@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UCP4_HUMAN: (2015-12-12 )
MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREMSGVSPF
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20...----.....----30........40----------.........50..-.....----.60........70----..-.....-..80........90..------......100.-......110......---.120--------.---.....-.--.130-...----......140.......150--........160........170---.........180.......190.......200.......210.......220.----......230...----....240.......250...----------.....260.......270.......280..---...--..290.......300..-------.....310.......320.-------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVP
E
E
E
E
RLL
P
L
T
Q
RWP
R
A
S
K
F
L
----
L
S
G
C
A
----
A
T
V
A
E
L
A
TFPL-----------
D
L
T
K
T
R
L
Q
MQ
G
E
A
-
A
L
A
RL----GDGARESAPY
R
G
-----
M
V
-
R
T
A
L
G
-IIEE
E
G
F
L
K
L
W
QGV
T
P
------
A
I
Y
R
H
V
V
YSG-G
R
M
V
T
Y
E
H
L
R
E
V
VFG---KSE---------D---EHY
P
L
-
W
--
K
S
---
V
I
G
----
G
M
M
A
G
V
I
G
Q
F
LANPT
D
L
V
---
K
V
Q
M
Q
MEGK-RKLEGKP
L
R
F-----R
G
V
H
H
A
F
A
K
I
L
A
EGGIRG
L
W
A
GWVPNI
Q
R
A
A
L
VNMGDL
T
T
Y
D
T
V
K
H
Y
L
V
LNTP----LED
N
I
M
T
H
G
L
S
S
----
L
C
S
G
L
V
A
S
I
LGT
P
A
D
V
-
I
K
S
----------
R
IMNQPRDKQG
R
G
L
L
YKSS
T
D
C
L
I
Q
A
VQGE---
G
F
M
--
S
L
Y
K
G
F
L
P
S
W
L
RMTP
W
S
-------
M
V
F
W
L
T
Y
E
K
I
R
E
MSGVSPF-------------------------------------------------------------------------
20
Fugue
82.14
22%
-37
- C1 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
----
A
G
G
V
A
----
A
A
I
S
K
T
A
V
A
P
I
-----------
E
R
V
K
L
L
L
Q
V
Q
H
A
S
-----------
K
Q
I
S
A
E
K
Q
Y
K
G
-----
I
I
-
D
C
V
V
R
-
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
------
N
V
I
R
Y
F
P
T
Q
A
-
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
GVD
R
H
K
---------
Q
---
F
W
R
Y
F
-
A
--
G
N
---
L
A
S
----
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
---
R
T
R
L
A
A
D
V
G
-
K
G
--
A
A
Q
R
E
F
-----
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
--
P
D
P
----
K
N
V
H
I
I
V
S
W
M
I
A
----
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
T
-
V
R
R
----------
R
M
M
M
Q
S
-
G
R
K
G
A
D
I
M
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
E
---
G
P
K
--
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
-------
F
V
L
V
L
Y
D
E
I
-----------------------------------------------------------------------------------
2
PsiBlast_PDB
81.49
23%
-38
- C1 -
1OKC
10
ADT1_BOVIN
A:
[11-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
----
A
G
G
V
A
----
A
A
I
S
K
T
A
V
A
P
I
-----------
E
R
V
K
L
L
L
Q
V
Q
H
A
S
-----------
K
Q
I
S
A
E
K
Q
Y
K
G
-----
I
I
-
D
C
V
V
R
-
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
------
N
V
I
R
Y
F
P
T
Q
A
-
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
----
G
V
---------
D
---
R
H
K
Q
F
-
W
--
R
Y
---
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
---
R
T
R
L
A
A
D
V
G
-
K
G
A
A
Q
R
--
E
F
-----
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
--
M
L
P
D
P
----
K
N
V
H
I
I
V
S
W
M
I
A
----
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
T
-
V
R
R
----------
R
M
M
M
Q
S
-
G
R
K
G
A
D
I
M
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
E
---
G
P
K
--
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
-------
F
V
L
V
L
-
Y
D
E
I
----------------------------------------------------------------------------------
3
PsiBlast_PDB
81.44
23%
-38
- C1 -
2C3E
4
ADT1_BOVIN
A:
[11-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
----
A
G
G
V
A
----
A
A
I
S
K
T
A
V
A
P
I
-----------
E
R
V
K
L
L
L
Q
V
Q
H
A
S
-----------
K
Q
I
S
A
E
K
Q
Y
K
G
-----
I
I
-
D
C
V
V
R
-
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
------
N
V
I
R
Y
F
P
T
Q
A
-
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
----
G
V
---------
D
---
R
H
K
Q
F
-
W
--
R
Y
---
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
---
R
T
R
L
A
A
D
V
G
-
K
G
A
A
Q
R
--
E
F
-----
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
--
M
L
P
D
P
----
K
N
V
H
I
I
V
S
W
M
I
A
----
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
T
-
V
R
R
----------
R
M
M
M
Q
S
-
G
R
K
G
A
D
I
M
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
E
---
G
P
K
--
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
-------
F
V
L
V
L
-
Y
D
E
I
----------------------------------------------------------------------------------
11
HHSearch
78.74
21%
-39
- C1 -
1OKC
10
ADT1_BOVIN
A:
[4-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
F
L
K
D
F
L
----
A
G
G
V
A
----
A
A
I
S
K
T
A
V
A
P
I
-----------
E
R
V
K
L
L
L
Q
V
Q
H
A
S
-
K
Q
I
S
----------
A
E
K
Q
Y
K
G
-----
I
I
-
D
C
V
V
R
-
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
------
N
V
I
R
Y
F
P
T
Q
A
-
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
---
G
V
D
---------
R
HKQ
F
W
R
Y
F
-
A
--
G
N
---
L
A
S
----
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
---
R
T
R
L
A
A
D
V
G
-
K
G
A
--
A
Q
R
E
F
-----
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
P
D
P
K
------
N
V
H
I
I
V
S
W
M
I
A
----
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
T
-
V
R
R
----------
R
M
M
M
Q
S
G
R
K
G
A
-
D
I
M
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
E
---
G
P
K
--
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
-
G
-------
A
F
V
L
V
L
Y
D
E
I
----------------------------------------------------------------------------------
4
PsiBlast_PDB
71.25
24%
-32
- C1 -
4C9J
4
ADT3_YEAST
A:
[25-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
F
A
I
N
F
L
----
M
G
G
V
S
----
A
A
I
A
K
T
A
A
S
P
I
-----------
E
R
V
K
I
L
I
Q
N
Q
D
E
M
-----
I
----
K
Q
G
T
L
D
K
-
K
Y
S
G
-----
I
V
-
D
C
F
K
R
-
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
------
N
V
I
R
Y
F
P
T
Q
A
-
L
N
F
A
F
K
D
K
I
K
-
L
M
F
G
---
F
K
K
---------
E
---
E
G
Y
G
K
-
W
F
A
G
N
---
L
A
S
----
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
---
R
T
R
L
A
A
D
A
K
-
S
-----
A
R
Q
F
-----
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
F
D
S
L
K
--------------------
F
L
L
G
----
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
T
-
V
R
R
----------
R
M
M
M
T
S
----
G
Q
A
V
K
Y
N
G
A
I
D
C
L
K
K
I
V
A
S
E
---
G
V
G
--
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
-------
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
--------------------------------------------------------------------------
5
PsiBlast_PDB
71.09
24%
-34
- C1 -
4C9Q
5
ADT3_YEAST
A:
[23-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
T
N
F
A
I
N
F
L
----
M
G
G
V
S
----
A
A
I
A
K
T
A
A
S
P
I
-----------
E
R
V
K
I
L
I
Q
N
Q
D
E
M
-----
I
----
K
Q
G
T
L
D
K
-
K
Y
S
G
-----
I
V
-
D
C
F
K
R
-
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
------
N
V
I
R
Y
F
P
T
Q
A
-
L
N
F
A
F
K
D
K
I
K
-
L
M
F
G
---
F
K
K
---------
E
----
G
Y
G
K
-
W
F
A
G
N
---
L
A
S
----
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
---
R
T
R
L
A
A
D
A
K
-
S
-----
A
R
Q
F
-----
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
F
D
S
L
K
P
-
L
-------------
F
L
A
S
F
L
L
G
----
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
T
-
V
R
R
----------
R
M
M
M
T
S
----
G
Q
A
V
K
Y
N
G
A
I
D
C
L
K
K
I
V
A
S
E
---
G
V
G
--
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
-------
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
----------------------------------------------------------------------------
22
Fugue
69.97
18%
-62
- C1 -
4P5W
-
CMC2_HUMAN
A:
[31-394]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TK
R
A
D
P
A
E
L
R
T
I
F
L
K
Y
A
S
I
E
K
N
G
E
F
F
----
M
S
----------------
P
N
-----------
D
F
V
T
R
Y
L
N
I
F
S
Q
P
-
N
-----------
P
K
T
V
E
L
L
S
G
-----
V
V
D
Q
T
K
D
G
-
L
I
S
F
Q
E
F
V
A
F
E
S
V
L
C
A
PD
A
L
F
M
V
A
F
Q
L
F
D
K
A
G
-
K
G
E
V
T
F
E
D
V
K
Q
V
F
G
Q
---
T
T
I
---------
H
---
Q
H
I
P
F
N
W
--
D
S
---
E
F
V
----
Q
L
H
F
G
K
E
R
K
R
H
L
T
Y
A
E
F
T
---
Q
F
L
L
E
I
Q
L
E
-
H
A
K
Q
A
F
V
Q
R
D
NARTG
R
V
T
A
I
D
F
R
D
I
M
V
T
I
R
P
H
V
L
----
T
P
F
V
E
E
C
L
V
A
A
A
G
G
T
T
S
H
Q
V
S
F
S
Y
F
N
G
F
N
S
----
L
L
N
N
------
M
E
----
L
I
R
K
I
Y
S
T
L
A
G
T
R
K
D
V
E
V
T
K
----------
E
E
F
V
L
A
A
Q
K
F
G
Q
--
V
T
P
M
E
V
D
I
L
F
Q
L
A
D
L
Y
EPR
G
R
M
--
T
-----
L
A
D
I
E
R
I
A
P
P
N
PDHV
G
G
Y
K
L
A
V
A
T
F
A
G
I
E
N
K
F
G
L
Y
L
--------------------------------------------------------------------------
6
PsiBlast_PDB
69.86
25%
-36
- C1 -
4C9H
5
ADT2_YEAST
A:
[27-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
----
M
G
G
V
S
----
A
A
V
A
K
T
A
A
S
P
I
-----------
E
R
V
K
L
L
I
Q
N
Q
D
E
---
M
L
K
Q
----
G
T
L
D
R
K
---
Y
A
G
-----
I
L
-
D
C
F
K
R
-
T
A
T
Q
E
G
V
I
S
F
W
R
G
N
T
A
------
N
V
I
R
Y
F
P
T
Q
A
-
L
N
F
A
F
K
D
K
I
K
-
A
M
F
G
---
F
K
K
---------
E
---
E
G
Y
A
K
-
W
F
A
G
N
---
L
A
S
----
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
Y
A
---
R
T
R
L
A
A
D
S
--------
A
R
Q
F
-----
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
Y
D
S
L
K
-----------------
L
A
S
F
L
L
G
----
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
T
-
V
R
R
----------
R
M
M
M
T
S
----
G
Q
A
V
K
Y
D
G
A
F
D
C
L
R
K
I
V
A
A
E
---
G
V
G
--
S
L
F
K
G
C
G
A
N
I
L
R
G
V
A
G
A
-------
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
-------------------------------------------------------------------------
23
Fugue
69.85
16%
-55
- C1 -
3N6O
-
DRRA_LEGPH
A:
[1-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
V
T
R
I
E
N
L
E
N
A
K
K
L
W
D
N
A
N
S
M
L
E
K
GN
I
S
G
Y
L
----
K
A
A
N
E
L
H
K
F
M
K
E
K
NLKEDDLRP
E
L
S
D
K
T
I
S
P
K
G
Y
A
-
I
L
Q
S
L
----
W
G
A
A
S
D
---
Y
S
R
-----
A
A
-
A
T
L
T
E
-
S
T
V
E
P
G
L
V
S
A
V
N
K
M
S
A
------
F
F
M
D
C
K
L
S
P
N
-
E
R
----------------
A
T
P
---------
D
---
P
D
F
K
V
-
G
--
K
S
---
K
I
L
----
V
G
I
M
Q
F
I
K
D
V
-
A
D
P
T
S
K
I
WMH
N
T
K
A
L
M
N
H
K
I
A
A
I
Q
K
L
E
R
S
N
-----
N
V
N
D
E
T
L
E
S
V
L
S
S
K
G
E
N
-----------
L
S
E
Y
L
S
Y
K
Y
A
T
K
D
E
G
R
E
H
R
Y
T
A
S
T
E
----
N
F
K
N
V
K
----------------
E
K
Y
Q
Q
M
R
G
D
A
-
L
K
T
----------
E
I
L
A
D
F
K
D
K
L
-
A
E
A
T
D
E
Q
S
L
K
Q
I
V
A
E
L
K
S
K
---
D
E
Y
--
R
I
L
A
K
G
Q
G
L
T
T
Q
L
L
G
L
K
-------
T
S
S
V
S
S
F
E
K
M
V
E
E
T
R
E
S
I
K
SQ-----------------------------------------------------------------------
1
PsiBlast_PDB
67.17
34%
-40
- C1 -
2LCK
-
UCP2_MOUSE
A:
[16-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
L
----
G
A
G
T
A
----
A
C
I
A
D
L
I
T
F
P
L
-----------
D
T
A
K
V
R
L
Q
I
Q
G
E
S
Q
G
L
V
R
T
----
A
----
A
S
A
Q
Y
R
G
-----
V
L
-
G
T
I
L
T
-
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
V
A
------
G
L
Q
R
Q
M
S
F
A
S
-
V
R
I
G
L
Y
D
S
V
K
Q
--
F
Y
---
T
K
G
---------
S
---
E
H
A
G
I
-
G
--
S
R
---
L
L
A
----
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
---
K
V
R
F
Q
A
Q
A
R
----
A
G
G
G
R
R
Y
-----
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
T
L
L
K
A
N
L
----
M
T
D
D
L
P
C
H
F
T
S
A
----
F
G
A
G
F
C
T
T
V
I
A
S
P
V
D
V
-
V
K
T
----------
R
Y
M
N
S
A
L
G
Q
------
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
E
---
G
P
R
--
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
-------
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
-------------------------------------------------------------------------
26
Fugue
66.96
17%
-39
- C1 -
4PWO
1
?
A:
[1-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
A
E
K
T
A
T
D
L
P
P
G
F
S
G
K
A
G
S
V
N
A
----
T
P
G
T
K
GLD
G
P
T
P
L
A
D
G
S
F
D
A
-----------
T
I
F
G
P
A
K
E
L
K
S
A
D
-
D
I
L
N
V
----
H
R
R
N
A
K
D
P
F
A
V
G
AVDAP
L
V
-
I
T
E
F
S
-
D
F
E
C
P
F
C
A
R
W
S
N
Q
T
E
P
------
T
L
M
E
E
Y
V
S
K
G
-
L
V
R
I
E
W
N
D
L
P
V
-----------------------
N
G
E
H
A
-
L
--
A
A
---
A
K
A
----
G
R
A
A
A
A
Q
G
K
F
D
E
F
R
K
A
L
F
---
E
A
S
-------
R
N
V
S
G
H
P
--------
N
N
T
L
K
D
F
E
R
F
A
R
N
A
G
V
K
----------------
D
M
E
R
F
S
R
E
A
Q
D
S
T
Y
D
E
V
L
A
K
----
A
A
D
Y
A
H
G
L
G
V
S
---------------
G
T
P
A
F
V
-
V
G
T
----------
Q
Y
I
S
G
A
Q
-----------
P
T
E
E
F
I
K
V
I
E
S
E
---
L
K
K
--
S
---------------------------------
P
T
F
S
T
P
S
S
H
-------------------------------------------------------------------------
10
HHSearch
66.24
34%
-41
- C1 -
2LCK
-
UCP2_MOUSE
A:
[15-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
L
----
G
A
G
T
A
----
A
C
I
A
D
L
I
T
F
P
L
-----------
D
T
A
K
V
R
L
Q
I
Q
G
E
S
-
Q
G
L
V
-------
R
T
A
A
S
A
Q
Y
R
G
-----
V
L
-
G
T
I
L
T
-
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
V
A
------
G
L
Q
R
Q
M
S
F
A
S
-
V
R
I
G
L
Y
D
S
V
K
Q
F
Y
T
K
---
G
S
--------------
E
H
A
G
I
-
G
--
S
R
---
L
L
A
----
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
---
K
V
R
F
Q
A
Q
A
R
-
A
G
---
G
G
R
R
Y
-----
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
T
L
L
K
A
N
L
----
M
T
D
D
L
P
C
H
F
T
S
A
----
F
G
A
G
F
C
T
T
V
I
A
S
P
V
D
V
-
V
K
T
----------
R
Y
M
N
S
A
L
G
------
Q
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
E
---
G
P
R
--
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
-------
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
-------------------------------------------------------------------------
25
Fugue
56.31
14%
-62
- C1 -
4U1D
-
EIF3A_YEAST
A:
[9-496]
------------------------------------------------------------------------------------------------------------------------FR
P
E
N
A
I
K
R
A
D
E
L
I
S
V
GE
K
Q
A
A
L
Q
S
L
H
D
F
I
T
ARRIRWATPSTV
E
P
V
V
F
K
F
L
E
I
G
V
E
L
K
K
G
K
L
L
K
D
G
L
H
Q
Y
K
K
L
I
Q
G
S
T
E
G
----
L
V
S
V
G
----
A
V
A
R
K
F
I
D
L
V
E
-----------
S
K
I
A
S
E
Q
T
R
A
D
E
L
-
Q
K
Q
E
I
----
D
A
I
T
S
W
L
R
F
T
W
E
-----
S
Y
-
R
A
V
L
D
-
L
L
R
N
N
A
L
L
E
I
T
Y
S
G
V
V
------
K
K
T
M
H
F
C
L
K
Y
-
Q
R
K
N
E
F
K
R
L
A
E
M
L
R
Q
---
H
L
D
---------
A
---
A
N
Y
Q
Q
-
S
--
K
S
GNN
L
V
D
----
L
S
D
A
D
T
L
Q
R
Y
L
D
Q
R
F
Q
Q
V
---
D
V
S
V
K
L
E
-----
L
W
H
E
A
Y
R
S
-----
I
E
D
V
F
H
L
M
K
I
S
K
R
A
P
K
P
S
T
L
A
N
Y
Y
E
N
L
V
K
V
F
F
V
S
-
G
D
P
L
L
H
T
T
A
W
K
K
F
Y
K
L
Y
S
----
T
N
P
R
A
T
E
E
E
F
K
T
----
Y
S
S
T
I
F
L
S
A
I
S
T
Q
L
D
E
-
I
P
S
I
GYDPH
L
R
M
Y
R
L
L
N
L
D
A
K
P
T
R
K
E
M
L
Q
S
I
I
E
D
E
S
I
Y
G
K
V
D
E
---
E
L
K
--
E
L
Y
D
I
I
E
V
N
F
-
D
V
D
T
V
K
-------
Q
Q
L
E
N
L
L
V
K
L
S
S
K
T
Y
F
S
Q
Y
I
A
P
L
R
D
V
I
M
R
R
V
F
V
A
A
S
Q
K
F
TTVS
Q
S
E
L
Y
K
L
A
TLPAPL
D
L
S
A
W
D
I
E
K
S
L
L
Q
A
A
V
E
DY
V
S
I
T
I
DHESA
K
V
T
F
A
K
12
HHSearch
54.37
17%
-48
- C1 -
1OKC
8
ADT1_BOVIN
A:
[4-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
F
-
L
--
K
D
---
F
L
A
----
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
---
K
L
L
L
Q
V
Q
H
A
-
S
K
Q
I
S
A
E
K
Q
Y
-----
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
V
D
RHKQ
F
W
R
Y
F
A
G
N
L
A
S
G
----
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
-
A
R
T
----------
R
L
A
A
D
V
G
K
G
A
-
A
Q
R
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
---
G
L
R
--
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
-------
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
P
D
P
K
N
-------------------------------------------------------------------------
21
Fugue
52.04
14%
-58
- C1 -
2BVL
6
TOXB_PEPDI
A:
[1-543]
MSLVN
R
K
Q
L
E
K
M
A
NVRFRTQE
D
E
Y
V
A
I
L
D
A
L
E
E
Y
H
N
MSENT
V
V
E
K
Y
L
K
L
K
D
I
N
S
L
T
D
I
C
I
D
T
Y
KKSGR
N
K
A
L
K
K
F
K
E
Y
L
V
T
E
V
L
E
L
K
N
N
NLTPVEK
N
L
H
F
V
W
I
GGQIN
D
T
A
I
N
Y
I
N
Q
W
K
D
V
N
SD
Y
N
V
N
V
F
Y
D
SNAFL
I
N
T
L
K
K
T
V
V
E
S
A
I
N
D
T
L
E
S
F
RENLNDPRFD
Y
N
K
F
F
R
K
R
M
E
I
I
Y
D
K
Q
K
N
F
I
N
Y
Y
K
A
Q
R
E
E
N
P
E
L
----
I
--
I
D
----
D
I
V
K
T
Y
L
S
N
E
Y
-----------
S
K
E
I
D
E
L
N
T
Y
I
E
E
-
S
L
N
K
I
T
Q
N
S
G
N
D
V
R
N
F
G
E
F
K
N
--------
G
E
S
F
N
-
L
Y
E
Q
E
L
V
E
R
W
N
L
A
A
A
S
------
D
I
L
R
I
S
A
L
K
E
I
G
G
M
Y
L
D
V
D
M
---
L
P
G
---
I
Q
P
---------
D
-------
L
-
F
--
E
S
---
I
--------------
E
K
P
S
S
V
T
V
D
F
---
W
E
M
T
K
L
E
A
I
-
M
K
Y
K
E
Y
I
P
E
Y
-----
T
S
E
H
F
D
M
L
D
E
E
V
Q
S
S
F
E
S
V
L
A
S
--
K
S
D
K
S
E
I
F
S
S
L
G
D
M
E
A
S
P
-
L
E
V
K
I
A
F
N
S
K
-------
G
I
I
N
Q
G
L
I
S
V
K
DS
Y
C
S
N
L
I
V
K
Q
I
E
N
R
Y
K
I
-
L
N
N
----------
S
L
N
P
A
I
S
E
D
N
D
----
F
N
T
T
T
N
T
F
I
D
S
I
M
A
E
---
A
N
A
DN
G
R
F
M
M
E
L
G
K
Y
L
R
V
G
------------
F
F
P
D
V
K
T
T
I
N
L
S
G
P
E
A
Y
A
A
A
Y
Q
D
L
L
M
FKEGSMNIHLI
E
A
D
L
R
N
F
EISKTNISQST
E
Q
E
M
A
SLWSFD
D
A
R
A
K
A
Q
F
E
E
Y
K
R
N
Y
F
E
GAL----
13
HHSearch
48.06
23%
-30
- C1 -
2LCK
-
UCP2_MOUSE
A:
[115-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
G
S
R
L
L
----
A
G
S
T
T
----
G
A
L
A
V
A
V
A
Q
P
T
-----------
D
V
V
K
V
R
F
Q
A
Q
A
R
A
-
G
-------------
G
G
R
R
Y
Q
S
-----
T
V
-
E
A
Y
K
T
-
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
------
N
V
A
R
N
A
I
V
N
C
-
A
E
L
V
T
Y
D
L
I
K
D
T
L
L
K
---
A
N
----------
L
---
M
T
D
D
L
-
P
--
C
H
---
F
T
S
----
A
F
G
A
G
F
C
T
T
V
I
A
S
P
V
D
V
V
---
K
T
R
Y
M
N
S
A
L
--------
G
Q
Y
-----
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
----
S
R
E
A
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
40.78
17%
-10
- C1 -
3K9I
-
?
A:
[54-163]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
A
V
P
Y
Y
E
K
A
I
----
A
S
G
------
L
Q
G
K
D
L
A
E
C
Y
L
-----------
G
L
G
S
T
F
R
T
L
G
E
Y
R
-
K
A
E
A
V
----
L
A
N
G
V
K
Q
F
P
N
H
Q
-----
A
L
-
R
V
F
Y
A
M
V
L
Y
N
L
G
--
R
Y
E
Q
G
V
E
L
------
L
L
K
I
I
A
E
T
S
D
-
D
E
T
I
Q
S
Y
K
Q
A
I
L
F
Y
A
---
D
K
L
---------
D
---
E
T
W
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
37.57
11%
-44
- C1 -
3F2E
1
?
A:
[8-89]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
A
-----
V
A
-
E
Q
V
S
A
-
V
L
S
Q
Y
G
I
T
G
P
N
R
A
I
Y
Q
------
G
F
G
L
K
V
A
R
A
L
-
N
R
L
G
G
G
P
A
L
V
N
M
I
N
G
---
L
K
A
Y
Y
I
S
AFNAN
P
---
T
V
L
D
A
-
V
--
T
D
---
I
I
T
----
G
S
P
T
G
Y
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
36.13
36%
-14
- C3 -
4B52
2
?
A:
[181-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
P
N
I
A
G
D
A
L
R
S
M
S
N
P
T
L
Y
D
Q
P
D
H
Y
S
N
L
Y
T
G
----
S
S
D
N
G
G
V
H
T
N
S
G
----
I
I
N
K
A
Y
Y
L
L
A
Q
G
G
T
F
H
-
G
V
T
----------
V
N
G
I
G
R
D
A
A
V
Q
I
Y
Y
S
A
F
T
N
Y
L
T
S
S
S
D
F
S
N
A
---
R
A
A
--
V
I
Q
A
A
K
D
Q
Y
G
A
N
S
A
E
A
T
-------
A
A
A
K
S
F
D
A
V
G
V
N
--------------------------------------------------------------------------------
15
HHSearch
33.63
13%
-48
- C1 -
3F2E
1
?
A:
[8-59]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-----
T
A
V
A
E
Q
V
S
A
V
L
S
Q
Y
G
I
T
G
P
N
R
A
I
Y
Q
G
F
G
L
K
V
A
R
A
L
N
R
L
G
G
G
P
A
L
V
N
M
I
N
G
L
K
A
----
Y
Y
I
S
A
F
N
A
N
P
T
V
----
L
D
A
V
T
D
I
I
T
G
S
P
T
G
Y
V
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------