@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SC5AC_HUMAN: (2015-12-11 )
MEVKNFAVWDYVVFAALFFISSGIGVFFAIKERKKATSREFLVGGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPHLSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSFWVAIGAFIYPAPASKTWPLPLSTDQCIKSNVTATGPPVLSSRPGIADTWYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLFCFWSKKYKTLCWCGVQHDSGTEQENLENGSARKQGAESVLQNGLRRESLVHVPGYDPKDKSYNNMAFETTHF
Atome Classification :
(20 SA)
-------.........10........20........30........40........50........60........70.....-.---.---------.80....-....90........100---....-...110.......120-----.-......130-.....-..-140.......150....-----.--..160..--.......170.......180.--......190..-.....200......--.210----........---.--220.......230..-....----.240.-......-250.-......260...--------....270.......280.......290.......300...------....---------310..--------.....320.......330.-.......340......--..-350.--.......360......-.-370..-.....380.......390.......400..-.....410.---......420.......430..---------.-------..----..440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600---.........610......--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MEV
K
N
F
A
V
W
D
Y
V
V
F
A
A
L
F
F
I
SSG
I
G
V
F
F
A
I
K
E
R
KKATSRE
F
L
VGGRQMSFGPV
G
L
S
L
T
A
S
F
M
S
A
V
TVLG
T
P
S
E
V
Y
R
-
F
---
G
---------
A
S
F
L
V
F
F
-
I
A
Y
L
F
V
I
L
L
T
S
E
L
F
L
P
V
---
F
Y
RS-G
I
T
S
T
Y
E
Y
L
Q
L
RFNKP-----
V
-
R
Y
A
A
T
V
I
Y
I
-
V
Q
T
I
L
-YT-
G
V
V
V
YAP
A
L
A
L
NQVT
G
F
-----
D
--
L
W
G
--
S
V
--
F
A
T
G
I
V
C
T
F
Y
C
T
LGGL
K
A
V
V
W
--
T
D
A
F
Q
M
V
V
M
I
V
-
G
F
L
T
V
L
IQGSTHA
G
--
G
F
------
H
N
V
L
E
QST---N--G
S
R
L
H
I
F
DFDVDPLR-R
H
T
F
----
W
T
I
T
V-G
G
T
F
T
W
-
L
G
I
Y-GV
N
Q
S
T
I
Q
R
C
I
S--------CKTEK
H
A
K
L
A
L
Y
F
N
L
L
G
L
W
I
I
L
V
C
A
V
F
S
G
L
I
M
Y
S
HFKDCD------PWTS---------GIISA--------
P
D
Q
L
M
P
Y
F
V
M
E
I
F
A
TMP-G-L
P
G
L
F
V
A
C
A-FS
G
T
L
S
--
T
V
-
A
S
-
S
--
I
N
A
L
A
T
V
T
F
E
D
F
V
K
S
C
-
F
-
P
H
L
S
D
-
K
L
S
T
W
I
SK
G
L
C
L
L
F
G
V
M
C
T
S
M
A
V
A
A
S
V
M
G
G
-
V
V
Q
A
S
L
S
I
H---GMCGG
P
M
L
G
L
F
S
L
G
I
V
FPFVN---------W-------K
G
----
A
L
G
G
L
L
T
G
I
T
L
S
F
W
V
A
I
G
A
FIYPAPASKTWPLPL
S
T
D
Q
C
I
KSNVTATGPPVLSSRPGIA
D
T
W
Y
S
I
S
Y
L
Y
Y
S
A
V
G
C
L
G
C
I
V
A
G
V
I
I
S
L
I
TGRQRGEDIQ
P
L
L
I
R
P
V
C
N
L
F
C
F
W
SKK
Y
K
T
L
C
W
C
GVQHDSGT
E
Q
ENLENG
S
A
R
K
Q
G
A
E
S
V
L
Q
NGLRRE
S
L
VHVPG-----YDPKDKSYNNM
A
F
ETTHF--
9
HHSearch
92.85
21%
-139
- C6 -
2XQ2
3
SGLT_VIBPH
A:
[9-506]
-------------
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
------------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
---
G
---------
L
A
I
A
S
Y
E
-
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
-----
L
-
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
-
N
L
-
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
Y
--
S
I
--
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
--
T
D
V
I
Q
V
F
F
L
V
L
-
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
--
G
T
------
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
M
N
L
P
G
----
I
A
V
L
I
G
G
L
W
V
A
N
-
L
Y
Y
W
-
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G--
N
L
---------
P
S
A
A
N
--------
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
--
V
-
G
-
V
K
G
V
V
F
A
A
L
-
A
A
A
I
V
S
--
S
L
-
A
S
-
M
--
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
-
P
D
S
G
D
-
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
M
L
G
G
I
G
Q
-
C
F
Q
Y
I
Q
E
Y
T
---
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
-------------------------------------------
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
---------------------------
1
PsiBlast_PDB
90.71
24%
-145
- C6 -
2XQ2
3
SGLT_VIBPH
A:
[12-470]
----------------
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
--
V
S
----------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
---
G
---------
L
A
I
A
S
Y
E
-
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
-----
L
-
K
T
I
L
A
V
F
W
I
-
S
L
Y
I
F
-
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
Y
--
S
I
--
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
--
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
TD
G
W
------
F
A
G
V
S
K
M
V
---
D
--
A
A
P
G
H
-
F
E
M
I
L
D
Q
S
N
-
P
Q
Y
M
NLPG
I
A
V
L
I
-
G
G
L
W
V
A
N
L
Y
Y
W
-
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
------
L
M
A
S
L
--------
G
----NLPSAAN-
A
D
K
A
Y
P
W
L
T
Q
----
F
L
P
V
G
-
V
K
G
V
V
F
A
A
L
-
A
A
A
I
V
S
--
S
L
-
A
S
-
M
--
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
P
D
S
G
D
-
H
K
L
V
N
V
G
R
T
A
A
V
---
V
A
L
I
I
A
A
L
I
A
P
M
L
G
G
-
I
G
Q
C
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
----------------------------------------------------------------------
19
Fugue
83.44
21%
-87
- C6 -
3DH4
1
?
A:
[52-518]
--------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
---
G
---------
L
A
I
A
S
Y
E
-
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
-----
L
-
K
T
I
L
A
V
F
W
I
-
S
L
Y
I
F
V
N
L
-
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
Y
--
S
I
--
L
G
L
A
L
F
A
L
V
Y
------
S
I
V
V
W
--
T
D
V
I
Q
V
F
F
L
V
L
-
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
--
G
T
DG
W
F
A
G
V
S
K
M
V
D
A
A
---
P
--
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
M
-
N
L
P
G
----
I
A
V
L
I
-
G
G
L
W
V
A
-
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
------
L
M
A
S
L
GDIAATNL
P
S
A
A
N
--------
A
D
K
A
Y
P
W
L
T
Q
F
L
---
P
V
-
G
-
V
K
G
V
V
F
A
A
L
-
A
A
A
I
V
S
--
S
L
-
A
S
-
M
--
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
P
D
S
G
D
-
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
G
Q
-
A
F
Q
Y
I
Q
E
Y
T
---
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
-------------------------------------------
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
------------------------------
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
-----
Y
K
------------------
24
Fugue
77.20
20%
-66
- C4 -
4ZH0
-
?
A:
[18-518]
-Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
L
I
G
D
K
A
N
---
S
P
A
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
Y
V
T
Q
-
C
---
G
G
N
A
NGQKSI
S
S
K
T
I
F
N
-
N
-------------
E
P
G
---
Y
R
S
T
-
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
G
P
MS
I
E
N
F
-
K
K
L
N
E
A
Y
Q
I
-
L
Q
T
A
L
-
K
R
-
G
L
----
P
A
L
K
E
N
N
G
---------------------
K
V
N
V
T
Y
T
Y
T
C
S
-----------------------------------
G
D
--
G
N
------
N
N
C
S
S
Q
V
T
---
G
----------------------------
V
N
N
-
Q
K
D
G
T
K
-
T
K
I
Q
-
T
I
D
G
K
S
V
T
T
T
I
S
--------
S
K
V
V
D
S
R
A
D
G
---
N
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
G
V
P
--
D
S
A
Q
A
L
L
------
A
Q
A
S
---------
T
L
I
N
T
--------
I
N
N
A
C
P
Y
F
H
A
P
K
F
S
T
T
T
-
G
------
K
I
C
G
A
F
S
E
E
I
S
--
A
I
-
Q
K
M
I
--
T
D
A
Q
E
L
V
N
Q
T
S
V
I
N
E
--------
H
-
E
Q
T
T
P
V
G
N
N
N
G
K
P
F
-----
N
P
F
T
D
A
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
---
M
-----------------------------------------------------
L
N
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
------
T
F
Q
N
F
V
K
G
F
L
A
T
C
N
N
P
S
Q
G
S
A
P
G
T
V
T
T
Q
T
F
A
S
----------
G
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
E
Q
Q
I
Q
Q
A
E
N
I
A
D
T
L
V
N
------
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
-
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
GID
T
N
Y
Y
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
--
2
PsiBlast_PDB
72.88
25%
-86
- C6 -
3DH4
1
?
A:
[52-441]
--------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
---
G
---------
L
A
I
A
S
Y
E
-
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
-----
L
-
K
T
I
L
A
V
F
W
I
-
S
L
Y
I
F
-
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
Y
--
S
I
--
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
W
--
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
TD
G
W
------
F
A
G
V
S
K
M
V
---
D
--
A
A
P
G
H
-
F
E
M
I
L
D
Q
S
N
-
P
Q
Y
M
NLPG
I
A
V
L
I
-
G
G
L
W
V
A
N
L
Y
Y
W
-
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
------
L
M
A
S
L
--------
G
D
I
A
A
TNLPSAAN
A
D
K
A
Y
P
W
L
T
Q
----
F
L
P
V
G
-
V
K
G
V
V
F
A
A
L
-
A
A
A
I
V
S
--
S
L
-
A
S
-
M
--
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
----
L
I
A
P
M
L
G
G
-
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
------------------------------------------------------------------------------------------------
11
HHSearch
65.58
14%
-130
- C6 -
2JLN
-
?
A:
[22-454]
-------------------------------------------------
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
F
I
A
A
G
Q
--
M
T
-
S
---
S
---------
F
Q
V
W
Q
V
I
-
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
-
G
-
I
N
F
T
V
A
A
R
M
P
F
G
I
R
-----
G
-
S
L
I
P
I
T
L
K
A
-
L
L
S
L
F
-
W
F
-
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
TGFT
N
--
L
P
L
--
W
I
--
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
W
--
M
N
V
F
A
S
P
V
L
L
A
-
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V-
S
L
------
G
E
V
M
S
M
G
G
---
E
---------------
N
P
-
G
M
P
F
----
S
-
T
A
I
-
M
I
F
V
G
G
-
W
I
A
V
-
V
V
S
I
H
D
I
V
K
E
C
K
VDPNAS
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
-
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
M
V
L
V
G
E
------------------------
W
N
--------
P
V
I
A
I
T
E
V
V
G
G
-
V
S
--
I
-
P
-
M
A
I
L
F
Q
V
F
V
-
L
L
A
T
W
S
--
T
N
P
A
A
-
N
--
L
L
S
P
A
Y
T
L
C
S
-
T
F
P
R
V
-
F
-
T
----------
F
K
T
G
-
V
I
V
S
A
V
V
G
L
L
M
M
P
W
Q
--
F
A
G
-
V
L
N
T
F
L
N
L
L
---
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
RIS
L
H
D
L
Y
R
T
KGIYTYW
R
G
VN
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
---
D
------------------------------------------------
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
R
P
I
G
P
----------------------------------------------------------------------------
28
Fugue
58.91
13%
-117
- C3 -
3C2W
1
BPHY_PSEAE
A:
[5-494]
TPVTLAN
C
E
D
E
P
I
H
V
P
G
A
I
Q
P
H
G
A
L
V
T
L
R
A
D
G
M
V
L
A
A
S
E
N
I
Q
A
L
L
G
F
V
A
S
P
G
S
Y
L
T
Q
E
Q
V
G
P
E
V
L
R
M
L
E
E
G
L
T
G
N
G
P
W
S
N
S
V
E
-
T
R
IG
E
---------
H
L
F
D
V
I
G
-
H
S
Y
K
E
V
F
Y
L
E
F
E
I
R
T
A
------
D
T
-
L
S
I
T
S
F
T
L
N
A
Q
R
I
I
A
Q
-----
V
-
Q
L
H
N
D
T
A
S
L
-
L
S
N
V
T
-
D
E
-
L
R
R
M
T
G
Y
----
D
R
V
M
A
Y
-----
R
--
F
R
H
--
D
D
--
S
G
E
V
V
A
E
S
R
R
E
D
L
E
S
Y
L
G
Q
R
Y
P
A
S
D
I
P
A
Q
A
R
R
L
Y
-
I
------------------------------
Q
---
N
--
P
I
R
L
-
I
A
D
V
A
Y
T
P
M
R
-
V
F
P
A
----
L
N
P
E
T
-
N
E
S
F
D
L
-
S
Y
-------
S
V
L
R
S
V
---------------
S
P
I
H
C
E
Y
L
T
N
M
G
V
R
A
S
M
S
I
S
I
V
V
G
G
K
L
W
-------------------------------------------------------------
G
L
F
S
C
H
H
-
M
S
P
K
L
I
P
Y
P
V
-
R
M
-
S
--
F
Q
I
F
S
Q
V
C
S
A
I
V
E
R
L
E
-
Q
-
G
R
I
A
E
-
L
L
R
V
S
T
E
R
R
L
A
L
A
-----
R
R
A
R
D
A
D
D
L
F
G
A
-
L
A
H
P
D
D
G
I
A
---
A
L
I
P
C
D
-------------------------------------------------------
G
A
L
V
M
L
-----------------
G
G
R
T
L
S
I
R
G
D
---
F
E
R
Q
A
G
N
V
L
Q
R
L
Q
R
D
P
E
R
D
I
Y
H
T
D
N
W
C
C
G
V
L
A
I
R
F
H
R
Q
E
S
------------
G
W
I
F
W
F
R
H
E
E
V
H
R
I
R
W
G
G
K
P
E
K
L
L
T
I
G
P
S
--
G
P
R
L
T
P
R
G
S
F
E
A
W
E
E
V
V
R
G
H
S
T
---
P
W
-----
S
E
T
D
L
A
I
A
E
K
L
R
L
D
L
M
E
L
C
L
8
PsiBlast_PDB
41.85
31%
81
- C6 -
4ND9
-
?
A:
[79-125]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------
K
D
----
A
A
K
G
Y
E
E
A
K
T
L
D
Y
D
A
N
K
I
V
W
L
A
P
S
P
A
N
N
T
W
A
I
A
L
R
K
D
V
A
D
K
N
N
L
K
T
L
S
D
F
G
K
Y
V
A
G
G
G
T
V
V
L
A
A
S
S
E
F
V
N
S
A
A
A
L
P
A
F
Q
T
T
Y
G
F
T
M
K
P
D
Q
L
I
T
L
S
G
G
D
T
A
A
T
I
A
A
A
A
N
Q
T
N
N
A
N
A
A
M
V
Y
G
T
D
G
G
I
A
P
S
G
L
V
V
L
E
D
D
K
H
V
Q
P
V
Y
Q
P
A
P
I
I
R
E
E
V
L
K
K
H
P
N
I
E
E
L
-----
L
K
P
V
F
E
K
L
D
L
A
T
L
Q
D
L
N
A
--
7
PsiBlast_PDB
41.01
31%
83
- C6 -
4NE4
1
?
A:
[79-125]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------
K
D
----
A
A
K
G
Y
E
E
A
K
T
L
D
Y
D
A
N
K
I
V
W
L
A
P
S
P
A
N
N
T
W
A
I
A
L
R
K
D
V
A
D
K
N
N
L
K
T
L
S
D
F
G
K
Y
V
A
G
G
G
T
V
V
L
A
A
S
S
E
F
V
N
S
A
A
A
L
P
A
F
Q
T
T
Y
G
F
T
M
K
P
D
Q
L
I
T
L
S
G
G
D
T
A
A
T
I
A
A
A
A
N
Q
T
N
N
A
N
A
A
M
V
Y
G
T
D
G
G
I
A
P
S
G
L
V
V
L
E
D
D
K
H
V
Q
P
V
Y
Q
P
A
P
I
I
R
E
E
V
L
K
K
H
P
N
I
E
E
L
-----
L
K
P
V
F
E
K
L
D
L
A
T
L
Q
D
L
N
A
--
4
PsiBlast_PDB
37.36
43%
47
- C6 -
2QAP
-
?
A:
[269-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------
G
K
T
A
A
--------
P
E
Q
V
A
H
Y
T
V
M
T
L
A
R
T
M
P
-
A
M
L
P
G
V
M
F
----
L
S
G
G
L
S
--
E
V
-
Q
A
-
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
F
L
S
-
F
-
S
Y
A
R
A
-
L
Q
S
S
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
R
A
F
L
H
R
A
R
M
N
-
S
M
A
Q
L
G
K
Y
K
---
R
S
D
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
36.93
15%
-97
- C6 -
3L1L
2
ADIC_ECO57
A:
[7-169]
---------------------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
-
L
P
A
N
L
A
S
-
T
---
G
---------
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
-
L
G
L
S
M
V
Y
A
K
M
---
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
-----
L
-
G
Y
Q
T
N
V
L
Y
W
-
L
A
C
W
I
-
G
N
-
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
-----
L
KD
P
W
V
--
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
--
V
Q
A
V
A
T
V
L
A
L
I
-
P
I
V
G
I
A
V
F
G
W
F
W
F
R
--
G
E
------
T
Y
M
A
A
I
Q
S
---
T
--
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
-
V
A
A
G
----
V
V
K
N
P
-
K
R
N
V
P
I
-
A
T
I
G
-
G
V
L
I
A
A
V
C
Y
V
L
S
--------
T
T
A
I
M
G
M
I
P
N
A
A
L
R
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
------
A
A
G
C
---------
L
G
S
L
G
--------
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
-
L
-
F
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
--
A
G
-
L
I
-
I
--
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
-
A
-
T
K
E
F
G
-
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
-
K
A
R
P
A
Y
L
A
V
---
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
---------
W
-------
S
F
----
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
36.73
43%
29
- C6 -
2QDG
1
?
A:
[269-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------
G
K
T
A
A
--------
P
E
Q
V
A
H
Y
T
V
M
T
L
A
R
T
M
P
-
A
M
L
P
G
V
M
F
----
L
S
G
G
L
S
--
E
V
-
Q
A
-
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
F
L
S
-
F
-
S
Y
A
R
A
-
L
Q
S
S
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
R
A
F
L
H
R
A
R
M
N
-
S
M
A
Q
L
G
K
Y
K
---
R
S
D
D
D
A
S
S
S
S
L
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
36.57
43%
39
- C6 -
2QDH
1
?
A:
[269-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------
G
K
T
A
A
--------
P
E
Q
V
A
H
Y
T
V
M
T
L
A
R
T
M
P
-
A
M
L
P
G
V
M
F
----
L
S
G
G
L
S
--
E
V
-
Q
A
-
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
F
L
S
-
F
-
S
Y
A
R
A
-
L
Q
S
S
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
R
A
F
L
H
R
A
R
M
N
-
S
M
A
Q
L
G
K
Y
K
---
R
S
D
D
D
A
S
S
S
S
L
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
35.82
43%
42
- C6 -
1EPX
-
?
A:
[249-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------
G
K
T
A
A
--------
P
E
Q
V
A
H
Y
T
V
M
T
L
A
R
T
M
P
-
A
M
L
P
G
V
M
F
----
L
S
G
G
L
S
--
E
V
-
Q
A
-
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
F
L
S
-
F
-
S
Y
A
R
A
-
L
Q
S
S
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
R
A
F
L
H
R
A
R
M
N
-
S
M
A
Q
L
G
K
Y
K
---
R
S
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
34.12
10%
-87
- C6 -
3GIA
3
Y609_METJA
A:
[5-169]
---------------------------------------------------
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
I
F
G
V
G
A
K
I
A
---
G
---------
R
N
L
P
E
T
F
-
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
---
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
-----
I
I
T
G
A
L
S
I
L
L
W
-
M
S
Y
V
I
-
S
I
-
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
-----
P
IN
T
F
N
I
A
I
T
--
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
--
A
E
F
F
I
V
L
V
K
L
L
-
I
L
G
L
F
I
F
A
G
L
I
T
I
H
--
P
S
------
Y
V
I
P
D
L
A
P
---
S
--
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
-
Y
M
G
F
----
G
V
I
T
N
-
A
S
E
H
I
E
-
N
P
K
K
-
N
V
P
R
A
I
F
I
S
I
L
I
--------
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
------
G
F
L
L
---------
I
S
I
G
A
--------
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
-
V
-
A
Y
S
L
A
K
D
G
E
-
L
P
E
F
F
E
--
R
K
-
V
W
-
F
--
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
-
A
-
L
L
F
N
M
-
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
-
G
R
K
E
I
V
I
F
S
---
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
---------
V
-------
F
Y
----
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
29.43
40%
166
- C6 -
4H13
1
PETL_MASLA
E:
[1-32]
----------
M
I
L
G
A
V
F
Y
I
V
F
I
A
L
F
F
-
G
I
A
V
G
I
I
F
A
I
K
S
I
K
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
28.98
15%
364
- C6 -
1A93
2
B:
[1-32]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
G
M
R
R
K
N
D
T
H
Q
Q
D
-----
I
D
D
L
K
R
Q
N
A
L
L
E
Q
Q
V
R
A
L
--
21
Fugue
28.61
42%
241
- C6 -
4I7Z
1
PETL_MASLA
E:
[2-29]
-----------
I
L
G
A
V
F
Y
I
V
F
I
A
L
F
F
-
G
I
A
V
G
I
I
F
A
I
K
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
27.61
15%
147
- C6 -
2WSW
1
?
A:
[403-443]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
L
P
L
S
T
-
A
-
T
M
W
G
F
F
I
L
C
-
F
I
A
T
V
T
--
L
I
-
N
A
-
C
--
S
Y
T
L
A
M
S
T
C
R
S
M
K
E
G
A
-
D
-
P
P
L
L
V
-
R
I
G
W
S
V
L
V
G
I
I
G
I
I
L
L
A
L
G
G
L
K
P
I
Q
T
A
I
I
A
-
G
G
C
P
L
F
F
V
N
---
I
M
V
T
L
S
F
I
K
D
A
K
V
H
W
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
27.51
40%
172
- C6 -
2E74
1
PETL_MASLA
E:
[1-32]
----------
M
I
L
G
A
V
F
Y
I
V
F
I
A
L
F
F
-
G
I
A
V
G
I
I
F
A
I
K
S
I
K
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------