@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UCP3_HUMAN: (2015-12-12 )
MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF
Atome Classification :
(20 SA)
---------------------------------------------------------------------------.........10.---.......------20........30........40..-----------------------------------...-...-50-....-....60........70........80........90.....---...100..-..----...110---....--....120-----.......130.....---..140.......150.......160.......170.......180.......190......--------.200.......---210.----......---------220.......230....----...240....-----...250----.-----.......260....----...270---......--..280.--------......290.------......300......--.310----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------MVGLKPSDVPPT---
M
A
V
K
F
LG------A
G
T
A
A
C
F
A
D
L
V
TFPLD
T
A
K
V
R
L
Q
I
-----------------------------------QGE-NQ
A
-
V
Q
-
T
A
R
L
-
V
Q
Y
R
G
V
L
G
T
I
L
T
M
V
RTEGPCSP
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
A
S
I
R
I
---G
L
Y
D
S
V
K
Q
-VY----TPKGA----DNS
S
--
L
T
T
R
I
L
A-----GCTT
G
A
M
A
V
TCAQPT---
D
V
V
K
V
R
F
Q
A
S
I
H
LGPSRSDRKYSG
T
M
D
A
Y
R
T
I
A
R
E
EG
V
R
G
L
W
K
G
T
L
P
N
I
M
R
N
A
I
V
N
C
A
E
V
V
--------
T
Y
D
I
L
K
E
K
L
L
D
---
Y
H
LL----TDNFP
C
---------
H
F
V
S
A
FGA
G
F
C
A
T
V
VAS----
P
V
D
V
V
K
T
RYM-----NSPPG-----Q-----YF
S
P
L
D
C
M
I
K
M
V
A
Q----EGP
T
A
----
F
YKGF
T
--
P
S
F
LRL--------GS
W
N
V
V
M
F
V
T
------
Y
E
Q
L
K
R
A
L
M
K
V
Q
M
L
R--ESPF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.73
73%
-67
- C3 -
2LCK
-
UCP2_MOUSE
A:
[13-309]
------------------------------------------------------------------------------------------
M
T
V
K
F
L
G
------
A
G
T
A
A
C
I
A
D
L
I
T
F
P
L
D
T
A
K
V
R
L
Q
I
-----------------------------------
Q
G
E
-
S
Q
G
L
V
R
-
T
A
A
S
-
A
Q
Y
R
G
V
L
G
T
I
L
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
A
S
V
R
I
---
G
L
Y
D
S
V
K
Q
-
F
Y
----
T
-
K
G
S
----
E
H
A
G
--
I
G
S
R
L
L
A
-----
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
---
D
V
V
K
V
R
F
Q
A
Q
A
R
A
G
---
G
G
R
R
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
V
--------
T
Y
D
L
I
K
D
T
L
L
K
---
A
N
L
M
----
T
D
D
L
P
C
---------
H
F
T
S
A
F
G
A
G
F
C
T
T
V
I
A
S
----
P
V
D
V
V
K
T
R
Y
M
-----
N
S
A
L
G
-----
Q
-----
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
----
E
G
P
R
A
----
F
Y
K
G
F
M
--
P
S
F
L
R
L
--------
G
S
W
N
V
V
M
F
V
T
------
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
--
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
74.03
73%
-66
- C3 -
2LCK
-
UCP2_MOUSE
A:
[14-308]
-------------------------------------------------------------------------------------------
T
V
K
F
L
G
------
A
G
T
A
A
C
I
A
D
L
I
T
F
P
L
D
T
A
K
V
R
L
Q
I
-----------------------------------
Q
G
E
-
S
Q
G
-
L
V
R
T
A
A
S
-
A
Q
Y
R
G
V
L
G
T
I
L
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
A
S
V
R
I
---
G
L
Y
D
S
V
K
Q
-
F
Y
----
T
K
G
S
-----
E
H
A
G
--
I
G
S
R
L
L
A
-----
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
---
D
V
V
K
V
R
F
Q
A
Q
A
R
A
G
---
G
G
R
R
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
V
--------
T
Y
D
L
I
K
D
T
L
L
K
---
A
N
L
M
----
T
D
D
L
P
C
---------
H
F
T
S
A
F
G
A
G
F
C
T
T
V
I
A
S
----
P
V
D
V
V
K
T
R
Y
M
-----
N
S
A
L
G
-----
Q
-----
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
----
E
G
P
R
A
----
F
Y
K
G
F
M
--
P
S
F
L
R
L
--------
G
S
W
N
V
V
M
F
V
T
------
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
--
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
73.87
24%
-47
* C3 *
1OKC
10
ADT1_BOVIN
A:
[2-293]
----------------------------------------------------------------------------------
D
Q
A
L
S
---
F
L
K
D
F
L
A
------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
-----------------------------------
Q
H
A
-
S
K
Q
-
I
S
-
A
E
K
---
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
---
A
F
K
D
K
Y
K
Q
-
I
F
L
GGV
D
R
H
K
Q
----
F
W
R
Y
--
F
A
G
N
L
A
S
-----
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
---
D
F
A
R
T
R
L
A
A
--
D
V
G
K
G
A
A
Q
R
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
--------
V
Y
D
T
A
K
G
M
L
P
D
---
P
K
------
N
V
H
I
I
V
---------
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
S
Y
----
P
F
D
T
V
R
R
R
M
M
M
Q
SGR
K
G
A
D
I
-----
M
-----
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
----
E
G
P
K
A
----
F
F
K
G
A
W
--
S
N
V
L
R
G
--------
M
G
-
G
A
F
V
L
V
L
------
Y
D
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
73.60
24%
-41
- C3 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
----------------------------------------------------------------------------------
D
Q
A
L
S
---
F
L
K
D
F
L
A
------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
-----------------------------------
Q
H
A
-
S
K
Q
-
I
S
---
A
E
-
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
---
A
F
K
D
K
Y
K
Q
-
I
F
----
L
G
G
V
D
RHKQ
F
W
R
Y
--
F
A
G
N
L
A
S
-----
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
---
D
F
A
R
T
R
L
A
A
D
V
G
K
G
A
--
A
Q
R
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
--------
V
Y
D
T
A
K
G
M
L
P
D
---
P
K
------
N
V
H
I
I
V
---------
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
S
Y
----
P
F
D
T
V
R
R
R
M
M
-----
M
Q
S
G
R
KGADI
M
-----
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
----
E
G
P
K
A
----
F
F
K
G
A
W
--
S
N
V
L
R
G
--------
M
G
-
G
A
F
V
L
V
L
------
Y
D
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.61
25%
-43
- C3 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
----------------------------------------------------------------------------------
D
Q
A
L
S
---
F
L
K
D
F
L
A
------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
-----------------------------------
Q
H
A
-
S
K
Q
-
I
S
-
A
E
K
---
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
---
A
F
K
D
K
Y
K
Q
-
I
F
----
L
G
-
G
V
----
D
R
H
K
--
Q
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
---
D
F
A
R
T
R
L
A
A
D
V
--
G
K
G
A
A
Q
R
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
--------
V
Y
D
T
A
K
G
M
L
P
D
PKN
V
H
I
I
----
V
S
W
M
I
A
---------
Q
T
V
T
A
-----
V
A
G
L
V
S
Y
----
P
F
D
T
V
R
R
R
M
M
-----
M
Q
S
G
R
-----
K
GADIM
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
----
E
G
P
K
A
----
F
F
K
G
A
W
--
S
N
V
L
R
---------
G
M
G
G
A
F
V
L
V
L
------
Y
D
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.12
25%
-43
- C3 -
2C3E
4
ADT1_BOVIN
A:
[1-293]
---------------------------------------------------------------------------------
S
D
Q
A
L
S
---
F
L
K
D
F
L
A
------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
-----------------------------------
Q
H
A
-
S
K
Q
-
I
S
-
A
E
K
---
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
---
A
F
K
D
K
Y
K
Q
-
I
F
----
L
G
-
G
V
----
D
R
H
K
--
Q
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
---
D
F
A
R
T
R
L
A
A
D
V
--
G
K
G
A
A
Q
R
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
--------
V
Y
D
T
A
K
G
M
L
P
D
PKN
V
H
I
I
----
V
S
W
M
I
A
---------
Q
T
V
T
A
-----
V
A
G
L
V
S
Y
----
P
F
D
T
V
R
R
R
M
M
-----
M
Q
S
G
R
-----
K
GADIM
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
----
E
G
P
K
A
----
F
F
K
G
A
W
--
S
N
V
L
R
---------
G
M
G
G
A
F
V
L
V
L
------
Y
D
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.35
23%
-43
- C3 -
4C9J
4
ADT3_YEAST
A:
[26-298]
--------------------------------------------------------------------------------------
N
---
F
A
I
N
F
L
M
------
G
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
--
R
V
K
I
L
I
-----------------------------------
Q
N
Q
-
D
E
M
-
I
K
-
Q
G
T
L
D
K
K
Y
S
G
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
---
A
F
K
D
K
I
K
L
-
M
F
----
G
F
K
K
E
----
E
G
Y
G
K
W
F
A
G
N
L
A
S
-----
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
---
D
F
A
R
T
R
L
A
A
D
A
K
S
-----
A
R
Q
F
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
--------
M
F
D
S
L
K
------------------------------------
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
R
R
M
M
M
T
---
S
G
Q
A
V
-----
K
-----
Y
N
G
A
I
D
C
L
K
K
I
V
A
S
----
E
G
V
G
S
----
L
F
K
G
C
G
--
A
N
I
L
R
S
--------
V
A
G
A
G
V
I
S
M
Y
------
D
Q
L
Q
M
I
L
F
G
K
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.02
25%
-45
- C3 -
4C9H
5
ADT2_YEAST
A:
[25-313]
--------------------------------------------------------------------------------------------
I
D
F
L
M
------
G
G
V
S
A
A
V
A
K
T
A
A
S
P
I
E
--
R
V
K
L
L
I
-----------------------------------
Q
N
Q
-
D
E
M
-
L
K
-
Q
G
T
L
D
R
K
Y
A
G
I
L
D
C
F
K
R
T
A
T
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
---
A
F
K
D
K
I
K
A
-
M
F
----
G
F
K
K
E
----
E
G
Y
A
K
W
F
A
G
N
L
A
S
-----
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
---
D
Y
A
R
T
R
L
A
A
D
S
-------
A
R
Q
F
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
--------
M
Y
D
S
L
K
---------------------------------
L
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
R
R
M
M
M
T
---
S
G
Q
A
V
-----
K
-----
Y
D
G
A
F
D
C
L
R
K
I
V
A
A
----
E
G
V
G
S
----
L
F
K
G
C
G
--
A
N
I
L
R
---------
G
V
A
G
A
G
V
I
S
M
------
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.78
23%
-44
- C3 -
4C9Q
5
ADT3_YEAST
A:
[26-298]
--------------------------------------------------------------------------------------
N
---
F
A
I
N
F
L
M
------
G
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
--
R
V
K
I
L
I
-----------------------------------
Q
N
Q
-
D
E
M
-
I
K
-
Q
G
T
L
D
K
K
Y
S
G
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
---
A
F
K
D
K
I
K
L
-
M
F
----
G
F
K
K
E
-----
G
Y
G
K
W
F
A
G
N
L
A
S
-----
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
---
D
F
A
R
T
R
L
A
A
D
A
K
S
-----
A
R
Q
F
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
--------
M
F
D
S
L
K
P
--------
L
----------------------
F
L
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
R
R
M
M
M
T
---
S
G
Q
A
V
-----
K
-----
Y
N
G
A
I
D
C
L
K
K
I
V
A
S
----
E
G
V
G
S
----
L
F
K
G
C
G
--
A
N
I
L
R
S
--------
V
A
G
A
G
V
I
S
M
Y
------
D
Q
L
Q
M
I
L
F
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
53.85
23%
-45
- C3 -
1OKC
8
ADT1_BOVIN
A:
[5-204]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
--
F
L
K
D
F
L
A
-----
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
---
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
Q
I
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
--------
F
K
D
K
Y
K
Q
I
F
L
G
---
G
V
D
R
HKQ
F
W
R
Y
F
A
G
---------
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
----
P
L
D
F
A
R
T
R
L
A
-----
A
D
V
G
K
GAAQR
E
-----
F
T
G
L
G
N
C
I
T
K
I
F
K
S
----
D
G
L
R
G
----
L
Y
Q
G
F
N
--
V
S
V
Q
G
I
--------
I
I
Y
R
A
A
Y
F
G
V
------
Y
D
T
A
K
G
M
L
P
D
P
K
N
V
H
--
I
I
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
52.72
17%
-59
- C2 -
4F3V
-
ECCA1_MYCTU
A:
[1-275]
---------------------------------------------------------------------------------
G
H
M
T
D
R
---
L
A
S
L
F
E
S
------
A
V
S
M
-----
L
P
M
S
E
A
R
S
L
D
L
F
T
E
I
-----------------------------------
T
N
Y
-
D
E
S
-
A
C
-
D
A
W
I
-
G
R
I
R
C
G
D
T
D
R
V
T
L
F
R
A
W
Y
S
R
R
N
F
G
Q
L
S
G
S
V
Q
I
S
M
S
T
L
N
A
R
I
A
I
G
G
L
Y
G
D
I
T
Y
P
V
T
----
S
P
L
A
I
----
T
M
G
F
--
A
A
C
E
A
A
Q
-----
G
N
Y
A
D
A
M
E
A
L
E
A
A
P
V
AGS
E
H
L
V
A
W
M
K
A
V
V
Y
G
A
A
E
R
----
W
T
D
V
I
D
Q
V
K
S
A
G
K
-------
W
P
---
D
K
F
L
A
G
A
A
G
V
A
H
G
V
A
--------
A
A
N
L
A
L
F
T
E
A
E
---
R
R
L
T
----
E
A
N
---------------
D
S
P
A
G
E
A
C
A
R
A
I
A
W
----
Y
L
A
M
A
R
R
S
Q
G
-----
N
----------------
E
S
A
A
V
A
L
L
E
W
L
Q
T
----
T
H
P
E
P
----
K
V
A
A
A
L
K
D
P
S
Y
-----------------------------
R
L
K
T
T
T
A
E
Q
I
A
S
R
--
A
D
P
W
DPGSVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
46.06
25%
-29
- C3 -
2LCK
-
UCP2_MOUSE
A:
[113-302]
------------------------------------------------------------------------------------
H
A
G
---
I
G
S
R
L
L
A
------
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
-----------------------------------
Q
A
R
-
A
G
G
-------
G
-
R
R
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
---
V
T
Y
D
L
I
K
D
-
T
L
----
L
K
A
N
L
----
M
T
D
D
--
L
P
C
H
F
T
S
-----
A
F
G
A
G
F
C
T
T
V
I
A
S
P
V
---
D
V
V
K
T
R
Y
M
N
S
A
L
-------
G
Q
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
V
V
M
F
V
--------
T
Y
E
Q
L
K
R
A
L
M
A
---
A
Y
Q
S
----
R
E
A
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
43.21
11%
-66
- C3 -
1W79
-
DAC_ACTSP
A:
[1-466]
R
L
T
E
L
R
E
D
I
D
A
I
L
E
DPALEG
A
V
S
G
V
V
V
V
DTATGEELYSRDGG
E
Q
L
L
PASN
M
K
L
F
T
A
A
A
A
L
E
V
LGAD
H
S
F
G
T
E
V
A
A
E
S
A
P
G
R
R
G
E
V
Q
D
---
L
Y
L
V
G
R
G
DPTLS
A
E
D
L
D
A
M
A
A
E
V
A
A
S
G
V
R
T
V
R
G
D
L
Y
A
D
DTWFDSERLVDDWWPEDEPYAYSAQISA
L
T
V
A
H
G
E
R
F
-
D
T
G
-
V
T
-
E
V
S
V
-
T
P
A
A
E
G
E
P
A
D
V
D
L
G
A
A
E
G
Y
A
E
L
D
N
R
A
V
T
G
A
A
G
S
A
N
T
L
V
I
D
R
---
P
V
G
T
N
T
I
A
-
V
T
----
G
S
L
P
A
----
D
A
A
P
--
V
T
A
L
R
T
V
-----
D
E
P
A
A
L
A
G
H
L
F
E
E
A
L
---
E
S
N
G
V
T
V
K
G
D
V
G
L
G
G
V
P
A
D
W
Q
D
A
E
V
L
A
D
H
T
S
A
E
L
S
E
I
L
V
P
F
M
K
F
S
N
N
G
H
A
E
M
L
V
K
S
I
G
Q
E
T
AGAGT
W
D
A
G
L
V
G
V
E
E
A
L
S
G
---
L
G
V
D
----
T
A
G
L
V
L
NDGSGLSRG
N
L
V
T
A
D
T
V
V
D
L
L
G
Q
A
G
S
----
A
P
W
A
Q
T
W
S
A
S
-----
L
P
V
A
G
-----
E
-----
S
D
P
F
V
G
G
T
L
A
N
R
M
R
GTAA
E
G
V
V
E
----
A
K
T
G
T
M
--
S
G
V
S
A
L
S
G
Y
V
P
G
PE
G
E
L
A
F
S
I
V
N
N
GHSGPA
P
L
A
V
Q
D
A
I
A
V
R
L
A
E
Y
--
A
G
H
Q
A
P
E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
41.09
8%
-13
- C3 -
3F2E
1
?
A:
[8-59]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
A
V
A
E
Q
V
S
A
V
L
S
Q
Y
G
I
T
G
P
N
R
A
I
Y
Q
G
F
G
L
K
V
A
R
A
L
N
R
L
G
--------
G
G
P
A
L
V
N
M
I
N
G
---
L
K
A
Y
----
Y
I
S
A
F
N
---------
A
N
P
T
V
L
D
A
V
T
D
I
I
T
G
S
P
----
T
G
Y
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
38.03
15%
-39
- C1 -
4ZUZ
-
?
A:
[7-863]
-------------------------------------------D
V
I
K
F
K
EPERCDY
L
Y
V
D
ENN
K
V
H
I
L
L
P
IVGGD
E
I
G
L
D
N
T
C
Q
T
A
V
---
E
L
I
T
F
F
-------
Y
G
S
A
H
S
G
V
T
K
Y
S
A
E
H
Q
L
S
E
Y
K
R
Q
L
-----------------------------------
E
E
D
-
I
K
A
-
I
N
-
S
Q
K
K
-
I
S
P
H
A
Y
D
D
L
L
K
E
K
I
E
R
L
Q
Q
I
E
K
Y
I
E
L
I
Q
V
L
K
K
Q
Y
D
E
Q
N
----------
D
I
R
Q
-
L
R
----
T
G
G
I
P
----
Q
L
P
S
--
G
V
K
E
I
I
K
-----
S
-
S
E
N
A
F
A
V
R
L
S
-
P
Y
---
D
N
D
K
F
T
R
F
D
D
P
L
F
N
V
K
R
N
I
S
K
Y
D
-
T
P
S
R
Q
A
P
I
P
I
Y
E
G
L
G
Y
R
L
R
S
T
L
F
P
-
E
D
K
T
P
T
P
I
N
K
K
S
--------
L
R
D
K
V
K
S
T
V
L
S
---
H
Y
K
D
----
E
D
R
I
D
-------------
G
E
K
K
D
E
K
L
N
E
L
I
T
N
----
L
Q
N
E
L
V
K
E
L
V
-----
K
S
D
P
Q
-----
Y
-----
S
K
L
S
L
S
-----
K
D
P
----
R
G
K
E
I
----
N
Y
D
Y
L
V
--
N
S
L
M
L
V
--------
D
N
D
S
E
I
G
D
W
I
------
D
T
I
L
D
A
T
V
D
S
T
V
W
A
V
QA
S
S
P
F
YQGAKEISS
D
R
D
A
D
K
I
S
I
R
V
Q
Y
L
L
A
E
A
N
I
Y
C
K
T
N
KLSDAN
F
G
E
F
F
D
KE
P
H
A
T
E
I
A
K
R
V
K
E
G
F
T
Q
GAD
I
E
P
I
I
Y
D
Y
I
N
S
NHAELGLKSPLT
G
K
Q
Q
Q
E
I
T
D
K
F
T
K
H
Y
N
T
I
K
ESPHFD
E
F
F
V
A
D
PDKKGN
I
F
S
H
QGRISCH
F
L
D
F
F
T
R
Q
T
KGKHPLGDLAS
H
Q
E
A
L
Q
E
GTSNRLHHKN
E
V
V
A
Q
G
Y
E
K
L
D
Q
F
K
K
E
V
V
K
L
L
A
E
NK
P
K
E
L
L
D
Y
L
V
ATSPTGVPNYSMLS
K
E
T
Q
N
Y
I
A
Y
NRN
W
P
A
I
Q
K
E
L
E
K
ATSIP
E
S
Q
K
Q
D
L
S
R
L
LSRDNLQ
H
D
N
L
S
A
I
T
W
S
KYSSKPL
L
D
V
E
L
N
K
I
A
E
G
L
E
L
T
A
K
I
Y
N
E
K
RGREWWFAGSR
N
E
A
R
K
T
Q
C
E
E
L
Q
R
V
S
K
E
I
N
T
L
L
Q
SESLT
K
S
Q
V
L
E
K
V
L
N
S
I
E
T
L
D
K
I
D
R
D
I
S
A
E
SNWFQS
T
L
Q
K
E
V
R
L
F
R
D
Q
L
K
D
I
C
QLDK
Y
Y
F
K
S
TKLD
E
I
I
S
L
E
M
E
E
Q
F
Q
K
IQD
P
A
V
Q
Q
I
V
R
D
LPSHCHN
D
E
A
I
E
F
F
K
T
L
N
P
E
E
A
A
K
V
A
S
Y
L
S
L
E
Y
R
E
I
N
KSTDK
K
T
L
L
E
Q
D
I
P
R
L
F
K
E
V
N
T
Q
L
L
S
K
L
K
E
E
KAID
E
Q
V
H
E
K
L
S
Q
L
ADKIAPEHFT
R
N
N
I
I
K
W
S
T
8
PsiBlast_PDB
37.05
29%
-35
- C3 -
1S4Q
2
KGUA_MYCTU
A:
[144-204]
------------------------------------------------------------------------------------
P
P
S
W
Q
D
L
Q
A
R
L
I
G
------
R
G
T
E
T
--
A
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
A
-----------------------------------
Q
G
D
F
D
K
V
-
V
V
-
N
R
R
L
-
E
S
A
C
A
E
L
V
S
L
L
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
34.75
40%
192
- C3 -
4QMF
-
FAF1_YEAST
A:
[1-20]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
------
A
E
N
L
Q
N
D
L
E
L
Q
Q
F
L
R
--
E
S
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
31.76
10%
4
- C3 -
3F2E
1
?
A:
[8-60]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
A
V
A
E
Q
V
S
A
V
L
S
Q
----
Y
G
I
T
G
----
P
N
R
A
I
Y
--
Q
G
F
G
L
K
--------
V
A
R
A
L
N
R
L
G
G
------
G
P
A
L
V
N
M
I
N
G
L
K
A
Y
Y
--
I
S
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
27.80
21%
27
- C3 -
3J9X
-
?
A:
[35-81]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
N
F
Q
-----
T
N
V
P
------
K
-----
F
T
S
V
N
E
N
V
S
A
V
L
T
Q
----
Y
G
I
T
G
P
N
R
A
I
Y
Q
G
F
G
--
L
K
V
A
R
A
--------
L
N
R
I
G
S
G
P
A
L
------
V
N
M
I
N
G
L
K
G
Y
Y
I
S
A
F
--
N
A
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
27.29
39%
-49
- C3 -
1RMD
-
A:
[11-38]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
----
A
V
D
F
P
A
---------
H
F
V
K
S
I
S
C
Q
I
C
E
H
I
L
A
D
----
P
V
E
T
S
C
K
H
L
F
-----
C
R
I
C
I
-----
L
-----
R
C
L
K
V
M
G
S
Y
C
P
S
C
R
----
Y
P
C
F
P
----
T
D
L
E
S
P
--
V
K
S
F
L
N
--------
I
L
N
S
L
M
V
K
C
P
------
A
Q
D
C
N
E
E
V
S
L
E
K
Y
N
H
--
H
V
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------