@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO5A1_HUMAN: (2015-12-12 )
MDEGTGLQPGAGEQLEAPATAEAVQERCEPETLRSKSLPVLSSASCRPSLSPTSGDANPAFGCVDSSGHQELKQGPNPLAPSPSAPSTSAGLGDCNHRVDLSKTFSVSSALAMLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQIQELNASAPNDGLCQGGNSTATLEPPACPKDSGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRQREFPLSTVSERVGHPDNARTRSCPAFSTQGEFHEETGLQKGIQCAAQTYPGPFPEAISSSADPGLEESPAALEPPS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140....-...150...-....-160------........170-----------------.......180.......190...--------....200--.......--.210.......-----220.......230.......240.......250.......260.......270....----...280.......290.......300..-.....310.-......320.......330.---..---....340..--....--.350.......360.......370.......380.......390.......400.......410.......420..-.....430.....-----..440.......450.......460-.---.--.....470.......480.......490.......500.......510.......520.......530.......540.......550.....-..560........570.......580....-----....590.......600.......610.......620.......630.......640.......650.....----..660.......670.......680.......690.......700.......710.......720.......730---.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDEGTGLQPGAGEQLEAP
A
T
A
E
A
V
Q
E
RCEPETLRSKSLPVLSSASCRPSLSPTSGDANPA
F
G
CVDSSG
H
Q
E
L
K
QGPNPLAPSPSAPSTSAGLGDCNHRVDL
S
K
TF
S
V
S
S
A
L
A
M
L
Q
ER
R
C
L
Y
V
V
L
TDS
R
C
F
L
V
C
M
C
F
L
T
F
I
Q
A
L
M
V
S
-
G
Y
L
S
S
V
I
T
T
-
I
E
R
R
-YS-------LKSSES
G
L
L
V
S
-----------------
C
F
DIGN
L
V
V
V
V
F
V
S
Y
FGGRGR
R
P
--------
L
W
L
A
V
G
---
G
L
L
I
A
F
G
--
A
A
L
F
A
L
P
H
FIS-----PP
Y
Q
I
Q
ELNASAPNDGLCQGGNSTATLEPPACPKDSGGNN
H
W
V
Y
V
A
L
F
I
C
A
Q
I
L
IGM----GST
P
I
Y
T
LG
P
T
YLDDNVKKENSS
L
Y
L
A
I
-
M
Y
V
M
GA
L
G
P
-
A
V
G
Y
L
L
G
G
L
L
I
G
F
Y
VDPRNP---VH---LDQNDP
R
F
I
--
G
N
W
W
--
S
G
F
L
L
C
A
I
A
M
F
L
V
I
F
P
M
FTFPKKLPP
R
H
K
K
K
K
KKKFSVDAVSD
D
D
V
L
KEKSN
N
S
E
Q
A
D
K
K
V
S
SMGFG
K
D
V
R
D
L
P
R
A
-
A
V
R
I
LSN
M
T
F
L
F
V
-----
S
L
SYTA
E
S
A
I
V
T
A
F
I
T
F
I
P
K
F
I
E
S
Q-F---G--IPASNA
S
I
Y
T
G
V
I
I
VPSAG
V
G
I
V
L
G
G
Y
I
I
K
K
L
KLGARESA
K
L
A
M
I
C
S
G
V
S
L
L
C
F
S
T
L
F
I
VGCESINLGGINIPYTTGPSLTMPHRNLTGSCNV-NCG
C
-
K
I
H
E
YEPVCGSDG
I
T
Y
F
N
P
C
-
L
A
G
C-----VNSGNL
S
T
GIRNY
T
E
C
T
C
VQSRQVITPPTVGQRS
Q
L
R
V
V
I
V
K
T
YLNEN
G
Y
A
VS
G
K
C
K
R
T
C
N
T
L
I
P
F
L
V
F
L
F
I
----
V
T
F
I
T
A
CAQP
S
A
I
I
V
T
L
RSVEDEER
P
F
A
L
G
M
Q
F
V
L
L
R
T
L
A
YIPTP
I
Y
F
G
A
V
I
D
T
T
C
M
L
W
Q
Q
ECGVQGS
C
W
E
YNV
T
---
S
F
R
F
V
Y
F
G
L
A
A
G
L
K
F
V
G
F
I
F
I
F
L
A
W
Y
S
I
K
Y
K
E
D
G
L
Q
R
R
R
Q
REF
P
L
S
T
V
S
E
RVGHPDNARTRSCPAFSTQGE
F
H
E
E
T
G
L
Q
K
G
I
Q
C
A
AQTYPGP
F
P
E
A
ISSSADPGLEESPAALEPPS
27
Fugue
81.60
17%
-94
- C1 -
3WKX
1
HYBA1_BIFL2
A:
[1-659]
--------------
M
N
V
T
I
T
S
P
F
W
K
R
R
R
D
--
Q
I
V
E
S
V
I
P
Y
Q
W
G
V
M
N
D
E
---------------
I
D
T
T
V
P
D
D
P
A
G
N
Q
L
A
D
S
K
S
H
A
V
A
N
L
K
V
A
A
G
E
L
D
D
E
F
H
-
G
M
V
F
Q
D
S
D
V
Y
K
W
L
E
E
A
A
Y
A
L
A
Y
H
P
D
P
E
L
K
A
L
C
D
R
T
V
D
L
I
A
R
A
Q
Q
S
D
G
Y
L
D
T
P
Y
Q
I
-
K
S
G
V
-
W
A
DRPRFSL
I
Q
Q
S
H
E
M
Y
V
M
G
H
Y
I
E
A
A
V
A
Y
H
Q
V
TGN
E
Q
A
L
E
V
A
K
K
M
A
D
C
L
D
A
N
F
G
P
E
E
G
K
I
HGADGHPE
I
E
L
A
L
A
---
K
L
Y
E
E
T
G
E
K
R
Y
L
T
L
S
Q
Y
L
I
D
V
RGQD
P
Q
F
Y
A
K
Q
L
K
A
M
N
G
D
N
I
F
H
G
F
Y
K
P
T
Y
F
Q
A
A
E
P
V
R
D
Q
Q
T
A
D
G
H
A
V
R
V
G
Y
L
C
T
G
V
A
H
V
G
R
----
L
L
------
G
D
Q
G
L
I
D
T
A
K
R
F
W
K
N
I
V
T
R
R
-
M
Y
V
T
G
A
I
G
S
-
T
---
H
V
G
E
S
F
T
Y
D
Y
D
L
P
N
D
T
---
M
Y
---------------------
G
E
T
C
A
S
V
A
M
S
M
F
A
Q
Q
M
L
D
L
E
P
K
----------------
G
E
Y
A
D
V
L
E
K
E
L
F
N
G
S
---------------------
I
-
A
G
I
S
L
D
G
K
Q
Y
Y
Y
V
-----
N
A
L
E
T
T
P
D
G
L
D
N
P
D
R
H
H
V
L
S
H
R
V
D
W
-
F
---
G
--
C
A
C
C
----------------------------------
P
A
N
I
A
R
L
I
A
S
V
D
R
Y
I
Y
T
E
R
------------------
D
G
G
K
T
V
L
S
H
Q
F
I
A
N
T
A
E
F
-
A
S
G
L
-
T
V
E
Q
R
S
N
F
P
W
D
G
-------------------------------------
H
V
E
Y
T
V
S
L
P
A
S
A
T
D
S
S
V
R
F
G
L
R
I
P
G
W
S
R
G
S
Y
T
L
T
V
N
G
K
P
A
V
G
S
L
E
D
G
F
V
Y
L
V
V
N
AG
D
T
L
E
I
A
L
E
L
D
M
S
V
K
F
V
R
A
N
S
-----
R
V
R
S
D
A
G
Q
V
A
V
M
R
G
------
P
L
V
Y
C
A
E
Q
V
D
N
----------
P
G
D
L
W
N
Y
R
L
A
D
GV
T
G
A
D
A
A
V
A
F
Q
A
D
L
-
L
G
G
V
D
T
V
D
L
P
A
V
R
E
H
A
D
E
D
D
A
P
L
Y
V
D
A
D
E
P
------
R
A
G
E
P
A
T
L
R
L
V
P
Y
Y
S
W
A
N
R
-----
E
I
G
E
M
R
V
F
Q
R
R
A
------------------------------
32
HHSearch
55.26
15%
-97
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------
A
N
-
N
L
N
D
I
L
L
P
Q
-
F
Q
Q
A
-
F
T
-------
L
T
N
F
Q
A
G
L
I
Q
S
-----------------
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
--------
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
--
A
A
L
F
W
P
A
A
E
------------------------------------------------
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
----
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
--
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
-
K
-
F
P
A
L
Q
S
D
N
H
S
-
D
-
A
-------------------------------
K
Q
G
S
F
S
A
S
-
L
S
R
L
A
R
I
R
H
W
R
W
A
-----
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
--
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
-
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
--
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
-
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
-
D
A
A
G
-----
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
49.85
11%
-109
- C2 -
1PW4
-
GLPT_ECOLI
A:
[46-316]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
N
F
A
L
A
M
P
Y
-
L
V
-
E
-
Q
G
-------
F
S
R
G
D
L
G
F
A
L
S
-----------------
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
--------
V
F
L
P
A
G
---
L
I
L
A
A
A
V
--
M
L
F
M
G
F
V
P
W
A
-----------------------------------------------
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
-------------------------
N
D
W
H
--
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
--------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
-----
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
--
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
-
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
-
K
K
A
A
-
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
-
A
I
V
G
-----
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
49.65
9%
-81
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
--------------------------------------------------------------------------------------------------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
-
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
-
K
N
F
A
L
A
M
P
Y
-
L
-
V
E
-
Q
G
-------
F
S
R
G
D
L
G
F
A
L
S
-----------------
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
--------
V
F
L
P
A
G
---
L
I
L
A
A
A
V
--
M
L
F
M
G
F
V
P
W
A
T
-----
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
----
L
F
L
L
G
M
A
W
F
N
D
W
---------
H
A
A
L
Y
M
P
-
A
F
C
A
I
L
V
A
L
-
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
---
Y
K
---
N
D
T
A
K
Q
I
F
M
--
Q
Y
V
L
PN
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
-
M
T
L
V
T
I
A
T
I
V
Y
W
M
NPAGN
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
-
A
---
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
46.23
17%
-86
- C2 -
2GFP
-
EMRD_ECOLI
A:
[25-270]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
I
Y
I
P
A
I
A
D
-
M
A
R
D
-
L
N
-------
V
R
E
G
A
V
Q
S
V
M
G
-----------------
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
--------
P
V
I
L
V
G
---
M
S
I
F
M
L
A
--
T
L
V
A
V
T
T
S
---------------------------------------------------
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
--------------------------
N
W
R
--
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
---
P
R
------------------------------------
T
R
L
L
T
S
-
Y
K
T
L
F
G
N
S
G
F
N
C
Y
-----
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-
L
---
G
--
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
-
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
-
A
G
T
A
-
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
-
M
L
P
Q
-----
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
46.00
19%
-126
- C2 -
3WDO
-
?
A:
[30-179]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
-------
A
S
E
A
L
I
G
I
A
I
G
-----------------
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
--------
P
L
I
V
G
G
---
L
A
V
F
A
A
G
--
S
V
I
A
A
L
S
D
---------------------------------------------------
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
----
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
--------------------------
G
L
H
--
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
-
A
G
F
P
A
A
E
H
W
K
V
Y
L
-----
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
-
V
---
F
--
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
-
A
M
L
A
-
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
-
I
E
I
P
-----
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
40.14
15%
-114
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[36-178]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
--
F
---
T
--
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
-
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
--
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
---------------------------------------------------------------------------------------------------------------------------------
M
N
Y
T
L
F
L
V
G
L
F
I
----
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
-
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
---
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
36
HHSearch
39.66
13%
-98
- C2 -
1PW4
-
GLPT_ECOLI
A:
[279-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
L
K
E
V
-
K
H
-------
F
A
L
D
K
S
S
W
A
Y
F
-----------------
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
--------
N
R
G
A
T
G
---
V
F
F
M
T
L
V
--
T
I
A
T
I
V
Y
W
-
M
N
-----
P
----------------------------------------
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
----
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
--------------------------
G
W
D
--
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
39.56
41%
44
- C3 -
2ERW
-
?
A:
[6-51]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
--
F
R
N
Y
V
P
V
C
G
S
D
G
K
T
Y
G
N
P
C
-
M
L
N
C
-----
A
A
Q
T
K
V
P
-
G
L
K
L
V
H
E
G
R
C
Q
R
S
N
V
E
Q
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
39.48
13%
-76
- C2 -
2CFQ
-
LACY_ECOLI
A:
[26-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
P
F
F
P
I
-
W
L
H
D
I
N
H
-------
I
S
K
S
D
T
G
I
I
F
A
-----------------
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
--------
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
--
F
F
I
F
I
F
G
P
-------------------------------------------------
L
-
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
YLGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
I
---------------------------
N
N
Q
--
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
-
A
V
G
A
------------------------------
N
H
S
A
F
S
L
K
L
-
A
L
E
L
F
R
Q
P
K
L
W
F
L
-----
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
--
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
-
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
--
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
-
S
A
T
I
-
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
-
G
N
M
Y
-----
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
38.59
39%
53
- C3 -
2ERW
-
?
A:
[4-50]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
P
C
A
C
-
F
R
-
N
Y
V
P
V
C
G
S
D
G
K
T
Y
G
N
P
C
-
M
L
N
C
-----
A
A
Q
T
K
V
-
P
G
L
K
L
V
H
E
G
R
C
Q
R
S
N
V
E
Q
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
38.16
53%
191
- C3 -
1TGS
-
ISK1_PIG
I:
[1-36]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
P
Q
R
E
A
T
C
T
S
E
V
-
S
-
G
C
P
K
I
--
Y
N
P
V
C
G
T
D
G
I
T
Y
S
N
E
C
-
V
L
C
S
-----
E
N
K
K
R
Q
T
P
V
L
I
Q
K
S
G
P
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
35.52
47%
174
- C3 -
2F3C
-
?
I:
[5-34]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
A
C
-
P
R
-
V
L
H
R
V
C
G
S
D
G
N
T
Y
S
N
P
C
-
T
L
D
C
-----
A
K
H
E
G
K
P
D
L
V
Q
V
H
E
G
P
C
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
35.24
38%
104
- C3 -
2NU1
-
IOVO_MELOE
I:
[18-56]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
Y
R
P
L
C
G
S
D
N
K
T
Y
G
N
K
C
N
F
C
N
A
-----
V
V
E
S
N
G
T
L
T
L
S
H
F
G
K
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
34.17
44%
82
- C3 -
1TBR
-
THBI_RHOPR
R:
[60-101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
-
D
G
D
E
Y
K
P
V
C
G
S
D
D
I
T
Y
D
N
N
C
-
R
L
E
C
-----
A
S
I
S
S
-
S
P
G
V
E
L
K
H
E
G
P
C
R
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
33.56
50%
196
- C3 -
1LDT
-
LDTI_HIRME
L:
[11-46]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
-
I
A
R
C
NGVSI
K
S
E
G
S
C
P
T
G
I
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
33.40
47%
164
- C3 -
1CGJ
-
ISK1_HUMAN
I:
[7-41]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
C
Y
N
E
L
N
G
C
-
T
L
-
E
Y
R
P
V
C
G
T
D
G
D
T
Y
P
N
E
C
-
V
L
C
F
-----
E
N
R
K
R
Q
T
S
I
L
I
Q
K
S
G
P
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
33.11
44%
95
- C3 -
1TBQ
-
THBI_RHOPR
R:
[60-101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
-
D
G
D
E
Y
K
P
V
C
G
S
D
D
I
T
Y
D
N
N
C
-
R
L
E
C
-----
A
S
I
S
S
-
S
P
G
V
E
L
K
H
E
G
P
C
R
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
32.24
10%
-99
* C2 *
2CFQ
-
LACY_ECOLI
A:
[257-393]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
-----------------
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
--------
N
A
L
L
L
A
---
G
T
I
M
S
V
R
--
I
I
G
S
S
F
A
T
-------------------------------------------------
S
--
A
L
E
V
V
I
L
K
T
L
H
M
F
----
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
--------------------------
G
F
Q
--
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
32.05
52%
221
- C3 -
1LDT
-
LDTI_HIRME
L:
[3-31]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
C
A
C
-
P
K
-
I
L
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
-
I
A
R
C
-----
N
G
V
S
I
K
S
E
G
S
C
P
T
G
I
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------