@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SC5A1_HUMAN: (2015-12-11 )
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.-.......-100.-......110.......---120.-......130.......140.......150.......160.......170...-----.--.--..--180-........190.......200.......210.......220......-.230.......240.......250.......260.......270--.......-.280........290.......300.--------......310.......320.......330.......340.......350.......360.......370.......380.......390..-.....400.......410-.-......420.......430.......440.......450.......460.......470.......480--------.-------..----.....490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600...-....610.......620.......630.......640.......650.......660..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDSSTWSPKT
T
A
VTRP
V
E
T
H
E
L
I
R
NAAD
I
S
I
I
V
I
Y
F
V
V
V
M
A
V
G
L
W
A
M
FSTNRGT
V
G
G
F
F
LAG
R
S
M
V
W
W
PI
G
A
S
L
F
A
S
NIGS
G
H
F
V
G
L
AGTGA-AS
G
I
A
I
G-GFE
W
-
N
A
L
V
L
V
V
V
L
G
W
L
F
V
P
I
---
Y
I
KA-GV
V
T
M
P
E
Y
L
R
K
RFGG
Q
R
I
Q
V
Y
L
S
L
L
S
L
L
L
Y
I
F
T
K
I
S
A
D
IFS
G
A
I
F
I
N
L
A
L
G
L
-----
N
--
L
--
Y
L
--
A
I
--
F
L
L
L
A
I
T
A
L
Y
T
ITG
G
L
A
A
V
I
Y
T
D
T
L
Q
T
V
I
M
L
V
G
S
L
I
L
T
G
F
A
F
HEVG
G
-
Y
D
A
F
M
E
K
Y
M
K
AI
P
T
IVSDGNTT
F
Q
EKCYTPRAD
S
F
H
I
FRDPLT---GDLPW
P
G
-
F
I
F
-
G
M
S
I
L
T
L
W
Y
WC
T
D
Q
V
I
V
Q
R
C
L
S
--------AKN
M
S
H
VKG
G
C
I
L
C
G
Y
L
K
L
M
P
M
F
I
M
V
M
P
G
M
I
S
R
I
L
Y
T
E
K
I
A
C
VV
P
S
E
C
E
K
YCGTKVGCTNIA
Y
P
T
L
V
V
E
LMPN
G
L
R
G
L
M
L
S
V
M
L
A
S
L
M
S
S
L
-
T
S
I
F
NSAS
T
L
F
T
M
D
I
Y
A
K
-
V
-
R
K
RASEK
E
L
M
I
A
G
R
L
F
I
L
V
LIGI
S
I
A
W
V
P
IVQSAQS
G
Q
L
F
D
Y
I
Q
S
I
T
S
YLG
P
P
I
A
A
V
F
L
L
A
I
F
W
K
RVN---------E-------PG----
A
F
W
G
L
I
L
G
L
L
I
G
I
S
R
M
I
T
E
FAYGTGSCMEPSNC
P
T
I
I
C
G
V
H
Y
L
Y
F
A
I
I
L
F
A
I
S
F
I
T
I
V
V
I
S
L
L
TKPIP
D
V
H
L
Y
R
L
C
W
S
LRNSKEERIDLDA
E
E
E
N
I
Q
EGPK
E
T
I
E
I
E
TQV
P
E
K
K
K
G
I
F
R
R
A
-
Y
D
L
F
CGLEQHGAPKM
T
E
E
E
E
K
A
M
K
M
KMTDTSEK
P
L
W
R
T
V
LNVN
G
I
I
L
V
T
V
A
V
F
C
H
A
YFA
4
HHSearch
94.44
29%
-153
- C4 -
2XQ2
3
SGLT_VIBPH
A:
[9-514]
------------------------
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
-----------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
-
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
-
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
--
M
Y
--
S
I
--
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
-
T
D
G
W
F
A
G
V
S
K
M
V
D
A
----------------
A
P
G
H
F
E
M
I
L
D
Q
S
N
PQY
M
N
L
P
G
I
A
-
V
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
-----
N
L
P
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
M
L
G
--
G
I
G
Q
C
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
------------------
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
-
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
-
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
-------------------------------------------
1
PsiBlast_PDB
89.65
30%
-152
- C4 -
2XQ2
3
SGLT_VIBPH
A:
[12-461]
---------------------------
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
-----------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
-
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
-
N
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
--
M
Y
--
S
I
--
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
-
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
-------------
S
N
P
Q
Y
---
M
N
L
P
G
I
A
V
L
I
G
-
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
-----
N
L
P
S
A
A
N
A
D
K
A
Y
P
W
L
-
T
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
M
L
G
G
I
--
G
Q
C
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
---------------------------------------------------------------
14
Fugue
80.52
27%
-100
- C4 -
3DH4
1
?
A:
[52-518]
------------------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
-
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
--
M
Y
--
S
I
--
L
G
L
A
L
F
A
L
V
Y
S
------
I
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
-
T
D
G
W
F
A
G
V
S
K
M
V
D
A
-------------
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
---
M
N
L
P
G
I
A
-
V
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
D
I
A
A
T
N
L
P
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
-
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
--
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
------------------
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
-----------------------------------------------------------------------
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
2
PsiBlast_PDB
73.09
30%
-92
- C4 -
3DH4
1
?
A:
[52-432]
------------------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
-
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
-
N
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
--
M
Y
--
S
I
--
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
-
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
-------------
S
N
P
Q
Y
---
M
N
L
P
G
I
A
V
L
I
G
-
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
D
I
A
A
T
N
L
P
S
A
A
N
A
D
K
A
Y
P
W
L
-
T
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
--
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
-----------------------------------------------------------------------------------------
6
HHSearch
58.31
14%
-136
- C4 -
2JLN
-
?
A:
[22-454]
-----------------------------------------------------------
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
F
I
A
A
G
Q
--
M
-
T
S
S
F
Q
V
W
-
Q
V
I
V
-
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
-
G
-
I
N
F
T
V
A
A
R
M
P
F
G
I
R
-
G
S
L
I
P
I
T
L
K
A
L
L
S
-
L
F
W
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
TGFT
N
--
L
--
P
L
--
W
I
--
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
G
E
V
M
S
M
G
----
G
E
-----------------
N
--------------
P
G
M
P
F
S
--
T
A
I
-
M
I
F
V
G
G
W
I
A
V
V
V
S
I
H
D
I
V
K
E
C
K
VDPNAS
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
-
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
M
V
L
V
G
E
------------------
W
N
P
V
I
A
I
T
E
V
V
G
G
-
V
S
I
P
M
A
I
L
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
-
T
F
P
R
-
V
-
F
T
---------
F
K
T
G
-
V
I
V
S
A
V
V
G
L
L
M
M
P
W
----
Q
F
A
G
V
L
N
T
F
L
N
L
L
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
RIS
L
H
D
L
Y
R
T
KGIYTYW
R
G
VN
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
D
-----------------------
L
---
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
R
P
I
G
P
----------------------------------------------------------------------------------------------
21
Fugue
37.17
15%
354
* C4 *
2L5G
-
GPS2_HUMAN
A:
[53-90]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
E
M
E
E
R
M
S
L
E
E
T
K
E
Q
I
L
K
L
E
E
K
L
L
A
L
Q
E
E
K
H
Q
L
F
L
Q
L
----------------------------------------------------------------
17
Fugue
36.15
15%
234
- C4 -
3T97
-
NUP54_RAT
B:
[345-402]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
T
K
Q
H
Q
T
R
L
D
I
I
S
E
D
I
S
E
L
Q
K
N
Q
T
T
T
M
A
K
I
A
Q
Y
K
R
K
L
M
D
L
S
-
H
R
T
L
Q
V
L
I
K
Q
E
I
Q
R
K
S
-------------------------------------------
3
PsiBlast_PDB
36.13
34%
38
- C4 -
3MIX
-
FLHA_BACSU
A:
[500-548]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
P
V
L
V
E
E
V
T
P
N
P
L
S
V
G
D
I
Q
K
V
L
A
K
L
L
K
E
K
-
V
S
I
R
N
L
V
T
I
F
E
T
L
A
D
Y
G
K
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
35.99
9%
181
- C4 -
1X8Y
-
LMNA_HUMAN
A:
[313-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
K
E
A
K
L
R
D
L
E
D
S
L
A
R
E
R
D
T
S
R
R
L
L
A
E
K
E
R
E
M
A
E
M
R
A
R
M
-
Q
Q
Q
L
D
E
Y
Q
E
L
L
D
I
K
L
A
L
D
M
E
I
H
A
Y
R
K
L
L
E
G
E
E
E
R
-------------------------
23
Fugue
35.66
12%
182
- C4 -
3VP9
3
TUP1_YEAST
A:
[17-86]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
R
Q
E
F
L
Q
V
S
Q
E
A
N
T
Y
R
L
Q
N
Q
K
D
Y
D
F
K
M
N
Q
Q
L
A
E
M
Q
Q
I
R
N
T
-
V
Y
E
R
-
E
L
T
H
R
K
M
K
D
A
Y
E
E
E
I
K
H
L
K
L
G
L
E
Q
------------------------------
7
HHSearch
35.42
14%
-95
- C4 -
3L1L
2
ADIC_ECO57
A:
[8-169]
--------------------------------------------------------------
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
-
S
T
G
G
I
A
I
Y
G
W
L
V
-
T
I
I
G
-
A
L
G
L
S
M
V
Y
A
K
M
---
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
-
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
-----
L
KD
P
--
W
V
--
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
-
E
T
Y
M
A
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
---
G
G
V
L
I
A
A
-
V
C
Y
-
V
L
S
T
T
A
I
M
G
M
I
P
N
A
A
L
R
V
S
A
S
P
--------
F
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
-
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
-
A
-
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
---------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
35.24
11%
202
- C4 -
2W83
2
JIP4_HUMAN
C:
[1-67]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
P
E
F
M
G
R
E
V
E
N
L
I
L
E
N
T
Q
L
L
E
T
K
N
A
L
N
I
V
K
N
D
L
I
A
K
V
-
D
E
L
T
C
E
K
D
V
L
Q
G
E
L
E
A
V
K
Q
A
K
L
K
L
E
E
K
N
-------------------------------
8
HHSearch
35.13
14%
-94
- C4 -
3GIA
3
Y609_METJA
A:
[6-166]
--------------------------------------------------------------
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
-
F
G
V
G
A
K
I
A
G
R
N
-
L
-
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
---
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
-----
P
--
I
N
T
F
N
I
A
I
T
--
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
P
-
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
---
K
N
V
P
R
A
I
-
F
I
S
-
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
--------
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
-
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
-
L
-
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
---------
N
-------
N
M
----
Y
V
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
35.01
8%
124
- C4 -
4QKW
-
MURC_DANRE
A:
[3-103]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
S
A
L
S
I
L
S
L
L
E
R
V
S
T
I
I
D
G
V
Q
A
S
Q
Q
R
M
E
E
R
Q
Q
Q
L
E
G
S
V
S
A
V
Q
S
E
L
L
K
L
A
R
D
H
G
A
T
A
T
T
V
D
K
L
-
L
Q
K
A
R
R
V
S
T
H
V
K
E
V
R
S
R
V
E
K
Q
N
V
R
V
K
K
V
E
T
T
Q
D
E
L
L
T
R
---------------------
18
Fugue
34.33
10%
140
- C4 -
1X79
2
RABE1_HUMAN
B:
[3-92]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
R
D
Q
V
K
K
L
Q
L
M
L
R
Q
A
N
D
Q
L
E
K
T
M
K
D
K
Q
E
L
E
D
F
I
K
Q
S
S
E
D
S
S
H
Q
I
S
A
L
V
L
R
A
Q
A
S
-
E
I
L
L
E
E
L
Q
Q
G
L
S
Q
A
K
R
D
V
Q
E
Q
M
A
V
L
M
Q
S
R
E
Q
V
S
E
E
------------------------
19
Fugue
34.02
5%
27
- C2 -
2KUT
-
?
A:
[1-122]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
L
P
I
T
L
S
K
E
T
P
F
E
G
E
E
I
T
V
S
A
R
V
T
N
R
G
A
A
E
A
H
N
V
P
V
A
V
Y
L
G
N
P
A
Q
G
G
V
E
I
G
R
D
T
I
S
R
I
P
V
G
G
T
G
L
A
R
V
Q
W
K
A
T
R
K
L
A
G
R
A
A
N
P
G
V
P
V
Y
A
V
V
D
P
D
N
R
V
A
E
S
D
K
A
N
N
V
F
S
R
I
V
K
V
L
E
H
H
H
H
H
H
----------------------
9
HHSearch
27.43
24%
389
- C4 -
3WU2
-
PSBJ_THEVL
J:
[6-34]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
P
L
W
I
V
A
T
V
A
G
M
G
V
I
V
I
V
G
L
F
F
Y
G
A
Y
A
11
HHSearch
24.17
19%
1089
- C1 -
2CJR
-
NCAP_CVHSA
A:
[253-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
A
S
K
K
P
R
Q
K
R
T
A
T
K
Q
----------------
12
HHSearch
20.44
30%
393
- C4 -
2BEZ
1
?
C:
[45-71]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
T
L
V
K
Q
L
-
S
S
N
F
G
A
I
S
S
V
L
-
N
D
I
L
S
R
-
L
-
D
K
V
E
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
17.71
33%
1305
- C4 -
1WQC
-
KKX21_OPIMA
A:
[13-24]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
K
E
C
E
E
A
C
K
H
P
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------