@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO4C1_HUMAN: (2015-12-12 )
MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKIVKEG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100......---.110.......120.......130.-..-.-...140.......150.......160.......170......---.180.---......190.......200.......210.......220.......230.......240..----.....250.......260.......-270......-.280.......290.......300....-....310--.........320.......330-..-.....340.......350-----.........360-----.........370..-.....380......--------.390.......400..------------..-...410-.---......420.......430-----.......440.-......450.......460.......-------470.......480.......490.......500.......510.....-..520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKSAKGIE
N
L
AFVPS
S
P
D
I
L
R
R
LSASPS
Q
I
E
V
S
ALSSDPQRENSQ
P
Q
ELQKPQEPQKSPEPSLPSAPPNV
S
E
E
K
L
R
SL
S
L
S
E
F
EEGSYGWRNF
H
P
Q
C
L
Q
R
CNTP
G
G
F
L
---
L
H
Y
C
L
L
A
V
TQG
I
V
V
N
G
L
V
N
I
S
I
S
T
V
-
E
K
-
R
-
Y
E
M
K
S
S
L
T
G
L
ISSSY
D
I
S
F
C
L
L
S
L
F
V
S
F
F
GERGHK
P
R
W
L
A
F
A
---
A
F
M
I
G
---
L
G
A
L
V
F
S
L
P
Q
F
FSGEY
K
L
G
S
L
F
E
D
T
C
VTTRNSTSCTSS
T
S
S
L
S
N
Y
L
Y
V
F
I
L
G
Q
L
L
LGAGG
T
----
P
L
Y
T
L
G
T
A
F
LDDSVPTHKS
S
L
Y
I
GT-
G
Y
A
M
S
I
L
G
P
-
A
I
G
Y
V
LGG
Q
L
L
T
I
Y
I
D
V
AMGEST-DVTE-DDPR
W
----
L
G
A
W
W
I
G
F
L
L
S
W
I
F
A
W
S
L
IIPF-SC-FPKHLPGT
A
E
I
QAGKT-------SQAHQSNSNA-------
D
V
K
FGKS
I
K
D
F
P
A
A
-
L
K
N
L
M
K
N
A
V
F
M
C
L
V
--------LSTSSE
A
L
I
TT
G
F
A
T
F
------------
L
P
-
K
F
I
E
N
Q-F---GL
T
S
S
F
A
A
TLGG
A
V
LI
P
G
A
-----
A
L
G
Q
I
L
G
G
F
L
V
-
S
K
F
R
M
T
C
KN
T
M
K
F
A
L
FTS
G
V
A
L
T
L
S
F
-------
V
F
M
Y
A
KCENEPFAGVSESYNGTGELGNLIAPCNANCNCSR
S
Y
YYPVCG-D
G
V
Q
Y
F
S
P
C
F
AGCSNPVAHRK
P
K
V
Y
Y
N
C
S
CIERKTEITS
T
A
E
TFGFEAKAGKC
E
T
H
C
A
K
L
P
I
F
L
C
I
F
F
I
V
I
I
F
T
F
MAGT
P
I
T
V
S
I
L
R
C
V
N
H
R
Q
R
S
L
A
L
G
I
Q
F
M
V
L
R
L
L
GTIPG
P
I
I
F
G
F
T
ID
S
T
C
I
L
W
DINDCGIK
G
A
C
W
I
YDN
I
K
M
A
H
M
L
V
A
I
S
V
T
C
K
V
I
T
M
F
FN
G
F
A
I
F
L
YKPPPSATD
V
S
FHKEN
A
V
V
T
N
V
L
A
E
Q
D
L
N
K
I
VKEG
19
Fugue
82.73
13%
-63
- C3 -
3N6R
1
?
A:
[2-681]
-------
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
---
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
------
G
A
Q
A
V
H
P
G
--------
Y
G
F
L
SEN
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
-
G
D
-
K
-
I
T
S
K
K
I
A
Q
E
--------
A
N
V
S
T
V
P
G
V
T
-------
Q
P
R
H
I
E
I
Q
---
V
L
C
D
S
---
H
G
N
G
I
Y
L
G
E
R
E
C
S
-------------
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
----
V
G
Y
A
-
S
A
G
T
V
E
F
I
V
D
G
Q
K
N
F
Y
F
L
E
M
-
N
T
R
L
Q
V
E
H
P
-
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
-
S
I
T
Q
-
G
D
V
K
L
----
T
G
----
W
A
I
E
N
R
L
Y
A
------
E
-
D
P
-
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
P
-------
P
A
E
A
A
V
R
N
D
T
-------
G
V
Y
E
G
G
E
I
S
M
Y
---------
Y
D
P
M
I
A
K
L
C
--------
T
W
A
P
T
R
A
A
A
I
E
A
M
R
I
A
------------
L
D
-
S
F
E
V
E
G
-
I
---
G
H
N
L
P
F
L
S
A
V
M
D
H
---
P
K
F
-----
I
S
G
D
M
T
T
A
F
I
A
-
E
E
Y
P
E
G
F
E
G
V
N
L
P
E
T
D
L
R
R
V
A
A
A
A
A
A
-------
M
H
R
V
A
E
I
R
R
T
R
V
S
G
R
M
D
N
--
H
E
R
R
V
G
T
E
W
V
V
T
L
Q
G
A
D
F
P
V
T
I
A
A
D
H
D
G
-
S
T
V
S
F
D
D
G
S
S
M
R
V
T
S
D
W
T
P
G
D
Q
L
A
N
L
M
V
D
G
A
P
L
V
L
K
V
G
K
I
S
G
G
--------------------------
F
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
A
E
L
A
R
L
M
P
E
K
L
P
P
D
T
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
-------
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
---------------------
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
A
------
V
D
D
V
I
M
E
F
E
29
HHSearch
60.33
16%
-91
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[37-329]
------------------------------------------------------------------------------------------------------------------------
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
-
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
---
L
G
A
A
L
F
W
P
A
A
E
I
------------------------------
M
N
-
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
----
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
-
M
L
-
T
-
K
F
P
A
L
-
Q
S
D
N
H
-
S
D
-----------------------------
A
K
Q
G
S
F
S
A
S
-
L
S
R
L
A
R
I
R
H
W
R
W
A
V
--------
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
------------
L
I
-
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
-
C
F
-----
F
I
G
R
F
T
G
T
W
L
I
-
S
R
F
A
--
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
-------
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
V
M
T
I
-
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
56.22
7%
-67
- C4 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
--------------------------------------------------------------------------------------------------------------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
-
R
L
-
R
-
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
E
Q
G
F
S
R
G
D
L
G
F
A
L
---
S
G
I
S
I
---
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
V
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
----
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
-------------------------
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
-
F
A
-
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
-------
Y
K
N
D
T
A
K
---------------------
Q
I
F
-
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
--------
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
------------
S
P
-
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
-
A
G
-----
I
P
G
T
L
L
C
G
W
M
S
-
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
NPAGN
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
-
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
49.83
16%
-88
- C4 -
2GFP
-
EMRD_ECOLI
A:
[22-270]
---------------------------------------------------------------------------------------------------------------------------
M
A
Q
T
I
Y
I
P
A
I
A
D
M
-
A
R
-
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
---
L
A
T
L
V
A
V
T
T
S
---------------------------------
S
-
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
----
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
--------------------------
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
-
A
R
W
M
P
E
T
R
P
V
D
A
-
P
-
R
-----------------------------------
T
R
L
L
T
S
-
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
--------
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
------------
S
G
-
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
-
A
A
-----
F
F
G
A
W
F
A
G
R
P
N
-
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
-------
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
-
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
47.75
8%
-109
- C4 -
1PW4
-
GLPT_ECOLI
A:
[28-317]
---------------------------------------------------------------------------------------------------------
W
Q
I
---
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
--
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
---
A
V
M
L
F
M
G
F
V
P
W
A
T
-----------------------------
S
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
----
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
-------------------------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
-
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
-------
K
N
D
-----------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
--------
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
------------
S
P
-
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
-
A
G
-----
I
P
G
T
L
L
C
G
W
M
S
-
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
-------
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
47.36
19%
-132
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[36-178]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
D
I
L
------------
L
P
-
Q
F
Q
Q
A
--
F
---
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
-
G
Y
-----
F
I
I
P
I
P
A
G
I
L
M
-
K
K
L
--
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
-------
P
A
A
E
I
-----------------------------------------------------------------------------------------------------
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
-
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
32
HHSearch
47.11
14%
-64
- C4 -
2CFQ
-
LACY_ECOLI
A:
[23-302]
-----------------------------------------------------------------------------------------------------------------------------
M
G
A
Y
F
P
F
F
P
I
W
-
L
H
-
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
---
A
P
F
F
I
F
I
F
G
P
---------------------------------
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
FCFN
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
I
---------------------------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
-
F
F
-
A
K
T
D
A
P
S
S
A
T
V
A
N
-
A
V
--------------------------
G
-
A
N
H
S
A
F
S
L
K
L
-
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
--------
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
------------
F
A
-
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
-
L
N
-----
A
S
I
M
F
F
A
P
L
I
I
-
N
R
I
G
--
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
-------
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
-
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
46.38
17%
-114
- C4 -
3WDO
-
?
A:
[27-179]
------------------------------------------------------------------------------------------------------------------------------
F
M
V
L
P
V
L
T
T
Y
G
M
A
-
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
---
A
G
S
V
I
A
A
L
S
D
---------------------------------
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
------
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
--------------------------
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
-
I
W
-
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
-------
V
K
G
S
F
S
K
V
L
A
-------
E
P
R
L
L
K
L
N
F
G
I
M
C
L
-
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
--------
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
------------
A
T
-
M
L
I
A
F
G
-
S
---
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
-----
F
C
V
G
L
I
V
V
A
E
I
-
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
-------
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
-
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-----------------------------------------------------------------------------------------------------------------------
33
HHSearch
43.62
10%
-120
* C4 *
3WDO
-
?
A:
[12-159]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
--------
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
------------
L
T
-
T
Y
G
M
A
L
-
Q
---
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
-
T
Q
-----
A
V
F
Q
I
P
F
G
L
L
S
-
D
R
I
--
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
A
A
-------
L
S
--------------------------------------------------------------------------------------------------------
D
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
--
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
-
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
12
PsiBlast_PDB
43.18
24%
-63
- C3 -
4XPB
4
?
A:
[96-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
A
F
Y
V
G
F
Y
Y
N
V
I
I
A
W
S
L
R
F
F
F
-
A
S
-
F
T
N
S
L
P
W
T
S
C
N
N
I
W
N
T
PNCRPFE
S
Q
G
F
Q
S
A
A
S
E
Y
F
N
RYIL
E
L
N
R
S
E
G
I
H
D
L
G
A
I
-
K
W
D
M
A
L
C
L
L
I
V
Y
L
I
C
Y
F
S
L
WKG
I
S
T
S
G
K
V
V
W
F
T
A
L
F
P
Y
A
V
L
L
I
L
L
I
R
G
L
T
L
P
G
S
F
L
G
I
Q
-
Y
---
Y
L
T
P
N
F
S
A
I
Y
K
A
E
V
W
V
D
A
A
T
Q
V
F
F
S
L
G
P
G
F
G
V
L
L
A
Y
A
S
Y
N
K
Y
H
N
N
V
Y
K
D
A
L
L
T
S
F
I
N
S
A
T
S
F
-------
I
A
G
F
V
I
F
S
V
L
G
Y
M
A
H
T
L
G
V
R
I
E
D
V
A
T
E
G
P
G
L
V
F
V
V
Y
P
A
A
I
A
T
M
P
A
S
T
F
-
W
A
L
I
F
F
M
M
L
A
T
L
G
L
D
S
S
F
G
G
M
E
A
I
I
T
A
L
S
D
E
F
P
K
I
K
R
N
R
E
L
F
V
A
G
L
F
S
L
Y
F
V
V
G
L
A
S
C
T
Q
G
G
F
Y
F
F
H
L
L
D
R
Y
A
A
G
Y
S
I
L
V
A
V
F
F
E
A
I
A
V
S
W
I
Y
G
T
N
R
F
S
E
D
I
R
D
M
I
G
F
P
P
G
R
Y
W
Q
V
C
W
R
F
V
A
P
I
F
L
L
F
I
T
V
Y
G
L
I
G
Y
E
P
L
T
Y
A
D
Y
V
Y
P
S
W
A
N
A
L
G
W
C
I
A
G
S
S
V
V
M
I
P
A
V
A
I
F
K
L
L
S
T
P
G
S
L
R
Q
R
F
T
I
L
T
T
P
W
R
D
-------------
13
PsiBlast_PDB
42.15
24%
-54
- C3 -
4XPF
5
?
A:
[91-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
A
F
Y
V
G
F
Y
Y
N
V
I
I
A
W
S
L
R
F
F
F
-
A
S
-
F
T
N
S
L
P
W
T
S
C
N
N
I
W
N
T
PNCRPFE
S
Q
G
F
Q
S
A
A
S
E
Y
F
N
RYIL
E
L
N
R
S
E
G
I
H
D
L
G
A
I
-
K
W
D
M
A
L
C
L
L
I
V
Y
L
I
C
Y
F
S
LWKG
I
S
T
S
G
K
V
V
W
F
T
A
L
F
P
Y
A
V
L
L
I
L
L
I
R
G
L
T
L
P
G
S
F
L
G
I
Q
-
Y
---
Y
L
T
P
N
F
S
A
I
Y
K
A
E
V
W
V
D
A
A
T
Q
V
F
F
S
L
G
P
G
F
G
V
L
L
A
Y
A
S
Y
N
K
Y
H
N
N
V
Y
K
D
A
L
L
T
S
F
I
N
S
A
T
S
F
-------
I
A
G
F
V
I
F
S
V
L
G
Y
M
A
H
T
L
G
V
R
I
E
D
V
A
T
E
G
P
G
L
V
F
V
V
Y
P
A
A
I
A
T
M
P
A
S
T
F
-
W
A
L
I
F
F
M
M
L
A
T
L
G
L
D
S
S
F
G
G
M
E
A
I
I
T
A
L
S
D
E
F
P
K
I
K
R
N
R
E
L
F
V
A
G
L
F
S
L
Y
F
V
V
G
L
A
S
C
T
Q
G
G
F
Y
F
F
H
L
L
D
R
Y
A
A
G
Y
S
I
L
V
A
V
F
F
E
A
I
A
V
S
W
I
Y
G
T
N
R
F
S
E
D
I
R
D
M
I
G
F
P
P
G
R
Y
W
Q
V
C
W
R
F
V
A
P
I
F
L
L
F
I
T
V
Y
G
L
I
G
Y
E
P
L
T
Y
A
D
Y
V
Y
P
S
W
A
N
A
L
G
W
C
I
A
G
S
S
V
V
M
I
P
A
V
A
I
F
K
L
L
S
T
P
G
S
L
R
Q
R
F
T
I
L
T
T
P
W
R
D
-------------
35
HHSearch
41.26
12%
-139
- C4 -
2GFP
-
EMRD_ECOLI
A:
[22-158]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Q
T
I
Y
I
P
A
------------
I
A
-
D
M
A
R
D
--
L
---
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
-
T
Y
-----
G
V
S
Q
L
F
Y
G
P
I
S
-
D
R
V
--
G
R
R
P
V
I
L
V
G
M
S
I
F
M
L
A
T
L
V
A
V
-------
T
T
--------------------------------------------------------------------------------------------------------
S
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
-
S
P
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
36
HHSearch
41.11
11%
-88
- C4 -
2CFQ
-
LACY_ECOLI
A:
[257-393]
-------------------------------------------------------------------------------------------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
---
V
R
I
I
G
S
S
F
A
T
---------------------------------
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
----
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
--------------------------
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
-
V
F
-
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
-------
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
39.62
12%
-51
- C4 -
1PW4
-
GLPT_ECOLI
A:
[275-410]
-----------------------------------------------------------------------------------------------------------------------------------
W
S
P
T
Y
-
L
K
E
V
-
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
--
A
-----------------------------
G
N
-
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
----
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
-
I
G
G
S
-
I
L
A
V
I
----
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
36.92
28%
28
- C5 -
3WPZ
-
?
A:
[17-68]
----------
A
Y
A
P
E
D
D
F
T
A
K
W
T
R
A
D
A
R
Q
L
Q
R
M
S
D
P
T
A
P
S
R
E
N
S
M
P
A
S
V
T
M
P
T
V
P
Q
D
F
P
D
M
S
N
E
Q
V
W
V
W
D
T
W
P
L
T
D
E
D
A
N
Q
Y
S
V
N
G
W
E
I
I
F
S
L
V
A
D
R
N
L
G
F
D
D
R
H
V
F
A
---
K
I
G
Y
F
Y
R
P
A
G
V
P
A
A
E
R
P
E
N
G
G
W
T
Y
G
-
G
L
-
V
-
F
K
E
G
V
T
G
Q
I
F
E
D
Q
S
F
S
H
Q
T
Q
W
T
G
S
A
R
V
S
K
N
G
E
I
K
L
F
F
T
D
V
A
F
---
Y
R
N
S
D
---
G
T
N
I
K
P
Y
D
P
R
I
A
L
S
V
G
K
V
K
A
N
K
K
G
V
T
L
T
G
F
N
K
V
T
D
L
L
Q
A
D
G
T
Y
Y
Q
T
G
A
Q
N
E
F
F
N
F
R
D
P
F
T
F
----
E
D
P
A
H
P
G
E
T
F
M
V
F
E
G
N
S
A
M
Q
R
E
T
A
T
-
C
N
E
A
D
L
G
Y
R
-
Q
G
D
P
Y
A
E
T
V
D
D
V
N
A
S
G
A
T
Y
Q
I
G
N
-
V
G
L
A
-
K
A
K
N
K
----
Q
L
T
E
W
E
F
L
P
P
I
L
S
A
N
C
V
T
D
Q
T
E
-
R
P
-
Q
I
Y
F
K
D
G
K
S
Y
L
F
T
I
S
H
-------
R
G
T
F
A
A
G
L
D
G
-------
P
E
G
V
Y
G
F
V
G
D
G
I
R
S
-
D
Y
Q
P
L
N
G
G
S
G
L
A
L
G
--------
N
P
T
N
L
N
F
L
G
G
Q
P
F
A
P
D
------------
P
N
-
Q
H
P
G
H
F
-
Q
---
A
Y
S
H
Y
V
M
P
G
G
L
V
Q
S
Y
I
D
T
I
-----
G
T
H
D
D
F
V
R
G
G
T
-
L
A
P
T
V
K
M
D
I
G
V
G
G
D
S
T
K
T
A
V
D
Y
S
Y
G
S
-------
E
G
L
G
G
W
A
D
I
P
A
N
K
H
L
F
T
N
G
K
F
G
V
A
V
S
D
E
A
A
Q
K
I
R
K
I
L
G
S
K
F
D
D
Y
L
D
G
K
-
P
V
S
A
T
V
R
A
L
I
E
K
L
L
A
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
36.55
28%
50
- C5 -
3VSR
-
?
A:
[53-104]
----------
A
Y
A
P
E
D
D
F
T
A
K
W
T
R
A
D
A
R
Q
L
Q
R
M
S
D
P
T
A
P
S
R
E
N
S
M
P
A
S
V
T
M
P
T
V
P
Q
D
F
P
D
M
S
N
E
Q
V
W
V
W
D
T
W
P
L
T
D
E
D
A
N
Q
Y
S
V
N
G
W
E
I
I
F
S
L
V
A
D
R
N
L
G
F
D
D
R
H
V
F
A
---
K
I
G
Y
F
Y
R
P
A
G
V
P
A
A
E
R
P
E
N
G
G
W
T
Y
G
-
G
L
-
V
-
F
K
E
G
V
T
G
Q
I
F
E
D
Q
S
F
S
H
Q
T
Q
W
S
G
S
A
R
V
S
K
N
G
E
I
K
L
F
F
T
D
V
A
F
---
Y
R
N
S
D
---
G
T
N
I
K
P
Y
D
P
R
I
A
L
S
V
G
K
V
K
A
N
K
K
G
V
T
L
T
G
F
N
K
V
T
D
L
L
Q
A
D
G
T
Y
Y
Q
T
G
A
Q
N
E
F
F
N
F
R
D
P
F
T
F
----
E
D
P
A
H
P
G
E
T
F
M
V
F
E
G
N
S
A
M
Q
R
E
T
A
T
-
C
N
E
A
D
L
G
Y
R
-
Q
G
D
P
Y
A
E
T
V
D
D
V
N
A
S
G
A
T
Y
Q
I
G
N
-
V
G
L
A
-
K
A
K
N
K
----
Q
L
T
E
W
E
F
L
P
P
I
L
S
A
N
C
V
T
D
Q
T
E
-
R
P
-
Q
I
Y
F
K
D
G
K
S
Y
L
F
T
I
S
H
-------
R
G
T
F
A
A
G
L
D
G
-------
P
E
G
V
Y
G
F
V
G
D
G
I
R
S
-
D
Y
Q
P
L
N
G
G
S
G
L
A
L
G
--------
N
P
T
N
L
N
F
L
G
G
Q
P
F
A
P
D
------------
F
N
-
Q
H
P
G
H
F
-
Q
---
A
Y
S
H
Y
V
M
P
G
G
L
V
Q
S
F
I
D
T
I
-----
G
T
H
D
D
F
V
R
G
G
T
-
L
A
P
T
V
K
M
D
I
G
V
G
G
D
P
T
K
T
A
V
D
Y
S
Y
G
S
-------
E
G
L
G
G
W
A
D
I
P
A
N
K
H
L
F
T
N
G
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
36.45
35%
28
- C3 -
2ERW
-
?
A:
[4-50]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
C
A
C
F
R
-
N
Y
V
P
V
C
G
S
D
G
K
T
Y
G
N
P
C
M
L
N
C
A
A
Q
T
K
V
P
G
L
K
L
V
H
E
G
R
C
Q
R
S
N
V
E
Q
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
36.41
28%
25
- C5 -
3WPV
-
?
A:
[17-68]
----------
A
Y
A
P
E
D
D
F
T
A
K
W
T
R
A
D
A
R
Q
L
Q
R
M
S
D
P
T
A
P
S
R
E
N
S
M
P
A
S
V
T
M
P
T
V
P
Q
D
F
P
D
M
S
N
E
Q
V
W
V
W
D
T
W
P
L
T
D
E
D
A
N
Q
Y
S
V
N
G
W
E
I
I
F
S
L
V
A
D
R
N
L
G
F
D
D
R
H
V
F
A
---
K
I
G
Y
F
Y
R
P
A
G
V
P
A
A
E
R
P
E
N
G
G
W
T
Y
G
-
G
L
-
V
-
F
K
E
G
V
T
G
Q
I
F
E
D
Q
S
F
S
H
Q
T
Q
W
S
G
S
A
R
V
S
K
N
G
E
I
K
L
F
F
T
D
V
A
F
---
Y
R
N
S
D
---
G
T
N
I
K
P
Y
D
P
R
I
A
L
S
V
G
K
V
K
A
N
K
K
G
V
T
L
T
G
F
N
K
V
T
D
L
L
Q
A
D
G
T
Y
Y
Q
T
G
A
Q
N
E
F
F
N
F
R
D
P
F
T
F
----
E
D
P
A
H
P
G
E
T
F
M
V
F
E
G
N
S
A
M
Q
R
E
T
A
T
-
C
N
E
A
D
L
G
Y
R
-
Q
G
D
P
Y
A
E
T
V
D
D
V
N
A
S
G
A
T
Y
Q
I
G
N
-
V
G
L
A
-
K
A
K
N
K
----
Q
L
T
E
W
E
F
L
P
P
I
L
S
A
N
C
V
T
D
Q
T
E
-
R
P
-
Q
I
Y
F
K
D
G
K
S
Y
L
F
T
I
S
H
-------
R
G
T
F
A
A
G
L
D
G
-------
P
E
G
V
Y
G
F
V
G
D
G
I
R
S
-
D
Y
Q
P
L
N
G
G
S
G
L
A
L
G
--------
N
P
T
N
L
N
F
L
G
G
Q
P
F
A
P
D
------------
V
N
-
Q
H
P
G
H
F
-
Q
---
A
Y
S
H
Y
V
M
P
G
G
L
V
Q
S
Y
I
D
T
I
-----
G
T
H
D
D
F
V
R
G
G
T
-
L
A
P
T
V
K
M
D
I
G
V
G
G
D
S
T
K
T
A
V
D
Y
S
Y
G
S
-------
E
G
L
G
G
W
A
D
I
P
A
N
K
H
L
F
T
N
G
K
F
G
V
A
V
S
D
E
A
A
Q
K
I
R
K
I
L
G
S
K
F
D
D
Y
L
D
G
K
-
P
V
S
A
T
V
R
A
L
I
E
K
L
L
A
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
36.20
28%
29
- C5 -
3WPY
-
?
A:
[17-68]
----------
A
Y
A
P
E
D
D
F
T
A
K
W
T
R
A
D
A
R
Q
L
Q
R
M
S
D
P
T
A
P
S
R
E
N
S
M
P
A
S
V
T
M
P
T
V
P
Q
D
F
P
D
M
S
N
E
Q
V
W
V
W
D
T
W
P
L
T
D
E
D
A
N
Q
Y
S
V
N
G
W
E
I
I
F
S
L
V
A
D
R
N
L
G
F
D
D
R
H
V
F
A
---
K
I
G
Y
F
Y
R
P
A
G
V
P
A
A
E
R
P
E
N
G
G
W
T
Y
G
-
G
L
-
V
-
F
K
E
G
V
T
G
Q
I
F
E
D
Q
S
F
S
H
Q
T
Q
W
T
G
S
A
R
V
S
K
N
G
E
I
K
L
F
F
T
D
V
A
F
---
Y
R
N
S
D
---
G
T
N
I
K
P
Y
D
P
R
I
A
L
S
V
G
K
V
K
A
N
K
K
G
V
T
L
T
G
F
N
K
V
T
D
L
L
Q
A
D
G
T
Y
Y
Q
T
G
A
Q
N
E
F
F
N
F
R
D
P
F
T
F
----
E
D
P
A
H
P
G
E
T
F
M
V
F
E
G
N
S
A
M
Q
R
E
T
A
T
-
C
N
E
A
D
L
G
Y
R
-
Q
G
D
P
Y
A
E
T
V
D
D
V
N
A
S
G
A
T
Y
Q
I
G
N
-
V
G
L
A
-
K
A
K
N
K
----
Q
L
T
E
W
E
F
L
P
P
I
L
S
A
N
C
V
T
D
Q
T
E
-
R
P
-
Q
I
Y
F
K
D
G
K
S
Y
L
F
T
I
S
H
-------
R
G
T
F
A
A
G
L
D
G
-------
P
E
G
V
Y
G
F
V
G
D
G
I
R
S
-
D
Y
Q
P
L
N
G
G
S
G
L
A
L
G
--------
N
P
T
N
L
N
F
L
G
G
Q
P
F
A
P
D
------------
V
N
-
Q
H
P
G
H
F
-
Q
---
A
Y
S
H
Y
V
M
P
G
G
L
V
Q
S
F
I
D
T
I
-----
G
T
H
D
D
F
V
R
G
G
T
-
L
A
P
T
V
K
M
D
I
G
V
G
G
D
S
T
K
T
A
V
D
Y
S
Y
G
S
-------
E
G
L
G
G
W
A
D
I
P
A
N
K
H
L
F
T
N
G
K
F
G
V
A
V
S
D
E
A
A
Q
K
I
R
K
I
L
G
S
K
F
D
D
Y
L
D
G
K
-
P
V
S
A
T
V
R
A
L
I
E
K
L
L
A
Q
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
36.04
28%
39
* C5 *
3VSS
2
?
A:
[17-68]
----------
A
Y
A
P
E
D
D
F
T
A
K
W
T
R
A
D
A
R
Q
L
Q
R
M
S
D
P
T
A
P
S
R
E
N
S
M
P
A
S
V
T
M
P
T
V
P
Q
D
F
P
D
M
S
N
E
Q
V
W
V
W
D
T
W
P
L
T
D
E
D
A
N
Q
Y
S
V
N
G
W
E
I
I
F
S
L
V
A
D
R
N
L
G
F
D
D
R
H
V
F
A
---
K
I
G
Y
F
Y
R
P
A
G
V
P
A
A
E
R
P
E
N
G
G
W
T
Y
G
-
G
L
-
V
-
F
K
E
G
V
T
G
Q
I
F
E
D
Q
S
F
S
H
Q
T
Q
W
S
G
S
A
R
V
S
K
N
G
E
I
K
L
F
F
T
D
V
A
F
---
Y
R
N
S
D
---
G
T
N
I
K
P
Y
D
P
R
I
A
L
S
V
G
K
V
K
A
N
K
K
G
V
T
L
T
G
F
N
K
V
T
D
L
L
Q
A
D
G
T
Y
Y
Q
T
G
A
Q
N
E
F
F
N
F
R
D
P
F
T
F
----
E
D
P
A
H
P
G
E
T
F
M
V
F
E
G
N
S
A
M
Q
R
E
T
A
T
-
C
N
E
A
D
L
G
Y
R
-
Q
G
D
P
Y
A
E
T
V
D
D
V
N
A
S
G
A
T
Y
Q
I
G
N
-
V
G
L
A
-
K
A
K
N
K
----
Q
L
T
E
W
E
F
L
P
P
I
L
S
A
N
C
V
T
D
Q
T
E
-
R
P
-
Q
I
Y
F
K
D
G
K
S
Y
L
F
T
I
S
H
-------
R
G
T
F
A
A
G
L
D
G
-------
P
E
G
V
Y
G
F
V
G
D
G
I
R
S
-
D
Y
Q
P
L
N
G
G
S
G
L
A
L
G
--------
N
P
T
N
L
N
F
L
G
G
Q
P
F
A
P
D
------------
F
N
-
Q
H
P
G
H
F
-
Q
---
A
Y
S
H
Y
V
M
P
G
G
L
V
Q
S
F
I
D
T
I
-----
G
T
H
D
D
F
V
R
G
G
T
-
L
A
P
T
V
K
M
D
I
G
V
G
G
D
P
T
K
T
A
V
D
Y
S
Y
G
S
-------
E
G
L
G
G
W
A
D
I
P
A
N
K
H
L
F
T
N
G
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------