@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SL9C1_HUMAN: (2015-12-12 )
MAGIFKEFFFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFTSSQVQRYANAIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYILVLWHLASVNQLLLKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSVISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIASFLFGILSSKLIQFWMSTVFGDDVNHISLIFSILYLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFSWRWIFIMVCSEMKGMPNINMALLLAYSDLYFGSDKEKSQILFHGVLVCLITLVVNRFILPVAVTILGLRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDLANADWNMIEKAITLENPYMLNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANRRLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGPSKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMSHQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGINKLIMAKKKEVLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEEGDEPKGIYIIISGMVKLEKSKPGLGIDQMVESKEKDFPIIDTDYMLSGEIIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVIIQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTLEEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPRINLRKVRKE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230----.........240.......250--.......260.......270.......280..-.-....290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790--.......800.......810.......820----.......830..---------.....840.......850.......860.......870..-.....880....--...890.......900.......910.......920.......930.......940.......950.......-960.-........970.......980.......----990.......1000...-..-.1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
G
I
F
K
E
F
FF
S
T
E
D
L
P
E
V
I
L
T
L
S
L
I
S
S
I
G
A
F
L
N
R
H
L
EDFPI
P
V
P
V
I
L
F
L
LGCS
F
E
V
L
SF
T
S
S
Q
V
Q
R
Y
A
N
A
I
QWM
S
P
D
L
F
F
R
I
F
T
P
V
V
F
F
TTAF
D
M
D
T
Y
M
L
Q
K
L
F
W
Q
I
L
L
ISI
P
G
F
L
V
N
Y
I
L
V
L
W
H
L
A
S
V
N
Q
L
LLKP
T
Q
W
L
L
F
S
A
I
L
VSSD
P
M
L
T
A
A
A
I
R
D
LGL
S
R
S
L
I
S
L
IN
G
E
S
L
M
T
S
V
I
S
L
I
T
F
T
S
I
M
D
F
D
Q
R
L
Q
S
KRN
H
T
L
A
E
E
I
V
G
G
I
C
S
Y
I
I
A
S
F
L
F
G
I
L
S
S
K
L
I
------
Q
F
W
M
S
T
VFGDD
V
N
H
I
S
L
I
F
S
I
L
--
Y
L
I
F
Y
I
C
E
L
VGMS
G
I
F
T
L
A
I
V
G
L
L
LNS
T
S
F
K
A
-
A
-
I
E
E
T
L
L
L
E
F
W
T
F
L
S
R
I
A
F
L
M
V
F
T
F
F
G
L
L
IPA
H
T
Y
L
Y
I
E
F
V
D
I
Y
Y
S
L
N
I
Y
L
T
L
I
V
L
R
F
L
T
L
L
L
I
S
P
V
L
S
RVGHE
F
S
W
R
W
I
F
I
M
V
C
S
E
MKGMPNI
N
M
A
L
L
L
A
Y
S
D
LYFGSDK
E
K
S
Q
I
L
F
H
G
V
L
V
C
L
I
T
L
V
V
NR
F
I
L
P
V
A
V
T
I
LGLRDATST
K
Y
K
S
V
C
C
T
F
Q
H
F
Q
E
L
T
K
S
A
A
S
A
L
K
FD
K
D
LANA
D
W
N
M
I
E
K
A
ITLEN
P
Y
MLNEEETTEHQKVKCPHC
N
K
E
I
D
E
I
FN
T
E
A
M
E
L
A
N
R
R
L
L
S
A
Q
I
A
S
Y
Q
R
Q
Y
R
N
E
I
L
S
Q
S
A
V
Q
V
L
V
G
A
A
E
S
F
GEKKG
K
C
M
S
L
D
T
I
KNY
S
E
S
Q
K
T
V
T
F
A
R
K
L
L
L
N
W
V
YNTRKEKEGPSK
Y
F
F
F
R
I
C
H
T
I
V
F
T
E
E
F
E
H
V
G
Y
L
V
I
L
M
N
I
F
P
F
I
I
S
W
I
S
Q
L
N
V
I
YHSELKHTN
Y
C
F
L
T
L
Y
I
L
E
A
L
L
K
I
A
A
M
R
K
D
F
F
S
H
A
W
N
I
F
E
L
A
I
T
L
I
G
I
L
H
V
I
L
I
E
I
D
T
I
K
Y
IFNE
T
E
V
I
V
F
I
K
V
V
Q
F
F
R
I
L
R
I
F
K
L
I
A
P
K
L
L
Q
I
I
D
K
R
MSH
Q
K
T
F
W
Y
G
I
L
K
G
Y
VQGE
A
D
I
M
T
I
I
D
Q
IT
S
S
K
Q
I
K
Q
M
L
L
K
Q
V
I
R
N
M
E
H
A
I
K
ELG--YLEYDHP
E
I
A
V
T
V
K
T
K
E
E
I
N
V
M
L
N
M
A
T
E
I
L
----
K
A
FGLK
G
I
I
SKT---------EGAG
I
N
K
L
I
M
A
K
K
K
E
VLDSQSIIRPL
T
V
E
E
V
L
Y
HIPWLDK-N
K
D
Y
I
N
F
I
Q
EKA--
K
V
V
T
FDCG
N
D
I
F
EEGDEP
K
G
I
Y
I
I
IS
G
M
V
K
L
EKSKPGL
G
I
D
Q
M
V
E
SKEKDFPIIDTD
Y
M
LS
G
E
I
I
G
E
I
NCLTN-E--P-MKY
S
A
T
C
K
T
V
V
E
T
CFIP
K
T
H
L
Y
D
A
F
E
Q
C
----
S
P
L
I
K
Q
K
M
W
L
K
L
G
L
A
I
T
-
A
R
-
K
I
R
E
HLSYEDW
N
Y
N
M
Q
L
K
L
S
N
I
Y
V
V
DIPMSTKTDIYDEN
L
I
Y
V
I
L
IH
G
A
V
E
D
C
L
L
R
K
TYRA
P
F
L
I
P
I
T
C
H
Q
I
Q
S
I
E
D
F
T
K
V
V
I
I
QTPI
N
M
K
T
F
R
R
N
I
R
K
F
V
P
K
H
KSYLTPGLIG
S
V
G
T
L
E
E
G
I
Q
E
E
RNVKEDGAHSAATARSPQPCSLLGTKFNCKESPR
I
N
L
R
K
VRKE
52
Fugue
85.90
18%
-141
- C2 -
4CZB
-
NAH1_METJA
A:
[1-415]
------------
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
A
K
I
A
E
K
L
K
I
P
D
I
P
L
L
L
L
L
G
L
I
I
G
P
F
L
----
Q
I
I
P
S
D
S
A
M
E
I
F
E
Y
A
G
P
I
G
L
I
--
F
I
L
L
G
G
A
F
T
M
R
I
S
L
L
K
R
V
I
K
T
V
V
R
L
D
T
I
T
F
L
I
T
L
L
I
S
G
F
I
F
N
M
V
L
N
L
P
Y
T
S
P
V
G
Y
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
T
N
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
L
G
L
F
G
L
F
S
S
--
S
N
P
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
I
------
H
C
D
F
H
E
Y
V
A
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
S
I
C
G
Y
-
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
-
D
D
I
D
Y
K
Y
I
V
S
F
C
D
D
L
S
L
L
A
R
V
F
I
F
V
F
L
G
A
C
I
K
------
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
L
A
R
P
L
G
V
F
L
G
L
I
G
S
K
H
S
F
K
E
K
L
Y
F
A
L
E
G
P
--
R
G
V
V
P
A
A
L
A
V
T
V
G
I
E
I
L
K
N
A
D
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
69.78
17%
-24
- C3 -
3FX3
-
?
A:
[6-204]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
A
Q
K
A
I
A
R
N
S
L
L
I
R
S
L
P
E
Q
H
V
D
A
L
L
S
Q
A
--
V
W
R
S
Y
D
R
G
E
T
L
F
L
Q
E
E
K
A
Q
A
I
H
V
V
I
D
G
W
V
K
L
F
R
M
T
P
T
-------------
G
S
E
A
V
V
S
V
F
T
R
G
E
S
F
G
E
A
V
A
L
R
N
-
T
--
P
-
Y
P
V
S
A
E
A
V
T
P
C
E
V
M
H
I
P
S
P
V
F
V
S
L
M
R
R
D
-----
P
E
I
C
I
S
I
L
A
T
T
F
G
H
L
H
S
L
V
-
A
Q
L
E
Q
L
K
A
Q
T
G
A
Q
R
V
A
E
F
L
L
E
L
C
D
------------------------------------
C
E
V
T
L
P
Y
D
K
M
L
I
A
G
R
L
G
M
K
P
E
S
L
S
R
A
F
S
R
L
K
A
A
G
V
T
V
K
R
N
H
A
E
I
E
D
I
A
L
L
R
D
Y
A
E
S
-----------------------------------------------------
36
HHSearch
69.21
20%
-9
- C3 -
2PQQ
1
?
A:
[4-134]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
V
L
R
R
N
P
L
F
A
A
L
D
D
E
Q
S
A
E
L
R
A
S
M
--
S
E
V
T
L
A
R
G
D
T
L
F
H
E
G
D
P
G
D
R
L
Y
V
V
T
E
G
K
V
K
L
H
R
T
S
P
D
-------------
G
R
E
N
M
L
A
V
V
G
P
S
E
L
I
G
E
L
S
L
F
D
P
-
G
--
P
-
R
T
A
T
G
T
A
L
T
E
V
K
L
L
A
L
G
H
G
D
L
Q
P
W
L
N
V
R
-----
P
E
V
A
T
A
L
L
R
A
V
A
R
R
L
R
-
K
T
-
N
D
A
M
L
V
F
S
D
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
68.32
14%
-22
- C3 -
1Q3E
1
HCN2_MOUSE
A:
[5-197]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
S
R
R
Q
Y
Q
E
K
Y
K
Q
V
E
Q
Y
M
S
F
H
K
L
P
A
D
----
F
R
Q
K
I
H
D
Y
Y
E
H
R
---------
Y
Q
G
K
M
F
D
E
D
S
I
L
G
E
L
N
G
P
L
R
E
E
I
V
N
F
N
C
R
K
L
V
A
S
M
P
L
F
A
N
A
D
P
N
F
V
T
A
M
L
T
K
L
--
K
F
E
V
F
Q
P
G
D
Y
I
I
R
E
G
T
I
G
K
K
M
Y
F
I
Q
H
G
V
V
S
V
L
T
G
N
-------------------
K
E
M
K
L
S
D
G
S
Y
F
G
E
I
C
L
L
T
R
-
G
--
R
-
R
T
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
S
V
D
N
F
N
E
V
L
E
E
------
Y
P
M
M
R
R
A
F
E
T
V
A
I
D
R
L
-
D
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
67.20
18%
-12
- C3 -
3I54
2
CRPL_MYCTU
A:
[25-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
D
E
I
L
A
R
A
G
I
F
Q
G
V
E
P
S
A
I
A
A
-------
Q
P
V
D
F
P
R
G
H
T
V
F
A
E
G
E
P
G
D
R
L
Y
I
I
I
S
G
K
V
K
I
G
R
R
A
P
D
-------------
G
R
E
N
L
L
T
I
M
G
P
S
D
M
F
G
E
L
S
I
F
D
P
-
G
--
P
-
R
T
S
S
A
T
T
I
T
E
V
R
A
V
S
M
D
R
D
A
L
R
S
W
I
A
D
R
-----
P
E
I
S
E
Q
L
L
R
V
L
A
R
R
L
R
R
T
N
-
N
N
L
A
D
L
I
F
T
D
V
P
G
R
V
A
K
Q
L
L
Q
L
A
Q
R
F
G
T
Q
E
G
-------------------------
G
--
A
L
R
V
T
H
D
L
T
Q
E
E
I
A
Q
L
V
G
A
S
R
E
T
V
N
K
A
L
A
D
F
A
H
R
G
W
I
R
L
E
G
K
S
V
L
I
S
D
S
E
R
L
A
R
R
A
------------------------------------------------------
38
HHSearch
66.15
13%
-23
- C3 -
2PTM
2
?
A:
[12-195]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
K
Q
V
E
E
Y
M
Q
Y
R
K
L
P
S
H
L
R
N
K
I
L
D
Y
Y
----
E
Y
R
Y
R
G
K
M
---
F
---------
D
E
R
H
I
F
R
E
V
S
E
S
I
R
Q
------
D
V
A
N
Y
N
C
R
D
L
V
A
S
V
P
F
F
V
G
A
D
S
N
F
V
T
R
V
V
T
L
L
--
E
F
E
V
F
Q
P
A
D
Y
V
I
Q
E
G
T
F
G
D
R
M
F
F
I
Q
Q
G
I
V
D
I
I
M
S
D
---------------
G
--
V
I
A
T
S
L
S
D
G
S
Y
F
G
E
I
C
L
L
T
R
-
E
--
R
-
R
V
A
S
V
K
C
E
T
Y
C
T
L
F
S
L
S
V
Q
H
F
N
Q
V
L
D
E
F
-----
P
A
M
R
K
T
M
E
E
I
A
V
R
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
65.50
14%
-30
- C3 -
3BPZ
1
HCN2_MOUSE
A:
[14-196]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
K
Q
V
E
Q
Y
M
S
F
H
K
L
P
A
D
F
R
Q
K
I
H
D
Y
Y
----
E
H
R
Y
Q
G
K
M
F
D
------------
E
D
S
I
L
G
E
L
N
G
P
L
R
E
------
K
I
V
N
F
N
C
R
K
L
V
A
S
M
P
L
F
A
N
A
D
P
N
F
V
T
A
M
L
T
K
L
--
K
F
E
V
F
Q
P
G
D
Y
I
I
R
E
G
T
I
G
K
K
M
Y
F
I
Q
H
G
V
V
S
V
L
T
K
G
---------------
N
K
---
E
M
K
L
S
D
G
S
Y
F
G
E
I
C
L
L
T
R
-
G
--
R
-
R
T
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
S
V
D
N
F
N
E
V
L
E
E
Y
-----
P
M
M
R
R
A
F
E
T
V
A
I
D
R
L
D
-
R
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
65.03
18%
-18
- C3 -
3GYD
1
?
A:
[35-168]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
I
V
N
K
I
K
L
F
G
D
F
S
N
E
E
V
R
Y
L
C
S
Y
M
--
Q
C
Y
A
A
P
R
D
C
Q
L
L
T
E
G
D
P
G
D
Y
L
L
L
I
L
T
G
E
V
N
V
I
K
D
I
P
N
-------------
K
G
I
Q
T
I
A
K
V
G
A
G
A
I
I
G
E
M
S
M
I
D
G
-
M
--
P
-
R
S
A
S
C
V
A
S
L
P
T
D
F
A
V
L
S
R
D
A
L
Y
Q
L
L
A
N
M
-----
P
K
L
G
N
K
V
L
I
R
L
L
Q
L
L
T
-
A
R
-
F
R
E
S
Y
D
R
I
L
P
K
T
L
G
E
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
63.77
13%
-30
* C3 *
3E97
1
?
A:
[5-200]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
L
K
R
S
P
L
F
Q
N
V
P
E
D
A
M
R
E
A
L
K
V
V
--
T
E
R
N
F
Q
P
D
E
L
V
V
E
Q
D
A
E
G
E
A
L
H
L
V
T
T
G
V
V
R
V
S
R
V
S
L
---------------
R
E
R
V
L
G
D
I
Y
A
P
G
V
V
G
E
T
A
V
L
A
H
-
Q
--
E
-
R
S
A
S
V
R
A
L
T
P
V
R
T
L
M
L
H
R
E
H
F
E
L
I
L
R
R
H
-----
P
R
V
L
W
N
L
A
E
M
L
A
R
R
V
T
-
F
L
N
D
E
L
I
A
F
G
-
Q
N
T
E
A
A
L
T
H
V
F
A
N
L
Y
R
Q
R
L
A
A
------------------
G
V
----------
P
Q
P
E
V
L
P
L
G
T
Q
D
I
M
A
R
T
S
S
S
R
E
T
V
S
R
V
L
K
R
L
E
A
H
N
I
L
E
V
S
P
R
S
V
T
L
L
D
L
A
A
L
E
A
L
S
------------------------------------------------------
46
HHSearch
63.62
14%
-18
- C3 -
2Z69
-
?
A:
[6-139]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
Q
Q
L
L
Q
S
H
H
L
F
E
P
L
S
P
V
Q
L
Q
E
L
L
A
S
S
--
D
L
V
N
L
D
K
G
A
Y
V
F
R
Q
G
E
P
A
H
A
F
Y
Y
L
I
S
G
C
V
K
I
Y
R
L
T
P
------------------
I
L
E
V
T
N
E
R
N
T
F
A
E
A
M
M
F
M
D
-
T
--
P
N
Y
V
A
T
A
Q
A
V
V
P
S
Q
L
F
R
F
S
N
K
A
Y
L
R
Q
L
Q
D
N
-----
T
P
L
A
L
A
L
L
A
K
L
S
T
R
L
H
-
Q
R
-
I
D
E
I
E
T
L
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
63.30
19%
-5
- C3 -
3MDP
2
?
A:
[5-138]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
R
L
R
V
Y
R
F
F
A
S
L
T
D
E
Q
L
K
D
I
A
L
I
S
--
E
E
K
S
F
P
T
G
S
V
I
F
K
E
N
S
K
A
D
N
L
M
L
L
L
E
G
G
V
E
L
F
Y
S
-------------------
S
T
V
C
S
V
V
P
G
A
I
F
G
V
S
S
L
I
K
P
-
Y
--
H
-
Y
T
S
S
A
R
A
T
K
P
V
R
V
V
D
I
N
G
A
R
L
R
E
M
S
E
N
N
-----
Q
A
L
G
Q
V
L
M
N
N
V
A
A
A
V
L
-
A
R
-
L
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
62.37
13%
-17
- C3 -
3DKW
-
?
A:
[7-202]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
Q
L
L
Q
S
H
H
L
F
E
P
L
S
P
V
Q
L
Q
E
L
L
A
S
S
--
D
L
V
N
L
D
K
G
A
Y
V
F
R
Q
G
E
P
A
H
A
F
Y
Y
L
I
S
G
C
V
K
I
Y
R
L
T
P
E
-------------
G
Q
E
K
I
L
E
V
T
N
E
R
N
T
F
A
E
A
M
M
F
M
D
-
T
--
P
N
Y
V
A
T
A
Q
A
V
V
P
S
Q
L
F
R
F
S
N
K
A
Y
L
R
Q
L
Q
D
N
-----
T
P
L
A
L
A
L
L
A
K
L
S
T
R
L
H
Q
R
I
-
D
E
I
E
T
L
S
L
K
N
A
T
H
R
V
V
R
Y
L
L
T
L
A
A
H
A
-
P
G
E
-----------------------------
N
C
R
V
E
I
P
V
A
K
Q
L
V
A
G
H
L
S
I
Q
P
E
T
F
S
R
I
M
H
R
L
G
D
E
G
I
I
H
L
D
G
R
E
I
S
I
L
D
R
E
R
L
E
C
F
E
------------------------------------------------------
54
Fugue
57.92
14%
-10
- C3 -
1RGS
2
?
?:
[22-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
V
I
P
K
D
Y
K
T
M
A
A
L
A
K
A
I
E
K
N
V
L
F
S
H
L
D
D
N
E
R
S
D
I
F
D
A
M
F
P
V
S
F
I
A
G
ET
V
I
Q
Q
G
D
E
G
D
N
F
Y
V
I
D
Q
G
E
M
D
V
Y
V
N
N
E
W
A
T
S
VGEG
G
S
F
G
E
L
A
L
I
Y
G
T
PRA
A
T
V
K
A
K
T
N
V
K
L
W
G
I
D
R
D
S
Y
R
R
I
L
M
G
S
T
L
R
K
R
K
M
Y
E
E
F
L
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
T
V
A
D
A
L
--
E
P
V
Q
F
E
D
G
Q
K
I
V
V
Q
G
E
P
G
D
E
F
F
I
I
L
E
G
S
A
A
V
L
Q
R
R
S
E
N
E
E
F
V
E
V
G
R
L
G
P
------------
S
D
Y
F
G
E
I
A
L
L
M
N
-
R
--
P
-
R
A
A
T
V
V
A
R
G
P
L
K
C
V
K
L
D
R
P
R
F
E
R
V
L
G
P
C
----
S
D
I
L
K
R
N
I
Q
Q
Y
N
S
F
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
56.68
15%
-8
- C3 -
3IWZ
-
CLP_XANCP
A:
[22-212]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L
D
A
G
T
I
E
R
F
L
A
H
S
--
H
R
R
R
Y
P
T
R
T
D
V
F
R
P
G
D
P
A
G
T
L
Y
Y
V
I
S
G
S
V
S
I
I
A
E
E
D
D
-------------
D
R
E
L
V
L
G
Y
F
G
S
G
E
F
V
G
E
M
G
L
F
I
E
S
D
--
T
-
R
E
V
I
L
R
T
R
T
Q
C
E
L
A
E
I
S
Y
E
R
L
Q
Q
L
F
Q
T
S
LSPD
A
P
R
I
L
Y
A
I
G
V
Q
L
S
K
R
L
L
D
T
T
-
R
K
A
S
R
L
A
F
L
D
V
T
D
R
I
V
R
T
L
H
D
L
S
K
E
P
E
A
M
S
---------------------
H
-------
P
Q
G
T
Q
L
R
V
S
R
Q
E
L
A
R
L
V
G
C
S
R
E
M
A
G
R
V
L
K
K
L
Q
A
D
G
L
L
H
A
R
G
K
T
V
V
L
Y
G
--------------------------------------------------------------
6
PsiBlast_PDB
56.55
25%
49
- C3 -
3FX3
-
?
A:
[24-113]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
H
V
D
A
L
L
S
Q
A
--
V
W
R
S
Y
D
R
G
E
T
L
F
L
Q
E
E
K
A
Q
A
I
H
V
V
I
D
G
W
V
K
L
F
R
M
T
P
-
T
G
S
E
A
V
V
S
------------
V
F
T
R
G
E
S
F
G
E
A
V
A
L
R
N
-
T
--
P
-
Y
P
V
S
A
E
A
V
T
P
C
E
V
M
H
I
P
S
P
V
F
V
S
L
M
R
R
D
----
P
E
I
C
I
S
I
L
A
T
T
F
G
H
L
H
S
-
L
V
-
A
Q
L
E
Q
L
K
A
Q
T
G
A
Q
R
V
A
E
F
L
L
E
L
C
D
C
E
V
T
L
P
Y
D
K
M
L
I
A
G
R
L
G
M
K
P
E
S
L
S
R
A
F
S
R
L
K
A
A
G
V
T
V
K
R
N
H
A
E
I
E
D
I
A
L
L
R
D
Y
A
E
S
-----------------------------------------------------------------------------------------
47
HHSearch
55.62
10%
-36
- C3 -
1ZYB
5
?
A:
[16-211]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
D
T
L
L
Q
L
P
L
F
Q
G
L
C
H
E
D
F
T
S
I
L
D
K
V
K
L
H
F
I
K
H
K
A
G
E
T
I
I
K
S
G
N
P
C
T
Q
L
C
F
L
L
K
G
E
I
S
I
V
T
N
A
K
E
-------------
N
I
Y
T
V
I
E
Q
I
E
A
P
Y
L
I
E
P
Q
S
L
F
G
M
-
N
T-
N
-
Y
A
S
S
Y
V
A
H
T
E
V
H
T
V
C
I
S
K
A
F
V
L
S
D
L
F
R
Y
-----
D
I
F
R
L
N
Y
M
N
I
V
S
N
R
A
Q
N
L
Y
-
S
R
L
W
D
E
P
T
L
D
L
K
S
K
I
I
R
F
F
L
S
H
C
E
K
P
-
Q
--------------------------------
G
E
K
T
F
K
V
K
M
D
D
L
A
R
C
L
D
D
T
R
L
N
I
S
K
T
L
N
E
L
Q
D
N
G
L
I
E
L
H
R
K
E
I
L
I
P
D
A
Q
K
L
L
---------------------------------------------------------
44
HHSearch
55.53
13%
-16
- C3 -
2GAU
-
?
A:
[16-206]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
W
S
L
L
N
E
E
E
R
E
L
L
D
K
E
I
--
Q
P
F
P
C
K
K
A
S
T
V
F
S
E
G
D
I
P
N
N
L
F
Y
L
Y
E
G
K
I
K
I
L
R
------------------
R
F
H
I
S
R
I
V
K
P
G
Q
F
F
G
M
R
P
Y
F
A
E
-
E
--
T
-
C
S
S
T
A
I
A
V
E
N
S
K
V
L
A
I
P
V
E
A
I
E
A
L
L
K
G
N
-----
T
S
F
C
R
Y
F
L
K
A
L
A
K
E
L
G
Y
A
E
-
R
R
T
V
T
L
T
Q
K
H
V
R
G
R
L
A
E
T
L
L
I
L
K
E
N
F
G
F
E
N
---------------------
D
-------
G
A
T
L
S
I
Y
L
S
R
E
E
L
A
T
L
S
N
M
T
V
S
N
A
I
R
T
L
S
T
F
V
S
E
R
M
L
A
L
D
G
K
R
I
K
I
I
D
C
D
R
L
Q
K
T
A
R
S
G
---------------------------------------------------
35
HHSearch
55.36
15%
-19
- C3 -
2OZ6
2
VFR_PSEAE
A:
[4-190]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
L
D
K
L
L
A
H
C
--
H
R
R
R
Y
T
A
K
S
T
I
I
Y
A
G
D
R
C
E
T
L
F
F
I
I
K
G
S
V
T
I
L
I
E
D
D
D
-------------
G
R
E
M
I
I
G
Y
L
N
S
G
D
F
F
G
E
L
G
L
F
E
---Q-
E
-
R
S
A
W
V
R
A
K
V
E
C
E
V
A
E
I
S
Y
A
K
F
R
E
L
S
Q
Q
D
-----
S
E
I
L
Y
T
L
G
S
Q
M
A
D
R
L
R
K
T
T
-
R
K
V
G
D
L
A
F
L
D
V
T
G
R
V
A
R
T
L
L
D
L
C
Q
Q
P
D
A
M
T
--------------------
H
--------
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
R
I
V
G
C
S
R
E
M
V
G
R
V
L
K
S
L
E
E
Q
G
L
V
H
V
K
G
K
T
M
V
V
F
G
T
-------------------------------------------------------------
50
HHSearch
54.03
13%
-10
- C3 -
3UKN
-
?
A:
[554-739]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
T
K
D
L
K
D
F
I
R
V
H
R
L
P
K
A
L
A
Q
R
M
L
E
C
F
----
Q
T
T
W
S
V
N
N
G
--
I
---------
D
V
S
E
L
L
K
D
F
P
D
E
L
R
A
------
D
I
A
M
H
L
N
K
-
E
L
L
Q
L
P
L
F
E
S
A
S
R
G
C
L
R
S
L
S
L
I
I
--
K
T
S
F
C
A
P
G
E
F
L
I
R
Q
G
D
A
L
Q
A
I
Y
F
V
C
S
G
S
M
E
V
L
K
D
N
------------------
T
V
L
A
I
L
G
K
G
D
L
I
G
S
D
S
L
T
K
E
-
Q
V
I
K
-
T
N
A
N
V
K
A
L
T
Y
C
D
L
Q
Y
I
S
L
K
G
L
R
E
V
L
R
L
Y
-----
P
E
Y
A
Q
K
F
V
S
E
I
Q
H
D
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
53.95
20%
-99
- C2 -
4CZB
-
NAH1_METJA
A:
[69-296]
--------------------------------------------------------------------------------------
I
L
L
G
G
A
F
T
M
R
I
S
L
L
K
R
V
I
K
T
V
V
R
L
D
T
I
T
F
L
I
T
L
L
I
S
G
F
I
F
N
M
V
L
N
L
P
Y
T
S
P
V
G
Y
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
T
N
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
P
L
G
I
V
S
T
S
V
I
L
G
L
F
G
L
F
S
S
S
N
P
L
I
D
L
I
T
L
A
G
G
A
---
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
I
H
CDFH
E
Y
V
A
P
L
V
L
G
---
G
A
M
L
L
L
Y
V
G
D
--
D
L
L
P
S
I
C
G
Y
-
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
D
D
-
I
D
Y
K
Y
I
V
S
F
C
D
D
L
S
L
L
A
R
V
F
I
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
L
A
R
P
L
G
V
F
L
G
L
I
G
S
K
H
S
F
K
E
K
L
Y
F
A
L
E
G
P
R
G
V
V
P
A
A
L
A
V
T
V
G
I
E
I
L
K
N
A
D
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------