@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SL9A3_HUMAN: (2015-12-12 )
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.....---...100.......110.......120.......130.......140-...---......150-----------.........160.......170......--.180--.........190.......200..--.-....210.......220.......230...--....240.......250---........260.-..-----....270.......-280....----.-..290......-.300....------...310.......320.......330.......340--------.-.......350-........360.......370.......380....--...390.....----..400.......410.---.......420...-....430.....------------..440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620......-.630.....--..640.......650.......660...-.--...670...--...-.680.......690...------....700........710.......720........730.......740..-.....750.......760.......770.......780.......790.......800.......810.......820.......830..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MWGLGARGPDR
G
L
L
L
A
L
A
L
GGLARAG
G
V
EVEPGGAHGESG
G
F
Q
V
V
T
F
E
W
AHVQD
P
Y
V
I
A
L
W
I
L
V
A
S
L
A
K
I
G
F
H
L
S
H
K
V
T
S
VVP
E
S
A
L
L
I
V
L
G
L
V
L
G
---
G
I
V
W
A
A
D
H
I
A
S
F
TL
T
P
T
V
F
F
F
Y
LL
P
P
I
VLDAGYFMPN
R
L
FFG
N
L
---
G
T
I
---
L
L
Y
A
V
V
G
-------------
T
V
W
N
A
A
TT
G
L
S
L
Y
G
V
F
L
S
G
L
M
G
D
L
Q
I
G
L
--
L
D
----
F
L
L
F
G
S
L
M
A
A
V
D
P
V
A
V
L
A
V
F
E
E
VH--V-
N
E
V
L
F
I
I
V
F
G
E
S
L
L
N
D
A
V
T
V
V
L
Y
N
V
F
E
S
F
V
--ALGGDNV
T
G
V
D
C
V
K
G
I
----
V
S
F
F
V
V
S
LG
G
T
L
-
V
G
-----
V
V
F
A
F
L
L
S
L
V
T
R
F
T
-K
H
V
R
IIE----P-
G
F
V
F
I
I
S
Y
L
S
Y
-
L
T
S
E
M
L
S
L
------
S
A
I
L
A
I
T
F
C
G
I
C
C
Q
K
Y
V
K
ANISEQS
A
T
T
V
R
Y
T
M
K
M
---------
L
-ASSA
E
T
I
I
-
F
-
M
F
L
G
I
S
AVN
P
F
I
W
TW
N
T
A
F
V
L
L
T
L
V
F
I
S
V
Y
R
A
I
G
V
--
V
L
Q
T
W
L
L
N
R
Y
R
----
M
V
QLE
P
I
D
Q
V
V
L
SY-G---G
L
R
G
A
V
A
F
A
L
V
V
L
-LDGDKVKEK
N
L
F
------------
V
S
T
T
I
I
V
V
F
F
T
V
I
FQGL
T
I
K
P
L
V
Q
W
L
K
V
K
R
SEHREPRLN
E
K
LH
G
R
A
F
D
H
I
L
S
A
I
E
D
I
S
G
Q
I
G
H
N
Y
L
R
D
K
W
S
H
F
D
R
K
F
L
S
R
V
L
M
R
R
S
A
Q
K
S
R
D
R
I
L
N
V
F
H
EL
N
L
K
D
A
I
S
Y
V
A
EGERRG
S
L
A
F
I
RSPSTD
N
V
V
N
V
D
FTPRS
S
T
V
E
A
S
V
S
Y
L
L
R
EN
V
S
A
V
C
L
D
M
Q
S
L
E
Q
R
R
R
SIR
D
A
E
D
M
V
T
H
H
T
L
Q
Q
Y
L
Y
K
P
R
-
Q
E
Y
K
H
L
Y
S
R--HELTPTE
D
E
K
Q
D
R
E
I
F
H
R
T
M
R
K
R
L
E
S
F
K
-
S
--TKLGLNQ
N
K
--
K
A
A
-
K
L
Y
K
R
E
R
A
Q
K
RRNSSIP------NGKLP-MESPAQN
F
T
I
KEKDLELSDT-EEPPN
Y
D
E
E
M
S
G
G
I
E
F
L
A
S
V
T
KDT-ASDSPAGIDNPVFS
P
D
E
A
L
D
R
S
L
L
A
RLPPWLSPGETVVPSQRARTQIPYSPGT
F
C
R
LMPFRLS
S
K
S
V
D
S
F
L
QADGPEERPPAALPESTHM
34
Fugue
87.76
21%
-144
- C2 -
4CZB
-
NAH1_METJA
A:
[1-415]
---------------------------------------------------
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
A
K
I
A
E
K
L
K
--
I
P
D
I
P
L
L
L
L
L
G
L
I
I
G
PFL
Q
I
I
P
S
D
S
A
M
E
I
F
E
Y
A
G
P
I
G
L
I
F
I
L
L
G
G
A
F
T
-------------
M
---
R
I
S
---
L
L
K
R
V
I
K
-------------
T
V
V
R
L
D
T
I
T
F
-
L
I
T
L
L
I
S
G
F
I
F
N
M
V
L
N
L
--
P
Y
TS
P
V
G
Y
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
--
T
-
N
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
L
G
L
F
--
G
L
F
S
S
S
-------
N
P
L
----
I
D
L
I
T
L
A
G
G
A
I
V
-
V
G
-----
L
L
L
A
K
I
Y
E
K
I
I
I
H
C
-
D
F
H
E
Y
V
A
----
P
-
L
V
L
G
G
A
M
L
L
L
Y
-
V
G
D
D
L
L
P
S
I
CG
Y
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
-
D
D
I
D
Y
K
Y
I
V
S
F
C
D
D
---------
L
-
S
L
L
A
R
V
F
I
-
F
-
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
L
A
R
P
L
G
V
--
F
L
G
--
L
I
G
S
--------
K
H
S
F
K
E
K
L
Y
F
A
L
-
E
---
G
P
R
G
V
V
P
A
A
L
A
V
T
-
V
G
I
E
I
L
K
N
A
D
K
I
PA
S
I
T
K
Y
IT
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.01
24%
-127
- C2 -
4CZA
2
?
A:
[69-359]
-----------------------------------------------------------------------------------------------------------------------------
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
-------------
L
I
L
T
A
L
I
A
G
F
I
F
K
V
V
F
N
S
S
F
-------
L
--
L
G
----
F
L
-
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
-
K
Q
D
I
E
T
V
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
VP
G
Y
G
G
G
I
F
S
T
L
S
E
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
-----
I
---
F
L
G
I
L
G
Y
K
F
I
-
K
R
T
G
I
F
D
FP
E
I
E
-
A
F
S
L
S
L
A
F
L
G
F
-
F
I
G
E
R
L
D
A
------
S
G
Y
L
V
A
T
V
T
G
I
V
L
G
N
Y
K
L
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
D
T
L
-
A
A
L
A
T
I
F
I
-
F
-
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
R
P
L
A
T
LP
L
L
K
W
W
N
F
R
E
Y
L
----
F
I
A
L
E
G
P
R
G
V
V
P
S
A
-
L
---
A
S
L
P
L
S
L
A
L
K
Y
K
S
-
P
L
L
T
V
H
W
G
E
I
I
M
------------
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.35
24%
-130
- C2 -
4CZ8
3
?
A:
[69-359]
-----------------------------------------------------------------------------------------------------------------------------
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
-------------
L
I
L
T
A
L
I
A
G
F
I
F
K
V
V
F
N
S
S
F
-------
L
--
L
G
----
F
L
-
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
-
K
Q
D
I
E
T
V
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
V
P
G
Y
G
G
G
I
F
S
T
L
S
E
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
-----
I
---
F
L
G
I
L
G
Y
K
F
I
-
K
R
T
G
I
F
D
FP
E
I
E
-
A
F
S
L
S
L
A
F
L
G
F
-
F
I
G
E
R
L
D
A
------
S
G
Y
L
V
A
T
V
T
G
I
V
L
G
N
Y
K
L
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
D
T
L
-
A
A
L
A
T
I
F
I
-
F
-
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
R
P
L
A
T
LP
L
L
K
W
W
N
F
R
E
Y
L
----
F
I
A
L
E
G
P
R
G
V
V
P
S
A
-
L
---
A
S
L
P
L
S
L
A
L
K
Y
K
S
-
P
L
L
T
V
H
W
G
E
I
I
M
------------
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.27
24%
-130
- C2 -
4CZ9
-
?
A:
[69-359]
-----------------------------------------------------------------------------------------------------------------------------
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
-------------
L
I
L
T
A
L
I
A
G
F
I
F
K
V
V
F
N
S
S
F
-------
L
--
L
G
----
F
L
-
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
-
K
Q
D
I
E
T
V
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
VP
G
Y
G
G
G
I
F
S
T
L
S
E
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
-----
I
---
F
L
G
I
L
G
Y
K
F
I
-
K
R
T
G
I
F
D
F
P
E
I
E
-
A
F
S
L
S
L
A
F
L
G
F
-
F
I
G
E
R
L
D
A
------
S
G
Y
L
V
A
T
V
T
G
I
V
L
G
N
Y
K
L
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
D
T
L
-
A
A
L
A
T
I
F
I
-
F
-
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
R
P
L
A
T
L
P
L
L
K
W
W
N
F
R
E
Y
L
----
F
I
A
L
E
G
P
R
G
V
V
P
S
A
-
L
---
A
S
L
P
L
S
L
A
L
K
Y
K
S
-
P
L
L
T
V
H
W
G
E
I
I
M
------------
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.96
21%
-137
- C2 -
4BWZ
-
?
A:
[58-383]
------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
E
L
---
G
A
V
---
F
L
L
F
M
V
G
L
E
TR
L
K
D
I
L
A
V
G
K
E
A
F
L
V
A
V
L
G
V
A
L
--
P
F
L
G
G
Y
L
Y
G
L
E
I
G
F
E
T
L
P
----
A
L
F
L
G
T
A
L
V
A
T
S
V
G
I
T
A
R
V
L
Q
E
L
G
--
V
L
S
R
P
Y
S
R
I
I
L
G
A
A
V
I
D
D
V
L
G
L
I
V
------
L
A
--
C
V
N
G
V
A
E
T
G
Q
V
E
V
G
A
I
----
T
R
L
I
V
L
S
V
--
V
F
-
V
G
-----
L
A
-
V
F
L
S
T
L
I
A
R
L
P
L
E
R
L
P
V
G
S
----
P
L
G
F
A
L
A
L
G
V
G
M
A
-
A
L
A
A
S
I
G
L
------
A
P
I
V
G
A
F
L
G
G
M
L
L
-----------
S
E
V
R
E
K
Y
R
L
E
E
---------
P
-
I
F
A
I
E
S
F
L
-
A
P
I
F
F
A
M
V
G
V
R
L
E
L
S
A
L
A
S
P
V
V
L
V
A
G
T
V
V
T
V
I
A
I
L
G
K
--
V
L
G
G
F
L
G
A
L
T
Q
----
G
V
R
------
S
A
L
T
V
-
G
C
G
M
A
P
R
G
E
V
G
L
I
V
A
A
L
G
L
K
A
G
A
V
N
E
E
E
Y
--------------
A
I
V
L
F
M
V
V
F
T
T
L
F
A
P
F
A
L
K
P
L
I
A
W
T
E
R
E
R
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
53.65
25%
114
- C2 -
3TQ6
3
TFAM_HUMAN
A:
[41-187]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
R
I
A
Q
R
W
R
E
L
P
D
S
K
K
K
I
-----
Y
Q
D
A
Y
R
A
E
W
Q
V
Y
K
E
E
I
S
R
F
K
E
Q
L
T
P
S
Q
I
M
S
L
E
K
E
I
M
D
K
H
L
K
R
K
A
M
T
K
K
-
K
E
L
T
L
L
G
K
P
K
R
P
--
R
S
A
Y
N
V
Y
V
A
E
R
F
Q
E
A
K
G
D
S
-
P
------
Q
E
K
L
K
T
V
K
E
N
W
K
N
L
S
D
S
E
K
E
L
Y
I
Q
H
A
K
E
D
E
T
R
Y
H
N
E
M
K
S
W
E
E
Q
M
I
E
V
G
R
K
D
-
L
L
R
R
T
I
K
K
----------------------------------------------------------------------------------
23
HHSearch
53.45
16%
-121
- C2 -
1ZCD
-
NHAA_ECOLI
A:
[61-349]
-------------------------------------------------------------------------------------------------------------------
L
W
I
N
D
A
L
M
A
V
F
F
L
L
V
G
L
E
V
K
R
E
L
M
Q
G
S
L
ASL
R
Q
A
A
F
P
V
I
A
A
I
G
G
-------------
M
I
V
P
A
L
L
Y
L
A
F
N
Y
-----------
A
-
D
P
--
I
T
----
R
E
G
W
A
I
-
P
A
A
T
D
I
A
F
A
L
G
V
L
A
L
L
G
SR
V
-
P
L
A
L
K
I
F
L
M
A
L
A
I
I
D
D
L
G
A
I
I
I
I
A
L
F
Y
T
N
D
--
L
---------
S
M
A
-
S
-------
L
G
----
V
-
A
A
-
V
A
-----
I
A
V
L
A
V
L
N
----
L
C
-
G
A
R
R
T
------
G
-
V
Y
-
I
L
V
G
V
V
L
W
-
T
A
V
L
K
S
G
V
------
H
A
T
L
A
G
V
I
V
G
F
F
I
P
L
K
E
K
H
G
R
S
--
P
A
K
R
L
E
H
V
L
H
P
---------
W
V
A
Y
L
I
L
P
L
F
A
F
-
A
N
A
G
V
S
L
Q
G
V
T
L
D
G
L
T
S
I
L
P
L
G
I
I
A
G
L
L
I
G
K
P
L
G
I
--
S
L
F
C
W
L
A
L
R
L
K
LAHL
P
E
G
T
T
Y
Q
Q
I
M
V
V
G
I
L
C
---
G
I
G
F
T
M
S
I
F
I
A
S
L
-
A
F
G
S
V
D
P
E
L
I
N
W
------------
A
K
L
G
I
L
V
G
S
I
S
S
A
V
I
G
Y
S
W
L
R
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
50.32
25%
108
- C2 -
4NNU
3
TFAM_HUMAN
A:
[74-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
R
I
A
Q
R
W
R
E
L
P
D
S
K
K
K
I
-----
Y
Q
D
A
Y
R
A
E
W
Q
V
Y
K
E
E
I
S
R
F
K
E
Q
L
T
P
S
Q
I
M
S
L
E
K
E
I
M
D
K
H
L
K
R
K
A
M
T
K
K
-
K
E
L
T
L
L
G
K
P
K
R
P
--
R
S
A
Y
N
V
Y
V
A
E
R
F
Q
E
A
K
G
D
S
-
P
------
Q
E
K
L
K
T
V
K
E
N
W
K
N
L
S
D
S
E
K
E
L
Y
I
Q
H
A
K
E
D
E
T
R
Y
H
N
E
M
K
S
W
E
E
Q
M
I
E
V
G
R
K
D
-
L
L
R
R
T
I
K
-----------------------------------------------------------------------------------
13
PsiBlast_PDB
49.12
25%
115
- C2 -
4NOD
2
TFAM_HUMAN
A:
[74-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
R
I
A
Q
R
W
R
E
L
P
D
S
K
K
K
I
-----
Y
Q
D
A
Y
R
A
E
W
Q
V
Y
K
E
E
I
S
R
F
K
E
Q
L
T
P
S
Q
I
M
S
L
E
K
E
I
M
D
K
H
L
K
R
K
A
M
T
K
K
-
K
E
L
T
L
L
G
K
P
K
R
P
--
R
S
A
Y
N
V
Y
V
A
E
R
F
Q
E
A
K
G
D
S
-
P
------
Q
E
K
L
K
T
V
K
E
N
W
K
N
L
S
D
S
E
K
E
L
Y
I
Q
H
A
K
E
D
E
T
R
Y
H
N
E
M
K
S
W
E
E
Q
M
I
E
V
G
R
K
D
-
L
L
R
R
--------------------------------------------------------------------------------------
17
PsiBlast_PDB
44.55
32%
-46
* C3 *
3GZ9
2
PPARD_HUMAN
A:
[100-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
--
A
M
L
A
S
-------------------
L
V
N
K
D
G
L
L
-
V
A
NGS
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
-
D
---
I
I
E
----
P
-
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
-------
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
---------
L
-
Q
A
N
H
P
D
A
Q
-
Y
-
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
--
H
P
L
L
Q
E
I
Y
K
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
43.07
27%
168
- C2 -
3TMM
-
TFAM_HUMAN
A:
[39-155]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
R
I
A
Q
R
W
R
E
L
P
D
S
K
K
K
I
-----
Y
Q
D
A
Y
R
A
E
W
Q
V
Y
K
E
E
I
S
R
F
K
E
Q
L
T
P
S
Q
I
M
S
L
E
K
E
I
M
D
K
H
L
K
R
K
A
M
T
K
K
-
K
E
L
T
L
L
G
K
P
K
R
P
--
R
S
A
Y
N
V
Y
V
A
E
R
F
Q
E
A
K
G
D
S
-
P
------
Q
E
K
L
K
---------
T
V
K
E
N
W
K
N
L
S
D
S
-
E
K
E
L
Y
I
Q
H
A
K
E
D
E
T
R
Y
H
N
E
M
K
S
W
E
-
E
Q
M
I
E
V
G
R
K
D
L
L
R
R
T
I
K
K
------------------------------------------------------------------------
22
HHSearch
42.02
22%
240
- C2 -
2YGG
4
A:
[5-66]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
K
E
E
E
I
R
K
I
L
R
N
N
L
Q
K
T
R
-
Q
R
-
L
R
S
Y
N
R
--
H
T
L
V
A
D
P
Y
E
E
A
W
N
Q
M
L
L
R
R
Q
K
A
R
Q
L
E
Q
K
I
N
--
N
Y
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
40.40
22%
141
- C2 -
1JPM
-
AEEP_BACSU
A:
[154-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
F
Q
-
T
--
L
K
I
K
V
G
K
D
D
--
I
A
T
-
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
AN
Q
G
W
R
P
-
K
E
A
V
T
A
I
R
K
M
E
D
A
G
L
G
I
E
L
V
-
E
Q
P
V
H
K
D
D
--------
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
37
Fugue
40.13
19%
215
- C2 -
2YGG
4
A:
[1-66]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
A
L
S
K
D
K
E
E
E
I
R
K
I
L
R
N
N
L
Q
K
T
R
-
Q
R
L
R
S
-
Y
N
R
--
H
T
L
V
A
D
P
Y
E
E
A
W
N
Q
M
L
L
R
R
Q
K
A
R
Q
L
E
Q
K
-
I
--
N
N
Y
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
39.93
22%
150
- C2 -
1TKK
1
AEEP_BACSU
A:
[154-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
F
Q
-
T
--
L
K
I
K
V
G
K
D
D
--
I
A
T
-
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
AN
Q
G
W
R
P
-
K
E
A
V
T
A
I
R
K
M
E
D
A
G
L
G
I
E
L
V
-
E
Q
P
V
H
K
D
D
--------
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
42
Fugue
38.25
9%
57
- C1 -
4GNK
-
?
E:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
G
Q
R
D
D
L
I
A
S
I
L
S
E
V
A
P
T
P
L
D
E
L
R
G
H
K
A
L
V
K
L
R
S
R
Q
E
R
D
L
R
E
L
R
K
K
H
Q
R
K
A
V
T
L
T
R
R
L
L
D
G
L
A
Q
A
Q
A
E
G
R
C
R
L
R
-
D
E
A
K
R
Y
Q
E
F
Q
N
R
Q
V
-
Q
S
L
L
E
L
R
E
A
--
Q
V
D
A
E
A
Q
R
R
L
E
H
L
R
Q
A
L
Q
R
L
R
E
V
V
L
D
A
N
-
T
--
T
Q
F
K
R
L
K
E
M
N
E
R
E
K
-
K
E
L
Q
K
I
L
D
R
K
R
H
N
S
I
S
H
------
K
K
E
A
E
-
L
T
E
I
N
R
R
H
I
T
E
S
V
N
S
I
R
R
L
E
-
E
A
Q
K
Q
R
H
D
R
L
V
A
G
Q
Q
Q
V
L
Q
Q
L
A
E
E
-
E
P
K
L
L
A
Q
L
A
Q
E
C
Q
E
Q
R
A
R
L
P
Q
E
I
R
R
S
L
L
--------------------------------------------------------------
41
Fugue
36.84
22%
313
- C2 -
1Y66
6
?
A:
[3-52]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
W
S
E
E
V
E
R
K
L
K
E
F
V
R
R
H
Q
E
I
T
Q
E
T
L
H
-
E
--
Y
A
Q
K
L
G
L
N
Q
--
Q
A
I
-
E
Q
F
F
R
E
F
E
Q
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
35.75
32%
17
- C2 -
3OCE
1
?
A:
[170-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
A
A
F
E
-
A
K
--
G
-
R
E
F
A
T
V
I
K
I
G
R
T
Q
L
Q
D
A
V
P
I
T
L
G
Q
E
F
E
A
F
A
--
A
T
L
R
E
D
T
A
R
L
E
E
V
A
A
L
------
F
R
E
V
N
L
G
G
T
A
-
I
G
-----
T
R
I
N
A
S
H
A
Y
A
E
Q
A
I
-
V
E
L
S
Q
I
S
----
G
-
I
E
L
K
A
T
G
N
L
V
E
-
A
S
W
D
T
G
A
F
------
V
T
F
S
G
I
L
R
R
I
A
V
K
L
S
K
I
A
N
D
L
R
L
L
S
S
G
P
R
S
G
L
G
E
I
---------
R
-
L
P
A
V
Q
P
G
S
-
S
-
I
M
P
G
K
V
N
P
V
I
P
E
S
V
N
Q
V
C
Y
Q
V
I
G
N
D
L
T
V
T
M
A
A
E
S
G
--
Q
L
Q
L
N
A
F
E
P
L
I
----
V
Y
N
I
L
S
S
M
R
L
L
G
R
A
-
M
---
T
N
L
A
E
R
C
V
D
G
I
E
A
-
N
V
E
R
C
R
A
G
A
E
E
S
------------
I
S
L
A
T
A
L
V
P
V
V
G
Y
A
R
A
A
E
I
A
K
Q
A
L
A
S
G
Q
T
V
M
E
V
A
I
S
K
G
L
D
A
S
A
L
T
I
M
L
D
P
L
R
M
A
F
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
32.76
39%
338
- C2 -
2E30
-
B:
[1-43]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
L
L
A
V
K
K
K
Q
E
T
K
R
S
I
N
E
E
I
H
T
Q
F
L
D
H
L
L
T
G
I
E
D
I
C
G
H
Y
G
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
32.76
39%
338
- C2 -
2E30
-
B:
[1-43]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
L
L
A
V
K
K
K
Q
E
T
K
R
S
I
N
E
E
I
H
T
Q
F
L
D
H
L
L
T
G
I
E
D
I
C
G
H
Y
G
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------