@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO4A1_HUMAN: (2015-12-12 )
MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLLYKVLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60........70........80........90--------....----------.....100.......110......-.120.......130-.-.-.....140.......150.......160.......170.......---180.---......190....----...200.......210.......220........230.......240----.......250.......260.......270....-...280.......290.----......300-..---.--......310......------.320.......330.......340.......350.......360.......370-...-.----...380-........390.......400.......410----..-.---.....420.......--430.......440.....---..450......--.460.......470.......480.......490.......500....-.-..510.......520--........530..----...-..540.......550.........560.......570--.......580..---.....590....-----...600.-------------......610........620.......630.......640.......650.....----..660.......670.......680.......690.......700.......710.......720-----------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------M
P
L
H
QLGDKPLTFPSP
N
S
A
M
ENGLDHTPPSRRASPGTPLS
P
G
S
L
R
S
AAHSPLDT
S
K
Q
P
L
C
Q
L
W
A
E
KHGARGT
H
E
V
R
Y
V
SAGQ
S
V
A
C
GWWA---------FA
P
P
----------
C
L
Q
V
LNTP
K
G
I
L
F
F
L
C
A
A
A
F
LQGM-TV
N
G
F
I
N
T
V
I
T
S
L
E
-
R
-
R
-
Y
D
L
H
S
YQSGLIASS
Y
D
I
A
A
C
L
C
L
T
F
V
S
Y
FGGSGHKP
R
W
L
G
W
G
V
L
L
---
M
GTG---
S
L
V
F
A
LPHFTA
G
R
----
Y
E
V
E
LDAGVRTCPANPGAVCADSTS-GL
S
R
Y
Q
L
V
F
M
L
G
Q
F
L
H
GVGAT----
P
L
Y
T
L
G
V
T
Y
L
D
E
N
V
KSSCS
P
V
Y
I
A
I
F
Y
T
A
A
I
LGP-
A
A
G
Y
L
I
G
G
A
L
L
N
I
Y
T
E
M----GRRTELT---TE---S--P
L
W
V
G
A
W
W
V
G
F
LGS
G
------
A
A
A
F
F
T
AVPILGYPRQLPGSQ
R
Y
A
V
M
R
A
A
E
M
H
Q
L
KDSSRGEASNPDF
G
K
T
I
R
DL-P
L
S
-
I
----
W
L
L
LK--NP
T
F
I
L
L
C
LAGAT
E
A
T
L
I
TGMSTF
S
P
K
F
L
E
-----
S
Q
-F---SLS
A
S
E
A
A
T
L
F
G
Y
L
V
--
V
PAGGGG
T
F
L
G
G
F
F
V
N
K
L
---RL
R
G
S
A
V
I
K
F
C
--
L
F
C
T
V
V
S
L
L
G
I
L
V
F
SLHCPSVPMAGVTASYGGSLLPEGH
L
N
LTAPCNA-A-CSCQPEHYSPVCGS---DG
L
M
Y
F
S
L
CHAGC----PAA-TETNV
D
G
Q
K
V
Y
R
D
--CSCI
P
Q
N
L
S
SGFGHATAGKC
T
S
--
T
CQRK
P
L
L
L
V
F
I
---
F
V
V
I
F
F
T
F
L
S
S
I
-----
P
A
L
T
A
T
L
-------------
R
C
VRDP
Q
-
R
S
F
A
L
G
I
Q
W
I
V
V
R
I
LGGIPG
P
I
A
F
G
W
V
I
D
K
A
C
L
L
W
Q
D
QCGQQG
S
C
L
V
----
Y
QNSA
M
S
R
Y
I
L
I
M
G
L
L
Y
K
V
L
G
V
L
F
F
A
I
A
C
F
L
YKPLSESSD
G
L
E
T
CLPSQSSAPDSA
T
D
S
Q
L
QSSV-----------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
80.26
12%
-93
- C2 -
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
V
Q
D
D
L
P
A
W
P
E
L
L
Q
A
L
I
E
S
L
K
S
G
N
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
V
D
I
N
S
I
L
P
I
F
Q
S
G
F
T
D
A
S
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSK
L
G
I
L
----------
L
P
S
L
L
N
S
L
P
R
F
L
D
D
G
K
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
A
P
K
L
F
K
-
D
-
M
-
F
D
Q
I
I
Q
F
T
D
M
V
I
K
N
K
D
L
E
P
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
---
Y
G
Q
T
---
L
V
M
V
T
L
I
M
M
T
----------
E
V
S
I
D
D
D
D
A
A
E
W
I
E
S
D
D
T
D
D
E
E
-
E
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
L
G
G
E
----
Y
L
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
S
T
E
W
R
E
R
F
A
A
M
M
A
L
S
S
A
A
E
-
G
C
A
D
V
L
I
G
E
I
P
K
I
L
D
M
V
----
I
P
L
I
N
D
P
---
H
P
---
R
--
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
T
S
E
C
T
S
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
F
A
S
K
D
I
L
E
P
Y
L
D
S
L
L
T
N
L
-
L
V
L
-
L
Q
SNK
L
Y
V
Q
E
--
Q
A
L
T
T
I
A
F
I
A
E
A
A
K
N
K
F
I
K
Y
Y
D
T
L
M
P
L
L
L
N
V
L
K
VN
S
V
-
L
---
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
K
E
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
SD
A
L
R
S
Y
L
E
Q
S
W
S
--
R
I
C
R
I
L
G
D
D
F
V
P
L
L
P
I
V
I
P
P
L
L
I
T
A
K
A
T
Q
D
V
G
L
I
E
E
E
E
A
A
N
F
Q
Q
Y
P
D
W
-
D
-
V
V
Q
V
Q
G
K
H
I
A
I
H
T
S
V
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
----
T
L
L
R
G
Q
F
A
V
Y
V
K
E
V
M
E
E
I
A
L
P
S
L
D
F
Y
L
H
D
G
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
A
E
E
L
V
L
L
---
W
H
K
A
S
S
K
L
I
G
G
L
M
S
EPM
P
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
GD
N
C
L
S
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
D
R
D
E
Y
N
E
D
F
T
D
E
D
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
GH
Y
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
L
E
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
Y
E
Q
T
A
S
M
K
N
A
F
I
P
K
V
T
E
C
L
I
S
P
D
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
YAPSTYADVCIPT
L
D
T
L
V
Q
I
V
DGSKLEEN
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
NSNIPD
T
Y
T
A
N
W
F
K
T
LPTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
31
HHSearch
53.40
13%
-96
- C4 -
1PW4
-
GLPT_ECOLI
A:
[27-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
-
V
-
R
K
N
F
A
L
A
M
P
Y
L
V
---
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
---
A
A
A
V
---
M
L
F
M
G
F
V
P
W
A
-----------------------------------
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
----
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
-----------------------------
N
D
W
H
A
A
L
Y
M
P
A
------
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
--------------------
T
A
-
K
Q
I
F
M
----
Q
Y
V
L
P
--
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
-----
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
--
Y
-
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
---
F
R
G
N
R
G
A
T
G
V
F
--
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
-
A
-
P
K
K
A
A
G
T
A
A
G
F
T
G
L
---
F
G
Y
L
G
G
S
V
A
A
S
A
I
----
V
G
Y
-
T
V
D
F
F
G
W
D
G
G
F
M
V
--
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
--
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
51.88
9%
-78
- C1 -
2A5Y
1
CED4_CAEEL
B:
[1-543]
------------------------------------------------------------------------------------------------------------------------------------------------
M
L
C
E
I
E
C
R
A
L
S
T
A
H
T
R
L
I
H
D
F
E
P
R
D
A
L
T
Y
L
E
G
------------------------------------------------------------
K
N
I
-
F
T
E
D
H
S
E
L
I
S
K
M
S
T
-
R
-
L
-
E
R
I
A
N
F
L
R
I
Y
R
R
Q
A
S
E
L
----------------------------------
G
---
P
L
I
D
F
F
N
Y
N
N
Q
S
H
----
L
A
D
F
L
E
D
Y
I
D
F
A
I
N
E
P
D
L
L
R
P
V
V
I
A
-
P
Q
F
S
R
Q
M
L
D
R
K
L
L
L
G
N
V
P
K
Q
M
----
T
C
Y
--
I
R
E
Y
H
V
D
R
V
I
K
K
L
D
E
M
C
D
L
D
S
F
F
L
F
L
H
G
--
R
A
G
S
G
K
S
V
I
A
S
Q
A
L
S
K
S
----
D
Q
L
I
G
I
N
---
Y
D
---
S
--
I
V
W
L
K
---
D
S
G
T
A
P
K
------
S
T
F
D
L
F
T
D
I
L
L
M
L
K
S
E
D
D
L
L
N
F
P
S
V
E
H
V
T
S
V
V
L
K
R
M
I
C
N
A
L
I
D
R
P
N
T
L
F
V
F
D
D
V
V
Q
E
E
-
T
----
I
R
W
A
Q
E
L
R
L
R
C
L
V
T
T
R
D
V
E
I
S
N
A
A
S
Q
T
C
E
F
I
E
V
T
---------------
S
L
E
I
D
E
C
Y
D
F
L
E
A
Y
G
--
M
P
M
P
-----------
E
K
E
---
E
D
V
L
N
K
T
I
E
L
S
SG
N
P
A
T
L
M
M
F
F
K
S
C
-------------------
E
P
K
T
F
E
K
M
A
Q
L
N
N
K
L
E
S
-
R
-
G
L
V
G
V
E
C
I
T
P
Y
S
Y
K
---
S
L
A
M
A
L
Q
R
C
V
E
V
L
----
S
-------
D
E
D
R
S
A
L
A
F
--
A
V
V
M
P
P
G
--------------
V
--
D
I
P
V
K
L
W
S
C
V
I
P
VEQ
L
D
D
E
V
A
D
R
L
K
R
L
-----
S
K
R
G
A
L
L
-------------
S
G
K
R
M
P
V
-
L
T
F
K
I
D
--------------------------
H
I
I
H
M
F
L
K
H
V
V
D
A
Q
T
----
I
A
N
G
I
---------------------------
S
I
L
E
Q
R
L
L
E
I
E
T
V
I
R
P
E
D
F
P
K
F
M
Q
L
H
Q
K
F
Y
D
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
51.86
15%
-90
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[30-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
C
S
L
F
F
L
W
A
V
-
A
-
N
N
L
N
D
I
L
L
P
Q
F
Q
-
Q
-
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
F
L
---
Y
A
L
G
---
A
A
L
F
W
P
A
A
E
------------------------------------
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
----
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
----
Q
S
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
------
A
I
V
L
L
V
A
L
L
I
M
L
T
-
K
F
P
A
L
Q
S
D
N
H
S
-
D
---------------------
A
K
Q
G
S
F
-
S
A
S
-
L
----
S
R
L
A
R
--
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
-----
E
E
I
P
---
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
--
V
-
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
---
A
P
--
H
K
V
L
A
A
Y
--
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
-
T
-
K
Y
G
S
S
F
I
V
M
T
I
I
G
G
---
G
I
V
T
P
V
M
G
F
V
S
D
A
----
A
G
N
-
I
P
T
A
E
L
I
P
A
L
C
F
A
--
V
I
F
I
F
A
R
F
R
S
Q
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
49.32
9%
-76
- C4 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
P
A
PHKARLPAAE
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
-
L
V
R
K
N
F
A
L
A
M
P
Y
L
--
V
-
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
---
A
A
A
V
---
M
L
F
M
G
F
V
P
W
A
T
S
S
IAV
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
----
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
-
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
EYKN
D
T
A
K
Q
I
F
---
M
Q
---
Y
--
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
------
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
-
R
G
N
-
R
----
G
A
T
G
V
--
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
-----
I
G
-
F
---
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
--
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
---
Y
L
G
G
S
V
A
A
S
A
I
--
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
45.11
14%
-116
- C4 -
3WDO
-
?
A:
[13-180]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
L
G
T
V
F
S
L
R
M
L
-
G
-
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
-
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
---
F
A
A
G
---
S
V
I
A
A
L
S
---------------------------------------
D
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
------
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
------------------------------
G
L
H
A
L
F
W
M
I
A
------
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
-
L
L
M
-
S
----
T
F
V
A
L
--
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
-----
P
F
-
I
---
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
--
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
---
F
W
Q
L
V
V
G
V
Q
L
F
--
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
-
I
-
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
---
M
L
A
A
V
W
L
A
V
A
S
T
M
----
K
E
P
-
P
Y
V
S
S
L
R
I
E
I
P
A
D
--
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
--
A
E
E
E
H
S
A
Y
V
K
I
D
---
S
K
V
T
N
R
F
E
V
E
Q
A
-----
I
R
Q
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
43.58
14%
-79
- C4 -
2GFP
-
EMRD_ECOLI
A:
[18-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
G
Q
M
-
A
-
Q
T
I
Y
I
P
A
I
A
D
M
A
-
R
-
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
M
S
I
---
F
M
L
A
---
T
L
V
A
V
T
T
---------------------------------------
S
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
----
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
------------------------------
N
W
R
A
C
Y
L
F
L
L
------
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
-
P
R
--------------------------
T
R
L
-
L
T
S
-
Y
----
K
T
L
F
G
--
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
-----
A
V
-
L
---
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
--
P
-
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
---
S
T
L
M
W
Q
S
V
I
C
C
--
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
-
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
---
I
G
S
G
V
L
A
S
L
S
A
M
L
----
P
Q
T
-
G
Q
G
S
L
G
L
L
M
T
L
M
G
--
L
L
I
V
L
C
W
L
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
40.78
39%
-11
- C3 -
2ERW
-
?
A:
[6-53]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
F
-
R
N
Y
V
P
V
C
G
S
---
D
G
K
T
Y
G
N
P
C
M
L
N
C
------
A
-
A
Q
T
K
V
P
G
L
K
L
V
H
E
--
G
R
C
Q
R
S
N
V
E
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
40.69
13%
-93
- C4 -
2CFQ
-
LACY_ECOLI
A:
[11-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
G
L
F
F
F
F
Y
F
F
-
I
-
M
G
A
Y
F
P
F
F
P
I
W
L
-
H
-
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
---
F
F
I
F
I
F
G
P
--------------------------------------
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
FCFN
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
I
-------------------------------
N
N
Q
F
V
F
W
L
G
S
------
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
-
A
V
------------------
G
A
N
H
S
A
F
S
-
L
K
L
-
A
----
L
E
L
F
R
--
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
-----
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
--
L
-
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
---
G
G
--
K
N
A
L
L
L
A
--
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
-
R
-
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
---
Q
L
A
M
I
F
M
S
V
L
A
G
N
----
M
Y
E
-
S
I
G
F
Q
G
A
Y
L
V
L
G
L
--
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
--
R
R
Q
V
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
40.53
16%
-121
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[36-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
-----
A
--
F
---
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
--
F
-
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
---
S
Y
--
K
A
G
I
I
T
G
--
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
----
E
I
-------------------------------------------------------------------------------------------------------------
M
N
Y
T
L
F
L
V
G
L
---
F
I
I
A
A
G
L
G
C
L
E
T
-----
A
A
N
P
F
V
T
-------------
V
L
G
P
E
S
S
-
G
H
F
R
L
N
L
A
Q
T
F
N
S
-
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
----
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
37.77
42%
70
* C3 *
2ERW
-
?
A:
[4-34]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
P
-
C
A
C
F
R
-
N
Y
V
P
V
C
G
S
---
D
G
K
T
Y
G
N
P
C
M
L
N
C
----
A
A
Q
-
T
K
V
P
G
L
K
L
V
H
E
G
R
--
C
Q
R
S
N
V
E
Q
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
37.67
13%
-77
- C4 -
1PW4
-
GLPT_ECOLI
A:
[273-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
W
S
P
T
Y
L
-
K
E
V
-
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
---
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
-------------------------------------
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
----
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
------------------------------
G
W
D
G
G
F
M
V
M
I
------
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
36.80
40%
85
- C3 -
3PIS
-
?
A:
[1-39]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
C
-
P
H
T
Y
K
P
V
C
G
A
---
N
G
E
V
Y
D
N
E
C
F
L
N
K
AGIE
P
A
E
-
S
W
E
T
C
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
35.42
35%
73
- C3 -
1TGS
-
ISK1_PIG
I:
[7-41]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
C
T
S
E
V
-
S
G
C
P
-
K
I
Y
N
P
V
C
G
T
---
D
G
I
T
Y
S
N
E
C
V
L
C
S
----
E
N
K
-
K
R
Q
T
P
V
L
I
Q
K
S
G
P
--
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
35.36
35%
91
- C3 -
1CGJ
-
ISK1_HUMAN
I:
[6-40]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
K
C
Y
N
-
E
L
N
G
C
T
-
L
E
Y
R
P
V
C
G
T
---
D
G
D
T
Y
P
N
E
C
V
L
C
F
----
E
N
R
-
K
R
Q
T
S
I
L
I
Q
K
S
G
P
--
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
35.31
46%
134
- C3 -
1LDT
-
LDTI_HIRME
L:
[4-31]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
P
K
-
I
L
K
P
V
C
G
S
---
D
G
R
T
Y
A
N
S
C
I
A
R
C
----
N
G
V
-
S
I
K
S
E
G
S
C
P
T
G
I
L
--
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
35.08
51%
148
- C3 -
1AN1
-
LDTI_HIRME
I:
[4-29]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
-
P
K
I
L
K
P
V
C
G
S
---
D
G
R
T
Y
A
N
S
C
I
A
R
C
----
N
G
V
-
S
I
K
S
E
G
S
C
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
35.00
39%
102
- C3 -
2F3C
-
?
I:
[6-33]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
P
R
-
V
L
H
R
V
C
G
S
---
D
G
N
T
Y
S
N
P
C
T
L
D
C
----
A
K
H
-
E
G
K
P
D
L
V
Q
V
H
E
G
P
--
C
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
34.60
45%
120
- C3 -
2SGP
-
I:
[10-40]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
T
P
E
-
Y
R
P
L
C
G
S
---
D
N
K
T
Y
G
N
K
C
N
F
-
C
----
N
A
V
-
V
E
S
N
G
T
L
T
L
S
H
F
G
--
K
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
34.28
7%
-115
- C4 -
3WDO
-
?
A:
[12-160]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
-----
A
L
-
Q
---
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
--
L
-
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
---
G
R
--
K
P
L
I
V
G
G
--
L
A
V
F
A
A
G
S
V
I
A
A
L
S
----
D
S
----------------------------------------------------------------------------------------------------------------
I
W
G
I
I
L
G
R
---
A
L
Q
G
S
G
--
A
I
A
A
-----
A
V
M
A
L
L
S
-------------
D
L
T
R
E
Q
N
-
R
T
K
A
M
A
F
I
G
V
S
F
G
-
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
----
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------