@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S4A8_HUMAN: (2015-12-11 )
MPAAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKAKEEEEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120...-.-.-..130.......140.......150.......160.......170....----..-..180.......190.......200.......210.......-220...-....230.......-240.---.......250.......260.......--.270.......280.......290.......300.......---310........320.......330.--.--.....340.......350..-.-....360.......370.......380.......390.......400....-----...410.......420.......430.......440.......450.......460.......470.......480.......490.......500...----....510.......520.....-..530.......540.......550.......560.......570.......580--.-........590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810...-....820.......830.......840.......850.......860.......870.......880.......890..---.....900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPAAGSNEPDG
V
L
SYQRPD
E
E
AVVDQGGT
S
T
I
L
N
I
H
Y
E
K
E
ELEGH
R
T
L
Y
V
G
V
RMPLGRQSHRHHRTH
G
Q
K
H
R
RRGRGKGAS
Q
G
E
E
G
L
E
A
L
AHDT
P
S
Q
R
V
Q
F
I
LGTEEDEEHV
P
H
E
L
F
T
E
L
D
E
I
C
M
-K-E-GED
A
E
W
K
E
T
A
R
W
L
K
F
E
E
D
V
E
DG
G
E
RWSK
P
Y
V
A
T
L
S
L
H
S
L
F
E
L
R
S
-
C
LIN----
G
T
-
V
L
L
D
MHAN
S
I
E
E
I
S
D
L
IL
D
Q
Q
E
L
S
SDLN
D
S
M
R
V
K
V
R
E
A
L
L
K
K
-
H
HHQ
N
E
-
K
KRNN
L
I
P
I
V
R
S
F
A
-
E
-VG---KKQSDPH
L
M
DKHGQTVSPQ-SVPTT
N
L
--
E
VKNGVNCEHSPVD
L
S
K
V
D
L
H
F
M
K
KIPTGAEAS
N
V
L
V
GEVD---I-LDR
P
I
V
A
F
V
RL
S
P
A
V
L
L
S
G
L
TEV--P--IP
T
R
F
L
F
I
L
LGPVGKG
Q
Q
Y
H
-
E
-
I
G
R
S
M
A
T
I
M
T
D
E
I
F
H
D
V
A
YKAK
E
R
D
D
L
L
A
G
I
D
E
F
L
D
QVTVLPPGEWDP
S
I
R
-----IEPPKNVP
S
Q
E
K
RKMPGVPNG
N
V
C
H
I
EQEPHGGHSG
P
E
L
Q
R
T
G
R
L
F
G
G
L
V
L
D
I
KRKAPWY
W
S
D
Y
R
D
A
L
S
L
Q
C
L
A
S
F
L
F
L
Y
C
A
C
M
S
P
V
I
T
F
G
G
LLGEATE----
G
R
I
S
A
I
E
S
L
F
GA
S
M
T
G
I
A
Y
S
LF-AG
Q
A
L
T
I
LGST
G
P
V
L
V
F
E
K
I
L
F
K
F
C
K
D
Y
A
L
S
Y
L
S
L
R
A
C
I
G
L
W
T
A
F
L
C
I
V
L
VAT----D-A
S
S
L
V
C
Y
I
T
R
F
T
E
E
A
F
A
S
L
I
C
I
I
F
I
Y
E
A
I
E
K
L
I
H
L
A
E
TY
P
I
HMHSQLDH
L
S
L
Y
Y
C
R
CTLPENPNNH
T
L
Q
Y
WKDH
N
I
V
T
A
E
V
H
WANL
T
V
S
E
C
Q
E
M
H
G
E
F
M
G
S
ACGHHGPYT
P
D
V
L
F
W
S
C
I
L
F
F
T
T
F
I
L
S
S
T
L
K
T
F
KTSRY
F
P
T
R
V
R
S
M
V
S
D
F
A
V
F
L
T
I
F
T
M
V
I
I
D
F
L
IGVPSPKLQVPSVFKPTRDDR
G
W
I
INPIGP
N
P
W
W
T
V
I
A
A
I
I
P
A
L
L
C
T
I
L
I
F
MDQQ
I
T
A
V
I
I
NR
K
E
H
K
L
-
K
KGCG
Y
H
L
D
L
L
M
V
A
I
M
L
G
V
C
S
IMG
L
P
W
F
V
A
A
T
V
L
S
I
T
H
V
N
S
L
K
LESECSAPGEQP
K
F
L
G
I
R
E
Q
R
V
T
G
L
M
I
F
V
L
MG
C
S
V
F
---
M
T
A
I
L
K
FI
P
M
P
V
L
Y
G
V
F
L
Y
M
G
V
S
SL
Q
G
I
Q
F
F
D
R
L
K
L
FGMPAKHQP
D
F
I
Y
L
RHVPL
R
K
V
H
L
F
T
L
I
Q
L
T
C
L
V
L
L
W
V
IKASP
A
A
I
V
F
P
M
M
V
L
A
L
V
F
V
R
K
V
M
D
L
C
FSK
R
E
L
S
W
L
D
D
LM
P
E
S
K
K
K
K
L
D
D
A
K
K
K
A
K
E
E
E
E
A
E
K
M
L
E
IGGDKFPL
E
S
R
K
L
LSSPGK
N
I
S
C
R
CDPSEINISDEMPKT
T
V
W
K
A
L
SMNSGNAKEKSLFN
2
PsiBlast_PDB
91.43
33%
-40
- C3 -
1HYN
-
B3AT_HUMAN
P:
[56-348]
------------------------------------------------------------------------------------------------------------------
K
V
Y
V
E
L
Q
E
L
V
M
-
D
-
E
K
N
Q
E
L
R
W
M
E
A
A
R
W
V
Q
L
E
E
N
L
G
E
N
G
-
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
-
V
F
T
K
----
G
T
-
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
A
G
E
L
E
A
L
G
G
V
K
P
A
V
L
T
-----------
R
S
G
D
P
------
S
Q
P
L
L
P
Q
H
S
S
L
E
T
Q
L
FC
E
Q
G
D
G
G
T
E
G
H
S
P
S
G
I
-------
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
V
-
E
L
--
P
--
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
-
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
-
P
S
E
Q
ALLSL
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.01
35%
-51
- C3 -
4KY9
-
B3AT_HUMAN
A:
[7-273]
-------------------------------------------------------------------------------------------------------------------
V
Y
V
E
L
Q
E
L
V
M
-
D
-
E
K
N
Q
E
L
R
W
M
E
A
A
R
W
V
Q
L
E
E
N
L
G
E
N
G
A
-
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
-
V
F
T
K
----
G
T
-
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
A
G
E
L
E
A
L
G
G
V
K
P
A
V
L
T
-----------
R
---
P
------
S
Q
P
L
L
P
Q
H
S
S
L
E
T
Q
L
FC
E
----------------------
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
V
-
E
L
--
P
--
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
-
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
-----
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
89.23
31%
-39
* C3 *
1HYN
-
B3AT_HUMAN
P:
[56-348]
------------------------------------------------------------------------------------------------------------------
K
V
Y
V
E
L
Q
E
L
V
M
D
E
-
K
-
N
Q
E
L
R
W
M
E
A
A
R
W
V
Q
L
E
E
N
L
G
E
N
G
-
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
-
V
F
T
K
----
G
T
-
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
A
G
E
-
L
E
A
L
G
--
G
V
K
P
A
V
L
-
T
-
R
S
---
G
D
P
S
Q
P
L
L
--------------
P
Q
H
S
S
--
L
E
T
Q
L
F
C
E
Q
G
D
G
G
T
E
G
H
S
P
S
G
I
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
V
-
E
L
--
P
--
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
-
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
-----
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
88.00
30%
-33
- C3 -
1HYN
-
B3AT_HUMAN
P:
[56-348]
------------------------------------------------------------------------------------------------------------------
K
V
Y
V
E
L
Q
E
L
V
M
-
D
E
K
-
N
Q
E
L
R
W
M
E
A
A
R
W
V
Q
L
E
E
N
L
G
E
-
N
G
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
-
V
F
T
K
----
G
T
-
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
A
G
E
-
L
E
A
L
G
G
V
K
-
P
A
V
L
T
-
R
-
S
G
---
D
P
-
S
Q
P
L
L
---------
P
Q
-
H
-
S
S
-----
L
E
T
Q
L
F
C
E
Q
G
D
G
G
T
E
G
H
S
P
S
G
I
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
-
V
E
L
--
P
--
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
-
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
-----
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
60.55
22%
-53
- C3 -
3URR
3
?
A:
[2-152]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
N
R
L
A
K
-
I
L
P
L
----
E
N
-
V
V
I
G
L
S
V
T
S
K
K
R
V
F
E
Q
A
G
L
I
F
E
N
Q
N
G
I
---
A
R
S
T
V
T
D
N
L
F
A
R
-
E
R
L
---------------
G
S
T
-
G
-
L
G
---
E
G
V
--------------------------------------------------
A
I
P
H
---------
G
R
I
K
---
G
-
L
K
H
P
L
A
A
F
V
R
L
A
E
P
I
P
F
E
A
P
D
G
------
Q
P
V
S
L
L
I
F
L
L
V
P
E
Q
A
T
Q
A
H
L
-
E
-
I
L
S
E
I
A
Q
L
L
S
D
R
D
T
R
E
R
L
H
T
E
P
D
R
D
E
L
H
R
L
L
T
Q
W
Q
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
55.45
20%
-51
- C3 -
2A0J
-
?
A:
[4-147]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
-
I
L
P
L
----
S
H
-
I
V
L
D
M
E
V
G
S
K
K
R
L
F
E
E
A
G
L
L
L
E
R
E
S
S
L
S
---
H
A
D
V
F
E
C
L
F
A
R
-
E
K
L
---------------
G
S
T
-
G
-
L
G
---
Q
G
V
--------------------------------------------------
A
I
P
H
---------
G
R
H
A
---
G
-
V
K
Q
A
T
G
A
F
I
R
T
R
E
P
V
G
F
D
A
P
D
G
------
K
P
V
S
L
I
F
I
L
L
V
P
E
N
A
T
G
E
H
L
-
E
-
V
L
S
K
L
A
G
K
F
S
Q
K
S
I
R
E
S
L
M
T
V
S
S
A
E
E
V
R
A
I
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
54.05
20%
-46
- C3 -
1A6J
1
PTSN_ECOLI
A:
[8-157]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
S
S
-
V
L
N
R
----
E
C
-
T
R
S
R
V
H
C
Q
S
K
K
R
A
L
E
I
I
S
E
L
A
A
K
Q
L
S
L
---
P
P
Q
V
V
F
E
A
I
L
T
R
-
E
K
M
---------------
G
S
T
-
G
-
I
G
---
N
G
I
--------------------------------------------------
A
I
P
H
---------
G
K
L
E
E--
D
-
T
L
R
A
V
G
V
F
V
Q
L
E
T
P
I
A
F
D
A
I
D
N
------
Q
P
V
D
L
L
F
A
L
L
V
P
A
D
Q
T
K
T
H
L
-
H
-
T
L
S
L
V
A
K
R
L
A
D
K
T
I
C
R
R
L
R
A
A
Q
S
D
E
E
L
Y
Q
I
I
T
D
T
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
53.12
15%
-48
- C3 -
1A3A
-
PTM3C_ECOLI
A:
[4-147]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
-
K
L
G
A
----
E
N
-
I
F
L
G
R
K
A
A
T
K
E
E
A
I
R
F
A
G
E
Q
L
V
K
G
G
Y
V
E
----
P
E
Y
V
Q
A
M
L
D
R
-
E
K
L
---------------
T
P
T
-
Y
-
L
G
---
E
S
I
--------------------------------------------------
A
V
P
H
---------
G
T
V
E
AKD
R
-
V
L
K
T
G
V
V
F
C
Q
Y
P
E
G
V
R
F
G
E
E
E
----
D
--
D
I
A
R
L
V
I
G
I
A
A
R
N
N
---
E
H
I
-
Q
-
V
I
T
S
L
T
N
A
L
D
D
E
S
V
I
E
R
L
A
H
T
T
S
V
D
E
V
L
E
L
L
A
G
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
53.08
12%
-147
- C3 -
3QE7
2
URAA_ECOLI
A:
[9-341]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
P
P
-
L
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
---
T
V
L
V
P
V
L
F
H
----------------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
---
P
V
L
L
L
L
-
P
L
G
Y
E
V
A
---
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
-
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
L
-
L
---
P
A
E
G
-------------------------------------------------------------------
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
-
G
F
--------
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
-
P
I
I
--------
N
A
H
W
F
A
L
P
T
L
Y
T
P
R
F
E
-
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
K
D
L
L
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
----------
R
V
--------
Y
S
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
--------------------------------------------------------------------------------------------------------------
18
HHSearch
50.79
15%
-42
- C3 -
3OXP
-
?
A:
[4-150]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
T
-
L
L
T
S
----
D
V
-
I
Q
V
V
S
Q
A
K
D
W
R
D
A
I
A
I
S
C
Q
P
L
I
D
N
G
A
V
E
----
A
R
Y
V
E
A
I
Y
R
S
H
E
A
I
---------------
G
P
Y
Y
V
-
V
G
---
P
G
I
--------------------------------------------------
A
M
P
H
---------
A
R
P
E
D--
G
-
V
N
R
L
S
L
A
L
T
V
I
T
E
G
V
T
F
N
A
E
G
N
------
D
P
V
K
L
L
I
V
L
A
A
T
D
S
--
N
S
H
I
-
E
-
A
I
S
Q
L
A
Q
L
F
D
T
A
S
D
V
Q
A
L
L
N
A
K
T
P
Q
D
I
L
S
V
I
A
R
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
49.08
13%
-51
- C3 -
3BJV
-
?
A:
[2-149]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
A
Q
-
A
F
K
E
----
N
H
S
I
R
L
G
L
T
A
K
D
W
K
E
A
V
K
L
S
V
T
P
L
I
E
S
G
A
V
----
K
P
E
Y
Y
N
A
I
I
E
S
T
E
S
Y
---------------
G
P
Y
-
Y
I
L
M
---
P
G
M
--------------------------------------------------
A
M
P
H
---------
A
R
P
E
A--
G
-
V
Q
R
D
A
F
S
L
V
T
L
T
E
P
V
T
F
T
D
--
G
------
K
E
V
Q
V
L
L
A
L
A
A
T
S
S
--
K
I
H
T
S
V
-
A
I
P
Q
I
I
A
L
F
E
L
D
H
S
I
E
R
L
V
N
C
K
T
P
E
E
V
L
A
M
V
E
E
S
K
S
S
P
Y
L
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
48.40
11%
-42
- C3 -
2OQ3
-
PTMA_ECOLI
A:
[2-146]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
D
-
Y
F
P
E
----
S
S
-
I
S
V
I
H
S
A
K
D
W
Q
E
A
I
D
F
S
M
V
S
L
L
D
K
N
Y
I
----
S
E
N
Y
I
Q
A
I
K
D
S
-
T
I
N
N
G
-------------
P
Y
Y
-
I
-
L
A
---
P
G
V
--------------------------------------------------
A
M
P
H
---------
A
R
P
E
---
C
G
A
L
K
T
G
M
S
L
T
L
L
E
Q
G
V
Y
F
P
G
N
D
-------
E
P
I
K
L
L
I
G
L
S
A
A
D
A
--
D
S
H
I
-
G
-
A
I
Q
A
L
S
E
L
L
C
E
E
E
I
L
E
Q
L
L
T
A
S
S
E
K
Q
L
A
D
I
I
S
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
46.57
11%
-26
- C3 -
3T43
-
?
A:
[3-140]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
D
I
I
K
A
L
A
S
P
L
I
N
D
G
M
V
----
V
S
D
F
A
D
H
V
I
T
R
-
E
Q
N
---------------
A
P
T
-
G
-
L
P
VEP
V
G
V
--------------------------------------------------
A
I
P
H
---------
T
D
S
K
---
Y
-
V
R
Q
N
A
I
S
V
G
I
L
A
E
P
V
N
F
E
D
A
G
G
E
PD
P
--
V
P
V
R
V
V
F
M
L
A
L
G
N
W
--
F
D
I
T
-
N
-
V
L
W
W
I
M
D
V
I
Q
D
A
D
F
M
Q
Q
L
L
V
M
N
D
D
-
E
I
Y
Q
S
I
Y
T
R
I
S
E
A
A
G
M
A
G
I
H
F
R
R
H
Y
V
-----
R
H
L
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
44.96
14%
37
- C3 -
2OQT
-
?
A:
[3-151]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
Q
A
L
I
D
N
----
N
S
-
I
R
L
G
L
S
A
D
T
W
Q
E
A
V
R
L
A
V
Q
P
L
I
D
S
K
A
V
T
----
S
A
Y
Y
D
A
I
I
A
S
T
E
K
Y
---------------
G
P
Y
Y
V
-
L
M
---
P
G
M
--------------------------------------------------
A
M
P
H
---------
A
E
A
-L--
G
-
V
N
R
N
A
F
A
L
I
T
L
T
K
P
V
T
F
S
D
--
G
------
K
E
V
S
V
L
L
T
L
A
A
T
D
P
--
S
I
H
T
-
T
V
A
I
P
Q
I
V
A
L
F
E
L
D
N
A
I
E
R
L
V
A
C
Q
S
P
K
E
V
L
E
M
V
E
E
S
K
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
42.70
29%
47
- C3 -
4GQX
-
?
A:
[80-154]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
K
---
G
-
L
K
H
P
L
A
A
F
V
R
L
A
E
P
I
P
F
----
E
A
--
P
DG
Q
P
V
S
L
L
I
F
L
L
V
P
E
Q
A
T
Q
A
H
L
-
E
-
I
L
S
E
I
A
Q
L
L
S
D
R
D
T
R
E
R
L
H
T
E
P
D
R
D
E
L
H
R
L
L
T
Q
W
Q
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
41.91
29%
53
- C3 -
3URR
3
?
A:
[70-144]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
K
---
G
-
L
K
H
P
L
A
A
F
V
R
L
A
E
P
I
P
F
----
E
A
--
P
DG
Q
P
V
S
L
L
I
F
L
L
V
P
E
Q
A
T
Q
A
H
L
-
E
-
I
L
S
E
I
A
Q
L
L
S
D
R
D
T
R
E
R
L
H
T
E
P
D
R
D
E
L
H
R
L
L
T
Q
W
Q
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
37.92
10%
55
- C2 -
3WUQ
-
A:
[3-265]
--------
T
V
D
Q
V
E
E
L
R
R
D
L
R
I
K
S
Q
E
L
E
V
K
N
A
A
A
N
D
K
L
K
K
M
V
K
D
Q
Q
E
A
E
K
K
K
V
M
S
Q
E
I
Q
E
Q
L
H
K
Q
Q
E
V
I
A
D
K
Q
M
S
V
K
E
D
L
D
K
V
E
P
A
V
I
E
A
Q
N
A
V
K
S
I
K
K
Q
H
L
V
E
V
R
S
M
A
N
P
-
P
A
A
V
K
L
A
L
E
S
I
C
L
-
L
-
L
-
G
E
S
T
T
D
W
K
Q
I
R
S
I
I
M
R
E
N
F
I
P
T
I
V
N
F
S
---
A
E
E
I
S
D
A
I
R
E
K
M
K
K
-
N
Y
M
S
NPSY
N
Y
-
E
I
V
N
R
A
S
L
A
C
G
P
M
V
K
W
A
I
A
Q
L
N
Y
A
D
M
L
K
R
V
E
P
L
R
N
E
L
Q
K
L
E
D
-
D
A
K
D
N
Q
-
Q
K
A
N
E
V
E
Q
M
I
R
D
L
E
-
A
-
S
I
---
A
R
Y
K
E
E
Y
A
V
L
I
S
E
A
Q
A
I
K
A
-
D
L
A
A
V
E
A
--
K
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
31.22
11%
1
- C3 -
3QE7
2
URAA_ECOLI
A:
[226-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
KDLL
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
-
G
S
T
P
N
T
T
Y
G
E
N
--
I
G
V
--------
M
A
I
T
R
V
---
Y
S
T
-
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
----
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
29.66
17%
324
- C3 -
2KK7
-
VATE_METJA
A:
[1-52]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
V
K
L
M
G
V
D
K
I
K
S
K
I
L
D
D
A
K
A
E
A
N
K
I
I
S
E
A
E
A
E
K
A
K
I
L
E
K
-
A
K
E
E
A
E
-
K
R
K
A
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
26.23
19%
750
- C3 -
4MQV
-
SMAL1_HUMAN
B:
[1-26]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
K
K
I
E
E
N
R
Q
K
A
L
A
R
R
A
E
K
L
L
A
------------------------------------------------------------