@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SL9A5_HUMAN: (2015-12-12 )
MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTVESEEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.......-.70........80........90.-----.......100.......110.......120.---......130---...---....140.......150.......160.....--..170.......180.......190.....--.-.200.......210.......220.......230.......240.......250.......260-----------........270........----280.......290......--.------300....-...310...----------....320.......330...-....340.-......350.......360.......370---------.......380.......390--.........400..-.-..--..410....------...420.....------..430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......-650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
R
A
A
L
S
L
L
A
LPLAGAAEEPTQKPESPGEPPPGL
E
L
F
R
W
Q
W
HEVE
A
P
Y
L
V
A
L
W
I
L
V
A
S
L
A
K
I
V
F
H
L
S
R
-
K
V
T
S
L
V
P
E
S
C
L
L
I
L
L
G
L
V
L
G
G
I
V
L
-----
A
V
AKKA
E
Y
QLEPG
T
F
F
L
F
LL
P
P
I
VLDSGYF
M
---
P
S
R
L
F
F
D
N
L
---
G
A
I
---
L
T
Y
A
V
V
G
T
L
W
N
A
F
T
T
G
A
A
L
W
G
L
Q
Q
AGLV
A
P
R
V
--
Q
A
G
L
L
D
F
L
L
F
G
S
L
I
S
AV
D
P
V
A
V
L
A
V
F
E
E
VH--V-N
E
T
L
F
I
I
V
F
G
E
S
L
L
N
D
A
V
T
V
V
L
Y
K
V
C
N
S
F
V
E
MGSANV
Q
A
T
D
Y
L
K
G
V
A
S
L
F
V
V
SLG
G
A
A
V
G
L
V
F
------------
A
F
L
L
A
L
T
T
R
F
-
T
K
R
V
R
I
I
E
----
P
L
L
V
F
L
L
A
Y
A
A
Y
L
T
A
E
M
A
S
--
L
------
S
A
I
L
A
V
T
-
M
C
G
L
G
C
K
K
Y
----------
V
E
ANISHKSR
T
T
V
K
Y
T
M
K
T
L
-
A
S
C
A
E
T
V
I
-
F
M
L
L
GISAVDSSKWAWDS
G
L
V
L
G
T
L
I
F
I
L
---------
F
F
R
A
L
G
V
V
L
Q
T
W
V
L
N
QFR----LV
P
L
D
K
I
D
Q
V
V
M
SY-G-G
L
--
R
G
A
V
A
F
A
L
V
------
I
LLDRTKVPA
K
------
D
Y
F
V
A
T
T
I
V
V
V
F
F
T
V
I
VQGL
T
I
K
P
L
V
K
W
L
K
V
K
RSEHHKPT
L
N
Q
E
L
H
E
H
T
F
D
H
I
L
A
A
V
E
D
V
V
G
HHG
Y
H
Y
W
R
D
R
W
E
Q
F
D
K
K
Y
L
S
Q
L
L
M
R
R
S
A
Y
R
I
R
D
Q
I
W
D
V
Y
Y
R
L
N
I
R
D
A
I
S
F
V
DQGG
H
V
LSSTGLTLPSMPSRNS
V
A
E
T
S
V
T
N
L
L
R
ESGS
G
A
C
L
D
L
Q
V
I
D
T
V
RSGRD
R
E
D
A
V
M
H
H
L
L
CGGLYK
P
R
R
R
Y
K
A
S
C
S
R
H
F
I
S
E
D
A
Q
E
R
Q
D
K
E
V
F
Q
Q
N
M
K
R
R
L
E
S
F
K
-STKH
N
I
C
FTKSKPRPRKTGRRKKDGVANAEATNGKHRGLGFQD
T
A
A
V
I
L
T
VESEEEEEESDSSETEKEDDE
G
I
I
F
V
AR
A
T
S
E
V
L
Q
EGKVSGS
L
E
VCPSPRIIPPSPTCAEKELPWKSGQG
D
L
A
V
Y
VSSE
T
T
K
I
V
P
V
DMQTGW
N
Q
S
I
S
S
L
E
S
LASPPCNQA
P
I
L
T
CLPPHPRGTEEPQV
P
L
HLPSDPRSSFAFP
P
S
L
A
K
AGRSRSESSADL
P
Q
Q
Q
E
L
Q
P
L
MGHKDHTHLSPGTAT
S
H
W
C
I
Q
FNRGSRL
24
Fugue
90.23
22%
-132
* C3 *
4CZB
-
NAH1_METJA
A:
[1-415]
-------------------------------------------
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
A
K
I
A
E
-
K
L
K
--
I
P
D
I
P
L
L
L
L
L
G
L
I
I
G
P
F
L
Q
IIP
S
D
S
A
M
E
I
F
E
Y
A
G
P
I
G
L
I
F
I
L
L
G
G
A
F
T
M
R
I
S
L
L
K
RV
I
K
T
V
V
R
L
D
T
I
---
T
F
L
---
I
T
L
L
I
S
G
F
I
F
N
M
V
----------------
L
N
L
--
P
Y
T
S
P
V
G
Y
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
--
T
-
N
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
L
G
L
F
G
L
F
S
S
S
-------
N
P
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
------------
A
K
I
Y
E
K
I
I
I
H
-
C
D
F
H
E
Y
V
A
----
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
--
S
I
CG
Y
G
F
S
G
Y
M
A
V
A
-
I
M
G
L
Y
L
G
D
A
----------
L
F
R
A
D
D
I
D
Y
K
Y
I
V
S
F
C
-
D
D
L
-
S
L
L
A
R
V
F
I
-
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
---------
L
A
R
P
L
G
V
F
L
G
------
L
I
----
G
S
K
H
S
F
K
E
K
L
Y
F
A
L
-
E
-
G
P
--
R
G
V
V
P
A
A
L
A
V
T
V
G
I
E
I
L
K
N
A
D
K
I
P
A
S
I
T
K
Y
IT
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
86.04
19%
-137
- C3 -
4BWZ
-
?
A:
[3-386]
--------------------------------------------
G
A
E
H
L
L
E
I
F
Y
L
L
L
A
A
Q
V
C
A
F
I
F
K
R
L
N
Q
P
V
V
I
G
E
V
L
A
G
V
L
V
G
P
A
L
L
G
L
V
------
H
E
G
E
I
L
E
F
L
A
E
L
G
A
V
F
L
L
F
M
V
G
L
E
T
R
L
K
D
I
L
---
A
V
-----------
G
K
---
E
A
F
L
V
A
V
L
G
V
A
L
P
F
L
G
G
Y
L
Y
G
L
E
I
----------
G
F
E
T
L
P
A
L
F
L
G
T
A
L
V
A
T
S
V
G
I
T
A
R
V
L
Q
E
L
G
--
V
L
S
R
P
Y
S
R
I
I
L
G
A
A
V
I
D
D
V
L
G
L
I
V
L
A
C
V
N
G
V
A
E
T
G
Q
V
E
V
G
A
I
T
R
L
I
V
L
S
V
V
F
V
G
L
A
V
F
L
S
---------------------
T
L
I
A
R
L
-
P
L
E
R
L
P
V
G
----
S
P
L
G
F
A
L
A
L
G
V
G
M
A
A
L
A
A
S
I
G
L
------
A
P
I
V
G
A
F
-
L
G
G
M
L
L
-----------------
S
E
V
R
E
K
Y
R
L
E
E
P
I
F
A
I
-
E
S
F
L
A
P
I
F
-
F
A
M
V
G
V
R
L
E
L
S
A
---------
L
A
S
P
V
V
L
V
---------
A
G
T
V
V
T
V
I
A
I
L
G
K
V
L
G
G
F
----
L
G
A
L
T
Q
G
V
R
S
A
L
T
V
-
G
C
G
M
AP
R
G
E
V
G
L
I
V
A
------
A
L
G
L
K
A
G
A
V
N
E
------
E
E
Y
-
A
I
V
L
F
M
V
V
F
T
T
L
F
A
P
F
A
L
K
P
L
I
A
W
T
E
R
E
R
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.44
24%
-124
- C2 -
4CZA
2
?
A:
[26-310]
-------------------------------------------------------------------
R
-
T
G
I
S
Y
V
P
---
I
F
I
L
T
G
L
V
I
G
P
L
L
K
-----
L
I
P
R
D
L
A
H
E
I
F
D
F
V
R
-
V
F
G
L
V
I
I
L
F
T
E
G
H
N
L
---
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
L
I
L
T
A
L
I
----------
A
G
F
I
F
K
V
V
FN
S
S
F
L
L
G
F
L
-
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
-
K
Q
D
I
E
T
V
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
V
P
G
--------
Y
G
G
G
I
F
S
T
L
S
E
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
-
I
K
R
T
G
I
F
D
FP
E
I
E
A
F
S
L
S
L
A
F
L
G
F
F
I
G
E
R
L
D
--
A
------
S
G
Y
L
V
A
T
-
V
T
G
I
V
L
G
N
Y
KLLKPREN
I
R
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
-
D
T
L
-
A
A
L
A
T
I
F
I
-
F
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
---------
L
A
R
P
L
A
T
L
P
L
L
K
W
W
N
F
R
E
----
Y
L
F
I
A
L
E
G
P
R
G
V
V
P
-
S
-
A
L
--
A
S
L
P
L
S
L
A
L
------
K
Y
K
S
P
L
L
T
V
H
W
------
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.57
23%
-105
- C2 -
4CZ9
-
?
A:
[86-310]
--------------------------------------------------------------------------------------------------------------------------------
M
---
P
T
I
V
T
L
D
T
I
---
G
L
I
---
L
T
A
L
I
A
G
F
I
F
K
V
V
F
N
S
S
F
L
L
G
F
--------------------
L
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
-
K
Q
D
I
E
T
V
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
V
P
G
--------
Y
G
G
G
I
F
S
T
L
S
E
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
-
I
K
R
T
G
I
F
D
F
P
E
I
E
A
F
S
L
S
L
A
F
L
G
F
F
I
G
E
R
L
D
--
A
------
S
G
Y
L
V
A
T
-
V
T
G
I
V
L
G
N
Y
KLLKPRENIR
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
-
D
T
L
-
A
A
L
A
T
I
F
I
-
F
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
---------
L
A
R
P
L
A
T
L
P
L
L
K
W
W
N
F
R
E
----
Y
L
F
I
A
L
E
G
P
R
G
V
V
P
-
S
-
A
L
--
A
S
L
P
L
S
L
A
L
------
K
Y
K
S
P
L
L
T
V
H
W
------
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.59
23%
-111
- C2 -
4CZ8
3
?
A:
[87-310]
------------------------------------------------------------------------------------------------------------------------------------
P
T
I
V
T
L
D
T
I
---
G
L
I
---
L
T
A
L
I
A
G
F
I
F
K
V
V
F
N
S
S
F
L
L
G
F
--------------------
L
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
-
K
Q
D
I
E
T
V
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
V
P
G
--------
Y
G
G
G
I
F
S
T
L
S
E
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
-
I
K
R
T
G
I
F
D
FP
E
I
E
A
F
S
L
S
L
A
F
L
G
F
F
I
G
E
R
L
D
--
A
------
S
G
Y
L
V
A
T
-
V
T
G
I
V
L
G
N
Y
KLLKPREN
I
R
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
-
D
T
L
-
A
A
L
A
T
I
F
I
-
F
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
---------
L
A
R
P
L
A
T
L
P
L
L
K
W
W
N
F
R
E
----
Y
L
F
I
A
L
E
G
P
R
G
V
V
P
-
S
-
A
L
--
A
S
L
P
L
S
L
A
L
------
K
Y
K
S
P
L
L
T
V
H
W
------
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.75
21%
-83
- C2 -
4BWZ
-
?
A:
[148-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
L
G
A
A
V
I
D
D
V
L
G
L
I
V
L
A
C
V
N
G
V
A
E
T
G
Q
V
E
V
G
A
I
T
R
L
I
V
L
S
V
V
F
V
----
G
L
A
V
-----------------
F
L
S
T
L
I
A
R
L
P
L
E
R
L
P
V
G
S
----
P
L
-----
G
F
A
L
A
L
G
V
G
M
A
A
--
L
------
A
A
S
I
G
L
A
P
I
V
G
A
F
L
G
G
M
----------
L
L
S
E
V
R
E
K
Y
R
--
L
E
E
P
I
F
A
I
-
E
S
F
L
A
P
I
F
-
F
A
M
V
G
V
R
-
L
E
L
S
A
L
A
S
P
V
V
L
V
A
G
T
V
V
T
V
I
A
I
L
G
K
V
L
G
G
F
L
G
A
L
T
Q
G
V
R
S
A
L
T
V
G
C
G
----
M
A
P
R
G
E
V
G
L
I
V
A
A
L
-
G
----------------------
L
K
A
G
A
V
N
E
E
------
E
Y
--
A
I
V
L
F
M
V
V
F
T
T
L
F
A
P
F
A
L
K
P
L
I
A
W
T
E
R
E
R
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
57.09
17%
-101
- C3 -
1ZCD
-
NHAA_ECOLI
A:
[61-350]
--------------------------------------------------------------------------------------------------------------
L
W
I
N
D
A
L
M
A
V
F
F
L
L
V
G
L
E
V
---
K
R
E
L
M
Q
G
S
L
ASL
R
Q
A
A
F
P
V
I
A
A
I
G
G
M
I
V
P
A
L
L
Y
L
A
F
N
Y
--------------
A
-
D
P
I
T
R
E
G
W
A
I
-
P
A
A
T
D
I
A
F
A
L
G
V
L
A
L
L
G
SR
V
-
P
L
A
L
K
I
F
L
M
A
L
A
I
I
D
D
L
G
A
I
I
I
I
A
L
F
Y
T
N
D
L
---------
S
M
A
----
S
L
G
-----
V
A
A
V
A
I
A
V
------------
L
A
V
L
N
L
-----
C
G
A
-
R
R
-
T
----
G
V
Y
-
I
L
V
G
V
V
L
W
T
A
V
L
K
S
G
--
V
------
H
A
T
L
A
G
V
-
I
V
G
F
F
I
P
L
K
----------
E
K
H
G
R
S
--
P
A
K
R
L
E
H
V
L
H
P
W
V
A
Y
L
I
L
P
L
F
A
F
A
N
A
G
V
S
L
Q
G
V
T
L
D
G
L
T
S
I
L
P
L
G
I
I
A
G
L
L
---------
I
G
K
P
L
G
I
S
L
F
C
W
L
A
L
R
L
K
LAHL
P
E
G
T
T
Y
Q
Q
I
M
V
V
G
I
L
C
-
G
I
--
G
F
T
M
S
I
F
I
A
------
S
L
A
F
G
S
V
D
P
E
L
------
I
N
W
A
K
L
G
I
L
V
G
S
I
S
S
A
V
I
G
Y
S
W
L
R
V
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
38.40
28%
-7
- C2 -
4CZB
-
NAH1_METJA
A:
[123-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
--
T
-
N
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
L
G
L
F
G
L
F
S
S
S
N
P
L
I
D
-------
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
------------
A
K
I
Y
E
K
I
I
I
H
-
C
D
F
H
E
Y
V
A
----
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
--
S
------
I
C
G
Y
G
F
S
-
G
Y
M
A
V
A
I
M
G
----------
L
Y
L
G
D
A
L
F
R
A
D
D
I
D
Y
K
Y
I
V
S
-
F
C
D
D
L
S
L
L
-
A
R
V
F
I
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
---------
L
G
S
I
F
L
A
R
P
L
G
V
F
L
G
L
I
G
----
S
K
H
S
F
K
E
K
L
Y
F
A
L
E
-
G
-
P
R
--
G
V
V
P
A
A
L
A
V
------
T
V
G
I
E
I
L
K
N
A
D
------
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
38.19
24%
182
- C2 -
2QFZ
-
TB22A_HUMAN
A:
[215-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
K
M
L
E
E
L
V
S
R
I
D
E
Q
V
H
R
H
L
D
Q
H
E
V
-----------------
R
Y
L
Q
F
A
F
R
W
M
N
N
L
L
M
R
E
V
P
L
R
C
T
I
R
L
W
D
T
Y
Q
S
E
P
D
G
F
S
H
F
H
L
Y
V
C
A
A
F
L
V
R
W
R
K
E
I
L
E
E
K
D
F
Q
E
L
L
L
F
L
Q
N
L
P
T
A
H
W
D
D
E
D
I
S
L
L
L
A
E
A
Y
R
L
K
F
A
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
37.61
20%
244
- C2 -
2YGG
4
A:
[3-66]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
K
D
K
E
E
E
I
R
K
I
L
R
N
N
L
Q
K
T
R
Q
R
-
L
R
S
Y
N
R
H
T
L
V
A
D
P
Y
E
E
A
W
N
Q
M
L
L
R
R
Q
K
A
R
Q
L
E
Q
K
I
N
N
Y
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
36.70
28%
30
- C2 -
4D0A
-
NAH1_METJA
B:
[123-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
--
T
-
N
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
L
G
L
F
G
L
F
S
S
S
N
P
L
I
D
-------
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
------------
A
K
I
Y
E
K
I
I
I
H
-
C
D
F
H
E
Y
V
A
----
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
--
S
------
I
C
G
Y
G
F
S
-
G
Y
M
A
V
A
I
M
G
----------
L
Y
L
G
D
A
L
F
R
A
D
D
I
D
Y
K
Y
I
V
S
-
F
C
D
D
L
S
L
L
-
A
R
V
F
I
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
---------
L
G
S
I
F
L
A
R
P
L
G
V
F
L
G
L
I
G
----
S
K
H
S
F
K
E
K
L
Y
F
A
L
E
-
G
-
P
R
--
G
V
V
P
A
A
L
A
V
------
T
V
G
I
E
I
L
K
N
A
D
------
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
Y
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
31.30
35%
472
- C1 -
1OQY
-
RD23A_HUMAN
A:
[85-129]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
A
P
P
E
A
S
P
T
A
A
P
E
S
S
T
S
F
P
P
A
P
T
S
G
M
S
H
P
P
P
A
A
R
E
D
K
S
P
S
E
E
S
A
P
T
T
S
P
E
S
V
S
G
S
V
P
S
S
G
S
S
G
R
E
E
D
A
A
S
T
L
V
T
G
S
E
Y
E
T
M
L
T
25
Fugue
29.11
39%
377
- C2 -
2E30
-
B:
[1-43]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
L
L
A
V
K
K
K
Q
E
T
K
R
S
I
N
E
E
I
H
T
Q
F
L
D
H
L
L
T
G
I
E
D
I
C
G
H
Y
G
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
28.98
39%
377
- C2 -
2E30
-
B:
[1-43]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
L
L
A
V
K
K
K
Q
E
T
K
R
S
I
N
E
E
I
H
T
Q
F
L
D
H
L
L
T
G
I
E
D
I
C
G
H
Y
G
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
22.93
57%
444
- C2 -
2KBV
-
SL9A1_HUMAN
A:
[447-472]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
Q
F
I
I
A
Y
-
G
-
G
L
--
R
G
A
I
A
F
S
L
G
------
Y
L
L
D
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
22.48
7%
233
- C3 -
3LVG
-
CLCB_BOVIN
D:
[-101]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
D
R
L
T
Q
E
P
E
S
I
R
K
W
R
E
E
Q
R
K
R
L
Q
E
L
D
A
A
S
K
V
M
E
Q
E
W
R
E
K
A
K
K
D
L
E
E
W
N
Q
R
Q
S
E
Q
V
E
K
N
K
I
N
N
R
I
A
D
K
A
F
Y
Q
Q
P
D
A
D
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
21.42
40%
562
- C2 -
2BEC
-
B:
[14-38]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
I
N
E
E
I
H
T
Q
F
L
D
H
L
L
T
G
I
E
D
I
C
G
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
21.42
40%
562
- C2 -
2BEC
-
B:
[14-38]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
I
N
E
E
I
H
T
Q
F
L
D
H
L
L
T
G
I
E
D
I
C
G
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
21.37
39%
562
- C2 -
2BEC
-
B:
[14-38]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
I
N
E
E
I
H
T
Q
F
L
D
H
L
L
T
G
I
E
D
I
C
G
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
20.63
71%
440
- C2 -
2L0E
-
SL9A1_HUMAN
A:
[223-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
K
D
N
L
L
F
G
S
I
I
S
A
V
D
P
V
A
V
L
A
V
F
E
E
I
H
--
K
-
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------