@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SL9A8_HUMAN: (2015-12-12 )
MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFTRRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.....-...90........100.......110.......120.......130.......140.......150--...---.....160.......170.......180.......190....-...200.......210..--.--....220........230.......240------.........250.......260.......270.......280.......290.--......300.......310..---.....320-.......330.......340.......350-----------.-......360-.......370.....-...380.......390.-----......400-----.......------.410......------.420-.......--------430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGE
K
M
A
E
E
ERFPNTTHE
G
F
N
V
T
L
H
T
T
L
V
V
T
T
K
L
V
LPTPGK
P
I
L
PVQTG
E
Q
A
Q
Q
E
E
QSS
G
M
T
I
F
F
S
L
L
V
L
A
I
C
I
I
L
V
H
L
L
I
R
Y
R
L
H
F-LP
E
S
V
A
V
V
S
L
G
I
L
M
G
A
V
I
K
I
I
E
F
K
K
LANW
K
E
E
EMFRP
N
M
F
F
L
L
LL
P
P
I
I
FESGYSLHKG
N
F
F
Q
N
I---G
S
I
---
T
L
F
A
V
F
G
T
A
I
S
A
F
VVGG
G
I
Y
F
LG
Q
A
D
V
I
S
KLNMTD
S
F
A
F
G
S
L
-
I
S
A
V
D
P
V
A
T
I
A
I
F
N
A
L
H
V
--
D
--
P
V
L
N
M
L
-
V
F
G
E
S
I
L
N
D
A
V
S
I
V
L
TNTA--------EGLTRKNM
S
D
V
S
G
W
Q
T
F
L
Q
A
L
D
Y
F
L
K
M
F
FGS
A
A
L
G
T
L
T
G
L
I
S
A
L
V
L
K
H
IDLRK--TPSL
E
F
G
M
M
I
I
F
A
YL
P
Y
G
L
AE---GI
S
L
S
G
I
M
-
A
I
L
F
S
G
I
V
M
S
H
YTHHN
L
S
P
V
T
Q
I
L
M
Q
Q
T
L
R
-----------
T
-
V
A
F
L
C
E
T
C
V
-
F
A
F
L
G
L
S
I
-FSFP
H
K
-
F
E
I
S
F
V
I
W
C
I
V
L
V
L
F
GR-----AVN
I
F
P
L
S
------
Y
L
L
N
F
F
R
------DHKIT
P
K
M
M
F
------
I
M
W
F-SGLRGAI--------
P
Y
A
L
S
L
H
LDLEP
M
E
K
R
QLIG
T
T
T
I
V
I
V
L
F
T
I
L
L
LGGST
M
P
L
I
R
L
MDIE
D
A
K
A
HRRNKKDVNL
S
K
T
E
KMGNT
V
E
S
E
H
L
S
E
L
T
E
E
E
Y
E
A
H
Y
I
R
R
Q
DLK
G
F
V
W
L
D
A
K
YL
N
P
F
F
T
R
RL
T
Q
E
D
LHHG
R
I
Q
M
K
T
L
T
N
K
W
Y
E
E
V
RQGPSGSE
D
D
E
QELL
33
Fugue
89.17
20%
-123
- C3 -
4CZB
-
NAH1_METJA
A:
[1-415]
-----------------------------------------------------------
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
A
K
I
A
E
K
L
K
I
P
D
I
P
L
L
L
L
L
G
L
I
I
G
P
F
L
Q
I
I
P
S
D
S
A
M
E
I
F
E
Y
A
G
-
P
I
G
L
I
F
I
L
L
G
G
A
F
T
M
R
I
S
L
L
K
R
V
I
K
T
V
V
R
L
---
D
T
I
---
T
F
L
I
T
L
L
I
S
G
F
I
F
N
M
V
L
N
L
P
Y
----------
T
S
P
V
G
Y
L
F
G
A
I
-
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
T
--
N
--
P
E
V
A
I
T
-
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
--------
L
G
L
F
G
L
F
S
S
S
--------
N
P
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
I
H
C
D
F
H
E
Y
V
A
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
S
I
C-
G
Y
G
F
S
G
Y
M
-
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
D
D
-
I
D
Y
K
Y
I
V
S
F
C
D
-----------
D
-
L
S
L
L
A
R
V
F
I
-
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
-
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
L
A
R
-----
P
L
G
V
F
L
G
--------
L
I
G
--
S
------
K
H
S
F
K
E
K
L
Y
F
------
A
L
E
---
G
P
R
G
V
V
--------
P
A
A
L
A
V
T
V
G
I
E
I
L
K
N
A
D
K
I
P
A
S
I
---------------------------------------------------------------
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
---
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
---------------------
38
Fugue
75.23
19%
-46
- C1 -
5BYH
-
?
M:
[16-473]
-
T
P
Q
L
Q
Q
A
I
R
L
L
Q
L
S
T
L
E
L
Q
Q
E
L
Q
Q
A
L
-------
E
S
N
P
L
L
E
Q
T
D
L
H
D
E
V
E
A
K
E
V
E
D
R
E
S
L
D
T
---------------------------------------------
V
E
L
P
L
D
A
S
W
D
E
-----------------
I
Y
T
A
G
T
P
S
G
N
G
V
D
Y
Q
D
----
D
E
L
---
P
V
Y
-------
Q
G
E
T
T
Q
T
L
Q
D
Y
L
W
Q
V
E
L
-
T
P
F
T
D
T
D
R
A
I
A
T
S
I
-
V
D
A
V
D
D
T
G
Y
-----------------------------------
L
T
I
Q
I
--------
E
D
I
V
D
S
I
G
D
D
E
I
G
L
E
E
V
E
A
V
L
K
R
I
Q
R
F
D
P
V
G
V
A
A
K
D
L
R
D
--
C
L
L
I
Q
L
S
Q
F
A
K
E
--
T
P
W
L
E
E
A
R
L
I
I
S
D
H
L
D
L
------------------------
L
A
N
H
D
F
R
T
L
M
R
V
T
R
-
L
K
E
E
V
L
K
-----------
E
-
A
V
N
L
I
Q
S
-
L
-
D
P
R
P
G
Q
S
I
-
Q
T
S
E
P
E
-
Y
V
I
P
D
V
L
V
R
K
V
S
G
R
W
T
V
-----
E
L
N
A
D
S
I
P
------
R
L
-
K
I
N
Q
------
Q
Y
A
A
G
N
S
A
R
N
------
D
A
D
G
-
Q
F
I
R
S
N
L
--------
Q
E
A
R
W
L
I
K
S
L
E
S
R
N
D
T
L
L
R
V
S
R
C
I
V
E
Q
Q
Q
A
F
F
E
Q
G
E
E
Y
K
P
V
--
L
A
D
I
A
Q
A
V
E
H
-----
E
S
T
I
S
R
V
T
T
A
S
S
T
A
I
R
A
L
V
K
K
L
I
A
A
E
N
P
A
K
P
L
S
D
S
K
L
T
---------------------
S
L
S
E
Q
G
I
V
A
R
R
T
V
A
K
Y
R
E
S
L
S
I
P
P
S
N
Q
R
-------
1
PsiBlast_PDB
71.86
25%
-126
- C3 -
4CZ9
-
?
A:
[39-310]
-------------------------------------------------------------------------------------------------
G
L
V
I
G
P
L
L
K
L
I
P
-
R
D
L
A
H
----
E
I
F
D
F
V
R
V
F
G
L
V
I
--
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
L
I
L
T
A
L
I
A
G
----
F
I
F
K
--
V
V
F
N
S
S
F
L
L
G
F
L
F
G
A
I
-
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
V
--
K
--
Q
D
I
E
T
V
-
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
VPGY
G
G
G
I
F
S
T
L
S
E
K
L
G
--
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
I
K
R
T
G
I
F
D
--
F
P
E
I
E
-
A
F
S
L
S
L
A
F
L
G
F
F
I
G
E
---
R
L
D
A
S
G
Y
L
-
V
A
T
V
T
G
I
V
L
G
N
Y
--
K
L
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
D
T
-
L
A
A
L
A
T
I
F
I
-
F
V
L
L
G
A
E
M
-
N
L
E
V
I
W
-
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
-----
R
P
L
A
T
L
P
L
------
L
K
W
W
N
F
R
------
E
Y
L
F
I
A
L
E
G
P
------
R
G
V
V
-
P
S
A
L
A
S
L
--------
P
L
S
L
A
L
K
Y
K
S
P
L
L
T
V
H
W
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
--------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.27
25%
-129
- C3 -
4CZ8
3
?
A:
[39-310]
-------------------------------------------------------------------------------------------------
G
L
V
I
G
P
L
L
K
L
I
P
-
R
D
L
A
H
----
E
I
F
D
F
V
R
V
F
G
L
V
I
--
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
L
I
L
T
A
L
I
A
G
----
F
I
F
K
--
V
V
F
N
S
S
F
L
L
G
F
L
F
G
A
I
-
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
V
--
K
--
Q
D
I
E
T
V
-
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
V
PGY
G
G
G
I
F
S
T
L
S
E
K
L
G
--
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
I
K
R
T
G
I
F
D
--
F
P
E
I
E
-
A
F
S
L
S
L
A
F
L
G
F
F
I
G
E
---
R
L
D
A
S
G
Y
L
-
V
A
T
V
T
G
I
V
L
G
N
Y
K
L
--
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
D
T
-
L
A
A
L
A
T
I
F
I
-
F
V
L
L
G
A
E
M
-
N
L
E
V
I
W
-
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
-----
R
P
L
A
T
L
P
L
------
L
K
W
W
N
F
R
------
E
Y
L
F
I
A
L
E
G
P
------
R
G
V
V
-
P
S
A
L
A
S
L
--------
P
L
S
L
A
L
K
Y
K
S
P
L
L
T
V
H
W
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
V
G
------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.08
25%
-127
- C3 -
4CZA
2
?
A:
[39-310]
-------------------------------------------------------------------------------------------------
G
L
V
I
G
P
L
L
K
L
I
P
-
R
D
L
A
H
----
E
I
F
D
F
V
R
V
F
G
L
V
I
--
I
L
F
T
E
G
H
N
L
S
W
R
L
L
K
K
N
M
---
P
T
I
---
V
T
L
D
T
I
G
L
I
L
T
A
L
I
A
G
----
F
I
F
K
--
V
V
F
N
S
S
F
L
L
G
F
L
F
G
A
I
-
I
G
A
T
D
P
A
T
L
I
P
L
F
R
Q
Y
R
V
--
K
--
Q
D
I
E
T
V
-
I
V
T
E
S
I
F
N
D
P
L
G
I
V
L
T
L
I
A
I
S
M
L
VPGY
G
G
G
I
F
S
T
L
S
E
K
L
G
--
I
Y
A
G
G
V
I
Y
F
L
Y
N
V
S
V
S
I
S
L
G
I
F
L
G
I
L
G
Y
K
F
I
K
R
T
G
I
F
D
--
F
P
E
I
E
-
A
F
S
L
S
L
A
F
L
G
F
F
I
G
E
---
R
L
D
A
S
G
Y
L
-
V
A
T
V
T
G
I
V
L
G
N
Y
--
K
L
L
K
P
R
E
N
I
R
I
L
K
R
L
Q
R
A
I
E
K
E
V
H
F
N
D
T
-
L
A
A
L
A
T
I
F
I
-
F
V
L
L
G
A
E
M
-
N
L
E
V
I
W
-
S
N
L
G
K
G
L
L
V
A
L
G
V
M
I
L
A
-----
R
P
L
A
T
L
P
L
------
L
K
W
W
N
F
R
------
E
Y
L
F
I
A
L
E
G
P
------
R
G
V
V
-
P
S
A
L
A
S
L
--------
P
L
S
L
A
L
K
Y
K
S
P
L
L
T
V
H
W
G
E
I
I
M
A
T
V
V
I
T
V
L
T
S
V
I
V
E
T
L
W
I
P
I
L
K
D
K
L
D
--------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.30
21%
-93
- C3 -
4CZB
-
NAH1_METJA
C:
[121-369]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
L
F
G
A
I
-
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
T
--
N
--
P
E
V
A
I
T
-
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
--------
L
G
L
F
--------
G
L
F
S
S
S
N
P
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
I
H
C
D
F
H
E
Y-
V
A
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
SIC
G
Y
G
F
S
G
Y
M
-
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
-
D
D
I
D
Y
K
Y
I
V
S
F
C
D
-----------
D
-
L
S
L
L
A
R
V
F
I
-
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
-
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
L
A
R
-----
P
L
G
V
F
----------
L
G
L
I
G
S
------
K
H
S
F
K
E
K
L
Y
F
------
A
L
---
E
G
P
R
G
V
V
--------
P
A
A
L
A
V
T
V
G
I
E
I
L
K
N
A
E
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
--------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.90
22%
-139
- C3 -
4G7S
7
COX1_THET8
A:
[26-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
T
L
Y
F
L
V
L
G
F
L
A
L
I
V
G
S
L
F
G
P
F
Q
A
L
N
Y
G
N
V
D
--
A
--
Y
P
L
L
K
R
L
L
P
F
V
Q
S
Y
Y
-----
Q
---
G
L
T
L
H
G
V
L
N
A
I
V
F
T
Q
L
F
A
Q
A
I
M
V
Y
--
L
P
A
R
E
L
N
M
R
P
N
M
---------------
G
L
M
W
L
S
W
W
-
M
A
F
I
G
L
V
V
-
F
A
L
P
L
L
-
A
N
E
A
T
V
L
Y
T
F
Y
P
P
L
K
G
H
W
A
F
Y
L
G
A
S
V
F
V
L
S
T
W
V
S
I
Y
I
V
L
D
L
W
R
R
W
K
A
A
N
P
G
K
V
T
P
L
V
T
Y
M
A
V
V
F
W
L
M
W
F
-
L
A
S
L
G
L
V
L
E
A
V
L
F
L
L
P
W
S
F
G
L
V
E
G
V
D
P
L
V
A
R
T
L
F
W
W
T
G
H
P
I
I
Y
F
W
L
L
P
A
Y
A
I
I
Y
T
I
L
P
K
Q
A
G
G
K
L
V
S
D
P
M
A
R
L
A
F
L
L
F
L
L
L
S
T
P
V
G
F
H
H
Q
F
A
D
P
G
I
D
P
T
W
K
M
I
H
S
V
L
T
L
F
V
A
V
P
S
L
M
T
A
F
T
V
A
A
S
L
E
F
A
G
R
L
R
G
G
R
G
L
F
G
W
I
R
A
L
P
W
D
N
P
A
F
V
A
P
V
L
G
L
L
G
F
I
P
G
G
A
5
PsiBlast_PDB
61.67
21%
-95
- C3 -
4D0A
-
NAH1_METJA
B:
[121-369]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
L
F
G
A
I
-
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
T
--
N
--
P
E
V
A
I
T
-
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
--------
L
G
L
F
--------
G
L
F
S
S
S
N
P
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
I
H
C
D
F
H
E
Y-
V
A
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
SIC
G
Y
G
F
S
G
Y
M
-
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
-
D
D
I
D
Y
K
Y
I
V
S
F
C
D
-----------
D
-
L
S
L
L
A
R
V
F
I
-
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
-
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
L
A
R
-----
P
L
G
V
F
----------
L
G
L
I
G
S
------
K
H
S
F
K
E
K
L
Y
F
------
A
L
---
E
G
P
R
G
V
V
--------
P
A
A
L
A
V
T
V
G
I
E
I
L
K
N
A
D
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
Y
K
P
K
-----------------------------------------------------------------------------------
17
PsiBlast_PDB
61.32
22%
-138
- C3 -
3S8G
9
COX1_THET8
A:
[26-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
T
L
Y
F
L
V
L
G
F
L
A
L
I
V
G
S
L
F
G
P
F
Q
A
L
N
Y
G
N
V
D
--
A
--
Y
P
L
L
K
R
L
L
P
F
V
Q
S
Y
Y
-----
Q
---
G
L
T
L
H
G
V
L
N
A
I
V
F
T
Q
L
F
A
Q
A
I
M
V
Y
--
L
P
A
R
E
L
N
M
R
P
N
M
---------------
G
L
M
W
L
S
W
W
-
M
A
F
I
G
L
V
V
-
F
A
L
P
L
L
-
A
N
E
A
T
V
L
Y
T
F
Y
P
P
L
K
G
H
W
A
F
Y
L
G
A
S
V
F
V
L
S
T
W
V
S
I
Y
I
V
L
D
L
W
R
R
W
K
A
A
N
P
G
K
V
T
P
L
V
T
Y
M
A
V
V
F
W
L
M
W
F
-
L
A
S
L
G
L
V
L
E
A
V
L
F
L
L
P
W
S
F
G
L
V
E
G
V
D
P
L
V
A
R
T
L
F
W
W
T
G
H
P
I
V
Y
F
W
L
L
P
A
Y
A
I
I
Y
T
I
L
P
K
Q
A
G
G
K
L
V
S
D
P
M
A
R
L
A
F
L
L
F
L
L
L
S
T
P
V
G
F
H
H
Q
F
A
D
P
G
I
D
P
T
W
K
M
I
H
S
V
L
T
L
F
V
A
V
P
S
L
M
T
A
F
T
V
A
A
S
L
E
F
A
G
R
L
R
G
G
R
G
L
F
G
W
I
R
A
L
P
W
D
N
P
A
F
V
A
P
V
L
G
L
L
G
F
I
P
G
G
A
16
PsiBlast_PDB
58.70
22%
-136
- C3 -
4GP5
9
COX1_THET8
A:
[25-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
T
L
Y
F
L
V
L
G
F
L
A
L
I
V
G
S
L
F
G
P
F
Q
A
L
N
Y
G
N
V
D
--
A
--
Y
P
L
L
K
R
L
L
P
F
V
Q
S
Y
Y
-----
Q
---
G
L
T
L
H
G
V
L
N
A
I
V
F
T
Q
L
F
A
Q
A
I
M
V
Y
--
L
P
A
R
E
L
N
M
R
P
N
M
---------------
G
L
M
W
L
S
W
W
-
M
A
F
I
G
L
V
V
-
A
A
L
P
L
L
-
A
N
E
A
T
V
L
W
T
F
Y
P
P
L
K
G
H
W
A
F
Y
L
G
A
S
V
F
V
L
S
T
W
V
S
I
Y
I
V
L
D
L
W
R
R
W
K
A
A
N
P
G
K
V
T
P
L
V
T
Y
M
A
V
V
F
W
L
M
W
F
-
L
A
S
L
G
L
V
L
E
A
V
LF
L
L
P
W
S
F
G
L
V
E
G
V
D
P
L
V
A
R
T
L
F
W
W
T
G
H
P
I
V
Y
F
W
L
L
P
A
Y
A
I
I
Y
T
I
L
P
K
Q
A
G
G
K
L
V
S
D
P
M
A
R
L
A
F
L
L
F
L
L
L
S
T
P
V
G
F
H
H
Q
F
A
D
P
G
I
D
P
T
W
K
M
I
H
S
V
L
T
L
F
V
A
V
P
S
L
M
T
A
F
T
V
A
A
S
L
E
F
A
G
R
L
R
G
G
R
G
L
F
G
W
I
R
A
L
P
W
D
N
P
A
F
V
A
P
V
L
G
L
L
G
F
I
P
G
G
A
21
HHSearch
55.47
14%
-102
- C3 -
1ZCD
-
NHAA_ECOLI
A:
[61-349]
----------------------------------------------------------------------------------------------------------------------------
L
W
I
N
D
A
L
M
A
V
F
F
L
L
V
G
L
E
V
K
R
E
L
M
Q
G
S
L
ASL
R
Q
A
A
F
P
V
I
A
A
I
G
G
M
I
V
P
A
L
L
Y
L
A
F
N
Y
---------
A
-
D
P
I
T
R
E
G
W
A
I
--
P
A
A
T
D
I
A
F
A
L
G
V
L
A
L
L
G
S
RV
P
--
L
A
L
K
I
F
-
L
M
A
L
A
I
I
D
D
L
G
A
I
I
I
I
A
L
F
--------
Y
T
N
D
L
S
----------
M
A
-------
S
L
-
G
V
-
A
A
V
A
I
A
V
L
----
A
V
L
N
L
C
G
A
R
R
---
T
G
V
Y
----
I
L
V
G
V
V
L
W
T
A
V
L
---
K
S
G
V
H
A
T
L
-
A
G
V
I
V
G
F
F
I
P
L
K
E
K
H
G
R
S
P
--
A
K
R
L
E
H
V
L
H
-----------
P
W
V
A
Y
L
I
L
P
L
F
A
F
A
N
A
G
V
S
L
-
Q
G
V
T
L
D
G
L
T
S
I
L
P
L
G
I
I
A
G
L
L
I
G
K
-----
P
L
G
I
S
L
F
C
------
W
L
A
L
R
L
K
LAHL--
P
E
G
T
T
Y
Q
Q
I
M
------
V
V
G
I
L
C
G
I
G
F
T
M
--------
S
I
F
I
A
S
L
A
F
G
S
V
D
P
E
L
I
N
W
A
K
L
G
I
L
V
G
S
I
S
S
A
V
I
G
Y
S
W
L
R
V
R
L
-------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.40
26%
-65
- C3 -
4PEM
-
?
B:
[339-464]
-------------------------------------------------------------------------------------------------------------------------------------------------
G
K
T
Y
Q
Q
P
---
G
S
A
---
I
L
N
A
W
L
T
S
M
L
K
R
T
V
V
A
A
V
P
A
P
F
G
K
W
Y
S
A
S
G
Y
E
T
T
Q
D
G
P
T
G
S
L
N
I
S
----
V
G
A
K
I
L
Y
E
A
L
Q
G
--
D
KS
P
I
P
Q
A
V
D
L
F
G
G
K
P
Q
Q
E
V
I
L
A
A
L
D
D
A
W
--------
Q
T
L
S
K
R
Y
G
N
D
V
T
G
W
K
T
P
A
M
A
L
T
F
R
A
N
N
F
F
G
V
P
Q
A
A
A
K
E
A
R
H
Q
A
E
Y
Q
N
R
G
T
E
N
D
--
M
I
V
F
S
P
T
S
G
N
R
P
V
L
A
W
D
V
V
A
P
---
G
Q
S
G
F
I
A
P
-
D
G
K
A
D
K
H
Y
D
D
Q
L
K
M
Y
E
S
F
G
R
K
S
L
W
L
T
P
Q
D
V
-----------
D
-
E
H
K
E
S
Q
E
V
L
-
Q
V
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
47.84
30%
-111
- C3 -
4DJI
-
GADC_ECOLI
A:
[327-430]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
F
A
K
M
N
K
--
N
--
G
V
P
V
T
L
-
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
--------
G
G
---
N
N
M
S
-------
F
L
I
A
L
A
L
T
V
V
I
Y
L
-
C
A
Y
F
M
L
F
I
G
Y
I
-
V
L
V
L
K
H
P
D
L
K
R
--
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
--------
L
T
S
I
M
-
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
-----------
V
-
L
A
L
P
F
I
L
Y
A
-
V
H
D
A
N
T
G
V
-
T
L
E
P
I
N
-
S
Q
N
A
P
K
G
H
F
F
L
H
P
R
A
R
S
-----
P
H
Y
I
V
M
N
D
------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
47.12
30%
-111
- C3 -
4DJK
-
GADC_ECOLI
A:
[327-430]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
F
A
K
M
N
K
--
N
--
G
V
P
V
T
L
-
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
--------
G
G
---
N
N
M
S
-------
F
L
I
A
L
A
L
T
V
V
I
Y
L
-
C
A
Y
F
M
L
F
I
G
Y
I
-
V
L
V
L
K
H
P
D
L
K
R
--
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
--------
L
T
S
I
M
-
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
-----------
V
-
L
A
L
P
F
I
L
Y
A
-
V
H
F
F
L
H
P
R
-
A
R
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
46.24
26%
-65
- C3 -
4PEL
-
?
B:
[336-461]
-------------------------------------------------------------------------------------------------------------------------------------------------
G
K
T
Y
Q
Q
P
---
G
S
A
---
I
L
N
A
W
L
T
S
M
L
K
R
T
V
V
A
A
V
P
A
P
F
G
K
W
Y
S
A
S
G
Y
E
T
T
Q
D
G
P
T
G
S
L
N
I
S
----
V
G
A
K
I
L
Y
E
A
L
Q
G
--
D
KS
P
I
P
Q
A
V
D
L
F
G
G
K
P
Q
Q
E
V
I
L
A
A
L
D
D
A
W
--------
Q
T
L
S
K
R
Y
G
N
D
V
T
G
W
K
T
P
A
M
A
L
T
F
R
A
N
N
F
F
G
V
P
Q
A
A
A
K
E
A
R
H
Q
A
E
Y
Q
N
R
G
T
E
N
D
--
M
I
V
F
S
P
T
S
G
N
R
P
V
L
A
W
D
V
V
A
P
---
G
Q
S
G
F
I
A
P
-
D
G
K
A
D
K
H
Y
D
D
Q
L
I
M
Y
E
S
F
G
R
K
S
L
W
L
T
P
Q
D
V
-----------
D
-
E
H
K
E
S
Q
E
V
L
-
Q
V
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
44.86
25%
-77
- C3 -
2CBJ
1
OGA_CLOP1
A:
[291-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
D
V
K
P
L
I
T
V
P
T
E
Y
D
T
G
A
M
-
V
S
N
G
Q
P
R
A
Y
T
R
I
F
-
A
E
T
V
--
D
--
P
S
I
E
V
M
-
W
T
G
P
G
V
V
T
N
E
I
P
L
S
D
A
Q
L
I
--------
S
G
I
Y
N
R
N
M
---
A
V
W
W
N
Y
-
P
V
T
D
Y
F
K
----
G
K
L
A
L
G
P
M
H
G
L
D
K
G
L
N
Q
Y
V
D
F
F
T
V
--
N
P
M
E
H
A
E
L
S
K
I
S
I
H
T
A
A
D
Y
S
W
---
N
M
D
N
Y
D
Y
D
-
K
A
W
N
R
A
I
D
M
L
Y
G
D
L
A
E
D
M
K
V
F
A
N
H
S
T
R
M
D
N
-----------
K
-
T
W
A
K
S
G
R
E
D
-
A
P
E
L
R
A
K
M
-
D
E
L
W
N
K
-
L
S
S
K
E
D
A
S
A
L
I
E
E
L
Y
G
E
-----
F
A
R
M
E
E
A
C
------
N
N
L
K
A
N
L
------
P
E
V
A
L
E
E
C
S
R
------
Q
L
D
E
-
L
I
T
L
A
Q
G
--------
D
K
A
S
L
D
M
I
V
A
Q
L
N
E
D
T
E
A
Y
E
S
A
K
E
I
A
Q
N
K
L
N
T
A
L
S
S
F
A
V
I
S
E
K
V
A
Q
S
F
I
Q
E
A
L
S
F
D
L
T
L
I
--------------------------------------------------------------------------------------------
13
PsiBlast_PDB
44.31
25%
-77
- C3 -
2VUR
1
OGA_CLOP1
A:
[291-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
D
V
K
P
L
I
T
V
P
T
E
Y
D
T
G
A
M
-
V
S
N
G
Q
P
R
A
Y
T
R
I
F
-
A
E
T
V
--
D
--
P
S
I
E
V
M
-
W
T
G
P
G
V
V
T
N
E
I
P
L
S
D
A
Q
L
I
--------
S
G
I
Y
N
R
N
M
---
A
V
W
W
N
Y
-
P
V
T
D
Y
F
K
----
G
K
L
A
L
G
P
M
H
G
L
D
K
G
L
N
Q
Y
V
D
F
F
T
V
--
N
P
M
E
H
A
E
L
S
K
I
S
I
H
T
A
A
D
Y
S
W
---
N
M
D
N
Y
D
Y
D
-
K
A
W
N
R
A
I
D
M
L
Y
G
D
L
A
E
D
M
K
V
F
A
N
H
S
T
R
M
D
N
-----------
K
-
T
W
A
K
S
G
R
E
D
-
A
P
E
L
R
A
K
M
-
D
E
L
W
N
K
-
L
S
S
K
E
D
A
S
A
L
I
E
E
L
Y
G
E
-----
F
A
R
M
E
E
A
C
------
N
N
L
K
A
N
L
------
P
E
V
A
L
E
E
C
S
R
------
Q
L
D
E
-
L
I
T
L
A
Q
G
--------
D
K
A
S
L
D
M
I
V
A
Q
L
N
E
D
T
E
A
Y
E
S
A
K
E
I
A
Q
N
K
L
N
T
A
L
S
S
F
A
V
I
S
E
K
V
A
Q
S
F
I
Q
E
A
L
S
F
D
L
T
L
I
--------------------------------------------------------------------------------------------
10
PsiBlast_PDB
44.19
25%
-75
- C3 -
2CBI
2
OGA_CLOP1
A:
[291-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
D
V
K
P
L
I
T
V
P
T
E
Y
D
T
G
A
M
-
V
S
N
G
Q
P
R
A
Y
T
R
I
F
-
A
E
T
V
--
D
--
P
S
I
E
V
M
-
W
T
G
P
G
V
V
T
N
E
I
P
L
S
D
A
Q
L
I
--------
S
G
I
Y
N
R
N
M
---
A
V
W
W
N
Y
-
P
V
T
D
Y
F
K
----
G
K
L
A
L
G
P
M
H
G
L
D
K
G
L
N
Q
Y
V
D
F
F
T
V
--
N
P
M
E
H
A
E
L
S
K
I
S
I
H
T
A
A
D
Y
S
W
---
N
M
D
N
Y
D
Y
D
-
K
A
W
N
R
A
I
D
M
L
Y
G
D
L
A
E
D
M
K
V
F
A
N
H
S
T
R
M
D
N
-----------
K
-
T
W
A
K
S
G
R
E
D
-
A
P
E
L
R
A
K
M
-
D
E
L
W
N
K
-
L
S
S
K
E
D
A
S
A
L
I
E
E
L
Y
G
E
-----
F
A
R
M
E
E
A
C
------
N
N
L
K
A
N
L
------
P
E
V
A
L
E
E
C
S
R
------
Q
L
D
E
-
L
I
T
L
A
Q
G
--------
D
K
A
S
L
D
M
I
V
A
Q
L
N
E
D
T
E
A
Y
E
S
A
K
E
I
A
Q
N
K
L
N
T
A
L
S
S
F
A
V
I
S
E
K
V
A
Q
S
F
I
Q
E
A
L
S
F
D
L
T
L
I
--------------------------------------------------------------------------------------------
12
PsiBlast_PDB
44.01
25%
-73
- C3 -
2V5C
-
OGA_CLOP1
A:
[291-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
D
V
K
P
L
I
T
V
P
T
E
Y
D
T
G
A
M
-
V
S
N
G
Q
P
R
A
Y
T
R
I
F
-
A
E
T
V
--
D
--
P
S
I
E
V
M
-
W
T
G
P
G
V
V
T
N
E
I
P
L
S
D
A
Q
L
I
--------
S
G
I
Y
N
R
N
M
---
A
V
W
W
N
Y
-
P
V
T
D
Y
F
K
----
G
K
L
A
L
G
P
M
H
G
L
D
K
G
L
N
Q
Y
V
D
F
F
T
V
--
N
P
M
E
H
A
E
L
S
K
I
S
I
H
T
A
A
D
Y
S
W
---
N
M
D
N
Y
D
Y
D
-
K
A
W
N
R
A
I
D
M
L
Y
G
D
L
A
E
D
M
K
V
F
A
N
H
S
T
R
M
D
N
-----------
K
-
T
W
A
K
S
G
R
E
D
-
A
P
E
L
R
A
K
M
-
D
E
L
W
N
K
-
L
S
S
K
E
D
A
S
A
L
I
E
E
L
Y
G
E
-----
F
A
R
M
E
E
A
C
------
N
N
L
K
A
N
L
------
P
E
V
A
L
E
E
C
S
R
------
Q
L
D
E
-
L
I
T
L
A
Q
G
--------
D
K
A
S
L
D
M
I
V
A
Q
L
N
E
D
T
E
A
Y
E
S
A
K
E
I
A
Q
N
K
L
N
T
A
L
S
S
F
A
V
I
S
E
K
V
A
Q
S
F
I
Q
E
A
L
S
F
D
L
T
L
I
--------------------------------------------------------------------------------------------
14
PsiBlast_PDB
43.53
25%
-82
- C3 -
2X0Y
-
OGA_CLOP1
A:
[291-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
D
V
K
P
L
I
T
V
P
T
E
Y
D
T
G
A
M
-
V
S
N
G
Q
P
R
A
Y
T
R
I
F
-
A
E
T
V
--
D
--
P
S
I
E
V
M
-
W
T
G
P
G
V
V
T
N
E
I
P
L
S
D
A
Q
L
I
--------
S
G
I
Y
N
R
N
M
---
A
V
W
W
N
Y
-
P
V
T
D
Y
F
K
----
G
K
L
A
L
G
P
M
H
G
L
D
K
G
L
N
Q
Y
V
D
F
F
T
V
--
N
P
M
E
H
A
E
L
S
K
I
S
I
H
T
A
A
D
Y
S
W
---
N
M
D
N
Y
D
Y
D
-
K
A
W
N
R
A
I
D
M
L
Y
G
D
L
A
E
D
M
K
V
F
A
N
H
S
T
R
M
D
N
-----------
K
-
T
W
A
K
S
G
R
E
D
-
A
P
E
L
R
A
K
M
-
D
E
L
W
N
K
-
L
S
S
K
E
D
A
S
A
L
I
E
E
L
Y
G
E
-----
F
A
R
M
E
E
A
C
------
N
N
L
K
A
N
L
------
P
E
V
A
L
E
E
C
S
R
------
Q
L
D
E
-
L
I
T
L
A
Q
G
--------
D
K
A
S
L
D
M
I
V
A
Q
L
N
E
D
T
E
A
Y
E
S
A
K
E
I
A
Q
N
K
L
N
T
A
L
S
S
F
A
V
I
S
E
K
V
A
Q
S
F
I
Q
E
A
L
S
F
D
L
T
L
I
--------------------------------------------------------------------------------------------