@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S4A11_HUMAN: (2015-12-11 )
MSQVGGRGDRCTQEVQGLVHGAGDLSASLAENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDEAFDTANSSIVSGESIRFFVNVNLEMQATNTENEATSGGCVLLHTSRKYLKLKNFKEEIRAHRDLDGFLAQASIVLNETATSLDNVLRTMLRRFARDPDNNEPNCNLDLLMAMLFTDAGAPMRGKVHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFLASPTELPSATHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSHGFREIEMSKFRYNPSESPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRIIEAKYLDVMDAEHRP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60--........70........80........90........100.......110.......120.......130-.......140........150.......160.......170.......180-.......190....-..---.200.-----------------------.-----------......210.......220---.-......230.......240-.-.-----.-....250.......260....-...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420..-.....430.......440.......450.......460.......470.....----..480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640------.......650-......-..660.....-..670.......680.......690........700.......710.......720.......730.......740.......750.......760.......770-........780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQVGGRG
D
R
C
T
Q
E
V
Q
G
L
VHGAGD
L
S
A
S
LAENSPTMSQNGYFEDS
S
Y
Y
KCDTDD
T
F
E
A
R
E
E
--
I
LGDEAFDTANSSIVSG
E
S
I
R
F
F
V
N
V
N
L
E
M
Q
ATNTENEATSG
G
C
V
L
L
HTS
R
K
Y
L
K
L
K
N
F
K
E
E
I
R
AHR
D
L
D
G
-
F
L
A
Q
A
S
I
V-LN
E
T
A
T
S
L
D
N
V
L
R
T
M
L
R
R
FARDPDNNEPNC
N
L
D
L
L
M
A
M
L
FTD-AGAPMR
G
K
V
H
L
L
S
D
-TI---QG-
V
T
-----------------------
A
-----------
T
V
T
G
V
R
Y
QQ
S
W
L
C
I
I
C
T
M
K
---
A
-
L
Q
K
R
H
V
C
I
S
R
L
VRPQNWGE-N-S-----
C
-
E
V
R
F
V
I
L
V
LAPPKMK
S
T
K
T
A
M
-
E
V
A
R
T
F
A
T
M
F
S
D
I
A
F
R
Q
K
L
L
E
TR
T
E
E
E
F
K
E
A
L
V
H
Q
R
Q
L
L
T
M
VSHGPVAPRTKER
S
T
VSLPAHRHPEPPKCKDFVPF
G
K
G
I
R
E
D
I
A
R
RFPLYPLDFTDGIIGKNKAV
G
K
Y
I
T
T
T
L
F
L
Y
F
A
C
L
L
P
T
I
AFGSLNDENTDG
A
I
D
V
Q
K
T
IAGQ
S
I
G
G
L
L
Y
A
L
F-SGQ
P
L
V
I
L
L
TT
A
P
L
A
L
Y
I
Q
V
I
R
V
I
CDDYDLDFN
S
F
Y
A
W
T
G
L
W
N
S
F
F
L
A
L
Y
A
F
F
----
N
L
S
L
V
M
S
L
F
K
R
S
T
E
E
I
I
A
L
F
I
S
I
T
F
V
L
D
A
VKG
T
V
K
I
F
W
K
Y
Y
Y
G
H
Y
L
D
D
YHTKRTS
S
L
V
S
LSGLGASL
N
A
S
L
H
T
A
L
N
A
S
FLASPTELPSATHSG
Q
A
T
A
V
L
S
L
L
I
M
L
G
T
L
W
L
G
Y
T
L
Y
Q
FKKSPY
L
H
P
C
V
R
E
I
L
S
DCA
L
P
I
A
V
L
A
F
S
L
I
S
SHG
F
R
EI
E
M
S
K
F
RYNPSE------SP
F
A
M
A
Q
I
Q
--
S
L
S
L
R
A-VSGA
M
G
L
G
F
L
-
L
S
M
L
F
F
I
E
Q
N
L
V
A
A
L
VNAPEN
R
L
-
V
KGTA
Y
H
W
D
L
L
L
L
A
I
I
N
T
G
L
S
L
FGL
P
W
I
HAAYPHSP
L
H
V
R
A
L
A
L
V
E
E
R
VENG
H
I
Y
D
T
I
V
N
V
K
E
T
R
L
T
S
L
G
A
S
V
L
V
G
L
S
L
L
L--LPV
P
L
QWI
P
K
P
V
L
Y
G
L
F
L
Y
I
A
LTSL
D
G
N
Q
L
V
Q
R
V
A
L
L
L
K
EQTAYP
P
T
H
Y
I
R
RVPQRK
I
H
Y
F
T
G
L
Q
V
L
Q
L
L
L
L
C
A
F
GMSSL
P
Y
M
K
M
I
F
P
L
I
M
I
A
M
I
P
I
R
Y
I
L
L
P
R
I
I
E
A
K
Y
L
D
VMDAEHRP
13
HHSearch
90.55
16%
-48
- C2 -
1HYN
-
B3AT_HUMAN
P:
[56-327]
-----------------------------------------------------------
K
V
YV
E
L
Q
E
L
V
M
D
E
K
N
Q
E
L
R
W
M
E
A
A
R
W
---
V
Q
L
E
E
N
L
G
E
-
N
----------
G
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
----
L
R
R
-
V
F
T
K
G
T
V
L
-
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
--
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
A
G
E
L
E
A
-
L
G
G
V
-
K
P
AVL
T
R
-
S
G
DPSQPLLPQHSSLETQLFCEQGD
G
GTEGHSPSGIL
E
K
I
P
P
D
S
E
A
T
L
V
L
V
-
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
V
E
L
P
-----
V
-
P
I
R
F
L
F
V
L
L
G
P
E
A
P
--
H
I
D
Y
T
-
Q
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
82.50
17%
-84
- C2 -
2A0J
-
?
A:
[3-147]
----------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
-
I
L
P
L
S
H
I
V
-
L
D
M
E
V
G
S
K
K
R
L
F
E
E
A
G
L
L
L
E
R
E
S
S
L
-----
S
H
A
D
V
F
E
C
L
F
A
R
-
E
-----------
K
L
-
G
S
---
T
G
-
L
G
Q----------------------
G
-----------
V
A
I
P
H
----------
G
R
H
A
---
G
-
V
K
Q
A
T
G
A
F
I
R
T
R
E
P
V
G
F
D
A
-
P
-
D
-----
G
K
P
V
S
L
I
F
I
L
L
V
P
E
N
A
--
T
G
E
H
L
-
E
V
L
S
K
L
A
G
K
F
S
Q
K
S
I
R
E
S
L
M
T
V
S
S
A
E
E
V
R
A
I
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
78.65
14%
-77
- C2 -
3T43
-
?
A:
[2-139]
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Q
N
D
I
I
K
A
L
A
S
P
L
I
N
D
G
M
V
------
V
S
D
F
A
D
H
V
I
T
R
-
E
-----------
Q
N
-
A
P
---
T
G
-
L
P
VEP
V
-------------------
G
-----------
V
A
I
P
H
----------
T
D
S
K
---
Y
-
V
R
Q
N
A
I
S
V
G
I
L
A
E
P
V
N
F
E
D
-
A
-
G
GEPDP
V
-
P
V
R
V
V
F
M
L
A
L
G
N
W
----
F
D
I
T
-
N
V
L
W
W
I
M
D
V
I
Q
D
A
D
F
M
Q
Q
L
L
V
M
N
D
D
-
E
I
Y
Q
S
I
Y
T
R
I
S
E
A
A
G
M
A
G
I
H
F
R
R
H
Y
V
R
H
L
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
74.60
14%
-73
* C2 *
1A6J
1
PTSN_ECOLI
A:
[8-157]
---------------------------------------------------------------------------------------------------------------------------------
L
Q
L
S
S
-
V
L
N
R
E
C
T
R
-
S
R
V
H
C
Q
S
K
K
R
A
L
E
I
I
S
E
L
A
A
K
Q
L
S
L
-----
P
P
Q
V
V
F
E
A
I
L
T
R
-
E
-----------
K
M
-
G
S
---
T
G
-
I
G
N----------------------
G
-----------
I
A
I
P
H
----------
G
K
L
E
E--
D
-
T
L
R
A
V
G
V
F
V
Q
L
E
T
P
I
A
F
D
A
-
I
-
D
-----
N
Q
P
V
D
L
L
F
A
L
L
V
P
A
D
Q
--
T
K
T
H
L
-
H
T
L
S
L
V
A
K
R
L
A
D
K
T
I
C
R
R
L
R
A
A
Q
S
D
E
E
L
Y
Q
I
I
T
D
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
73.57
19%
-77
- C2 -
3URR
3
?
A:
[5-152]
----------------------------------------------------------------------------------------------------------------------------------
R
L
A
K
-
I
L
P
L
E
N
V
V
-
I
G
L
S
V
T
S
K
K
R
V
F
E
Q
A
G
L
I
F
E
N
Q
N
G
I
-----
A
R
S
T
V
T
D
N
L
F
A
R
-
E
-----------
R
L
-
G
S
---
T
G
-
L
G
E----------------------
G
-----------
V
A
I
P
H
----------
G
R
I
K
---
G
-
L
K
H
P
L
A
A
F
V
R
L
A
E
P
I
P
F
E
A
-
P
-
D
-----
G
Q
P
V
S
L
L
I
F
L
L
V
P
E
Q
A
--
T
Q
A
H
L
-
E
I
L
S
E
I
A
Q
L
L
S
D
R
D
T
R
E
R
L
H
T
E
P
D
R
D
E
L
H
R
L
L
T
Q
W
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
72.73
11%
-82
- C2 -
3OXP
-
?
A:
[4-149]
----------------------------------------------------------------------------------------------------------------------------------
M
L
K
T
-
L
L
T
S
D
V
I
Q
-
V
V
S
Q
A
K
D
W
R
D
A
I
A
I
S
C
Q
P
L
I
D
N
G
A
V
------
E
A
R
Y
V
E
A
I
Y
R
S
H
E
-----------
A
I
-
G
P
---
Y
Y
V
V
G
P----------------------
G
-----------
I
A
M
P
H
----------
A
R
P
E
D--
G
-
V
N
R
L
S
L
A
L
T
V
I
T
E
G
V
T
F
N
A
-
E
-
G
-----
N
D
P
V
K
L
L
I
V
L
A
A
T
D
S
----
N
S
H
I
-
E
A
I
S
Q
L
A
Q
L
F
D
T
A
S
D
V
Q
A
L
L
N
A
K
T
P
Q
D
I
L
S
V
I
A
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
69.62
16%
-77
- C2 -
1A3A
-
PTM3C_ECOLI
A:
[4-146]
------------------------------------------------------------------------------------------------------------------------------------
L
F
-
K
L
G
A
E
N
I
F
-
L
G
R
K
A
A
T
K
E
E
A
I
R
F
A
G
E
Q
L
V
K
G
G
Y
V
------
E
P
E
Y
V
Q
A
M
L
D
R
-
E
-----------
K
L
-
T
P
---
T
Y
-
L
G
E----------------------
S
-----------
I
A
V
P
H
----------
G
T
V
E
AKD
R
-
V
L
K
T
G
V
V
F
C
Q
Y
P
E
G
V
R
F
G
E
-
E
-
E
D----
D
-
I
A
R
L
V
I
G
I
A
A
R
N
-----
N
E
H
I
-
Q
V
I
T
S
L
T
N
A
L
D
D
E
S
V
I
E
R
L
A
H
T
T
S
V
D
E
V
L
E
L
L
A
G
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
68.46
12%
-35
- C2 -
1A6J
1
PTSN_ECOLI
A:
[8-157]
---------------------------------------------------------------------------------------------------------------------------------
L
Q
L
S
S
-
V
L
N
R
E
C
T
R
-
S
R
V
H
C
Q
S
K
K
R
A
L
E
I
I
S
E
L
A
A
K
Q
L
S
L
P
P
Q
V
V
F
E
A
I
L
T
R
E
K
M
G
S
-
T
G
I
--
G
N
G
I
A
I
P
H
G
-
K
L
-------
E
-----------------------
E
-----------
D
T
-----------------------
L
R
A
V
G
V
F
V
Q
L
E
T
P
I
A
F
D
A
-
I
-
D
-------
N
Q
P
V
D
L
L
F
A
L
L
V
P
A
D
Q
T
K
T
H
L
-
H
T
L
S
L
V
A
K
R
L
A
D
K
T
I
C
R
R
L
R
A
A
Q
S
D
E
E
L
Y
Q
I
I
T
D
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
67.23
12%
-81
- C2 -
3BJV
-
?
A:
[1-149]
---------------------------------------------------------------------------------------------------------------------------------
M
N
L
A
Q
-
A
F
K
E
N
H
S
I
R
L
G
L
T
A
K
D
W
K
E
A
V
K
L
S
V
T
P
L
I
E
S
G
A
V
------
K
P
E
Y
Y
N
A
I
I
E
S
T
E
-----------
S
Y
-
G
P
---
Y
Y
I
L
M
P----------------------
G
-----------
M
A
M
P
H
----------
A
R
P
E
A--
G
-
V
Q
R
D
A
F
S
L
V
T
L
T
E
P
V
T
F
T
D
-
G
-------
K
-
E
V
Q
V
L
L
A
L
A
A
T
S
S
----
K
I
H
T
S
V
A
I
P
Q
I
I
A
L
F
E
L
D
H
S
I
E
R
L
V
N
C
K
T
P
E
E
V
L
A
M
V
E
E
S
K
S
S
P
Y
L
E
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
63.22
15%
-109
- C2 -
3QE7
2
URAA_ECOLI
A:
[41-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
---
P
V
L
L
L
L
-
P
L
G
Y
E
---
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
L
L
----
P
A
E
------------------
G
-------------------------------
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
---------
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
-
V
D
T
T
P
I
---
I
N
A
------
H
W
F
A
L
P
T
L
Y
T
P
R
F
E
W
-----
F
A
I
L
T
I
L
P
-
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
K
D
L
L
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
----------
R
V
Y
---------
S
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
-------------------------------
19
HHSearch
58.54
9%
-75
- C2 -
2OQ3
-
PTMA_ECOLI
A:
[1-146]
---------------------------------------------------------------------------------------------------------------------------------
M
R
L
S
D
-
Y
F
P
E
S
S
I
S
-
V
I
H
S
A
K
D
W
Q
E
A
I
D
F
S
M
V
S
L
L
D
K
N
Y
I
------
S
E
N
Y
I
Q
A
I
K
D
S
-
T
-----------
I
N
N
G
P
Y--
Y
I
-
L
A
P----------------------
G
-----------
V
A
M
P
H
----------
A
R
P
E
---
C
G
A
L
K
T
G
M
S
L
T
L
L
E
Q
G
V
Y
F
P
G
-
N
-
D
-----
E
-
P
I
K
L
L
I
G
L
S
A
A
D
A
----
D
S
H
I
-
G
A
I
Q
A
L
S
E
L
L
C
E
E
E
I
L
E
Q
L
L
T
A
S
S
E
K
Q
L
A
D
I
I
S
R
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.11
25%
-14
- C1 -
4PTF
3
DPOE_YEAST
A:
[429-557]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
R
W
V
K
R
D
S
Y
L
P
Q
G
--------
S
Q
G
L
K
A
V
T
Q
S
K
L
G
Y
N
P
I
E
LDPEL
M
T
P
Y
A
F
E
K
P
Q
--
H
L
S
E
Y
S
-
V
S
D
A
V
A
T
Y
Y
L
Y
M
K
Y
V
H
P
F
I
F
S
L
C
T
I
I
P
L
N
P
D
E
T
L
-
R
K
G
T
G
T
L
C
E
M
L
L
M
V
---------------
Q
A
Y
Q
H
N
I
L
L
P
N
K
H
T
D
P
I
E
R
F
Y
D
G
H
L
L
E
S
E
T
Y
V
G
G
H
V
E
S
L
E
A
G
V
F
R
S
D
L
K
N
E
F
--
K
I
D
P
S
A
I
D
E
L
L
Q
E
L
P
E
A
L
K
F
S
V
E
V
E
N
K
S
S
V
D
K
V
T
N
F
E
E
I
K
N
Q
I
T
Q
K
L
L
E
L
K
E
N
N
I
R
N
E
L
P
L
I
Y
H
V
D
V
A
S
M
Y
P
N
I
M
T
T
N
R
L
Q
P
D
S
I
K
A
E
R
D
A
R
K
L
K
W
A
W
R
G
E
F
F
P
S
K
M
D
E
Y
N
M
I
K
R
A
L
Q
N
E
2
PsiBlast_PDB
54.96
25%
-8
- C1 -
4M8O
3
DPOE_YEAST
A:
[422-550]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
R
W
V
K
R
D
S
Y
L
P
Q
G
--------
S
Q
G
L
K
A
V
T
Q
S
K
L
G
Y
N
P
I
E
L
D
PEL
M
T
P
Y
A
F
E
K
P
Q
--
H
L
S
E
Y
S
-
V
S
D
A
V
A
T
Y
Y
L
Y
M
K
Y
V
H
P
F
I
F
S
L
C
T
I
I
P
L
N
P
D
E
T
L
-
R
K
G
T
G
T
L
C
E
M
L
L
M
V
---------------
Q
A
Y
Q
H
N
I
L
L
P
N
K
H
T
D
P
I
E
R
F
Y
D
G
H
L
L
E
S
E
T
Y
V
G
G
H
V
E
S
L
E
A
G
V
F
R
S
D
L
K
N
E
F
--
K
I
D
P
S
A
I
D
E
L
L
Q
E
L
P
E
A
L
K
F
S
V
E
V
E
N
K
S
S
V
D
K
V
T
N
F
E
E
I
K
N
Q
I
T
Q
K
L
L
E
L
K
E
N
N
I
R
N
E
L
P
L
I
Y
H
V
D
V
A
S
M
Y
P
N
I
M
T
T
N
R
L
Q
P
D
S
I
K
A
E
R
D
C
A
S
C
T
C
A
R
K
L
K
W
A
W
R
G
E
F
F
P
S
K
M
D
E
Y
N
M
I
K
21
HHSearch
44.06
10%
37
- C2 -
2OQT
-
?
A:
[1-151]
---------------------------------------------------------------------------------------------------------------------------------
M
N
L
K
Q
A
L
I
D
N
N
S
I
R
-
L
G
L
S
A
D
T
W
Q
E
A
V
R
L
A
V
Q
P
L
I
D
S
K
A
V
------
T
S
A
Y
Y
D
A
I
I
A
S
T
E
-----------
K
Y
-
G
P
---
Y
Y
V
L
M
P----------------------
G
-----------
M
A
M
P
H
----------
A
E
A
-L--
G
-
V
N
R
N
A
F
A
L
I
T
L
T
K
P
V
T
F
S
D
---
G
-----
K
-
E
V
S
V
L
L
T
L
A
A
T
D
P
----
S
I
H
T
T
V
A
I
P
Q
I
V
A
L
F
E
L
D
N
A
I
E
R
L
V
A
C
Q
S
P
K
E
V
L
E
M
V
E
E
S
K
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
42.45
11%
64
- C2 -
2KPO
-
?
A:
[1-110]
----------------------------------------------------------------
M
L
L
Y
V
L
I
I
S
N
D
K
K
L
I
E
E
A
R
K
M
A
E
K
A
N
L
E
L
R
T
V
K
T
E
D
E
L
K
K
Y
L
E
E
F
R
K
E
S
Q
N
-
I
K
V
L
I
L
V
S
N
D
E
E
L
D
K
A
K
E
-
L
A
Q
K
M
E
I
D
-
V
R
T
R
K
V
T
S
P
D
E
A
K
R
W
I
K
E
F
S
E
E
G
G
S
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
37.90
37%
77
- C1 -
3C6O
2
TIR1_ARATH
B:
[339-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
E
L
R
V
F
P
S
E
-------
P
F
V
M
E
P
N
V
--
A
L
T
E
Q
G
L
V
S
V
S
M
G
C
P
K
L
-
E
S
V
L
Y
F
C
R
Q
M
T
N
A
A
L
I
T
I
A
R
N
R
P
-
N
M
T
R
F
R
L
C
I
I
E
P
K
A
P
D
Y
L
T
L
E
P
L
D
I
G
F
G
A
I
V
E
H
C
K
D
L
R
R
L
S
L
S
G
L
L
T
D
K
V
F
E
Y
I
G
T
Y
A
K
K
M
E
M
L
S
V
A
F
A
G
D
S
D
L
G
M
H
H
V
L
S
--
G
C
D
S
L
R
K
L
E
I
R
D
C
P
F
G
D
K
A
L
L
A
N
A
S
K
L
E
T
M
R
S
L
W
M
S
S
C
S
V
S
F
G
A
C
K
L
L
G
Q
K
M
P
K
L
N
V
E
V
I
D
E
R
G
A
P
D
S
R
P
E
S
C
P
V
E
R
V
F
I
Y
R
T
V
A
G
P
R
F
D
M
P
G
F
V
W
N
M
----------------------
4
PsiBlast_PDB
37.84
37%
75
- C1 -
2P1M
1
TIR1_ARATH
B:
[339-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
E
L
R
V
F
P
S
E
-------
P
F
V
M
E
P
N
V
--
A
L
T
E
Q
G
L
V
S
V
S
M
G
C
P
K
L
-
E
S
V
L
Y
F
C
R
Q
M
T
N
A
A
L
I
T
I
A
R
N
R
P
-
N
M
T
R
F
R
L
C
I
I
E
P
K
A
P
D
Y
L
T
L
E
P
L
D
I
G
F
G
A
I
V
E
H
C
K
D
L
R
R
L
S
L
S
G
L
L
T
D
K
V
F
E
Y
I
G
T
Y
A
K
K
M
E
M
L
S
V
A
F
A
G
D
S
D
L
G
M
H
H
V
L
S
--
G
C
D
S
L
R
K
L
E
I
R
D
C
P
F
G
D
K
A
L
L
A
N
A
S
K
L
E
T
M
R
S
L
W
M
S
S
C
S
V
S
F
G
A
C
K
L
L
G
Q
K
M
P
K
L
N
V
E
V
I
D
E
R
G
A
P
D
S
R
P
E
S
C
P
V
E
R
V
F
I
Y
R
T
V
A
G
P
R
F
D
M
P
G
F
V
W
N
M
----------------------
8
PsiBlast_PDB
37.67
37%
73
* C1 *
2P1Q
3
TIR1_ARATH
B:
[339-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
E
L
R
V
F
P
S
E
-------
P
F
V
M
E
P
N
V
--
A
L
T
E
Q
G
L
V
S
V
S
M
G
C
P
K
L
-
E
S
V
L
Y
F
C
R
Q
M
T
N
A
A
L
I
T
I
A
R
N
R
P
-
N
M
T
R
F
R
L
C
I
I
E
P
K
A
P
D
Y
L
T
L
E
P
L
D
I
G
F
G
A
I
V
E
H
C
K
D
L
R
R
L
S
L
S
G
L
L
T
D
K
V
F
E
Y
I
G
T
Y
A
K
K
M
E
M
L
S
V
A
F
A
G
D
S
D
L
G
M
H
H
V
L
S
--
G
C
D
S
L
R
K
L
E
I
R
D
C
P
F
G
D
K
A
L
L
A
N
A
S
K
L
E
T
M
R
S
L
W
M
S
S
C
S
V
S
F
G
A
C
K
L
L
G
Q
K
M
P
K
L
N
V
E
V
I
D
E
R
G
A
P
D
S
R
P
E
S
C
P
V
E
R
V
F
I
Y
R
T
V
A
G
P
R
F
D
M
P
G
F
V
W
N
M
----------------------
5
PsiBlast_PDB
37.46
37%
89
- C1 -
2P1N
3
TIR1_ARATH
B:
[339-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
E
L
R
V
F
P
S
E
-------
P
F
V
M
E
P
N
V
--
A
L
T
E
Q
G
L
V
S
V
S
M
G
C
P
K
L
-
E
S
V
L
Y
F
C
R
Q
M
T
N
A
A
L
I
T
I
A
R
N
R
P
-
N
M
T
R
F
R
L
C
I
I
E
P
K
A
P
D
Y
L
T
L
E
P
L
D
I
G
F
G
A
I
V
E
H
C
K
D
L
R
R
L
S
L
S
G
L
L
T
D
K
V
F
E
Y
I
G
T
Y
A
K
K
M
E
M
L
S
V
A
F
A
G
D
S
D
L
G
M
H
H
V
L
S
--
G
C
D
S
L
R
K
L
E
I
R
D
C
P
F
G
D
K
A
L
L
A
N
A
S
K
L
E
T
M
R
S
L
W
M
S
S
C
S
V
S
F
G
A
C
K
L
L
G
Q
K
M
P
K
L
N
V
E
V
I
D
E
R
G
A
P
D
S
R
P
E
S
C
P
V
E
R
V
F
I
Y
R
T
V
A
G
P
R
F
D
M
P
G
F
V
W
N
M
D
Q
--------------------
6
PsiBlast_PDB
37.40
37%
75
- C1 -
2P1O
3
TIR1_ARATH
B:
[339-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
E
L
R
V
F
P
S
E
-------
P
F
V
M
E
P
N
V
--
A
L
T
E
Q
G
L
V
S
V
S
M
G
C
P
K
L
-
E
S
V
L
Y
F
C
R
Q
M
T
N
A
A
L
I
T
I
A
R
N
R
P
-
N
M
T
R
F
R
L
C
I
I
E
P
K
A
P
D
Y
L
T
L
E
P
L
D
I
G
F
G
A
I
V
E
H
C
K
D
L
R
R
L
S
L
S
G
L
L
T
D
K
V
F
E
Y
I
G
T
Y
A
K
K
M
E
M
L
S
V
A
F
A
G
D
S
D
L
G
M
H
H
V
L
S
--
G
C
D
S
L
R
K
L
E
I
R
D
C
P
F
G
D
K
A
L
L
A
N
A
S
K
L
E
T
M
R
S
L
W
M
S
S
C
S
V
S
F
G
A
C
K
L
L
G
Q
K
M
P
K
L
N
V
E
V
I
D
E
R
G
A
P
D
S
R
P
E
S
C
P
V
E
R
V
F
I
Y
R
T
V
A
G
P
R
F
D
M
P
G
F
V
W
N
M
D
Q
--------------------