@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO1B1_HUMAN: (2015-12-12 )
MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50.....-.-.-.60--........70.---.......80-------.........90.-.......100-.......---..110.......120.......130.......140.......150......--.160.......170.......180----..----......190.......200.......210.......220........230.......240.......-.250..--..------...260.......270....-.-..280.......----------290.......300.......310----........320------.......-.330.......--340.......350..-------.....360....-.---..---370--------.........380.......390.......400.......410-----.........420.......430.......440.......-----450.......460-.---------------......470---.......480......-.490........500.-------......510.......520.......530----.......540.......550.......560......----.570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690---------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------MDQNQHLNKTAEAQPSENK
K
T
R
Y
C
N
G
L
K
M
F
L
A
A
L
S
L
S
F
I
A
K
T
L
G
A
I
I
M
KS
S
I
I
H
I
E
-
R
-
R
-FEI--
S
S
S
L
V
G
FIDGS---FEI
G
N
L
L
V
--------
I
V
F
V
S
Y
F
G
SKLH-R
P
K
L
I
G
I
G
---
C
F
I
M
G
I
G
---
G
V
L
T
A
L
P
H
F
F
M
G
Y
Y
RYSKETNINSSENS
T
S
T
L
S
T
C
L
I
N
Q
I
L
S
LNRA
S
P
E
I
V
--
G
K
G
C
LKESG
S
Y
M
W
I
Y
V
F
M
G
N
M
L
R
-----GI----GET
P
I
VP
L
G
L
S
Y
I
D
D
F
A
KEGH
S
S
L
Y
L
G
I
L
N
A
I
A
M
I
G
P
-
I
I
G
F
T
L
G
S
L
F
S
K
M
Y
V
D
I
G
Y
V
-
D
L
S
T
I
R
IT-PTDSR
W
--
V
G
------
A
W
W
L
N
F
L
V
S
G
L
F
S
I
I
S
SI
P
F
-
F
-FLPQTPNK
P
Q
K
E
----------RKAS
L
S
L
H
V
L
ETNDEKDQTANL-----TNQGK
N
I
T
K
N
-------
V
T
G
F
F
Q
S
-
F
K
S
I
LTN
P
L
Y
V
--
M
F
V
L
L
T
L
L
Q
V
S
S
Y
I
G
-------
A
F
T
Y
V
F
K
Y
V
E
Q
Q
-Y---GQ---P----------SSKA
N
I
L
L
G
V
I
T
I
P
I
FASG
M
F
L
G
G
Y
I
I
K
K
F
K
LNTVGI
A
K
F
-------
S
C
F
T
A
V
M
S
L
S
F
Y
L
L
Y
F
F
I
L
CENKSV
A
G
L
T
M
T
YDGNNPVT-----SHRDV
P
L
S
Y
CNSD-C---------------NCDESQWEP---VCGNNG
I
T
Y
I
S
P
C
L
AG-CKS-SSGNKK
P
I
V
F
Y
N-------C
S
C
L
E
V
TGLQNRNYSAHLGECPRDDAC
T
R
----
K
F
Y
F
F
V
A
I
Q
V
L
N
L
F
F
S
ALGGT
S
H
V
M
L
I
V
K
IV
Q
P
E
L
K
----
S
L
A
L
G
F
H
S
M
V
I
R
A
L
G
G
I
L
A
P
I
Y
F
G
A
LID
T
T
C
I
K
WSTNNCGTRGS
C
R
TYNST
S
F
S
R
V
Y
L
G
L
S
S
M
L
R
V
S
S
L
V
L
Y
I
I
L
I
Y
A
M
K
K
K
Y
QEKDINASENGSVM
D
E
A
N
L
E
S
LNKNKHFVPSAGADSETHC----------------------------------------
22
Fugue
77.99
18%
-86
* C3 *
4QFH
2
?
A:
[6-615]
------------------------------------------------------------------------------------------------------------------------------------------------H
H
H
M
K
D
Q
Y
L
K
D
L
T
V
H
L
N
E
S
-
N
A
A
P
A
N
T
S
M
A
V
A
S
F
N
M
P
H
E
I
T
R
R
M
R
P
L
G
V
D
A
D
T
S
L
T
S
C
P
S
W
R
R
L
Q
-
E
-
L
-
Y
E
I
HG
S
E
S
I
L
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
V
D
LRSSDK
N
F
V
F
L
D
Y
--
S
K
T
H
I
N
D
E
I
K
D
V
L
---
F
K
L
V
E
E
R
---
G
I
R
A
F
M
R
A
L
F
A
G
-------
E
K
V
N
T
A
E
N
R
S
-------
V
L
H
I
A
L
R
N
R
S
N
R
P
I
F
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
GEWK
G
Q
----
S
G
K
P
I
---------------
R
H
V
V
N
I
G
I
G
G
S
D
--
L
G
P
-
M
M
A
C
E
A
L
R
P
F
S
D
R
R
I
S
M
H
F
V
-
S
--------
N
I
D
G
T
H
--
L
S
------
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
-
T
-
T
Q
E
T
I
T
N
A
L
S
A
R
----------
N
E
F
L
K
F
L
S
S
R
G
I
S
E
A
G
A
V
A
K
H
F
-----
V
A
L
S
T
N
-
A
E
K
-------
V
K
E
F
G
I
D
-
E
E
N
M
F
Q
F
W
D
W
V
GG
R
Y
S
L
W
S
A
I
G
L
S
V
M
I
S
IG
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
-
F
---
I
N
---
A
----------
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
----------------------------
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
--
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
-----
N
G
R
M
V
S
-------------------------------------------
T
H
T
G
P
I
I
F
G
-
E
A
G
-
T
N
G
Q
H
A
F
Y
Q
L
I
H
QGT
K
L
I
P
C
D
F
I
G
A
I
Q
T
Q
N
Y
I
G
E
H
H
R
I
L
M
S
N
F
F
A
Q
T
E
----
A
L
M
I
G
K
T
P
E
E
V
K
R
E
L
E
S
A
G
G
K
S
E
D
E
I
Q
L
L
I
P
Q
K
T
F
T
GG
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
----------------
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
K
S
I
L
L
-------------
Q
L
Q
P
G
Q
K
V
T
N
H
D
S
S
T
N
G
L
I
E
L
F
N
E
R
S
H
-----------------------------------------------------
31
HHSearch
60.26
14%
-89
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[30-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
-
Q
-
A
-
F
T
L
--
T
N
F
Q
A
G
L
I
Q
S
A
---
F
Y
F
G
Y
F
I
I
--------
P
I
P
A
G
I
L
M
K
K
L
S
-
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
---
A
A
L
F
W
P
A
A
E
I
-----------------------------------------------------
M
N
Y
T
L
F
L
V
G
L
F
I
I
-----
A
A
----
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
------
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
-
M
-
L
T
-
K
F
P
A
L
Q
S
D
N
----------
H
S
D
A
--------------------------------
K
-------
Q
G
S
F
S
A
S
-
L
S
R
L
A
R
I
R
H
W
R
--
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
-------
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
---
T
----------
A
G
F
A
A
N
Y
L
T
G
T
M
V
-
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
-------
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
-----
G
I
K
N
L
G
Q
D
T
K
Y
G
S
-
S
---------------
F
I
V
M
T
I
I
G
G
---
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
-
I
P
T
-
A
E
L
I
P
A
L
C
F
A
V
I
-------
F
I
F
A
R
F
R
S
Q
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
51.91
14%
-77
- C2 -
2GFP
-
EMRD_ECOLI
A:
[19-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
-
R
-
D
-
L
N
V
--
R
E
G
A
V
Q
S
V
M
G
A
---
Y
L
L
T
Y
G
V
S
--------
Q
L
F
Y
G
P
I
S
D
R
V
G
-
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
---
T
L
V
A
V
T
T
S
S
--------------------------------------------------------
L
T
V
L
I
A
A
S
A
M
Q
-----
G
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
--------------------------------
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
-
A
R
W
M
P
E
T
R
P
V
D
A
P
------------
R
-------------------------------------------
T
R
L
L
T
S
-
Y
K
T
L
F
G
N
S
G
F
N
--
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
-------
F
E
A
C
S
G
V
L
M
G
A
V
-
L
---
G
L
---
S
----------
S
M
T
V
S
I
L
F
I
L
P
I
P
-
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
-------
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
-----
A
T
S
G
A
M
E
P
F
P
F
L
A
-
G
---------------
T
A
G
A
L
V
G
G
L
---
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
-
Q
T
G
-
Q
G
S
L
G
L
L
M
T
L
M
G
-------
L
L
I
V
L
C
W
L
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
51.36
9%
-59
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
------
V
-
E
-
Q
G
F
--
S
R
G
D
L
G
F
A
L
S
G
---
I
S
I
A
Y
G
F
S
--------
K
F
I
M
G
S
V
S
D
R
S
N
-
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
---
M
L
F
M
G
F
V
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
-------------
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
--------------
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
-----
Y
M
P
A
F
C
A
I
-
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
-
P
I
E
E
Y
K
N
D
-
T
A
K
Q
I
F
--
M
Q
YVLPN
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
-
D
-
W
S
P
T
Y
L
K
E
V
K
H
F
----------
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
-----
C
G
W
M
S
D
K
V
F
R
GN
R
G
A
T
G
V
F
F
M
T
L
V
-
T
I
A
T
I
V
Y
W
M
N
P
--
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
-------
F
L
I
Y
G
P
V
M
L
I
G
L
-
H
---
A
L
E
LA
P
----------
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
-------
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
46.51
17%
-105
- C2 -
3WDO
-
?
A:
[19-187]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
-
L
-
Q
G
A
--
S
E
A
L
I
G
I
A
I
G
I
---
Y
G
L
T
Q
A
V
F
--------
Q
I
P
F
G
L
L
S
D
R
I
G
-
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
---
S
V
I
A
A
L
S
D
S
--------------------------------------------------------
I
W
G
I
I
L
G
R
A
L
Q
-----
G
S
----
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
--------------------------------
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
-
V
V
P
N
S
S
T
H
V
L
N
R
----------
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
-----
F
G
I
M
C
L
H
M
L
L
-------
M
S
T
F
V
A
L
-
P
G
Q
L
A
D
A
G
F
P
A
--
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
-------
G
S
V
V
P
F
I
I
Y
A
E
V
-
K
---
R
K
---
M
----------
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
-------
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
-----
L
G
G
W
I
D
G
M
F
D
G
Q
G
-
V
---------------
F
L
A
G
A
M
L
A
A
---
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
-
S
L
R
-
I
E
I
P
A
D
I
A
A
N
E
A
-------
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
----
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
45.79
8%
-68
- C2 -
3IBV
-
XPOT_SCHPO
A:
[3-977]
M
S
A
Q
D
V
E
N
A
V
E
A
A
L
DPSVG
P
I
I
K
Q
Q
A
T
D
F
I
G
S
L
R
SSST
G
W
K
I
C
H
E
IFSEKTKYK
P
S
T
R
L
I
C
L
Q
T
L
S
E
K
V
R
E
WNNESN
L
L
E
L
Q
M
I
R
D
S
V
W
S
Y
I
K
E
L
S
F
L
D
E
P
A
Y
I
S
N
A
V
Q
H
L
L
T
L
L
F
L
Q
LYPSNWND
F
F
A
S
L
Q
G
V
I
A
A
S
SQ
S
E
F
S
N
F
Y
L
K
V
L
L
S
I
G
D
E
I
A
D
S
L
V
L
K
T
D
V
Q
I
Q
K
D
N
L
V
K
D
A
I
R
A
N
D
M
S
D
I
V
S
F
V
Y
E
M
M
L
A
Y
S
N
A
K
N
Y
G
T
V
G
-
L
-
C
-
L
Q
V
--
Y
A
Q
W
V
S
W
I
N
I
N
---
L
I
V
N
E
P
C
M
--------
N
L
L
Y
S
F
L
Q
I
E
E
L
-
R
C
A
A
C
E
T
M
---
T
E
I
V
N
K
K
---
M
K
P
L
E
K
L
N
L
L
N
I
L
N
L
N
L
F
F
S
K
--
T
D
P
N
F
D
E
H
V
A
K
L
I
N
A
Q
G
V
E
L
V
A
I
K
S
D
P
S
--
S
P
E
L
K
E
N
C
S
F
Q
L
Y
N
L
F
P
Y
L
I
R
Y
L
-----
S
D
----
D
Y
D
E
T
S
T
A
V
F
P
F
L
S
D
L
L
V
S
L
R
K
E
S
S
S
K
E
L
S
--
A
S
L
K
E
-
F
L
K
S
L
L
E
A
I
I
K
K
M
K
Y
D
E
S
Q
E
-
W
D
D
D
P
D
S
E
-
E
E
A
E
F
Q
--
E
M
------
R
K
K
L
K
I
F
Q
D
T
I
N
S
I
D
S
S
L
F
S
-
S
-
Y
M
Y
S
A
I
T
S
S
L
S
T
A
A
T
L
SPENS
W
Q
L
I
E
F
A
L
Y
E
T
Y
I
F
G
E
G
L
R
G
P
D
A
FFNEV
D
K
S
P
T
V
L
S
Q
I
-------
L
A
L
V
T
T
S
-
Q
V
C
R
H
P
H
P
L
V
Q
--
L
L
Y
M
E
I
L
V
R
Y
A
S
F
F
D
-------
Y
E
S
A
A
I
P
A
L
I
E
Y
-
F
---
V
G
---
P
RGIHNTNERV
R
P
R
A
W
Y
L
F
Y
R
F
V
K
S
I
K
K
Q
V
V
N
Y
T
E
S
S
L
A
M
L
G
D
L
L
N
I
S
V
S
P
V
TDAPVP
T
L
N
S
S
I
R
N
S
D
F
N
S
Q
L
Y
L
F
E
T
V
G
V
L
I
S
S
G
N
L
T
P
E
E
Q
A
L
Y
C
-----
D
S
L
I
N
A
L
I
G
K
A
N
A
-
A
---------------
L
S
S
D
L
S
E
N
I
---
I
S
V
Y
C
S
L
M
A
I
G
N
F
A
K
G
-
F
P
A
R
G
E
E
V
A
W
L
A
S
F
N
K
-------
A
S
D
E
I
F
L
I
L
D
R
M
G
F
N
E
D
I
R
G
A
V
R
F
T
S
G
R
I
INVV
G
P
D
M
L
P
K
V
P
Q
L
I
S
I
L
L
N
S
I
D
M
N
E
L
V
D
V
L
S
F
I
S
Q
L
I
H
----
I
Y
K
D
N
M
M
E
I
T
N
R
M
L
P
T
L
L
M
R
I
F
S
S
L
S
A
T
D
D
A
V
K
Q
N
D
L
R
K
S
Y
I
S
F
I
L
Q
L
L
N
K
G
F
G
S
I
L
F
T
E
E
N
Q
V
Y
F
D
P
L
I
N
S
I
L
H
F
A
P
A
T
Q
K
S
S
I
A
L
V
S
K
M
V
S
L
A
G
F
E
N
F
T
L
S
L
T
P
L
C
F
E
M
P
V
N
L
V
V
L
G
E
L
A
G
L
Q
K
I
I
L
E
K
L
G
D
I
Y
K
S
Y
L
V
T
VYFPTD
V
M
A
S
E
Y
L
Q
AIQALKS
34
HHSearch
45.25
14%
-88
- C2 -
2CFQ
-
LACY_ECOLI
A:
[16-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
-
H
-
D
I
N
H
I
--
S
K
S
D
T
G
I
I
F
A
A
---
I
S
L
F
S
L
L
F
--------
Q
P
L
F
G
L
L
S
D
K
L
G
-
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
---
F
F
I
F
I
F
G
P
L
L
-------------------------------------------------------
Q
Y
N
I
L
V
G
S
I
V
G
-----
G
I
YLGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
I
---------------------------------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
-
F
-
F
A
K
T
D
A
P
S
S
A
T
V
----------
A
N
A
V
--------------------------
G
---
A
N
H
-------
S
A
F
S
L
K
L
-
A
L
E
L
F
R
Q
P
K
L
W
--
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
-------
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
---
G
----------
T
R
V
F
G
Y
V
T
T
M
G
E
L
-
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
-------
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
-----
Y
I
T
S
Q
F
E
V
R
F
S
A
T
-
I
---------------
Y
L
V
C
F
C
F
F
K
---
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
-
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
-------
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
40.86
11%
-108
- C2 -
1PW4
-
GLPT_ECOLI
A:
[28-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
---
E
-
Q
G
F
--
S
R
G
D
L
G
F
A
L
S
G
---
I
S
I
A
Y
G
F
S
--------
K
F
I
M
G
S
V
S
D
R
S
N
-
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
---
M
L
F
M
G
F
V
P
W
A
T
----------------------------------------------------
S
S
I
A
V
M
F
V
L
L
F
L
C
-----
G
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
-------------------------
N
------
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
-
M
M
R
D
T
P
Q
S
C
G
L
P
----------
P
I
E
E
Y
K
N
-
D
-------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
--
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
-------
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
---
A
----------
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
-
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
-------
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
-----
M
L
I
G
L
H
A
L
E
L
A
P
K
-
K
---------------
A
A
G
T
A
A
G
F
T
---
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
-
G
Y
T
-
V
D
F
F
G
W
D
G
G
F
M
V
-------
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
----
L
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
37.89
10%
-117
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[36-178]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
-------
N
D
I
L
L
P
Q
F
Q
Q
-
A
-
F
---
T
L
---
T
----------
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
-
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
--
Y
K
A
G
I
I
T
-------
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
----------------------------------------------------------------------------------------------------------------------------------------
I
M
----
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
----
H
F
R
L
N
L
A
Q
T
F
N
S
-
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
----------------------------------------
37
HHSearch
37.44
8%
-134
- C2 -
3WDO
-
?
A:
[12-159]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
--
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
-------
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
---
G
A
---
S
----------
E
A
L
I
G
I
A
I
G
I
Y
G
L
-
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
--
K
P
L
I
V
G
-------
G
L
A
V
F
A
A
G
S
V
I
A
A
---
L
----------------------------------------------------------------------------------------------------------------------------------------
S
D
----
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
--
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
----
T
K
A
M
A
F
I
G
V
S
F
G
-
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
----------------------------------------
49
HHSearch
35.47
30%
150
- C4 -
1CGJ
-
ISK1_HUMAN
I:
[7-40]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
C
Y
N
E
L
N
---------------
G
C
T
L
-
E
Y
R
P
---
V
C
G
T
D
G
D
T
Y
P
N
E
C
V
L
C
-
F
E
N
-
R
K
R
Q
T
S
I
L
I
Q
K
S
-------
G
P
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
35.17
38%
144
- C4 -
2ERW
-
?
A:
[6-35]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
---------------
A
C
F
R
N
-
Y
V
P
---
V
C
G
S
D
G
K
T
Y
G
N
P
C
M
L
N
-
C
A
A
-
Q
T
K
V
P
G
L
K
L
V
H
E
-------
G
R
C
Q
R
S
N
V
E
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
34.43
30%
113
- C4 -
1TGS
-
ISK1_PIG
I:
[9-49]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
T
S
E
-
V
---------------
S
G
C
P
K
I
Y
N
P
---
V
C
G
T
D
G
I
T
Y
S
N
E
C
V
L
--
C
S
E
-
N
K
K
R
Q
T
P
V
L
I
Q
K
-------
S
G
P
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
33.53
23%
65
- C4 -
1TGS
-
ISK1_PIG
I:
[1-56]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
P
Q
R
-----
E
A
T
C
T
S
---
E
V
S
G
-
C
---------------
P
---
K
I
Y
N
P
---
V
C
G
T
D
G
I
T
Y
S
N
E
C
V
L
C
-
S
E
N
-
K
K
R
Q
T
P
V
L
I
Q
K
S
-------
G
P
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
33.38
44%
213
- C4 -
1LDT
-
LDTI_HIRME
L:
[4-30]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
---------------
A
C
P
K
-
I
L
K
P
---
V
C
G
S
D
G
R
T
Y
A
N
S
C
I
A
R
-
C
N
G
-
V
S
I
K
S
E
G
S
C
P
T
G
-------
I
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
32.84
23%
69
- C3 -
1VFI
-
VBP2_ASCSS
A:
[1-95]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
F
A
P
V
D
C
KGQC
T
T
P
C
E
P
L
T
A
C
K
E
K
-
C
A
E
S
C
ETSAD
K
K
T
C
R
R
N
C
K
K
A
D
C
E
P
Q
D
K
V
C
D
A
C
R
M
K
C
H
K
A
C
R
A
A
N
C
A
S
-
E
C
P
K
H
E
H
K
S
D
T
C
-------
R
A
C
M
K
T
N
C
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
32.82
41%
164
- C4 -
1TBR
-
THBI_RHOPR
R:
[60-90]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
D
G
D
E
Y
K
P
---
V
C
G
S
D
D
I
T
Y
D
N
N
C
R
L
E
-
C
A
S
-
I
S
S
S
P
G
V
E
L
K
H
E
-------
G
P
C
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
32.23
30%
68
- C4 -
2F3C
-
?
I:
[5-48]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
C
---------------
A
C
P
R
V
-
L
H
R
---
V
C
G
S
D
G
N
T
Y
S
N
P
C
T
L
D
-
C
A
K
-
H
E
G
K
P
D
L
V
Q
V
H
E
-------
G
P
C
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
32.21
12%
-91
- C2 -
1PW4
-
GLPT_ECOLI
A:
[273-431]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
W
S
P
T
Y
L
-
K
E
V
-
K
H
F
--
A
L
D
K
S
S
W
A
Y
F
L
---
Y
E
Y
A
G
I
P
G
--------
T
L
L
C
G
W
M
S
D
K
V
F
-
R
G
N
R
G
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
------------------------------------------------------
G
N
P
T
V
D
M
I
C
M
I
V
I
-----
G
F
----
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
--------------------------------
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
-
I
-
V
V
M
I
G
E
K
R
R
H
E
Q
----------
L
L
Q
E
L
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
31.51
36%
144
- C4 -
2ERW
-
?
A:
[4-34]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
-
C
---------------
A
C
F
R
-
N
Y
V
P
---
V
C
G
S
D
G
K
T
Y
G
N
P
C
M
L
N
-
C
A
A
-
Q
T
K
V
P
G
L
K
L
V
H
E
-------
G
R
C
Q
R
S
N
V
E
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------