@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SL9C2_HUMAN: (2015-12-12 )
MSSYFWAQNESNRPDLLCGQPADYLVEEKHFTTLVCFIVVLGGLLKMCLKNCEVIVLTILSLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLIIFMVALDVEFYTLKKMFWQVLLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITLGIIDPLRSVNSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRGNRIHFSIFRDLHVGIELSYDILGSIIFGYWCAKIIQCILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPILMHSNYEYNWRWGVVITWSGIKGVFNLLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNATQHIQEIVQNTITLFKTEKILTNVNWTLVEDKTRIEYIPFSHVSHNDMKTESTTDEALMEEARLHVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIKKRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLTFLCSRGIIDKHEVIEINKVLLKKLKALNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAILHSLSPTFGIESNQRCDRGSRDMFTEFCTTGDIIGELSCLLKREIEYTVICETSLQACFISLEDLYEGFDAFWPSLEYKIWLKLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVETLSSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLIIQASELTQRNSNTNVMASVNTVFEQPGKNINGRQKMS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....---..120-.........130.......140.......150.......160.......170....--...180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290-.......300.-......310..-.....320.......330.......340.......350.......360.-----......370......-.380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.-------......730.......740....----...-----750.......760.......770.......780.....--..790.......800.......810.......820.......830.......840.......850.......860.......870........880.......890.......900.......910.......920.......930.......940.......950..-.-.--.-..960.......970.......980.......990.......1000......1010.....-.1020..-....1030......1040.-.-....1050......1060......1070......1080......1090......1100......1110......1120.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
Y
F
WAQNESNRPDLLCGQ
P
A
D
Y
L
V
EE
K
H
F
T
T
L
V
C
F
I
V
V
L
G
G
L
L
K
M
C
L
KNC
E
V
I
V
L
T
I
L
S
L
S
G
F
V
I
G
H
MAYNS
V
E
V
H
Q
I
V
Y
P
L
L
RTSS
F
S
L
Y
S
Y
F
S
P
L
I
I
F
M
VALD
V
E
F
Y
T
L
K
K
M
F
---
W
Q
V
---
L
L
T
G
L
I
SF
S
T
A
S
I
I
I
G
Y
V
V
I
K
FNKDS
W
D
L
Q
S
C
L
L
F
S
I
T
L
G
I
I
D
P
L
R
S
VNSLKTIG
I
--
S
K
I
Y
I
D
L
IRGE
S
L
I
I
C
S
I
A
S
I
F
FGNFRG
N
R
I
H
F
S
I
F
R
D
L
HV
G
I
E
L
S
Y
D
I
L
G
S
I
I
F
G
Y
W
C
A
K
I
I
Q
C
I
L
A
D
V
F
S
N
M
L
T
N
I
I
L
C
F
S
M
V
Y
M
T
F
Y
I
V
E
F
LGMS
G
T
L
A
L
A
A
VGLNLDSLTFK-P
K
I
E
L
V
I
T
K
F
L
-
R
I
F
S
S
V
Y
E
H
L
I
-
Y
A
F
F
G
I
V
IGCGELSH
Y
E
F
HTI
P
F
I
F
I
L
F
T
T
V
N
L
V
R
L
L
T
I
L
L
V
S
P
I
L
MHS-----N
Y
E
Y
N
W
R
W
G
V
V
I
T
WS-
G
I
K
G
V
F
N
L
LWAP
D
V
Y
N
L
A
E
R
KVE
V
P
Q
M
F
I
L
Y
V
Q
V
I
S
L
L
T
M
GI
N
S
Y
V
MTQSARK
L
D
L
C
V
L
SL
P
R
Q
M
I
L
Q
N
A
T
Q
H
I
Q
E
I
V
Q
N
T
I
T
L
F
K
T
E
K
I
LTNV
N
W
T
L
VEDKT
R
I
E
Y
I
PFSHVSHNDMKTEST
T
D
E
A
L
M
E
E
A
R
L
H
V
A
A
I
Q
M
S
S
F
E
K
QRNN
G
I
L
E
I
E
A
A
R
I
L
I
G
A
A
K
C
Y
Y
S
IQ
G
K
F
M
S
I
Y
D
V
S
T
Y
M
R
T
R
S
W
L
I
K
F
K
N
V
L
T
F
L
E
Y
C
I
E
K
I
H
F
IPPESN
T
F
L
T
F
I
F
H
I
V
FSEEFEYT
G
Q
I
I
N
L
I
Y
I
Y
P
M
I
I
H
L
W
PMARGL
N
V
S
A
L
I
S
I
N
Y
Y
F
M
F
L
Y
V
L
E
S
T
L
K
I
I
I
L
K
R
K
Y
F
Q
Q
C
W
N
T
L
E
F
F
I
L
V
I
G
I
I
D
I
F
C
V
Y
F
V
K
LRPD
N
L
A
L
I
Q
L
T
V
I
M
G
Y
L
R
I
I
R
F
L
P
L
F
K
I
I
-------
V
P
I
L
I
R
IA
D
V
Q
I
K
K
R
L
S
L
M
Y
S
I
T
----
K
G
Y
-----IKSQ
E
D
A
K
L
L
I
K
Q
I
A
V
C
E
S
I
Y
Q
K
L
C
E
I
L
ETN
K
Q
D
A
V
K
E
--
L
V
LMEHEG
R
D
V
V
I
A
LK
T
K
Q
A
I
R
N
V
I
A
K
A
L
K
N
L
T
F
L
C
SRGIID
K
H
E
V
I
E
I
N
K
V
L
L
K
K
L
K
A
L
NNFPKAIPPPTPD
I
Y
L
H
N
I
I
W
LEG-
K
D
V
L
I
D
F
F
K
E
RA
K
L
A
C
FDSGDTICKGGEMP
Q
G
I
Y
L
I
I
S
G
M
A
I
L
H
SLSPTFGIESNQRCDRG
S
R
D
M
F
T
E
FCT
T
G
D
I
I
G
E
L
S
C
L
L
-
K
-R--E-I
E
Y
T
V
I
C
E
T
S
L
Q
A
C
F
I
S
L
E
D
L
Y
E
G
F
D
A
F
WPSL
E
Y
K
I
W
L
K
L
A
L
S
T
A
Y
Q
Y
F
E
S
S
LIDE
D
L
R
F
Q
-
N
C
V
M
F
N
Q
-
A
Y
V
E
T
L
S
S
Y
S
D
M
I
IDNM
T
M
-
K
-
F
V
I
I
V
Y
GSVIDTKTEEPYFAPCIIPT
T
C
E
Q
VQ
G
T
S
D
L
S
K
L
L
I
I
Q
A
S
E
L
TQRNSNT
N
V
M
A
S
V
N
T
V
F
EQPGKNINGRQKMS
22
HHSearch
83.51
14%
-54
- C2 -
3MDP
2
?
A:
[5-138]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
R
L
R
V
Y
R
F
F
A
S
L
T
D
E
Q
L
K
D
I
A
L
I
S
E
E
K
S
F
P
T
G
S
V
I
F
K
E
N
S
K
A
D
N
L
M
L
L
L
E
G
G
V
E
L
F
Y
S
------------------
S
T
V
C
S
V
V
P
G
A
I
F
G
V
S
S
L
I
K
-
P
-
Y
--
H
-
Y
T
S
S
A
R
A
T
K
P
V
R
V
V
D
I
N
G
A
R
L
R
E
M
S
E
N
N
-
Q
A
L
G
Q
V
L
M
N
N
V
A
A
A
V
L
A
R
L
H
--------------------------------------------------------------------------------------------------------------------------
15
HHSearch
82.48
13%
-55
- C2 -
3BPZ
1
HCN2_MOUSE
A:
[15-195]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
Q
V
E
Q
Y
M
S
F
H
K
L
P
A
D
F
R
Q
K
I
H
D
Y
Y
E
H
R
Y
Q
G
K
M
F
---
D
E
D
S
I
L
G
E
L
N
G
P
L
R
E
------
K
I
V
N
F
N
C
R
K
L
V
A
S
M
P
L
F
A
N
A
D
P
N
F
V
T
A
M
L
T
K
L
K
F
E
V
F
Q
P
G
D
Y
I
I
R
E
G
T
I
G
K
K
M
Y
F
I
Q
H
G
V
V
S
V
L
T
K
G
---
N
--------------
K
E
M
K
L
S
D
G
S
Y
F
G
E
I
C
L
L
T
-
R
-
G
--
R
-
R
T
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
S
V
D
N
F
N
E
V
L
E
E
Y
-
P
M
M
R
R
A
F
E
T
V
A
I
D
R
L
D
R
I
----------------------------------------------------------------------------------------------------------------------------
11
HHSearch
82.41
20%
-46
- C2 -
2PQQ
1
?
A:
[5-133]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
R
R
N
P
L
F
A
A
L
D
D
E
Q
S
A
E
L
R
A
S
M
S
E
V
T
L
A
R
G
D
T
L
F
H
E
G
D
P
G
D
R
L
Y
V
V
T
E
G
K
V
K
L
H
R
T
S
P
-
D
G
-----------
R
E
N
M
L
A
V
V
G
P
S
E
L
I
G
E
L
S
L
F
D
-
P
-
G
--
P
-
R
T
A
T
G
T
A
L
T
E
V
K
L
L
A
L
G
H
G
D
L
Q
P
W
L
N
V
R
-
P
E
V
A
T
A
L
L
R
A
V
A
R
R
L
R
K
T
N
D
A
M
L
V
F
S
D
G
S
-----------------------------------------------------------------------------------------------------------------
10
HHSearch
81.60
13%
-51
- C2 -
2PTM
2
?
A:
[13-194]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
Q
V
E
E
Y
M
Q
Y
R
K
L
P
S
H
L
R
N
K
I
L
D
Y
Y
E
Y
R
Y
R
G
K
M
---
F
D
E
R
H
I
F
R
E
V
S
E
S
I
R
Q
------
D
V
A
N
Y
N
C
R
D
L
V
A
S
V
P
F
F
V
G
A
D
S
N
F
V
T
R
V
V
T
L
L
E
F
E
V
F
Q
P
A
D
Y
V
I
Q
E
G
T
F
G
D
R
M
F
F
I
Q
Q
G
I
V
D
I
I
M
S
D
---
G
-------------
V
I
A
T
S
L
S
D
G
S
Y
F
G
E
I
C
L
L
T
-
R
-
E
--
R
-
R
V
A
S
V
K
C
E
T
Y
C
T
L
F
S
L
S
V
Q
H
F
N
Q
V
L
D
E
F
-
P
A
M
R
K
T
M
E
E
I
A
V
R
R
L
-------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
77.81
16%
-30
- C2 -
3DN7
-
?
A:
[6-135]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
I
N
H
I
R
K
F
I
F
L
T
D
E
D
A
G
T
L
S
A
F
F
Q
L
K
K
V
R
K
K
E
T
L
L
K
T
G
E
I
C
R
I
N
Y
F
V
V
K
G
C
L
R
L
F
F
I
D
E
-
K
G
-----------
I
E
Q
T
T
Q
F
A
I
E
N
W
W
L
S
D
Y
M
A
F
Q
-
K
Q
Q
--
P
-
A
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F
Y
I
Q
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V
E
N
C
E
L
L
S
I
T
Y
T
E
Q
E
N
L
F
E
R
I
-
P
A
L
E
R
Y
F
R
L
V
Y
Q
K
S
F
A
A
A
Q
L
R
S
K
F
Q
H
M
Y
------------------------------------------------------------------------------------------------------------------
14
HHSearch
74.60
19%
-57
- C2 -
3UKN
-
?
A:
[556-740]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
D
L
K
D
F
I
R
V
H
R
L
P
K
A
L
A
Q
R
M
L
E
C
F
Q
T
T
W
S
V
N
N
G
--
I
D
V
S
E
L
L
K
D
F
P
D
E
L
R
A
------
D
I
A
M
H
L
N
K
E
-
L
L
Q
L
P
L
F
E
S
A
S
R
G
C
L
R
S
L
S
L
I
I
K
T
S
F
C
A
P
G
E
F
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Q
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D
A
L
Q
A
I
Y
F
V
C
S
G
S
M
E
V
L
K
D
N
-----------------
T
V
L
A
I
L
G
K
G
D
L
I
G
S
D
S
L
T
K
-
E
-
Q
V
I
K
-
T
N
A
N
V
K
A
L
T
Y
C
D
L
Q
Y
I
S
L
K
G
L
R
E
V
L
R
L
Y
-
P
E
Y
A
Q
K
F
V
S
E
I
Q
H
D
L
T
Y
-----------------------------------------------------------------------------------------------------------------------------
23
HHSearch
73.39
18%
-56
- C2 -
2Z69
-
?
A:
[7-138]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
Q
L
L
Q
S
H
H
L
F
E
P
L
S
P
V
Q
L
Q
E
L
L
A
S
S
D
L
V
N
L
D
K
G
A
Y
V
F
R
Q
G
E
P
A
H
A
F
Y
Y
L
I
S
G
C
V
K
I
Y
R
L
T
P
-----------------
I
L
E
V
T
N
E
R
N
T
F
A
E
A
M
M
F
M
-
D
-
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--
P
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V
A
T
A
Q
A
V
V
P
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Q
L
F
R
F
S
N
K
A
Y
L
R
Q
L
Q
D
N
-
T
P
L
A
L
A
L
L
A
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Q
R
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L
-------------------------------------------------------------------------------------------------------------------
24
HHSearch
72.82
17%
-43
- C2 -
2OZ6
2
VFR_PSEAE
A:
[4-146]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
L
D
K
L
L
A
H
C
H
R
R
R
Y
T
A
K
S
T
I
I
Y
A
G
D
R
C
E
T
L
F
F
I
I
K
G
S
V
T
I
L
I
E
D
D
-
D
G
-----------
R
E
M
I
I
G
Y
L
N
S
G
D
F
F
G
E
L
G
L
F
E
----Q-
E
-
R
S
A
W
V
R
A
K
V
E
C
E
V
A
E
I
S
Y
A
K
F
R
E
L
S
Q
Q
D
-
S
E
I
L
Y
T
L
G
S
Q
M
A
D
R
L
-
R
K
T
T
R
K
V
G
D
L
A
F
L
D
V
T
G
R
V
A
R
T
L
L
-
D
L
C
Q
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
-
T
-
R
Q
E
I
G
R
I
V
G
C
S
R
E
M
V
G
R
V
L
K
S
L
E
E
Q
G
L
V
H
V
K
G
K
T
M
V
V
F
G
T
---------------------------------------
25
HHSearch
72.14
16%
-42
- C2 -
3KCC
3
CRP_ECOLI
A:
[59-177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
-
G
-----------
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
E
G
-
Q
--
E
-
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
-
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
L
V
T
G
-
R
I
A
Q
T
L
L
-
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
-
T
-
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
-----------------------------------------
17
HHSearch
72.05
15%
-40
- C2 -
3GYD
2
?
A:
[37-173]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
I
V
N
K
I
K
L
F
G
D
F
S
N
E
E
V
R
Y
L
C
S
Y
M
Q
C
Y
A
A
P
R
D
C
Q
L
L
T
E
G
D
P
G
D
Y
L
L
L
I
L
T
G
E
V
N
V
I
K
D
I
P
N
-
K
-----------
G
I
Q
T
I
A
K
V
G
A
G
A
I
I
G
E
M
S
M
I
D
-
G
-
M
--
P
-
R
S
A
S
C
V
A
S
L
P
T
D
F
A
V
L
S
R
D
A
L
Y
Q
L
L
A
N
M
-
P
K
L
G
N
K
V
L
I
R
L
L
Q
L
L
T
A
R
F
R
E
S
Y
D
R
I
L
P
K
T
L
G
-
E
L
I
----------------------------------------------------------------------------------------------------------
12
HHSearch
66.41
18%
-57
- C2 -
3DKW
-
?
A:
[7-138]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
Q
L
L
Q
S
H
H
L
F
E
P
L
S
P
V
Q
L
Q
E
L
L
A
S
S
D
L
V
N
L
D
K
G
A
Y
V
F
R
Q
G
E
P
A
H
A
F
Y
Y
L
I
S
G
C
V
K
I
Y
R
L
T
P
E
-
G
-----------
Q
E
K
I
L
E
V
T
N
E
R
N
T
F
A
E
A
M
M
F
M
-
D
-
T
--
P
N
Y
V
A
T
A
Q
A
V
V
P
S
Q
L
F
R
F
S
N
K
A
Y
L
R
Q
L
Q
D
N
-
T
P
L
A
L
A
L
L
A
K
L
S
T
R
L
H
Q
R
I
D
E
I
E
T
L
S
L
K
N
A
T
H
-
R
V
V
R
Y
L
L
-
T
L
A
A
H
A
P
G
E
N
C
R
V
E
I
P
V
A
K
-
Q
-
L
V
A
G
H
L
S
I
Q
P
E
T
F
S
R
I
M
H
R
L
G
D
E
G
I
I
H
L
D
G
R
E
I
S
I
L
D
R
E
R
L
E
C
F
E
----------------------------------
21
HHSearch
65.37
17%
-18
- C2 -
3IWZ
-
CLP_XANCP
A:
[22-125]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L
D
A
G
T
I
E
R
F
L
A
H
S
H
R
R
R
Y
P
T
R
T
D
V
F
R
P
G
D
P
A
G
T
L
Y
Y
V
I
S
G
S
V
S
I
I
A
E
E
D
D
-
D
-----------
R
E
L
V
L
G
Y
F
G
S
G
E
F
V
G
E
M
G
L
F
I
-
E
S
D
--
T
-
R
E
V
I
L
R
T
R
T
Q
C
E
L
A
E
I
S
Y
E
R
L
Q
Q
L
F
Q
T
S
L
S
P
D
A
P
R
I
L
Y
A
I
G
V
Q
L
S
K
R
L
L
D
T
T
R
K
A
S
R
L
A
F
L
-
D
V
T
D
R
I
V
-
R
T
L
H
D
L
S
K
E
P
E
A
M
S
H
P
Q
G
T
-
Q
-
L
R
V
S
R
Q
E
L
A
R
L
V
G
C
S
R
E
M
A
G
R
V
L
K
K
L
Q
A
D
G
L
L
H
A
R
G
K
T
V
V
L
Y
G
------------------------------------
16
HHSearch
64.93
13%
-52
- C2 -
3OF1
2
KAPR_YEAST
A:
[5-182]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
S
I
R
N
N
F
L
F
N
K
L
D
S
D
S
K
R
L
V
I
N
C
L
E
E
K
S
V
P
K
G
A
T
I
I
K
Q
G
D
Q
G
D
Y
F
Y
V
V
E
K
G
T
V
D
F
Y
V
N
D
N
-----------------
K
V
N
S
S
G
P
G
S
S
F
G
E
L
A
L
M
Y
-
N
-
S
--
P
-
R
A
A
T
V
V
A
T
S
D
C
L
L
W
A
L
D
R
L
T
F
R
K
I
L
L
G
S
-
S
F
K
K
R
L
M
--------
Y
D
D
L
L
K
S
M
P
V
L
K
S
L
T
T
Y
-
D
R
A
K
L
A
D
A
L
D
T
K
I
Y
Q
P
G
E
T
I
I
R
E
G
D
Q
G
-
E
N
F
Y
L
I
E
Y
G
A
V
D
V
S
K
K
G
Q
G
V
I
N
K
L
K
D
H
D
Y
F
G
E
V
A
L
L
N
D
L
P
R
Q
A
T
V
T
A
T
K
R
T
K
V
A
T
L
G
K
S
G
F
Q
R
L
L
G
P
A
V
D
V
L
K
L
N
D
P
T
R
H
-
26
HHSearch
61.42
10%
-58
- C- -
3IDB
-
KAP3_RAT
B:
[34-158]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
L
Q
E
A
C
K
D
I
L
L
F
K
N
L
D
P
E
Q
M
S
Q
V
L
D
A
M
F
E
K
L
V
K
E
G
E
H
V
I
D
Q
G
D
D
G
D
N
F
Y
V
I
D
R
G
T
F
D
I
Y
V
K
C
D
--
G
-----------
V
G
R
C
V
G
N
Y
D
N
R
G
S
F
G
E
L
A
L
M
Y
-
N
-
T
--
P
-
R
A
A
T
I
T
A
T
S
P
G
A
L
W
G
L
D
R
V
T
F
R
R
I
I
V
K
N
-
N
A
K
K
R
K
M
Y
--------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
60.06
13%
-57
- C2 -
3E97
-
?
A:
[5-135]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
L
K
R
S
P
L
F
Q
N
V
P
E
D
A
M
R
E
A
L
K
V
V
T
E
R
N
F
Q
P
D
E
L
V
V
E
Q
D
A
E
G
E
A
L
H
L
V
T
T
G
V
V
R
V
S
R
V
S
L
--------------
R
E
R
V
L
G
D
I
Y
A
P
G
V
V
G
E
T
A
V
L
A
-
H
-
Q
--
E
-
R
S
A
S
V
R
A
L
T
P
V
R
T
L
M
L
H
R
E
H
F
E
L
I
L
R
R
H
-
P
R
V
L
W
N
L
A
E
M
L
A
R
R
V
T
F
L
N
D
E
L
I
A
F
G
Q
N
T
E
A
A
-
L
T
H
V
F
A
N
-
L
Y
R
Q
R
L
A
A
G
V
P
Q
P
E
V
L
P
L
G
-
T
-
Q
D
I
M
A
R
T
S
S
S
R
E
T
V
S
R
V
L
K
R
L
E
A
H
N
I
L
E
V
S
P
R
S
V
T
L
L
D
L
A
A
L
E
A
L
S
---------------------------------
9
HHSearch
60.03
13%
-99
- C2 -
1ZCD
-
NHAA_ECOLI
A:
[59-351]
---------------------------------------------------------------------------------------
M
L
L
W
I
N
D
A
L
M
A
V
F
F
L
L
V
G
L
E
V
K
R
E
L
M
Q
G
S
L
ASL
R
Q
A
A
F
P
V
I
A
A
I
G
G
M
I
V
P
A
L
L
Y
L
A
F
N
Y
-----
A
-
D
P
I
T
R
E
G
W
A
I
-
P
A
A
T
D
I
A
F
A
L
G
V
L
A
L
L
G
S
RV
P
L
A
L
K
I
F
L
M
A
L
A
I
I
D
D
L
G
A
I
I
I
I
A
L
F
Y
T
N
D
L
-----
S
M
A
----
S
L
G
-----
V
A
A
V
A
I
A
V
L
A
V
L
N
L
C
-
G
-
A
-
R
R
T
G
V
Y
----
I
L
V
G
V
V
L
W
T
A
V
L
K
S
G
V
H
A
T
L
A
G
V
I
V
G
F
F
I
P
L
K
E
K
H
G
R
S
P
A
K
R
L
E
H
V
L
H
P
W
V
A
Y
L
I
L
P
L
F
A
F
A
N
A
G
V
S
L
Q
G
V
T
L
D
G
---
L
T
S
I
L
P
L
G
I
I
A
G
L
L
I
G
K
P
L
G
I
S
L
F
C
W
L
A
L
R
L
KLAHL
P
E
G
T
T
Y
Q
Q
I
M
V
V
G
I
L
C
G
I
G
F
T
M
S
I
F
I
A
S
L
A
F
G
S
V
D
P
E
L
I
N
W
A
K
L
G
I
L
V
G
S
I
S
S
A
V
I
G
Y
S
W
L
R
V
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
57.54
12%
-53
- C2 -
3TNP
-
KAP3_MOUSE
B:
[143-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
A
C
K
D
I
L
L
F
K
N
L
D
P
E
Q
M
S
Q
V
L
D
A
M
F
E
K
L
V
K
E
G
E
H
V
I
D
Q
G
D
D
G
D
N
F
Y
V
I
D
R
G
T
F
D
I
Y
V
K
C
D
--
G
-----------
V
G
R
C
V
G
N
Y
D
N
R
G
S
F
G
E
L
A
L
M
Y
-
N
-
T
--
P
-
K
A
A
T
I
T
A
T
S
P
G
A
L
W
G
L
D
R
V
T
F
R
R
I
I
V
K
N
-
N
A
K
K
R
K
M
Y
E
S
--------
F
I
E
S
L
P
F
L
K
S
L
E
V
S
-
E
R
L
K
V
V
D
V
I
G
T
K
V
Y
N
D
G
E
Q
I
I
A
Q
G
D
L
A
D
S
-
F
F
I
V
E
S
G
E
V
K
I
T
M
K
V
E
I
A
R
C
F
R
G
Q
Y
F
G
E
L
A
L
V
T
N
K
P
R
A
A
S
A
H
A
I
G
T
V
K
C
L
A
M
D
V
Q
A
F
E
R
L
L
G
P
C
M
E
I
M
K
R
N
--------
33
Fugue
56.75
20%
85
- C2 -
2JMH
-
ALL5_BLOTA
A:
[1-117]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
H
K
P
----
K
K
D
-----
D
F
R
N
E
F
D
H
L
L
I
E
Q
A
N
H
A
I
E
K
G
E
H
Q
L
L
Y
L
Q
H
Q
L
D
E
L
N
E
N
KS
K
E
L
Q
E
K
I
I
R
E
L
D
V
V
C
A
M
I
E
G
A
Q
G
A
L
E
R
E
L
K
R
-
T
D
L
N
I
L
E
R
F
N
Y
E
E
A
Q
T
L
S
K
I
L
L
K
D
L
K
E
T
E
Q
K
V
K
D
I
Q
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
56.48
15%
-60
- C2 -
3RVY
5
?
A:
[19-205]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
L
R
I
T
N
I
V
E
S
S
F
F
T
K
F
I
I
Y
L
I
V
L
N
G
I
T
M
G
L
E
T
S
K
T
F
M
Q
S
F
G
V
Y
T
T
L
F
N
Q
I
V
I
T
I
F
T
I
E
I
I
L
R
I
Y
V
H
R
I
S
F
F
K
D
P
W
S
L
F
D
F
F
V
V
A
I
S
L
V
P
T
S
S
G
---------
F
E
I
L
R
V
L
R
V
L
R
L
F
R
L
V
T
A
V
P
Q
M
R
K
I
V
S
A
L
I
S
V
I
P
G
M
L
S
V
I
A
--
L
M
T
L
F
F
Y
I
F
A
I
M
A
T
Q
L
F
G
E
RFPEW
F
G
T
L
G
E
S
F
Y
T
L
F
Q
V
M
T
L
E
S
W
S
M
G
I
V
R
P
L
M
E
V
Y
P
Y
A
W
V
F
--
F
I
P
F
I
F
V
V
T
F
V
M
I
N
L
V
V
A
I
C
V
D
A
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
56.38
11%
-65
- C2 -
3J4Q
-
KAP2_MOUSE
B:
[128-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
A
C
K
D
I
L
L
F
K
N
L
D
Q
E
Q
L
S
Q
V
L
D
A
M
F
E
K
I
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K
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H
V
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D
D
G
D
N
F
Y
V
I
E
R
G
T
Y
D
I
L
V
T
K
D
--
N
-----------
Q
T
R
S
V
G
Q
Y
D
N
R
G
S
F
G
E
L
A
L
M
Y
-
N
-
T
--
P
-
R
A
A
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I
I
A
T
S
E
G
S
L
W
G
L
D
R
V
T
F
R
R
I
I
V
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N
-
N
A
K
K
R
K
M
F
--------
E
S
F
I
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V
P
L
F
K
S
L
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M
S
-
E
R
M
K
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-
F
Y
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S
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L
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