@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : VGLU1_HUMAN: (2015-12-12 )
MEFRQEEFRKLAGRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAEPPGAPPAPPPSYGATHSTFQPPRPPPPVRDY
Atome Classification :
(20 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110....-------...120.......--130.......140-......---..150-....---.....160...--..--.-.170.....-..180...----....190-........200...-....-210......-.220..------....--.230------------------------...-......240.......250.......260--.......270.......280.......290.-......300.......310.......320.......330-.---......340--........350.......360.......370.......380.......390......--.---400..-.-.-.-..410.......420..-......-430.......440...-.....-450.......460.....-..470.......480.......490.......500.......510........520....---...530.......540.......550.......560
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-ME
F
R
Q
E
E
F
R
K
L
A
G
R
A
L
G
K
L
H
R
L
L
E
K
R
QEGA
E
T
L
E
LSADGRPVTTQTRDP
P
V
V
D
C
T
CFGL
P
R
R
Y
I
I
A
I
M
S
G
L
G
F
C
I
S
FGIRCN
L
G
V
A
I
V
S
MVNNSTTHRG
G
H
V
V
V
Q
KAQFSWDP
E
T
V
-------
G
L
I
HG
S
F
F
W
G
Y
I
V
--
T
QIP
G
G
F
I
C
Q
K
F
--AANR
V
F
---
G
F
A
---
I
V
AT---
S
T
L
N
M
LIPSAA--R
V
--
H
-
Y
G
C
V
I
F
V
R
I
-
L
Q
G
L
VEGV----T
Y
P
A
C
H
--
G
I
W
S
KWAP
P
L
E
R
SR-
L
A
T
T
-
A
F
C
GSYA
G
A
-
V
V
A
M
P
L
------
A
G
V
L
--
V
Q--------------------------YSG-W
S
S
V
F
Y
V
Y
G
S
F
G
I
F
W
Y
L
F
W
L
L
V
SYESPAL--HPSI
S
E
E
E
R
K
Y
I
E
D
A
IG
E
S
A
K
L
M
N
P
L
T
KFS
T
-
P
W
R
R
F
F
TSM
P
V
Y
A
I
I
V
A
N
F
C
R
S
W
T
F
Y
L
L
L
ISQ
P
A
Y
F
E
E
V
-F---GF
E
I
S
K
V
G
---
L
V
S
A
L
P
H
L
V
M
T
I
I
VPIG
G
Q
I
A
D
F
L
R
SRRIM
S
T
T
N
V
R
K
L
M
NCGGFG
M
E
A
T
L
L
L
V
V
GYS--H---SK
G
V
A
-
I
-
S
-
F
-
L
V
L
A
VGFS
G
F
A
I
S-GF
N
-
V
N
H
LDI-
A
P
R
Y
A
S
I
L
M
G
IS-N
G
V
-
G
T
LSG-
M
V
C
P
I
I
V
G
A
M
TKHK
T
R
E
E
-
W
Q
Y
V
F
L
I
A
S
L
V
HYG
G
V
I
F
Y
G
V
FASGEKQPWA
E
P
E
E
M
S
E
E
KCGFV-GHDQLAGSDDSEMED---EAEPPGAPPAPPPSYGATHSTFQPPRPPPPVRDY--
18
Fugue
79.38
20%
-70
- C1 -
4IWS
-
?
A:
[23-515]
-
M
N
R
S
A
L
D
F
R
H
F
V
D
H
L
R
R
Q
-
G
D
L
V
D
V
H
T
E
V
D
A
N
L
E
I
G
A
I
T
R
R
V
Y
E
R
R
A
P
A
P
L
F
H
N
I
R
D
S
L
P
G
A
R
V
L
G
A
P
A
G
L
R
A
------
D
R
A
R
A
H
S
R
L
A
L
H
F
G
L
P
E
H
S
G
P
R
D
I
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A
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L
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A
A
M
R
A
E
P
I
APRRLER
G
P
V
Q
E
N
V
W
L
G
E
Q
V
DL
T
R
F
P
V
P
L
L
-
H
E
Q
--
D
G
G
R
Y
F
GTY
G
F
H
---
V
V
Q
T
---
P
D
G
S
W
D
S
W
S
V
G
--
R
----------
L
M
L
V
-
D
R
N
T
L
A
G
P
----
T
I
P
T
Q
H
I
G
I
I
R
E
Q
W
R
R
L
G
K
P
T
P
-
W
A
M
A
-
L
G
A
P
P
A
A
L
A
-
A
A
G
M
P
L
PEGVSE
A
G
Y
V
--
G
A
--------------------------
L
V
G
-
E
P
V
E
V
V
R
T
Q
T
N
G
L
-----
W
V
P
A
N
T
E
-
I
V
L
--
E
G
E
I
S
L
D
E
-
T
A
L
E
G
P
M
G
E
Y
H
G
Y
S
F
P
I
G
-----------
K
P
Q
P
L
F
H
V
H
A
L
S
F
R
D
Q
P
I
L
P
I
C
V
A
G
T
P
P
--
E
E
N
-
H
---
T
-----------------------------
I
W
G
T
M
I
S
A
Q
L
L
D
V
A
Q
N
A
G
L
---------
P
V
D
M
V
W
C
S
Y
E
--
A
---
A
T
C
-------
W
-
A
V
L
S
I
D
V
Q
R
L
A
A
L
-
G
---
T
D
A
A
A
F
-
A
A
R
V
A
E
T
V
F
G
--------
S
H
A
G
-
H
L
V
P
K
L
I
L
V
G
N
D
I
D
V
T
E
I
-
D
Q
V
V
W
A
L
A
T
R
A
H
------------
P
L
H
D
H
F
A
F
P
Q
I
R
D
F
P
M
V
P
Y
L
D
A
E
D
K
A
R
G
S
G
G
R
L
V
I
N
CLY
P
E
Q
F
A
G
Q
M
R
A
A
T
A
S
F
R
H
A
Y
P
T
A
L
R
R
R
V
E
E
R
W
S
D
Y
GF
13
Fugue
70.72
13%
-109
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
----------------------------------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
----------------
V
E
Q
G
F
S
R
G
D
L
-------
G
F
A
L
S
G
I
S
I
A
Y
G
F
--
S
K
F
I
M
G
S
V
S
D
R
S
--
N
P
R
V
F
L
---
P
A
G
---
L
I
L
A
---
A
A
V
M
L
F
M
G
F
V
P
--
W
A
T
S
S
-
I
A
V
M
F
V
L
L
F
-
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
--
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
-
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
------
F
L
L
G
--
M
A
--------------------------
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
--
C
G
L
P
P
I
E
E
Y
K
--------------
N
D
T
A
K
Q
I
-
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
----
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
--
N
---
P
T
V
D
M
-
I
-
C
-
M
-
I
V
I
G
F
L
I
Y
G
P
V
M
L
-
I
G
L
-
H
A
L
E
L
A
-
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
-
G
Y
L
G
G
-
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
-
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--------------------------------------------------------------
23
HHSearch
69.89
15%
-125
- C2 -
1PW4
-
GLPT_ECOLI
A:
[23-433]
----------------------------------------------------------
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
----------------
V
E
Q
G
F
S
R
G
D
L
-------
G
F
A
L
S
G
I
S
I
A
Y
G
F
--
S
K
F
I
M
G
S
V
S
D
R
S
--
N
P
R
V
F
L
---
P
A
G
---
L
I
L
A
---
A
A
V
M
L
F
M
G
F
V
P
W
A
T
S
--
S
-
I
A
V
M
F
V
L
L
F
-
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
--
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
-
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
------
F
L
L
G
--
M
A
W-------------------------
F
N
D
-
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
--
C
G
L
P
P
I
E
E
Y
K
N
D
---------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
------
G
-
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
PA
G
---
N
P
T
V
D
M
I
-
C
-
M
-
I
V
I
G
F
L
I
Y
G
P
V
M
L
-
I
G
L
-
H
A
L
E
L
A
-
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
-
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
---
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------------------------------------
24
HHSearch
58.26
14%
-124
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[34-422]
------------------------------------------------------------------------
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
---------------
Q
Q
A
F
T
L
T
N
F
Q
A
-------
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
--
I
P
I
P
A
G
I
L
M
K
K
L
--
S
Y
K
A
G
I
---
I
T
G
---
L
F
L
Y
---
A
L
G
A
A
L
F
W
P
A
A
E
-
I
M
--
N
-
Y
T
L
F
L
V
G
L
F
-
I
I
A
A
G
L
G
C
----
L
E
T
A
A
N
--
P
F
V
T
V
L
G
P
E
S
S
G
H
F
-
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
------
G
Q
S
L
--
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
--
K
F
P
A
L
--
Q
S
D
N
H
S
D
A
----------------
K
Q
G
S
F
S
A
-
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
---
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
----------
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
--
G
---
G
H
V
G
L
-
I
-
A
-
L
-
T
L
C
S
A
F
M
-
S
I
Q
Y
P
T
I
F
S
-
L
G
I
K
N
L
-
G
Q
D
T
-
K
Y
G
S
S
F
I
--
V
M
-
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
---
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
--------------------------------------------------------------------------
15
Fugue
54.79
9%
-103
- C2 -
1PV6
-
LACY_ECOLI
A:
[1-417]
-
M
Y
Y
L
K
N
------------------------------------------------------
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
H
I
S
-----------------
K
S
D
T
-------
G
I
I
F
A
A
I
S
L
F
S
L
L
--
F
Q
P
L
F
G
L
L
S
D
K
L
GL
R
K
Y
L
L
W
---
I
I
T
---
G
M
L
V
---
M
F
A
P
F
F
I
F
I
F
G
--
P
L
--
L
-
Q
Y
N
I
L
V
G
S
I
-
V
G
G
I
Y
L
G
F
----
C
F
N
A
G
A
--
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
-
R
A
R
M
F
G
C
V
G
-
W
A
L
G
A
S
------
I
V
G
I
--
M
F
--------------------------
T
I
N
-
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
--
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
---------
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
-
G
---
T
R
V
F
G
Y
V
T
---
T
M
G
E
L
L
N
A
S
I
M
------------
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
--
S
---
A
L
E
V
V
-
I
-
L
-
K
-
T
L
H
M
F
E
V
P
F
L
L
V
G
-
C
F
K
-
Y
I
T
S
Q
F
-
E
V
R
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
---
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------------------------------------
27
HHSearch
53.32
12%
-103
* C2 *
2CFQ
-
LACY_ECOLI
A:
[35-396]
----------------------------------------------------------------------------------------------------------
H
D
I
N
H
I
S
K
S
D
T
-------
G
I
I
F
A
A
I
S
L
F
S
L
L
--
F
Q
P
L
F
G
L
L
S
D
K
L
--
G
L
R
K
Y
L
---
L
W
I
I
T
G
M
L
V
M
---
F
A
P
F
F
I
F
I
F
G
----
P
--
L
L
Q
Y
N
I
L
V
G
S
I
-
V
G
G
I
Y
L
G
F
CFNA
G
A
P
A
V
E
--
A
F
I
E
K
V
S
R
--
R
S
N
F
-
E
F
G
R
-
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
------
V
G
I
M
--
F
T
---------------------------
I
N
-
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
--
A
T
V
-
A
N
A
V
G
A
-------------
N
H
S
A
F
S
L
K
-
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
----------
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
--
T
---
S
A
L
E
V
-
V
-
I
-
L
-
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
-
Y
I
T
S
Q
F
-
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
-
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
---
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------------------------------------
25
HHSearch
53.26
13%
-117
- C2 -
3WDO
-
?
A:
[38-382]
----------------------------------------------------------------------------------------------------------
M
A
L
Q
G
A
S
E
A
L
I
-------
G
I
A
I
G
I
Y
G
L
T
Q
A
V
--
F
Q
I
P
F
G
L
L
S
D
R
I
--
G
R
K
P
L
I
---
V
G
G
---
L
A
V
F
---
A
A
G
S
V
I
A
A
L
S
----
D
--
S
-
I
W
G
I
I
L
G
R
A
-
L
Q
G
S
G
A
------
I
A
A
A
V
M
--
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
-
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
------
G
P
I
I
--
T
H
--------------------------
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
--
V
L
N
R
E
--------------------
S
G
M
V
K
G
-
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
--
A
---
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
----------
C
V
G
L
I
V
V
A
-
E
I
V
L
W
N
A
Q
--
T
---
Q
F
W
Q
L
-
V
V
G
-
V
-
Q
L
F
F
V
A
F
N
L
M
E
A
L
-
L
P
S
-
L
I
S
K
E
S
-
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
-
Q
F
L
G
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
---
F
D
-
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
-
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
---
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
------
26
HHSearch
48.83
11%
-87
- C2 -
2GFP
-
EMRD_ECOLI
A:
[34-360]
---------------------------------------------------------------------------------------------------------
M
A
R
D
L
N
V
R
E
G
A
V
-------
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
--
S
Q
L
F
Y
G
P
I
S
D
R
V
--
G
R
R
P
V
I
---
L
V
G
---
M
S
I
F
---
M
L
A
T
L
V
A
V
T
T
----
S
--
S
-
L
T
V
L
I
A
A
S
A
-
M
Q
G
M
G
T
G
V
----
G
G
V
M
A
R
--
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
-
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
------
G
G
L
L
--
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
--
D
A
P
----------------------
R
T
R
L
L
T
-
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
---------
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
---
N
V
W
T
L
-
L
-
V
-
P
-
A
A
L
F
F
F
G
A
G
M
L
F
P
-
L
A
T
-
S
G
A
M
E
P
-
F
P
F
L
A
G
T
A
G
A
L
V
-
G
G
L
-
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
-
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
---------------------------------------------------------------------------------
2
PsiBlast_PDB
43.39
24%
-89
- C1 -
1PW4
-
GLPT_ECOLI
A:
[96-290]
---------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
G
L
I
L
A
----
A
A
V
M
L
F
M
--
G
F
V
---
P
W
A
T
---
S
S
I
------------------
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
--
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
-
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
-
P
L
------
L
F
L
L
G
M
A
W
--------------------------
F
N
D
-
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
CG
L
P
P
I
E
E
Y
K
N
D
----------------
T
A
K
Q
I
-
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
--
D
---
M
I
C
M
I
-
V
-
I
-
G
-
F
L
I
Y
G
P
V
M
L
I
G
L
H
-
A
L
E
-
L
A
P
K
K
A
-
A
G
T
A
A
G
F
T
G
L
F
G
-
Y
L
G
-
G
S
V
A
A
-
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
-
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------------------------------------------
28
HHSearch
42.46
11%
-114
- C2 -
3WDO
-
?
A:
[12-179]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
---
G
A
S
E
A
L
I
G
---
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
----------
G
L
A
V
F
A
A
G
S
V
I
A
A
L
S
--
D
---
S
I
W
G
I
-
I
-
L
-
G
R
A
L
Q
G
S
G
--
A
I
A
A
A
-
V
M
A
-
L
L
S
D
L
T
-
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
-
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
---
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
-
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
---
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
--
30
HHSearch
40.43
14%
-98
- C2 -
1PW4
-
GLPT_ECOLI
A:
[281-431]
----------------------------------------------------------------------------------------------------------
K
E
V
K
H
F
A
L
D
K
S
-------
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
--
G
T
L
L
C
G
W
M
S
D
K
V
--
F
R
G
N
R
G
---
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
--
A
G
--
N
-
P
T
V
D
M
I
C
M
I
-
V
I
G
F
L
I
Y
G
----
P
V
M
L
I
G
--
L
H
A
L
E
L
A
P
K
K
A
A
G
T
-
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
------
V
G
Y
T
--
V
D
--------------------------
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
--
H
E
Q
L
L
Q
E
L
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
37.89
15%
-102
- C2 -
2GFP
-
EMRD_ECOLI
A:
[23-174]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
--
L
---
N
V
R
E
G
A
V
Q
---
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
----------
G
M
S
I
F
M
L
A
T
L
V
A
V
T
T
--
S
---
S
L
T
V
L
-
I
-
A
A
S
-
A
M
Q
G
M
G
T
-
G
V
G
G
V
-
M
A
R
T
L
P
R
D
L
Y
-
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
-
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
---
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
-
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
---
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
--
32
HHSearch
37.60
13%
-115
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[36-177]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
--
F
---
T
L
T
N
F
Q
A
G
---
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
----------
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
--
A
E
I
M
N
Y
T
L
F
-
L
-
V
G
L
-
F
I
I
A
A
G
L
-
G
C
L
E
T
-
A
A
N
-
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
-
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
-
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
-
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
---
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
--
29
HHSearch
36.74
11%
-95
- C2 -
2CFQ
-
LACY_ECOLI
A:
[257-396]
----------------------------------------------------------------------------------------------------------------
G
T
R
V
F
-------
G
Y
V
T
T
M
G
E
L
L
N
A
S
--
I
M
F
F
A
P
L
I
I
N
R
I
--
G
G
K
N
A
L
---
L
L
A
---
G
T
I
M
---
S
V
R
I
I
G
S
S
F
A
----
T
--
S
-
A
L
E
V
V
I
L
K
T
-
L
H
M
F
E
V
P
F
----
L
L
V
G
C
F
--
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
-
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
------
A
G
N
M
--
Y
E
--------------------------
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
--
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
30.40
46%
394
- C4 -
3BIW
-
NLGN1_RAT
A:
[40-64]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
P
Y
A
A
P
P
T
---
G
E
H
R
F
Q
P
P
E
P
P
S
P
W
S
D
I
--
17
Fugue
30.35
15%
171
- C1 -
1HF9
-
ATIF1_BOVIN
A:
[1-41]
A
L
K
K
H
H
E
N
E
I
S
H
H
A
K
E
I
E
R
L
Q
K
E
I
E
R
H
K
Q
S
I
K
K
L
K
Q
S
E
D
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
30.27
15%
171
- C1 -
1HF9
-
B:
[1-41]
A
L
K
K
H
H
E
N
E
I
S
H
H
A
K
E
I
E
R
L
Q
K
E
I
E
R
H
K
Q
S
I
K
K
L
K
Q
S
E
D
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
30.12
22%
204
- C1 -
2BEQ
-
SPIKE_CVHSA
A:
[914-949]
---
S
Q
I
Q
E
S
L
T
T
T
S
T
A
L
G
K
L
Q
D
V
V
N
Q
N
A
Q
A
L
N
T
L
V
K
Q
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
30.06
46%
371
* C4 *
3B3Q
-
NLGN1_MOUSE
A:
[53-77]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
P
Y
A
A
P
P
T
---
G
E
H
R
F
Q
P
P
E
P
P
S
P
W
S
D
I
--
8
PsiBlast_PDB
29.23
46%
382
- C4 -
3BIX
1
NLGN1_RAT
A:
[40-64]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
P
Y
A
A
P
P
T
---
G
E
H
R
F
Q
P
P
E
P
P
S
P
W
S
D
I
--