@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO1B3_HUMAN: (2015-12-12 )
MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN
Atome Classification :
(20 SA)
----.........10........20........30........40....---....50....-...-.60........70........80........90........100-.........---110.......120.......130.......140.......150.......160.......170.......180----.......190.......200.......210-.......220...------.....230.......240.......250...----.....260.......270.....-.-.280.......290.......300.......310.......320......-.330.......340.......350.......360---.....-.---..370-..------......380.......390.......400-.........--410.......420.......430.......440.......450.......460-.......470.......480....---...490.......500.......510.......520.......530.......540...--....550.......560.......570.......580.......590.......600.......610.......620.......630.......640..--------.....650.......660.......670.......680.....-..690.......700----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
D
Q
H
Q
H
L
N
K
T
A
E
SAS
S
E
K
K
K
T
RRCN
G
F
K
M
F
L
A
A
L
S
F
S
Y
I
A
K
A
LG
G
---
I
I
M
K
I
S
I
T
Q
I
-
E
R
R
-FD
I
S
S
S
L
A
G
L
IDGSFEI
G
N
L
L
V
I
V
F
V
S
Y
F
G
SKLHR
P
K
L
I
G
I
G
---
C
L
L
MG
T
G
S
I
---
L
T
S
L
P
H
F
F
M
G
Y
Y
RYSKETHINPSENST
S
S
L
S
T
C
L
INQTLSFNGT
S
P
E
I
V
E
K
D
C
V
KESG
S
H
M
W
I
Y
V
F
M
G
N
M
L
R
G----IGET
P
I
V
P
L
G
I
S
Y
I
D
D
F
A
KEGHS
S
L
Y
L
GSL-NAI
G
M
I
G
P
-
V
I
G
F
------
A
L
G
S
L
F
A
K
M
Y
V
D
I
G
Y
V
D
L
S
T
I
R
ITPK-DSR
W
----
V
G
A
W
W
L
G
F
L
V
S
G
L
F
S
I
I
S
SI
P
F
F
-
F
-LPKNPNKPQK
E
R
K
I
S
L
S
L
H
V
L
KTNDDRNQTANLTNQGK
N
V
T
K
N
V
T
G
F
F
Q
S
-
L
K
S
I
LTN
P
L
Y
V
I
F
L
L
L
T
L
L
Q
V
S
S
F
I
G
S
F
T
Y
V
F
K
----
Y
M
E
Q
Q
-Y---GQSA--SH------A
N
F
L
L
G
I
I
TI
P
T
V
A
T
G
M
F
L
G
G
F
I
I
K
K
F
---
K
L
S
L
V
G
I
A
K
--
F
S
F
L
T
S
M
I
S
F
L
F
Q
L
L
Y
F
P
LICESK
S
V
A
G
L
T
L
T
YDGNNSVASHVD
V
P
L
S
Y
CNSE-CNCDESQWEPVCGNN
G
I
T
Y
L
S
P
C
L
---AGCKSSSGI
K
K
H
T
V
F
Y
N
C
S
C
V
E
V
TGLQNRNYSAHLGECPRDNTC
T
R
K
F
F
I
Y
V
A
I
Q
V
I
N
S
--
L
F
SATG
G
T
T
F
I
L
L
T
V
K
IV
Q
P
E
L
K
A
L
A
M
G
F
Q
S
M
V
I
R
T
L
G
G
I
L
A
P
I
Y
F
G
A
L
I
D
K
T
C
M
KWSTNSCGA
Q
G
A
C
R
I
Y
N
S
V
F
F
G
R
V
Y
L
G
L
S
I
A
L
R
F
P
A
L
V
L
Y
I
V
F
I
--------
F
A
M
K
K
K
FQGKDTKASDN
E
R
K
V
M
D
EAN
L
E
FLNNG
E
H
FVPSAGTD-S
K
T
C
N
LDMQDNAAAN----
24
Fugue
84.34
14%
-89
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
--------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
-
N
L
S
-
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
---
G
S
A
W
P
E
L
G
F
T
---------------------------
S
I
N
P
D
N
T
V
P
V
Y
L
A
G
-----
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
----
L
A
-
S
M
L
S
P
M
Y
I
A
-------
E
L
A
P
A
H
I
R
G
K
L
-
V
S
F
N
Q
F
A
I
-
I
F
G
Q
------
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
----------
D
A
-
S
W
L
N
----
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
-
T
-
V
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
---
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
-
G
G
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
-
I
N
V
V
L
Y
----
Y
A
P
E
V
-
F
---
K
T
L
G
AS
T
D
------
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
--
M
A
I
G
M
F
S
L
G
T
A
F
Y
--------------------------------------------------------------------------------------------------------------
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
--
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
-
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
--------------------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
--------
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-------------------------------------------
25
Fugue
79.87
16%
-83
- C2 -
3UFB
-
?
A:
[12-495]
ADQP
M
T
T
A
Q
Q
L
G
A
I
V
K
S
S
R
Q
I
M
R
K
D
K
G
L
N
G
D
L
D
R
L
P
M
L
T
W
I
M
F
L
K
F
L
D
D
---
L
E
Q
M
R
E
T
E
A
V
-
L
E
G
-
K
S
F
Q
P
A
I
E
A
P
Y
R
----------------
W
R
D
W
A
A
I
E
G
G
I
-----------
T
G
D
E
---
L
I
A
F
I
N
---------
N
D
E
A
M
R
P
D
G
T
R
G
I
G
L
F
A
Y
L
R
S
L
Q
G
D
N
G
G
D
R
R
D
V
I
-
A
T
V
F
K
G
M
Q
N
R
M
I
N
G
Y
L
L
R
D
V
V
D
K
----
I
N
G
-------
I
H
F
N
S
S
E
E
M
H
T
L
S
R
L
Y
E
T
M
L
-
R
E
M
R
D
A
A
G
-
D
S
G
--------------
E
F
Y
T
P
R
P
V
V
R
F
M
V
E
V
M
D
P
Q
-
L
G
E
S
----
V
L
D
P
A
C
G
---------------------------------------------------------------
T
G
------------------------------
G
F
L
V
E
A
F
E
----
H
L
E
R
Q
-
C
---
K
T
V
E
--
D
R
------
E
V
L
Q
--------------------------
E
S
S
I
F
G
G
E
A
K
S
L
P
Y
L
L
V
Q
M
N
L
L
L
H
G
L
E
Y
P
R
I
D
P
E
N
S
L
R
F
P
L
R
E
M
----
G
D
K
D
R
V
D
V
I
L
T
--------------------------
N
P
P
F
---
G
G
-
E
E
E
K
G
I
L
G
------------------
N
F
P
E
D
M
-----
Q
T
A
E
T
A
M
L
F
L
Q
L
I
M
R
K
L
K
R
PG
H
G
S
D
N
G
G
R
A
A
V
V
V
P
N
G
T
L
F
S
D
G
I
S
A
R
I
K
E
E
L
L
K
N
F
N
L
H
T
I
V
R
------
L
P
E
G
V
F
A
P
Y
T
D
I
A
---------
G
N
L
L
F
F
D
R
---------
S
G
P
T
D
D
I
W
Y
Y
Q
I
T
V
P
EGRKK
Y
T
K
T
K
P
M
E
S
H
E
F
D
E
C
L
N
W
W
S
N
R
I
V
N
Q
N
A
W
K
E
S
A
S
E
I
I
K
Y
S
E
S
G
Q
L
I
D
V
N
L
D
R
K
N
P
N
S
L
E
VLEH
30
HHSearch
64.21
17%
-87
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[31-325]
-------------------------------------
L
C
S
L
F
F
L
W
A
V
A
N
---
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
---
L
F
W
P
A
A
E
I
---------------------------------------------------
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
----
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
N
S
F
G
A
-
I
I
A
V
------
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
-
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
-
L
-
T
-
K
F
P
A
L
Q
S
D
N
H
S
D
A
---------------------------
K
Q
G
S
F
S
A
S
-
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
----
Y
A
V
E
E
I
P
---
G
M
T
A
--
G
F
------
A
A
N
Y
L
T
G
T
M
V
-
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
---
A
P
H
K
V
L
A
A
Y
--
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
-
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
---
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
59.88
11%
-55
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
----
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
---
L
A
M
P
Y
L
------
V
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
---
F
M
G
F
V
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
-----------
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
---------
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
-
C
A
I
L
V
A
L
F
-
A
F
A
M
MRDTPQ
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
-
K
L
L
W
----
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
---
L
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
-
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
----
G
P
V
M
L
-
I
---
G
L
H
A
--
L
E
LAPKKA
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
---
V
D
F
F
G
W
D
G
G
--
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
51.83
14%
-76
- C2 -
2GFP
-
EMRD_ECOLI
A:
[21-270]
---------------------------------------------
Q
M
A
Q
---
T
I
Y
I
P
A
I
A
D
M
-
A
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
---
V
A
V
T
T
S
S
------------------------------------------------------
L
T
V
L
I
A
A
S
A
M
Q
G
----
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
I
L
V
S
P
-
L
L
A
P
------
L
I
G
G
L
L
D
T
M
W
---------------------------
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
-
R
W
M
P
E
T
R
P
V
D
A
-
P
R
--------------------------------
T
R
L
L
T
S
-
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
----
L
M
G
A
V
-
L
---
G
L
S
S
--
M
T
------
V
S
I
L
F
I
L
P
I
P
-
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
---
S
T
L
M
W
Q
S
V
I
--
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
-
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
---
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
49.10
13%
-79
- C2 -
2CFQ
-
LACY_ECOLI
A:
[18-289]
-------------------------------------------
F
Y
F
F
I
M
---
G
A
Y
F
P
F
F
P
I
W
-
L
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
---
I
F
I
F
G
P
L
L
-----------------------------------------------------
Q
Y
N
I
L
V
G
S
I
V
G
G
IYLG
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
-
R
M
F
G
C
V
G
W
-
A
L
G
A
------
S
I
V
G
I
M
F
T
I
----------------------------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
-
F
-
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
--
G
------------------
A
----
N
H
S
A
F
S
L
K
L
-
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
----
F
F
T
S
F
-
F
AT
G
E
Q
G
T
--
R
V
------
F
G
Y
V
T
T
M
G
E
L
-
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
---
G
G
K
N
A
L
L
L
A
--
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
-
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
---
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
47.90
12%
-90
- C2 -
1PW4
-
GLPT_ECOLI
A:
[38-319]
-----------------------------------------
Y
A
A
Y
Y
L
V
R
---
K
N
F
A
L
A
M
P
Y
L
-
V
-
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
---
F
M
G
F
V
P
W
A
T
--------------------------------------------------
S
S
I
A
V
M
F
V
L
L
F
L
C
G
----
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
A
H
N
V
G
G
-
G
I
P
P
------
L
L
F
L
L
G
M
A
W
F
--------------------------
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
-
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
--------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
----
Y
L
K
E
V
-
K
---
H
F
A
L
--
D
K
------
S
S
W
A
Y
F
L
Y
E
Y
-
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
---
F
R
G
N
R
G
A
T
G
--
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
-
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
---
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
45.90
16%
-92
- C2 -
3WDO
-
?
A:
[21-180]
-------------------------------------------
L
R
M
L
G
M
---
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
---
I
A
A
L
S
D
S
------------------------------------------------------
I
W
G
I
I
L
G
R
A
L
Q
G
----
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
I
T
F
-
A
I
A
M
------
V
L
G
P
I
I
T
H
K
L
---------------------------
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
-
W
-
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
-
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
----
I
I
Y
A
E
-
V
---
K
R
K
M
--
K
Q
------
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
---
V
G
V
Q
L
F
F
V
A
--
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
-
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
---
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
--
R
Q
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
43.22
20%
-40
- C2 -
4LDS
-
?
A:
[113-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
-
G
S
L
N
Q
L
M
I
-
T
I
G
-----------
I
L
A
A
Y
L
V
N
Y
A
F
A
D
I
E
G
W
R
----------------
W
M
L
G
L
A
V
--
V
P
S
V
I
L
L
V
G
I
Y
-
F
-
M
P
E
S
P
R
W
L
L
E
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
E
I
N
A
I
S
E
S
T
W
T
V
-
I
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
--
Q
F
I
G
I
N
A
V
I
F
Y
SSSI
F
A
K
A
G
-
L
---
G
E
A
A
--
S
----------
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
---
I
D
R
K
K
L
L
V
G
--
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
-
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
---
V
S
L
F
F
P
I
L
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
40.55
30%
60
- C3 -
2ERW
-
?
A:
[6-52]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
F
R
N
-
Y
V
P
V
C
G
S
D
G
K
T
Y
G
N
P
C
M
---
L
N
C
A
A
Q
T
--------------
K
V
P
G
L
K
----
L
V
H
E
G
R
C
Q
R
S
N
V
E
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
39.44
8%
-105
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[36-178]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
----
F
Q
Q
A
--
F
---
T
L
T
N
--
F
Q
------
A
G
L
I
Q
S
A
F
Y
F
-
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
---
S
Y
--
K
A
G
I
I
--
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
-----------------------------------------------------------------------------------------------------------
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
--
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
-
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
--------
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
-
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
----
34
HHSearch
36.11
11%
-65
- C2 -
1PW4
-
GLPT_ECOLI
A:
[274-410]
--------------------------------------------------------
D
W
S
P
T
Y
L
K
E
V
-
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
----------------------------------------------------
G
N
P
T
V
D
M
I
C
M
I
V
I
G
----
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
------
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
-
V
I
L
L
----
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
34.57
27%
47
- C3 -
2ERW
-
?
A:
[4-50]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
-
C
A
C
F
R
-
N
Y
V
P
V
C
G
S
D
G
K
T
Y
G
N
P
C
M
---
L
N
C
A
A
Q
T
K
V
P
G
L
K
L
V
H
E
G
R
C
Q
R
S
N
V
E
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
33.10
30%
53
- C1 -
2R3A
1
SUV92_HUMAN
A:
[87-131]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
Q
K
C
C
P
A
E
--
A
G
V
L
L
A
Y
N
K
N
Q
Q
I
K
I
P
P
G
T
P
I
Y
E
C
N
S
R
-
C
Q
C
G
-----
P
D
C
P
N
R
I
V
Q
K
G
T
Q
Y
S
---
L
C
I
F
R
T
S
N
G
R
G
W
G
V
K
T
L
V
K
I
K
R
M
S
F
V
M
E
Y
V
G
E
V
I
T
S
E
E
A
E
R
R
G
Q
F
Y
D
N
K
G
I
T
Y
L
F
D
L
D
Y
--
E
S
D
E
F
T
V
D
A
A
R
Y
G
N
V
S
H
F
V
N
H
S
C
D
P
N
L
Q
V
F
N
V
F
I
D
N
L
D
T
R
L
P
R
I
A
L
F
S
T
R
T
I
N
A
G
E
E
L
T
F
D
Y
Q
M
K
G
S
G
R
V
R
T
V
C
K
C
G
A
V
T
C
R
G
Y
L
N
------------------------------------------------------------------------------------
35
HHSearch
32.01
11%
-40
* C2 *
2CFQ
-
LACY_ECOLI
A:
[257-376]
----------------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
---
G
S
S
F
A
T
S
------------------------------------------------------
A
L
E
V
V
I
L
K
T
L
H
M
----
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
------
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
-
T
L
I
S
----
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
30.84
37%
175
- C3 -
2F3C
-
?
I:
[5-34]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
C
A
C
P
R
-
V
L
H
R
V
C
G
S
D
G
N
T
Y
S
N
P
C
T
---
L
D
C
A
K
H
E
G
K
P
D
L
V
Q
V
H
E
G
P
C
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
29.85
31%
148
- C3 -
1CGJ
-
ISK1_HUMAN
I:
[6-41]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
K
C
Y
N
E
L
N
G
C
T
L
-
E
Y
R
P
V
C
G
T
D
G
D
T
Y
P
N
E
C
V
---
L
C
F
E
N
R
K
R
Q
T
S
I
L
I
Q
K
S
G
P
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
29.68
45%
227
- C3 -
1Y1B
-
IELA_ANESU
A:
[11-41]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
D
P
V
C
G
S
D
G
I
T
Y
G
N
A
C
M
L
L
G
A
S
C
R
S
D
T
P
I
E
L
V
H
K
G
R
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
29.37
41%
213
- C3 -
1LDT
-
LDTI_HIRME
L:
[3-31]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
C
A
C
P
K
-
I
L
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
I
---
A
R
C
N
G
V
S
I
K
S
E
G
S
C
P
T
G
I
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
29.29
42%
238
- C3 -
1TGS
-
ISK1_PIG
I:
[9-36]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
T
S
E
-
V
S
G
C
P
K
I
Y
N
P
V
C
G
T
D
G
I
T
Y
S
N
E
C
V
---
L
C
S
E
N
K
K
R
Q
T
P
V
L
I
Q
K
S
G
P
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------