@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SATT_HUMAN: (2015-12-11 )
MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
Atome Classification :
(36 SA)
.........10........20........30........40........50.....-...60........70........80........90........100.......110.......120.......130.......140-........150.......160.......170.......180.......190.......200.......210.......220.......230.....--------..240-------.--------....--------...250.......260.......270.......280.......290.......300.......310....--...320.---......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440-...------.------...----..450.......460.......470.......480.......490.......500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEKSNETNGYLDSAQAGPAAGPGAPGTAAG
R
A
R
R
C
A
G
F
L
R
R
Q
A
L
V
L
L
T
V
S
G
V
LAGA-
G
L
G
A
A
L
RGLSLS
R
T
Q
V
T
Y
L
AF
P
G
E
M
L
L
R
M
L
R
M
I
I
L
P
L
V
V
C
S
L
VS
G
A
A
SL
D
A
S
C
L
G
RL
G
G
I
A
V
A
Y
F
G
L
T
T
L
S
A
S
A
L
A
V
A
L
A
F
I
IKP--GSGAQTLQSSDLGLEDSGPPPV
P
K
E
T
V
D
S
F
L
D
L
A
R
NLFP
S
N
L
V
V
A
A
F
R
TYAT
D
Y
K
V
V
T
QNSSSGN
V
T
H
EKIPIGTEIE
G
M
N
I
L
G
L
V
L
F
A
L
V
L
G
V
A
L
--------
K
K
LG--------S--------E
G
E
D
--------
L
I
R
F
F
N
SL
N
E
A
T
M
V
L
V
S
W
I
M
W
Y
V
P
V
G
I
M
F
L
VGS
K
I
V
E
M
K
D
I
I
V
L
V
T
S
L
G
K
Y
I
F
A
S
I
L
G
H
V
IHG
G
I
V
L
P
L
I
--
Y
F
V
FTRK---
N
P
F
R
F
L
L
G
L
L
A
P
F
A
T
A
F
A
TCSSSA
T
L
P
S
M
M
K
C
I
EENN
G
V
D
K
R
I
S
R
F
ILPIG
A
T
VNM
D
G
A
A
I
F
Q
C
V
A
A
V
F
I
A
QLN
N
V
E
LNA
G
Q
I
F
T
I
L
V
T
ATASSVGAAGVPAG
G
V
L
T
I
A
I
I
L
E
A
IGL---PTH------D------
L
P
L
----
I
L
A
V
D
W
IVDR
T
T
T
V
V
N
VEG
D
A
L
G
A
G
I
L
H
H
L
N
Q
K
A
TKK
G
E
Q
E
L
A
E
V
K
V
E
AIPNCKSEEETS
P
L
VTHQNPAGPVASAPELESKESVL
41
PsiBlast_CBE
91.73
31%
-133
- C8 -
4KY0
2
?
C:
[22-427]
-------------------------------------------
L
V
L
G
A
V
F
G
L
I
A
G
H
F
G
Y
A
G
A
V
K
---------
T
Y
I
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
L
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
----
L
A
T
S
A
M
A
V
F
F
G
L
I
V
G
R
L
F
N
V
G
A
N
V
N
L
G
S
G
T
G
K
A
I
E
A
Q
P
P
-------
S
L
V
Q
T
L
L
N
I
V
P
T
N
------------------------------
P
F
A
S
L
A
K
G
-
E
V
L
P
V
I
F
F
A
I
I
L
G
I
A
I
--------
T
Y
L
M
--------
N
--------
R
N
E
E
R
V
R
K
S
A
E
T
L
L
R
V
F
D
G
L
A
E
A
M
Y
L
I
V
G
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
R
V
V
G
P
L
A
K
V
V
G
A
------
V
Y
T
G
L
F
L
Q
I
V
I
T
Y
F
I
L
L
K
V
F
GI
D
P
I
K
F
I
R
K
A
K
D
A
M
I
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
E
E
E
M
G
V
D
K
G
I
F
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
T
V
L
F
V
A
N
A
I
G
H
P
L
T
L
G
Q
Q
L
V
V
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
Q
S
V
G
L
DLT
P
G
S
------
P
------
V
A
L
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
A
G
T
V
I
V
--------
A
K
T
E
K
E
L
D
E
S
K
W
I
S
H
-----------------------------------
40
PsiBlast_CBE
91.02
31%
-141
- C8 -
3V8G
1
?
B:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
-------
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
C
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
15
PsiBlast_PDB
91.01
31%
-138
- C8 -
4P1A
-
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
---------------------------------------------------
7
PsiBlast_PDB
90.96
31%
-135
- C8 -
4OYF
-
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
---------
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
2
PsiBlast_PDB
90.78
31%
-134
- C8 -
4OYG
1
?
A:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
22
PsiBlast_CBE
90.72
31%
-135
- C8 -
4OYG
1
?
D:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
20
PsiBlast_CBE
90.63
31%
-133
- C8 -
4OYG
1
?
F:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
3
PsiBlast_PDB
90.61
31%
-137
- C8 -
4OYE
-
?
A:
[12-405]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
-------
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
16
PsiBlast_PDB
90.59
31%
-138
- C8 -
4P3J
-
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
-----------------------------------------------------
24
PsiBlast_CBE
90.58
31%
-134
- C8 -
4OYG
1
?
B:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
21
PsiBlast_CBE
90.50
31%
-134
- C8 -
4OYG
1
?
E:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
11
PsiBlast_PDB
90.44
31%
-136
- C8 -
3KBC
1
?
A:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
43
PsiBlast_CBE
90.40
31%
-136
- C8 -
3KBC
1
?
C:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
14
PsiBlast_PDB
90.39
31%
-137
- C8 -
4P19
-
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
V
--------------------------------------------------
60
Fugue
90.31
33%
-134
* C8 *
4OYF
-
?
A:
[9-416]
------------------------------------
E
Y
P
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
-
I
L
G
H
----
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
------------------
I
H
L
A
V
G
G
Q
L
V
H
I
L
L
D
I
V
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
--------
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
--
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
--
L
K
I
Y
-
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
35
PsiBlast_CBE
90.24
31%
-143
- C8 -
3V8F
1
?
B:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
C
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
44
PsiBlast_CBE
90.14
31%
-136
- C8 -
3KBC
1
?
B:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
5
PsiBlast_PDB
90.03
31%
-132
- C8 -
2NWW
1
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
23
PsiBlast_CBE
90.01
31%
-135
- C8 -
4OYG
1
?
C:
[19-416]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
------
A
K
T
E
------------------------------------------------
8
PsiBlast_PDB
90.00
31%
-142
- C8 -
3V8F
1
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
C
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
31
PsiBlast_CBE
89.83
31%
-134
- C8 -
2NWX
2
?
B:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
---------
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
6
PsiBlast_PDB
89.81
31%
-133
- C8 -
2NWX
2
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
-----
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
1
PsiBlast_PDB
89.53
31%
-140
- C8 -
4X2S
1
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
34
PsiBlast_CBE
89.50
31%
-142
- C8 -
3V8F
1
?
C:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
C
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
49
HHSearch
89.03
32%
-135
- C8 -
2NWL
2
?
A:
[10-416]
-----------------------------------------
Y
P
V
L
I
K
I
L
I
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
--------
Q
-
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
-------------------------------
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
--------
T
Y
L
M
--------
N
SEN
E
K
V
R
K
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
-
V
-
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
--
L
K
-
I
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
D
P
N
V
A
A
A
------
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
32
PsiBlast_CBE
88.84
31%
-133
- C8 -
2NWW
1
?
C:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
30
PsiBlast_CBE
88.76
31%
-130
- C8 -
2NWX
2
?
C:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
----
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
18
PsiBlast_CBE
88.45
31%
-134
- C8 -
4X2S
1
?
C:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
V
--------------------------------------------------
33
PsiBlast_CBE
88.43
31%
-132
- C8 -
2NWW
1
?
B:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
12
PsiBlast_PDB
87.69
31%
-134
- C8 -
4IZM
1
?
A:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVA
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
19
PsiBlast_CBE
87.45
31%
-134
- C8 -
4X2S
1
?
B:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
48
PsiBlast_CBE
87.38
31%
-139
- C8 -
2NWL
2
?
B:
[41-412]
-------------------------------------------------------------------------
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
---------
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
45
PsiBlast_CBE
87.34
31%
-133
- C8 -
4IZM
1
?
C:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
46
PsiBlast_CBE
86.95
31%
-130
- C8 -
4IZM
1
?
B:
[19-412]
--------------------------------------------------
G
L
I
L
G
A
-
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
TYLMNSEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
13
PsiBlast_PDB
86.77
31%
-140
- C8 -
2NWL
2
?
A:
[41-412]
-------------------------------------------------------------------------
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
-----
P
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------
47
PsiBlast_CBE
86.66
31%
-137
- C8 -
2NWL
2
?
C:
[41-412]
-------------------------------------------------------------------------
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
-
L
A
V
G
G
Q
Q
F
Q
P
----
P
L
----
V
H
I
L
L
D
I
V
----
P
T
N
------------------------------
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
--------
K
--------
S
A
E
T
--------
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
--
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
--
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
------------------------------------------------------