@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO1A2_HUMAN: (2015-12-12 )
MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETKVKGKENECKDIYQKSTVLKDDELKTKL
Atome Classification :
(20 SA)
---.........10........20........30........40......-.-.50.........60........70........80........90..---......100-.........110.......120.......130.......140.......150.....--..160--........170--.........180.......190.......200.....-..210.......220.......230..--..-.-..240---........250.......260.......270.-......280.......290.......300......-.310........320.......330.......340....-.---..350.......360.......370.......380.......390.......400.......410.......420....--...430.......440-.......450.......460.......-------470.......480.......490..--------.....500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MG
E
T
E
K
R
I
E
T
H
R
I
R
C
L
S
K
L
K
M
F
L
L
A
I
T
C
A
F
V
S
K
TL
S
G
S
Y
M
N
S
M
L
T
Q
I
-
E
-
R
Q
-FNI
P
T
S
L
V
G
F
INGSF
E
I
G
N
L
L
L
I
I
F
V
S
Y
F
G
TKLHR
P
I
M
I
G
I
G
C
---
V
V
M
G
L
G
C
---
F
L
K
S
L
P
H
F
L
M
N
Q
Y
EYE
S
T
V
S
V
SGNLSS
N
S
F
L
C
MENG
T
Q
I
LRPTQ
D
P
S
E
C
T
K
E
V
K
S
L
M
--
W
V
Y
V
---
L
V
G
N
I
V
R
GM----GETP
I
L
P
L
G
I
S
Y
I
E
D
F
A
K
FENS
P
L
Y
I
G
L
VET
G
A
I
I
G
P
-
L
I
G
L
L
L
A
S
F
C
AN
V
Y
V
DTGFVNTD
D
L
I
I
--TP-T-DT
R
W
----
V
G
A
W
W
F
G
F
L
I
C
A
G
V
N
V
L
T
A
I
P
F
F
FLPNTLPKE-GLETNA
D
I
IKNEN
E
D
K
Q
K
E
E
V
K
K
E
KYGI
T
K
D
F
L
P
F
-
M
K
S-LSC
N
P
I
Y
M
L
F
I
L
V
S
V
I
Q
F
N
A
F
V
N
M
I
S
F
M
P
K
Y
L
E
Q
Q-Y---GISSS
D
A
I
F
L
M
GIYNL
P
P
I
C
I
G
Y
I
I
G
G
L
I
M
K
K
F
K
I
T
V
K
QAA
H
I
G
C
W
L
S
L
L
E
Y
L
L
Y
F
L
S
F
L
M
TCENS
S
V
V
G
INTSYEGIP--QDLYVENDIFADCNVD-CNC
P
S
K
IWDPVCGNN
G
L
S
Y
L
S
A
C
L
A
GC-------ETSIG
T
G
I
N
M
V
FQNC
S
C
I
QTSGNS
S
--------
A
V
L
G
LCDKGP
D
C
S
L
M
L
Q
Y
F
L
I
L
S
A
M
S
S
F
I
Y
S
L
A
A
I
P
G
Y
M
V
L
L
R
C
M
KSE
E
K
SL
G
V
G
L
H
T
F
C
T
R
V
FAGI
P
A
P
I
Y
F
G
A
LMDSTCL
H
W
G
TLKCGESG
A
C
R
I
YDST
T
F
R
Y
I
Y
LGL
P
A
ALRGS
S
F
V
P
A
L
I
I
L
I
L
L
R
K
CHLPGENASSG
T
E
L
I
E
T
KVKGKE
N
E
C
K
D
I
Y
Q
K
STVLKD
D
E
LKTKL-
34
Fugue
78.26
12%
-88
- C1 -
1KPK
-
CLCA_ECOLI
A:
[12-461]
Q
A
A
R
L
R
R
R
Q
L
I
R
Q
L
L
E
R
D
K
T
P
L
A
I
L
F
M
A
A
V
V
G
T
L
V
G
L
A
A
V
A
F
D
K
G
V
A
W
L
Q
-
N
-
Q
R
-
M
G
A
L
V
H
T
A
D
N
Y
P
L
L
L
T
V
A
F
L
C
S
A
V
L
A
M
F
G
Y
F
L
V
R
K
Y
A
P
E
A
G
G
S
---
G
I
P
E
I
E
G
---
A
L
E
D
Q
R
P
V
R
-------------------------------------
W
W
R
V
L
P
V
K
F
F
G
--
G
L
G
T
---
L
G
G
G
M
V
L
G
-----
R
E
G
P
T
V
Q
I
G
G
N
I
G
R
M
V
L
D
I
F
R
L
K
-------
G
D
E
A
R
H
T
-
L
L
A
T
G
A
A
A
G
L
A
A
A
F
----------------------------------
N
A
P
L
A
G
I
L
F
I
I
E
E
M
R
P
Q
F
R
Y
T
L
I
S
I
K
-
A
V
F
I
G
V
I
M
S
T
I
M
Y
R
I
F
N
H
---
E
V
A
L
I
D
V
G
K
L
S
D
A
----
P
-
L
N
T
L
W
L
Y
L
I
L
G
I
I
F
G
I
F
G
P
I
F
N
K
W
V
L
G
M
Q
D
L
L
H
R
V
-
H
---
G
-----------------------------
G
N
I
T
K
W
V
L
M
G
G
A
I
G
G
L
C
G
L
L
G
F
V
A
------------------------------------------------------------------------------
P
A
T
S
G
G
G
F
N
-----------------------------------------------------
L
I
P
I
A
T
A
G
N
F
S
M
G
M
L
V
F
I
F
V
A
R
V
I
T
T
L
L
C
F
S
S
G
A
P
G
G
I
F
A
P
M
L
A
L
G
T
V
L
G
T
A
F
G
M
V
A
V
E
L
F
P
Q
Y
-----
H
L
E
A
G
T
F
A
I
A
G
M
G
A
L
L
A
A
S
I
R
A
P
L
T
G
I
I
L
V
L
E
M
T
D
N
Y
Q
L
I
L
P
M
I
I
T
G
L
G
A
T
L
L
A
Q
F
T
G
G
K
P
L
Y
S
A
I
L
A
R
T
L
A
K
Q
E
A
E
Q
L
39
HHSearch
70.67
15%
-99
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[30-324]
---------------------------
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
-
Q
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
---
F
L
Y
A
L
G
A
---
A
L
F
W
P
A
A
E
----------------------------------------------
I
M
N
--
Y
T
L
F
---
L
V
G
L
F
I
I
A
A
----
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
-
V
L
D
K
M
--
S
P
E
Q
-
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
-
K
F
P
A
L
--
Q
S
D
N
H
-
S
D
A
------------------
K
Q
G
S
F
S
A
S
-
L
S
R
-
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
-
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
--
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
-
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
-------
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
67.54
10%
-86
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-----------------------------------------------
F
K
P
-
A
-
P
H
-
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
---
Y
L
V
E
Q
G
F
---
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
V
P
W
A
T
S
S
I
A
V
M
---
F
V
L
L
F
L
C
G
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
-----------------------------
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
--------------------
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
-
P
G
T
L
L
C
G
W
M
S
D
K
V
F
----
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
--
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
-
L
-----------
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
-------
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
--------
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
64.38
13%
-90
- C3 -
2GFP
-
EMRD_ECOLI
A:
[21-270]
------------------------------------
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
-
A
-
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
M
---
S
I
F
M
L
A
T
---
L
V
A
V
T
T
S
-------------------------------------------------
S
--
L
T
V
L
---
I
A
A
S
A
M
Q
G
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
------------------------------
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
-
D
A
P
-
R
------------------------
T
R
L
L
T
S
-
Y
K
T
-
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
-
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
--
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
-
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
-------
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
55.85
16%
-93
- C3 -
2CFQ
-
LACY_ECOLI
A:
[20-288]
------------------------------------
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
-
L
-
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
---
F
I
F
I
F
G
P
------------------------------------------------
L
L
--
Q
Y
N
I
---
L
V
G
S
I
V
G
G
I
YLGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
I
-------------------------------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
-
A
T
V
A
N
-
A
V
----------------
G
A
N
H
S
A
F
S
L
K
L
-
A
L
E
-
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
-
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
--
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
-
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
-------
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
--------
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
55.43
12%
-102
- C3 -
1PW4
-
GLPT_ECOLI
A:
[34-318]
----------------------------
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
--
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
---
I
L
A
A
A
V
M
---
L
F
M
G
F
V
P
W
A
---------------------------------------------
T
S
S
--
I
A
V
M
---
F
V
L
L
F
L
C
G
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
-----------------------------
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
-
C
G
L
P
P
I
E
E
Y
K
N
D
------------------
T
A
K
Q
I
F
M
Q
Y
-
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
-
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
--
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
-
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
-------
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
--------
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
47.50
15%
-119
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[36-178]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
--
F
---
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
-
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
--
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
---
P
A
A
------------------------------------------------------------------------------------------------------------------
E
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
-
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
-
38
HHSearch
47.17
15%
-99
* C3 *
3WDO
-
?
A:
[21-181]
----------------------------------
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
-
A
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
---
A
V
F
A
A
G
S
---
V
I
A
A
L
S
D
-------------------------------------------------
S
--
I
W
G
I
---
I
L
G
R
A
L
Q
G
S
----
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
------------------------------
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
-
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
-
L
M
S
-
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
-
P
---
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
--
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
-
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
-------
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
--------
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
---------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
44.61
13%
-98
- C3 -
1PW4
-
GLPT_ECOLI
A:
[274-430]
--------------------------------------------
D
W
S
P
T
Y
-
L
K
E
V
-
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
---
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
----------------------------------------------
G
N
P
---
T
V
D
---
M
I
C
M
I
V
I
G
F
----
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
------------------------------
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
-
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
44.07
12%
-127
- C3 -
3WDO
-
?
A:
[12-160]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
---
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
-
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
--
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
A
A
---
L
S
---------------------------------------------------------------------------------------------------------------------
D
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
--
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
-
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
-
19
PsiBlast_PDB
41.66
24%
-16
- C1 -
3DY5
-
AOSL_PLEHO
A:
[504-650]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
K
E
L
E
Q
R
K
L
T
Y
Q
--
W
D
Y
V
SDD
M
P
G
N
I
K
A
K
T
----
H
D
D
--
L
P
R
D
V
Q
F
T
D
E
K
S
R
S
Y
Q
E
S
R
K
A
A
L
V
N
L
G
-------
I
G
S
L
--------------------------------
W
----
H
E
D
R
W
F
G
Y
Q
F
L
N
G
A
N
P
V
I
L
T
R
C
D
A
L
P
S
N
F
P
V
T
-
N
E
H
V
N
A
S
L
D
R
G
K
N
L
D
---
E
E
I
K
D
G
H
I
Y
I
V
D
F
K
V
L
V
-
G
A
K
-
S
Y
G
G
P
V
L
E
D
I
G
E
A
D
I
R
Y
C
A
A
P
L
A
L
F
Y
V
N
K
L
G
H
L
M
P
-
I
---
A
I
Q
I
N
Q
E
P
G
P
E
N
P
I
W
T
P
H
E
E
N
E
H
D
W
M
M
A
K
F
W
L
G
V
A
E
S
N
F
H
Q
L
N
T
H
L
L
R
T
H
L
T
T
E
S
F
A
L
S
T
W
R
N
L
A
S
A
H
P
I
F
K
L
L
Q
P
H
I
Y
--
G
V
L
A
I
D
T
I
G
R
K
E
L
I
G
S
-
G
G
I
V
D
Q
S
L
S
L
G
G
G
G
H
V
T
F
M
E
K
C
F
K
E
V
N
-------
L
Q
D
Y
H
L
P
N
A
L
K
K
R
G
V
D
D
P
S
K
L
P
G
F
Y
--------
Y
R
D
D
G
L
A
L
W
E
A
I
E
T
F
I
G
E
I
I
A
I
F
Y
K
N
D
D
D
V
K
R
D
N
E
I
Q
S
W
I
Y
D
V
H
K
N
G
W
R
V
N
P
G
H
Q
D
H
G
V
P
A
S
F
E
S
R
E
Q
L
K
E
V
L
T
S
L
V
F
T
F
S
C
Q
H
A
A
V
N
F
S
Q
K
N
A
P
A
I
L
R
H
P
P
P
K
K
K
G
E
A
T
L
Q
S
I
L
S
T
L
P
S
K
S
Q
A
A
K
A
I
A
T
V
Y
I
L
T
K
F
S
E
D
E
R
Y
L
G
N
Y
S
A
T
A
W
E
D
K
D
A
L
D
A
I
N
R
F
Q
D
K
L
E
D
I
S
K
K
I
K
-
46
HHSearch
40.96
14%
-120
- C3 -
2GFP
-
EMRD_ECOLI
A:
[24-158]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
--
L
---
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
-
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
--
R
P
V
I
L
V
G
M
S
I
F
M
L
A
T
L
V
A
V
---
T
T
---------------------------------------------------------------------------------------------------------------------
S
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
-
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
-
12
PsiBlast_PDB
39.88
21%
-16
- C1 -
4DQ6
2
?
A:
[209-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
L
K
K
H
K
H
I
P
M
A
S
I
S
K
E
F
E
K
N
T
I
T
C
M
A
P
T
K
T
F
N
I
A
G
L
Q
S
S
Y
V
V
L
P
D
E
K
D
Y
K
L
L
D
D
A
F
T
R
I
D
I
K
R
N
N
C
F
S
L
V
A
T
E
A
S
Y
N
N
G
E
S
W
L
E
S
F
L
E
Y
L
-------
E
S
N
I
D
F
A
I
K
Y
I
N
E
N
M
P
K
L
K
V
R
K
P
E
G
TY
L
L
W
V
D
F
S
A
L
G
L
S
D
E
E
L
E
S
I
L
V
Q
K
G
K
V
A
L
N
Q
G
N
S
F
G
I
G
G
S
G
Y
Q
R
I
N
L
A
C
P
R
S
M
L
E
E
A
L
I
R
I
K
N
A
I
N
----------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
39.24
21%
-27
- C1 -
4DGT
2
?
A:
[209-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
L
K
K
H
K
H
I
P
M
A
S
I
S
K
E
F
E
K
N
T
I
T
C
M
A
P
T
K
T
F
N
I
A
G
L
Q
S
S
Y
V
V
L
P
D
E
K
D
Y
K
L
L
D
D
A
F
T
R
I
D
I
K
R
N
N
C
F
S
L
V
A
T
E
A
S
Y
N
N
G
E
S
W
L
E
S
F
L
E
Y
L
-------
E
S
N
I
D
F
A
I
K
Y
I
N
E
N
M
P
K
L
K
V
R
K
P
E
G
TY
L
L
W
V
D
F
S
A
L
G
L
S
D
E
E
L
E
S
I
L
V
Q
K
G
K
V
A
L
N
Q
G
N
S
F
G
I
G
G
S
G
Y
Q
R
I
N
L
A
C
P
R
S
M
L
E
E
A
L
I
R
I
K
N
A
I
N
----------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
38.70
45%
112
- C2 -
2KMQ
-
LDTI_HIRME
A:
[4-44]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
P
-
K
I
L
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
P
T
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
37.68
45%
113
- C2 -
1LDT
-
LDTI_HIRME
L:
[4-44]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
P
-
K
I
L
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
I
A
R
C
NGVSIKS
E
G
S
C
P
T
G
I
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
37.42
10%
52
- C1 -
3VIQ
-
SWI5_SCHPO
B:
[1-85]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
S
-
Q
L
E
S
R
V
H
L
L
E
Q
Q
K
E
Q
L
E
S
S
L
Q
D
A
L
A
K
L
K
N
R
D
A
K
Q
T
-
V
Q
K
H
I
D
L
L
H
T
Y
N
E
I
R
D
I
A
L
G
M
I
G
K
V
A
E
H
E
K
C
T
S
V
E
L
F
D
R
-
F
---
G
V
N
G
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
37.21
24%
-4
- C1 -
3FG4
23
AOSL_PLEHO
A:
[134-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
K
E
L
E
Q
R
K
L
T
Y
Q
--
W
D
Y
V
SDD
M
P
G
N
I
K
A
K
T
----
H
D
D
--
L
P
R
D
V
Q
F
T
D
E
K
S
R
S
Y
Q
E
S
R
K
A
A
L
V
N
L
G
-------
I
G
S
L
F
T
M
F
E
N
W
D
S
Y
D
D
Y
H
I
L
Y
R
N
W
I
L
GG
T
P
-
N
M
A
D
R
W
----
H
E
D
R
W
F
G
Y
Q
F
L
N
G
A
N
P
V
I
L
T
R
C
D
A
L
P
S
N
F
P
V
T
-
N
E
H
V
N
A
S
L
D
R
G
K
N
L
D
---
E
E
I
K
D
G
H
I
Y
I
V
D
F
K
V
L
V
-
G
A
K
-
S
Y
G
G
P
V
L
E
D
I
G
Y
K
V
P
D
E
A
D
I
R
Y
C
A
A
P
L
A
L
F
Y
V
N
K
L
-
G
---
H
L
M
P
I
A
I
Q
I
N
Q
E
P
G
P
E
N
P
I
W
T
P
H
E
E
N
E
H
D
W
M
M
A
K
F
W
L
G
V
A
E
S
N
F
H
Q
L
N
T
H
L
L
R
T
H
L
T
T
E
S
F
A
L
S
T
W
R
N
L
A
S
A
H
P
I
F
K
L
L
--
Q
P
H
I
Y
G
V
L
A
I
D
T
I
G
R
K
-
E
G
G
I
V
D
Q
S
L
S
L
G
G
G
G
H
V
T
F
M
E
K
C
F
K
E
V
-------
N
L
Q
D
Y
H
L
P
N
A
L
K
K
R
G
V
D
D
P
S
K
L
P
G
F
--------
Y
Y
R
D
D
G
L
A
L
W
E
A
I
E
T
F
I
G
E
I
I
A
I
F
Y
K
N
D
D
D
V
K
R
D
N
E
I
Q
S
W
I
Y
D
V
H
K
N
G
W
R
V
N
P
G
H
Q
D
H
G
V
P
A
S
F
E
S
R
E
Q
L
K
E
V
L
T
S
L
V
F
T
F
S
C
Q
H
A
A
V
N
F
S
Q
K
D
H
Y
G
F
T
P
N
A
P
A
I
L
R
H
P
P
P
K
K
K
G
E
A
T
L
Q
S
I
L
S
T
L
P
S
K
S
Q
A
A
K
A
I
A
T
V
Y
I
L
T
K
F
S
E
D
E
R
Y
L
G
N
Y
S
A
T
A
W
E
D
K
D
A
L
D
A
I
N
R
F
Q
D
K
L
-
13
PsiBlast_PDB
37.19
24%
-8
- C1 -
3FG1
26
AOSL_PLEHO
A:
[134-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
K
E
L
E
Q
R
K
L
T
Y
Q
--
W
D
Y
V
SDD
M
P
G
N
I
K
A
K
T
----
H
D
D
--
L
P
R
D
V
Q
F
T
D
E
K
S
R
S
Y
Q
E
S
R
K
A
A
L
V
N
L
G
-------
I
G
S
L
F
T
M
F
E
N
W
D
S
Y
D
D
Y
H
I
L
Y
R
N
W
I
L
GG
T
P
-
N
M
A
D
R
W
----
H
E
D
R
W
F
G
Y
Q
F
L
N
G
A
N
P
V
I
L
T
R
C
D
A
L
P
S
N
F
P
V
T
-
N
E
H
V
N
A
S
L
D
R
G
K
N
L
D
---
E
E
I
K
D
G
H
I
Y
I
V
D
F
K
V
L
V
-
G
A
K
-
S
Y
G
G
P
V
L
E
D
I
G
Y
K
E
A
D
I
R
Y
C
A
A
P
L
A
L
F
Y
V
N
K
L
G
H
L
-
M
---
P
I
A
I
Q
I
N
Q
E
P
G
P
E
N
P
I
W
T
P
H
E
E
N
E
H
D
W
M
M
A
K
F
W
L
G
V
A
E
S
N
F
H
Q
L
N
T
H
L
L
R
T
H
L
T
T
E
S
F
A
L
S
T
W
R
N
L
A
S
A
H
P
I
F
K
L
L
Q
P
H
--
I
Y
G
V
L
A
I
D
T
I
G
R
K
E
L
I
-
G
S
G
G
I
V
D
Q
S
L
S
L
G
G
G
G
H
V
T
F
M
E
K
C
F
K
E
-------
V
N
L
Q
D
Y
H
L
P
N
A
L
K
K
R
G
V
D
D
P
S
K
L
P
G
--------
F
Y
Y
R
D
D
G
L
A
L
W
E
A
I
E
T
F
I
G
E
I
I
A
I
F
Y
K
N
D
D
D
V
K
R
D
N
E
I
Q
S
W
I
Y
D
V
H
K
N
G
W
R
V
N
P
G
H
Q
D
H
G
V
P
A
S
F
E
S
R
E
Q
L
K
E
V
L
T
S
L
V
F
T
F
S
C
Q
H
A
A
V
N
F
S
Q
K
D
H
Y
G
F
T
P
N
A
P
A
I
L
R
H
P
P
P
K
K
K
G
E
A
T
L
Q
S
I
L
S
T
L
P
S
K
S
Q
A
A
K
A
I
A
T
V
Y
I
L
T
K
F
S
E
D
E
R
Y
L
G
N
Y
S
A
T
A
W
E
D
K
D
A
L
D
A
I
N
R
F
Q
D
K
-
16
PsiBlast_PDB
37.18
24%
-10
- C1 -
3FG3
8
AOSL_PLEHO
A:
[134-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
K
E
L
E
Q
R
K
L
T
Y
Q
--
W
D
Y
V
SDD
M
P
G
N
I
K
A
K
T
----
H
D
D
--
L
P
R
D
V
Q
F
T
D
E
K
S
R
S
Y
Q
E
S
R
K
A
A
L
V
N
L
G
-------
I
G
S
L
F
T
M
F
E
N
W
D
S
Y
D
D
Y
H
I
L
Y
R
N
W
I
L
GG
T
P
-
N
M
A
D
R
W
----
H
E
D
R
W
F
G
Y
Q
F
L
N
G
A
N
P
V
I
L
T
R
C
D
A
L
P
S
N
F
P
V
T
-
N
E
H
V
N
A
S
L
D
R
G
K
N
L
D
---
E
E
I
K
D
G
H
I
Y
I
V
D
F
K
V
L
V
-
G
A
K
-
S
Y
G
G
P
V
L
E
D
I
G
Y
K
V
P
D
E
A
D
I
R
Y
C
A
A
P
L
A
L
F
Y
V
N
K
L
-
G
---
H
L
M
P
I
A
I
Q
I
N
Q
E
P
G
P
E
N
P
I
W
T
P
H
E
E
N
E
H
D
W
M
M
A
K
F
W
L
G
V
A
E
S
N
F
H
Q
L
N
T
H
L
L
R
T
H
L
T
T
E
S
F
A
L
S
T
W
R
N
L
A
S
A
H
P
I
F
K
L
L
--
Q
P
H
I
Y
G
V
L
A
I
D
T
I
G
R
K
-
E
L
W
G
S
G
G
I
V
D
Q
S
L
S
L
G
G
G
G
H
V
T
F
M
E
K
C
-------
F
K
E
V
N
L
Q
D
Y
H
L
P
N
A
L
K
K
R
G
V
D
D
P
S
K
--------
L
P
G
F
Y
Y
R
D
D
G
L
A
L
W
E
A
I
E
T
F
I
G
E
I
I
A
I
F
Y
K
N
D
D
D
V
K
R
D
N
E
I
Q
S
W
I
Y
D
V
H
K
N
G
W
R
V
N
P
G
H
Q
D
H
G
V
P
A
S
F
E
S
R
E
Q
L
K
E
V
L
T
S
L
V
F
T
F
S
C
Q
H
A
A
V
N
F
S
Q
K
D
H
Y
G
F
T
P
N
A
P
A
I
L
R
H
P
P
P
K
K
K
G
E
A
T
L
Q
S
I
L
S
T
L
P
S
K
S
Q
A
A
K
A
I
A
T
V
Y
I
L
T
K
F
S
E
D
E
R
Y
L
G
N
Y
S
A
T
A
W
E
D
K
D
A
L
D
A
I
N
R
F
-