@TOME V2.2
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SC5A4_HUMAN: (2015-12-11 )
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLKKAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.-.......-100..-.....110.......---120.-......130.......140.......150.......160.......170...-----.--...--180.......190.......200.......210.......220......-.230---.......240.......250.......260.......270--........---280........290.......300.--------......310.......320.......330.......340.......350.......360..--------.....370.......380.......390..-.....400.......410-.-......420.......430..-----.....440.......450-.......460.......470...----....480--------.-------..----.....490.......500.......510.......520.......530......---.540.......550.......560.......570.......580.......-590.......600.......610.......620.......630.......640.......650.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASTVSPSTIAETPEPP
P
L
S
D
H
I
RNAA
D
I
S
V
I
V
I
Y
F
L
V
V
M
A
V
G
L
W
A
M
L
KTNRGT
I
G
G
F
F
LAGRDMAWWPM
G
A
S
L
F
A
S
NIGSN
H
Y
V
G
L
AGTGA-AS
G
V
A
T
V
-
T
F
EW
T
-
S
S
V
M
L
L
I
L
G
W
I
F
V
P
I
---YIKS-G
V
M
T
M
P
E
Y
L
K
K
RFG
G
E
R
L
Q
V
Y
L
S
I
L
S
L
F
I
C
V
V
L
L
I
S
A
D
I
F
A
G
A
I
F
I
K
L
A
L
G
L
-----
D
--
L
Y
L
--
A
I
F
I
L
L
A
M
T
A
V
Y
TTTGG
L
A
S
V
I
Y
T
D
T
L
Q
T
I
I
M
L
I
G
S
F
I
L
M
G
F
A
FNEVGG-
Y
E
S
F
---
T
E
K
Y
VNATPSVVEGD
N
L
T
I
S
A
S
CYTPRAD
S
F
H
I
F
R
D
AVT---GDIPWP
G
I
---
I
F-G
M
P
I
T
A
L
W
Y
W
C
T
N
Q
V
I
V
Q
R
CLC--------GK
D
M
S
H
V
K
A
A
C
I
M
C
A
Y
L
K
L
L
P
M
F
L
M
V
M
P
G
M
I
S
R
I
L
Y
T
D
M
V
A
CV
V
P
S
E
C
V
K
HCGVDVGCTNY--------
A
Y
P
T
M
V
L
E
L
M
P
Q
G
L
R
G
L
M
L
S
V
M
L
A
S
L
M
S
S
L
-
T
S
I
FNSAS
T
L
F
T
I
D
L
Y
T
K
-
M
-
R
K
QASEK
E
L
L
I
A
G
R
I
F
V
L
L
L
T
-----
V
V
S
I
V
W
V
P
L
V
Q
VSQNG
Q
L
-
I
H
Y
T
E
S
I
S
S
YLG
P
P
I
A
A
V
F
V
L
A
I
----
F
C
K
R
VN---------E-------QG----
A
F
W
G
L
M
V
G
L
A
M
G
L
I
R
M
I
T
E
FAYGTGSCLAPSNC
P
K
I
I
C
G
V
H
Y
L
Y
F
S
I
V
L
F
F
G
S
M
---
L
V
T
L
G
I
S
L
LTKPIP
D
V
H
L
Y
R
L
C
W
V
L
RNSTEERIDIDAEEKSQEETDDGVEE-DYP
E
K
S
R
G
C
L
K
K
A
Y
D
L
F
CGLQKGPKL
T
K
E
E
E
E
A
L
S
K
KLTDTSERPS
W
R
T
I
V
N
I
N
A
I
L
L
L
A
V
V
V
F
I
HGYYA
3
HHSearch
96.22
27%
-153
- C3 -
2XQ2
3
SGLT_VIBPH
A:
[9-514]
------------------------
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
-----------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
M
-
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
-
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
Y
--
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
-
T
D
G
W
---
F
A
G
V
S
K
M
V
D
A
----------------
A
P
G
H
F
E
M
I
L
D
Q
S
N
PQY
M
N
L
P
G
I
A
V
---
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
-----
N
L
P
S
A
A
N
A
D
K
--------
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
-----
I
I
A
A
L
I
A
P
M
L
G
G
--
I
G
Q
C
-
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
----
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
------------------
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
---
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
-
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
-
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
--------------------------------------
1
PsiBlast_PDB
93.51
28%
-166
- C3 -
2XQ2
3
SGLT_VIBPH
A:
[9-468]
------------------------
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
-----------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
M
-
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
Y
--
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
-
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
------------------
M
I
L
D
Q
S
N
P
---
Q
Y
M
N
L
P
G
I
AVL
I
G
-
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
-------
P
Q
L
M
A
S
L
G
------
N
L
PSAANADK
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
-----
I
I
A
A
L
I
A
P
M
--
L
G
G
I
G
Q
C
-
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
----
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
---
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
-
V
I
G
T
I
L
L
I
S
Y
G
I
K
---------------------------------------------------------
13
Fugue
80.92
24%
-90
- C3 -
3DH4
1
?
A:
[52-518]
------------------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
M
-
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
Y
--
S
I
L
G
L
A
L
F
A
L
V
Y
S
------
I
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
-
T
D
G
W
---
F
A
G
V
S
K
M
V
D
A
A
-------------
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
---
M
N
L
P
G
I
A
V
---
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G
D
I
A
A
T
N
L
P
S
A
A
N
A
D
K
--------
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
-
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
-----
I
I
A
C
L
I
A
P
M
L
G
G
--
I
G
Q
A
-
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
----
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
------------------
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
---
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
------------------------------------------------------------------
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
2
PsiBlast_PDB
75.43
28%
-90
- C3 -
3DH4
1
?
A:
[52-439]
------------------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
M
-
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
Y
--
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
-
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
------------------
M
I
L
D
Q
S
N
P
---
Q
Y
M
N
L
P
G
I
AVL
I
G
-
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
-------
P
Q
L
M
A
S
L
G
-
D
I
A
A
T
N
L
PSAANADK
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
-
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
-----
I
I
A
C
L
I
A
P
M
--
L
G
G
I
G
Q
A
-
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
----
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
---
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
------------------------------------------------------------------------------------
5
HHSearch
61.84
13%
-136
- C3 -
2JLN
-
?
A:
[22-454]
-----------------------------------------------------------
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
F
I
A
A
G
Q
--
M
-
T
S
S
F
Q
V
W
-
Q
V
I
V
A
-
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
-
G
-
I
N
F
T
V
A
A
R
M
P
F
G
I
R
-
G
S
L
I
P
I
T
L
K
A
L
L
S
L
-
F
W
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
TGFT
N
--
L
P
L
--
W
I
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
G
E
V
---
M
S
M
G
----
G
E
----------------------------
N
---
P
G
M
P
F
S
T
----
A
I
-
M
I
F
V
G
G
W
I
A
V
V
V
S
I
H
D
I
V
K
E
C
K
VDPNAS
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
-
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
M
V
L
V
G
E
------------------
W
N
P
V
I
--------
A
I
T
E
V
V
G
G
-
V
S
I
P
M
A
I
L
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
-
T
F
P
R
-
V
-
F
T
---------
F
K
T
G
-
V
I
V
S
A
-----
V
V
G
L
L
M
M
P
W
--
Q
F
--
A
G
V
-
L
N
T
F
L
N
L
L
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
----
F
L
V
R
R
R
RIS
L
H
D
L
Y
R
T
KGIYTYW
R
G
VN
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
D
--------------------------
L
M
F
V
T
G
L
I
A
A
L
---
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
R
P
I
G
P
-----------------------------------------------------------------------------------------
14
Fugue
45.26
13%
-108
- C3 -
5AL7
-
SAS6_DROME
A:
[12-219]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
S
A
K
-
M
-
D
Y
G
K
S
V
V
N
I
L
P
S
V
E
M
L
V
N
F
N
G
DMTR
S
S
K
R
S
C
L
L
Y
A
E
R
V
D
F
K
E
L
L
Q
L
R
L
T
E
K
------
S
D
Q
R
R
M
Y
I
T
T
V
D
S
A
S
F
Q
D
L
K
Q
---------
D
-------
Q
S
----
L
N
V
S
-
F
S
G
F
I
D
N
V
V
R
M
L
K
D
C
Q
S
G
K
L
E
L
H
L
T
T
R
D
Q
N
L
S
S
G
R
E
V
H
D
Y
Y
L
Q
F
V
E
I
R
S
D
K
N
L
V
H
L
S
L
P
C
R
S
A
P
L
N
T
V
L
F
Y
I
N
S
M
L
E
A
S
H
K
K
Q
Y
I
L
E
Q
S
M
Q
Q
M
Q
A
E
I
N
A
Q
R
A
H
A
E
R
L
T
T
E
N
T
N
L
R
E
A
L
A
E
N
T
R
---------------------------------------------------
17
Fugue
40.77
22%
214
- C3 -
2Q6Q
-
SPC42_YEAST
A:
[3-64]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
N
K
E
L
N
F
K
L
R
E
K
Q
N
E
I
F
E
---
L
K
-
K
I
A
E
T
L
R
S
K
L
E
K
Y
V
D
I
T
K
K
L
E
D
Q
N
L
N
L
Q
I
K
I
S
D
L
E
K
K
L
S
D
A
-----------------------------
19
Fugue
40.58
16%
197
- C3 -
1X8Y
-
LMNA_HUMAN
A:
[313-386]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
K
E
A
K
L
R
D
L
E
D
S
L
A
R
-
E
R
D
T
S
R
R
L
L
A
E
K
E
R
E
M
A
E
M
R
A
R
M
Q
Q
Q
L
D
E
Y
Q
E
L
L
D
I
K
L
A
L
D
M
E
I
H
A
Y
R
K
L
L
E
G
E
E
E
R
-------------
15
Fugue
39.81
8%
213
- C3 -
2KZ9
-
VATE_YEAST
A:
[1-69]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
S
A
I
T
A
L
T
P
N
Q
V
N
D
E
L
N
K
M
Q
A
F
I
R
K
-
E
A
E
E
K
A
K
E
I
Q
L
K
A
D
Q
E
Y
--
E
I
E
K
T
N
I
V
R
N
E
T
N
N
I
D
G
N
F
K
S
K
L
K
K
A
-------------------------
16
Fugue
37.42
6%
193
- C3 -
1IC2
-
TPM1_CHICK
A:
[1-79]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
A
I
K
K
K
M
Q
M
L
K
L
D
K
E
N
A
L
D
R
A
E
Q
A
E
A
-
D
K
K
A
A
E
E
R
S
K
Q
L
E
D
E
L
V
A
L
Q
K
K
L
K
G
T
E
D
E
L
D
K
Y
S
E
S
L
K
D
A
Q
E
K
L
E
L
A
D
K
K
A
T
------------------
20
Fugue
37.14
15%
167
- C3 -
4DHX
-
GANP_HUMAN
A:
[1162-1233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
L
S
E
L
S
Q
G
L
A
V
E
L
M
E
R
V
M
M
E
F
V
R
E
T
C
S
Q
E
L
K
N
A
V
E
T
-
D
Q
R
V
R
V
A
R
C
C
E
D
V
C
A
H
L
V
D
L
F
L
V
E
E
I
F
Q
T
A
K
E
T
L
Q
-----------------------------------
7
HHSearch
36.21
15%
-94
- C3 -
3GIA
3
Y609_METJA
A:
[6-166]
--------------------------------------------------------------
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
-
F
G
V
G
A
K
I
A
G
R
N
-
L
-
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
---
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
-----
P
IN
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
P
-
S
Y
V
I
---
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
---
K
N
V
P
R
A
I
F
---
I
S
-
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
--------
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
--------
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
-
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
-
L
-
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
-----
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
-
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
----
T
K
R
T
F
S
---------
N
-------
N
M
----
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
35.20
8%
210
- C3 -
4CVO
-
A:
[9-77]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
Q
G
L
G
V
D
V
Y
D
Q
D
V
L
E
Q
G
V
L
Q
Q
V
D
N
A
-
I
H
E
A
S
R
A
S
Q
L
V
D
V
E
K
E
Y
R
S
V
L
D
D
L
T
S
C
T
T
S
L
R
Q
I
N
K
I
I
E
Q
L
S
----------------------------
22
Fugue
34.65
9%
350
* C3 *
2KWY
-
A:
[1-43]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
N
A
G
G
V
G
E
L
E
K
K
A
E
A
G
V
Q
G
E
L
A
E
I
K
K
-
I
A
E
K
K
K
D
D
V
V
K
I
L
I
E
T
------------------------------------------------------
6
HHSearch
32.93
14%
-94
- C3 -
3L1L
2
ADIC_ECO57
A:
[8-169]
--------------------------------------------------------------
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
-
S
T
G
G
I
A
I
Y
G
W
L
V
T
-
I
I
G
A
-
L
G
L
S
M
V
Y
A
K
M
---
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
-
L
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
-
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
-----
L
KD
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
-
E
T
Y
M
---
A
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
---
G
G
V
L
I
A
A
V
---
C
Y
-
V
L
S
T
T
A
I
M
G
M
I
P
N
A
A
L
R
V
S
A
S
P
--------
F
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
--------
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
-
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
-
A
-
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
-----
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
-
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
----
N
P
Y
P
L
D
---------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
31.61
25%
376
- C3 -
3WU2
-
PSBJ_THEVL
J:
[7-34]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
P
L
W
I
V
A
T
V
A
G
M
G
V
I
V
I
V
G
L
F
F
Y
G
A
Y
A
8
HHSearch
21.97
18%
858
- C2 -
2KNC
-
ITA2B_HUMAN
A:
[987-1003]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
W
K
V
G
F
F
K
R
N
R
P
P
L
E
E
D
----------------------------------------------------------------------------------------
9
HHSearch
15.99
31%
1116
* C2 *
1WQC
-
KKX21_OPIMA
A:
[13-25]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
K
E
C
E
E
A
C
K
H
P
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
4.33
14%
1204
- C2 -
2ZVV
1
Y:
[5-18]
--------------------------------------------------
R
Q
T
S
M
T
D
F
Y
H
S
K
R
R
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
2.58
20%
1460
- C1 -
2L9U
-
ERBB3_HUMAN
A:
[652-661]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
I
F
M
M
L
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------