@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UT2_HUMAN: (2015-12-12 )
MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSHIVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFIDWVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGMFYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIFRLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFHIEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTSWIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSGILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSDKGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFFPTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYLSQERNRRASIITKYQAYDVS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.--......150.-......160....--------...170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430......-.440.......450.......460.......470.--......480.......490.......500.......510.......520.......530.......540.......550......---.560.......570.......580.......590.......600...--....610.....-..620......--------.630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730...-....740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSDPHSSPLLPEP
L
S
SR
Y
K
L
Y
E
A
EFTSPSWPSTSPDTHPAL
P
L
LEMP
E
E
K
DLRSSNEDS
H
I
V
K
I
EKL
N
E
R
SKRKDDGVAHRDSAG
Q
R
C
I
C
L
S
K
A
V
G
Y
LTGD
M
K
E
Y
R
I
W
LKD
K
H
L
A
L
Q
F
I
D
W
V
L
RGT
A
Q
V
M
F
INNPL
S
G
L
I
I
F
I
--
G
L
L
IQNP
W
W
T
-
I
TG
G
L
G
T
V
V
S
T
L
T
--------
A
L
ALGQ
D
R
S
A
I
A
S
G
LHGY
N
G
M
L
V
G
L
L
M
A
V
F
S
EKL
D
Y
Y
W
W
L
L
F
P
V
T
F
T
AMS
C
P
V
L
S
S
A
L
N
S
I
F
S
KWDL
P
V
F
T
L
P
F
N
I
A
V
T
L
Y
L
A
ATGH
Y
N
L
F
F
P
T
T
L
V
E
P
V
S
SVPN
I
T
W
TEME
M
P
L
L
L
Q
AIPVGVGQVYGCDNPWT
G
G
V
F
L
V
A
L
F
ISS
P
L
I
C
L
H
A
A
I
G
S
I
V
G
L
L
A
A
L
SVAT
P
F
E
T
I
Y
T
G
L
W
S
Y
N
C
V
L
S
C
I
A
IG
G
M
F
Y
A
L
T
W
Q
T
H
L
L
A
L
I
C
A
L
F
C
A
Y
M
E
A
A
I
S
N
I
M
S
V
VGVPP
G
T
W
A
F
C
L
A
T
I
I
F
L
LLTTNN
P
A
I
F
R
LPLSKVTYPEA
N
R
I
Y
Y
L
-
T
VKSGEEEKAPSGGGGEHPPTAGPKVEE
G
S
E
A
V
L
S
--KHR
S
V
F
H
I
E
W
S
S
I
R
R
R
S
K
VFGKGE
H
Q
ERQNKDPFPYRYRKP
T
V
E
L
L
DLDTMEESS
E
I
K
V
E
TNIS
K
T
S
W
I
R
S
S
M
AAS
G
K
R
V
S
K
A
L
S
---
Y
I
T
G
E
M
K
E
C
G
EGLKDKS
P
V
F
Q
F
F
D
W
V
LRGT
S
Q
V
M
F
VNNP
L
S
G
I
L
I
I
L
--
G
L
F
IQN
P
W
W
A
I
S
-
G
C
L
G
T
I
M
S
T
L
T
--------
A
L
I
LSQD
K
S
A
I
A
A
GFHG
Y
N
G
V
L
V
G
L
L
M
A
V
FSDKG
D
Y
Y
W
W
L
L
L
P
V
I
I
M
SMS
C
P
I
L
S
S
A
L
G
T
I
F
S
KWDL
P
V
F
T
L
P
F
N
I
T
V
T
L
Y
L
A
ATGH
Y
N
L
F
F
P
T
TLLQPASAMPNI
T
-
W
S
EV
Q
V
P
L
L
L
R
AIPVG
I
G
QVYGCDNPWT
G
G
I
F
L
I
A
L
F
ISS
P
L
I
C
L
H
A
A
I
G
S
T
M
G
M
L
A
A
L
T
IAT
P
F
D
S
I
Y
F
G
LCGFNS
T
L
A
C
I
A
IG
G
M
F
Y
V
I
TW
Q
T
H
L
L
A
I
A
C
A
L
F
A
A
Y
L
G
A
A
L
A
N
M
L
S
V
FGLPPC
T
W
P
F
C
L
S
A
L
T
F
L
L
L
TTNN
P
A
I
Y
K
LPLSKVTYPEA
N
R
I
Y
Y
L
SQERNR
R
A
S
I
I
T
K
Y
Q
AYDVS
1
PsiBlast_PDB
99.84
63%
-146
- C2 -
4EZC
8
UT1_BOVIN
A:
[31-375]
-----------------------------------------------------------------------------------------------
G
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
K
P
Q
A
L
Q
F
V
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
--
G
L
L
V
Q
N
P
W
C
A
-
L
N
G
C
V
G
T
V
V
S
T
L
T
--------
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
L
M
A
I
Y
S
D
K
G
N
Y
F
W
W
L
L
F
P
V
S
A
M
S
M
T
C
P
V
F
S
S
A
L
N
S
V
L
S
K
W
D
L
P
V
F
T
L
P
F
N
M
A
L
S
M
Y
L
S
A
T
G
H
Y
N
P
F
F
P
S
T
L
I
T
P
V
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
F
L
G
A
I
L
L
S
S
P
L
M
C
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
L
S
A
P
F
E
D
I
Y
A
G
L
W
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
M
A
L
T
W
Q
T
H
L
L
A
L
A
C
A
L
F
T
A
Y
L
G
A
S
M
S
H
V
M
A
V
V
G
L
P
S
G
T
W
P
F
C
L
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
S
K
V
T
Y
P
E
E
N
R
I
F
Y
L
-
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_CBE
99.33
63%
-146
- C2 -
4EZC
9
UT1_BOVIN
B:
[31-376]
-----------------------------------------------------------------------------------------------
G
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
K
P
Q
A
L
Q
F
V
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
--
G
L
L
V
Q
N
P
W
C
A
-
L
N
G
C
V
G
T
V
V
S
T
L
T
--------
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
L
M
A
I
Y
S
D
K
G
N
Y
F
W
W
L
L
F
P
V
S
A
M
S
M
T
C
P
V
F
S
S
A
L
N
S
V
L
S
K
W
D
L
P
V
F
T
L
P
F
N
M
A
L
S
M
Y
L
S
A
T
G
H
Y
N
P
F
F
P
S
T
L
I
T
P
V
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
F
L
G
A
I
L
L
S
S
P
L
M
C
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
L
S
A
P
F
E
D
I
Y
A
G
L
W
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
M
A
L
T
W
Q
T
H
L
L
A
L
A
C
A
L
F
T
A
Y
L
G
A
S
M
S
H
V
M
A
V
V
G
L
P
S
G
T
W
P
F
C
L
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
S
K
V
T
Y
P
E
E
N
R
I
F
Y
L
-
Q
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
99.13
63%
-147
- C2 -
4EZD
10
UT1_BOVIN
A:
[31-375]
-----------------------------------------------------------------------------------------------
G
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
K
P
Q
A
L
Q
F
V
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
--
G
L
L
V
Q
N
P
W
C
A
-
L
N
G
C
V
G
T
V
V
S
T
L
T
--------
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
L
M
A
I
Y
S
D
K
G
N
Y
F
W
W
L
L
F
P
V
S
A
M
S
M
T
C
P
V
F
S
S
A
L
N
S
V
L
S
K
W
D
L
P
V
F
T
L
P
F
N
M
A
L
S
M
Y
L
S
A
T
G
H
Y
N
P
F
F
P
S
T
L
I
T
P
V
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
F
L
G
A
I
L
L
S
S
P
L
M
C
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
L
S
A
P
F
E
D
I
Y
A
G
L
W
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
M
A
L
T
W
Q
T
H
L
L
A
L
A
C
A
L
F
T
A
Y
L
G
A
S
M
S
H
V
M
A
V
V
G
L
P
S
G
T
W
P
F
C
L
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
S
K
V
T
Y
P
E
E
N
R
I
F
Y
L
-
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
99.08
63%
-145
- C2 -
4EZD
10
UT1_BOVIN
B:
[31-376]
-----------------------------------------------------------------------------------------------
G
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
K
P
Q
A
L
Q
F
V
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
--
G
L
L
V
Q
N
P
W
C
A
-
L
N
G
C
V
G
T
V
V
S
T
L
T
--------
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
L
M
A
I
Y
S
D
K
G
N
Y
F
W
W
L
L
F
P
V
S
A
M
S
M
T
C
P
V
F
S
S
A
L
N
S
V
L
S
K
W
D
L
P
V
F
T
L
P
F
N
M
A
L
S
M
Y
L
S
A
T
G
H
Y
N
P
F
F
P
S
T
L
I
T
P
V
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
F
L
G
A
I
L
L
S
S
P
L
M
C
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
L
S
A
P
F
E
D
I
Y
A
G
L
W
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
M
A
L
T
W
Q
T
H
L
L
A
L
A
C
A
L
F
T
A
Y
L
G
A
S
M
S
H
V
M
A
V
V
G
L
P
S
G
T
W
P
F
C
L
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
S
K
V
T
Y
P
E
E
N
R
I
F
Y
L
-
Q
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_CBE
98.76
63%
-145
- C2 -
4EZC
11
UT1_BOVIN
C:
[31-376]
-----------------------------------------------------------------------------------------------
G
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
K
P
Q
A
L
Q
F
V
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
--
G
L
L
V
Q
N
P
W
C
A
-
L
N
G
C
V
G
T
V
V
S
T
L
T
--------
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
L
M
A
I
Y
S
D
K
G
N
Y
F
W
W
L
L
F
P
V
S
A
M
S
M
T
C
P
V
F
S
S
A
L
N
S
V
L
S
K
W
D
L
P
V
F
T
L
P
F
N
M
A
L
S
M
Y
L
S
A
T
G
H
Y
N
P
F
F
P
S
T
L
I
T
P
V
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
F
L
G
A
I
L
L
S
S
P
L
M
C
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
L
S
A
P
F
E
D
I
Y
A
G
L
W
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
M
A
L
T
W
Q
T
H
L
L
A
L
A
C
A
L
F
T
A
Y
L
G
A
S
M
S
H
V
M
A
V
V
G
L
P
S
G
T
W
P
F
C
L
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
S
K
V
T
Y
P
E
E
N
R
I
F
Y
L
-
Q
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_CBE
98.64
63%
-146
- C2 -
4EZD
10
UT1_BOVIN
C:
[31-376]
-----------------------------------------------------------------------------------------------
G
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
K
P
Q
A
L
Q
F
V
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
--
G
L
L
V
Q
N
P
W
C
A
-
L
N
G
C
V
G
T
V
V
S
T
L
T
--------
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
L
M
A
I
Y
S
D
K
G
N
Y
F
W
W
L
L
F
P
V
S
A
M
S
M
T
C
P
V
F
S
S
A
L
N
S
V
L
S
K
W
D
L
P
V
F
T
L
P
F
N
M
A
L
S
M
Y
L
S
A
T
G
H
Y
N
P
F
F
P
S
T
L
I
T
P
V
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
F
L
G
A
I
L
L
S
S
P
L
M
C
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
L
S
A
P
F
E
D
I
Y
A
G
L
W
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
M
A
L
T
W
Q
T
H
L
L
A
L
A
C
A
L
F
T
A
Y
L
G
A
S
M
S
H
V
M
A
V
V
G
L
P
S
G
T
W
P
F
C
L
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
S
K
V
T
Y
P
E
E
N
R
I
F
Y
L
-
Q
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
81.01
33%
-139
- C2 -
3K3F
-
UT_DESVH
A:
[2-337]
-----------------------------------------------------------------------------------------------------
G
R
A
F
G
E
Q
L
L
K
-
N
P
L
I
E
F
C
D
S
V
C
R
G
C
G
Q
V
M
F
Q
N
N
T
V
T
G
L
L
F
F
A
--
G
I
F
Y
N
S
T
T
L
G
-
V
C
A
V
L
G
T
A
A
S
T
L
T
--------
A
Q
L
L
G
V
D
K
P
L
V
R
A
G
L
F
G
F
N
G
T
L
A
G
I
A
L
P
F
F
---
F
N
Y
E
P
A
M
L
G
Y
V
A
L
N
G
A
F
T
T
I
I
M
A
S
L
L
N
F
L
G
K
W
G
V
P
A
L
T
A
P
F
V
L
A
T
W
L
L
M
F
G
V
Y
K
L
S
L
F
H
P
G
A
L
I
A
P
--
A
L
P
S
V
D
M
G
T
V
T
G
R
T
F
M
E
G
L
F
K
G
V
G
E
V
M
F
Q
D
N
I
V
T
G
V
I
F
V
V
A
I
L
V
N
S
R
I
S
A
L
F
A
V
I
G
S
L
V
G
L
C
T
A
L
I
M
H
S
P
E
T
P
V
R
L
G
L
Y
G
F
N
S
V
L
C
G
I
A
M
G
G
I
F
F
Y
L
N
I
R
T
F
L
Y
A
L
G
C
M
V
L
G
A
I
A
T
G
A
F
S
V
L
L
S
P
I
G
M
P
A
L
T
W
P
F
I
V
V
T
W
L
F
L
F
A
G
S
M
F
R
N
I
A
Q
V
P
T
E
K
A
G
T
P
E
D
N
L
R
S
L
A
-
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.73
33%
-142
- C2 -
3M6E
-
UT_DESVH
A:
[11-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
P
L
I
E
F
C
D
S
V
C
R
G
C
G
Q
V
M
F
Q
N
N
T
V
T
G
L
L
F
F
A
--
G
I
F
Y
N
S
T
T
L
G
V
C
-
A
V
L
G
T
A
A
S
T
L
T
--------
A
Q
L
L
G
V
D
K
P
L
V
R
A
G
L
F
G
A
N
G
T
L
A
G
I
A
L
P
F
F
F
N
---
Y
E
P
A
M
L
G
Y
V
A
L
N
G
A
F
T
T
I
I
M
A
S
L
L
N
F
L
G
K
W
G
V
P
A
L
T
A
P
F
V
L
A
T
W
L
L
M
F
G
V
Y
K
L
S
L
F
H
P
G
A
L
I
A
P
A
--
L
P
S
V
A
D
M
G
T
V
T
G
R
T
F
M
E
G
L
F
K
G
V
G
E
V
M
F
Q
D
N
I
V
T
G
V
I
F
V
V
A
I
L
V
N
S
R
I
S
A
L
F
A
V
I
G
S
L
V
G
L
C
T
A
L
I
M
H
S
P
E
T
P
V
R
L
G
L
Y
G
F
N
S
V
L
C
G
I
A
M
G
G
I
F
F
Y
L
N
I
R
T
F
L
Y
A
L
G
C
M
V
L
G
A
I
A
T
G
A
F
S
V
L
L
S
P
I
G
M
P
A
L
T
W
P
F
I
V
V
T
W
L
F
L
F
A
G
S
M
F
R
N
I
A
Q
V
P
T
E
K
A
G
T
P
E
D
N
L
R
S
L
A
I
-------------------
7
PsiBlast_PDB
32.30
26%
52
- C1 -
4HOO
-
KDM4D_HUMAN
A:
[42-153]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
K
E
W
K
A
R
E
T
Y
D
N
I
S
E
I
L
I
A
T
P
L
Q
Q
V
A
S
G
R
A
G
V
F
T
Q
Y
H
K
--
K
A
A
A
---
M
T
V
G
E
Y
R
H
L
A
N
S
K
K
Y
Q
T
P
P
H
Q
N
F
E
D
L
E
R
K
Y
W
K
N
R
I
Y
N
S
P
I
Y
G
A
D
I
S
G
--
S
L
F
D
E
N
T
K
Q
W
N
L
-
G
H
L
G
T
I
Q
D
L
L
E
--------
K
E
C
G
V
V
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
L
G
E
P
K
T
W
Y
V
V
P
P
E
H
G
Q
R
L
E
R
L
A
R
E
L
F
P
G
S
C
G
A
F
L
R
H
K
V
A
L
I
S
P
T
V
L
K
E
N
G
I
P
F
N
R
I
T
Q
E
A
G
E
F
M
V
T
F
-
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
A
I
N
F
A
T
P
R
W
I
D
Y
G
K
M
A
S
Q
C
S
C
G
E
A
R
V
T
F
S
M
D
A
F
V
R
I
L
Q
P
E
R
Y
D
L
W
K
R
G
Q
D
-----------------------------------------------------------------------------------------------------------------------
27
Fugue
31.55
11%
158
- C2 -
2L9Q
-
HSP12_YEAST
A:
[1-109]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
D
A
G
R
K
G
F
G
E
--
K
A
S
E
A
L
K
P
D
S
Q
K
S
Y
A
E
Q
G
K
E
Y
I
T
D
K
A
D
K
V
A
G
K
V
Q
P
E
D
N
K
G
V
F
Q
G
V
H
--
D
S
A
E
K
G
K
D
N
A
E
G
Q
G
E
S
L
A
D
Q
A
R
D
Y
M
G
A
A
K
S
K
L
N
D
A
V
E
---
Y
V
S
G
R
V
H
G
E
E
D
P
T
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
29.43
26%
64
* C1 *
4HON
4
KDM4D_HUMAN
A:
[42-153]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
K
E
W
K
A
R
E
T
Y
D
N
I
S
E
I
L
I
A
T
P
L
Q
Q
V
A
S
G
R
A
G
V
F
T
Q
Y
H
K
K
K
K
A
M
T
-----
V
G
E
Y
R
H
L
A
N
S
K
K
Y
Q
T
P
P
H
Q
N
F
E
D
L
E
R
K
Y
W
K
N
R
I
Y
N
S
P
I
Y
G
A
D
I
S
G
--
S
L
F
D
E
N
T
K
Q
W
N
L
-
G
H
L
G
T
I
Q
D
L
L
E
--------
K
E
C
G
V
V
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
L
G
E
P
K
T
W
Y
V
V
P
P
E
H
G
Q
R
L
E
R
L
A
R
E
L
F
P
G
S
S
R
G
C
G
A
F
L
R
H
K
V
A
L
I
S
P
T
V
L
K
E
N
G
I
P
F
N
R
I
T
Q
E
A
G
E
F
M
-
V
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
A
I
N
F
A
T
P
R
W
I
D
Y
G
K
M
A
S
Q
C
S
C
G
E
A
R
V
T
F
S
M
D
A
F
V
R
I
L
Q
P
E
R
Y
D
L
W
K
R
G
Q
D
--------------------------------------------------------------------------------------------------------------------
23
Fugue
29.36
10%
128
- C2 -
2B9C
-
TPM1_RAT
A:
[98-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
D
R
A
Q
E
R
L
A
T
A
L
Q
K
L
E
E
A
E
K
A
A
D
E
S
E
R
G
M
K
V
I
E
S
R
A
Q
K
D
E
E
K
M
E
I
Q
E
I
Q
L
K
E
A
K
H
I
A
E
D
A
D
R
K
Y
E
E
V
A
R
K
L
V
I
I
E
S
D
L
E
R
A
E
E
R
A
E
L
S
E
G
K
C
A
E
L
E
E
E
L
K
T
V
T
N
N
L
K
S
L
E
D
K
V
E
E
L
L
S
K
N
Y
H
L
E
N
E
V
A
R
L
K
K
L
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
29.28
26%
65
- C1 -
3DXU
2
KDM4D_HUMAN
A:
[46-157]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
K
E
W
K
A
R
E
T
Y
D
N
I
S
E
I
L
I
A
T
P
L
Q
Q
V
A
S
G
R
A
G
V
F
T
Q
Y
H
K
K
K
K
A
M
T
-----
V
G
E
Y
R
H
L
A
N
S
K
K
Y
Q
T
P
P
H
Q
N
F
E
D
L
E
R
K
Y
W
K
N
R
I
Y
N
S
P
I
Y
G
A
D
I
S
G
--
S
L
F
D
E
N
T
K
Q
W
N
L
-
G
H
L
G
T
I
Q
D
L
L
E
--------
K
E
C
G
V
V
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
L
G
E
P
K
T
W
Y
V
V
P
P
E
H
G
Q
R
L
E
R
L
A
R
E
L
F
P
G
S
S
R
G
C
G
A
F
L
R
H
K
V
A
L
I
S
P
T
V
L
K
E
N
G
I
P
F
N
R
I
T
Q
E
A
G
E
F
M
-
V
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
A
I
N
F
A
T
P
R
W
I
D
Y
G
K
M
A
S
Q
C
S
C
G
E
A
R
V
T
F
S
M
D
A
F
V
R
I
L
Q
P
E
R
Y
D
L
W
K
R
G
Q
D
--------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
27.99
26%
64
- C1 -
3DXT
2
KDM4D_HUMAN
A:
[53-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
K
E
W
K
A
R
E
T
Y
D
N
I
S
E
I
L
I
A
T
P
L
Q
Q
V
A
S
G
R
A
G
V
F
T
Q
Y
H
K
K
K
K
A
M
T
-----
V
G
E
Y
R
H
L
A
N
S
K
K
Y
Q
T
P
P
H
Q
N
F
E
D
L
E
R
K
Y
W
K
N
R
I
Y
N
S
P
I
Y
G
A
D
I
S
G
--
S
L
F
D
E
N
T
K
Q
W
N
L
-
G
H
L
G
T
I
Q
D
L
L
E
--------
K
E
C
G
V
V
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
L
G
E
P
K
T
W
Y
V
V
P
P
E
H
G
Q
R
L
E
R
L
A
R
E
L
F
P
G
S
S
R
G
C
G
A
F
L
R
H
K
V
A
L
I
S
P
T
V
L
K
E
N
G
I
P
F
N
R
I
T
Q
E
A
G
E
F
M
-
V
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
A
I
N
F
A
T
P
R
W
I
D
Y
G
K
M
A
S
Q
C
S
C
G
E
A
R
V
T
F
S
M
D
A
F
V
R
I
L
Q
P
E
R
Y
D
L
W
K
R
G
Q
D
--------------------------------------------------------------------------------------------------------------------
18
HHSearch
27.47
25%
26
- C2 -
3HD6
1
RHCG_HUMAN
A:
[283-366]
------------------------------------------------------------------------------------------------------------------------------
D
M
V
H
I
Q
N
A
T
L
A
G
G
V
A
V
G
TA
A
E
M
M
L
M
P
Y
G
A
L
I
I
G
F
V
C
G
I
I
S
T
L
G
F
V
Y
L
T
P
F
L
E
S
R
L
H
I
Q
D
T
C
G
I
N
N
L
H
G
I
P
G
I
I
G
G
I
V
G
A
V
T
A
A
S
D
W
T
A
R
T
Q
G
K
F
Q
I
Y
G
L
L
V
T
L
A
M
A
L
M
G
G
I
I
V
G
L
I
L
R
L
P
F
W
G
Q
P
S
D
E
N
C
F
E
D
A
V
Y
W
E
M
P
E
G
N
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
26.72
25%
12
- C2 -
3HD6
1
RHCG_HUMAN
A:
[283-366]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
V
H
I
Q
N
A
T
L
A
G
G
V
A
V
G
TA
A
E
M
M
L
M
P
Y
G
A
L
I
I
G
F
V
C
G
I
I
S
T
L
G
F
V
Y
L
T
P
F
L
E
S
R
L
H
I
Q
D
T
C
G
I
N
N
L
H
G
I
P
G
I
I
G
G
I
V
G
A
V
T
A
A
S
D
W
T
A
R
T
Q
G
K
F
Q
I
Y
G
L
L
V
T
L
A
M
A
L
M
G
G
I
I
V
G
L
I
L
R
L
P
F
W
G
Q
P
S
D
E
N
C
F
E
D
A
V
Y
W
E
M
P
E
G
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
26.46
18%
187
- C2 -
2IC6
-
?
A:
[2-72]
-------------------------------------------
S
T
L
K
E
V
Q
D
N
I
T
L
H
E
Q
R
L
V
T
T
R
Q
K
L
K
D
A
E
R
A
V
E
L
D
--
P
D
D
V
N
K
S
T
L
Q
S
R
R
A
A
V
S
A
L
E
T
K
L
G
E
L
K
R
E
L
A
D
L
I
A
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
26.40
13%
147
- C2 -
2OTO
-
?
A:
[56-192]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
N
P
A
I
Q
N
I
R
L
R
H
E
N
K
D
L
K
A
R
L
E
N
A
M
E
V
A
G
R
D
F
K
R
A
E
E
L
E
K
A
K
Q
A
L
E
D
Q
R
K
D
L
E
T
K
L
K
E
L
Q
--
Q
D
Y
D
L
A
K
E
S
T
S
W
D
R
Q
R
L
E
K
E
L
E
E
K
K
E
A
L
E
L
A
I
D
-
Q
A
S
R
D
Y
H
R
A
T
A
L
E
K
E
L
E
E
K
K
K
A
L
E
L
A
I
D
Q
A
S
Q
D
Y
N
R
A
N
V
L
E
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
26.06
14%
268
* C2 *
2Q6Q
-
SPC42_YEAST
A:
[3-64]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
N
K
E
L
N
F
K
L
R
E
K
Q
N
E
I
F
E
L
K
K
I
A
E
T
L
R
S
K
L
E
K
Y
V
D
I
T
K
K
L
E
D
Q
N
L
N
L
Q
I
K
I
S
D
L
E
K
---
K
L
S
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
23.83
8%
216
- C2 -
4WY4
-
SNP29_HUMAN
C:
[1-78]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
R
Q
Q
Y
L
R
Q
E
V
L
R
R
A
E
A
T
A
A
S
T
S
R
S
L
A
L
M
Y
E
S
E
K
V
G
V
A
S
S
E
E
L
A
R
Q
R
G
V
L
E
R
T
E
K
M
V
D
---
K
M
D
Q
D
L
K
I
S
Q
K
H
I
N
S
I
K
S
V
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------