@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S52A2_HUMAN: (2015-12-11 )
MAAPTPARPVLTHLLVALFGMGSWAAVNGIWVELPVVVKELPEGWSLPSYVSVLVALGNLGLLVVTLWRRLAPGKDEQVPIRVVQVLGMVGTALLASLWHHVAPVAGQLHSVAFLALAFVLALACCASNVTFLPFLSHLPPRFLRSFFLGQGLSALLPCVLALVQGVGRLECPPAPINGTPGPPLDFLERFPASTFFWALTALLVASAAAFQGLLLLLPPPPSVPTGELGSGLQVGAPGAEEEVEESSPLQEPPSQAAGTTPGPDPKAYQLLSARSACLLGLLAATNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSAANPLACFLAMGVLCRSLAGLGGLSLLGVFCGGYLMALAVLSPCPPLVGTSAGVVLVVLSWVLCLGVFSYVKVAASSLLHGGGRPALLAAGVAIQVGSLLGAVAMFPPTSIYHVFHSRKDCADPCDS
Atome Classification :
(16 SA)
-.........10........20........30........40........50....---....60........70........80........90--.........100.---......110.......120.......130.----......140.-----......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260..-......----270--........280.......290.......300.......310.....---..320------........-------.330..-------.....340..-----....-.350.......360.......370.......380.......390..--.....400....-...410.......420-........430.......440-----.....----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MAAPTP
A
R
P
V
L
T
H
L
L
V
A
L
FGMGS
W
A
A
V
N
G
I
W
V
E
L
P
V
V
V
K
ELPEGWS
L
P
S
Y
V
S
V
L
V
---
A
LGN
L
G
L
L
V
V
T
L
W
R
R
LAPGKDEQ
V
P
I
R
V
V
Q
V
L
G
M
V
---
G
T
A
L
L
A
S
L
W
H
H
V
A
---
P
V
A
G
Q
L
H
S
V
A
F
L
A
L
A
F
V
L
A
L
A
C
C
ASNV
T
F
L
----
P
F
L
SHL
P
P
R
F
-----
L
R
S
F
F
L
GQ
G
L
S
A
L
L
P
C
V
L
A
L
V
Q
G
VGRLECPPAPINGTPGP
P
L
D
F
L
E
RFPA
S
T
F
F
W
A
L
T
A
L
L
V
A
S
A
A
A
F
Q
G
L
L
L
L
LPPPPSVPTGELGSGLQVGAPG
A
E
E
E
V
EESSPLQEPPSQAAGT-TPG-PD
P
K
A
Y
----
Q
L
---
L
S
A
R
S
A
C
L
L
G
L
L
A
A
T
N
A
L
T
N
G
V
L
P
A
V
Q
SFSCLP
Y
G
R
L
A
Y
H
L
A
V
V
LG---SAA--------
N
P
L
A
C
F
L
A
-------
M
G
V
L
C
R
-------
S
L
A
GL
G
G
L
S
L
-----
L
G
V
F
-
C
G
G
Y
L
M
A
L
A
V
LSPCPPLVGTS
A
G
V
V
L
V
V
L
S
W
V
L
C
L
G
V
F
S
Y
V
K
V
A
A
S
--
S
L
LHGGG
R
P
A
L
L
-AA
G
V
A
I
Q
V
G
S
L
L
G
A
V
--AMFP
P
T
S
I
Y
H
V
F
HSRKDCA-------DPCDS----------------
13
Fugue
78.20
17%
-137
- C6 -
4XGC
-
?
D:
[5-457]
-
D
R
E
L
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F
L
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R
-----
D
Y
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G
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A
D
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P
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H
L
D
G
N
L
HTD
D
R
V
A
L
K
S
I
T
V
Q
M
Q
LEN
A
A
D
G
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V
F
G
S
F
A
E
N
L
A
F
L
L
Q
C
L
K
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K
S
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I
F
I
L
E
E
F
D
L
F
C
A
H
H
N
Q
T
L
-----
L
Y
N
L
F
D
V
S
Q
S
A
Q
A
P
I
C
V
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G
V
T
---
C
R
L
D
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I
E
L
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-------
E
K
R
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K
S
R
F
S
H
R
Q
V
F
L
F
P
S
L
R
R
F
E
D
Y
V
D
L
C
R
D
L
L
S
L
P
T
----------------
G
N
S
L
L
L
A
A
E
K
I
Y
N
L
Q
N
I
Q
S
G
A
L
Y
F
-
S
R
N
H
F
D
P
G
E
Y
G
F
S
P
R
L
---
R
D
A
W
N
K
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L
A
T
Q
Q
A
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S
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Q
A
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D
F
D
I
S
E
A
Y
L
K
N
F
L
F
R
L
V
A
H
L
----
R
P
Q
--------
S
P
H
I
T
A
E
K
-------
M
A
A
V
G
S
-------
Q
F
E
G
D
D
K
I
E
L
-----
L
C
G
L
S
V
L
E
L
C
L
I
I
A
I
K
H
H
S
Q
I
Y
D
R
D
S
F
N
F
E
I
I
Y
A
R
F
S
K
F
A
K
V
--------
S
--
T
T
M
Q
A
V
E
R
S
I
V
L
-
K
A
F
E
H
L
R
I
A
E
L
I
M
P
L
--
T
K
V
Q
K
E
F
E
M
H
K
L
A
L
T
Y
S
Q
I
-------
H
H
C
M
Q
R
YQALPT
E
V
A
Q
W
A
QSS
12
Fugue
77.74
16%
-89
- C6 -
4BIJ
-
TERL_BPT7
A:
[1-476]
-
M
S
T
Q
S
N
R
N
A
L
V
V
A
Q
L
K
G
D
F
V
----
A
F
L
F
V
L
W
K
A
L
-----
N
L
P
V
P
T
K
C
Q
I
D
M
A
K
V
L
---
A
N
G
D
N
K
K
F
I
L
Q
A
F
R
G
I
G
---------
K
S
F
I
T
C
A
F
V
---
V
W
S
L
W
R
D
P
Q
L
K
I
L
---
I
V
S
A
S
K
E
R
A
D
A
N
S
I
F
I
K
N
I
I
-------
D
L
L
----
P
F
L
S
E
L
K
P
R
P
GQRDS
V
I
S
F
D
V
G
P
A
N
P
D
H
S
P
S
V
K
S
-
V
G
I
T
G
Q
L
T
G
S
R
A
D
I
I
I
A
D
D
V
E
I
------
P
S
N
S
A
T
M
G
A
R
E
K
L
W
T
L
V
Q
E
F
A
A
L
L
K
P
L
P
S
S
R
V
I
Y
L
G
T
P
Q
T
E
M
T
L
Y
K
E
L
E
D
N
R
G
Y
T
T
I
I
W
P
A
L
Y
P
R
T
R
E
E
-
N
L
Y
-
Y
S
Q
R
L
A
----
M
L
---
R
A
E
Y
D
E
N
P
E
A
L
A
G
T
P
T
D
P
V
R
F
D
R
D
D
L
R
E
R
E
-
L
E
Y
G
K
A
G
F
T
L
Q
F
M
L
N
P
NL
S
D
A
EKYPLRLR
D
A
I
V
A
A
L
D
L
E
KAM
H
Y
Q
W
L
P
N
R
QNIIE
D
L
P
N
V
G
L
K
G
D
D
L
HTYHD
C
S
N
N
-
S
G
Q
Y
Q
Q
K
I
L
V
I
D
P
S
G
R
G
K
D
E
T
G
Y
A
V
L
Y
T
L
N
G
Y
I
Y
L
M
E
A
G
G
F
R
D
G
Y
S
DK
T
L
E
L
L
A
K
K
A
K
Q
W
-
G
V
Q
T
V
V
Y
E
S
N
F
G
D
G
M
FG
K
V
F
S
P
I
L
L
K
H
H
N
C
A
M
E
E
I
R
A
R
G
MKEM
R
I
C
D
T
L
E
P
V
M
Q
T
H
R
LVIRDEV
16
Fugue
77.13
19%
-116
- C6 -
4CR2
-
PSA5_YEAST (first)
S:
[126-478]
K
T
I
E
V
T
A
E
I
N
C
F
M
H
L
L
V
Q
L
F
L
W
D
S
K
E
L
E
Q
L
V
E
F
N
R
K
V
V
I
P
N
L
L
C
Y
Y
N
L
R
S
-------------
L
N
L
I
N
A
K
L
W
F
Y
I
Y
L
S
H
E
T
L
A
R
S
S
E
E
I
N
S
D
N
Q
---
N
I
I
L
R
S
T
M
M
K
F
L
K
---
I
-
A
S
L
K
H
D
N
E
T
K
A
M
L
I
N
L
I
L
R
D
F
L
N
N
-----------------------------
G
E
--------
V
D
S
A
S
D
F
I
S
K
L
E
Y
P
H
T
D
V
S
----
S
S
L
E
A
R
Y
F
F
Y
L
S
K
I
N
A
I
Q
L
D
Y
S
T
A
N
E
Y
I
I
A
A
I
R
K
A
P
H
N
S
K
S
L
G
F
L
Q
Q
S
N
K
L
H
C
C
I
Q
L
L
M
G
D
I
P
E
L
S
F
F
H
Q
-----------------------------
S
N
M
Q
K
S
L
L
P
Y
Y
H
L
T
K
A
V
K
L
G
D
L
K
K
F
T
S
T
I
T
K
-------
Y
K
Q
L
L
L
K
---
D
D
T
--------
Y
Q
L
C
V
R
L
R
-------
S
N
V
I
K
T
-------
G
I
R
I
I
---
S
L
-----------------------------
T
Y
K
K
I
S
L
R
D
I
C
L
K
L
N
L
D
S
E
Q
T
V
E
Y
M
V
S
--
R
A
I
R
D
G
V
I
E
A
K
I
N
H
E
D
G
F
I
E
T
T
E
L
L
N
-----
I
Y
D
S
E
D
P
Q
Q
V
F
D
E
R
I
K
F
A
-------
N
Q
L
H
D
E
Y
L
V
S-----------
14
Fugue
38.57
17%
66
- C6 -
1ZW0
-
?
A:
[1-65]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
Q
L
E
E
Q
L
H
N
V
E
T
V
R
S
I
T
M
Q
L
E
M
A
L
T
K
L
K
K
D
M
M
R
G
-
G
D
A
K
Q
Y
----
Q
V
---
W
Q
R
E
S
K
A
L
E
S
A
I
A
I
I
H
Y
V
A
G
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
36.24
36%
135
* C6 *
3PZD
-
B:
[1-36]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
K
P
T
-
E
D
P
A
S
V
----
Y
E
QDD
L
S
E
Q
M
A
S
L
E
G
L
M
K
Q
L
N
A
I
T
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
34.84
61%
304
- C3 -
3ZJ0
-
AT_OCEGH
A:
[90-107]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
L
R
A
G
L
T
-
D
P
G
-
P
D
P
A
A
W
----
Q
G
---
S
D
W
A
R
D
A
I
H
R
P
P
A
L
P
P
I
D
L
A
A
Y
P
A
H
G
H
I
D
L
L
P
R
A
Q
G
R
G
V
G
S
R
A
M
D
H
---
L
E
A
--------
A
L
A
A
A
G
A
P
-------
G
M
H
L
Q
V
-------
S
P
E
N
P
R
A
L
G
F
-----
Y
E
H
R
-
G
F
R
E
L
C
R
S
E
D
E
V
V
V
G
R
R
L
L
----------------------------------------------------------------------------------------------------------
19
Fugue
34.08
15%
182
- C6 -
2C1M
-
NUP50_MOUSE
B:
[1-46]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
R
V
A
E
K
E
L
T
D
R
N
W
D
E
E
D
E
V
E
E
M
G
T
-
F
S
V
-
A
S
E
E
V
M
----
K
N
---
R
A
V
K
K
A
K
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
32.46
9%
186
- C6 -
2KHK
-
ATPF_ECOLI
A:
[1-53]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
A
I
E
K
R
Q
K
E
I
A
D
G
L
A
S
A
E
R
A
H
K
D
L
D
L
A
K
A
S
A
T
D
Q
L
K
K
A
K
A
E
-
A
Q
V
-
I
I
E
Q
A
N
----
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
28.47
30%
361
- C6 -
2XZE
-
CHMP3_HUMAN
Q:
[18-40]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
D
E
E
E
E
E
E
A
L
E
A
M
Q
S
R
L
A
T
L
-
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
26.00
29%
288
- C4 -
1SLU
-
?
A:
[102-125]
--------------------
G
D
A
G
M
L
R
Y
N
S
---
K
L
P
I
V
V
-
Y
T
P
D
N
V
D
V
K
Y
R
V
W
K
A
E
---
E
K
I
D
N
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
24.88
21%
449
- C7 -
3BYB
-
VKT1_PSETT
A:
[45-58]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
F
I
T
K
E
E
C
E
-------
S
T
C
A
-----------------
4
HHSearch
23.48
57%
1705
- C1 -
3LE4
-
DGCR8_HUMAN
A:
[302-308]
----------------------------------------
P
L
P
D
G
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
HHSearch
23.14
53%
713
- C5 -
2RFE
-
ERRFI_HUMAN
E:
[18-32]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
G
V
M
P
P
T
Q
S
F
A
P
D
P
K
Y
V
S
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
22.77
8%
-8
* C7 *
3WU2
-
PSBT_THEVL
T:
[7-29]
------------------------------------------------------------------------------------
T
Y
V
F
I
F
A
C
I
I
---
A
L
F
F
F
A
I
F
F
R
E
P
P
---
R
I
T
A
N
L
W
E
R
F
C
N
W
V
T
S
T
D
N
R
L
Y
V
G
W
F
G
V
I
M
----
I
P
T
L
L
A
A
T
I
C
-----
F
V
I
A
F
I
A
A
P
P
V
D
I
D
G
I
R
E
P
V
S
G
S
L
L
Y
G
N
N
I
I
T
G
A
V
V
P
S
S
N
A
I
G
L
H
F
Y
P
I
W
E
A
A
S
L
D
E
W
L
Y
N
G
G
P
Y
Q
L
I
I
F
H
F
L
L
G
A
S
C
Y
M
G
R
Q
W
E
L
S
Y
R
L
G
M
R
P
W
I
C
V
A
Y
S
A
P
L
A
S
A
F
A
V
F
L
I
Y
P
I
G
-
Q
G
S
-
F
S
D
G
M
P
----
L
G
---
I
S
G
T
F
N
F
M
I
V
F
Q
A
E
H
N
I
L
M
H
P
F
H
Q
L
G
V
A
G
V
F
G
G
A
L
F
C
A
M
H
G
S
L
V
T
S
---
S
L
I
--------
R
E
T
T
E
T
E
S
-------
A
N
Y
G
Y
K
-------
F
G
Q
E
E
E
T
Y
N
I
-----
V
A
A
H
-
G
Y
F
G
R
L
I
F
Q
Y
A
S
F
N
N
S
R
S
L
H
F
F
L
A
A
W
P
V
V
G
V
W
F
A
A
L
G
I
S
T
M
A
F
N
L
N
--
G
F
N
F
N
H
S
V
I
D
A
K
-
G
N
V
I
N
T
W
A
D
I
I
N
R
A
N
--
L
G
M
E
V
M
H
E
R
N
A
H
N
F
P
L
D
L
A
----------------------------
7
HHSearch
16.98
57%
1744
- C2 -
2MDW
-
?
A:
[2-B1]
-----------------------------------------
L
P
P
G
W
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
16.28
14%
465
- C7 -
1OEF
-
A:
[265-278]
---------------------------------------------------------------------------------------------------------------------------------------------
F
E
----
P
L
V
E
D
M
Q
R
Q
W
-----
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------