@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S45A2_HUMAN: (2015-12-11 )
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKERQQAPGGDPDNSVRGKGMDCATLTCMVQLAQILVGGGLGFLVNTAGTVVVVVITASAVALIGCCFVALFVRYVD
Atome Classification :
(20 SA)
.........10........20........30........40.......----.50........60..-.......70........80........90........100.....--..110.......120.......130.......140.......150..----.....160.......170.....-..180........190.......200...----------..------.--.210.......220.......230..-.....240.......250.......260.......270.......280.......290.......300......-..310.......320.......330.......340.....--..350.......360.......370.......380.......390.......400.-...---...410....-..---.----420.......430.......440.......450.......460.......470......-.480.....-..490.......500.......510.......520.......530-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGSNSG
Q
A
G
R
H
I
Y
K
S
L
ADDGPFDSVEPPKR
P
T
S
R
L
I
M
H
S
M
A
M
F
G
R
E
F
C
----
Y
A
V
E
A
A
Y
V
T
P
V
L
-
L
S-VGL
P
S
S
L
Y
S
I
V
W
F
L
S
P
I
L
G
F
L
L
Q
P
VVGS
A
S
D
H
C
R
S
RWGRRR
P
Y
I
L
--
T
L
G
V
M
M
L
V
G
M
A
L
YLN
G
A
T
V
V
A
A
L
IANPR
R
K
L
V
W
A
I
S
V
T
M
I
G
V
V
L
F
D
F
----
A
A
D
FIDG
P
I
K
A
Y
L
F
D
V
CSH
Q
D
K
E-KG
L
H
-
Y
H
A
L
F
TG
F
G
G
A
L
G
Y
L
L
G
A
I
D
W
A
H
L
----------
E
L
------
G
--
R
L
LGT
E
F
Q
V
M
F
F
F
S
A
L
V
L
T
L
C
F
T
V
H
L-CSISEA
P
L
T
E
V
AKGIPPQQTPQDPPLSSDGMYEYG
S
I
E
K
V
KNGYV
N
P
E
L
A
MQGAKNK
N
H
A
E
Q
T
R
R
A
-
M
T
L
K
S
L
L
-
R
A
L
VNMPP
H
Y
R
Y
L
C
I
S
H
L
I
G
W
T
A
F
L
S
N
M
L
F
F
T
D
F
M
G
Q
I
V
Y--RGDPYSAHNS
T
E
F
L
I
Y
ERGVEV
G
C
W
G
L
C
I
N
S
V
F
S
S
L
Y
S
Y
F
Q
K
V
L
V
S
Y
IGL
K
G
L
Y
F
T
-
G
Y
L
---
L
F
GLG
T
G
F
I
G
-L
F
---
P
----
N
V
Y
S
T
L
V
L
C
S
L
F
G
V
M
S
S
T
L
Y
T
V
P
F
N
L
I
T
E
Y
H
R
E
E
E
K
E
R
QQAPGGDPDNSVRGKGM
D
C
A
T
-
L
T
C
M
V
Q
L
A
Q
-
I
L
VGGG
L
G
F
L
V
NTA
G
T
V
V
V
V
V
I
T
A
S
A
V
A
L
I
G
C
C
F
V
A
L
F
V
R
YVD---
7
HHSearch
92.60
15%
-121
- C2 -
2CFQ
-
LACY_ECOLI
A:
[6-392]
-------------------------------
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
----
M
G
A
Y
F
P
F
F
P
I
W
L
-
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
----
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
P
L
L
---------------
Q
Y
N
I
L
V
G
S
I
V
G
G
I
YLGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
-
R
-
R
S
N
-
F
E
F
G
-
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
--
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
-------------------------------------------
N
H
S
A
-
F
S
L
K
L
-
A
-
L
E
L
F
R
Q
-
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
----------------
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
-
A
G
T
---
I
M
S
V
R
I
I
G
S
S
-
F
A
---
T
----
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
-----------------
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
---
20
Fugue
85.25
13%
-115
- C2 -
1PV6
-
LACY_ECOLI
A:
[1-417]
M
----------------------
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
----
F
P
F
F
P
I
W
L
H
D
I
N
-----
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
-----
L
R
K
Y
L
L
--
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
P
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
----
V
E
A
F
I
E
K
V
S
R
R
S
----------
N
-
F
E
F
G
-
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
I
---------------------------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
-
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
-----------------------------
L
K
L
A
L
E
L
F
R
Q
P
K
L
-
W
F
L
S
L
Y
V
-
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
--
L
L
N
A
S
I
M
F
F
-------------------------------
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
-
A
G
T
---
I
M
S
V
R
I
I
G
S
S
-
F
A
---
T
----
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
-------
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
-
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
4
HHSearch
77.47
11%
-126
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[32-425]
--------------------------------------
C
S
L
F
F
L
W
A
V
A
----
N
N
L
N
D
I
L
L
P
Q
F
Q
-
Q
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
----
L
S
Y
K
A
-
G
I
I
--
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
-------------
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
----
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
-
E
S
S
G
H
F
R
L
N
-
L
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
VPHQS
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
---
N
H
S
D
A
-----------------------------------------------
K
Q
-
G
S
F
S
A
S
L
-
S
R
L
A
R
I
-
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
--
G
M
T
A
G
----------------
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
-
Y
A
L
---
I
A
M
A
L
C
L
I
S
A
-
F
A
---
G
----
G
H
V
-
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
------------------
K
Y
G
S
S
F
-
I
-
V
M
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----
5
HHSearch
75.37
13%
-124
- C2 -
3WDO
-
?
A:
[11-379]
---------------------------------
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
----
M
F
M
V
L
P
V
L
T
T
Y
G
-
M
A
L
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
----
I
G
R
K
P
-
L
I
V
--
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
S
D
S
I
----------------
W
G
I
I
L
G
R
A
L
Q
G
S
----
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
-
K
A
M
A
-
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
--------------------------
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
-
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
-----------------------------------------------
G
M
V
K
-
G
S
F
S
K
-----
V
L
A
E
-
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
----
G
F
P
A
A
E
-------------
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
--
F
V
F
-
C
V
G
---
L
I
V
V
A
E
I
V
L
W
N
A
Q
---
T
----
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
-----------------
K
G
T
A
M
G
V
-
Y
S
T
S
Q
F
L
G
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
-
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
---
3
HHSearch
71.59
11%
-131
- C2 -
1PW4
-
GLPT_ECOLI
A:
[49-428]
--------------------------------------------------------
A
L
A
M
P
-
Y
L
-
V
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
----
S
N
P
R
V
-
F
L
P
--
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
V
P
W
A
------------
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
-
G
I
V
S
-
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W
-------------------------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
-
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
-----------------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
-
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
---
H
F
A
L
D
K
----------------
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
-
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
-
M
N
PA-
G
----
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
-----------------
A
G
T
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
---
6
HHSearch
68.48
12%
-114
- C2 -
2GFP
-
EMRD_ECOLI
A:
[18-360]
------------------------------------------
A
V
G
Q
M
A
----
Q
T
I
Y
I
P
A
I
A
D
M
A
-
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
----
V
G
R
R
P
-
V
I
L
--
V
G
M
S
I
F
M
L
A
T
L
V
A
V
T
T
S
S
L
----------------
T
V
L
I
A
A
S
A
M
Q
G
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
-
H
A
N
S
-
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
M
--------------------------
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
-
R
W
M
P
E
T
R
P
V
D
A
P
R
-------------------------------------------------
T
R
L
L
-
T
S
Y
K
T
L
-----
F
G
N
-
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-
L
--
G
L
S
S
M
----------------
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
---
L
A
G
L
L
M
W
I
P
D
-
W
F
G
V
-
M
----
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
-----------------
A
G
T
A
G
A
L
-
V
G
G
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
----------
8
HHSearch
51.03
15%
-99
- C2 -
3WDO
-
?
A:
[48-178]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
-
G
L
A
---
V
F
A
A
G
S
V
I
A
A
-
L
S
---
D
----
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
-----------------
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
---
9
HHSearch
42.53
14%
-100
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[63-177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
-
G
L
F
---
L
Y
A
L
G
A
A
L
F
W
-
P
A
A
E
I
M
----
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
-----------------
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
---
21
Fugue
40.76
20%
107
- C2 -
1UMQ
-
A:
[22-81]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
G
E
S
L
P
P
P
P
E
N
P
M
S
A
D
R
V
R
W
E
H
I
Q
R
I
Y
E
M
-----------
C
D
R
N
V
S
E
T
A
R
R
L
N
M
H
R
R
T
L
Q
-
R
I
L
A
K
R
S
P
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
37.93
11%
-84
- C2 -
1PW4
-
GLPT_ECOLI
A:
[65-199]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
-
G
L
I
---
L
A
A
A
V
M
L
F
M
G
-
F
V
---
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
-----------------
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
---
12
HHSearch
37.89
13%
-118
- C2 -
2CFQ
-
LACY_ECOLI
A:
[257-396]
-----------------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
----
I
G
G
K
N
-
A
L
L
--
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
----------------
L
E
V
V
I
L
K
T
L
H
M
F
----
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
-
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
--------------------------
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
-
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
37.19
10%
-73
- C2 -
2GFP
-
EMRD_ECOLI
A:
[45-169]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
-
G
M
S
---
I
F
M
L
A
T
L
V
A
V
-
T
T
---
S
----
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
-----------------
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
---
2
PsiBlast_PDB
35.06
29%
-80
- C2 -
4B8B
-
NOT1_YEAST
A:
[174-229]
------------------------------------------------------------------------------------------------------------------------------
L
N
A
E
G
T
R
K
V
S
E
T
I
P
N
T
K
Q
S
L
L
Y
L
L
S
I
A
S
L
N
L
E
L
F
L
Q
----
R
E
E
L
S
D
G
P
M
L
A
Y
-
F
Q
E
C
F
F
E
D
F
N
-
Y
A
P
E
-
Y
L
I
L
A
L
V
K
E
M
K
R
F
V
L
L
I
E
N
R
T
V
I
D
----------
E
I
------
L
--
I
T
L
L
I
Q
V
H
N
K
S
P
S
S
F
K
D
V
I
S
T
I
T
D
D
S
-
K
I
V
D
A
A
K
I
I
I
N
S
D
D
A
P
I
A
N
F
L
K
S
L
L
D
T
G
R
L
D
T
V
I
N
K
L
P
F
N
E
A
F
K
I
L
P
C
A
R
Q
I
G
W
E
G
F
D
T
F
L
K
T
K
V
S
-
P
S
N
V
D
V
V
-
L
E
S
L
E
V
Q
T
K
M
T
D
T
P
F
R
S
L
K
T
F
D
L
F
A
F
H
S
L
I
E
V
L
N
K
C
P
L
D
V
--
L
Q
L
Q
R
F
E
S
L
E
F
S
L
L
I
A
F
P
R
L
I
N
F
G
F
G
H
D
E
A
I
L
A
N
G
D
I
A
G
I
N
N
D
I
E
K
E
M
Q
N
Y
L
Q
K
M
Y
-
S
G
E
---
L
A
I
K
D
V
I
E
L
L
-
R
R
---
L
----
R
D
S
D
L
P
R
D
Q
E
V
F
T
C
I
T
H
A
V
I
A
E
S
T
F
F
Q
D
Y
P
L
D
A
L
A
T
T
S
V
L
F
G
S
M
I
L
F
Q
L
L
R
G
F
V
L
D
V
A
F
-
R
I
I
M
R
F
A
K
E
-
P
P
E
S
K
M
F
K
F
A
V
Q
A
I
Y
A
F
R
I
R
L
A
E
Y
P
Q
Y
C
K
D
L
L
R
D
V
P
A
L
K
S
Q
A
Q
---
22
Fugue
34.94
16%
197
- C2 -
2W0C
-
P3_BPPM2
P:
[1-65]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
T
S
V
P
T
S
V
P
T
N
Q
S
V
W
G
N
V
S
T
G
L
D
A
L
I
S
G
W
A
R
V
E
-
Q
I
K
A
A
K
A
S
T
G
Q
G
R
V
E
Q
A
-
M
T
P
E
L
D
N
-
G
A
A
V
V
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
34.28
19%
328
- C2 -
1VTP
-
?
A:
[1-26]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
A
S
K
V
D
E
Y
V
G
E
V
E
N
D
L
Q
K
S
K
V
A
V
S
----------------------------------------------------------------------
16
Fugue
34.28
19%
328
- C2 -
1VTP
-
?
?:
[1-26]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
A
S
K
V
D
E
Y
V
G
E
V
E
N
D
L
Q
K
S
K
V
A
V
S
----------------------------------------------------------------------
19
Fugue
29.19
20%
381
* C2 *
2DOH
-
C:
[4-28]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
A
E
L
Q
R
L
K
N
E
R
H
E
E
A
E
L
E
R
-
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
28.02
14%
318
- C2 -
4PVZ
-
?
C:
[3-37]
L
G
S
T
N
K
R
K
R
E
Q
I
S
T
D
N
E
A
K
M
Q
I
Q
E
E
K
S
P
K
K
K
R
K
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
27.82
36%
362
- C2 -
1LBJ
-
A:
[1-22]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
P
I
F
T
Y
G
E
L
Q
R
M
Q
E
K
E
R
N
K
G
Q
--------------------------------------------------------------------------
1
PsiBlast_PDB
27.69
34%
-91
- C1 -
4M64
-
MELB_SALTY
A:
[16-81]
------------------------------------------
F
G
K
D
F
A
I
G
I
V
Y
M
Y
L
M
Y
Y
Y
T
D
V
V
G
L
S
-
V
G
L
V
G
T
L
F
----
L
V
A
R
I
W
D
A
I
N
D
P
I
M
G
W
I
V
N
A
T
R
S
R
W
G
K
F
K
P
W
I
L
--
I
G
T
L
T
N
S
L
V
L
F
L
L
F
S
A
H
L
F
E
G
T
A
Q
V
V
F
V
C
V
T
Y
I
L
W
G
M
T
Y
T
I
M
D
I
P
F
W
----
S
L
V
P
T
I
T
L
D
K
R
E
R
E
Q
L
V
P
F
P
R
F
F
-
A
S
L
A
-
G
F
V
T
A
G
I
T
L
P
F
V
S
Y
V
G
G
A
D
R
G
F
G
F
----------
Q
M
------
F
--
T
L
V
L
I
A
F
F
I
A
S
T
I
V
T
L
R
N
V
H
E
V
Y
S
S
D
-
N
G
V
T
A
G
R
P
H
L
T
L
K
T
I
V
G
L
I
Y
K
N
D
Q
L
S
C
L
L
G
M
A
L
A
Y
N
I
A
S
N
I
I
N
G
F
A
I
Y
Y
F
T
Y
V
I
G
D
A
D
L
F
P
Y
Y
L
S
Y
-
A
G
A
A
N
L
L
-
T
L
I
V
F
P
R
L
V
K
M
L
S
R
R
I
L
W
A
G
A
S
V
M
P
V
L
S
C
A
G
L
F
A
M
A
L
A
D
I
--
H
N
A
A
L
I
V
A
A
G
I
F
L
N
I
G
T
A
L
F
W
V
L
Q
V
I
M
V
A
D
T
V
D
Y
G
E
F
K
L
N
I
R
C
E
S
I
A
Y
S
V
Q
T
M
V
V
K
-
G
G
S
---
A
F
A
A
F
F
I
A
L
V
-
L
G
---
L
----
I
G
Y
T
P
N
V
A
Q
S
A
Q
T
L
Q
G
M
Q
F
I
M
I
V
L
P
V
L
F
F
M
M
T
L
V
L
Y
F
R
Y
Y
R
L
N
G
D
M
L
R
K
I
Q
I
H
L
L
-------------------------------------------------------------