@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S7A13_HUMAN: (2015-12-11 )
MDRGEKIQLKRVFGYWWGTSFLLINIIGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTSTLCSAEISISFPCSGAQYYFLKRYFGSTVAFLNLWTSLFLGSGVVAGQALLLAEYSIQPFFPSCSVPKLPKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVERFQNAFDAELPDISHLIQAIFQGYFAYSGGACFTLIAGELKKPRTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAWIMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTLNSHSSPFTAVLLLVTLGSLAIILTSLIDLINYIFFTGSLWSILLMIGILRRRYQEPNLSIPYKVFLSFPLATIVIDVGLVVIPLVKSPNVHYVYVLLLVLSGLLFYIPLIHFKIRLAWFEKMTCYLQLLFNICLPDVSEE
Atome Classification :
(20 SA)
----------.........10.---.......20........30...-.....40.....--...-50.--.....----..60........70...-.....80........90.-....---.--..-----100..--..-...110.......120......-.130...-.-....140.......-150-.......160---------------.......170.......-----180......--.190-..---..----------.--..200-.---.....---..210..-.....----.220..----------.--..-.-.230.-......240.......250.......---260......---------------.270.------.--....------..-.280..-.-....290-----.....-------------------------..300.......310...----...-.320.......330........340.-.....----.350..----.----.--------..-..360---.....--------...370--......--------...380.......390.......-------400......--.410.......420.......430---.------........440..--...------------------..450.......460.......470-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MDRG
E
K
I
Q
L
K
R
V
---
F
G
Y
WWGT
S
F
L
L
I
N
IIGA
G
I
F
VS-P
K
G
V
L
A
Y
S
C
M
N
V
--
G
V
S
-
L
C
V
--
W
A
G
C
A
----
I
L
A
M
T
S
T
LC
S
A
E
I
S
I
S
F-PCSG
A
Q
Y
Y
F
L
K
R
YFG
S
T
V
-
A
F
L
N
---
L
--
W
T
-----
S
L
F
LG--S
G
-
V
V
AG
Q
A
L
L
L
A
E
YSIQPFFPSCS-VP-KL
P
K
-
K
-
C
L
A
L
A
M
L
W
I
V
G
I
L
T-SRG-V
K
E
V
T
W
L
Q
I
A
---------------
S
S
V
L
K
V
S
I
L
S
F
I
S
L
T
G
V
-----
V
F
L
IRGKKE--
N
V
E
R
-
F
Q
---
N
A----------F--DAEL--P---
D
I
S
H
L
---
I
Q
A
I
-
F
Q
-
G
Y
FAY----SG
G
A
C
F
----------
T
--
L
I
-
A
-GELKK-PRTT
I
P
K
C
I
F
T
A
L
P
L
V
T
V
V
Y
L
L
V
N
I
S
---
Y
L
T
V
L
T
P
R
E
---------------IL--S------S--D
A
V
A
------
I
T
-WADRAF-
P
-
S
L
A
W
I
M
P
-----
F
A
I
S
T
-------------------------
S
L
F
S
N
L
L
I
S
I
F
KSSR
P
I
Y
----
L
AS-QEGQ
L
P
L
L
F
N
T
L
N-SHS
S
P
F
T
A
V
L
L
L
-
V
T
L
G
S
----
L
A
I
-
I
L
----
T
----
S
--------
L
I
-
D
L
I
N
----
Y
I
F
FT--------
G
S
L
W
----
S
I
L
L
M
I
--------
G
I
L
R
R
R
YQEPNLSI
P
Y
K
V
F
LSF
P
-------
L
A
T
I
V
I
D
V
G
--
L
V
V
I
P
LVKSPN
V
H
Y
V
Y
V
L
L
L
V
L
-----
S
------
G
L
L
F
Y
I
P
L
I
H
F
K
I
--
R
L
A
------------------
W
F
E
K
M
T
C
Y
L
Q
L
L
F
N
ICLPDVSEE-------------------------
27
Fugue
91.55
17%
-132
- C3 -
4US3
11
?
A:
[10-450]
----GREQWA
S
R
L
G
F
I
L
A
A
M
G
S
A
VG
L
G
N
I
W
R
F
S
Y
V
T
G
E
N
G
G
A
A
F
L
L
V
-
Y
L
G
F
I
A
L
I
G
I
P
I
--
V
L
A
-
E
F
T
--
I
G
R
R
A
QSD
A
V
G
S
F
E
K
L
A
P
G
K
P
W
K
V
A
G
-
L
M
G
V
A
A
G
F
L
I
L
S
F
Y
G
V
I
A
-
G
W
I
L
---
F
--
Y
L
-----
F
N
Y
I
T
--
G
Q
-
L
W
S
A
P
A
E
G
F
G
G
F
-
F
E
G
F
I
A
N
P
T
-
L
P
-
L
F
W
Q
-
A
-
L
F
M
I
A
T
I
W
I
V
A
I
G
V
-
K
K
G
-
I
E
R
S
N
K
I
L
M
P
---------------
L
L
G
V
L
L
I
A
L
A
I
Y
S
L
T
----------
L
G
G
A
K
E
--
G
L
A
F
-
L
F
---
S
P
----------
D
--
W
S
A
L
--
K
---
D
P
G
V
Y
---
L
A
A
I
-
S
Q
-
A
F
F
T
L
----
S
L
G
-----------------------------------------------
M
G
A
L
I
T
---
Y
G
S
Y
V
S
K
D
S
---------------
R
L
--
P
------
G
--
A
A
V
S
------
V
A
-
G
L
D
T
A
F
-
A
-
I
I
A
G
I
M
I
-----
F
P
A
V
F
-------------------------
A
L
G
L
S
------
P
S
G
G
P
G
L
----
V
F
V
-
V
---
L
P
D
I
F
D
S
I
R
-
L
--
G
P
I
V
G
I
A
F
F
-
I
L
L
G
A
----
A
A
L
S
S
A
----
V
----
S
--------
L
L
-
E
V
P
V
----
A
Y
F
M
R
--------
K
F
D
W
S
R
K
Q
A
A
I
T
L
G
--------
V
I
I
T
L
L
G
I
P
S
S
L
S
F
G
V
L
G
E
V
T
I
I
-------
P
G
L
N
I
F
D
S
V
--
D
F
I
A
S
S
V
F
L
P
L
G
G
M
I
I
A
L
F
I
G
W
GWK
T
-
S
------
D
A
L
A
E
S
D
L
T
D
S
V
W
--
G
K
L
------------------
W
I
L
S
L
R
F
I
A
P
I
A
I
L
I
V
F
L
S
A
F
---------------------------
20
Fugue
88.43
16%
-147
- C3 -
3GIA
7
Y609_METJA
A:
[3-435]
-----------------
L
K
N
K
K
---
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
-----
I
F
G
V
G
A
K
I
A
--
G
R
N
-
L
P
E
T
-
F
I
L
S
G
----
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
-
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
-
I
T
G
A
---
L
--
S
I
-----
L
L
W
M
---
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
-
I
N
-
T
F
N
I
-
A
-
I
T
E
I
G
I
V
A
F
F
T
A
L
N
-
F
F
G
-
S
K
A
V
G
R
A
E
F
F
---------------
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
-----
I
T
I
---
H
P
S
--
Y
V
I
P
-
D
L
---
A
-----------------
P
--
S
---
A
V
S
G
M
---
I
F
A
S
-
A
I
-
F
F
L
S
Y
----
M
G
F
G
V
I
----------
T
--
N
A
-
S
-
E
H
I
E
N
-
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
E
---------------
L
I
K
A
S
------
E
--
N
A
L
A
------
V
A
-
A
K
P
F
L
G
-
N
-
L
G
F
L
L
I
S
-----
I
G
A
L
F
-------------------------
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
-
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
-
L
G
V
L
F
----
A
L
L
-
F
N
----
M
----
E
--------
G
V
-
A
S
I
T
----
S
A
V
F
M
--------
V
I
Y
L
----
F
V
I
L
S
H
--------
Y
I
L
I
D
E
V
-------
G
G
R
K
E
I
V
I
F
-------
S
F
I
V
V
L
G
V
F
--
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
-----
I
------
G
V
L
I
F
E
I
I
Y
R
K
V
T
--
K
R
T
------------------
F
S
N
N
M
Y
--------------
V
K
S
-------------------------
13
HHSearch
87.62
15%
-131
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-433]
-------------------
A
H
K
---
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
S
T
-
G
-----
G
I
A
-
I
Y
G
--
W
L
V
T
I
----
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
-
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
---
N
--
V
L
-----
Y
W
L
A
C
--
W
I
-
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
---
K
D
-
P
W
V
L
-
T
-
I
T
C
V
V
V
L
W
I
F
V
L
L
N
-
I
V
G
-
P
K
M
I
T
R
V
Q
A
V
---------------
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
-----
F
W
F
R
G
E
--------
T
-
Y
M
---
A
---------------------------
A
I
---
Q
S
T
L
-
N
V
-
T
L
W
S
F
----
I
G
V
E
S
A
----------
S
--
V
A
-
A
-
G
V
V
K
N
-
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
P
N
A
A
---------------
L
R
--
V
------
S
--
A
S
P
F
------
G
D
-
A
A
R
M
A
L
-
G
D
T
A
G
A
I
V
S
-----
F
C
A
A
A
-------------------------
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
----
A
A
A
-
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
-
G
I
L
M
T
----
I
-
F
-
Q
L
SSIS
P
NATK
E
--------
F
G
-
L
V
S
S
----
V
S
V
I
F
--------
T
L
V
P
----
Y
L
Y
T
C
A
--------
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
--
V
T
-------
T
I
A
F
L
Y
C
I
W
--
A
V
V
---
G
S
G
A
K
E
V
-
M
W
S
F
V
T
L
M
-----
V
------
I
T
A
M
Y
A
L
N
Y
N
R
L
H
--
K
N
P
------------------
Y
P
L
D
A
-------------------------------------------
22
Fugue
85.67
13%
-128
* C3 *
4DJK
-
GADC_ECOLI
A:
[12-501]
------------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
-
V
Y
E
Y
P
T
F
A
T
S
G
F
--
S
L
V
-
F
F
L
--
L
L
G
G
I
----
L
W
F
I
P
V
G
L
C
A
A
E
M
A
T
V
D
---
G
W
G
V
F
A
W
V
S
N
T
L
G
P
R
W
-
G
F
A
A
---
I
--
S
F
-----
G
Y
L
Q
I
--
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
-
E
D
-
P
I
T
K
-
T
-
I
A
A
L
I
I
L
W
A
L
A
L
T
Q
-
F
G
G
-
T
K
Y
T
A
R
I
A
K
V
---------------
G
F
F
A
-----------
G
I
-----
L
L
P
A
F
I
L
I
A
--
L
A
A
I
-
Y
L
---
H
T
----------
F
--
F
P
D
F
--
S
---
K
V
G
T
L
---
V
V
-
F
-
V
A
-
F
I
L
S
Y
----
M
G
V
E
A
S
----------
A
--
T
H
-
V
-
N
E
M
S
N
-
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
---
I
A
M
V
I
P
G
N
E
INLSA
G
---------
V
M
--
Q
------
T
--
F
T
V
L
------
M
S
-
H
V
A
P
E
I
-
E
-
W
T
V
R
V
I
S
-----
A
L
L
L
L
-------------------------
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
----
V
T
A
-
Q
K
N
L
L
P
A
A
F
A
K
M
N
-
K
N
G
V
P
V
T
L
V
I
S
Q
-
L
V
I
T
S
----
I
A
L
-
I
I
----
L
----
T
--------
N
T
G
G
G
N
N
----
M
S
F
L
I
--------
A
L
A
L
----
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
-------
V
K
L
V
V
A
I
V
G
--
L
L
T
S
I
M
A
F
I
V
S
----
F
L
P
P
D
N
I
-----
Q
------
G
D
S
T
D
M
Y
V
E
L
L
V
V
--
S
F
L
------------------
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
-------------------------
12
HHSearch
84.36
14%
-127
- C3 -
3GIA
7
Y609_METJA
A:
[3-430]
-----------------
L
K
N
K
K
---
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
-
F
G
V
G
A
K
I
A
G
-----
R
N
L
-
P
E
T
--
F
I
L
S
G
----
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
-
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
---
S
--
I
L
-----
L
W
M
S
Y
--
V
I
-
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
---
I
N
-
T
F
N
I
-
A
-
I
T
E
I
G
I
V
A
F
F
T
A
L
N
-
F
F
G
-
S
K
A
V
G
R
A
E
F
F
---------------
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
-----
I
T
I
H
P
--------
S
Y
-
V
I
---
P
D
----------
L
--
A
--
P
--
S
---
A
V
S
G
M
---
I
F
A
S
-
A
I
-
F
F
L
S
Y
----
M
G
F
G
V
I
----------
T
--
N
A
-
S
-
E
H
I
E
N
-
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
E
---------------
L
I
--
K
A
-----
S
--
E
N
A
L
------
A
V
-
A
A
K
P
F
L
-
G
N
L
G
F
L
L
I
S
-----
I
G
A
L
F
-------------------------
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
-
K
D
G
E
L
P
E
F
F
E
R
K
V
-
W
F
K
S
T
-
E
G
L
Y
I
T
-
S
A
L
G
V
----
L
-
F
-
A
L
----
L
F---
N
--------
M
E
-
G
V
A
S
----
I
T
S
A
V
--------
F
M
V
I
----
Y
L
F
V
I
L
--------
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
-
I
V
---
I
F
S
-------
F
I
V
V
L
G
V
F
L
--
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
-
F
Y
G
I
I
A
T
F
-----
I
------
G
V
L
I
F
E
I
I
Y
R
K
V
T
--
K
R
T
------------------
F
S
N
N
M
Y
V
K
S
---------------------------------------
1
PsiBlast_PDB
78.60
22%
-116
- C3 -
3NCY
-
ADIC_SALTY
A:
[22-333]
-------------------------------------
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
A
T
G
------
G
I
A
-
I
Y
G
--
W
L
V
T
I
----
I
G
A
L
A
L
S
M
V
Y
A
K
M
S
S
L
D
-
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
--
W
L
-----
A
C
W
I
G
N
I
A
M
-
V
V
I
G
V
G
Y
L
------
S
Y
F
F
P
I
L
K
-
D
P
L
V
L
T
L
-
T
-
C
V
A
V
--
L
W
I
F
V
L
L
N
-
I
V
G
-
P
K
M
I
T
R
V
Q
A
V
---------------
A
T
V
L
A
L
V
P
I
V
G
I
A
V
F
G
W
------
F
W
F
K
G
-------
E
-------------------
W
--
N
V
S
G
--
M
---
N
T
F
G
A
---
I
Q
S
T
-
L
N
V
T
L
W
S
F
----
I
G
V
E
S
A
----------
S
--
V
A
-
A
-
G
V
V
K
N
-
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
-
P
N
A
---------------
A
L
--
R
VSASPF
G
--
D
A
A
R
------
M
A
-
L
G
D
T
A
------
G
A
I
V
S
-----
F
C
A
A
A
-------------------------
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
----
A
A
A
-
D
D
G
L
F
P
P
I
F
A
R
------
T
P
V
A
G
L
L
I
V
-
G
V
L
M
T
----
I
F
Q
-
F
S
----
S
----
M
--------
S
P
-
N
A
A
K
----
E
F
G
L
V
--------
S
S
V
S
----
V
I
F
T
L
V
--------
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
L
-------
Y
L
L
I
T
F
V
A
F
--
V
Y
C
I
W
A
V
I
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
------
V
I
T
A
L
Y
A
L
N
Y
N
R
I
--
H
K
N
------------------
P
Y
P
L
D
A
P
-----------------------------------------
3
PsiBlast_PDB
77.38
21%
-121
- C3 -
3LRB
-
ADIC_ECO57
A:
[22-330]
-------------------------------------
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
S
T
G
------
G
I
A
-
I
Y
G
--
W
L
V
T
I
----
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
-
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
--
W
L
-----
A
C
W
I
G
N
I
A
M
-
V
V
I
G
V
G
Y
L
------
S
Y
F
F
P
I
L
K
-
D
P
L
V
L
T
I
-
T
-
C
V
V
V
--
L
W
I
F
V
L
L
N
-
I
V
G
-
P
K
M
I
T
R
V
Q
A
V
---------------
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
------
F
W
F
R
G
-------
E
T
-
Y
M
---
A
A
----------
W
--
N
V
S
G
--
L
---
G
T
F
G
A
---
I
Q
S
T
-
L
N
V
T
L
W
S
F
----
I
G
V
E
S
A
----------
S
--
V
A
-
A
-
G
V
V
K
N
-
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
-
P
N
----------------------------------------------
T
A
------
G
A
I
V
S
-----
F
C
A
A
A
-------------------------
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
----
A
A
A
-
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
-
G
I
L
M
T
----
I
F
Q
-
L
S
----
S
----
I
--------
S
P
-
N
A
T
K
----
E
F
G
L
V
--------
S
S
V
S
----
V
I
F
T
L
V
--------
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
-------
Y
L
A
V
T
T
I
A
F
--
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
------
V
I
T
A
M
Y
A
L
N
Y
N
R
L
--
H
K
N
------------------
P
-----------------------------------------------
2
PsiBlast_PDB
77.30
21%
-118
- C3 -
3OB6
1
ADIC_ECOLI
A:
[22-330]
-------------------------------------
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
S
T
G
------
G
I
A
-
I
Y
G
--
W
L
V
T
I
----
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
-
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
--
W
L
-----
A
C
W
I
G
-------
A
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
-
D
P
L
V
L
T
I
-
T
-
C
V
V
V
--
L
W
I
F
V
L
L
N
-
I
V
G
-
P
K
M
I
T
R
V
Q
A
V
---------------
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
------
F
W
F
R
G
-------
E
T
-
Y
M
---
A
A
----------
W
--
N
V
S
G
--
L
---
G
T
F
G
A
---
I
Q
S
T
-
L
N
V
T
L
W
S
F
----
I
G
V
E
S
A
----------
S
--
V
A
-
A
-
G
V
V
K
N
-
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
-
P
N
A
---------------
A
L
--
R
V
SAS
P
F
G
--
D
A
A
R
------
M
A
-
L
G
D
T
A
------
G
A
I
V
S
-----
F
C
A
A
A
-------------------------
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
----
A
A
A
-
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
-
G
I
L
M
T
----
I
F
Q
-
L
S
----
S
----
I
--------
S
P
-
G
L
V
S
----
S
V
S
V
I
--------
F
T
L
V
----
P
Y
L
Y
T
C
--------
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
-------
I
A
F
L
Y
C
I
W
A
--
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
-----
Y
------
A
L
N
Y
N
R
L
H
K
N
P
Y
P
--
L
D
A
------------------------------------------------------------------
4
PsiBlast_PDB
76.88
21%
-119
- C3 -
3LRC
-
ADIC_ECO57
A:
[22-330]
-------------------------------------
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
S
T
G
------
G
I
A
-
I
Y
G
--
W
L
V
T
I
----
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
-
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
--
W
L
-----
A
C
W
I
G
N
I
A
M
-
V
V
I
G
V
G
Y
L
------
S
Y
F
F
P
I
L
K
-
D
P
L
V
L
T
I
-
T
-
C
V
V
V
--
L
W
I
F
V
L
L
N
-
I
V
G
-
P
K
M
I
T
R
V
Q
A
V
---------------
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
------
F
W
F
R
G
-------
E
T
-
Y
M
---
A
A
----------
W
--
N
V
S
G
--
L
---
G
T
F
G
A
---
I
Q
S
T
-
L
N
V
T
L
W
S
F
----
I
G
V
E
S
A
----------
S
--
V
A
-
A
-
G
V
V
K
N
-
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
-
P
N
----------------------------------------------
T
A
------
G
A
I
V
S
-----
F
C
A
A
A
-------------------------
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
----
A
A
A
-
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
-
G
I
L
M
T
----
I
F
Q
-
L
S
----
S
----
I
--------
S
P
-
N
A
T
K
----
E
F
G
L
V
--------
S
S
V
S
----
V
I
F
T
L
V
--------
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
-------
Y
L
A
V
T
T
I
A
F
--
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
------
V
I
T
A
M
Y
A
L
N
Y
N
R
L
--
H
K
N
------------------
P
-----------------------------------------------
5
PsiBlast_PDB
75.91
21%
-123
- C3 -
3L1L
2
ADIC_ECO57
A:
[23-330]
--------------------------------------
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
S
T
G
------
G
I
A
-
I
Y
G
--
W
L
V
T
I
----
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
-
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
--
W
L
-----
A
C
W
I
G
N
I
A
M
-
V
V
I
G
V
G
Y
L
------
S
Y
F
F
P
I
L
K
-
D
P
W
V
L
T
I
-
T
-
C
V
V
V
--
L
W
I
F
V
L
L
N
-
I
V
G
-
P
K
M
I
T
R
V
Q
A
V
---------------
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
------
F
W
F
R
G
-------
E
T
-
Y
M
---
A
----------------------------
A
---
I
Q
S
T
-
L
N
V
T
L
W
S
F
----
I
G
V
E
S
A
----------
S
--
V
A
-
A
-
G
V
V
K
N
-
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
-
P
N
A
---------------
A
L
--
R
VSASP
F
G
--
D
A
A
R
------
M
A
-
L
G
D
T
A
------
G
A
I
V
S
-----
F
C
A
A
A
-------------------------
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
----
A
A
A
-
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
-
G
I
L
M
T
----
I
F
Q
-
L
S
----
S
----
I
--------
S
P
-
N
A
T
K
----
E
F
G
L
V
--------
S
S
V
S
----
V
I
F
T
L
V
--------
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
-------
Y
L
A
V
T
T
I
A
F
--
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
------
V
I
T
A
M
Y
A
L
N
Y
N
R
L
--
H
K
N
------------------
P
Y
P
L
D
A
------------------------------------------
25
Fugue
65.32
14%
-95
- C3 -
3DH4
1
?
A:
[52-518]
----------
A
G
K
S
L
P
----------
W
W
A
V
G
A
S
L
I
A
A
N
I
-
S
A
E
Q
F
I
-----
G
M
S
G
S
G
Y
S
I
--
G
L
A
-
I
A
S
Y
E
W
M
S
A
I
----
T
L
I
I
V
G
K
Y
F
-
L
P
I
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
-
F
N
K
K
L
-
K
T
I
L
---
A
--
V
F
-----
W
I
S
L
Y
--
I
F
-
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
--------
I
P
L
-
M
-
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
-
I
V
V
W
T
D
V
I
Q
V
F
F
L
V
---------------
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
-----
D
G
W
F
A
G
V
S
K
--
M
V
D
A
-
A
P
---
G
H
FEMILDQSNP
Q
--
Y
M
N
L
--
P
---
G
I
A
V
L
---
I
G
G
L
-
W
V
-
A
N
L
Y
Y
WGFN
Q
Y
I
I
Q
R
----------
T
--
L
A
-
A
-
K
S
V
S
E
-
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
---
Y
V
I
T
S
D
P
Q
L
---------------
M
A
--
S
------
L
--
G
D
I
A
ATNLPS
A
A
-
N
A
D
K
A
Y
-
P
-
W
L
T
Q
F
L
P
-----
V
G
V
K
G
-------------------------
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
----
N
S
T
-
A
T
I
F
T
M
D
I
Y
K
E
Y
I
-
S
P
D
S
G
D
H
K
L
V
N
V
-
G
R
T
A
A
----
V
V
A
-
L
I
----
I
----
A
--------
C
L
-
I
A
P
M
----
L
G
G
I
G
--------
Q
A
F
Q
----
Y
I
Q
E
Y
T
--------
G
-----
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
KTT
S
K
G
A
I
I
G
V
V
A
S
I
P
--
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
-----
L
------
F
T
M
V
V
I
A
F
T
S
L
S
T
--
S
I
N
DDDPKGISVTSSMFVTD
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K-----------------------
26
Fugue
64.12
12%
-149
* C5 *
3E1S
-
RECDL_DEIRA
A:
[193-720]
FTLTEVEGIG
F
L
T
A
D
K
L
W
D
D
P
R
---
R
L
T
A
A
A
V
Y
A
L
Q
L
A
G
T
Q
A
G
H
S
F
L
-
P
R
S
R
A
E
K
G
V
V
H
Y
TR
V
T
P
-
G
Q
A
--
R
L
A
V
E
----
T
A
V
E
L
G
R
L
S
E
D
D
S
P
L
F
A
-
A
A
T
G
E
G
R
I
Y
L
P
H
V
L
R
A
E
K
-
K
L
A
S
---
L
--
I
R
-----
T
L
L
A
T
--
P
P
-
A
D
A
G
N
D
D
W
A
V
P
K
K
-----
A
R
K
G
-
L
S
-
E
E
Q
A
-
S
-
V
L
D
Q
L
A
G
H
R
L
V
V
L
T
G
G
P
G
-
T
G
-------
K
---------------
S
T
T
T
K
A
V
A
D
L
A
E
S
L
G
L
E
-----
V
G
L
C
A
P
T
G
K
--
A
A
R
R
-
L
G
---
E
V
----------
T
--
G
R
T
A
--
S
---
T
V
H
R
L
---
L
G
Y
G
-
P
Q
-
G
F
R
H
N
----
H
L
E
P
A
P
----------
Y
D
L
L
I
-
V
-
D
E
V
S
M
-
M
G
D
A
L
M
L
S
L
L
A
A
V
P
P
G
A
R
V
L
L
V
G
D
T
D
---
Q
L
P
P
V
D
A
G
L
---------------
P
L
--
L
------
A
L
A
Q
A
A
P
------
T
I
-
K
L
T
Q
V
Y
-
R
-
Q
A
A
K
N
P
I
-----
I
Q
A
A
H
-------------------------
G
L
L
H
G
E
A
P
A
W
G
D
K
R
L
N
L
T
----
E
I
E
-
P
D
G
G
A
R
R
V
A
L
M
V
R
-
E
L
G
-
G
P
G
A
V
Q
V
L
-
T
P
M
R
K
GPLG
M
D
H
-
L
N
----
Y
----
H
--------
L
Q
-
A
L
F
N
P
G
E
G
G
V
R
I
A
--------
E
G
E
A
----
R
P
G
D
T
V
--------
V
Q
T
K
N
D
Y
N
N
E
I
F
N
G
T
L
G
M
V
L
K
A
E
-------
G
A
R
L
T
V
D
F
D
GN
V
V
E
L
T
G
A
E
L
F
N
L
Q
L
G
Y
A
L
T
V
H
R
-----
A
QGSEWG
T
V
L
G
V
L
H
E
A
H
M
P
M
LS
R
N
L
------------------
V
Y
T
A
L
T
R
A
R
D
R
F
F
S
A
G
S
A
S
A
W
Q
I
A
A
A
RQ
R
E
A
R
N
T
A
L
L
E
R
I
R
A
H
LEHHH
28
Fugue
59.99
11%
-132
- C5 -
1W36
-
RECD_ECOLI
D:
[2-606]
-----------------
K
L
Q
K
Q
---
L
L
E
A
V
E
H
K
Q
L
R
P
L
D
V
Q
F
A
L
T
V
A
-
G
D
E
H
P
A
V
T
L
A
A
A
--
L
L
S
-
H
D
A
--
G
E
G
H
V
----
C
L
P
L
S
R
L
E
N
N
E
A
S
H
P
L
L
-
A
T
C
V
S
E
I
G
E
L
Q
N
W
E
E
C
L
L
-
A
S
Q
A
---
V
--
S
R
GDEPT
P
M
I
L
C
--
G
D
-
R
L
Y
L
N
R
M
W
C
N
E
R
T
V
A
R
F
F
N
E
V
N
-
H
A
-
I
E
V
D
-
E
-
A
L
L
A
Q
T
L
D
K
L
F
P
V
S
-
D
E
I
-
N
W
Q
K
V
A
A
A
V
A
LTRRISVISGGPGTG
K
T
T
T
V
A
K
L
L
A
A
L
I
Q
M
A
D
GERCR
I
R
L
A
A
P
T
G
K
--
A
A
A
R
-
L
T
---
E
S
----------
L
--
G
K
A
L
--
R
---
Q
L
P
L
T
---
D
E
Q
K
-
K
R
-
I
P
E
D
A
----
S
T
L
H
R
L
LHAGNPLHLD
V
--
L
V
-
V
-
D
E
A
S
M
-
I
D
L
P
M
M
S
R
L
I
D
A
L
P
D
H
A
R
V
I
F
L
G
D
R
D
---
Q
L
A
S
V
E
A
G
A
---------------
V
L
--
G
------
D
IC
A
Y
A
N
------
A
G
-
F
T
A
E
R
A
-
R
-
Q
L
S
R
L
T
G
-----
T
H
V
P
A
GTGTEAASLRDSLCLLQKSYRFGSD
S
G
I
G
Q
L
A
A
A
I
N
R
G
D
K
T
A
V
----
K
T
V
-
F
Q
Q
D
F
T
D
I
E
K
R
L
L
-
Q
S
G
E
D
Y
I
A
M
L
E
E
-
A
L
A
G
Y
----
G
R
Y
-
L
D
----
L
----
L
QARAEPDL
I
I
-
Q
A
F
N
----
E
Y
Q
L
L
CALREGPF
G
V
A
G
----
L
N
E
R
I
E
--------
Q
F
M
Q
Q
K
R
Q
P
S
R
L
P
E
H
E
T
T
W
A
M
T
V
-------
H
K
S
Q
G
S
E
F
D
--
H
A
A
L
I
L
P
S
Q
R
T
P
V
V
T
R
E
L
V
Y
T
A
VTRAR
R
------
R
L
S
L
Y
A
D
E
R
I
L
S
A
--
A
I
A
------------------
T
R
T
E
R
R
S
G
L
A
A
L
F
S
S
R
--------------------------------
29
Fugue
57.55
16%
-72
- C2 -
4DIM
-
?
A:
[3-400]
------------------------------
D
N
K
R
L
L
I
L
G
A
G
R
G
Q
L
G
L
-
Y
K
A
A
K
E
L
G
I
H
T
I
--
A
G
T
M
P
N
A
--
H
K
P
C
L
----
N
L
A
D
---------
E
I
S
Y
M
D
I
S
N
P
D
E
V
E
Q
K
------
V
-
K
D
L
N
---
L
D
G
A
A
-----
T
C
C
L
D
--
T
G
-
I
V
S
L
A
R
I
C
D
K
E
N
L
V
G
L
N
E
E
A
A
I
M
C
G
-
D
K
Y
K
M
K
-----
E
A
F
K
K
Y
N
V
N
T
-
A
R
H
-
F
V
V
R
N
E
N
E
L
K
---------------
N
A
L
E
N
L
K
L
P
V
I
V
K
A
T
D
L
-----
I
Y
I
A
K
K
E
E
E
--
A
I
D
G
-
F
N
E
T
M
N
L
----------
T
--
K
R
D
Y
--
C
---
I
V
E
E
F
---
I
E
G
Y
-
E
F
-
G
A
Q
A
F
----
V
Y
K
N
D
V
----------
L
--
F
V
M
P
H
G
D
E
T
Y
M
S
H
T
A
V
P
V
G
H
Y
V
P
L
D
V
K
D
D
I
I
E
K
T
K
T
E
---
V
K
K
A
I
K
A
L
G
----------------
L
--
N
------
N
--
C
A
V
N
------
V
D
M
I
L
K
----
D
-
N
E
V
Y
I
I
E
-----
L
T
G
R
V
-------------------------
G
--
A
N
C
L
P
E
L
V
E
I
N
Y
G
I
E
Y
Y
K
M
I
A
S
M
A
I
S
E
N
P
L
V
F
W
S
---
Q
K
S
K
E
N
K
A
G
L
A
R
M
I
I
E
T
E
----
K
S
G
-
I
L
----
K
----
E
--------
I
L
-
N
------------------------------------------------
S
N
A
K
D
D
D
I
V
E
I
T
F
F
K
E
E
-------
N
D
E
I
-----------
K
K
F
E
N
S
N
D
C
I
G
Q
I
I
V
K
E
E
-----
T
-------------------------------------------
L
D
K
C
K
D
K
L
D
V
I
I
N
N
I
N
I
I
L
K
---------------------------
14
HHSearch
47.48
13%
-111
- C3 -
3DH4
1
?
A:
[53-355]
-------------------
G
K
S
---
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
-
L
---
A
-
I
-
A
S
Y
--
E
W
M
S
A
----
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
--
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
-
K
T
I
L
---
A
--
V
F
-----
W
I
S
L
Y
I
-
F
V
-
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
---------
I
P
L
-
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
--------
V
V
W
T
D
V
I
---------------
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-----
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
--
A
P
GH--------
F
EM
I
L
D
Q
SN
P
QYM
N
L
P
G
I
AVL
I
G
G
L
W
V
A
-
N
L
Y
Y
W
----
G
F
N
Q
Y
I
----------
I
--
Q
R
-
T
-
L
A
A
K
S
-
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
GDIAATNLPS
A
A
--
N
------
A
--
D
K
A
Y
------
P
W
-
L
T
-
Q
F
L
-
P
V
G
V
K
G
V
V
F
-----
A
A
L
A
A
-------------------------
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
--------
M
D
I
Y
K
E
Y
I
S
P
D
S
G
-
D
H
K
L
V
N
V
G
R
T
A
A
-
V
V
A
L
I
----
I
A
C
-
L
I
----
A
----
P
--------
M
L
-
G
G
I
G
----
Q
A
F
Q
Y
--------
I
Q
E
Y
----
T
G
L
V
S
P
--------
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
K
G
A
I
I
G
-------
V
V
A
S
I
P
F
A
L
--
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
-----
M
------
V
V
I
A
F
T
S
L
S
T
S
I
N
--
D
D
D
------------------
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
-------------------------
8
PsiBlast_PDB
47.13
24%
-83
- C3 -
3GI8
-
Y609_METJA
C:
[194-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
I
-
F
---
F
L
S
Y
----
M
G
F
G
V
I
----------
T
--
N
A
-
S
-
E
H
I
E
N
-
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
E
---------------
L
I
--
K
------
A
--
S
E
N
A
------
L
A
-
V
A
A
K
P
F
-
L
-
G
N
L
G
F
L
L
-----
I
S
I
G
A
LF-----------------------
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
-
K
D
G
E
L
P
E
F
F
E
R
K
V
-
W
F
K
S
T
E
G
L
Y
I
T
S
-
A
L
G
V
L
----
F
A
L
-
L
F
----
N
----
M
--------
E
G
-
V
A
S
I
----
T
S
A
V
F
--------
M
V
I
Y
----
L
F
V
I
L
S
--------
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
-------
G
V
F
L
L
L
L
Y
Y
--
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
-----
E
------
I
I
Y
R
K
V
T
K
R
T
F
S
N
--
N
M
Y
------------------
V
K
S
---------------------------------------------
7
PsiBlast_PDB
45.03
24%
-77
- C3 -
3GIA
3
Y609_METJA
A:
[194-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
I
-
F
---
F
L
S
Y
----
M
G
F
G
V
I
----------
T
--
N
A
-
S
-
E
H
I
E
N
-
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
E
---------------
L
I
--
K
------
A
--
S
E
N
A
------
L
A
-
V
A
A
K
P
F
L
G
-
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
-------------------------
A
M
N
A
----
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
-
K
D
G
E
L
P
E
F
F
E
R
K
V
-
W
F
K
S
T
E
G
L
Y
I
T
S
-
A
L
G
V
L
----
F
A
L
-
L
F
----
N
----
M
--------
E
G
-
V
A
S
I
----
T
S
A
V
F
--------
M
V
I
Y
----
L
F
V
I
L
S
--------
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
-------
G
V
F
L
L
L
L
Y
Y
--
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
-----
E
------
I
I
Y
R
K
V
T
K
R
T
F
S
N
--
N
M
Y
------------------
V
K
S
---------------------------------------------
6
PsiBlast_PDB
44.52
24%
-76
- C3 -
3GI9
-
Y609_METJA
C:
[194-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
I
-
F
---
F
L
S
Y
----
M
G
F
G
V
I
----------
T
--
N
A
-
S
-
E
H
I
E
N
-
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
E
---------------
L
I
--
K
------
A
--
S
E
N
A
------
L
A
-
V
A
A
K
P
F
L
G
-
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
-------------------------
A
M
N
A
----
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
-
K
D
G
E
L
P
E
F
F
E
R
K
V
-
W
F
K
S
T
E
G
L
Y
I
T
S
-
A
L
G
V
L
----
F
A
L
-
L
F
----
N
----
M
--------
E
G
-
V
A
S
I
----
T
S
A
V
F
--------
M
V
I
Y
----
L
F
V
I
L
S
--------
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
-------
G
V
F
L
L
L
L
Y
Y
--
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
-----
E
------
I
I
Y
R
K
V
T
K
R
T
F
S
N
--
N
M
Y
------------------
V
K
S
L
E
S
------------------------------------------
23
Fugue
36.80
21%
225
- C3 -
1LYP
-
?
?:
[1-32]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
K
--
R
L
R
K
-
F
R
---
N
K
----------
I
--
K
E
K
L
--
K
---
K
I
G
Q
K
---
I
Q
G
L
-
L
P
-
K
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
32.24
13%
-105
- C3 -
2JLN
-
?
A:
[21-186]
----------------
R
Y
A
E
R
S
---
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
F
I
A
-
A
G
Q
M
T
--
S
S
F
Q
V
--
W
Q
V
-
I
V
A
--
I
A
A
G
C
----
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
-
G
--
I
N
F
T
V
A
A
R
M
P
F
G
I
R
G
-
S
L
I
P
---
I
--
T
L
-----
K
A
L
L
S
--
L
F
-
W
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
T
G
----
F
T
N
L
-
P
-
L
W
I
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
-
I
T
F
I
R
W
M
N
V
F
---------------
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
-----
D
G
A
D
V
S
L
G
E
--
V
M
S
M
-
G
G
---
E
N
----------
P
--
G
M
P
F
--
S
---
T
A
I
M
I
---
F
V
G
G
-
W
I
-
A
V
V
V
S
----
I
H
D
I
V
K
----------
E
--
C
K
-
V
-
D
P
N
A
S
-
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
---
G
F
I
G
A
A
S
M
V
---------------
L
V
--
G
------
E
--
W
N
P
V
------
I
A
-
I
T
E
V
V
G
-
G
-
V
S
I
P
M
A
I
-----
L
F
Q
V
F
-------------------------
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
A
----
Y
T
L
-
C
S
T
F
P
R
V
F
T
F
K
T
G
-
V
I
V
S
A
V
V
G
L
L
M
M
-
P
W
Q
F
A
----
G
V
L
-
N
T
----
F
----
L
--------
N
L
-
L
A
S
A
----
L
G
P
L
A
--------
G
I
M
I
----
S
D
Y
F
L
V
--------
R
R
R
R
I
S
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
G
V
-------
N
W
V
A
L
A
V
Y
A
--
V
A
L
A
V
S
F
L
T
P
D
L
M
F
V
T
G
L
I
A
A
L
-----
L
------
L
H
I
P
A
M
R
W
V
A
K
T
F
--
P
L
F
------------------
S
E
A
E
S
R
N
E
D
Y
L
R
P
I
G
P
--------------------------------