@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SC5A3_HUMAN: (2015-12-11 )
MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVTIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGGFEEVKRRYMLASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFAYRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKNLVVKENCSPKEEPYQMQEKSILRCSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL
Atome Classification :
(20 SA)
.........10..------......20...----.....--30........40........50.........60........70........80........90........100-.........110.......120.......130.......140.......150....-----...160.......170.--......180.......190.......200..-.....----210.......220.......230.......240...-....250...---....260....-...-270.......280......--------.290.......300.......310.......320....--------...330.......340.......350.......360.......370.....-..-380.......390....-.-.-.400.......410.......420.......430.......440.......450.......460....---------.-------..----470.......480----........490...---....500.......510.......520.......530.......540.......550.........560.......570.......580.......590.......600.......610.......620........630.......640......-.650.......660--.......670.......680.......690.......700.......710......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRAVLD
T
A
D
I
A
I
V
------
A
L
Y
F
I
L
V
M
C
I
G
----
F
F
A
M
W
--KSNR
S
T
V
S
G
Y
F
LAGR
S
M
T
W
V
T
-I
G
A
S
L
F
V
S
NIGSE
H
F
I
G
LAGSGAASG
F
A
V
G
A
W
E
F
N
A
L
L
L
L
Q
L
L
G
W
V
F
I
P
I
---
Y
IRSGV
Y
T
M
P
E
Y
L
S
K
R
FGG
H
R
I
Q
V
Y
F
A
A
L
S
L
I
L
Y
I
F
T
K
L
S
V
D
LYS
G
A
L
F
I
QESLG
W
-----
N
L
Y
V
S
V
I
L
L
I
G
M
T
A
L
L
T
--VTG
G
L
V
A
V
I
Y
T
D
T
L
Q
A
L
L
M
I
I
G
A
L
T
L
M
I
I
S
I
-
M
EIG
G
----
F
E
E
V
K
R
R
YMLASPD
V
T
S
I
L
L
T
Y
NLSNTNSCNVS
P
K
K
-
E
A
L
K
M
LRNPT---DEDVPWP
G
F
I
L-GQT-P
A
S
V
W
Y
W
C
A
D
Q
V
I
V
Q
R
V
L
A
--------
A
KNIAHAKG
S
T
L
M
A
G
F
L
K
L
L
P
M
F
I
I
VV
P
G
M
I
S
R
I
L
FTD--------DIACINPE
H
C
M
L
V
CGSRAGCSNI
A
Y
P
R
L
V
M
K
L
V
P
V
G
L
R
G
L
M
M
A
V
M
I
A
A
L
M
S
-
D
L
-
D
S
I
F
NSAS
T
I
F
T
L
D
V
Y
K
-
L
-
I
-
R
KSASSR
E
L
M
I
V
G
R
I
F
V
A
F
M
V
V
I
S
I
A
W
V
P
I
I
V
E
MQG
G
Q
M
Y
L
Y
I
Q
E
V
A
D
YLT
P
P
V
A
A
L
F
L
L
A
I
F
W
K
R
CN---------E-------QG----AFYG
G
M
A
G
F
V
L
G
-----
A
V
R
L
I
L
A
F
A
YRAPE---CDQPDNRPG
F
I
K
D
I
H
Y
M
Y
V
A
T
G
L
F
W
V
T
G
L
I
T
V
I
V
S
LLTPPP
T
K
E
Q
I
R
T
T
T
F
WSKK--
N
L
V
V
KENCSPKEE
P
Y
Q
M
Q
E
K
S
I
LRCSENNE
T
I
N
H
IIPNGKSEDSIKGLQPED
V
N
L
L
V
T
CREEGNPVASLG-HSEAETPVDAYSNG
Q
A
ALMG
E
K
E
RKKET-DDGG
R
Y
W
K
F
I
D
W
F
C--GFKSKS
L
S
K
R
S
L
R
D
L
M
E
E
E
A
V
C
L
Q
M
L
E
ETR
Q
V
K
V
I
L
N
I
G
L
F
A
V
C
S
L
G
I
F
M
F
V
YFSL
20
HHSearch
99.02
30%
-136
* C3 *
2XQ2
3
SGLT_VIBPH
A:
[9-514]
-----
S
F
I
D
I
M
V
F
------
A
I
Y
V
A
I
I
I
G
V
G
----
L
W
V
S
-------------------
L
P
W
W
A
-
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
-
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
--
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
G
----
T
D
G
W
F
A
G
V
S
K
M
V
D
A
-
A
-----------------
P
---
G
H
F
E
M
I
L
D
Q
S
NPQ
Y
M
N
L
P
G
I
A
V
L
I
G
G
L
W
-
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
--------
P
Q
L
M
A
S
L
G
-----
N
L
P
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
-
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
-
E
Y
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
M
L
G
G
--
I
G
Q
C
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
-----
L
F
L
K
F
M
P
---------------------
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
-
P
K
G
I
S
V
T
S
S
M
--
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
--------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.31
31%
-148
- C3 -
2XQ2
3
SGLT_VIBPH
A:
[12-462]
--------
D
I
M
V
F
------
A
I
Y
V
A
I
I
I
G
V
G
-------
L
W
VS----------------
L
P
W
W
A
-
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
--
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
G
TDG
W
F
A
G
V
S
K
M
-
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
---------------------
N
P
Q
---
Y
M
N
L
P
G
I
A
V
L
I
-
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G-----
N
L
P
--------
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
-
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
M
L
G
G
I
--
G
Q
C
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
-----
L
F
L
K
F
M
P
L
S
M
P
F
M
D
---
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
--
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
---------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
84.31
23%
-96
- C1 -
4Z2T
1
?
A:
[11-591]
-----
A
E
T
D
V
L
I
V
G
AG
P
A
G
A
M
S
A
T
L
L
A
S
L
G
I
R
S
L
M
I
N
R
W
--
R
S
T
S
P
G
P
R
S
H
I
I
N
Q
R
T
M
E
I
L
R
D
I
G
L
--------
E
E
S
A
K
S
L
A
V
P
K
E
Y
M
G
E
H
V
Y
A
T
S
L
A
G
E
E
F
G
R
I
P
A
W
A
S
--------
H
P
Q
A
H
A
E
H
E
L
A
S
P
S
R
Y
C
D
L
P
Q
L
Y
F
E
P
M
V
V
S
E
A
A
L
R
G
A
D
V
R
------
F
L
T
E
Y
L
G
----------
H
V
E
D
Q
D
G
V
T
A
R
L
L
D
H
V
S
G
A
E
Y
E
V
R
A
K
Y
I
I
G
A
----
D
G
A
H
S
L
V
A
Q
N
A
G
L
P
F
E
G
-----
Q
M
G
G
S
I
N
I
E
F
S
A
D
L
S
S
L
C
-----
E
H
R
K
G
D
M
Y
Y
M
F
V
-
A
A
L
R
M
I
R
----------
P
W
N
K
W
I
C
-
V
W
G
-
E
------------
I
T
K
E
E
A
--------
K
K
I
I
H
E
I
I
G
T
D
-----------
E
I
P
V
E
V
G
P
I
S
T
W
T
I
N
Q
--------
Q
Y
A
V
R
N
T
S
G
R
V
F
C
M
G
-----------
D
A
V
H
R
H
T
P
M
G
G
L
G
L
N
T
S
V
Q
D
A
Y
N
L
A
W
K
L
-
A
L
V
L
K
G
T
A
A
P
T
L
L
D
S
Y
D
-
A
-
E
-
R
S
P
V
A
K
Q
---
I
V
E
R
A
F
K
S
L
S
T
------
F
P
P
V
F
E
A
L
S
L
P
P
A
P
T
E
S
E
M
A
E
A
L
V
R
L
K
D
A
S
------
E
E
G
A
K
---------
R
-------
R
A
----
A
L
R
K
A
M
D
A
T
I
I
G
LGGGH
G
V
E
L
N
Q
R
Y
V
S
R
A
V
F
---
P
D
G
T
P
D
-
P
G
F
V
R
D
Q
E
F
F
Y
Q
A
S
T
R
---
P
G
A
H
L
P
H
V
W
L
T
---
E
N
Q
R
R
I
S
T
L
D
L
C
G
K
G
R
F
T
L
L
T
G
L
S
G
A
A
W
K
H
E
A
E
Q
V
S
Q
S
L
-----------------------------
G
I
E
L
K
V
C
V
I
G
P
G
Q
E
------------
F
V
D
T
Y
--------
G
E
Y
A
K
I
S
E
I
-
G
E
S
G
A
L
L
V
R
P
D
M
F
I
--
A
F
R
A
K
D
A
S
R
E
G
L
E
Q
L
---
N
V
A
V
K
S
I
L
G
R
----------------------------
30
Fugue
79.29
28%
-81
- C3 -
3DH4
1
?
A:
[52-518]
-----------------------------------------------------
A
G
K
S
L
P
W
W
A
-
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
--------
I
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
G
----
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
-----------------
P
G
H
F
-
E
M
I
L
D
Q
S
N
P
Q
---
Y
M
N
L
P
G
I
A
V
L
I
G
G
L
W
-
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
--------
P
Q
L
M
A
S
L
G
D
I
A
A
T
N
L
P
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
-
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
-
E
-
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
--
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
-----
L
F
L
K
F
M
P
L
S
M
---------------------
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
--
V
-----------------------------------------------------------------------------------------------------------------------------
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
------------------
17
PsiBlast_CBE
70.77
32%
-75
- C3 -
3DH4
1
?
D:
[52-433]
-----------------------------------------------------
A
G
K
S
L
P
W
W
A
-
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
--
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
G
TDGW
F
A
G
V
S
K
M
----------------------
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
---
Y
M
N
L
P
G
I
A
V
L
I
-
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
PQLMASLG
D
I
A
A
T
N
L
P
--------
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
-
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
--
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
-----
L
F
L
K
F
M
P
L
S
M
P
F
M
D
---
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
--
V
L
Y
T
L
F
W
V
L
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
70.72
32%
-75
- C3 -
3DH4
1
?
A:
[52-433]
-----------------------------------------------------
A
G
K
S
L
P
W
W
A
-
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
--
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
G
TDG
W
F
A
G
V
S
K
M
----------------------
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
---
Y
M
N
L
P
G
I
A
V
L
I
-
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
D
I
A
A
T
N
L
P
--------
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
-
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
--
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
-----
L
F
L
K
F
M
P
L
S
M
P
F
M
D
---
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
--
V
L
Y
T
L
F
W
V
L
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_CBE
70.64
32%
-76
- C3 -
3DH4
1
?
C:
[52-433]
-----------------------------------------------------
A
G
K
S
L
P
W
W
A
-
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
--
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
G
TDGW
F
A
G
V
S
K
M
----------------------
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
---
Y
M
N
L
P
G
I
A
V
L
I
-
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
PQLMASLG
D
I
A
A
T
N
L
P
--------
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
-
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
--
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
-----
L
F
L
K
F
M
P
L
S
M
P
F
M
D
---
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
--
V
L
Y
T
L
F
W
V
L
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_CBE
70.62
32%
-75
- C3 -
3DH4
1
?
B:
[52-433]
-----------------------------------------------------
A
G
K
S
L
P
W
W
A
-
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
--
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
-
S
F
I
G
G
TDGW
F
A
G
V
S
K
M
----------------------
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
---
Y
M
N
L
P
G
I
A
V
L
I
-
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
PQLMASLG
D
I
A
A
T
N
L
P
--------
S
A
A
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
-
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
--
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
-----
L
F
L
K
F
M
P
L
S
M
P
F
M
D
---
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
--
V
L
Y
T
L
F
W
V
L
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
61.67
14%
-115
- C3 -
2JLN
-
?
A:
[22-455]
----------------------------------------------------
Y
A
E
R
S
V
G
P
F
S
-
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
F
I
A
A
G
Q
--
M
T
S
S
F
Q
V
W
Q
V
I
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
G
-
I
N
F
T
V
A
A
R
M
P
F
G
I
R
-
G
S
L
I
P
I
T
L
K
A
L
L
S
-
L
F
W
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
TGFT
N
L
P
L
W
I
V
I
F
G
A
I
Q
V
V
T
T
---
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
-
D
G
A
D
V
S---
L
G
E
V
M
S
M
G
----
G
E
N
------------------------------------
P
G
M
P
F
S
T
-
A
I
-
M
I
F
-
V
G
G
W
I
A
V
V
V
S
I
H
D
I
V
K
E
C
K
VDPNAS
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
-
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
M
V
L
V
G
E
--------------------------
W
N
P
V
I
A
I
T
E
V
V
G
G
-
V
S
I
P
M
A
I
L
F
Q
V
F
V
L
L
A
T
W
S
-
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
-
T
F
P
-
R
-
V
-
F
T
---------
F
K
T
G
-
V
I
V
S
A
V
V
G
L
L
M
M
P
W
-
Q
-
F
--
A
G
V
L
N
T
F
L
N
L
L
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
RIS
L
H
D
L
Y
R
T
KGIYTYW
R
G
VN
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
-----
F
L
T
P
D
--------------------------
L
---
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
--
L
R
P
I
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
40.24
27%
86
- C3 -
1QL6
-
PHKG1_RABIT
A:
[188-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
--------
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
----------
F
W
H
R
K
--
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
V
------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
39.90
27%
72
- C3 -
2PHK
1
PHKG1_RABIT
A:
[175-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
--------
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
----------
F
W
H
R
K
--
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
-------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
38.74
27%
87
- C3 -
1PHK
-
PHKG1_RABIT
A:
[188-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
--------
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
----------
F
W
H
R
K
--
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
V
------------------------------------------------------------------------------------------------------------------
38
Fugue
37.49
18%
235
- C3 -
2Q2F
1
SELS_HUMAN
A:
[18-88]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
A
R
L
R
A
L
R
Q
R
Q
L
D
R
A
A
A
A
V
E
P
D
V
V
V
K
R
Q
E
A
L
A
A
A
R
L
K
M
Q
E
E
L
N
A
Q
V
E
K
H
K
E
K
L
K
Q
L
E
E
E
K
R
R
Q
K
I
E
M
W
D
S
M
--------------------------------------------------------------------
31
Fugue
36.59
15%
150
- C3 -
2Q97
1
?
T:
[1-109]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
Q
E
L
G
L
L
R
P
E
E
R
L
I
A
G
Q
A
K
A
A
A
L
Q
T
V
H
Q
L
G
A
V
A
L
T
P
E
Q
A
K
A
A
L
L
D
E
I
L
R
A
T
Q
N
L
D
L
R
K
Y
E
N
L
N
T
E
Q
Q
K
A
-
Y
E
Q
V
Q
R
D
L
S
Q
L
S
P
E
T
K
A
L
L
I
E
N
Q
R
K
E
K
T
-
L
L
E
K
A
R
K
L
F
Q
R
-------------------------------------------------------------
11
PsiBlast_PDB
35.82
38%
247
- C3 -
1R9O
1
CP2C9_HUMAN
A:
[99-143]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
K
K
W
K
E
I
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
R
C
L
--
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
I
I
F
4
PsiBlast_PDB
34.70
38%
241
- C3 -
2NNH
1
CP2C8_HUMAN
A:
[98-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
--
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
5
PsiBlast_PDB
33.33
38%
256
- C3 -
2NNI
1
CP2C8_HUMAN
A:
[98-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
--
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
16
PsiBlast_PDB
32.81
23%
5
* C4 *
1H6F
2
TBX3_HUMAN
A:
[73-157]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
A
G
K
A
---
D
P
E
M
P
K
R
M
Y
I
H
-
P
D
S
-
P
A
T
G
E
Q
W
M
S
K
V
V
T
F
H
K
L
K
L
--------
T
N
N
I
S
D
K
H
G
F
T
I
L
N
S
M
H
K
Y
Q
P
R
F
H
I
V
R
A
N
D
I
L
K
L
P
Y
S
T
--------
F
R
T
Y
L
F
P
E
T
E
F
I
A
V
T
A
Y
Q
N
D
K
I
T
Q
L
K
I
D
N
N
P
F
A
K
G
F
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
32.51
36%
610
- C3 -
1LBJ
-
A:
[1-22]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
P
I
F
T
Y
G
E
L
Q
R
M
Q
E
K
E
R
N
K
G
Q
-------------------------------------------------------------------------
35
Fugue
32.37
9%
170
- C3 -
2L9Q
-
HSP12_YEAST
A:
[1-109]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
S
D
A
G
R
K
G
F
G
E
K
A
S
E
A
L
K
P
D
S
Q
K
S
Y
A
E
Q
G
K
E
Y
I
T
D
K
A
D
K
V
A
G
K
V
Q
P
E
D
N
K
G
V
F
Q
G
V
H
D
S
A
E
K
G
K
D
N
A
E
G
Q
G
-
E
S
L
A
D
Q
A
R
D
Y
M
G
A
A
K
S
K
L
N
D
A
V
E
Y
V
S
G
R
-
V
H
G
E
E
D
P
T
K
K
--------------------------------------------------------------