@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SL9A6_HUMAN: (2015-12-12 )
MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.......-.100.......110.......120.......130.......140.......150.......160.......170....---...---180.......190.......200.......210.-......220.......230.......240.--......250-------......----------..260.......270........280.......290----.......--..-----300-.........310.......320...--....330...-....340...--.-...350.......360.......370.......380.-......390.-.....--.400.......410.......420.......430.......440--......--...450..-.--....460.....---..470...---------------....480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARRGWRR
A
P
L
RRGVGS
S
P
R
A
R
R
L
M
R
P
L
W
L
L
L
A
V
G
V
FDWAGASDGGGGEA
R
A
M
D
E
E
I
V
S
E
K
Q
A
E
E
S
HRQDS
A
N
L
L
I
F
I
L
L
L
T
L
T
I
L
T
I
W
L
F
K
H
R
R
A
R
F
-
L
H
E
T
G
L
A
M
I
Y
G
L
L
V
G
L
V
L
R
YGIHVPSDVN
N
V
T
L
S
C
E
VQSSP
T
T
L
L
V
T
F
D
P
E
V
F
F
N
ILL
P
P
I
I
F
YAGY
S
L
K
R
R
H
F
F
R
N
L
---
G
S
I
---
L
A
Y
A
F
L
G
T
A
I
S
C
F
V
I
G
S
I
M
Y
G
C
V
T
L
M
K
V
T
G
Q
LAG-
D
F
Y
F
T
D
C
L
L
F
G
A
I
VSATD
P
V
T
V
L
A
I
F
H
E
L
Q
--
V
D
V
E
L
Y
A
L
--------
L
F
G
E
S
V
----------
L
N
D
A
V
A
I
VLSS
S
I
V
-
A
Y
QPAGDNS
H
T
F
D
V
T
A
M
F
K
------
S
I
G
I
F
L
G--IF-----S---GSFAM
G
A
A
T
G
V
V
T
A
L
V
T
K
F
T
K
L
R
E
F
--
Q
L
L
E
T
G
L
F
F
L
-
M
S
W
S
T
F
L
L
A
E
--A-W
G
F
T
G
V
V
A
V
L
F
C
GIT
Q
A
H
Y
T
YNNLS
T
E
S
Q
H
R
T
K
Q
L
F
E
-
L
L
N
F
L
A
E
N
F
I
-
F
S
Y
M
G
--
L
T
L
F
T
FQNHVFN
P
T
F
V
V
G
A
F
V
A
I
F
L
GRAANI
Y
P
L
S
L
L
L
NLGR----RSKIG
S
--
N
F
Q
H
M
M
M
F
-
A
--
G
L
R
G
A
M
A
F
A
L
A
I---R
D
T
A
T
Y
A
R
---------------
Q
M
M
F
S
T
T
L
L
I
V
F
F
T
V
W
VFGG
G
T
T
A
M
L
S
C
L
H
I
R
VGVDS
D
Q
E
HLGVPENERRTTKAE
S
A
W
L
F
R
M
W
Y
NF
D
H
N
Y
L
K
P
L
LTHSGPPLTTTL
P
A
C
C
G
P
I
A
R
CLTS
P
Q
AY
E
N
Q
E
Q
LKDDDS
D
L
I
LNDG
D
I
S
L
T
YGDSTVNTEPATSSA
P
R
R
FMGNSS
E
D
A
L
D
R
ELAFGD
H
E
L
V
I
R
G
T
R
L
V
L
PMDDSEPP
L
N
L
LDNTRHGPA
29
Fugue
92.86
20%
-129
- C1 -
4CZB
-
NAH1_METJA
A:
[1-415]
-----------------------------------------------------------------------
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
A
K
I
A
E
K
L
K
I
P
D
I
P
L
L
L
L
L
G
L
I
I
G
P
F
L
Q
I
---
I
P
---
S
D
S
A
M
E
I
F
E
Y
A
G
P
I
G
L
I
F
I
L
L
G
G
A
F
T
--------------
M
R
I
S
L
L
K
R
V
I
---
K
T
V
---
V
R
L
D
T
I
T
F
L
I
T
L
L
I
S
G
F
I
F
N
M
V
L
N
L
P
Y
T
S
----------
P
V
G
Y
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
--
T
N
P
E
V
A
I
T
--------
L
E
A
E
S
I
----------
F
N
D
P
L
G
I
V
S
T
S
V
I
L
-
G
L
F
G
L
F
S
S
S
N
P
L
I
D
L
I
T
L
A
------
G
G
A
I
V
V
G
--
L
L
-----
L
---
A
K
I
Y
E
K
I
I
I
H
C
------
D
F
H
E
Y
V
A
P
--
L
V
L
G
G
A
M
L
L
L
-
Y
V
G
D
D
L
L
P
S
I
--
C
G
Y
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
-
D
D
I
D
Y
K
Y
I
V
S
F
C
D
-
D
L
S
L
L
A
R
V
F
I
-
F
V
F
L
G
--
A
C
I
---
K
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
--
L
G
S
I
F
L
A
R
P
L
G
V
F
L
G
L
-
I
----
G
S
K
H
S
F
--
K
E
K
L
Y
F
A
L
-
E
--
G
P
R
G
V
V
P
A
A
L
A
V
---
T
V
G
I
E
I
L
K
N
ADKIPA
S
I
T
K
Y
IT
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
76.74
13%
-98
- C2 -
3ORG
-
?
A:
[3-625]
-----------------
S
L
M
Y
L
L
R
L
V
C
F
L
T
L
L
G
V
T
A
A
L
F
I
F
A
V
D
L
A
V
H
G
L
E
E
L
R
M
K
I
S
R
L
A
G
R
F
A
G
Y
I
L
Y
V
V
S
G
V
A
L
C
L
L
S
T
F
W
C
A
V
L
-------
S
T
E
-
A
E
G
S
G
L
P
Q
M
K
S
I
L
S
G
F
--------------------------------------------
Y
D
K
M
R
S
A
L
E
L
R
V
L
F
A
K
A
L
---
G
L
I
---
C
A
I
G
---
G
G
L
P
V
G
W
E
G
P
N
V
H
I
A
C
I
I
A
H
Q
F
Y
R
L
G
V
F
K
E
L
C
T
D
R
A
L
R
L
Q
T
L
A
A
A
C
A
V
G
L
A
S
S
F
-------
G
A
P
L
G
G
V
--------
L
Y
S
I
E
T
----------
I
---------
A
S
F
Y
-
L
V
Q
A
F
W
K
G
V
L
S
A
L
S
G
A
I
V
Y
------
E
L
D
V
S
R
T
--
Q
T
-----
L
---
L
Y
A
I
L
G
A
L
M
G
V
L
G
A
L
F
I
R
C
V
R
S
I
Y
E
--
L
R
M
R
H
Y
P
-------------------
G
T
N
R
Y
F
L
V
G
V
V
A
L
F
A
S
A
L
Q
Y
P
F
P
R
A
T
I
N
D
L
F
K
A
V
T
E
-
L
I
L
M
P
I
I
K
F
I
-
L
V
A
L
S
--
I
G
L
-
P
L
P
A
G
V
F
V
P
S
F
L
I
G
A
G
F
G
R
L
Y
G
E
L
M
R
V
V
F
G
N
A
I
V
------------------
P
G
S
Y
A
V
-
V
--
G
A
A
A
F
T
A
G
V
T
R
A
---
L
S
C
A
V
I
I
F
---------------
E
V
T
G
Q
I
R
H
L
V
P
V
L
I
S
V
L
L
A
V
I
V
G
N
A
F
N
R
S
L
Y
E
T
L
V
L
M
K
H
L
P
Y
M
P
I
L
R
R
D
R
S
P
E
M
T
A
R
E
I
M
H
P
I
E
G
E
P
H
L
F
P
D
S
E
P
Q
H
I
K
G
I
L
E
K
F
P
N
R
L
V
F
P
V
I
D
A
N
G
Y
L
L
G
A
I
S
R
K
E
I
V
D
R
L
Q
H
V
-----------------
V
V
P
C
D
V
S
P
I
V
V
T
S
Y
S
L
V
R
Q
L
H
F
L
F
V
M
L
M
P
S
M
I
Y
V
T
E
R
G
K
L
V
G
I
V
E
R
E
D
V
A
Y
G
Y
S
N
------
36
Fugue
72.98
12%
-92
* C2 *
1KPK
-
CLCA_ECOLI
A:
[12-461]
Q
A
A
R
L
R
R
R
Q
L
I
R
Q
L
L
E
R
D
K
T
P
L
A
I
L
F
M
A
A
V
V
G
T
L
V
G
L
A
A
V
A
F
D
K
G
V
A
W
L
Q
N
Q
R
M
G
A
L
V
H
T
A
D
------
N
Y
P
L
L
L
T
V
A
F
L
C
S
A
V
L
A
M
F
G
Y
F
L
V
R
K
Y
A
P
E
-
A
G
G
S
G
I
P
E
I
E
G
A
L
E
D
Q
------------
R
P
V
R
W
W
R
V
L
P
V
K
F
F
G
G
L
G
T
L
G
G
G
M
V
L
G
R
E
G
P
T
V
Q
I
G
G
N
I
G
R
M
V
L
D
I
F
R
L
K
---
G
D
E
---
A
R
H
T
L
L
A
T
G
A
A
A
G
L
A
A
A
F
----------
N
A
P
L
A
G
-
I
L
F
I
I
E
-----------------
E
M
R
P
Q
F
R
--
Y
T
L
I
S
I
K
A
--------
V
F
I
G
V
I
----------
M
S
T
I
M
Y
R
I
F
N
H
E
V
A
-
L
I
D
V
G
K
L
S
D
A
P
L
N
T
L
W
L
Y
L
------
I
L
G
I
I
F
G
--
I
F
-----
G
---
P
I
F
N
K
W
V
L
G
M
Q
D
L
L
H
R
V
H
G
G
N
I
T
K
W
--
V
L
M
G
G
A
I
G
G
L
-
C
G
L
L
G
F
V
A
P
A
--
T
-
S
G
-----------------
G
G
F
N
L
I
P
I
A
T
A
G
N
F
S
M
G
M
-
L
V
F
I
F
V
A
R
V
I
-
T
T
L
L
C
--
F
S
S
-
G
A
P
G
G
I
F
A
P
M
L
A
L
G
T
V
L
G
T
A
F
G
M
V
A
V
E
L
F
P
Q
Y
H
L
E
--------------------
A
G
T
-
F
--
A
I
A
G
M
G
A
L
L
A
A
S
---
I
R
A
P
L
T
G
I
---------------
I
L
V
L
E
M
T
-------------
D
N
Y
Q
L
I
L
P
M
I
I
T
G
L
G
A
T
L
L
A
Q
F
-----------------------------------------------------------------------------------------
T
G
G
K
P
L
Y
S
A
I
L
A
R
T
L
A
K
Q
E
A
E
Q
L
----------------------------------------
1
PsiBlast_PDB
71.86
27%
-109
- C1 -
4CZB
-
NAH1_METJA
A:
[123-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
--
T
N
P
E
V
A
I
T
--------
L
E
A
E
S
I
----------
F
N
D
P
L
G
I
V
S
T
S
V
I
L
-
G
------------
L
F
G
L
F
S
------
S
S
N
P
L
I
D
--
L
I
-----
T
L
A
G
G
A
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
I
H
C
D
F
H
E
Y
V
A
P
L
V
L
G
G
A
M
L
L
-
L
Y
V
G
D
D
L
L
P
S
I
C
G
-
Y
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
D
D
I
D
Y
K
Y
I
V
-
S
F
C
D
-
D
L
S
L
L
A
R
V
F
I
-
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
-
F
I
P
G
L
L
V
-
A
L
G
S
I
F
L
A
R
-----
P
L
G
V
F
L
G
L
---------
I
G
S
KH
S
F
K
E
K
L
Y
F
-
A
L
E
G
P
R
G
V
V
P
A
A
L
A
V
---
T
V
G
I
E
I
L
K
---------------
N
A
D
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.82
27%
-109
- C1 -
4D0A
-
NAH1_METJA
B:
[123-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
--
T
N
P
E
V
A
I
T
--------
L
E
A
E
S
I
----------
F
N
D
P
L
G
I
V
S
T
S
V
I
L
-
G
------------
L
F
G
L
F
S
------
S
S
N
P
L
I
D
--
L
I
-----
T
LAG
G
A
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
I
H
C
D
F
H
E
Y
VA
P
L
V
L
G
G
A
M
L
L
-
L
Y
V
G
D
D
L
L
P
S
IC
G
-
Y
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
D
D
I
D
Y
K
Y
I
V
-
S
F
C
D
-
D
L
S
L
L
A
R
V
F
I
-
F
V
F
L
G
AC
I
K
L
S
M
L
E
N
Y
-
F
I
P
G
L
L
V
-
A
L
G
S
I
F
L
A
R
-----
P
L
G
V
F
L
G
L
---------
I
G
S
KH
S
F
K
E
K
L
Y
F
-
A
LE
G
P
R
G
V
V
P
A
A
L
A
V
---
T
V
G
I
E
I
L
K
---------------
N
A
D
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
Y
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
64.66
24%
-131
- C1 -
4CZA
1
?
A:
[69-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
L
I
L
T
A
L
I
A
G
F
I
F
-----------
K
V
V
F
-
N
S
S
F
L
L
G
F
L
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
K
Q
D
I
E
T
V
--------
I
V
T
E
S
I
----------
F
N
D
P
L
G
I
V
L
T
L
I
A
I
-
S
M
L
V
P
G
Y
G
G
G
I
F
--
S
T
L
S
E
------
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
---
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
I
K
R
T
G
I
F
D
F
--
P
E
I
E
A
--
F
S
L
S
L
A
F
L
G
F
F
I
G
E
--
R
-
L
D
A
S
G
Y
L
V
A
T
V
T
G
I
V
L
G
N
Y
K
L
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
-
I
E
K
E
V
H
F
N
D
T
-
L
A
A
L
A
--
T
I
F
I
F
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
R
P
L
A
T
L
P
----
L
L
K
W
W
N
--
F
R
E
Y
L
F
I
A
-
L
--
E
G
P
R
G
V
V
P
S
A
L
A
---
S
L
P
L
S
L
A
L
---------------
K
Y
K
S
P
L
L
T
V
H
W
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.38
24%
-134
- C1 -
4CZ9
-
?
A:
[69-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
L
I
L
T
A
L
I
A
G
F
I
F
-----------
K
V
V
F
-
N
S
S
F
L
L
G
F
L
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
K
Q
D
I
E
T
V
--------
I
V
T
E
S
I
----------
F
N
D
P
L
G
I
V
L
T
L
I
A
I
-
S
M
L
V
P
G
Y
G
G
G
I
F
--
S
T
L
S
E
------
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
---
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
I
K
R
T
G
I
F
D
F
--
P
E
I
E
A
--
F
S
L
S
L
A
F
L
G
F
F
I
G
E
--
R
-
L
D
A
S
G
Y
L
V
A
T
V
T
G
I
V
L
G
N
Y
K
L
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
-
I
E
K
E
V
H
F
N
D
T
-
L
A
A
L
A
--
T
I
F
I
F
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
R
P
L
A
T
L
P
----
L
L
K
W
W
N
--
F
R
E
Y
L
F
I
A
-
L
--
E
G
P
R
G
V
V
P
S
A
L
A
---
S
L
P
L
S
L
A
L
---------------
K
Y
K
S
P
L
L
T
V
H
W
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.28
24%
-133
- C1 -
4CZ8
1
?
A:
[69-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
L
I
L
T
A
L
I
A
G
F
I
F
-----------
K
V
V
F
-
N
S
S
F
L
L
G
F
L
F
G
A
I
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
--
V
K
Q
D
I
E
T
V
--------
I
V
T
E
S
I
----------
F
N
D
P
L
G
I
V
L
T
L
I
A
I
-
S
M
L
V
P
G
Y
G
G
G
I
F
--
S
T
L
S
E
------
K
L
G
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
---
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
I
K
R
T
G
I
F
D
F
--
P
E
I
E
A
--
F
S
L
S
L
A
F
L
G
F
F
I
G
E
--
R
-
L
D
A
S
G
Y
L
V
A
T
V
T
G
I
V
L
G
N
Y
K
L
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
-
I
E
K
E
V
H
F
N
D
T
-
L
A
A
L
A
--
T
I
F
I
F
V
L
L
G
A
E
M
N
L
E
V
I
W
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
R
P
L
A
T
L
P
----
L
L
K
W
W
N
--
F
R
E
Y
L
F
I
A
-
L
--
E
G
P
R
G
V
V
P
S
A
L
A
---
S
L
P
L
S
L
A
L
---------------
K
Y
K
S
P
L
L
T
V
H
W
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
61.63
15%
-103
- C1 -
1ZCD
-
NHAA_ECOLI
A:
[60-350]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
L
W
I
N
D
A
L
M
A
V
F
F
L
L
V
G
L
E
V
K
R
E
L
M
Q
G
S
L
ASL
R
Q
A
A
F
P
V
I
A
A
I
G
G
M
I
V
P
A
L
L
Y
L
A
F
N
Y
---------------
A
-
D
P
I
T
R
E
G
W
A
I
-
P
A
A
T
D
I
A
F
A
L
G
V
L
A
L
L
G
SR
V
P
L
A
L
K
I
F
--------
L
M
A
L
A
I
----------
I
D
D
L
G
A
I
I
I
I
A
L
F
Y
-
T
N
D
L
--------
S
---
M
-------------
A
S
--
L
G
---------
V
-
A
A
V
A
I
A
V
L
A
V
L
N
---
L
C
-
G
A
R
R
T
--
G
-
V
Y
----
I
L
-
V
G
V
V
L
W
T
A
V
L
--
K
-
S
G
V
H
A
T
L
A
G
V
I
V
G
F
F
I
P
L
K
E
K
H
G
R
S
P
--
A
K
R
L
E
H
V
L
H
P
W
V
A
Y
L
I
L
P
L
F
A
F
A
N
A
G
--
V
S
L
Q
G
V
T
L
D
G
L
T
S
I
L
P
L
G
I
I
A
G
L
L
I
G
K
P
L
G
I
S
L
F
C
W
L
A
L
R
L
K
LAHL
P
E
G
T
T
Y
--
Q
Q
I
M
V
V
G
I
L
C
--
G
I
G
F
T
M
S
I
F
I
A
S
---
L
A
F
G
S
V
D
P
---------------
E
L
I
N
W
A
K
L
G
I
L
V
G
S
I
S
S
A
V
I
G
Y
S
W
L
R
V
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
52.84
23%
-48
- C1 -
4TPG
2
?
A:
[274-437]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
A
A
L
I
L
T
V
Q
T
V
F
F
F
I
F
Y
Q
Q
M
S
--
T
S
L
A
L
F
A
L
RNVDWDFQ
V
F
G
T
H
L
WTWSPAQFQA
L
N
P
I
W
I
M
V
L
S
P
V
L
A
W-------------
I
A
A
K
F
A
L
G
F
A
V
V
A
I
G
F
F
I
Y
--
G
F
-----
A
---
G
Q
F
A
V
N
G
K
T
S
-
S
W
V
M
I
W
G
Y
A
S
Y
S
L
G
--
E
L
L
V
S
G
L
G
L
A
-
M
I
-
A
R
Y
----------
F
M
M
G
A
Y
F
V
A
S
G
I
S
Q
Y
L
G
G
V
V
A
N
F
A
S
V
P
Q
D
L
V
D
P
L
Q
-
T
L
P
V
Y
T
N
L
F
N
-
K
L
G
V
A
--
A
V
V
C
T
I
I
A
L
A
V
L
P
L
M
R
R
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
49.92
23%
-56
- C1 -
4LEP
1
?
A:
[274-437]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
A
A
L
I
L
T
V
Q
T
V
F
F
F
I
F
Y
Q
Q
M
S
--
T
S
L
A
L
F
A
L
R
N
VDWDF-------WTWSPAQFQA
L
N
P
I
W
I
M
V
L
S
P
V
L
A
W
S
Y
S
W
------
D
F
S
I
A
A
K
F
A
L
G
F
A
V
V
A
I
G
F
F
I
Y
--
G
F
-----
A
---
G
Q
F
A
V
N
G
K
T
S
-
S
W
V
M
I
W
G
Y
A
S
Y
S
L
G
--
E
L
L
V
S
G
L
G
L
A
-
M
I
-
A
R
Y
---------
G
F
M
M
G
A
Y
F
V
A
S
G
I
S
Q
Y
L
G
G
V
V
A
N
F
A
S
V
P
Q
D
L
V
D
P
L
Q
-
T
L
P
V
Y
T
N
L
F
N
-
K
L
G
V
A
--
A
V
V
C
T
I
I
A
L
A
V
L
P
L
M
R
R
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
49.60
23%
-52
- C1 -
4TPH
3
?
A:
[274-437]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
A
A
L
I
L
T
V
Q
T
V
F
F
F
I
F
Y
Q
Q
M
S
--
T
S
L
A
L
F
A
L
R
NVDWDFQ
V
F
G
T
H
L
WTWSPAQFQA
L
N
P
I
W
I
M
V
L
S
P
V
L
A
W-------------
I
A
A
K
F
A
L
G
F
A
V
V
A
I
G
F
F
I
Y
--
G
F
-----
A
---
G
Q
F
A
V
N
G
K
T
S
-
S
W
V
M
I
W
G
Y
A
S
Y
S
L
G
--
E
L
L
V
S
G
L
G
L
A
-
M
I
-
A
R
------------
M
M
G
A
Y
F
V
A
S
G
I
S
Q
Y
L
G
G
V
V
A
N
F
A
S
V
P
Q
D
L
V
D
P
L
Q
-
T
L
P
V
Y
T
N
L
F
N
-
K
L
G
V
A
--
A
V
V
C
T
I
I
A
L
A
V
L
P
L
M
R
R
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
43.01
29%
-98
- C3 -
2VRS
1
SIGC_ARVS1
A:
[131-211]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
L
S
D
----
I
T
H
I
P
S
--
D
L
A
R
L
V
P
S
-
A
--
G
F
Q
A
A
-
S
F
P
V
D
V
S
F
T
R
D
S
A
T
H
A
Y
---------------
Q
A
Y
G
V
Y
S
S
S
R
V
F
T
I
T
F
P
T
G
G
D
G
T
A
N
I
R
S
L
T
V
R
T
G
I
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.18
29%
-90
* C3 *
2BT8
-
SIGC_ARVS1
A:
[246-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
L
S
D
----
I
T
---
S
--
D
L
A
R
L
V
P
S
-
A
--
G
F
Q
A
A
-
S
F
P
V
D
V
S
F
T
R
D
S
A
T
H
A
Y
---------------
Q
A
Y
G
V
Y
S
S
S
R
V
F
T
I
T
F
P
T
G
G
D
G
T
A
N
I
R
S
L
T
V
R
T
G
I
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
41.87
29%
-89
- C3 -
2BSF
-
SIGC_ARVS1
A:
[96-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
L
S
D
----
I
T
H
I
P
S
--
D
L
A
R
L
V
P
S
-
A
--
G
F
Q
A
A
-
S
F
P
V
D
V
S
F
T
R
D
S
A
T
H
A
Y
---------------
Q
A
Y
G
V
Y
S
S
S
R
V
F
T
I
T
F
P
T
G
G
D
G
T
A
N
I
R
S
L
T
V
R
T
G
I
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
41.84
29%
-91
- C3 -
2BT7
-
SIGC_ARVS1
A:
[90-170]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
L
S
D
----
I
T
H
I
P
S
--
D
L
A
R
L
V
P
S
-
A
--
G
F
Q
A
A
-
S
F
P
V
D
V
S
F
T
R
D
S
A
T
H
A
Y
---------------
Q
A
Y
G
V
Y
S
S
S
R
V
F
T
I
T
F
P
T
G
G
D
G
T
A
N
I
R
S
L
T
V
R
T
G
I
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.73
29%
-92
- C3 -
2JJL
-
SIGC_ARVS1
A:
[131-211]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
L
S
D
----
I
T
H
I
P
S
--
D
L
A
R
L
V
P
S
-
A
--
G
F
Q
A
A
-
S
F
P
V
D
V
S
F
T
R
D
S
A
T
H
A
Y
---------------
Q
A
Y
G
V
Y
S
S
S
R
V
F
T
I
T
F
P
T
G
G
D
G
T
A
N
I
R
S
L
T
V
R
T
G
I
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
38.33
18%
269
* C1 *
1NKZ
6
LHB5_RHOAC
B:
[4-36]
----------------------------------------------------------
T
A
E
Q
S
E
E
L
H
K
Y
V
I
D
G
T
R
V
F
L
G
L
A
L
V
A
H
F
L
A
F
S
A
T
P
W
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
38.29
20%
226
- C1 -
2KWY
-
A:
[1-43]
----------------------------------------
M
D
N
A
G
G
V
G
E
L
E
K
K
A
E
A
G
V
Q
G
E
L
A
E
I
K
K
I
A
E
K
K
K
D
D
V
V
K
I
L
I
E
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
36.20
39%
131
- C1 -
4G1U
-
HMUU_YERPE
A:
[183-222]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
A
V
G
V
L
T
-
Y
I
S
D
D
Q
Q
L
R
Q
F
--
S
L
W
S
M
G
S
L
G
Q
-
A
Q
W
S
T
L
L
V
A
S
--
S
-
L
I
L
P
T
C
I
L
G
L
L
Q
A
R
Q
L
N
L
L
Q
L
G
D
E
E
A
H
Y
L
G
V
N
V
R
Q
A
K
-
L
R
L
L
L
L
S
A
I
L
-
I
G
A
A
V
--
A
V
S
G
V
I
G
F
I
G
L
V
V
P
H
L
I
R
M
R
I
G
A
D
H
R
W
L
L
P
G
A
A
L
G
G
A
C
L
L
L
T
----
A
D
T
L
A
R
--
T
L
V
A
P
A
E
M
-
P
--
V
G
L
L
T
S
L
L
G
G
P
Y
---
F
L
W
L
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------