@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S4A7_HUMAN: (2015-12-11 )
MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFEDEPRKKYVDAETSL
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.-.......130.......140.......150.......160.......170.......180.......190.......200.......210....--...220.......230.......240.......250.......260.......270.......280.......290--------------........300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.....---.-.440.......450.......460-.--.......470.......480-.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630...----....640.......650.....-..660.......670.......680.......690.......700.......710--.-........720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940...-....950.......960.......970.......980.......990.......1000......1010......1020.---.....1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MERFRLEKKLPGP
D
E
E
A
V
V
DLGKTSSTVNTKF
E
K
E
E
L
ESH
R
A
V
Y
I
G
V
HVPF
S
K
E
S
R
R
R
H
RHRG
H
K
H
H
H
R
RRKDKESDKEDGRESPSYD
T
P
S
Q
R
V
Q
F
I
LGTEDDDEEHI
P
H
D
L
F
T
E
M
D
E
L
C
Y-R-DGEE
Y
E
W
K
E
T
A
R
W
L
K
F
E
E
D
V
EDGGDRWSK
P
Y
V
A
T
L
S
L
H
S
L
F
E
L
R
S
C
ILN
G
T
V
M
L
D
M
R
A
S
T
L
D
E
I
A
D
M
V
L
D
N
M
IASGQL
D
E
S
I
R
E
N
V
R
E
A
L
L
K
R
H--HH
Q
N
E
K
R
F
T
S
R
I
P
L
V
R
S
F
A
D
IGKKHSDP
H
L
L
ERNGEGLS
A
S
R
H
S
L
RTGLSASNLSLRGES
P
L
S
L
L
L
G
H
LLPSSRA---------------GTPAGSRCTTPVPTPQNSPPSSP
S
I
S
R
L
TSRSS
Q
E
S
Q
RQAP
E
L
L
VSPASDDI
P
T
V
V
I
HP
P
E
E
D
L
E
A
A
LKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSG
E
I
K
GNGSGGSRENS
T
V
D
F
S
K
V
D
M
N
F
M
R
KIPTGAEAS
N
V
L
V
G
E
V
D
---
F
-
L
E
R
P
I
I
A
F
V
R
L
A
P
A
V
L
L
TGLTEV--P--VP
T
R
F
L
F
L
L
LGPAGKA
P
Q
Y
H
-
E
I
G
R
S
I
A
T
L
M
T
D
E
I
F
H
D
V
A
YKAK
D
R
N
D
L
L
S
G
I
D
E
F
L
D
QVTVLPPGEWDP
S
I
R
IEPPKSVP
S
Q
E
KRK
I
P
V
F
HNGSTPTLGE
T
P
K
E
A
A
HHAG
P
E
L
Q
R
T
G
R
L
F
G
G
L
I
L
D
IKRKAP
F
F
L
S
D
F
K
D
A
L
S
L
Q
C
L
A
S
I
L
F
L
Y
C
A
C
M
S
P
V
I
T
F
G
G
LLGEATE----
G
R
I
S
A
I
E
S
L
F
G
A
S
L
T
G
I
A
Y
S
LF-AGQ
P
L
T
I
LGST
G
P
V
L
V
F
E
K
I
L
Y
K
F
C
R
D
Y
Q
L
S
Y
L
S
L
R
TSI
G
L
W
T
S
F
L
C
I
V
L
VAT----D-A
S
S
L
V
C
Y
I
T
R
F
T
E
E
A
F
A
A
L
I
C
I
I
F
I
Y
E
A
L
E
K
L
F
DLGE
T
Y
A
FNMHN
N
L
D
K
LTS
Y
S
C
V
CTEPPNPS
N
E
T
L
A
Q
W
KKDNITAHNISWRNL
T
V
S
E
C
K
K
L
R
G
V
F
LGSACGHHGPY
I
P
D
V
L
F
W
C
V
I
L
F
F
T
T
F
F
L
S
S
F
L
K
Q
F
K
TKRYF
P
T
K
V
R
S
T
I
S
D
F
A
V
F
L
T
I
V
I
M
V
T
I
D
Y
L
VGVPSPKLHVPEKFEPTHPERG
W
I
ISPLGDNP
W
W
T
L
L
I
A
A
I
P
A
L
L
C
T
I
L
I
F
MDQQ
I
T
A
V
I
I
NRK
E
H
K
L-KKGAG
Y
H
L
D
L
L
M
V
G
V
M
L
G
V
C
S
VMG
L
P
W
F
V
A
A
T
V
L
S
I
SHVN
S
L
K
VESECSAPGEQP
K
F
L
G
I
R
E
Q
R
V
T
G
L
M
I
F
I
L
M
G
L
S
V
F
---
M
T
S
V
L
K
FI
P
M
P
V
L
Y
G
V
F
L
Y
M
G
V
S
SLK
G
I
Q
L
F
D
R
I
K
L
FGMPAKHQP
D
L
I
Y
L
R
YVPL
W
K
V
H
I
F
T
V
I
Q
L
T
C
L
V
L
L
W
V
I
K
V
S
A
A
A
V
V
F
P
M
M
V
L
A
L
V
F
V
R
K
L
M
D
L
C
F
T
K
R
E
L
S
W
L
D
D
LMPESKKKKE
D
D
K
K
K
K
E
K
E
E
A
E
R
M
LQDDD
D
T
V
H
L
PFEGG
S
L
L
Q
I
P
V
K
A
LKYSPDK
P
V
S
V
K
I
S
FEDEP
R
K
KYVDAETSL
23
Fugue
93.18
33%
-40
- C2 -
1HYN
-
B3AT_HUMAN
P:
[56-348]
--------------------------------------------------------------------------------------------------------------
K
V
Y
V
E
L
Q
E
L
V
M
D
E
-
K
N
Q
E
L
R
W
M
E
A
A
R
W
V
Q
L
E
E
N
L
G
E
N
G
-
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
V
F
T
K
G
T
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
H
--
S
H
A
G
E
L
E
A
L
G
---------------------------------------------------------------------------------------------------
G
V
K
P
A
V
L
T
R
S
G
D
P
S
Q
P
L
L
P
Q
H
S
S
L
E
T
Q
L
F
C
E
---------------------------------------------------------------
Q
G
D
G
G
T
E
G
H
S
P
S
G
I
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
V
-
E
L
--
P
--
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
89.55
31%
-44
- C2 -
1HYN
-
B3AT_HUMAN
P:
[56-348]
--------------------------------------------------------------------------------------------------------------
K
V
Y
V
E
L
Q
E
L
V
M
-
D
E
K
N
Q
E
L
R
W
M
E
A
A
R
W
V
Q
L
E
E
N
L
G
E
-
N
G
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
V
F
T
K
G
T
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
H
--
S
H
A
G
E
L
E
A
L
G
G
V
K
-
P
A
V
L
T
R
S
G
D
P
-------------------------------------------------------------------------
S
Q
-
P
----
L
-
L
P
-
Q
H
S
S
L
E
T
Q
--------------------------------------------------
L
-----------
F
---
C
----------
E
--
Q
G
---
D
G
G
--
T
E
G
H
S
P
S
G
I
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
-
V
E
L
--
P
--
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
63.93
44%
-33
- C2 -
1HYN
-
B3AT_HUMAN
P:
[203-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
D
G
G
T
E
G
H
S
P
S
-------
G
I
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
V
-
E
L
--
P
--
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
55.11
13%
-130
- C2 -
3QE7
2
URAA_ECOLI
A:
[9-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
P
P
-
L
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
---
T
V
L
V
P
V
L
F
H
----------------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
---
P
V
L
L
L
L
-
P
L
G
Y
E
V
A
---
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
-
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
-
G
L
L
---
P
A
E
--------------------
G
-----------------------------------------------
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
-
G
--------
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
-
P
I
I
--------
N
A
H
W
F
A
L
P
T
L
Y
T
P
R
F
E
-
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
K
D
L
L
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
----------
R
V
--------
Y
S
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
-----------------------------------------------------------------------------------------------------
15
HHSearch
50.55
27%
-1
- C2 -
3URR
3
?
A:
[67-152]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
H
G
R
I
K
---
G
-
L
K
H
P
L
A
A
F
V
R
L
A
E
P
I
P
F
E
A
P
D
G
------
Q
P
V
S
L
L
I
F
L
L
V
P
E
Q
A
T
Q
A
H
L
-
E
I
L
S
E
I
A
Q
L
L
S
D
R
D
T
R
E
R
L
H
T
E
P
D
R
D
E
L
H
R
L
L
T
Q
W
Q
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
47.54
19%
14
- C2 -
1A6J
-
PTSN_ECOLI
A:
[71-157]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
H
G
K
L
E
E--
D
-
T
L
R
A
V
G
V
F
V
Q
L
E
T
P
I
A
F
D
A
I
D
N
------
Q
P
V
D
L
L
F
A
L
L
V
P
A
D
Q
T
K
T
H
L
-
H
T
L
S
L
V
A
K
R
L
A
D
K
T
I
C
R
R
L
R
A
A
Q
S
D
E
E
L
Y
Q
I
I
T
D
T
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
46.38
14%
11
- C2 -
3BJV
-
?
A:
[66-151]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
H
A
R
P
E
A--
G
-
V
Q
R
D
A
F
S
L
V
T
L
T
E
P
V
T
F
T
D
--
G
------
K
E
V
Q
V
L
L
A
L
A
A
T
S
S
--
K
I
H
T
S
V
A
I
P
Q
I
I
A
L
F
E
L
D
H
S
I
E
R
L
V
N
C
K
T
P
E
E
V
L
A
M
V
E
E
S
K
S
S
P
Y
L
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
46.10
31%
62
- C2 -
3URR
3
?
A:
[70-144]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
K
---
G
-
L
K
H
P
L
A
A
F
V
R
L
A
E
P
I
P
F
----
E
A
--
P
DG
Q
P
V
S
L
L
I
F
L
L
V
P
E
Q
A
T
Q
A
H
L
-
E
I
L
S
E
I
A
Q
L
L
S
D
R
D
T
R
E
R
L
H
T
E
P
D
R
D
E
L
H
R
L
L
T
Q
W
Q
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
46.03
15%
16
* C2 *
2A0J
-
?
A:
[63-147]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
P
H
G
R
H
A
---
G
-
V
K
Q
A
T
G
A
F
I
R
T
R
E
P
V
G
F
D
A
P
D
G
------
K
P
V
S
L
I
F
I
L
L
V
P
E
N
A
T
G
E
H
L
-
E
V
L
S
K
L
A
G
K
F
S
Q
K
S
I
R
E
S
L
M
T
V
S
S
A
E
E
V
R
A
I
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
46.00
31%
59
- C2 -
4GQX
-
?
A:
[80-154]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
K
---
G
-
L
K
H
P
L
A
A
F
V
R
L
A
E
P
I
P
F
----
E
A
--
P
DG
Q
P
V
S
L
L
I
F
L
L
V
P
E
Q
A
T
Q
A
H
L
-
E
I
L
S
E
I
A
Q
L
L
S
D
R
D
T
R
E
R
L
H
T
E
P
D
R
D
E
L
H
R
L
L
T
Q
W
Q
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
45.97
16%
-17
- C2 -
3T43
-
?
A:
[48-141]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
P
H
T
D
S
K
---
Y
-
V
R
Q
N
A
I
S
V
G
I
L
A
E
P
V
N
F
E
D
A
G
G
E
PD
P
--
V
P
V
R
V
V
F
M
L
A
L
G
N
W
--
F
D
I
T
-
N
V
L
W
W
I
M
D
V
I
Q
D
A
D
F
M
Q
Q
L
L
V
M
N
D
D
-
E
I
Y
Q
S
I
Y
T
R
I
S
E
A
A
G
M
A
G
I
H
F
R
R
H
Y
V
R
H
L
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
45.64
18%
5
- C2 -
3OXP
-
?
A:
[65-150]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
M
P
H
A
R
P
E
D--
G
-
V
N
R
L
S
L
A
L
T
V
I
T
E
G
V
T
F
N
A
E
G
N
------
D
P
V
K
L
L
I
V
L
A
A
T
D
S
--
N
S
H
I
-
E
A
I
S
Q
L
A
Q
L
F
D
T
A
S
D
V
Q
A
L
L
N
A
K
T
P
Q
D
I
L
S
V
I
A
R
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
43.86
11%
20
- C2 -
1A3A
-
PTM3C_ECOLI
A:
[65-147]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
G
T
V
E
AKD
R
-
V
L
K
T
G
V
V
F
C
Q
Y
P
E
G
V
R
F
G
E
E
E
D
------
D
I
A
R
L
V
I
G
I
A
A
R
N
N
---
E
H
I
-
Q
V
I
T
S
L
T
N
A
L
D
D
E
S
V
I
E
R
L
A
H
T
T
S
V
D
E
V
L
E
L
L
A
G
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
42.78
13%
5
- C2 -
2OQ3
-
PTMA_ECOLI
A:
[64-146]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
P
H
A
R
P
E
---
C
G
A
L
K
T
G
M
S
L
T
L
L
E
Q
G
V
Y
F
P
G
N
D
-------
E
P
I
K
L
L
I
G
L
S
A
A
D
A
--
D
S
H
I
-
G
A
I
Q
A
L
S
E
L
L
C
E
E
E
I
L
E
Q
L
L
T
A
S
S
E
K
Q
L
A
D
I
I
S
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
41.27
14%
64
- C2 -
2OQT
-
?
A:
[68-151]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
E
A
-L--
G
-
V
N
R
N
A
F
A
L
I
T
L
T
K
P
V
T
F
S
D
--
G
------
K
E
V
S
V
L
L
T
L
A
A
T
D
P
--
S
I
H
T
T
V
A
I
P
Q
I
V
A
L
F
E
L
D
N
A
I
E
R
L
V
A
C
Q
S
P
K
E
V
L
E
M
V
E
E
S
K
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
36.02
24%
83
- C1 -
3G9H
-
A:
[162-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
P
I
A
P
I
V
I
H
P
V
W
R
F
E
S
H
Q
A
S
V
V
L
T
V
K
M
S
P
S
L
P
D
E
I
S
Q
I
V
I
E
D
L
V
V
F
V
N
I
D
G
A
---
N
A
T
S
A
L
S
K
P
Q
G
S
F
S
K
E
K
K
R
I
T
W
R
F
-------------
K
E
P
V
V
L
T
R
N
G
E
G
Q
R
L
I
A
R
F
I
T
D
G
L
A
H
E
S
A
K
G
V
I
T
K
F
T
I
S
E
T
D
N
V
A
L
P
H
S
G
---------------
A
G
S
G
I
T
L
T
C
Q
E
L
D
E
N
N
P
F
G
G
E
W
L
D
V
N
T
K
R
T
L
T
T
G
N
Y
H
G
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
33.75
29%
535
- C3 -
3J7Y
-
RM14_HUMAN
L:
[75-125]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
K
G
Q
K
K
K
A
L
I
V
G
H
C
M
P
G
P
R
M
TPRFDSNNVVLIEDN
G
N
P
V
G
T
R
I
K
T
P
I
P
T
S
L
R
K
R
E
G
E
Y
S
K
V
L
A
I
A
Q
N
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
33.73
14%
17
- C2 -
3QE7
2
URAA_ECOLI
A:
[226-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
KDLL
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
-
G
S
T
P
N
T
T
Y
G
E
N
--
I
G
V
--------
M
A
I
T
R
V
---
Y
S
-
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
----
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
31.96
29%
525
* C3 *
4V19
-
?
O:
[75-125]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
R
G
Q
K
K
K
A
L
I
V
G
H
R
M
P
G
P
R
M
TPRFDSNNVVLLEDN
G
N
P
V
G
T
R
I
K
T
P
I
P
S
S
L
R
Q
R
E
G
E
F
S
K
V
L
A
I
A
Q
N
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
29.76
29%
597
- C3 -
4CE4
-
?
O:
[75-125]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
R
G
Q
K
K
K
A
L
I
V
G
H
R
M
P
G
P
R
M
TPRFDSNNVVLLEDN
G
N
P
V
G
T
R
I
K
T
P
I
P
S
S
L
R
Q
R
E
G
E
F
S
K
V
L
A
I
A
Q
N
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
23.82
57%
320
- C2 -
1BZK
1
?
?:
[1-42]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
P
Y
Y
L
S
D
I
T
D
A
F
S
P
Q
V
L
A
A
V
I
F
I
Y
F
A
A
L
S
P
A
I
T
F
G
G
L
L
G
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------