
H
M
T
K
T
D
V
A
V
V
S
P
D
F
T
I
T
E
V
L
H
K
L
V
D
E
S
F
L
P
V
V
D
A
E
G
I
F
Q
G
I
I
T
R
K
S
I
L
K
A
V
N
A
L
L
H
D
-----------------------------------------------------------------------------------------------------------------
21
HHSearch
45.88
10%
-18
- C2 -
1QV0
2
OBL_OBELO
A:
[112-176]
------------------------------------------
R
E
W
G
D
A
V
F
D
I
F
D
------
G
T
I
T
L
D
E
W
K
A
Y
G
K
I
S
G
I
S
P
S
Q
--------------
E
--
D
C
E
A
T
F
R
H
C
D
L
D
N
A
G
D
L
D
V
D
E
M
T
R
Q
H
L
G
F
W
Y
T
L
D
P
E
A
D
G
L
Y
G
N
G
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
42.79
7%
-17
- C2 -
1TIZ
-
CML34_ARATH
A:
[3-63]
---------------------------------------------
A
K
R
V
F
E
K
F
D
KN
K
--
D
G
K
L
S
L
D
E
F
R
E
V
A
L
A
F
S
P
Y
F
T
Q
----------------
E
D
I
V
K
F
F
E
E
I
D
V
D
G
N
G
E
L
N
A
D
E
F
T
S
C
I
E
K
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
42.55
10%
-10
- C2 -
1M45
1
MLC1_YEAST
A:
[81-145]
-----------------------------------------
K
T
E
D
F
V
K
A
F
Q
V
F
D
KE
S
--
T
G
K
V
S
V
G
D
L
R
Y
M
L
T
G
L
G
E
K
L
T
D
----------------
A
E
V
D
E
L
L
K
G
V
E
V
D
S
N
G
E
I
D
Y
K
K
F
I
E
D
V
L
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
41.99
22%
107
- C2 -
2Q6Q
-
SPC42_YEAST
A:
[3-64]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
N
K
E
L
N
F
K
L
R
E
K
Q
N
E
I
F
E
L
K
K
I
A
-
E
T
L
R
S
K
L
E
K
Y
V
D
I
T
K
K
L
E
D
Q
N
L
N
L
Q
I
K
I
S
D
L
E
K
K
L
S
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
41.69
8%
-19
- C2 -
3FIA
-
ITSN1_HUMAN
A:
[30-92]
----------------------------------------
E
E
R
A
K
H
D
Q
Q
F
H
S
L
K
P-
I
--
S
G
F
I
T
G
D
Q
A
R
N
F
F
F
Q
S
G
L
P
Q
P
------------------
V
L
A
Q
I
W
A
L
A
D
M
N
N
D
G
R
M
D
Q
V
E
F
S
I
A
M
K
L
I
K
L
K
L
Q
G
Y
Q
L
P
S
A
L
P
P
V
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
40.31
15%
32
- C2 -
1YX7
-
CLSS_HAEMA
A:
[7-81]
-------------------------------------------
A
E
L
E
A
A
F
K
K
L
D
A
N
G
--
D
G
Y
V
T
A
L
E
L
Q
T
F
M
V
T
L
D
A
Y
K
A
L
S
K
---
D
K
----
V
K
---
E
A
S
A
K
L
I
K
M
A
D
K
N
S
D
G
K
I
S
K
E
E
F
L
N
A
N
A
E
L
L
C
Q
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
38.74
17%
73
- C2 -
3FWB
-
CDC31_YEAST
A:
[60-85]
--------------------------------------------
E
I
L
D
L
I
D
E
Y
D
SE
G
--
R
H
L
M
K
Y
D
D
F
Y
I
V
M
G
E
K
I
L
K
R
D
P
L
D
E
I
K
R
A
F
Q
L
F
D
D
D
H
T
G
K
I
S
I
K
N
L
R
R
V
A
K
E
L
G
E
T
L
T
D
E
E
L
R
A
M
I
E
E
F
D
L
D
G
D
G
E
I
N
E
N
E
F
I
A
I
C
T
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
38.45
26%
0
- C2 -
4PC4
3
?
A:
[10-68]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Q
D
L
E
E
K
L
Y
N
S
I
L
T
G
D
Y
D
S
A
V
R
Q
S
L
E
Y
E
S
Q
G
K
G
S
I
I
-
Q
N
--
V
V
N
N
L
I
I
D
K
R
R
N
T
M
E
---------
Y
C
Y
K
L
W
V
G
N
G
Q
E
I
V
R
K
Y
F
P
L
N
F
R
L
I
M
A
G
N
Y
V
K
I
I
Y
R
N
Y
N
L
A
L
K
L
G
S
T
T
N
P
S
N
E
R
I
A
Y
G
D
G
V
D
K
H
T
E
L
V
S
W
K
F
I
T
L
W
E
N
N
R
V
Y
F
K
I
H
N
T
K
Y
N
Q
Y
L
K
M
S
T
T
T
C
N
C
N
S
R
D
R
V
V
Y
G
G
N
S
----
A
D
S
T
R
E
Q
W
F
F
Q
P
A
K
Y
E
N
D
V
L
F
F
I
Y
N
R
Q
F
N
D
A
L
E
L
G
T
I
V
N
A
S
G
D
R
K
A
V
G
H
D
G
E
V
A
G
L
P
18
HHSearch
37.13
18%
82
- C2 -
2B1U
-
CALL5_HUMAN
A:
[83-112]
---------------------------------------------
L
Q
V
A
F
R
A
F
D
--
Q
DG
D
G
H
I
T
V
D
E
L
R
R
A
M
A
G
L
G
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
35.56
6%
-16
- C2 -
3J04
-
MLRM_CHICK
B:
[99-163]
------------------------------------------
E
D
V
I
R
N
A
F
A
C
F
D
EE
A
--
S
G
F
I
H
E
D
H
L
R
E
L
L
T
T
M
G
D
R
F
T
D
----------------
E
E
V
D
E
M
Y
R
E
A
P
I
D
K
K
G
N
F
N
Y
V
E
F
T
R
I
L
K
H
G
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
35.04
5%
31
- C2 -
1C7V
-
CAVP_BRALA
A:
[87-151]
------------------------------------------
E
E
E
I
L
R
A
F
K
V
F
D
AN
G
--
D
G
V
I
D
F
D
E
F
K
F
I
M
Q
K
V
G
E
E
P
L
T
D
-------------
A
--
E
V
E
E
A
M
K
E
A
D
E
D
G
N
G
V
I
D
I
P
E
F
M
D
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
33.57
11%
-12
- C2 -
3BQ3
-
DCN1_YEAST
A:
[70-105]
---------------------------------------
P
V
Y
P
K
E
L
T
Q
V
F
E
H
Y
I
--
N
--
N
N
L
F
D
I
D
S
L
V
K
F
I
E
E
L
G
Y
N
L
E
D
L
A
T
L
C
L
A
H
L
L
G
Y
K
K
L
E
E
P
L
K
R
E
D
F
L
S
T
W
F
M
Q
G
C
S
T
I
S
D
M
Q
E
C
I
K
T
L
D
V
K
L
H
E
D
L
Q
Y
F
T
Q
I
Y
N
Y
A
F
N
L
I
L
D
P
N
R
K
D
I
D
T
D
E
G
I
Q
Y
W
K
L
F
F
Q
P
E
Y
P
V
R
M
E
P
D
L
L
E
A
W
F
R
F
L
R
D
E
G
K
T
T
I
S
-
K
D
T
W
R
M
L
L
L
F
F
K
R
Y
P
T
I
Q
K
I
I
S
D
Y
D
E
T
A
A
W
P
F
I
I
D
E
F
Y
E
C
L
Q
D
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
33.39
21%
10
- C2 -
3KEV
-
?
A:
[6-40]
------------------------------------------
K
K
A
I
L
E
L
F
Q
T
Y
K
--
E
PL
G
N
Y
I
G
A
E
G
L
Q
R
L
F
E
D
I
Q
V
D
P
S
D
V
V
T
L
V
L
A
W
K
L
K
A
S
S
T
C
E
F
S
E
K
E
F
V
E
G
L
A
N
L
Q
V
D
S
L
E
K
L
K
R
K
L
S
S
L
R
K
E
I
E
D
P
S
K
F
R
A
F
Y
Q
F
V
F
Q
Y
S
K
E
P
S
Q
R
S
L
P
A
E
T
A
M
A
L
W
D
V
L
L
R
G
R
F
S
L
L
D
S
W
L
E
F
L
K
N
N
T
H
S
I
S
R
D
T
W
N
L
L
Y
D
-
F
S
Q
L
K
D
L
S
D
Y
D
A
W
P
V
L
I
D
D
F
V
K
W
L
K
H
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
31.86
7%
85
- C2 -
3I5G
-
MLE_TODPA
C:
[85-115]
-------------------------------------------
D
E
F
M
E
A
F
K
T
F
D
--
R
EG
Q
G
L
I
S
S
A
E
I
R
N
V
L
K
M
L
G
E
R
I
T
E
D
Q
C
N
D
I
F
T
F
C
D
I
R
E
D
I
D
G
N
I
K
Y
E
D
L
M
K
K
V
M
A
G
P
F
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
30.55
11%
106
- C2 -
2PVB
1
PRVB_ESOLU
A:
[41-105]
-----------------------------------------
S
L
D
D
V
K
K
A
F
Y
V
I
D
--
Q
DK
S
G
F
I
E
E
D
E
L
K
L
F
L
Q
N
F
S
P
S
A
R
A
L
-------------
T
D
A
E
T
K
A
F
L
A
D
G
D
K
D
G
D
G
M
I
G
V
D
E
F
A
A
M
I
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------